KHDC4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KHDC4
Entrez Gene ID	22889
Full Name	KH domain containing 4, pre-mRNA splicing factor
Synonyms	BLOM7,KIAA0907,SNORA80EHG
General protein information	Preferred Names KH domain containing 4, pre-mRNA splicing factor Names protein BLOM7 brings lots of money 7
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q22

mRNA and Protein(s)

mRNA	Protein	Name
NM_014949.3	NP_055764.2	protein BLOM7
NM_014949.4	NP_055764.2	KH homology domain-containing protein 4

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KIAA0907	XP_851894.1
Gallus gallus (chicken)	KIAA0907	NP_001026499.1
Danio rerio (zebrafish)	kiaa0907	NP_997758.1
Xenopus tropicalis (tropical clawed frog)	kiaa0907	NP_001072751.1
	LOC718005	XP_001116296.1
Mus musculus (house mouse)	2810403A07Rik	NP_083090.2
Homo sapiens (human)	KIAA0907	NP_055764.2
Bos taurus (cattle)	KIAA0907	NP_001076925.1
Rattus norvegicus (Norway rat)	RGD1565775	XP_342278.5

Gene Ontology
Bibliography

Related articles in PubMed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M
Cell164(4)805-17(2016 Feb)

Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.
Crisci A, Raleff F, Bagdiul I, Raabe M, Urlaub H, Rain JC, Kr?mer A
Nucleic acids research43(21)10456-73(2015 Dec)

Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis.
Mei YP, Liao JP, Shen J, Yu L, Liu BL, Liu L, Li RY, Ji L, Dorsey SG, Jiang ZR, Katz RL, Wang JY, Jiang F
Oncogene31(22)2794-804(2012 May)

Inhibition of pre-mRNA splicing by a synthetic Blom7?-interacting small RNA.
L?scher M, Schosserer M, Dausse E, Lee K, Ajuh P, Grillari-Voglauer R, Lamond AI, Toulm? JJ, Grillari J
PloS one7(10)e47497(2012)

Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4.
Grillari J, L?scher M, Denegri M, Lee K, Fortschegger K, Eisenhaber F, Ajuh P, Lamond AI, Katinger H, Grillari-Voglauer R
The Journal of biological chemistry284(42)29193-204(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results suggest that the RNA binding activity of Blom7alpha might be required for pre-mRNA splicing catalysis.
Title: Inhibition of pre-mRNA splicing by a synthetic Blom7?-interacting small RNA.

Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing and interacting with the CDC5L-SNEV(Prp19-Pso4) complex.
Title: Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4.

The following KHDC4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KHDC4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu13200	NM_014949.4 Latest version!	Homo sapiens KH domain containing 4, pre-mRNA splicing factor (KHDC4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
View Old Accession Versions >>
OHu13200	NM_014949.3	Homo sapiens KH domain containing 4, pre-mRNA splicing factor (KHDC4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KHDC4 ( NM_014949.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055764.2 Homo sapiens KH domain containing 4, pre-mRNA splicing factor (KHDC4), mRNA.

