SEPHS2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SEPHS2
Entrez Gene ID	22928
Full Name	selenophosphate synthetase 2
Synonyms	SPS2
General protein information	Preferred Names selenophosphate synthetase 2 Names selenide, water dikinase 2 selenium donor protein 2 selenophosphate synthase 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p11.2
Summary	This gene encodes an enzyme that catalyzes the production of monoselenophosphate (MSP) from selenide and ATP. MSP is the selenium donor required for synthesis of selenocysteine (Sec), which is co-translationally incorporated into selenoproteins at in-frame UGA codons that normally signal translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This protein is itself a selenoprotein containing a Sec residue at its active site, suggesting the existence of an autoregulatory mechanism. It is preferentially expressed in tissues implicated in the synthesis of selenoproteins and in sites of blood cell development. A pseudogene for this locus has been identified on chromosome 5. [provided by RefSeq, May 2017].
Disorder MIM:	606218

mRNA and Protein(s)

mRNA	Protein	Name
NM_012248.4	NP_036380.2	selenide, water dikinase 2
NM_012248.3	NP_036380.2	selenide, water dikinase 2

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Sephs2	NP_033292.2
Bos taurus (cattle)	SEPHS2	NP_001108204.1
Rattus norvegicus (Norway rat)	Sephs2	NP_001073358.2
Xenopus tropicalis (tropical clawed frog)	sephs2	NP_001072895.2
Homo sapiens (human)	SEPHS2	NP_036380.2
Pan troglodytes (chimpanzee)	SEPHS2	NP_001108203.1
	SEPHS2	NP_001152892.1
Canis lupus familiaris (dog)	SEPHS2	NP_001108208.1
Danio rerio (zebrafish)	sps2	NP_001004295.2

Gene Ontology
Bibliography

Related articles in PubMed

Analysis of Novel Interactions between Components of the Selenocysteine Biosynthesis Pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43.
Oudouhou F, Casu B, Dopgwa Puemi AS, Sygusch J, Baron C
Biochemistry56(17)2261-2270(2017 05)

Selenoprotein Gene Nomenclature.
Gladyshev VN, Arn?r ES, Berry MJ, Brigelius-Floh? R, Bruford EA, Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland PR, Diamond AM, Driscoll DM, Ferreiro A, Floh? L, Green FR, Guig? R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A, Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, K?hrle J, Krol A, Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV, Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP, Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U, Simonovi? M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD, Zhang Y
The Journal of biological chemistry291(46)24036-24040(2016 Nov)

Selenium alters miRNA profile in an intestinal cell line: evidence that miR-185 regulates expression of GPX2 and SEPSH2.
Maciel-Dominguez A, Swan D, Ford D, Hesketh J
Molecular nutrition & food research57(12)2195-205(2013 Dec)

New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea.
Xu XM, Carlson BA, Zhang Y, Mix H, Kryukov GV, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL
Biological trace element research119(3)234-41(2007 Dec)

Recoding elements located adjacent to a subset of eukaryal selenocysteine-specifying UGA codons.
Howard MT, Aggarwal G, Anderson CB, Khatri S, Flanigan KM, Atkins JF
The EMBO journal24(8)1596-607(2005 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data confirm interactions among components of the early steps of the selenocysteine biosynthesis pathway (SEPSECS, SECP43, SEPHS1, and SEPHS2); SECP43, which interacts with SEPSECS and SEPHS1, is a globular protein that forms oligomers in vivo.
Title: Analysis of Novel Interactions between Components of the Selenocysteine Biosynthesis Pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43.

miR-185 plays a role in up-regulation of GPX2 and SEPHS2 expression.In the case of SEPHS2 this may contribute to maintaining selenoprotein synthesis.
Title: Selenium alters miRNA profile in an intestinal cell line: evidence that miR-185 regulates expression of GPX2 and SEPSH2.

the Sps1-encoded enzyme depends on a selenium salvage system that recycles l-selenocysteine, whereas the Sps2 enzyme can function with a selenite assimilation system
Title: Selenophosphate synthetase genes from lung adenocarcinoma cells: Sps1 for recycling L-selenocysteine and Sps2 for selenite assimilation.

