MSRB2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	MSRB2
Entrez Gene ID	22921
Full Name	methionine sulfoxide reductase B2
Synonyms	CBS-1,CBS1,CGI-131,MSRB,PILB
General protein information	Preferred Names methionine sulfoxide reductase B2 Names methionine-R-sulfoxide reductase B2, mitochondrial pilin-like transcription factor
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p12.2
Disorder MIM:	613782

mRNA and Protein(s)

mRNA	Protein	Name
NM_012228.3	NP_036360.3	methionine-R-sulfoxide reductase B2, mitochondrial precursor
XM_011519426.2	XP_011517728.1	methionine-R-sulfoxide reductase B2, mitochondrial isoform X1
NM_012228.4	NP_036360.3	methionine-R-sulfoxide reductase B2, mitochondrial precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Msrb2	NP_083895.1
Homo sapiens (human)	MSRB2	NP_036360.3
Bos taurus (cattle)	MSRB2	NP_001193059.1
Rattus norvegicus (Norway rat)	Msrb2	NP_001026830.1
Danio rerio (zebrafish)	msrb2	NP_998086.1
Xenopus tropicalis (tropical clawed frog)	msrb2	NP_001015905.1
Pan troglodytes (chimpanzee)	MSRB2	XP_001155268.2
	LOC711305	XP_001100084.2
Canis lupus familiaris (dog)	MSRB2	XP_850458.2
Caenorhabditis elegans (roundworm)	F44E2.6	NP_001254966.1

Gene Ontology
Bibliography

Related articles in PubMed

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Floyd BJ, Wilkerson EM, Veling MT, Minogue CE, Xia C, Beebe ET, Wrobel RL, Cho H, Kremer LS, Alston CL, Gromek KA, Dolan BK, Ulbrich A, Stefely JA, Bohl SL, Werner KM, Jochem A, Westphall MS, Rensvold JW, Taylor RW, Prokisch H, Kim JP, Coon JJ, Pagliarini DJ
Molecular cell63(4)621-632(2016 Aug)

Identification of activators of methionine sulfoxide reductases A and B.
Cudic P, Joshi N, Sagher D, Williams BT, Stawikowski MJ, Weissbach H
Biochemical and biophysical research communications469(4)863-7(2016 Jan)

Identification of the mitochondrial MSRB2 as a binding partner of LG72.
Otte DM, Rask? T, Wang M, Dreiseidler M, Drews E, Schrage H, Wojtalla A, H?hfeld J, Wanker E, Zimmer A
Cellular and molecular neurobiology34(8)1123-30(2014 Nov)

Proteome alteration in oxidative stress-sensitive methionine sulfoxide reductase-silenced HEK293 cells.
Ugarte N, Ladouce R, Radjei S, Gareil M, Friguet B, Petropoulos I
Free radical biology & medicine651023-36(2013 Dec)

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
Comuzzie AG, Cole SA, Laston SL, Voruganti VS, Haack K, Gibbs RA, Butte NF
PloS one7(12)e51954(2012)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

this study we have identified, for the first time, compounds structurally related to the natural products fusaricidins that markedly activate recombinant bovine and human MsrA and human MsrB.
Title: Identification of activators of methionine sulfoxide reductases A and B.

the mitochondrial methionine-R-sulfoxide reductase B2 (MSRB2) is a specific interaction partner of LG72.
Title: Identification of the mitochondrial MSRB2 as a binding partner of LG72.

Silencing the expression of the main Msr elements-MsrA, MsrB1, or MsrB2 exacerbates sensitivity toward oxidative stress.
Title: Proteome alteration in oxidative stress-sensitive methionine sulfoxide reductase-silenced HEK293 cells.

Data show that glutaredoxin acts as a reductant for methionine sulfoxide reductases A and B (MsrA and MsrB) with or without resolving cysteine.
Title: Glutaredoxin serves as a reductant for methionine sulfoxide reductases with or without resolving cysteine.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following MSRB2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the MSRB2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06117	NM_012228.4 Latest version!	Homo sapiens methionine sulfoxide reductase B2 (MSRB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
OHu65138	XM_011519426.2 Latest version!	Homo sapiens methionine sulfoxide reductase B2 (MSRB2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu06117	NM_012228.3	Homo sapiens methionine sulfoxide reductase B2 (MSRB2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$134.50-$188.30 $269.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

MSRB2 ( NM_012228.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_036360.3 Homo sapiens methionine sulfoxide reductase B2 (MSRB2), mRNA.