Price & Availability↑

CloneID	OHu13200
Clone ID Related Accession (Same CDS sequence)	NM_014949.3 , NM_014949.4
Accession Version	NM_014949.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	protein BLOM7
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI560023.1, BC062637.1 and AW206574.1. On Jan 29, 2015 this sequence version replaced NM_014949.2. ##Evidence-Data-START## Transcript exon combination :: BC062637.1, SRR1163657.390659.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCCGCGG GGAGCGCGAC ACATCCTGGA GCTGGCGGGC GCCGCAGCAA ATGGGACCAA 
CCAGCTCCAG CCCCACTTCT CTTCCTCCCG CCAGCGGCCC CAGGTGGGGA GGTCACCAGC 
AGTGGGGGAA GTCCTGGGGG CACCACAGCT GCTCCTTCAG GAGCCTTGGA TGCTGCTGCT 
GCTGTGGCTG CCAAGATTAA TGCCATGCTC ATGGCAAAAG GGAAGCTGAA ACCAACTCAG 
AATGCTTCTG AGAAGCTTCA GGCTCCTGGC AAAGGCCTAA CTAGCAATAA AAGCAAGGAT 
GACCTGGTGG TAGCTGAAGT AGAAATTAAT GATGTGCCTC TCACATGTAG GAACTTGCTG 
ACTCGAGGAC AGACTCAAGA CGAGATCAGC CGACTTAGTG GGGCTGCAGT ATCAACTCGA 
GGGAGGTTCA TGACAACTGA GGAAAAAGCC AAAGTGGGAC CAGGGGATCG TCCATTATAT 
CTTCATGTTC AGGGCCAGAC ACGGGAATTA GTGGACAGAG CTGTAAACCG GATCAAAGAA 
ATTATCACCA ATGGAGTGGT AAAAGCTGCC ACAGGAACAA GTCCAACTTT TAATGGTGCA 
ACAGTAACTG TCTATCACCA GCCAGCACCC ATCGCTCAGT TGTCTCCAGC TGTTAGCCAG 
AAGCCTCCCT TCCAGTCAGG GATGCATTAT GTTCAAGATA AATTATTTGT GGGTCTAGAA 
CATGCTGTAC CCACTTTTAA TGTCAAGGAG AAGGTGGAAG GTCCAGGCTG CTCCTATTTG 
CAGCACATTC AGATTGAAAC AGGTGCCAAA GTCTTCCTGC GGGGCAAAGG TTCAGGCTGC 
ATTGAGCCAG CATCTGGCCG AGAAGCTTTT GAACCTATGT ATATTTACAT CAGTCACCCC 
AAACCAGAAG GCCTGGCTGC TGCCAAGAAG CTTTGTGAGA ATCTTTTGCA AACAGTTCAT 
GCTGAATACT CTAGATTTGT GAATCAGATT AATACTGCTG TACCTTTACC AGGCTATACA 
CAACCCTCTG CTATAAGTAG TGTCCCTCCT CAACCACCAT ATTATCCATC CAATGGCTAT 
CAGTCTGGTT ACCCTGTTGT TCCCCCTCCT CAGCAGCCAG TTCAACCTCC CTACGGAGTA 
CCAAGCATAG TGCCACCAGC TGTTTCATTA GCACCTGGAG TCTTGCCGGC ATTACCTACT 
GGAGTCCCAC CTGTGCCAAC ACAATACCCG ATAACACAAG TGCAGCCTCC AGCTAGCACT 
GGACAGAGTC CGATGGGTGG TCCTTTTATT CCTGCTGCTC CTGTCAAAAC TGCCTTGCCT 
GCTGGCCCCC AGCCCCAGCC CCAGCCCCAG CCCCCACTCC CAAGTCAGCC CCAGGCACAG 
AAGAGACGAT TCACAGAGGA GCTACCAGAT GAACGGGAAT CTGGACTGCT TGGATACCAG 
CATGGACCCA TTCATATGAC TAATTTAGGT ACAGGCTTCT CCAGTCAGAA TGAGATTGAA 
GGTGCAGGAT CGAAGCCAGC AAGTTCCTCA GGCAAAGAGA GAGAGAGGGA CAGGCAGTTG 
ATGCCTCCAC CAGCCTTTCC AGTGACTGGA ATAAAAACAG AGTCCGATGA AAGGAATGGG 
TCTGGGACCT TAACAGGGAG CCATGATTAT CCAGCCAAGA AGATGAAAAC TACAGAGAAG 
GGATTTGGCT TGGTGGCTTA TGCTGCAGAT TCATCTGATG AAGAGGAGGA ACATGGAGGT 
CATAAAAATG CAAGTAGTTT TCCACAGGGC TGGAGTTTGG GATACCAATA TCCTTCATCA 
CAACCACGAG CTAAACAACA GATGCCATTC TGGATGGCTC CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055764.2
CDS	70..1914
Translation	MSAGSATHPGAGGRRSKWDQPAPAPLLFLPPAAPGGEVTSSGGSPGGTTAAPSGALDAAAAVAAKINAMLMAKGKLKPTQNASEKLQAPGKGLTSNKSKDDLVVAEVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMTTEEKAKVGPGDRPLYLHVQGQTRELVDRAVNRIKEIITNGVVKAATGTSPTFNGATVTVYHQPAPIAQLSPAVSQKPPFQSGMHYVQDKLFVGLEHAVPTFNVKEKVEGPGCSYLQHIQIETGAKVFLRGKGSGCIEPASGREAFEPMYIYISHPKPEGLAAAKKLCENLLQTVHAEYSRFVNQINTAVPLPGYTQPSAISSVPPQPPYYPSNGYQSGYPVVPPPQQPVQPPYGVPSIVPPAVSLAPGVLPALPTGVPPVPTQYPITQVQPPASTGQSPMGGPFIPAAPVKTALPAGPQPQPQPQPPLPSQPQAQKRRFTEELPDERESGLLGYQHGPIHMTNLGTGFSSQNEIEGAGSKPASSSGKERERDRQLMPPPAFPVTGIKTESDERNGSGTLTGSHDYPAKKMKTTEKGFGLVAYAADSSDEEEEHGGHKNASSFPQGWSLGYQYPSSQPRAKQQMPFWMAP