The following SEPHS2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SEPHS2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09981	NM_012248.4 Latest version!	Homo sapiens selenophosphate synthetase 2 (SEPHS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu09981	NM_012248.3	Homo sapiens selenophosphate synthetase 2 (SEPHS2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SEPHS2 ( NM_012248.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036380.2 Homo sapiens selenophosphate synthetase 2 (SEPHS2), mRNA.

Price & Availability↑

CloneID	OHu09981
Clone ID Related Accession (Same CDS sequence)	NM_012248.4 , NM_012248.3
Accession Version	NM_012248.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-25
Organism	Homo sapiens(human)
Product	selenide, water dikinase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA550938.1 and BC002381.2. On May 17, 2019 this sequence version replaced NM_012248.3. ##Evidence-Data-START## Transcript is intronless :: SRR3476690.655944.1, SRR3476690.970298.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000478753.5/ ENSP00000418669.3 protein contains selenocysteine :: PMID: 8986768 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAAG CCTCGGCGAC GGGCGCCTGC GGAGAGGCGA TGGCAGCGGC GGAAGGCTCC 
TCGGGCCCGG CGGGCTTGAC TCTGGGCCGG AGCTTCTCGA ACTACCGGCC CTTCGAGCCC 
CAGGCGTTGG GCCTCAGCCC GAGCTGGCGG CTGACGGGCT TCTCCGGCAT GAAGGGCTGA 
GGCTGCAAGG TCCCGCAGGA GGCGCTGCTC AAACTCCTGG CGGGACTGAC GCGGCCGGAC 
GTGCGGCCCC CGCTGGGCCG GGGCCTGGTG GGTGGCCAGG AAGAGGCGTC CCAGGAAGCC 
GGCCTGCCGG CAGGAGCGGG CCCCAGCCCC ACCTTTCCAG CCCTGGGCAT CGGGATGGAC 
TCCTGCGTCA TCCCCCTGAG GCACGGGGGC CTGTCACTGG TGCAGACCAC GGACTTCTTT 
TACCCCTTGG TAGAAGATCC CTACATGATG GGGCGCATAG CTTGTGCCAA CGTGCTGAGT 
GACCTCTACG CCATGGGGAT TACTGAGTGT GACAACATGT TGATGTTACT CAGCGTCAGC 
CAGAGTATGA GTGAGGAGGA ACGCGAAAAG GTAACGCCAC TCATGGTCAA AGGCTTTCGG 
GATGCGGCTG AGGAAGGAGG GACGGCAGTG ACCGGTGGGC AAACGGTGGT CAACCCTTGG 
ATTATAATCG GTGGAGTTGC CACTGTAGTA TGCCAACCAA ATGAGTTCAT AATGCCGGAC 
AGCGCCGTCG TTGGGGACGT GCTGGTGTTA ACCAAACCGT TAGGAACCCA GGTTGCTGTC 
AATGCCCACC AATGGCTGGA TAATCCTGAA AGATGGAATA AAGTAAAGAT GGTGGTCTCC 
AGAGAAGAGG TGGAGCTGGC CTATCAGGAA GCCATGTTCA ATATGGCTAC CCTCAACAGA 
ACTGCTGCAG GTTTAATGCA CACATTTAAT GCCCATGCGG CCACAGATAT CACAGGCTTT 
GGCATTCTAG GACACTCCCA GAACCTTGCA AAACAACAAA GAAATGAAGT GTCCTTTGTT 
ATTCATAATC TGCCAATAAT TGCCAAGATG GCTGCCGTCA GCAAGGCCAG TGGACGGTTT 
GGGCTTCTTC AAGGAACCTC AGCTGAAACC TCTGGGGGAT TACTGATTTG TCTGCCAAGA 
GAACAGGCGG CTCGCTTTTG TTCTGAAATC AAATCCTCCA AGTACGGAGA GGGTCACCAA 
GCGTGGATCG TTGGCATTGT GGAAAAGGGA AACCGAACGG CCCGGATCAT TGACAAGCCG 
CGAGTTATTG AAGTCCTGCC TCGTGGGGCC ACAGCTGCTG TTCTTGCTCC TGACAGTTCA 
AATGCCTCCT CTGAGCCTAG CTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036380.2
CDS	148..1494
Translation	MAEASATGACGEAMAAAEGSSGPAGLTLGRSFSNYRPFEPQALGLSPSWRLTGFSGMKG*GCKVPQEALLKLLAGLTRPDVRPPLGRGLVGGQEEASQEAGLPAGAGPSPTFPALGIGMDSCVIPLRHGGLSLVQTTDFFYPLVEDPYMMGRIACANVLSDLYAMGITECDNMLMLLSVSQSMSEEEREKVTPLMVKGFRDAAEEGGTAVTGGQTVVNPWIIIGGVATVVCQPNEFIMPDSAVVGDVLVLTKPLGTQVAVNAHQWLDNPERWNKVKMVVSREEVELAYQEAMFNMATLNRTAAGLMHTFNAHAATDITGFGILGHSQNLAKQQRNEVSFVIHNLPIIAKMAAVSKASGRFGLLQGTSAETSGGLLICLPREQAARFCSEIKSSKYGEGHQAWIVGIVEKGNRTARIIDKPRVIEVLPRGATAAVLAPDSSNASSEPSS

