PPP6R1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PPP6R1
Entrez Gene ID	22870
Full Name	protein phosphatase 6 regulatory subunit 1
Synonyms	KIAA1115,PP6R1,SAP190,SAPS1
General protein information	Preferred Names protein phosphatase 6 regulatory subunit 1 Names serine/threonine-protein phosphatase 6 regulatory subunit 1 SAPS domain family, member 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.42
Summary	Protein phosphatase regulatory subunits, such as SAPS1, modulate the activity of protein phosphatase catalytic subunits by restricting substrate specificity, recruiting substrates, and determining the intracellular localization of the holoenzyme. SAPS1 is a regulatory subunit for the protein phosphatase-6 catalytic subunit (PPP6C; MIM 612725) (Stefansson and Brautigan, 2006 [PubMed 16769727]).[supplied by OMIM, Nov 2010].
Disorder MIM:	610875

mRNA and Protein(s)

mRNA	Protein	Name
NM_014931.3	NP_055746.3	serine/threonine-protein phosphatase 6 regulatory subunit 1
NM_014931.4	NP_055746.3	serine/threonine-protein phosphatase 6 regulatory subunit 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	PPP6R1	NP_055746.3
Mus musculus (house mouse)	Ppp6r1	NP_766482.2
Xenopus tropicalis (tropical clawed frog)	ppp6r1	XP_002939288.2
Pan troglodytes (chimpanzee)	PPP6R1	XP_001135264.2
Rattus norvegicus (Norway rat)	Ppp6r1	NP_001129321.1
	PPP6R1	XP_002801454.1
Canis lupus familiaris (dog)	PPP6R1	XP_005616239.1

Gene Ontology
Bibliography

Related articles in PubMed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Yadav L, Tamene F, G??s H, van Drogen A, Katainen R, Aebersold R, Gstaiger M, Varjosalo M
Cell systems4(4)430-444.e5(2017 Apr)

CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling.
Lant B, Yu B, Goudreault M, Holmyard D, Knight JD, Xu P, Zhao L, Chin K, Wallace E, Zhen M, Gingras AC, Derry WB
Nature communications66449(2015 Mar)

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
Couzens AL, Knight JD, Kean MJ, Teo G, Weiss A, Dunham WH, Lin ZY, Bagshaw RD, Sicheri F, Pawson T, Wrana JL, Choi H, Gingras AC
Science signaling6(302)rs15(2013 Nov)

PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase.
Hosing AS, Valerie NC, Dziegielewski J, Brautigan DL, Larner JM
The Journal of biological chemistry287(12)9230-9(2012 Mar)

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.
Zeng K, Bastos RN, Barr FA, Gruneberg U
The Journal of cell biology191(7)1315-32(2010 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase.
Title: PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase.

The following PPP6R1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PPP6R1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06742	NM_014931.4 Latest version!	Homo sapiens protein phosphatase 6 regulatory subunit 1 (PPP6R1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
View Old Accession Versions >>
OHu06742	NM_014931.3	Homo sapiens protein phosphatase 6 regulatory subunit 1 (PPP6R1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PPP6R1 ( NM_014931.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055746.3 Homo sapiens protein phosphatase 6 regulatory subunit 1 (PPP6R1), mRNA.