Price & Availability↑

CloneID	OHu06117
Clone ID Related Accession (Same CDS sequence)	NM_012228.3 , NM_012228.4
Accession Version	NM_012228.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-09
Organism	Homo sapiens(human)
Product	methionine-R-sulfoxide reductase B2, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC117471.1, AF151889.1 and AL139281.7. On Nov 8, 2006 this sequence version replaced NM_012228.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.49668.1, SRR1803611.63668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGCGCGGC TCCTCTGGTT GCTCCGGGGC CTGACCCTCG GAACTGCGCC TCGGCGGGCG 
GTGCGGGGCC AAGCGGGCGG CGGCGGGCCC GGCACCGGGC CGGGACTGGG GGAGGCAGGG 
TCTCTTGCAA CGTGTGAGCT GCCTCTTGCC AAGAGTGAGT GGCAAAAGAA ACTAACCCCG 
GAGCAGTTCT ACGTCACAAG AGAAAAGGGA ACGGAACCGC CTTTCAGTGG GATCTACCTG 
AATAACAAGG AAGCAGGAAT GTATCATTGC GTGTGCTGCG ACAGTCCACT CTTCAGTTCT 
GAGAAAAAGT ACTGCTCTGG CACTGGGTGG CCTTCGTTTT CCGAGGCTCA TGGTACGTCT 
GGCTCTGATG AAAGCCACAC AGGGATCCTG AGACGTCTGG ATACCTCGTT AGGATCAGCT 
CGCACAGAGG TTGTCTGCAA GCAGTGTGAA GCTCATCTAG GTCACGTGTT TCCTGATGGA 
CCTGGGCCCA ATGGTCAGAG GTTTTGCATC AACAGTGTGG CTTTGAAGTT CAAACCAAGG 
AAACACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036360.3
CDS	112..660
Translation	MARLLWLLRGLTLGTAPRRAVRGQAGGGGPGTGPGLGEAGSLATCELPLAKSEWQKKLTPEQFYVTREKGTEPPFSGIYLNNKEAGMYHCVCCDSPLFSSEKKYCSGTGWPSFSEAHGTSGSDESHTGILRRLDTSLGSARTEVVCKQCEAHLGHVFPDGPGPNGQRFCINSVALKFKPRKH

Target ORF information:

RefSeq Version	NM_012228.3
Organism	Homo sapiens(human)
Definition	Homo sapiens methionine sulfoxide reductase B2 (MSRB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012228.3

ORF Insert Sequence:

ATGGCGCGGC TCCTCTGGTT GCTCCGGGGC CTGACCCTCG GAACTGCGCC TCGGCGGGCG 
GTGCGGGGCC AAGCGGGCGG CGGCGGGCCC GGCACCGGGC CGGGACTGGG GGAGGCAGGG 
TCTCTTGCAA CGTGTGAGCT GCCTCTTGCC AAGAGTGAGT GGCAAAAGAA ACTAACCCCG 
GAGCAGTTCT ACGTCACAAG AGAAAAGGGA ACGGAACCGC CTTTCAGTGG GATCTACCTG 
AATAACAAGG AAGCAGGAAT GTATCATTGC GTGTGCTGCG ACAGTCCACT CTTCAGTTCT 
GAGAAAAAGT ACTGCTCTGG CACTGGGTGG CCTTCGTTTT CCGAGGCTCA TGGTACGTCT 
GGCTCTGATG AAAGCCACAC AGGGATCCTG AGACGTCTGG ATACCTCGTT AGGATCAGCT 
CGCACAGAGG TTGTCTGCAA GCAGTGTGAA GCTCATCTAG GTCACGTGTT TCCTGATGGA 
CCTGGGCCCA ATGGTCAGAG GTTTTGCATC AACAGTGTGG CTTTGAAGTT CAAACCAAGG 
AAACACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MSRB2 ( NM_012228.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036360.3 Homo sapiens methionine sulfoxide reductase B2 (MSRB2), mRNA.