Target ORF information:

RefSeq Version	NM_012248.4
Organism	Homo sapiens(human)
Definition	Homo sapiens selenophosphate synthetase 2 (SEPHS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012248.4

ORF Insert Sequence:

ATGGCGGAAG CCTCGGCGAC GGGCGCCTGC GGAGAGGCGA TGGCAGCGGC GGAAGGCTCC 
TCGGGCCCGG CGGGCTTGAC TCTGGGCCGG AGCTTCTCGA ACTACCGGCC CTTCGAGCCC 
CAGGCGTTGG GCCTCAGCCC GAGCTGGCGG CTGACGGGCT TCTCCGGCAT GAAGGGCTGA 
GGCTGCAAGG TCCCGCAGGA GGCGCTGCTC AAACTCCTGG CGGGACTGAC GCGGCCGGAC 
GTGCGGCCCC CGCTGGGCCG GGGCCTGGTG GGTGGCCAGG AAGAGGCGTC CCAGGAAGCC 
GGCCTGCCGG CAGGAGCGGG CCCCAGCCCC ACCTTTCCAG CCCTGGGCAT CGGGATGGAC 
TCCTGCGTCA TCCCCCTGAG GCACGGGGGC CTGTCACTGG TGCAGACCAC GGACTTCTTT 
TACCCCTTGG TAGAAGATCC CTACATGATG GGGCGCATAG CTTGTGCCAA CGTGCTGAGT 
GACCTCTACG CCATGGGGAT TACTGAGTGT GACAACATGT TGATGTTACT CAGCGTCAGC 
CAGAGTATGA GTGAGGAGGA ACGCGAAAAG GTAACGCCAC TCATGGTCAA AGGCTTTCGG 
GATGCGGCTG AGGAAGGAGG GACGGCAGTG ACCGGTGGGC AAACGGTGGT CAACCCTTGG 
ATTATAATCG GTGGAGTTGC CACTGTAGTA TGCCAACCAA ATGAGTTCAT AATGCCGGAC 
AGCGCCGTCG TTGGGGACGT GCTGGTGTTA ACCAAACCGT TAGGAACCCA GGTTGCTGTC 
AATGCCCACC AATGGCTGGA TAATCCTGAA AGATGGAATA AAGTAAAGAT GGTGGTCTCC 
AGAGAAGAGG TGGAGCTGGC CTATCAGGAA GCCATGTTCA ATATGGCTAC CCTCAACAGA 
ACTGCTGCAG GTTTAATGCA CACATTTAAT GCCCATGCGG CCACAGATAT CACAGGCTTT 
GGCATTCTAG GACACTCCCA GAACCTTGCA AAACAACAAA GAAATGAAGT GTCCTTTGTT 
ATTCATAATC TGCCAATAAT TGCCAAGATG GCTGCCGTCA GCAAGGCCAG TGGACGGTTT 
GGGCTTCTTC AAGGAACCTC AGCTGAAACC TCTGGGGGAT TACTGATTTG TCTGCCAAGA 
GAACAGGCGG CTCGCTTTTG TTCTGAAATC AAATCCTCCA AGTACGGAGA GGGTCACCAA 
GCGTGGATCG TTGGCATTGT GGAAAAGGGA AACCGAACGG CCCGGATCAT TGACAAGCCG 
CGAGTTATTG AAGTCCTGCC TCGTGGGGCC ACAGCTGCTG TTCTTGCTCC TGACAGTTCA 
AATGCCTCCT CTGAGCCTAG CTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SEPHS2 ( NM_012248.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036380.2 Homo sapiens selenophosphate synthetase 2 (SEPHS2), mRNA.