Price & Availability↑

CloneID	OHu06742
Clone ID Related Accession (Same CDS sequence)	NM_014931.3 , NM_014931.4
Accession Version	NM_014931.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2646bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	serine/threonine-protein phosphatase 6 regulatory subunit 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL544921.3, AC116342.2, BG772019.1, BC002799.2 and AC010327.8. On Jul 5, 2007 this sequence version replaced NM_014931.2. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.171589.1, AB029038.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTTTTGGA AGTTTGACCT GCACACAAGC TCGCACCTGG ACACGCTGCT GGAGCGGGAG 
GACCTGAGCC TGCCCGAGCT GCTGGACGAG GAAGACGTGC TGCAGGAGTG CAAGGTCGTC 
AACCGCAAGC TGCTGGACTT CCTGCTGCAG CCACCCCACC TGCAAGCAAT GGTGGCCTGG 
GTCACCCAGG AGCCGCCAGA TAGCGGTGAG GAGCGGCTGC GCTACAAGTA CCCCAGTGTG 
GCCTGCGAGA TTCTGACCTC AGATGTGCCC CAGATCAATG ATGCCCTGGG TGCTGATGAG 
TCCCTTCTGA ACCGGCTCTA CGGCTTCCTG CAGAGCACCG GCAGCCTCAA CCCACTGCTG 
GCCAGCTTCT TCAGCAAGGT CATGGGCATC CTCATCAACC GCAAGACAGA CCAGCTCGTG 
TCCTTTCTTC GGAAGAAGGA TGACTTCGTG GACCTGCTGC TGCAGCACAT TGGCACCTCG 
GCCATCATGG ACCTCCTGCT GCGCCTGCTC ACCTGTGTGG AGCGGCCTCA GCTGAGGCAG 
GATGTTGTCA ATTGGCTCAA CGAGGAGAAG ATCGTCCAGC GGCTGATTGA GCAGATCCAC 
CCGTCGAAGG ATGAGAATCA ACATTCCAAC GCATCCCAGT CCCTGTGTGA CATCATCCGC 
CTGAGCCGGG AGCAGATGAT CCAAGTCCAG GACAGCCCAG AGCCTGACCA ACTGCTGGCC 
ACCCTGGAGA AGCAGGAGAC GATTGAGCAG CTCTTAAGCA ACATGTTCGA GGGGGAGCAG 
AGCCAGTCTG TCATCGTCAG TGGGATCCAG GTGCTGCTGA CCCTGCTGGA GCCCAGGAGG 
CCGAGGTCCG AGTCCGTGAC CGTGAACAGC TTCTTCAGCA GTGTGGATGG GCAGCTGGAG 
CTCCTGGCCC AGGGGGCCCT GGAAAGCACT GTGTCCAGTG TGGGCGCCTT GCACGCCCTA 
CGCCCGCGGC TCAGCTGCTT CCACCAGCTC CTGCTGGAGC CTCCCAAGCT GGAGCCGCTA 
CAGATGACAT GGGGCATGCT GGCTCCGCCT CTGGGCAACA CGCGGCTGCA CGTGGTCAAG 
CTCCTGGCCA GTGCCCTGAG CGCCAATGAT GCAGCCCTGA CGCACGAGCT CCTGGCACTG 
GACGTGCCCA ACACCATGCT GGACCTCTTC TTCCATTATG TCTTCAACAA CTTCTTGCAT 
GCCCAAGTAG AGGGATGCGT GAGCACCATG CTGAGCTTGG GGCCACCTCC TGACAGCAGC 
CCTGAGACGC CCATCCAAAA CCCTGTTGTG AAACATCTGC TGCAGCAGTG CCGCCTGGTG 