Target ORF information:

RefSeq Version	NM_014949.3
Organism	Homo sapiens(human)
Definition	Homo sapiens KH domain containing 4, pre-mRNA splicing factor (KHDC4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014949.3

ORF Insert Sequence:

ATGTCCGCGG GGAGCGCGAC ACATCCTGGA GCTGGCGGGC GCCGCAGCAA ATGGGACCAA 
CCAGCTCCAG CCCCACTTCT CTTCCTCCCG CCAGCGGCCC CAGGTGGGGA GGTCACCAGC 
AGTGGGGGAA GTCCTGGGGG CACCACAGCT GCTCCTTCAG GAGCCTTGGA TGCTGCTGCT 
GCTGTGGCTG CCAAGATTAA TGCCATGCTC ATGGCAAAAG GGAAGCTGAA ACCAACTCAG 
AATGCTTCTG AGAAGCTTCA GGCTCCTGGC AAAGGCCTAA CTAGCAATAA AAGCAAGGAT 
GACCTGGTGG TAGCTGAAGT AGAAATTAAT GATGTGCCTC TCACATGTAG GAACTTGCTG 
ACTCGAGGAC AGACTCAAGA CGAGATCAGC CGACTTAGTG GGGCTGCAGT ATCAACTCGA 
GGGAGGTTCA TGACAACTGA GGAAAAAGCC AAAGTGGGAC CAGGGGATCG TCCATTATAT 
CTTCATGTTC AGGGCCAGAC ACGGGAATTA GTGGACAGAG CTGTAAACCG GATCAAAGAA 
ATTATCACCA ATGGAGTGGT AAAAGCTGCC ACAGGAACAA GTCCAACTTT TAATGGTGCA 
ACAGTAACTG TCTATCACCA GCCAGCACCC ATCGCTCAGT TGTCTCCAGC TGTTAGCCAG 
AAGCCTCCCT TCCAGTCAGG GATGCATTAT GTTCAAGATA AATTATTTGT GGGTCTAGAA 
CATGCTGTAC CCACTTTTAA TGTCAAGGAG AAGGTGGAAG GTCCAGGCTG CTCCTATTTG 
CAGCACATTC AGATTGAAAC AGGTGCCAAA GTCTTCCTGC GGGGCAAAGG TTCAGGCTGC 
ATTGAGCCAG CATCTGGCCG AGAAGCTTTT GAACCTATGT ATATTTACAT CAGTCACCCC 
AAACCAGAAG GCCTGGCTGC TGCCAAGAAG CTTTGTGAGA ATCTTTTGCA AACAGTTCAT 
GCTGAATACT CTAGATTTGT GAATCAGATT AATACTGCTG TACCTTTACC AGGCTATACA 
CAACCCTCTG CTATAAGTAG TGTCCCTCCT CAACCACCAT ATTATCCATC CAATGGCTAT 
CAGTCTGGTT ACCCTGTTGT TCCCCCTCCT CAGCAGCCAG TTCAACCTCC CTACGGAGTA 
CCAAGCATAG TGCCACCAGC TGTTTCATTA GCACCTGGAG TCTTGCCGGC ATTACCTACT 
GGAGTCCCAC CTGTGCCAAC ACAATACCCG ATAACACAAG TGCAGCCTCC AGCTAGCACT 
GGACAGAGTC CGATGGGTGG TCCTTTTATT CCTGCTGCTC CTGTCAAAAC TGCCTTGCCT 
GCTGGCCCCC AGCCCCAGCC CCAGCCCCAG CCCCCACTCC CAAGTCAGCC CCAGGCACAG 
AAGAGACGAT TCACAGAGGA GCTACCAGAT GAACGGGAAT CTGGACTGCT TGGATACCAG 
CATGGACCCA TTCATATGAC TAATTTAGGT ACAGGCTTCT CCAGTCAGAA TGAGATTGAA 
GGTGCAGGAT CGAAGCCAGC AAGTTCCTCA GGCAAAGAGA GAGAGAGGGA CAGGCAGTTG 
ATGCCTCCAC CAGCCTTTCC AGTGACTGGA ATAAAAACAG AGTCCGATGA AAGGAATGGG 
TCTGGGACCT TAACAGGGAG CCATGATTAT CCAGCCAAGA AGATGAAAAC TACAGAGAAG 
GGATTTGGCT TGGTGGCTTA TGCTGCAGAT TCATCTGATG AAGAGGAGGA ACATGGAGGT 
CATAAAAATG CAAGTAGTTT TCCACAGGGC TGGAGTTTGG GATACCAATA TCCTTCATCA 
CAACCACGAG CTAAACAACA GATGCCATTC TGGATGGCTC CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KHDC4 ( NM_014949.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055764.2 Homo sapiens KH domain containing 4, pre-mRNA splicing factor (KHDC4), mRNA.