Price & Availability↑

CloneID	OHu09981
Clone ID Related Accession (Same CDS sequence)	NM_012248.4 , NM_012248.3
Accession Version	NM_012248.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1347bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	selenide, water dikinase 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA550938.1, BC002381.2 and BG565156.1. On Aug 18, 2013 this sequence version replaced NM_012248.2. ##RefSeq-Attributes-START## protein contains selenocysteine :: PMID: 8986768 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGGAAG CCTCGGCGAC GGGCGCCTGC GGAGAGGCGA TGGCAGCGGC GGAAGGCTCC 
TCGGGCCCGG CGGGCTTGAC TCTGGGCCGG AGCTTCTCGA ACTACCGGCC CTTCGAGCCC 
CAGGCGTTGG GCCTCAGCCC GAGCTGGCGG CTGACGGGCT TCTCCGGCAT GAAGGGCTGA 
GGCTGCAAGG TCCCGCAGGA GGCGCTGCTC AAACTCCTGG CGGGACTGAC GCGGCCGGAC 
GTGCGGCCCC CGCTGGGCCG GGGCCTGGTG GGTGGCCAGG AAGAGGCGTC CCAGGAAGCC 
GGCCTGCCGG CAGGAGCGGG CCCCAGCCCC ACCTTTCCAG CCCTGGGCAT CGGGATGGAC 
TCCTGCGTCA TCCCCCTGAG GCACGGGGGC CTGTCACTGG TGCAGACCAC GGACTTCTTT 
TACCCCTTGG TAGAAGATCC CTACATGATG GGGCGCATAG CTTGTGCCAA CGTGCTGAGT 
GACCTCTACG CCATGGGGAT TACTGAGTGT GACAACATGT TGATGTTACT CAGCGTCAGC 
CAGAGTATGA GTGAGGAGGA ACGCGAAAAG GTAACGCCAC TCATGGTCAA AGGCTTTCGG 
GATGCGGCTG AGGAAGGAGG GACGGCAGTG ACCGGTGGGC AAACGGTGGT CAACCCTTGG 
ATTATAATCG GTGGAGTTGC CACTGTAGTA TGCCAACCAA ATGAGTTCAT AATGCCGGAC 
AGCGCCGTCG TTGGGGACGT GCTGGTGTTA ACCAAACCGT TAGGAACCCA GGTTGCTGTC 
AATGCCCACC AATGGCTGGA TAATCCTGAA AGATGGAATA AAGTAAAGAT GGTGGTCTCC 
AGAGAAGAGG TGGAGCTGGC CTATCAGGAA GCCATGTTCA ATATGGCTAC CCTCAACAGA 
ACTGCTGCAG GTTTAATGCA CACATTTAAT GCCCATGCGG CCACAGATAT CACAGGCTTT 
GGCATTCTAG GACACTCCCA GAACCTTGCA AAACAACAAA GAAATGAAGT GTCCTTTGTT 
ATTCATAATC TGCCAATAAT TGCCAAGATG GCTGCCGTCA GCAAGGCCAG TGGACGGTTT 
GGGCTTCTTC AAGGAACCTC AGCTGAAACC TCTGGGGGAT TACTGATTTG TCTGCCAAGA 
GAACAGGCGG CTCGCTTTTG TTCTGAAATC AAATCCTCCA AGTACGGAGA GGGTCACCAA 
GCGTGGATCG TTGGCATTGT GGAAAAGGGA AACCGAACGG CCCGGATCAT TGACAAGCCG 
CGAGTTATTG AAGTCCTGCC TCGTGGGGCC ACAGCTGCTG TTCTTGCTCC TGACAGTTCA 
AATGCCTCCT CTGAGCCTAG CTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036380.2
CDS	249..1595
Translation	MAEASATGACGEAMAAAEGSSGPAGLTLGRSFSNYRPFEPQALGLSPSWRLTGFSGMKG*GCKVPQEALLKLLAGLTRPDVRPPLGRGLVGGQEEASQEAGLPAGAGPSPTFPALGIGMDSCVIPLRHGGLSLVQTTDFFYPLVEDPYMMGRIACANVLSDLYAMGITECDNMLMLLSVSQSMSEEEREKVTPLMVKGFRDAAEEGGTAVTGGQTVVNPWIIIGGVATVVCQPNEFIMPDSAVVGDVLVLTKPLGTQVAVNAHQWLDNPERWNKVKMVVSREEVELAYQEAMFNMATLNRTAAGLMHTFNAHAATDITGFGILGHSQNLAKQQRNEVSFVIHNLPIIAKMAAVSKASGRFGLLQGTSAETSGGLLICLPREQAARFCSEIKSSKYGEGHQAWIVGIVEKGNRTARIIDKPRVIEVLPRGATAAVLAPDSSNASSEPSS

