AAK1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AAK1
Entrez Gene ID	22848
Full Name	AP2 associated kinase 1
General protein information	Preferred Names AP2 associated kinase 1 Names AP2-associated protein kinase 1 adaptor-associated kinase 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p13.3
Summary	Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit encodytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
Disorder MIM:	616405

mRNA and Protein(s)

mRNA	Protein	Name
NM_001371577.1	NP_001358506.1	AP2-associated protein kinase 1 isoform 3
NM_014911.4	NP_055726.3	AP2-associated protein kinase 1 isoform 1
NM_001371575.1	NP_001358504.1	AP2-associated protein kinase 1 isoform 2
NM_014911.3	NP_055726.3	AP2-associated protein kinase 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	AAK1	XP_001138187.3
Rattus norvegicus (Norway rat)	Aak1	NP_001166921.1
Homo sapiens (human)	AAK1	NP_055726.3
Gallus gallus (chicken)	AAK1	XP_417663.4
Canis lupus familiaris (dog)	AAK1	XP_005626238.1
Mus musculus (house mouse)	Aak1	NP_001035195.1

Gene Ontology
Bibliography

Related articles in PubMed

Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.
Sorrell FJ, Szklarz M, Abdul Azeez KR, Elkins JM, Knapp S
Structure (London, England : 1993)24(3)401-11(2016 Mar)

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
So J, Pasculescu A, Dai AY, Williton K, James A, Nguyen V, Creixell P, Schoof EM, Sinclair J, Barrios-Rodiles M, Gu J, Krizus A, Williams R, Olhovsky M, Dennis JW, Wrana JL, Linding R, Jorgensen C, Pawson T, Colwill K
Science signaling8(371)rs3(2015 Apr)

AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.
Neveu G, Ziv-Av A, Barouch-Bentov R, Berkerman E, Mulholland J, Einav S
Journal of virology89(8)4387-404(2015 Apr)

Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network.
Malinowski JR, Denny JC, Bielinski SJ, Basford MA, Bradford Y, Peissig PL, Carrell D, Crosslin DR, Pathak J, Rasmussen L, Pacheco J, Kho A, Newton KM, Li R, Kullo IJ, Chute CG, Chisholm RL, Jarvik GP, Larson EB, McCarty CA, Masys DR, Roden DM, de Andrade M, Ritchie MD, Crawford DC
PloS one9(12)e111301(2014)

Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
Yu B, Zheng Y, Alexander D, Manolio TA, Alonso A, Nettleton JA, Boerwinkle E
Genetic epidemiology37(8)840-5(2013 Dec)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results present the first structures of AAK1 and BIKE which reveal that all members of the Numb-associated kinase family share unusual activation segment architecture.
Title: Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.

Two of these kinases that were classified as resistors were PX domain-containing serine/threonine kinase (PXK) and AP2-associated kinase 1 (AAK1), which promote receptor endocytosis and may enable cells to resist TRAIL-induced apoptosis
Title: Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.

AAK1 and GAK are critical regulators of HCV entry that function in part by activating EGFR, AP2M1, and NUMB, and as the molecular targets underlying the antiviral effect of sunitinib and erlotinib, respectively.
Title: AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.

AAK1 increases the localization of activated Notch to Rab5-positive endocytic vesicles, while AAK1 depletion or overexpression of Numb, an inhibitor of the pathway, interferes with this localization.
Title: The adaptor-associated kinase 1, AAK1, is a positive regulator of the Notch pathway.

Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

The following AAK1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AAK1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu25045	NM_014911.4 Latest version!	Homo sapiens AP2 associated kinase 1 (AAK1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
OHu109253	NM_001371575.1 Latest version!	Homo sapiens AP2 associated kinase 1 (AAK1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$475.30 $679.00
OHu109254	NM_001371577.1 Latest version!	Homo sapiens AP2 associated kinase 1 (AAK1), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$391.30 $559.00
View Old Accession Versions >>
OHu25045	NM_014911.3	Homo sapiens AP2 associated kinase 1 (AAK1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AAK1 ( NM_014911.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055726.3 Homo sapiens AP2 associated kinase 1 (AAK1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu25045
Clone ID Related Accession (Same CDS sequence)	NM_014911.4 , NM_014911.3
Accession Version	NM_014911.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2886bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	AP2-associated protein kinase 1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW451954.1, DB285703.1, BC111965.1, DA121999.1, AW969393.1, AC136007.3, AC114772.5 and CA436375.1. On Nov 22, 2018 this sequence version replaced NM_014911.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGAAGT TTTTCGACTC CCGGCGAGAG CAGGGCGGCT CTGGCCTGGG CTCCGGCTCC 
AGCGGAGGAG GGGGCAGCAC CTCGGGCCTG GGCAGTGGCT ACATCGGAAG AGTCTTCGGC 
ATCGGGCGAC AGCAGGTCAC AGTGGACGAG GTGTTGGCGG AAGGTGGATT TGCTATTGTA 
TTTCTGGTGA GGACAAGCAA TGGGATGAAA TGTGCCTTGA AACGCATGTT TGTCAACAAT 
GAGCATGATC TCCAGGTGTG CAAGAGAGAA ATCCAGATAA TGAGGGATCT TTCAGGGCAC 
AAGAATATTG TGGGTTACAT TGATTCTAGT ATCAACAACG TGAGTAGCGG TGATGTATGG 
GAAGTGCTCA TTCTGATGGA CTTTTGTAGA GGTGGCCAGG TGGTAAACCT GATGAACCAG 
CGCCTGCAAA CAGGCTTTAC AGAGAATGAA GTGCTCCAGA TATTTTGTGA TACCTGTGAA 
GCTGTTGCCC GCCTGCATCA GTGCAAAACT CCTATTATCC ACCGGGACCT GAAGGTTGAA 
AACATCCTCT TGCATGACCG AGGCCACTAT GTCCTGTGTG ACTTTGGAAG CGCCACCAAC 
AAATTCCAGA ATCCACAAAC TGAGGGAGTC AATGCAGTAG AAGATGAGAT TAAGAAATAC 
ACAACGCTGT CCTATCGAGC ACCAGAAATG GTCAACCTGT ACAGTGGCAA AATCATCACT 
ACGAAGGCAG ACATTTGGGC TCTTGGATGT TTGTTGTATA AATTATGCTA CTTCACTTTG 
CCATTTGGGG AAAGTCAGGT GGCAATTTGT GATGGAAACT TCACAATTCC TGATAATTCT 
CGATATTCTC AAGACATGCA CTGCCTAATT AGGTATATGT TGGAACCAGA CCCTGACAAA 
AGGCCGGATA TTTACCAGGT GTCCTACTTC TCATTTAAGC TACTCAAGAA AGAGTGCCCA 
ATTCCAAATG TACAGAACTC TCCCATTCCT GCAAAGCTTC CTGAACCAGT GAAAGCCAGT 
GAGGCAGCTG CAAAAAAGAC CCAGCCAAAG GCCAGACTGA CAGATCCCAT TCCCACCACA 
GAGACTTCAA TTGCACCCCG CCAGAGGCCT AAAGCTGGGC AGACTCAGCC GAACCCAGGA 
ATCCTTCCCA TCCAGCCAGC GCTGACACCC CGGAAGAGGG CCACTGTTCA GCCCCCACCT 
CAGGCTGCAG GATCCAGCAA TCAGCCTGGC CTTTTAGCCA GTGTTCCCCA ACCAAAACCC 
CAAGCCCCAC CCAGCCAGCC TCTGCCGCAA ACTCAGGCCA AGCAGCCACA GGCTCCTCCC 
ACTCCACAGC AGACGCCTTC TACTCAGGCC CAGGGTCTGC CCGCTCAGGC CCAGGCCACA 
CCCCAGCACC AGCAGCAACT CTTCCTCAAG CAGCAACAGC AGCAGCAACA GCCACCGCCA 
GCACAGCAGC AGCCGGCAGG CACGTTTTAC CAGCAGCAGC AGGCCCAGAC TCAGCAGTTT 
CAGGCAGTAC ATCCAGCAAC CCAGCAACCA GCAATTGCTC AGTTCCCTGT GGTGTCCCAA 
GGAGGCTCTC AACAGCAGCT AATGCAGAAT TTCTACCAGC AGCAGCAGCA GCAGCAACAA 
CAACAGCAAC AGCAACAGCT GGCCACAGCC CTGCATCAAC AACAGCTGAT GACTCAGCAG 
GCTGCCTTGC AGCAAAAGCC CACTATGGCA GCAGGACAGC AGCCCCAGCC ACAGCCAGCT 
GCAGCCCCAC AGCCAGCCCC TGCCCAGGAG CCAGCGATTC AAGCCCCAGT AAGACAACAG 
CCAAAGGTTC AGACAACCCC ACCTCCTGCC GTCCAGGGGC AGAAAGTTGG ATCTCTCACT 
CCACCCTCAT CCCCCAAAAC CCAACGTGCT GGGCACAGGC GTATTCTCAG TGACGTAACC 
CACAGTGCAG TCTTTGGGGT CCCTGCCAGC AAATCAACCC AGCTGCTCCA GGCAGCTGCA 
GCTGAGGCCA GTCTCAATAA GTCCAAGTCT GCAACCACCA CTCCATCAGG CTCTCCTCGG 
ACCTCTCAAC AAAACGTTTA TAATCCTTCA GAAGGGTCTA CGTGGAATCC CTTTGATGAC 
GATAATTTCT CCAAACTCAC AGCTGAAGAA CTGCTAAACA AGGACTTTGC CAAGCTTGGG 
GAAGGCAAAC ATCCCGAGAA GCTTGGAGGC TCAGCTGAGA GTTTGATCCC AGGCTTTCAA 
TCAACCCAAG GTGATGCTTT TGCTACGACC TCATTTTCTG CTGGAACTGC TGAAAAAAGG 
AAGGGTGGGC AGACTGTGGA CTCTGGCCTC CCGCTTCTAA GCGTGTCTGA TCCTTTCATT 
CCTCTTCAAG TACCTGATGC ACCAGAAAAA CTAATTGAGG GACTCAAATC TCCTGACACT 
TCTCTTCTGC TCCCTGACCT CTTGCCTATG ACAGATCCTT TTGGTAGCAC TTCTGATGCT 
GTAATTGAAA AAGCTGATGT TGCTGTTGAG AGTCTCATAC CAGGACTGGA GCCCCCAGTT 
CCCCAGCGCC TCCCATCTCA GACGGAATCT GTGACCTCGA ATCGCACAGA TTCTCTCACC 
GGGGAAGATT CCCTGCTTGA TTGCTCTCTG CTCTCTAACC CTACTACTGA CCTTCTGGAA 
GAGTTTGCCC CCACAGCAAT CTCTGCTCCA GTCCATAAAG CTGCAGAAGA TAGTAATCTC 
ATCTCAGGTT TTGATGTCCC TGAGGGCTCG GACAAGGTGG CTGAAGATGA GTTTGACCCT 
ATTCCTGTAT TGATAACCAA AAACCCACAA GGTGGGCACT CTAGAAACAG CAGTGGGAGC 
TCTGAGTCCA GTCTTCCCAA CCTAGCCAGG TCTTTACTGC TGGTGGATCA GCTCATAGAC 
CTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055726.3
CDS	400..3285
Translation	MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL

Target ORF information:

RefSeq Version	NM_014911.4
Organism	Homo sapiens(human)
Definition	Homo sapiens AP2 associated kinase 1 (AAK1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014911.4

ORF Insert Sequence:

ATGAAGAAGT TTTTCGACTC CCGGCGAGAG CAGGGCGGCT CTGGCCTGGG CTCCGGCTCC 
AGCGGAGGAG GGGGCAGCAC CTCGGGCCTG GGCAGTGGCT ACATCGGAAG AGTCTTCGGC 
ATCGGGCGAC AGCAGGTCAC AGTGGACGAG GTGTTGGCGG AAGGTGGATT TGCTATTGTA 
TTTCTGGTGA GGACAAGCAA TGGGATGAAA TGTGCCTTGA AACGCATGTT TGTCAACAAT 
GAGCATGATC TCCAGGTGTG CAAGAGAGAA ATCCAGATAA TGAGGGATCT TTCAGGGCAC 
AAGAATATTG TGGGTTACAT TGATTCTAGT ATCAACAACG TGAGTAGCGG TGATGTATGG 
GAAGTGCTCA TTCTGATGGA CTTTTGTAGA GGTGGCCAGG TGGTAAACCT GATGAACCAG 
CGCCTGCAAA CAGGCTTTAC AGAGAATGAA GTGCTCCAGA TATTTTGTGA TACCTGTGAA 
GCTGTTGCCC GCCTGCATCA GTGCAAAACT CCTATTATCC ACCGGGACCT GAAGGTTGAA 
AACATCCTCT TGCATGACCG AGGCCACTAT GTCCTGTGTG ACTTTGGAAG CGCCACCAAC 
AAATTCCAGA ATCCACAAAC TGAGGGAGTC AATGCAGTAG AAGATGAGAT TAAGAAATAC 
ACAACGCTGT CCTATCGAGC ACCAGAAATG GTCAACCTGT ACAGTGGCAA AATCATCACT 
ACGAAGGCAG ACATTTGGGC TCTTGGATGT TTGTTGTATA AATTATGCTA CTTCACTTTG 
CCATTTGGGG AAAGTCAGGT GGCAATTTGT GATGGAAACT TCACAATTCC TGATAATTCT 
CGATATTCTC AAGACATGCA CTGCCTAATT AGGTATATGT TGGAACCAGA CCCTGACAAA 
AGGCCGGATA TTTACCAGGT GTCCTACTTC TCATTTAAGC TACTCAAGAA AGAGTGCCCA 
ATTCCAAATG TACAGAACTC TCCCATTCCT GCAAAGCTTC CTGAACCAGT GAAAGCCAGT 
GAGGCAGCTG CAAAAAAGAC CCAGCCAAAG GCCAGACTGA CAGATCCCAT TCCCACCACA 
GAGACTTCAA TTGCACCCCG CCAGAGGCCT AAAGCTGGGC AGACTCAGCC GAACCCAGGA 
ATCCTTCCCA TCCAGCCAGC GCTGACACCC CGGAAGAGGG CCACTGTTCA GCCCCCACCT 
CAGGCTGCAG GATCCAGCAA TCAGCCTGGC CTTTTAGCCA GTGTTCCCCA ACCAAAACCC 
CAAGCCCCAC CCAGCCAGCC TCTGCCGCAA ACTCAGGCCA AGCAGCCACA GGCTCCTCCC 
ACTCCACAGC AGACGCCTTC TACTCAGGCC CAGGGTCTGC CCGCTCAGGC CCAGGCCACA 
CCCCAGCACC AGCAGCAACT CTTCCTCAAG CAGCAACAGC AGCAGCAACA GCCACCGCCA 
GCACAGCAGC AGCCGGCAGG CACGTTTTAC CAGCAGCAGC AGGCCCAGAC TCAGCAGTTT 
CAGGCAGTAC ATCCAGCAAC CCAGCAACCA GCAATTGCTC AGTTCCCTGT GGTGTCCCAA 
GGAGGCTCTC AACAGCAGCT AATGCAGAAT TTCTACCAGC AGCAGCAGCA GCAGCAACAA 
CAACAGCAAC AGCAACAGCT GGCCACAGCC CTGCATCAAC AACAGCTGAT GACTCAGCAG 
GCTGCCTTGC AGCAAAAGCC CACTATGGCA GCAGGACAGC AGCCCCAGCC ACAGCCAGCT 
GCAGCCCCAC AGCCAGCCCC TGCCCAGGAG CCAGCGATTC AAGCCCCAGT AAGACAACAG 
CCAAAGGTTC AGACAACCCC ACCTCCTGCC GTCCAGGGGC AGAAAGTTGG ATCTCTCACT 
CCACCCTCAT CCCCCAAAAC CCAACGTGCT GGGCACAGGC GTATTCTCAG TGACGTAACC 
CACAGTGCAG TCTTTGGGGT CCCTGCCAGC AAATCAACCC AGCTGCTCCA GGCAGCTGCA 
GCTGAGGCCA GTCTCAATAA GTCCAAGTCT GCAACCACCA CTCCATCAGG CTCTCCTCGG 
ACCTCTCAAC AAAACGTTTA TAATCCTTCA GAAGGGTCTA CGTGGAATCC CTTTGATGAC 
GATAATTTCT CCAAACTCAC AGCTGAAGAA CTGCTAAACA AGGACTTTGC CAAGCTTGGG 
GAAGGCAAAC ATCCCGAGAA GCTTGGAGGC TCAGCTGAGA GTTTGATCCC AGGCTTTCAA 
TCAACCCAAG GTGATGCTTT TGCTACGACC TCATTTTCTG CTGGAACTGC TGAAAAAAGG 
AAGGGTGGGC AGACTGTGGA CTCTGGCCTC CCGCTTCTAA GCGTGTCTGA TCCTTTCATT 
CCTCTTCAAG TACCTGATGC ACCAGAAAAA CTAATTGAGG GACTCAAATC TCCTGACACT 
TCTCTTCTGC TCCCTGACCT CTTGCCTATG ACAGATCCTT TTGGTAGCAC TTCTGATGCT 
GTAATTGAAA AAGCTGATGT TGCTGTTGAG AGTCTCATAC CAGGACTGGA GCCCCCAGTT 
CCCCAGCGCC TCCCATCTCA GACGGAATCT GTGACCTCGA ATCGCACAGA TTCTCTCACC 
GGGGAAGATT CCCTGCTTGA TTGCTCTCTG CTCTCTAACC CTACTACTGA CCTTCTGGAA 
GAGTTTGCCC CCACAGCAAT CTCTGCTCCA GTCCATAAAG CTGCAGAAGA TAGTAATCTC 
ATCTCAGGTT TTGATGTCCC TGAGGGCTCG GACAAGGTGG CTGAAGATGA GTTTGACCCT 
ATTCCTGTAT TGATAACCAA AAACCCACAA GGTGGGCACT CTAGAAACAG CAGTGGGAGC 
TCTGAGTCCA GTCTTCCCAA CCTAGCCAGG TCTTTACTGC TGGTGGATCA GCTCATAGAC 
CTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AAK1 ( NM_014911.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055726.3 Homo sapiens AP2 associated kinase 1 (AAK1), mRNA.

Price & Availability↑

CloneID	OHu25045
Clone ID Related Accession (Same CDS sequence)	NM_014911.4 , NM_014911.3