Price & Availability↑

CloneID	OHu13200
Clone ID Related Accession (Same CDS sequence)	NM_014949.3 , NM_014949.4
Accession Version	NM_014949.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1845bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	KH homology domain-containing protein 4
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BI560023.1 and BC062637.1. On Nov 22, 2018 this sequence version replaced NM_014949.3. ##Evidence-Data-START## Transcript exon combination :: BC062637.1, SRR1163657.390659.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000368321.8/ ENSP00000357304.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCGCGG GGAGCGCGAC ACATCCTGGA GCTGGCGGGC GCCGCAGCAA ATGGGACCAA 
CCAGCTCCAG CCCCACTTCT CTTCCTCCCG CCAGCGGCCC CAGGTGGGGA GGTCACCAGC 
AGTGGGGGAA GTCCTGGGGG CACCACAGCT GCTCCTTCAG GAGCCTTGGA TGCTGCTGCT 
GCTGTGGCTG CCAAGATTAA TGCCATGCTC ATGGCAAAAG GGAAGCTGAA ACCAACTCAG 
AATGCTTCTG AGAAGCTTCA GGCTCCTGGC AAAGGCCTAA CTAGCAATAA AAGCAAGGAT 
GACCTGGTGG TAGCTGAAGT AGAAATTAAT GATGTGCCTC TCACATGTAG GAACTTGCTG 
ACTCGAGGAC AGACTCAAGA CGAGATCAGC CGACTTAGTG GGGCTGCAGT ATCAACTCGA 
GGGAGGTTCA TGACAACTGA GGAAAAAGCC AAAGTGGGAC CAGGGGATCG TCCATTATAT 
CTTCATGTTC AGGGCCAGAC ACGGGAATTA GTGGACAGAG CTGTAAACCG GATCAAAGAA 
ATTATCACCA ATGGAGTGGT AAAAGCTGCC ACAGGAACAA GTCCAACTTT TAATGGTGCA 
ACAGTAACTG TCTATCACCA GCCAGCACCC ATCGCTCAGT TGTCTCCAGC TGTTAGCCAG 
AAGCCTCCCT TCCAGTCAGG GATGCATTAT GTTCAAGATA AATTATTTGT GGGTCTAGAA 
CATGCTGTAC CCACTTTTAA TGTCAAGGAG AAGGTGGAAG GTCCAGGCTG CTCCTATTTG 
CAGCACATTC AGATTGAAAC AGGTGCCAAA GTCTTCCTGC GGGGCAAAGG TTCAGGCTGC 
ATTGAGCCAG CATCTGGCCG AGAAGCTTTT GAACCTATGT ATATTTACAT CAGTCACCCC 
AAACCAGAAG GCCTGGCTGC TGCCAAGAAG CTTTGTGAGA ATCTTTTGCA AACAGTTCAT 
