RHOBTB3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	RHOBTB3
Entrez Gene ID	22836
Full Name	Rho related BTB domain containing 3
General protein information	Preferred Names Rho related BTB domain containing 3 Names rho-related BTB domain-containing protein 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5q15
Summary	RHOBTB3 is a member of the evolutionarily conserved RHOBTB subfamily of Rho GTPases. For background information on RHOBTBs, see RHOBTB1 (MIM 607351).[supplied by OMIM, Apr 2004].
Disorder MIM:	607353

mRNA and Protein(s)

mRNA	Protein	Name
XM_011543279.2	XP_011541581.1	rho-related BTB domain-containing protein 3 isoform X1
XM_017009236.1	XP_016864725.1	rho-related BTB domain-containing protein 3 isoform X2
NM_014899.4	NP_055714.3	rho-related BTB domain-containing protein 3
XM_017009237.1	XP_016864726.1	rho-related BTB domain-containing protein 3 isoform X2
NM_014899.3	NP_055714.3	rho-related BTB domain-containing protein 3

Pathways from BioSystems

Homologies

Bos taurus (cattle)	RHOBTB3	XP_002689442.1
Mus musculus (house mouse)	Rhobtb3	NP_082769.1
Gallus gallus (chicken)	RHOBTB3	XP_004949440.1
Xenopus tropicalis (tropical clawed frog)	rhobtb3	XP_002933487.2
Homo sapiens (human)	RHOBTB3	NP_055714.3
	RHOBTB3	XP_001090858.2
Rattus norvegicus (Norway rat)	Rhobtb3	NP_001101115.1
Canis lupus familiaris (dog)	RHOBTB3	XP_005618275.1
Danio rerio (zebrafish)	si:dkey-6b12.5	XP_691270.6

Gene Ontology
Bibliography

Related articles in PubMed

Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis.
Ji W, Rivero F
Cells5(2)(2016 Jun)

RHOBTB3 promotes proteasomal degradation of HIF? through facilitating hydroxylation and suppresses the Warburg effect.
Zhang CS, Liu Q, Li M, Lin SY, Peng Y, Wu D, Li TY, Fu Q, Jia W, Wang X, Ma T, Zong Y, Cui J, Pu C, Lian G, Guo H, Ye Z, Lin SC
Cell research25(9)1025-42(2015 Sep)

Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression.
Lu A, Pfeffer SR
The Journal of cell biology203(2)233-50(2013 Oct)

RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation.
Matthys A, Van Craenenbroeck K, Lintermans B, Haegeman G, Vanhoenacker P
Cellular signalling24(5)1053-63(2012 May)

Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
Wheeler HE, Metter EJ, Tanaka T, Absher D, Higgins J, Zahn JM, Wilhelmy J, Davis RW, Singleton A, Myers RM, Ferrucci L, Kim SK
PLoS genetics5(10)e1000685(2009 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

RHOBTB3 serves as a scaffold to organize a multi-subunit complex that promotes the hydroxylation, ubiquitination and degradation of HIFalpha.
Title: RHOBTB3 promotes proteasomal degradation of HIF? through facilitating hydroxylation and suppresses the Warburg effect.

Reveal a novel role for a RhoBTB3 in catalyzing cyclin E turnover during S phase, as well as an unexpected, essential role for the Golgi as a ubiquitylation platform for cell cycle control.
Title: Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression.

The interaction between RhoBTB3 and the 5-HT7a receptor strongly inhibits proteasomal degradation of the 5-HT7a receptor.
Title: RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation.

Observational study of gene-disease association. (HuGE Navigator)
Title: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.

Study reports that the atypical Rho GTPase family member, RhoBTB3, binds directly to Rab9 GTPase and functions with Rab9 in protein transport from endosomes to the trans Golgi network.
Title: RhoBTB3: a Rho GTPase-family ATPase required for endosome to Golgi transport.

The following RHOBTB3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the RHOBTB3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26008	NM_014899.4 Latest version!	Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
OHu64968	XM_011543279.2 Latest version!	Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu95754	XM_017009237.1 Latest version!	Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu95754	XM_017009236.1 Latest version!	Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
View Old Accession Versions >>
OHu26008	NM_014899.3	Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$307.30 $439.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

RHOBTB3 ( NM_014899.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_055714.3 Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), mRNA.