Accession Version	NM_014911.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2886bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	AP2-associated protein kinase 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AW451954.1, DB285703.1, BC111965.1, DA121999.1, AW969393.1, AC136007.3, AC114772.5 and CA436375.1. On or before May 25, 2007 this sequence version replaced XM_930257.2, XM_941900.2, NM_014911.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGAAGT TTTTCGACTC CCGGCGAGAG CAGGGCGGCT CTGGCCTGGG CTCCGGCTCC 
AGCGGAGGAG GGGGCAGCAC CTCGGGCCTG GGCAGTGGCT ACATCGGAAG AGTCTTCGGC 
ATCGGGCGAC AGCAGGTCAC AGTGGACGAG GTGTTGGCGG AAGGTGGATT TGCTATTGTA 
TTTCTGGTGA GGACAAGCAA TGGGATGAAA TGTGCCTTGA AACGCATGTT TGTCAACAAT 
GAGCATGATC TCCAGGTGTG CAAGAGAGAA ATCCAGATAA TGAGGGATCT TTCAGGGCAC 
AAGAATATTG TGGGTTACAT TGATTCTAGT ATCAACAACG TGAGTAGCGG TGATGTATGG 
GAAGTGCTCA TTCTGATGGA CTTTTGTAGA GGTGGCCAGG TGGTAAACCT GATGAACCAG 
CGCCTGCAAA CAGGCTTTAC AGAGAATGAA GTGCTCCAGA TATTTTGTGA TACCTGTGAA 
GCTGTTGCCC GCCTGCATCA GTGCAAAACT CCTATTATCC ACCGGGACCT GAAGGTTGAA 
AACATCCTCT TGCATGACCG AGGCCACTAT GTCCTGTGTG ACTTTGGAAG CGCCACCAAC 
AAATTCCAGA ATCCACAAAC TGAGGGAGTC AATGCAGTAG AAGATGAGAT TAAGAAATAC 
ACAACGCTGT CCTATCGAGC ACCAGAAATG GTCAACCTGT ACAGTGGCAA AATCATCACT 
ACGAAGGCAG ACATTTGGGC TCTTGGATGT TTGTTGTATA AATTATGCTA CTTCACTTTG 
CCATTTGGGG AAAGTCAGGT GGCAATTTGT GATGGAAACT TCACAATTCC TGATAATTCT 
CGATATTCTC AAGACATGCA CTGCCTAATT AGGTATATGT TGGAACCAGA CCCTGACAAA 
AGGCCGGATA TTTACCAGGT GTCCTACTTC TCATTTAAGC TACTCAAGAA AGAGTGCCCA 
ATTCCAAATG TACAGAACTC TCCCATTCCT GCAAAGCTTC CTGAACCAGT GAAAGCCAGT 
GAGGCAGCTG CAAAAAAGAC CCAGCCAAAG GCCAGACTGA CAGATCCCAT TCCCACCACA 
GAGACTTCAA TTGCACCCCG CCAGAGGCCT AAAGCTGGGC AGACTCAGCC GAACCCAGGA 
ATCCTTCCCA TCCAGCCAGC GCTGACACCC CGGAAGAGGG CCACTGTTCA GCCCCCACCT 
CAGGCTGCAG GATCCAGCAA TCAGCCTGGC CTTTTAGCCA GTGTTCCCCA ACCAAAACCC 
CAAGCCCCAC CCAGCCAGCC TCTGCCGCAA ACTCAGGCCA AGCAGCCACA GGCTCCTCCC 
ACTCCACAGC AGACGCCTTC TACTCAGGCC CAGGGTCTGC CCGCTCAGGC CCAGGCCACA 
CCCCAGCACC AGCAGCAACT CTTCCTCAAG CAGCAACAGC AGCAGCAACA GCCACCGCCA 
GCACAGCAGC AGCCGGCAGG CACGTTTTAC CAGCAGCAGC AGGCCCAGAC TCAGCAGTTT 
CAGGCAGTAC ATCCAGCAAC CCAGCAACCA GCAATTGCTC AGTTCCCTGT GGTGTCCCAA 
GGAGGCTCTC AACAGCAGCT AATGCAGAAT TTCTACCAGC AGCAGCAGCA GCAGCAACAA 
CAACAGCAAC AGCAACAGCT GGCCACAGCC CTGCATCAAC AACAGCTGAT GACTCAGCAG 
GCTGCCTTGC AGCAAAAGCC CACTATGGCA GCAGGACAGC AGCCCCAGCC ACAGCCAGCT 
GCAGCCCCAC AGCCAGCCCC TGCCCAGGAG CCAGCGATTC AAGCCCCAGT AAGACAACAG 
CCAAAGGTTC AGACAACCCC ACCTCCTGCC GTCCAGGGGC AGAAAGTTGG ATCTCTCACT 
CCACCCTCAT CCCCCAAAAC CCAACGTGCT GGGCACAGGC GTATTCTCAG TGACGTAACC 
CACAGTGCAG TCTTTGGGGT CCCTGCCAGC AAATCAACCC AGCTGCTCCA GGCAGCTGCA 
GCTGAGGCCA GTCTCAATAA GTCCAAGTCT GCAACCACCA CTCCATCAGG CTCTCCTCGG 
ACCTCTCAAC AAAACGTTTA TAATCCTTCA GAAGGGTCTA CGTGGAATCC CTTTGATGAC 
GATAATTTCT CCAAACTCAC AGCTGAAGAA CTGCTAAACA AGGACTTTGC CAAGCTTGGG 
GAAGGCAAAC ATCCCGAGAA GCTTGGAGGC TCAGCTGAGA GTTTGATCCC AGGCTTTCAA 
TCAACCCAAG GTGATGCTTT TGCTACGACC TCATTTTCTG CTGGAACTGC TGAAAAAAGG 
AAGGGTGGGC AGACTGTGGA CTCTGGCCTC CCGCTTCTAA GCGTGTCTGA TCCTTTCATT 
CCTCTTCAAG TACCTGATGC ACCAGAAAAA CTAATTGAGG GACTCAAATC TCCTGACACT 
TCTCTTCTGC TCCCTGACCT CTTGCCTATG ACAGATCCTT TTGGTAGCAC TTCTGATGCT 
GTAATTGAAA AAGCTGATGT TGCTGTTGAG AGTCTCATAC CAGGACTGGA GCCCCCAGTT 
CCCCAGCGCC TCCCATCTCA GACGGAATCT GTGACCTCGA ATCGCACAGA TTCTCTCACC 
GGGGAAGATT CCCTGCTTGA TTGCTCTCTG CTCTCTAACC CTACTACTGA CCTTCTGGAA 
GAGTTTGCCC CCACAGCAAT CTCTGCTCCA GTCCATAAAG CTGCAGAAGA TAGTAATCTC 
ATCTCAGGTT TTGATGTCCC TGAGGGCTCG GACAAGGTGG CTGAAGATGA GTTTGACCCT 
ATTCCTGTAT TGATAACCAA AAACCCACAA GGTGGGCACT CTAGAAACAG CAGTGGGAGC 
TCTGAGTCCA GTCTTCCCAA CCTAGCCAGG TCTTTACTGC TGGTGGATCA GCTCATAGAC 
CTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055726.3
CDS	506..3391
Translation	MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQQPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTTDLLEEFAPTAISAPVHKAAEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL

Target ORF information:

RefSeq Version	NM_014911.3
Organism	Homo sapiens(human)
Definition	Homo sapiens AP2 associated kinase 1 (AAK1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014911.3

ORF Insert Sequence:

ATGAAGAAGT TTTTCGACTC CCGGCGAGAG CAGGGCGGCT CTGGCCTGGG CTCCGGCTCC 
AGCGGAGGAG GGGGCAGCAC CTCGGGCCTG GGCAGTGGCT ACATCGGAAG AGTCTTCGGC 
ATCGGGCGAC AGCAGGTCAC AGTGGACGAG GTGTTGGCGG AAGGTGGATT TGCTATTGTA 
TTTCTGGTGA GGACAAGCAA TGGGATGAAA TGTGCCTTGA AACGCATGTT TGTCAACAAT 
GAGCATGATC TCCAGGTGTG CAAGAGAGAA ATCCAGATAA TGAGGGATCT TTCAGGGCAC 
AAGAATATTG TGGGTTACAT TGATTCTAGT ATCAACAACG TGAGTAGCGG TGATGTATGG 
GAAGTGCTCA TTCTGATGGA CTTTTGTAGA GGTGGCCAGG TGGTAAACCT GATGAACCAG 
CGCCTGCAAA CAGGCTTTAC AGAGAATGAA GTGCTCCAGA TATTTTGTGA TACCTGTGAA 
GCTGTTGCCC GCCTGCATCA GTGCAAAACT CCTATTATCC ACCGGGACCT GAAGGTTGAA 
AACATCCTCT TGCATGACCG AGGCCACTAT GTCCTGTGTG ACTTTGGAAG CGCCACCAAC 
AAATTCCAGA ATCCACAAAC TGAGGGAGTC AATGCAGTAG AAGATGAGAT TAAGAAATAC 
ACAACGCTGT CCTATCGAGC ACCAGAAATG GTCAACCTGT ACAGTGGCAA AATCATCACT 
ACGAAGGCAG ACATTTGGGC TCTTGGATGT TTGTTGTATA AATTATGCTA CTTCACTTTG 
CCATTTGGGG AAAGTCAGGT GGCAATTTGT GATGGAAACT TCACAATTCC TGATAATTCT 
CGATATTCTC AAGACATGCA CTGCCTAATT AGGTATATGT TGGAACCAGA CCCTGACAAA 
AGGCCGGATA TTTACCAGGT GTCCTACTTC TCATTTAAGC TACTCAAGAA AGAGTGCCCA 
ATTCCAAATG TACAGAACTC TCCCATTCCT GCAAAGCTTC CTGAACCAGT GAAAGCCAGT 
GAGGCAGCTG CAAAAAAGAC CCAGCCAAAG GCCAGACTGA CAGATCCCAT TCCCACCACA 
GAGACTTCAA TTGCACCCCG CCAGAGGCCT AAAGCTGGGC AGACTCAGCC GAACCCAGGA 
ATCCTTCCCA TCCAGCCAGC GCTGACACCC CGGAAGAGGG CCACTGTTCA GCCCCCACCT 
CAGGCTGCAG GATCCAGCAA TCAGCCTGGC CTTTTAGCCA GTGTTCCCCA ACCAAAACCC 
CAAGCCCCAC CCAGCCAGCC TCTGCCGCAA ACTCAGGCCA AGCAGCCACA GGCTCCTCCC 
ACTCCACAGC AGACGCCTTC TACTCAGGCC CAGGGTCTGC CCGCTCAGGC CCAGGCCACA 
CCCCAGCACC AGCAGCAACT CTTCCTCAAG CAGCAACAGC AGCAGCAACA GCCACCGCCA 
GCACAGCAGC AGCCGGCAGG CACGTTTTAC CAGCAGCAGC AGGCCCAGAC TCAGCAGTTT 
CAGGCAGTAC ATCCAGCAAC CCAGCAACCA GCAATTGCTC AGTTCCCTGT GGTGTCCCAA 
GGAGGCTCTC AACAGCAGCT AATGCAGAAT TTCTACCAGC AGCAGCAGCA GCAGCAACAA 
CAACAGCAAC AGCAACAGCT GGCCACAGCC CTGCATCAAC AACAGCTGAT GACTCAGCAG 
GCTGCCTTGC AGCAAAAGCC CACTATGGCA GCAGGACAGC AGCCCCAGCC ACAGCCAGCT 
GCAGCCCCAC AGCCAGCCCC TGCCCAGGAG CCAGCGATTC AAGCCCCAGT AAGACAACAG 
CCAAAGGTTC AGACAACCCC ACCTCCTGCC GTCCAGGGGC AGAAAGTTGG ATCTCTCACT 
CCACCCTCAT CCCCCAAAAC CCAACGTGCT GGGCACAGGC GTATTCTCAG TGACGTAACC 
CACAGTGCAG TCTTTGGGGT CCCTGCCAGC AAATCAACCC AGCTGCTCCA GGCAGCTGCA 
GCTGAGGCCA GTCTCAATAA GTCCAAGTCT GCAACCACCA CTCCATCAGG CTCTCCTCGG 
ACCTCTCAAC AAAACGTTTA TAATCCTTCA GAAGGGTCTA CGTGGAATCC CTTTGATGAC 
GATAATTTCT CCAAACTCAC AGCTGAAGAA CTGCTAAACA AGGACTTTGC CAAGCTTGGG 
GAAGGCAAAC ATCCCGAGAA GCTTGGAGGC TCAGCTGAGA GTTTGATCCC AGGCTTTCAA 
TCAACCCAAG GTGATGCTTT TGCTACGACC TCATTTTCTG CTGGAACTGC TGAAAAAAGG 
AAGGGTGGGC AGACTGTGGA CTCTGGCCTC CCGCTTCTAA GCGTGTCTGA TCCTTTCATT 
CCTCTTCAAG TACCTGATGC ACCAGAAAAA CTAATTGAGG GACTCAAATC TCCTGACACT 
TCTCTTCTGC TCCCTGACCT CTTGCCTATG ACAGATCCTT TTGGTAGCAC TTCTGATGCT 
GTAATTGAAA AAGCTGATGT TGCTGTTGAG AGTCTCATAC CAGGACTGGA GCCCCCAGTT 
CCCCAGCGCC TCCCATCTCA GACGGAATCT GTGACCTCGA ATCGCACAGA TTCTCTCACC 
GGGGAAGATT CCCTGCTTGA TTGCTCTCTG CTCTCTAACC CTACTACTGA CCTTCTGGAA 
GAGTTTGCCC CCACAGCAAT CTCTGCTCCA GTCCATAAAG CTGCAGAAGA TAGTAATCTC 
ATCTCAGGTT TTGATGTCCC TGAGGGCTCG GACAAGGTGG CTGAAGATGA GTTTGACCCT 
ATTCCTGTAT TGATAACCAA AAACCCACAA GGTGGGCACT CTAGAAACAG CAGTGGGAGC 
TCTGAGTCCA GTCTTCCCAA CCTAGCCAGG TCTTTACTGC TGGTGGATCA GCTCATAGAC 
CTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AAK1 ( NM_001371575.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001358504.1 Homo sapiens AP2 associated kinase 1 (AAK1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu109253
Clone ID Related Accession (Same CDS sequence)	NM_001371575.1
Accession Version	NM_001371575.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2769bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	AP2-associated protein kinase 1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092431.7, AC079121.5, AC136007.3 and AC114772.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138518.320537.1 [ECO:0000332] ##Evidence-Data-END##