GAGCGGATCC TGACGTCCTG GGAGGAGAAC GACCGTGTAC AGTGTGCGGG AGGCCCTCGG 
AAAGGCTACA TGGGTCACCT GACAAGAGTG GCCGGTGCCC TGGTGCAGAA CACGGAGAAG 
GGGCCCAATG CAGAGCAGCT GCGGCAGCTG CTGAAGGAGC TGCCCAGCGA GCAGCAGGAG 
CAGTGGGAAG CCTTCGTATC GGGGCCCCTG GCGGAGACCA ACAAGAAGAA CATGGTGGAC 
CTGGTGAACA CCCACCACCT ACACTCCTCC AGTGACGATG AGGACGACCG GCTCAAGGAG 
TTCAACTTCC CTGAGGAGGC TGTGCTGCAG CAGGCCTTCA TGGACTTCCA GATGCAGCGC 
ATGACCTCTG CCTTCATTGA CCACTTCGGC TTCAATGATG AGGAGTTTGG GGAGCAGGAG 
GAGAGTGTGA ACGCACCTTT TGACAAGACA GCCAACATCA CCTTCTCCCT CAATGCTGAC 
GATGAGAACC CCAACGCCAA CCTACTTGAG ATATGCTACA AGGACCGCAT CCAGCAGTTT 
GATGATGATG AGGAAGAGGA GGACGAGGAA GAGGCCCAGG GCTCAGGGGA GTCTGATGGA 
GAAGATGGCG CCTGGCAGGG CAGCCAGCTG GCCAGGGGGG CCCGTCTGGG CCAGCCACCT 
GGTGTCCGGA GTGGAGGCAG CACAGACAGT GAGGACGAAG AAGAGGAGGA CGAGGAGGAG 
GAGGAAGACG AGGAGGGCAT TGGCTGTGCA GCCCGTGGAG GGGCCACCCC TCTGTCCTAC 
CCCAGCCCTG GCCCTCAGCC TCCAGGCCCC AGCTGGACAG CCACCTTTGA CCCAGTGCCT 
ACAGATGCCC CGACCAGCCC CCGAGTCTCC GGGGAGGAAG AGCTGCACAC TGGGCCTCCA 
GCCCCACAGG GGCCCCTCAG TGTGCCCCAG GGCCTCCCCA CTCAGAGCCT GGCCAGCCCT 
CCTGCCCGTG ACGCCCTGCA GCTCAGGTCT CAGGACCCCA CACCCCCCTC AGCACCTCAG 
GAAGCCACAG AAGGCAGCAA AGTCACGGAG CCCTCAGCCC CTTGCCAGGC CTTGGTTAGC 
ATCGGGGACC TTCAGGCCAC CTTCCACGGG ATCCGTTCTG CCCCCAGCTC CTCGGACAGT 
GCAACCAGAG ACCCCTCTAC CTCTGTCCCA GCCTCCGGGG CCCACCAGCC CCCCCAGACC 
ACAGAAGGGG AGAAGAGCCC AGAGCCCTTG GGGCTTCCCC AAAGCCAGAG TGCCCAGGCC 
CTCACGCCTC CTCCGATACC CAATGGCTCT GCCCCGGAAG GGCCTGCATC CCCAGGCTCC 
CAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055746.3
CDS	243..2888
Translation	MFWKFDLHTSSHLDTLLEREDLSLPELLDEEDVLQECKVVNRKLLDFLLQPPHLQAMVAWVTQEPPDSGEERLRYKYPSVACEILTSDVPQINDALGADESLLNRLYGFLQSTGSLNPLLASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVERPQLRQDVVNWLNEEKIVQRLIEQIHPSKDENQHSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVLLTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSLGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQWEAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDDEEEEDEEEAQGSGESDGEDGAWQGSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEEDEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGPASPGSQ

Target ORF information:

RefSeq Version	NM_014931.3
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 6 regulatory subunit 1 (PPP6R1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014931.3

ORF Insert Sequence:

ATGTTTTGGA AGTTTGACCT GCACACAAGC TCGCACCTGG ACACGCTGCT GGAGCGGGAG 
GACCTGAGCC TGCCCGAGCT GCTGGACGAG GAAGACGTGC TGCAGGAGTG CAAGGTCGTC 
AACCGCAAGC TGCTGGACTT CCTGCTGCAG CCACCCCACC TGCAAGCAAT GGTGGCCTGG 
GTCACCCAGG AGCCGCCAGA TAGCGGTGAG GAGCGGCTGC GCTACAAGTA CCCCAGTGTG 
GCCTGCGAGA TTCTGACCTC AGATGTGCCC CAGATCAATG ATGCCCTGGG TGCTGATGAG 
TCCCTTCTGA ACCGGCTCTA CGGCTTCCTG CAGAGCACCG GCAGCCTCAA CCCACTGCTG 
GCCAGCTTCT TCAGCAAGGT CATGGGCATC CTCATCAACC GCAAGACAGA CCAGCTCGTG 
TCCTTTCTTC GGAAGAAGGA TGACTTCGTG GACCTGCTGC TGCAGCACAT TGGCACCTCG 
GCCATCATGG ACCTCCTGCT GCGCCTGCTC ACCTGTGTGG AGCGGCCTCA GCTGAGGCAG 
GATGTTGTCA ATTGGCTCAA CGAGGAGAAG ATCGTCCAGC GGCTGATTGA GCAGATCCAC 
CCGTCGAAGG ATGAGAATCA ACATTCCAAC GCATCCCAGT CCCTGTGTGA CATCATCCGC 
CTGAGCCGGG AGCAGATGAT CCAAGTCCAG GACAGCCCAG AGCCTGACCA ACTGCTGGCC 
ACCCTGGAGA AGCAGGAGAC GATTGAGCAG CTCTTAAGCA ACATGTTCGA GGGGGAGCAG 
AGCCAGTCTG TCATCGTCAG TGGGATCCAG GTGCTGCTGA CCCTGCTGGA GCCCAGGAGG 
CCGAGGTCCG AGTCCGTGAC CGTGAACAGC TTCTTCAGCA GTGTGGATGG GCAGCTGGAG 
CTCCTGGCCC AGGGGGCCCT GGAAAGCACT GTGTCCAGTG TGGGCGCCTT GCACGCCCTA 
CGCCCGCGGC TCAGCTGCTT CCACCAGCTC CTGCTGGAGC CTCCCAAGCT GGAGCCGCTA 
CAGATGACAT GGGGCATGCT GGCTCCGCCT CTGGGCAACA CGCGGCTGCA CGTGGTCAAG 
CTCCTGGCCA GTGCCCTGAG CGCCAATGAT GCAGCCCTGA CGCACGAGCT CCTGGCACTG 
GACGTGCCCA ACACCATGCT GGACCTCTTC TTCCATTATG TCTTCAACAA CTTCTTGCAT 
GCCCAAGTAG AGGGATGCGT GAGCACCATG CTGAGCTTGG GGCCACCTCC TGACAGCAGC 
CCTGAGACGC CCATCCAAAA CCCTGTTGTG AAACATCTGC TGCAGCAGTG CCGCCTGGTG 
GAGCGGATCC TGACGTCCTG GGAGGAGAAC GACCGTGTAC AGTGTGCGGG AGGCCCTCGG 
AAAGGCTACA TGGGTCACCT GACAAGAGTG GCCGGTGCCC TGGTGCAGAA CACGGAGAAG 
GGGCCCAATG CAGAGCAGCT GCGGCAGCTG CTGAAGGAGC TGCCCAGCGA GCAGCAGGAG 
CAGTGGGAAG CCTTCGTATC GGGGCCCCTG GCGGAGACCA ACAAGAAGAA CATGGTGGAC 
CTGGTGAACA CCCACCACCT ACACTCCTCC AGTGACGATG AGGACGACCG GCTCAAGGAG 
TTCAACTTCC CTGAGGAGGC TGTGCTGCAG CAGGCCTTCA TGGACTTCCA GATGCAGCGC 
ATGACCTCTG CCTTCATTGA CCACTTCGGC TTCAATGATG AGGAGTTTGG GGAGCAGGAG 
GAGAGTGTGA ACGCACCTTT TGACAAGACA GCCAACATCA CCTTCTCCCT CAATGCTGAC 
GATGAGAACC CCAACGCCAA CCTACTTGAG ATATGCTACA AGGACCGCAT CCAGCAGTTT 
GATGATGATG AGGAAGAGGA GGACGAGGAA GAGGCCCAGG GCTCAGGGGA GTCTGATGGA 
GAAGATGGCG CCTGGCAGGG CAGCCAGCTG GCCAGGGGGG CCCGTCTGGG CCAGCCACCT 
GGTGTCCGGA GTGGAGGCAG CACAGACAGT GAGGACGAAG AAGAGGAGGA CGAGGAGGAG 
GAGGAAGACG AGGAGGGCAT TGGCTGTGCA GCCCGTGGAG GGGCCACCCC TCTGTCCTAC 
CCCAGCCCTG GCCCTCAGCC TCCAGGCCCC AGCTGGACAG CCACCTTTGA CCCAGTGCCT 
ACAGATGCCC CGACCAGCCC CCGAGTCTCC GGGGAGGAAG AGCTGCACAC TGGGCCTCCA 
GCCCCACAGG GGCCCCTCAG TGTGCCCCAG GGCCTCCCCA CTCAGAGCCT GGCCAGCCCT 
CCTGCCCGTG ACGCCCTGCA GCTCAGGTCT CAGGACCCCA CACCCCCCTC AGCACCTCAG 
GAAGCCACAG AAGGCAGCAA AGTCACGGAG CCCTCAGCCC CTTGCCAGGC CTTGGTTAGC 
ATCGGGGACC TTCAGGCCAC CTTCCACGGG ATCCGTTCTG CCCCCAGCTC CTCGGACAGT 
GCAACCAGAG ACCCCTCTAC CTCTGTCCCA GCCTCCGGGG CCCACCAGCC CCCCCAGACC 
ACAGAAGGGG AGAAGAGCCC AGAGCCCTTG GGGCTTCCCC AAAGCCAGAG TGCCCAGGCC 
CTCACGCCTC CTCCGATACC CAATGGCTCT GCCCCGGAAG GGCCTGCATC CCCAGGCTCC 
CAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PPP6R1 ( NM_014931.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055746.3 Homo sapiens protein phosphatase 6 regulatory subunit 1 (PPP6R1), mRNA.