Target ORF information:

RefSeq Version	NM_012248.3
Organism	Homo sapiens(human)
Definition	Homo sapiens selenophosphate synthetase 2 (SEPHS2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012248.3

ORF Insert Sequence:

ATGGCGGAAG CCTCGGCGAC GGGCGCCTGC GGAGAGGCGA TGGCAGCGGC GGAAGGCTCC 
TCGGGCCCGG CGGGCTTGAC TCTGGGCCGG AGCTTCTCGA ACTACCGGCC CTTCGAGCCC 
CAGGCGTTGG GCCTCAGCCC GAGCTGGCGG CTGACGGGCT TCTCCGGCAT GAAGGGCTGA 
GGCTGCAAGG TCCCGCAGGA GGCGCTGCTC AAACTCCTGG CGGGACTGAC GCGGCCGGAC 
GTGCGGCCCC CGCTGGGCCG GGGCCTGGTG GGTGGCCAGG AAGAGGCGTC CCAGGAAGCC 
GGCCTGCCGG CAGGAGCGGG CCCCAGCCCC ACCTTTCCAG CCCTGGGCAT CGGGATGGAC 
TCCTGCGTCA TCCCCCTGAG GCACGGGGGC CTGTCACTGG TGCAGACCAC GGACTTCTTT 
TACCCCTTGG TAGAAGATCC CTACATGATG GGGCGCATAG CTTGTGCCAA CGTGCTGAGT 
GACCTCTACG CCATGGGGAT TACTGAGTGT GACAACATGT TGATGTTACT CAGCGTCAGC 
CAGAGTATGA GTGAGGAGGA ACGCGAAAAG GTAACGCCAC TCATGGTCAA AGGCTTTCGG 
GATGCGGCTG AGGAAGGAGG GACGGCAGTG ACCGGTGGGC AAACGGTGGT CAACCCTTGG 
ATTATAATCG GTGGAGTTGC CACTGTAGTA TGCCAACCAA ATGAGTTCAT AATGCCGGAC 
AGCGCCGTCG TTGGGGACGT GCTGGTGTTA ACCAAACCGT TAGGAACCCA GGTTGCTGTC 
AATGCCCACC AATGGCTGGA TAATCCTGAA AGATGGAATA AAGTAAAGAT GGTGGTCTCC 
AGAGAAGAGG TGGAGCTGGC CTATCAGGAA GCCATGTTCA ATATGGCTAC CCTCAACAGA 
ACTGCTGCAG GTTTAATGCA CACATTTAAT GCCCATGCGG CCACAGATAT CACAGGCTTT 
GGCATTCTAG GACACTCCCA GAACCTTGCA AAACAACAAA GAAATGAAGT GTCCTTTGTT 
ATTCATAATC TGCCAATAAT TGCCAAGATG GCTGCCGTCA GCAAGGCCAG TGGACGGTTT 
GGGCTTCTTC AAGGAACCTC AGCTGAAACC TCTGGGGGAT TACTGATTTG TCTGCCAAGA 
GAACAGGCGG CTCGCTTTTG TTCTGAAATC AAATCCTCCA AGTACGGAGA GGGTCACCAA 
GCGTGGATCG TTGGCATTGT GGAAAAGGGA AACCGAACGG CCCGGATCAT TGACAAGCCG 
CGAGTTATTG AAGTCCTGCC TCGTGGGGCC ACAGCTGCTG TTCTTGCTCC TGACAGTTCA 