Price & Availability↑

CloneID	OHu26008
Clone ID Related Accession (Same CDS sequence)	NM_014899.4 , NM_014899.3
Accession Version	NM_014899.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1836bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	rho-related BTB domain-containing protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC020231.1, CN361948.1, AB020685.1 and AC008821.6. On Nov 23, 2018 this sequence version replaced NM_014899.3. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.17452.1, SRR1660803.210960.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000379982.8/ ENSP00000369318.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCCATCC ACATCGTGGC GCTGGGGAAC GAGGGGGACA CATTCCACCA GGACAACCGG 
CCGTCGGGGC TTATCCGCAC TTACCTGGGG AGAAGCCCTC TGGTCTCCGG GGACGAGAGC 
AGCTTGTTGC TGAACGCGGC CAGCACGGTC GCGCGTCCGG TGTTCACCGA GTATCAGGCC 
AGTGCGTTTG GGAATGTCAA GCTGGTGGTC CACGACTGTC CCGTCTGGGA CATATTTGAC 
AGTGATTGGT ACACTTCTCG AAATCTAATT GGGGGCGCTG ACATCATTGT GATCAAATAC 
AACGTTAATG ACAAGTTTTC ATTCCATGAA GTAAAGGATA ATTATATTCC AGTGATAAAA 
AGAGCATTAA ATTCAGTTCC AGTAATTATT GCTGCTGTTG GTACCAGACA AAATGAAGAG 
TTACCTTGTA CATGCCCACT ATGTACCTCA GACAGAGGGA GCTGTGTTAG TACAACTGAA 
GGGATCCAAC TTGCAAAAGA ACTAGGAGCG ACCTATCTTG AACTCCACAG CCTTGATGAC 
TTCTACATAG GAAAGTATTT TGGAGGAGTG TTGGAGTATT TTATGATTCA AGCCTTAAAT 
CAGAAGACAA GTGAAAAAAT GAAGAAAAGA AAAATGAGCA ACTCCTTTCA TGGAATTAGA 
CCACCTCAAC TTGAACAACC AGAAAAAATG CCTGTCTTAA AGGCTGAAGC GTCACATTAT 
AACTCTGACT TAAATAACTT GCTGTTCTGC TGCCAGTGTG TGGACGTGGT ATTTTACAAC 
CCCAATTTAA AGAAAGTTGT AGAGGCCCAC AAGATCGTTC TCTGCGCTGT AAGCCATGTT 
TTCATGCTGC TTTTCAATGT GAAGAGTCCC ACTGACATTC AGGATTCCAG TATCATCCGA 
ACTACCCAGG ATCTTTTTGC TATAAACAGA GATACTGCAT TTCCAGGTGC TAGCCATGAA 
TCTTCAGGCA ACCCACCATT ACGAGTCATT GTTAAAGACG CCCTCTTCTG TTCTTGTTTA 
TCAGACATCC TTCGCTTCAT TTATTCAGGT GCTTTTCAGT GGGAAGAATT GGAAGAAGAT 
ATCAGGAAGA AGTTGAAAGA TTCTGGGGAT GTTTCAAATG TAATCGAGAA AGTTAAATGC 
ATTTTAAAAA CACCAGGAAA GATTAATTGC CTAAGGAATT GCAAAACCTA TCAAGCCAGA 
AAACCTTTGT GGTTTTATAA CACTTCCCTC AAGTTTTTCC TTAATAAGCC GATGCTTGCC 
GATGTTGTCT TCGAAATTCA AGGTACGACA GTGCCAGCCC ACAGGGCCAT CCTGGTGGCC 
CGTTGTGAAG TGATGGCAGC CATGTTTAAT GGTAATTACA TGGAAGCAAA GAGTGTCCTG 
ATTCCCGTTT ATGGTGTTTC CAAAGAGACT TTCTTGTCAT TTTTAGAATA CCTGTACACA 
GACTCCTGCT GCCCAGCTGG CATATTCCAG GCCATGTGTC TCCTGATCTG TGCCGAGATG 
TACCAAGTGT CCAGACTGCA GCACATCTGT GAGCTGTTCA TCATTACCCA GCTGCAGAGC 
ATGCCAAGCA GGGAACTGGC ATCCATGAAC CTTGATATAG TTGACCTGCT TAAAAAGGCC 
AAGTTTCACC ACTCTGATTG CCTTTCAACC TGGCTACTTC ATTTCATTGC TACTAACTAC 
CTCATCTTCA GTCAAAAGCC TGAATTTCAG GATCTTTCAG TGGAAGAACG CAGTTTTGTT 
GAAAAGCACA GATGGCCGTC GAATATGTAC TTGAAGCAGC TTGCGGAATA CAGGAAGTAT 
ATTCACTCCC GGAAATGTCG TTGCTTAGTA ATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055714.3
CDS	348..2183
Translation	MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLLNAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKKRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNSDLNNLLFCCQCVDVVFYNPNLKKVVEAHKIVLCAVSHVFMLLFNVKSPTDIQDSSIIRTTQDLFAINRDTAFPGASHESSGNPPLRVIVKDALFCSCLSDILRFIYSGAFQWEELEEDIRKKLKDSGDVSNVIEKVKCILKTPGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM

Target ORF information:

RefSeq Version	NM_014899.4
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014899.4

ORF Insert Sequence:

ATGTCCATCC ACATCGTGGC GCTGGGGAAC GAGGGGGACA CATTCCACCA GGACAACCGG 
CCGTCGGGGC TTATCCGCAC TTACCTGGGG AGAAGCCCTC TGGTCTCCGG GGACGAGAGC 
AGCTTGTTGC TGAACGCGGC CAGCACGGTC GCGCGTCCGG TGTTCACCGA GTATCAGGCC 
AGTGCGTTTG GGAATGTCAA GCTGGTGGTC CACGACTGTC CCGTCTGGGA CATATTTGAC 
AGTGATTGGT ACACTTCTCG AAATCTAATT GGGGGCGCTG ACATCATTGT GATCAAATAC 
AACGTTAATG ACAAGTTTTC ATTCCATGAA GTAAAGGATA ATTATATTCC AGTGATAAAA 
AGAGCATTAA ATTCAGTTCC AGTAATTATT GCTGCTGTTG GTACCAGACA AAATGAAGAG 
TTACCTTGTA CATGCCCACT ATGTACCTCA GACAGAGGGA GCTGTGTTAG TACAACTGAA 
GGGATCCAAC TTGCAAAAGA ACTAGGAGCG ACCTATCTTG AACTCCACAG CCTTGATGAC 
TTCTACATAG GAAAGTATTT TGGAGGAGTG TTGGAGTATT TTATGATTCA AGCCTTAAAT 
CAGAAGACAA GTGAAAAAAT GAAGAAAAGA AAAATGAGCA ACTCCTTTCA TGGAATTAGA 
CCACCTCAAC TTGAACAACC AGAAAAAATG CCTGTCTTAA AGGCTGAAGC GTCACATTAT 
AACTCTGACT TAAATAACTT GCTGTTCTGC TGCCAGTGTG TGGACGTGGT ATTTTACAAC 
CCCAATTTAA AGAAAGTTGT AGAGGCCCAC AAGATCGTTC TCTGCGCTGT AAGCCATGTT 
TTCATGCTGC TTTTCAATGT GAAGAGTCCC ACTGACATTC AGGATTCCAG TATCATCCGA 
ACTACCCAGG ATCTTTTTGC TATAAACAGA GATACTGCAT TTCCAGGTGC TAGCCATGAA 
TCTTCAGGCA ACCCACCATT ACGAGTCATT GTTAAAGACG CCCTCTTCTG TTCTTGTTTA 
TCAGACATCC TTCGCTTCAT TTATTCAGGT GCTTTTCAGT GGGAAGAATT GGAAGAAGAT 
ATCAGGAAGA AGTTGAAAGA TTCTGGGGAT GTTTCAAATG TAATCGAGAA AGTTAAATGC 
ATTTTAAAAA CACCAGGAAA GATTAATTGC CTAAGGAATT GCAAAACCTA TCAAGCCAGA 
AAACCTTTGT GGTTTTATAA CACTTCCCTC AAGTTTTTCC TTAATAAGCC GATGCTTGCC 
GATGTTGTCT TCGAAATTCA AGGTACGACA GTGCCAGCCC ACAGGGCCAT CCTGGTGGCC 
CGTTGTGAAG TGATGGCAGC CATGTTTAAT GGTAATTACA TGGAAGCAAA GAGTGTCCTG 
ATTCCCGTTT ATGGTGTTTC CAAAGAGACT TTCTTGTCAT TTTTAGAATA CCTGTACACA 
GACTCCTGCT GCCCAGCTGG CATATTCCAG GCCATGTGTC TCCTGATCTG TGCCGAGATG 
TACCAAGTGT CCAGACTGCA GCACATCTGT GAGCTGTTCA TCATTACCCA GCTGCAGAGC 
ATGCCAAGCA GGGAACTGGC ATCCATGAAC CTTGATATAG TTGACCTGCT TAAAAAGGCC 
AAGTTTCACC ACTCTGATTG CCTTTCAACC TGGCTACTTC ATTTCATTGC TACTAACTAC 
CTCATCTTCA GTCAAAAGCC TGAATTTCAG GATCTTTCAG TGGAAGAACG CAGTTTTGTT 
GAAAAGCACA GATGGCCGTC GAATATGTAC TTGAAGCAGC TTGCGGAATA CAGGAAGTAT 
ATTCACTCCC GGAAATGTCG TTGCTTAGTA ATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOBTB3 ( NM_014899.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_055714.3 Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), mRNA.