Price & Availability↑

CloneID	OHu06742
Clone ID Related Accession (Same CDS sequence)	NM_014931.3 , NM_014931.4
Accession Version	NM_014931.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2646bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	serine/threonine-protein phosphatase 6 regulatory subunit 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC116342.2, AL544921.3, BG772019.1, BC002799.2 and AC010327.8. On Nov 23, 2018 this sequence version replaced NM_014931.3. ##Evidence-Data-START## Transcript exon combination :: SRR1163658.171589.1, AB029038.2 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000412770.7/ ENSP00000414202.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTTTTGGA AGTTTGACCT GCACACAAGC TCGCACCTGG ACACGCTGCT GGAGCGGGAG 
GACCTGAGCC TGCCCGAGCT GCTGGACGAG GAAGACGTGC TGCAGGAGTG CAAGGTCGTC 
AACCGCAAGC TGCTGGACTT CCTGCTGCAG CCACCCCACC TGCAAGCAAT GGTGGCCTGG 
GTCACCCAGG AGCCGCCAGA TAGCGGTGAG GAGCGGCTGC GCTACAAGTA CCCCAGTGTG 
GCCTGCGAGA TTCTGACCTC AGATGTGCCC CAGATCAATG ATGCCCTGGG TGCTGATGAG 
TCCCTTCTGA ACCGGCTCTA CGGCTTCCTG CAGAGCACCG GCAGCCTCAA CCCACTGCTG 
GCCAGCTTCT TCAGCAAGGT CATGGGCATC CTCATCAACC GCAAGACAGA CCAGCTCGTG 
TCCTTTCTTC GGAAGAAGGA TGACTTCGTG GACCTGCTGC TGCAGCACAT TGGCACCTCG 
GCCATCATGG ACCTCCTGCT GCGCCTGCTC ACCTGTGTGG AGCGGCCTCA GCTGAGGCAG 
GATGTTGTCA ATTGGCTCAA CGAGGAGAAG ATCGTCCAGC GGCTGATTGA GCAGATCCAC 
CCGTCGAAGG ATGAGAATCA ACATTCCAAC GCATCCCAGT CCCTGTGTGA CATCATCCGC 
CTGAGCCGGG AGCAGATGAT CCAAGTCCAG GACAGCCCAG AGCCTGACCA ACTGCTGGCC 
ACCCTGGAGA AGCAGGAGAC GATTGAGCAG CTCTTAAGCA ACATGTTCGA GGGGGAGCAG 
AGCCAGTCTG TCATCGTCAG TGGGATCCAG GTGCTGCTGA CCCTGCTGGA GCCCAGGAGG 
CCGAGGTCCG AGTCCGTGAC CGTGAACAGC TTCTTCAGCA GTGTGGATGG GCAGCTGGAG 
CTCCTGGCCC AGGGGGCCCT GGAAAGCACT GTGTCCAGTG TGGGCGCCTT GCACGCCCTA 
CGCCCGCGGC TCAGCTGCTT CCACCAGCTC CTGCTGGAGC CTCCCAAGCT GGAGCCGCTA 
CAGATGACAT GGGGCATGCT GGCTCCGCCT CTGGGCAACA CGCGGCTGCA CGTGGTCAAG 
CTCCTGGCCA GTGCCCTGAG CGCCAATGAT GCAGCCCTGA CGCACGAGCT CCTGGCACTG 
GACGTGCCCA ACACCATGCT GGACCTCTTC TTCCATTATG TCTTCAACAA CTTCTTGCAT 
GCCCAAGTAG AGGGATGCGT GAGCACCATG CTGAGCTTGG GGCCACCTCC TGACAGCAGC 
CCTGAGACGC CCATCCAAAA CCCTGTTGTG AAACATCTGC TGCAGCAGTG CCGCCTGGTG 