AATGCCTCCT CTGAGCCTAG CTCGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Analysis of Novel Interactions between Components of the Selenocysteine Biosynthesis Pathway, SEPHS1, SEPHS2, SEPSECS, and SECp43.
Biochemistry56(17)2261-2270(2017 05)
Oudouhou F,Casu B,Dopgwa Puemi AS,Sygusch J,Baron C

Selenoprotein Gene Nomenclature.
The Journal of biological chemistry291(46)24036-24040(2016 Nov)
Gladyshev VN,Arn?r ES,Berry MJ,Brigelius-Floh? R,Bruford EA,Burk RF,Carlson BA,Castellano S,Chavatte L,Conrad M,Copeland PR,Diamond AM,Driscoll DM,Ferreiro A,Floh? L,Green FR,Guig? R,Handy DE,Hatfield DL,Hesketh J,Hoffmann PR,Holmgren A,Hondal RJ,Howard MT,Huang K,Kim HY,Kim IY,K?hrle J,Krol A,Kryukov GV,Lee BJ,Lee BC,Lei XG,Liu Q,Lescure A,Lobanov AV,Loscalzo J,Maiorino M,Mariotti M,Sandeep Prabhu K,Rayman MP,Rozovsky S,Salinas G,Schmidt EE,Schomburg L,Schweizer U,Simonovi? M,Sunde RA,Tsuji PA,Tweedie S,Ursini F,Whanger PD,Zhang Y

Selenium alters miRNA profile in an intestinal cell line: evidence that miR-185 regulates expression of GPX2 and SEPSH2.
Molecular nutrition & food research57(12)2195-205(2013 Dec)
Maciel-Dominguez A,Swan D,Ford D,Hesketh J

New developments in selenium biochemistry: selenocysteine biosynthesis in eukaryotes and archaea.
Biological trace element research119(3)234-41(2007 Dec)
Xu XM,Carlson BA,Zhang Y,Mix H,Kryukov GV,Glass RS,Berry MJ,Gladyshev VN,Hatfield DL

Recoding elements located adjacent to a subset of eukaryal selenocysteine-specifying UGA codons.
The EMBO journal24(8)1596-607(2005 Apr)
Howard MT,Aggarwal G,Anderson CB,Khatri S,Flanigan KM,Atkins JF

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SEPHS2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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