GCTGAATACT CTAGATTTGT GAATCAGATT AATACTGCTG TACCTTTACC AGGCTATACA 
CAACCCTCTG CTATAAGTAG TGTCCCTCCT CAACCACCAT ATTATCCATC CAATGGCTAT 
CAGTCTGGTT ACCCTGTTGT TCCCCCTCCT CAGCAGCCAG TTCAACCTCC CTACGGAGTA 
CCAAGCATAG TGCCACCAGC TGTTTCATTA GCACCTGGAG TCTTGCCGGC ATTACCTACT 
GGAGTCCCAC CTGTGCCAAC ACAATACCCG ATAACACAAG TGCAGCCTCC AGCTAGCACT 
GGACAGAGTC CGATGGGTGG TCCTTTTATT CCTGCTGCTC CTGTCAAAAC TGCCTTGCCT 
GCTGGCCCCC AGCCCCAGCC CCAGCCCCAG CCCCCACTCC CAAGTCAGCC CCAGGCACAG 
AAGAGACGAT TCACAGAGGA GCTACCAGAT GAACGGGAAT CTGGACTGCT TGGATACCAG 
CATGGACCCA TTCATATGAC TAATTTAGGT ACAGGCTTCT CCAGTCAGAA TGAGATTGAA 
GGTGCAGGAT CGAAGCCAGC AAGTTCCTCA GGCAAAGAGA GAGAGAGGGA CAGGCAGTTG 
ATGCCTCCAC CAGCCTTTCC AGTGACTGGA ATAAAAACAG AGTCCGATGA AAGGAATGGG 
TCTGGGACCT TAACAGGGAG CCATGATTAT CCAGCCAAGA AGATGAAAAC TACAGAGAAG 
GGATTTGGCT TGGTGGCTTA TGCTGCAGAT TCATCTGATG AAGAGGAGGA ACATGGAGGT 
CATAAAAATG CAAGTAGTTT TCCACAGGGC TGGAGTTTGG GATACCAATA TCCTTCATCA 
CAACCACGAG CTAAACAACA GATGCCATTC TGGATGGCTC CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055764.2
CDS	41..1885
Translation	MSAGSATHPGAGGRRSKWDQPAPAPLLFLPPAAPGGEVTSSGGSPGGTTAAPSGALDAAAAVAAKINAMLMAKGKLKPTQNASEKLQAPGKGLTSNKSKDDLVVAEVEINDVPLTCRNLLTRGQTQDEISRLSGAAVSTRGRFMTTEEKAKVGPGDRPLYLHVQGQTRELVDRAVNRIKEIITNGVVKAATGTSPTFNGATVTVYHQPAPIAQLSPAVSQKPPFQSGMHYVQDKLFVGLEHAVPTFNVKEKVEGPGCSYLQHIQIETGAKVFLRGKGSGCIEPASGREAFEPMYIYISHPKPEGLAAAKKLCENLLQTVHAEYSRFVNQINTAVPLPGYTQPSAISSVPPQPPYYPSNGYQSGYPVVPPPQQPVQPPYGVPSIVPPAVSLAPGVLPALPTGVPPVPTQYPITQVQPPASTGQSPMGGPFIPAAPVKTALPAGPQPQPQPQPPLPSQPQAQKRRFTEELPDERESGLLGYQHGPIHMTNLGTGFSSQNEIEGAGSKPASSSGKERERDRQLMPPPAFPVTGIKTESDERNGSGTLTGSHDYPAKKMKTTEKGFGLVAYAADSSDEEEEHGGHKNASSFPQGWSLGYQYPSSQPRAKQQMPFWMAP