Price & Availability↑

CloneID	OHu06117
Clone ID Related Accession (Same CDS sequence)	NM_012228.3 , NM_012228.4
Accession Version	NM_012228.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 549bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-09
Organism	Homo sapiens(human)
Product	methionine-R-sulfoxide reductase B2, mitochondrial precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC117471.1, AF151889.1 and AL139281.7. On Nov 22, 2018 this sequence version replaced NM_012228.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BI669177.1, SRR1660805.49668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000376510.8/ ENSP00000365693.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCGGC TCCTCTGGTT GCTCCGGGGC CTGACCCTCG GAACTGCGCC TCGGCGGGCG 
GTGCGGGGCC AAGCGGGCGG CGGCGGGCCC GGCACCGGGC CGGGACTGGG GGAGGCAGGG 
TCTCTTGCAA CGTGTGAGCT GCCTCTTGCC AAGAGTGAGT GGCAAAAGAA ACTAACCCCG 
GAGCAGTTCT ACGTCACAAG AGAAAAGGGA ACGGAACCGC CTTTCAGTGG GATCTACCTG 
AATAACAAGG AAGCAGGAAT GTATCATTGC GTGTGCTGCG ACAGTCCACT CTTCAGTTCT 
GAGAAAAAGT ACTGCTCTGG CACTGGGTGG CCTTCGTTTT CCGAGGCTCA TGGTACGTCT 
GGCTCTGATG AAAGCCACAC AGGGATCCTG AGACGTCTGG ATACCTCGTT AGGATCAGCT 
CGCACAGAGG TTGTCTGCAA GCAGTGTGAA GCTCATCTAG GTCACGTGTT TCCTGATGGA 
CCTGGGCCCA ATGGTCAGAG GTTTTGCATC AACAGTGTGG CTTTGAAGTT CAAACCAAGG 
AAACACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036360.3
CDS	31..579
Translation	MARLLWLLRGLTLGTAPRRAVRGQAGGGGPGTGPGLGEAGSLATCELPLAKSEWQKKLTPEQFYVTREKGTEPPFSGIYLNNKEAGMYHCVCCDSPLFSSEKKYCSGTGWPSFSEAHGTSGSDESHTGILRRLDTSLGSARTEVVCKQCEAHLGHVFPDGPGPNGQRFCINSVALKFKPRKH

Target ORF information:

RefSeq Version	NM_012228.4
Organism	Homo sapiens(human)
Definition	Homo sapiens methionine sulfoxide reductase B2 (MSRB2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012228.4

ORF Insert Sequence:

ATGGCGCGGC TCCTCTGGTT GCTCCGGGGC CTGACCCTCG GAACTGCGCC TCGGCGGGCG 
GTGCGGGGCC AAGCGGGCGG CGGCGGGCCC GGCACCGGGC CGGGACTGGG GGAGGCAGGG 
TCTCTTGCAA CGTGTGAGCT GCCTCTTGCC AAGAGTGAGT GGCAAAAGAA ACTAACCCCG 
GAGCAGTTCT ACGTCACAAG AGAAAAGGGA ACGGAACCGC CTTTCAGTGG GATCTACCTG 
AATAACAAGG AAGCAGGAAT GTATCATTGC GTGTGCTGCG ACAGTCCACT CTTCAGTTCT 
GAGAAAAAGT ACTGCTCTGG CACTGGGTGG CCTTCGTTTT CCGAGGCTCA TGGTACGTCT 
GGCTCTGATG AAAGCCACAC AGGGATCCTG AGACGTCTGG ATACCTCGTT AGGATCAGCT 
CGCACAGAGG TTGTCTGCAA GCAGTGTGAA GCTCATCTAG GTCACGTGTT TCCTGATGGA 
CCTGGGCCCA ATGGTCAGAG GTTTTGCATC AACAGTGTGG CTTTGAAGTT CAAACCAAGG 
AAACACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