GAGCGGATCC TGACGTCCTG GGAGGAGAAC GACCGTGTAC AGTGTGCGGG AGGCCCTCGG 
AAAGGCTACA TGGGTCACCT GACAAGAGTG GCCGGTGCCC TGGTGCAGAA CACGGAGAAG 
GGGCCCAATG CAGAGCAGCT GCGGCAGCTG CTGAAGGAGC TGCCCAGCGA GCAGCAGGAG 
CAGTGGGAAG CCTTCGTATC GGGGCCCCTG GCGGAGACCA ACAAGAAGAA CATGGTGGAC 
CTGGTGAACA CCCACCACCT ACACTCCTCC AGTGACGATG AGGACGACCG GCTCAAGGAG 
TTCAACTTCC CTGAGGAGGC TGTGCTGCAG CAGGCCTTCA TGGACTTCCA GATGCAGCGC 
ATGACCTCTG CCTTCATTGA CCACTTCGGC TTCAATGATG AGGAGTTTGG GGAGCAGGAG 
GAGAGTGTGA ACGCACCTTT TGACAAGACA GCCAACATCA CCTTCTCCCT CAATGCTGAC 
GATGAGAACC CCAACGCCAA CCTACTTGAG ATATGCTACA AGGACCGCAT CCAGCAGTTT 
GATGATGATG AGGAAGAGGA GGACGAGGAA GAGGCCCAGG GCTCAGGGGA GTCTGATGGA 
GAAGATGGCG CCTGGCAGGG CAGCCAGCTG GCCAGGGGGG CCCGTCTGGG CCAGCCACCT 
GGTGTCCGGA GTGGAGGCAG CACAGACAGT GAGGACGAAG AAGAGGAGGA CGAGGAGGAG 
GAGGAAGACG AGGAGGGCAT TGGCTGTGCA GCCCGTGGAG GGGCCACCCC TCTGTCCTAC 
CCCAGCCCTG GCCCTCAGCC TCCAGGCCCC AGCTGGACAG CCACCTTTGA CCCAGTGCCT 
ACAGATGCCC CGACCAGCCC CCGAGTCTCC GGGGAGGAAG AGCTGCACAC TGGGCCTCCA 
GCCCCACAGG GGCCCCTCAG TGTGCCCCAG GGCCTCCCCA CTCAGAGCCT GGCCAGCCCT 
CCTGCCCGTG ACGCCCTGCA GCTCAGGTCT CAGGACCCCA CACCCCCCTC AGCACCTCAG 
GAAGCCACAG AAGGCAGCAA AGTCACGGAG CCCTCAGCCC CTTGCCAGGC CTTGGTTAGC 
ATCGGGGACC TTCAGGCCAC CTTCCACGGG ATCCGTTCTG CCCCCAGCTC CTCGGACAGT 
GCAACCAGAG ACCCCTCTAC CTCTGTCCCA GCCTCCGGGG CCCACCAGCC CCCCCAGACC 
ACAGAAGGGG AGAAGAGCCC AGAGCCCTTG GGGCTTCCCC AAAGCCAGAG TGCCCAGGCC 
CTCACGCCTC CTCCGATACC CAATGGCTCT GCCCCGGAAG GGCCTGCATC CCCAGGCTCC 
CAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055746.3
CDS	590..3235
Translation	MFWKFDLHTSSHLDTLLEREDLSLPELLDEEDVLQECKVVNRKLLDFLLQPPHLQAMVAWVTQEPPDSGEERLRYKYPSVACEILTSDVPQINDALGADESLLNRLYGFLQSTGSLNPLLASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVERPQLRQDVVNWLNEEKIVQRLIEQIHPSKDENQHSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVLLTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSLGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQWEAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDDEEEEDEEEAQGSGESDGEDGAWQGSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEEDEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGPASPGSQ

Target ORF information:

RefSeq Version	NM_014931.4
Organism	Homo sapiens(human)
Definition	Homo sapiens protein phosphatase 6 regulatory subunit 1 (PPP6R1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014931.4

ORF Insert Sequence:

ATGTTTTGGA AGTTTGACCT GCACACAAGC TCGCACCTGG ACACGCTGCT GGAGCGGGAG 
GACCTGAGCC TGCCCGAGCT GCTGGACGAG GAAGACGTGC TGCAGGAGTG CAAGGTCGTC 
AACCGCAAGC TGCTGGACTT CCTGCTGCAG CCACCCCACC TGCAAGCAAT GGTGGCCTGG 
GTCACCCAGG AGCCGCCAGA TAGCGGTGAG GAGCGGCTGC GCTACAAGTA CCCCAGTGTG 
GCCTGCGAGA TTCTGACCTC AGATGTGCCC CAGATCAATG ATGCCCTGGG TGCTGATGAG 
TCCCTTCTGA ACCGGCTCTA CGGCTTCCTG CAGAGCACCG GCAGCCTCAA CCCACTGCTG 
GCCAGCTTCT TCAGCAAGGT CATGGGCATC CTCATCAACC GCAAGACAGA CCAGCTCGTG 
TCCTTTCTTC GGAAGAAGGA TGACTTCGTG GACCTGCTGC TGCAGCACAT TGGCACCTCG 
GCCATCATGG ACCTCCTGCT GCGCCTGCTC ACCTGTGTGG AGCGGCCTCA GCTGAGGCAG 
GATGTTGTCA ATTGGCTCAA CGAGGAGAAG ATCGTCCAGC GGCTGATTGA GCAGATCCAC 
CCGTCGAAGG ATGAGAATCA ACATTCCAAC GCATCCCAGT CCCTGTGTGA CATCATCCGC 
CTGAGCCGGG AGCAGATGAT CCAAGTCCAG GACAGCCCAG AGCCTGACCA ACTGCTGGCC 
ACCCTGGAGA AGCAGGAGAC GATTGAGCAG CTCTTAAGCA ACATGTTCGA GGGGGAGCAG 
AGCCAGTCTG TCATCGTCAG TGGGATCCAG GTGCTGCTGA CCCTGCTGGA GCCCAGGAGG 
CCGAGGTCCG AGTCCGTGAC CGTGAACAGC TTCTTCAGCA GTGTGGATGG GCAGCTGGAG 
CTCCTGGCCC AGGGGGCCCT GGAAAGCACT GTGTCCAGTG TGGGCGCCTT GCACGCCCTA 
CGCCCGCGGC TCAGCTGCTT CCACCAGCTC CTGCTGGAGC CTCCCAAGCT GGAGCCGCTA 
CAGATGACAT GGGGCATGCT GGCTCCGCCT CTGGGCAACA CGCGGCTGCA CGTGGTCAAG 
CTCCTGGCCA GTGCCCTGAG CGCCAATGAT GCAGCCCTGA CGCACGAGCT CCTGGCACTG 
GACGTGCCCA ACACCATGCT GGACCTCTTC TTCCATTATG TCTTCAACAA CTTCTTGCAT 
GCCCAAGTAG AGGGATGCGT GAGCACCATG CTGAGCTTGG GGCCACCTCC TGACAGCAGC 
CCTGAGACGC CCATCCAAAA CCCTGTTGTG AAACATCTGC TGCAGCAGTG CCGCCTGGTG 
GAGCGGATCC TGACGTCCTG GGAGGAGAAC GACCGTGTAC AGTGTGCGGG AGGCCCTCGG 
AAAGGCTACA TGGGTCACCT GACAAGAGTG GCCGGTGCCC TGGTGCAGAA CACGGAGAAG 
GGGCCCAATG CAGAGCAGCT GCGGCAGCTG CTGAAGGAGC TGCCCAGCGA GCAGCAGGAG 
CAGTGGGAAG CCTTCGTATC GGGGCCCCTG GCGGAGACCA ACAAGAAGAA CATGGTGGAC 
CTGGTGAACA CCCACCACCT ACACTCCTCC AGTGACGATG AGGACGACCG GCTCAAGGAG 
TTCAACTTCC CTGAGGAGGC TGTGCTGCAG CAGGCCTTCA TGGACTTCCA GATGCAGCGC 
ATGACCTCTG CCTTCATTGA CCACTTCGGC TTCAATGATG AGGAGTTTGG GGAGCAGGAG 
GAGAGTGTGA ACGCACCTTT TGACAAGACA GCCAACATCA CCTTCTCCCT CAATGCTGAC 