ATGAAGAAGT TTTTCGACTC CCGGCGAGAG CAGGGCGGCT CTGGCCTGGG CTCCGGCTCC 
AGCGGAGGAG GGGGCAGCAC CTCGGGCCTG GGCAGTGGCT ACATCGGAAG AGTCTTCGGC 
ATCGGGCGAC AGCAGGTCAC AGTGGACGAG GTGTTGGCGG AAGGTGGATT TGCTATTGTA 
TTTCTGGTGA GGACAAGCAA TGGGATGAAA TGTGCCTTGA AACGCATGTT TGTCAACAAT 
GAGCATGATC TCCAGGTGTG CAAGAGAGAA ATCCAGATAA TGAGGGATCT TTCAGGGCAC 
AAGAATATTG TGGGTTACAT TGATTCTAGT ATCAACAACG TGAGTAGCGG TGATGTATGG 
GAAGTGCTCA TTCTGATGGA CTTTTGTAGA GGTGGCCAGG TGGTAAACCT GATGAACCAG 
CGCCTGCAAA CAGGCTTTAC AGAGAATGAA GTGCTCCAGA TATTTTGTGA TACCTGTGAA 
GCTGTTGCCC GCCTGCATCA GTGCAAAACT CCTATTATCC ACCGGGACCT GAAGGTTGAA 
AACATCCTCT TGCATGACCG AGGCCACTAT GTCCTGTGTG ACTTTGGAAG CGCCACCAAC 
AAATTCCAGA ATCCACAAAC TGAGGGAGTC AATGCAGTAG AAGATGAGAT TAAGAAATAC 
ACAACGCTGT CCTATCGAGC ACCAGAAATG GTCAACCTGT ACAGTGGCAA AATCATCACT 
ACGAAGGCAG ACATTTGGGC TCTTGGATGT TTGTTGTATA AATTATGCTA CTTCACTTTG 
CCATTTGGGG AAAGTCAGGT GGCAATTTGT GATGGAAACT TCACAATTCC TGATAATTCT 
CGATATTCTC AAGACATGCA CTGCCTAATT AGGTATATGT TGGAACCAGA CCCTGACAAA 
AGGCCGGATA TTTACCAGGT GTCCTACTTC TCATTTAAGC TACTCAAGAA AGAGTGCCCA 
ATTCCAAATG TACAGAACTC TCCCATTCCT GCAAAGCTTC CTGAACCAGT GAAAGCCAGT 
GAGGCAGCTG CAAAAAAGAC CCAGCCAAAG GCCAGACTGA CAGATCCCAT TCCCACCACA 
GAGACTTCAA TTGCACCCCG CCAGAGGCCT AAAGCTGGGC AGACTCAGCC GAACCCAGGA 
ATCCTTCCCA TCCAGCCAGC GCTGACACCC CGGAAGAGGG CCACTGTTCA GCCCCCACCT 
CAGGCTGCAG GATCCAGCAA TCAGCCTGGC CTTTTAGCCA GTGTTCCCCA ACCAAAACCC 
CAAGCCCCAC CCAGCCAGCC TCTGCCGCAA ACTCAGGCCA AGCAGCCACA GGCTCCTCCC 
ACTCCACAGC AGACGCCTTC TACTCAGGCC CAGGGTCTGC CCGCTCAGGC CCAGGCCACA 
CCCCAGCACC AGCAGCAACT CTTCCTCAAG CAGCAACAGC AGCAGCAACA GCCACCGCCA 
GCACAGCAGC AGCCGGCAGG CACGTTTTAC CAGCAGCAGC AGGCCCAGAC TCAGCAGTTT 
CAGGCAGTAC ATCCAGCAAC CCAGAAACCA GCAATTGCTC AGTTCCCTGT GGTGTCCCAA 
GGAGGCTCTC AACAGCAGCT AATGCAGAAT TTCTACCAGC AGCAGCAGCA GCAGCAACAA 
CAACAGCAAC AGCAACAGCT GGCCACAGCC CTGCATCAAC AACAGCTGAT GACTCAGCAG 
GCTGCCTTGC AGCAAAAGCC CACTATGGCA GCAGGACAGC AGCCCCAGCC ACAGCCAGCT 
GCAGCCCCAC AGCCAGCCCC TGCCCAGGAG CCAGCGATTC AAGCCCCAGT AAGACAACAG 
CCAAAGGTTC AGACAACCCC ACCTCCTGCC GTCCAGGGGC AGAAAGTTGG ATCTCTCACT 
CCACCCTCAT CCCCCAAAAC CCAACGTGCT GGGCACAGGC GTATTCTCAG TGACGTAACC 
CACAGTGCAG TCTTTGGGGT CCCTGCCAGC AAATCAACCC AGCTGCTCCA GGCAGCTGCA 
GCTGAGGCCA GTCTCAATAA GTCCAAGTCT GCAACCACCA CTCCATCAGG CTCTCCTCGG 
ACCTCTCAAC AAAACGTTTA TAATCCTTCA GAAGGGTCTA CGTGGAATCC CTTTGATGAC 
GATAATTTCT CCAAACTCAC AGCTGAAGAA CTGCTAAACA AGGACTTTGC CAAGCTTGGG 
GAAGGCAAAC ATCCCGAGAA GCTTGGAGGC TCAGCTGAGA GTTTGATCCC AGGCTTTCAA 
TCAACCCAAG GTGATGCTTT TGCTACGACC TCATTTTCTG CTGGAACTGC TGAAAAAAGG 
AAGGGTGGGC AGACTGTGGA CTCTGGCCTC CCGCTTCTAA GCGTGTCTGA TCCTTTCATT 
CCTCTTCAAG TACCTGATGC ACCAGAAAAA CTAATTGAGG GACTCAAATC TCCTGACACT 
TCTCTTCTGC TCCCTGACCT CTTGCCTATG ACAGATCCTT TTGGTAGCAC TTCTGATGCT 
GTAATTGAAA AAGCTGATGT TGCTGTTGAG AGTCTCATAC CAGGACTGGA GCCCCCAGTT 
CCCCAGCGCC TCCCATCTCA GACGGAATCT GTGACCTCGA ATCGCACAGA AGATAGTAAT 
CTCATCTCAG GTTTTGATGT CCCTGAGGGC TCGGACAAGG TGGCTGAAGA TGAGTTTGAC 
CCTATTCCTG TATTGATAAC CAAAAACCCA CAAGGTGGGC ACTCTAGAAA CAGCAGTGGG 
AGCTCTGAGT CCAGTCTTCC CAACCTAGCC AGGTCTTTAC TGCTGGTGGA TCAGCTCATA 
GACCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001358504.1
CDS	399..3167
Translation	MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSEGSTWNPFDDDNFSKLTAEELLNKDFAKLGEGKHPEKLGGSAESLIPGFQSTQGDAFATTSFSAGTAEKRKGGQTVDSGLPLLSVSDPFIPLQVPDAPEKLIEGLKSPDTSLLLPDLLPMTDPFGSTSDAVIEKADVAVESLIPGLEPPVPQRLPSQTESVTSNRTEDSNLISGFDVPEGSDKVAEDEFDPIPVLITKNPQGGHSRNSSGSSESSLPNLARSLLLVDQLIDL