MSRB2 ( XM_011519426.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011517728.1 Homo sapiens methionine sulfoxide reductase B2 (MSRB2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu65138
Clone ID Related Accession (Same CDS sequence)	XM_011519426.2
Accession Version	XM_011519426.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 426bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	methionine-R-sulfoxide reductase B2, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011519426.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGCGGC TCCTCTGGTT GCTCCGGGGC CTGACCCTCG GAACTGCGCC TCGGCGGGCG 
GTGCGGGGCC AAGCGGGCGG CGGCGGGCCC GGCACCGGGC CGGGACTGGG GGAGGCAGGG 
TCTCTTGCAA CGTGTGAGCT GCCTCTTGCC AAGAGTGAGT GGCAAAAGAA ACTAACCCCG 
GAGCAGTTCT ACGTCACAAG AGAAAAGGGA ACGGAACCGC CTTTCAGTGG GATCTACCTG 
AATAACAAGG AAGCAGGAAT GTATCATTGC GTGTGCTGCG ACAGTCCACT CTTCAGATCC 
TTGTTGGATA TCCAGAAAGA AGTCTTTAGC ATCAAAGGAT CAAGAAGTCC TTCCACTTCG 
AGAGGCAATG GCTTCGATAG TGAAGGTGCA GTGAGGACGA TTCCGGGGGG ACTGACTGTC 
GAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011517728.1
CDS	46..471
Translation	MARLLWLLRGLTLGTAPRRAVRGQAGGGGPGTGPGLGEAGSLATCELPLAKSEWQKKLTPEQFYVTREKGTEPPFSGIYLNNKEAGMYHCVCCDSPLFRSLLDIQKEVFSIKGSRSPSTSRGNGFDSEGAVRTIPGGLTVE

Target ORF information:

RefSeq Version	XM_011519426.2
Organism	Homo sapiens(human)
Definition	Homo sapiens methionine sulfoxide reductase B2 (MSRB2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011519426.2

ORF Insert Sequence:

ATGGCGCGGC TCCTCTGGTT GCTCCGGGGC CTGACCCTCG GAACTGCGCC TCGGCGGGCG 
GTGCGGGGCC AAGCGGGCGG CGGCGGGCCC GGCACCGGGC CGGGACTGGG GGAGGCAGGG 
TCTCTTGCAA CGTGTGAGCT GCCTCTTGCC AAGAGTGAGT GGCAAAAGAA ACTAACCCCG 
GAGCAGTTCT ACGTCACAAG AGAAAAGGGA ACGGAACCGC CTTTCAGTGG GATCTACCTG 
AATAACAAGG AAGCAGGAAT GTATCATTGC GTGTGCTGCG ACAGTCCACT CTTCAGATCC 
TTGTTGGATA TCCAGAAAGA AGTCTTTAGC ATCAAAGGAT CAAGAAGTCC TTCCACTTCG 
AGAGGCAATG GCTTCGATAG TGAAGGTGCA GTGAGGACGA TTCCGGGGGG ACTGACTGTC 
GAATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.
Molecular cell63(4)621-632(2016 Aug)
Floyd BJ,Wilkerson EM,Veling MT,Minogue CE,Xia C,Beebe ET,Wrobel RL,Cho H,Kremer LS,Alston CL,Gromek KA,Dolan BK,Ulbrich A,Stefely JA,Bohl SL,Werner KM,Jochem A,Westphall MS,Rensvold JW,Taylor RW,Prokisch H,Kim JP,Coon JJ,Pagliarini DJ

Identification of activators of methionine sulfoxide reductases A and B.
Biochemical and biophysical research communications469(4)863-7(2016 Jan)
Cudic P,Joshi N,Sagher D,Williams BT,Stawikowski MJ,Weissbach H

Identification of the mitochondrial MSRB2 as a binding partner of LG72.
Cellular and molecular neurobiology34(8)1123-30(2014 Nov)
Otte DM,Rask? T,Wang M,Dreiseidler M,Drews E,Schrage H,Wojtalla A,H?hfeld J,Wanker E,Zimmer A

Proteome alteration in oxidative stress-sensitive methionine sulfoxide reductase-silenced HEK293 cells.
Free radical biology & medicine651023-36(2013 Dec)
Ugarte N,Ladouce R,Radjei S,Gareil M,Friguet B,Petropoulos I

Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
PloS one7(12)e51954(2012)
Comuzzie AG,Cole SA,Laston SL,Voruganti VS,Haack K,Gibbs RA,Butte NF

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

MSRB2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報