Target ORF information:

RefSeq Version	NM_014949.4
Organism	Homo sapiens(human)
Definition	Homo sapiens KH domain containing 4, pre-mRNA splicing factor (KHDC4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014949.4

ORF Insert Sequence:

ATGTCCGCGG GGAGCGCGAC ACATCCTGGA GCTGGCGGGC GCCGCAGCAA ATGGGACCAA 
CCAGCTCCAG CCCCACTTCT CTTCCTCCCG CCAGCGGCCC CAGGTGGGGA GGTCACCAGC 
AGTGGGGGAA GTCCTGGGGG CACCACAGCT GCTCCTTCAG GAGCCTTGGA TGCTGCTGCT 
GCTGTGGCTG CCAAGATTAA TGCCATGCTC ATGGCAAAAG GGAAGCTGAA ACCAACTCAG 
AATGCTTCTG AGAAGCTTCA GGCTCCTGGC AAAGGCCTAA CTAGCAATAA AAGCAAGGAT 
GACCTGGTGG TAGCTGAAGT AGAAATTAAT GATGTGCCTC TCACATGTAG GAACTTGCTG 
ACTCGAGGAC AGACTCAAGA CGAGATCAGC CGACTTAGTG GGGCTGCAGT ATCAACTCGA 
GGGAGGTTCA TGACAACTGA GGAAAAAGCC AAAGTGGGAC CAGGGGATCG TCCATTATAT 
CTTCATGTTC AGGGCCAGAC ACGGGAATTA GTGGACAGAG CTGTAAACCG GATCAAAGAA 
ATTATCACCA ATGGAGTGGT AAAAGCTGCC ACAGGAACAA GTCCAACTTT TAATGGTGCA 
ACAGTAACTG TCTATCACCA GCCAGCACCC ATCGCTCAGT TGTCTCCAGC TGTTAGCCAG 
AAGCCTCCCT TCCAGTCAGG GATGCATTAT GTTCAAGATA AATTATTTGT GGGTCTAGAA 
CATGCTGTAC CCACTTTTAA TGTCAAGGAG AAGGTGGAAG GTCCAGGCTG CTCCTATTTG 
CAGCACATTC AGATTGAAAC AGGTGCCAAA GTCTTCCTGC GGGGCAAAGG TTCAGGCTGC 
ATTGAGCCAG CATCTGGCCG AGAAGCTTTT GAACCTATGT ATATTTACAT CAGTCACCCC 
AAACCAGAAG GCCTGGCTGC TGCCAAGAAG CTTTGTGAGA ATCTTTTGCA AACAGTTCAT 
GCTGAATACT CTAGATTTGT GAATCAGATT AATACTGCTG TACCTTTACC AGGCTATACA 
CAACCCTCTG CTATAAGTAG TGTCCCTCCT CAACCACCAT ATTATCCATC CAATGGCTAT 
CAGTCTGGTT ACCCTGTTGT TCCCCCTCCT CAGCAGCCAG TTCAACCTCC CTACGGAGTA 
CCAAGCATAG TGCCACCAGC TGTTTCATTA GCACCTGGAG TCTTGCCGGC ATTACCTACT 
GGAGTCCCAC CTGTGCCAAC ACAATACCCG ATAACACAAG TGCAGCCTCC AGCTAGCACT 
GGACAGAGTC CGATGGGTGG TCCTTTTATT CCTGCTGCTC CTGTCAAAAC TGCCTTGCCT 
GCTGGCCCCC AGCCCCAGCC CCAGCCCCAG CCCCCACTCC CAAGTCAGCC CCAGGCACAG 
AAGAGACGAT TCACAGAGGA GCTACCAGAT GAACGGGAAT CTGGACTGCT TGGATACCAG 
CATGGACCCA TTCATATGAC TAATTTAGGT ACAGGCTTCT CCAGTCAGAA TGAGATTGAA 
GGTGCAGGAT CGAAGCCAGC AAGTTCCTCA GGCAAAGAGA GAGAGAGGGA CAGGCAGTTG 
ATGCCTCCAC CAGCCTTTCC AGTGACTGGA ATAAAAACAG AGTCCGATGA AAGGAATGGG 
TCTGGGACCT TAACAGGGAG CCATGATTAT CCAGCCAAGA AGATGAAAAC TACAGAGAAG 
GGATTTGGCT TGGTGGCTTA TGCTGCAGAT TCATCTGATG AAGAGGAGGA ACATGGAGGT 
CATAAAAATG CAAGTAGTTT TCCACAGGGC TGGAGTTTGG GATACCAATA TCCTTCATCA 
CAACCACGAG CTAAACAACA GATGCCATTC TGGATGGCTC CCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
Cell164(4)805-17(2016 Feb)
Yang X,Coulombe-Huntington J,Kang S,Sheynkman GM,Hao T,Richardson A,Sun S,Yang F,Shen YA,Murray RR,Spirohn K,Begg BE,Duran-Frigola M,MacWilliams A,Pevzner SJ,Zhong Q,Trigg SA,Tam S,Ghamsari L,Sahni N,Yi S,Rodriguez MD,Balcha D,Tan G,Costanzo M,Andrews B,Boone C,Zhou XJ,Salehi-Ashtiani K,Charloteaux B,Chen AA,Calderwood MA,Aloy P,Roth FP,Hill DE,Iakoucheva LM,Xia Y,Vidal M