GATGAGAACC CCAACGCCAA CCTACTTGAG ATATGCTACA AGGACCGCAT CCAGCAGTTT 
GATGATGATG AGGAAGAGGA GGACGAGGAA GAGGCCCAGG GCTCAGGGGA GTCTGATGGA 
GAAGATGGCG CCTGGCAGGG CAGCCAGCTG GCCAGGGGGG CCCGTCTGGG CCAGCCACCT 
GGTGTCCGGA GTGGAGGCAG CACAGACAGT GAGGACGAAG AAGAGGAGGA CGAGGAGGAG 
GAGGAAGACG AGGAGGGCAT TGGCTGTGCA GCCCGTGGAG GGGCCACCCC TCTGTCCTAC 
CCCAGCCCTG GCCCTCAGCC TCCAGGCCCC AGCTGGACAG CCACCTTTGA CCCAGTGCCT 
ACAGATGCCC CGACCAGCCC CCGAGTCTCC GGGGAGGAAG AGCTGCACAC TGGGCCTCCA 
GCCCCACAGG GGCCCCTCAG TGTGCCCCAG GGCCTCCCCA CTCAGAGCCT GGCCAGCCCT 
CCTGCCCGTG ACGCCCTGCA GCTCAGGTCT CAGGACCCCA CACCCCCCTC AGCACCTCAG 
GAAGCCACAG AAGGCAGCAA AGTCACGGAG CCCTCAGCCC CTTGCCAGGC CTTGGTTAGC 
ATCGGGGACC TTCAGGCCAC CTTCCACGGG ATCCGTTCTG CCCCCAGCTC CTCGGACAGT 
GCAACCAGAG ACCCCTCTAC CTCTGTCCCA GCCTCCGGGG CCCACCAGCC CCCCCAGACC 
ACAGAAGGGG AGAAGAGCCC AGAGCCCTTG GGGCTTCCCC AAAGCCAGAG TGCCCAGGCC 
CTCACGCCTC CTCCGATACC CAATGGCTCT GCCCCGGAAG GGCCTGCATC CCCAGGCTCC 
CAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics.
Cell systems4(4)430-444.e5(2017 Apr)
Yadav L,Tamene F,G??s H,van Drogen A,Katainen R,Aebersold R,Gstaiger M,Varjosalo M

CCM-3/STRIPAK promotes seamless tube extension through endocytic recycling.
Nature communications66449(2015 Mar)
Lant B,Yu B,Goudreault M,Holmyard D,Knight JD,Xu P,Zhao L,Chin K,Wallace E,Zhen M,Gingras AC,Derry WB

Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions.
Science signaling6(302)rs15(2013 Nov)
Couzens AL,Knight JD,Kean MJ,Teo G,Weiss A,Dunham WH,Lin ZY,Bagshaw RD,Sicheri F,Pawson T,Wrana JL,Choi H,Gingras AC

PP6 regulatory subunit R1 is bidentate anchor for targeting protein phosphatase-6 to DNA-dependent protein kinase.
The Journal of biological chemistry287(12)9230-9(2012 Mar)
Hosing AS,Valerie NC,Dziegielewski J,Brautigan DL,Larner JM

Protein phosphatase 6 regulates mitotic spindle formation by controlling the T-loop phosphorylation state of Aurora A bound to its activator TPX2.
The Journal of cell biology191(7)1315-32(2010 Dec)
Zeng K,Bastos RN,Barr FA,Gruneberg U

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PPP6R1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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