Target ORF information:

RefSeq Version	NM_001371575.1
Organism	Homo sapiens(human)
Definition	Homo sapiens AP2 associated kinase 1 (AAK1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001371575.1

ORF Insert Sequence:

ATGAAGAAGT TTTTCGACTC CCGGCGAGAG CAGGGCGGCT CTGGCCTGGG CTCCGGCTCC 
AGCGGAGGAG GGGGCAGCAC CTCGGGCCTG GGCAGTGGCT ACATCGGAAG AGTCTTCGGC 
ATCGGGCGAC AGCAGGTCAC AGTGGACGAG GTGTTGGCGG AAGGTGGATT TGCTATTGTA 
TTTCTGGTGA GGACAAGCAA TGGGATGAAA TGTGCCTTGA AACGCATGTT TGTCAACAAT 
GAGCATGATC TCCAGGTGTG CAAGAGAGAA ATCCAGATAA TGAGGGATCT TTCAGGGCAC 
AAGAATATTG TGGGTTACAT TGATTCTAGT ATCAACAACG TGAGTAGCGG TGATGTATGG 
GAAGTGCTCA TTCTGATGGA CTTTTGTAGA GGTGGCCAGG TGGTAAACCT GATGAACCAG 
CGCCTGCAAA CAGGCTTTAC AGAGAATGAA GTGCTCCAGA TATTTTGTGA TACCTGTGAA 
GCTGTTGCCC GCCTGCATCA GTGCAAAACT CCTATTATCC ACCGGGACCT GAAGGTTGAA 
AACATCCTCT TGCATGACCG AGGCCACTAT GTCCTGTGTG ACTTTGGAAG CGCCACCAAC 
AAATTCCAGA ATCCACAAAC TGAGGGAGTC AATGCAGTAG AAGATGAGAT TAAGAAATAC 
ACAACGCTGT CCTATCGAGC ACCAGAAATG GTCAACCTGT ACAGTGGCAA AATCATCACT 
ACGAAGGCAG ACATTTGGGC TCTTGGATGT TTGTTGTATA AATTATGCTA CTTCACTTTG 
CCATTTGGGG AAAGTCAGGT GGCAATTTGT GATGGAAACT TCACAATTCC TGATAATTCT 
CGATATTCTC AAGACATGCA CTGCCTAATT AGGTATATGT TGGAACCAGA CCCTGACAAA 
AGGCCGGATA TTTACCAGGT GTCCTACTTC TCATTTAAGC TACTCAAGAA AGAGTGCCCA 
ATTCCAAATG TACAGAACTC TCCCATTCCT GCAAAGCTTC CTGAACCAGT GAAAGCCAGT 
GAGGCAGCTG CAAAAAAGAC CCAGCCAAAG GCCAGACTGA CAGATCCCAT TCCCACCACA 
GAGACTTCAA TTGCACCCCG CCAGAGGCCT AAAGCTGGGC AGACTCAGCC GAACCCAGGA 
ATCCTTCCCA TCCAGCCAGC GCTGACACCC CGGAAGAGGG CCACTGTTCA GCCCCCACCT 
CAGGCTGCAG GATCCAGCAA TCAGCCTGGC CTTTTAGCCA GTGTTCCCCA ACCAAAACCC 
CAAGCCCCAC CCAGCCAGCC TCTGCCGCAA ACTCAGGCCA AGCAGCCACA GGCTCCTCCC 
ACTCCACAGC AGACGCCTTC TACTCAGGCC CAGGGTCTGC CCGCTCAGGC CCAGGCCACA 
CCCCAGCACC AGCAGCAACT CTTCCTCAAG CAGCAACAGC AGCAGCAACA GCCACCGCCA 
GCACAGCAGC AGCCGGCAGG CACGTTTTAC CAGCAGCAGC AGGCCCAGAC TCAGCAGTTT 
CAGGCAGTAC ATCCAGCAAC CCAGAAACCA GCAATTGCTC AGTTCCCTGT GGTGTCCCAA 
GGAGGCTCTC AACAGCAGCT AATGCAGAAT TTCTACCAGC AGCAGCAGCA GCAGCAACAA 
CAACAGCAAC AGCAACAGCT GGCCACAGCC CTGCATCAAC AACAGCTGAT GACTCAGCAG 
GCTGCCTTGC AGCAAAAGCC CACTATGGCA GCAGGACAGC AGCCCCAGCC ACAGCCAGCT 
GCAGCCCCAC AGCCAGCCCC TGCCCAGGAG CCAGCGATTC AAGCCCCAGT AAGACAACAG 
CCAAAGGTTC AGACAACCCC ACCTCCTGCC GTCCAGGGGC AGAAAGTTGG ATCTCTCACT 
CCACCCTCAT CCCCCAAAAC CCAACGTGCT GGGCACAGGC GTATTCTCAG TGACGTAACC 
CACAGTGCAG TCTTTGGGGT CCCTGCCAGC AAATCAACCC AGCTGCTCCA GGCAGCTGCA 
GCTGAGGCCA GTCTCAATAA GTCCAAGTCT GCAACCACCA CTCCATCAGG CTCTCCTCGG 
ACCTCTCAAC AAAACGTTTA TAATCCTTCA GAAGGGTCTA CGTGGAATCC CTTTGATGAC 
GATAATTTCT CCAAACTCAC AGCTGAAGAA CTGCTAAACA AGGACTTTGC CAAGCTTGGG 
GAAGGCAAAC ATCCCGAGAA GCTTGGAGGC TCAGCTGAGA GTTTGATCCC AGGCTTTCAA 
TCAACCCAAG GTGATGCTTT TGCTACGACC TCATTTTCTG CTGGAACTGC TGAAAAAAGG 
AAGGGTGGGC AGACTGTGGA CTCTGGCCTC CCGCTTCTAA GCGTGTCTGA TCCTTTCATT 
CCTCTTCAAG TACCTGATGC ACCAGAAAAA CTAATTGAGG GACTCAAATC TCCTGACACT 
TCTCTTCTGC TCCCTGACCT CTTGCCTATG ACAGATCCTT TTGGTAGCAC TTCTGATGCT 
GTAATTGAAA AAGCTGATGT TGCTGTTGAG AGTCTCATAC CAGGACTGGA GCCCCCAGTT 
CCCCAGCGCC TCCCATCTCA GACGGAATCT GTGACCTCGA ATCGCACAGA AGATAGTAAT 
CTCATCTCAG GTTTTGATGT CCCTGAGGGC TCGGACAAGG TGGCTGAAGA TGAGTTTGAC 
CCTATTCCTG TATTGATAAC CAAAAACCCA CAAGGTGGGC ACTCTAGAAA CAGCAGTGGG 
AGCTCTGAGT CCAGTCTTCC CAACCTAGCC AGGTCTTTAC TGCTGGTGGA TCAGCTCATA 
GACCTGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AAK1 ( NM_001371577.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001358506.1 Homo sapiens AP2 associated kinase 1 (AAK1), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu109254
Clone ID Related Accession (Same CDS sequence)	NM_001371577.1
Accession Version	NM_001371577.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2025bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-19
Organism	Homo sapiens(human)
Product	AP2-associated protein kinase 1 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC092431.7, AC079121.5 and AC114772.5. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK056043.1 [ECO:0000332] ##Evidence-Data-END##