Mammalian splicing factor SF1 interacts with SURP domains of U2 snRNP-associated proteins.
Nucleic acids research43(21)10456-73(2015 Dec)
Crisci A,Raleff F,Bagdiul I,Raabe M,Urlaub H,Rain JC,Kr?mer A

Small nucleolar RNA 42 acts as an oncogene in lung tumorigenesis.
Oncogene31(22)2794-804(2012 May)
Mei YP,Liao JP,Shen J,Yu L,Liu BL,Liu L,Li RY,Ji L,Dorsey SG,Jiang ZR,Katz RL,Wang JY,Jiang F

Inhibition of pre-mRNA splicing by a synthetic Blom7?-interacting small RNA.
PloS one7(10)e47497(2012)
L?scher M,Schosserer M,Dausse E,Lee K,Ajuh P,Grillari-Voglauer R,Lamond AI,Toulm? JJ,Grillari J

Blom7alpha is a novel heterogeneous nuclear ribonucleoprotein K homology domain protein involved in pre-mRNA splicing that interacts with SNEVPrp19-Pso4.
The Journal of biological chemistry284(42)29193-204(2009 Oct)
Grillari J,L?scher M,Denegri M,Lee K,Fortschegger K,Eisenhaber F,Ajuh P,Lamond AI,Katinger H,Grillari-Voglauer R

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KHDC4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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