ATGAAGAAGT TTTTCGACTC CCGGCGAGAG CAGGGCGGCT CTGGCCTGGG CTCCGGCTCC 
AGCGGAGGAG GGGGCAGCAC CTCGGGCCTG GGCAGTGGCT ACATCGGAAG AGTCTTCGGC 
ATCGGGCGAC AGCAGGTCAC AGTGGACGAG GTGTTGGCGG AAGGTGGATT TGCTATTGTA 
TTTCTGGTGA GGACAAGCAA TGGGATGAAA TGTGCCTTGA AACGCATGTT TGTCAACAAT 
GAGCATGATC TCCAGGTGTG CAAGAGAGAA ATCCAGATAA TGAGGGATCT TTCAGGGCAC 
AAGAATATTG TGGGTTACAT TGATTCTAGT ATCAACAACG TGAGTAGCGG TGATGTATGG 
GAAGTGCTCA TTCTGATGGA CTTTTGTAGA GGTGGCCAGG TGGTAAACCT GATGAACCAG 
CGCCTGCAAA CAGGCTTTAC AGAGAATGAA GTGCTCCAGA TATTTTGTGA TACCTGTGAA 
GCTGTTGCCC GCCTGCATCA GTGCAAAACT CCTATTATCC ACCGGGACCT GAAGGTTGAA 
AACATCCTCT TGCATGACCG AGGCCACTAT GTCCTGTGTG ACTTTGGAAG CGCCACCAAC 
AAATTCCAGA ATCCACAAAC TGAGGGAGTC AATGCAGTAG AAGATGAGAT TAAGAAATAC 
ACAACGCTGT CCTATCGAGC ACCAGAAATG GTCAACCTGT ACAGTGGCAA AATCATCACT 
ACGAAGGCAG ACATTTGGGC TCTTGGATGT TTGTTGTATA AATTATGCTA CTTCACTTTG 
CCATTTGGGG AAAGTCAGGT GGCAATTTGT GATGGAAACT TCACAATTCC TGATAATTCT 
CGATATTCTC AAGACATGCA CTGCCTAATT AGGTATATGT TGGAACCAGA CCCTGACAAA 
AGGCCGGATA TTTACCAGGT GTCCTACTTC TCATTTAAGC TACTCAAGAA AGAGTGCCCA 
ATTCCAAATG TACAGAACTC TCCCATTCCT GCAAAGCTTC CTGAACCAGT GAAAGCCAGT 
GAGGCAGCTG CAAAAAAGAC CCAGCCAAAG GCCAGACTGA CAGATCCCAT TCCCACCACA 
GAGACTTCAA TTGCACCCCG CCAGAGGCCT AAAGCTGGGC AGACTCAGCC GAACCCAGGA 
ATCCTTCCCA TCCAGCCAGC GCTGACACCC CGGAAGAGGG CCACTGTTCA GCCCCCACCT 
CAGGCTGCAG GATCCAGCAA TCAGCCTGGC CTTTTAGCCA GTGTTCCCCA ACCAAAACCC 
CAAGCCCCAC CCAGCCAGCC TCTGCCGCAA ACTCAGGCCA AGCAGCCACA GGCTCCTCCC 
ACTCCACAGC AGACGCCTTC TACTCAGGCC CAGGGTCTGC CCGCTCAGGC CCAGGCCACA 
CCCCAGCACC AGCAGCAACT CTTCCTCAAG CAGCAACAGC AGCAGCAACA GCCACCGCCA 
GCACAGCAGC AGCCGGCAGG CACGTTTTAC CAGCAGCAGC AGGCCCAGAC TCAGCAGTTT 
CAGGCAGTAC ATCCAGCAAC CCAGAAACCA GCAATTGCTC AGTTCCCTGT GGTGTCCCAA 
GGAGGCTCTC AACAGCAGCT AATGCAGAAT TTCTACCAGC AGCAGCAGCA GCAGCAACAA 
CAACAGCAAC AGCAACAGCT GGCCACAGCC CTGCATCAAC AACAGCTGAT GACTCAGCAG 
GCTGCCTTGC AGCAAAAGCC CACTATGGCA GCAGGACAGC AGCCCCAGCC ACAGCCAGCT 
GCAGCCCCAC AGCCAGCCCC TGCCCAGGAG CCAGCGATTC AAGCCCCAGT AAGACAACAG 
CCAAAGGTTC AGACAACCCC ACCTCCTGCC GTCCAGGGGC AGAAAGTTGG ATCTCTCACT 
CCACCCTCAT CCCCCAAAAC CCAACGTGCT GGGCACAGGC GTATTCTCAG TGACGTAACC 
CACAGTGCAG TCTTTGGGGT CCCTGCCAGC AAATCAACCC AGCTGCTCCA GGCAGCTGCA 
GCTGAGGCAG AATTGCTTGA CCCAGGGAGG CAGACTTTGC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001358506.1
CDS	400..2424
Translation	MKKFFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVRTSNGMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGGQVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGSATNKFQNPQTEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYFTLPFGESQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKLLKKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTTETSIAPRQRPKAGQTQPNPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTPQQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPATQKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQQQQQQQQLATALHQQQLMTQQAALQQKPTMAAGQQPQPQPAAAPQPAPAQEPAIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEAELLDPGRQTLQ

Target ORF information:

RefSeq Version	NM_001371577.1
Organism	Homo sapiens(human)
Definition	Homo sapiens AP2 associated kinase 1 (AAK1), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001371577.1

ORF Insert Sequence:

ATGAAGAAGT TTTTCGACTC CCGGCGAGAG CAGGGCGGCT CTGGCCTGGG CTCCGGCTCC 
AGCGGAGGAG GGGGCAGCAC CTCGGGCCTG GGCAGTGGCT ACATCGGAAG AGTCTTCGGC 
ATCGGGCGAC AGCAGGTCAC AGTGGACGAG GTGTTGGCGG AAGGTGGATT TGCTATTGTA 
TTTCTGGTGA GGACAAGCAA TGGGATGAAA TGTGCCTTGA AACGCATGTT TGTCAACAAT 
GAGCATGATC TCCAGGTGTG CAAGAGAGAA ATCCAGATAA TGAGGGATCT TTCAGGGCAC 
AAGAATATTG TGGGTTACAT TGATTCTAGT ATCAACAACG TGAGTAGCGG TGATGTATGG 
GAAGTGCTCA TTCTGATGGA CTTTTGTAGA GGTGGCCAGG TGGTAAACCT GATGAACCAG 
CGCCTGCAAA CAGGCTTTAC AGAGAATGAA GTGCTCCAGA TATTTTGTGA TACCTGTGAA 
GCTGTTGCCC GCCTGCATCA GTGCAAAACT CCTATTATCC ACCGGGACCT GAAGGTTGAA 
AACATCCTCT TGCATGACCG AGGCCACTAT GTCCTGTGTG ACTTTGGAAG CGCCACCAAC 
AAATTCCAGA ATCCACAAAC TGAGGGAGTC AATGCAGTAG AAGATGAGAT TAAGAAATAC 
ACAACGCTGT CCTATCGAGC ACCAGAAATG GTCAACCTGT ACAGTGGCAA AATCATCACT 
ACGAAGGCAG ACATTTGGGC TCTTGGATGT TTGTTGTATA AATTATGCTA CTTCACTTTG 
CCATTTGGGG AAAGTCAGGT GGCAATTTGT GATGGAAACT TCACAATTCC TGATAATTCT 
CGATATTCTC AAGACATGCA CTGCCTAATT AGGTATATGT TGGAACCAGA CCCTGACAAA 
AGGCCGGATA TTTACCAGGT GTCCTACTTC TCATTTAAGC TACTCAAGAA AGAGTGCCCA 
ATTCCAAATG TACAGAACTC TCCCATTCCT GCAAAGCTTC CTGAACCAGT GAAAGCCAGT 
GAGGCAGCTG CAAAAAAGAC CCAGCCAAAG GCCAGACTGA CAGATCCCAT TCCCACCACA 
GAGACTTCAA TTGCACCCCG CCAGAGGCCT AAAGCTGGGC AGACTCAGCC GAACCCAGGA 
ATCCTTCCCA TCCAGCCAGC GCTGACACCC CGGAAGAGGG CCACTGTTCA GCCCCCACCT 
CAGGCTGCAG GATCCAGCAA TCAGCCTGGC CTTTTAGCCA GTGTTCCCCA ACCAAAACCC 
CAAGCCCCAC CCAGCCAGCC TCTGCCGCAA ACTCAGGCCA AGCAGCCACA GGCTCCTCCC 
ACTCCACAGC AGACGCCTTC TACTCAGGCC CAGGGTCTGC CCGCTCAGGC CCAGGCCACA 
CCCCAGCACC AGCAGCAACT CTTCCTCAAG CAGCAACAGC AGCAGCAACA GCCACCGCCA 
GCACAGCAGC AGCCGGCAGG CACGTTTTAC CAGCAGCAGC AGGCCCAGAC TCAGCAGTTT 
CAGGCAGTAC ATCCAGCAAC CCAGAAACCA GCAATTGCTC AGTTCCCTGT GGTGTCCCAA 
GGAGGCTCTC AACAGCAGCT AATGCAGAAT TTCTACCAGC AGCAGCAGCA GCAGCAACAA 
CAACAGCAAC AGCAACAGCT GGCCACAGCC CTGCATCAAC AACAGCTGAT GACTCAGCAG 
GCTGCCTTGC AGCAAAAGCC CACTATGGCA GCAGGACAGC AGCCCCAGCC ACAGCCAGCT 
GCAGCCCCAC AGCCAGCCCC TGCCCAGGAG CCAGCGATTC AAGCCCCAGT AAGACAACAG 
CCAAAGGTTC AGACAACCCC ACCTCCTGCC GTCCAGGGGC AGAAAGTTGG ATCTCTCACT 
CCACCCTCAT CCCCCAAAAC CCAACGTGCT GGGCACAGGC GTATTCTCAG TGACGTAACC 
CACAGTGCAG TCTTTGGGGT CCCTGCCAGC AAATCAACCC AGCTGCTCCA GGCAGCTGCA 
GCTGAGGCAG AATTGCTTGA CCCAGGGAGG CAGACTTTGC AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Family-wide Structural Analysis of Human Numb-Associated Protein Kinases.
Structure (London, England : 1993)24(3)401-11(2016 Mar)
Sorrell FJ,Szklarz M,Abdul Azeez KR,Elkins JM,Knapp S

Integrative analysis of kinase networks in TRAIL-induced apoptosis provides a source of potential targets for combination therapy.
Science signaling8(371)rs3(2015 Apr)
So J,Pasculescu A,Dai AY,Williton K,James A,Nguyen V,Creixell P,Schoof EM,Sinclair J,Barrios-Rodiles M,Gu J,Krizus A,Williams R,Olhovsky M,Dennis JW,Wrana JL,Linding R,Jorgensen C,Pawson T,Colwill K

AP-2-associated protein kinase 1 and cyclin G-associated kinase regulate hepatitis C virus entry and are potential drug targets.
Journal of virology89(8)4387-404(2015 Apr)
Neveu G,Ziv-Av A,Barouch-Bentov R,Berkerman E,Mulholland J,Einav S

Genetic variants associated with serum thyroid stimulating hormone (TSH) levels in European Americans and African Americans from the eMERGE Network.
PloS one9(12)e111301(2014)
Malinowski JR,Denny JC,Bielinski SJ,Basford MA,Bradford Y,Peissig PL,Carrell D,Crosslin DR,Pathak J,Rasmussen L,Pacheco J,Kho A,Newton KM,Li R,Kullo IJ,Chute CG,Chisholm RL,Jarvik GP,Larson EB,McCarty CA,Masys DR,Roden DM,de Andrade M,Ritchie MD,Crawford DC

Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
Genetic epidemiology37(8)840-5(2013 Dec)
Yu B,Zheng Y,Alexander D,Manolio TA,Alonso A,Nettleton JA,Boerwinkle E

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AAK1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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