Price & Availability↑

CloneID	OHu26008
Clone ID Related Accession (Same CDS sequence)	NM_014899.4 , NM_014899.3
Accession Version	NM_014899.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1836bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	rho-related BTB domain-containing protein 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC047884.1, BC020231.1, CN361948.1, AB020685.1 and AC008821.6. On Sep 30, 2006 this sequence version replaced NM_014899.2. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.17452.1, SRR1660803.210960.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGTCCATCC ACATCGTGGC GCTGGGGAAC GAGGGGGACA CATTCCACCA GGACAACCGG 
CCGTCGGGGC TTATCCGCAC TTACCTGGGG AGAAGCCCTC TGGTCTCCGG GGACGAGAGC 
AGCTTGTTGC TGAACGCGGC CAGCACGGTC GCGCGTCCGG TGTTCACCGA GTATCAGGCC 
AGTGCGTTTG GGAATGTCAA GCTGGTGGTC CACGACTGTC CCGTCTGGGA CATATTTGAC 
AGTGATTGGT ACACTTCTCG AAATCTAATT GGGGGCGCTG ACATCATTGT GATCAAATAC 
AACGTTAATG ACAAGTTTTC ATTCCATGAA GTAAAGGATA ATTATATTCC AGTGATAAAA 
AGAGCATTAA ATTCAGTTCC AGTAATTATT GCTGCTGTTG GTACCAGACA AAATGAAGAG 
TTACCTTGTA CATGCCCACT ATGTACCTCA GACAGAGGGA GCTGTGTTAG TACAACTGAA 
GGGATCCAAC TTGCAAAAGA ACTAGGAGCG ACCTATCTTG AACTCCACAG CCTTGATGAC 
TTCTACATAG GAAAGTATTT TGGAGGAGTG TTGGAGTATT TTATGATTCA AGCCTTAAAT 
CAGAAGACAA GTGAAAAAAT GAAGAAAAGA AAAATGAGCA ACTCCTTTCA TGGAATTAGA 
CCACCTCAAC TTGAACAACC AGAAAAAATG CCTGTCTTAA AGGCTGAAGC GTCACATTAT 
AACTCTGACT TAAATAACTT GCTGTTCTGC TGCCAGTGTG TGGACGTGGT ATTTTACAAC 
CCCAATTTAA AGAAAGTTGT AGAGGCCCAC AAGATCGTTC TCTGCGCTGT AAGCCATGTT 
TTCATGCTGC TTTTCAATGT GAAGAGTCCC ACTGACATTC AGGATTCCAG TATCATCCGA 
ACTACCCAGG ATCTTTTTGC TATAAACAGA GATACTGCAT TTCCAGGTGC TAGCCATGAA 
TCTTCAGGCA ACCCACCATT ACGAGTCATT GTTAAAGACG CCCTCTTCTG TTCTTGTTTA 
TCAGACATCC TTCGCTTCAT TTATTCAGGT GCTTTTCAGT GGGAAGAATT GGAAGAAGAT 
ATCAGGAAGA AGTTGAAAGA TTCTGGGGAT GTTTCAAATG TAATCGAGAA AGTTAAATGC 
ATTTTAAAAA CACCAGGAAA GATTAATTGC CTAAGGAATT GCAAAACCTA TCAAGCCAGA 
AAACCTTTGT GGTTTTATAA CACTTCCCTC AAGTTTTTCC TTAATAAGCC GATGCTTGCC 
GATGTTGTCT TCGAAATTCA AGGTACGACA GTGCCAGCCC ACAGGGCCAT CCTGGTGGCC 
CGTTGTGAAG TGATGGCAGC CATGTTTAAT GGTAATTACA TGGAAGCAAA GAGTGTCCTG 
ATTCCCGTTT ATGGTGTTTC CAAAGAGACT TTCTTGTCAT TTTTAGAATA CCTGTACACA 
GACTCCTGCT GCCCAGCTGG CATATTCCAG GCCATGTGTC TCCTGATCTG TGCCGAGATG 
TACCAAGTGT CCAGACTGCA GCACATCTGT GAGCTGTTCA TCATTACCCA GCTGCAGAGC 
ATGCCAAGCA GGGAACTGGC ATCCATGAAC CTTGATATAG TTGACCTGCT TAAAAAGGCC 
AAGTTTCACC ACTCTGATTG CCTTTCAACC TGGCTACTTC ATTTCATTGC TACTAACTAC 
CTCATCTTCA GTCAAAAGCC TGAATTTCAG GATCTTTCAG TGGAAGAACG CAGTTTTGTT 
GAAAAGCACA GATGGCCGTC GAATATGTAC TTGAAGCAGC TTGCGGAATA CAGGAAGTAT 
ATTCACTCCC GGAAATGTCG TTGCTTAGTA ATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_055714.3
CDS	538..2373
Translation	MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLLNAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKKRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNSDLNNLLFCCQCVDVVFYNPNLKKVVEAHKIVLCAVSHVFMLLFNVKSPTDIQDSSIIRTTQDLFAINRDTAFPGASHESSGNPPLRVIVKDALFCSCLSDILRFIYSGAFQWEELEEDIRKKLKDSGDVSNVIEKVKCILKTPGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM

Target ORF information:

RefSeq Version	NM_014899.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014899.3

ORF Insert Sequence:

ATGTCCATCC ACATCGTGGC GCTGGGGAAC GAGGGGGACA CATTCCACCA GGACAACCGG 
CCGTCGGGGC TTATCCGCAC TTACCTGGGG AGAAGCCCTC TGGTCTCCGG GGACGAGAGC 
AGCTTGTTGC TGAACGCGGC CAGCACGGTC GCGCGTCCGG TGTTCACCGA GTATCAGGCC 
AGTGCGTTTG GGAATGTCAA GCTGGTGGTC CACGACTGTC CCGTCTGGGA CATATTTGAC 
AGTGATTGGT ACACTTCTCG AAATCTAATT GGGGGCGCTG ACATCATTGT GATCAAATAC 
AACGTTAATG ACAAGTTTTC ATTCCATGAA GTAAAGGATA ATTATATTCC AGTGATAAAA 
AGAGCATTAA ATTCAGTTCC AGTAATTATT GCTGCTGTTG GTACCAGACA AAATGAAGAG 
TTACCTTGTA CATGCCCACT ATGTACCTCA GACAGAGGGA GCTGTGTTAG TACAACTGAA 
GGGATCCAAC TTGCAAAAGA ACTAGGAGCG ACCTATCTTG AACTCCACAG CCTTGATGAC 
TTCTACATAG GAAAGTATTT TGGAGGAGTG TTGGAGTATT TTATGATTCA AGCCTTAAAT 
CAGAAGACAA GTGAAAAAAT GAAGAAAAGA AAAATGAGCA ACTCCTTTCA TGGAATTAGA 
CCACCTCAAC TTGAACAACC AGAAAAAATG CCTGTCTTAA AGGCTGAAGC GTCACATTAT 
AACTCTGACT TAAATAACTT GCTGTTCTGC TGCCAGTGTG TGGACGTGGT ATTTTACAAC 
CCCAATTTAA AGAAAGTTGT AGAGGCCCAC AAGATCGTTC TCTGCGCTGT AAGCCATGTT 
TTCATGCTGC TTTTCAATGT GAAGAGTCCC ACTGACATTC AGGATTCCAG TATCATCCGA 
ACTACCCAGG ATCTTTTTGC TATAAACAGA GATACTGCAT TTCCAGGTGC TAGCCATGAA 
TCTTCAGGCA ACCCACCATT ACGAGTCATT GTTAAAGACG CCCTCTTCTG TTCTTGTTTA 
TCAGACATCC TTCGCTTCAT TTATTCAGGT GCTTTTCAGT GGGAAGAATT GGAAGAAGAT 
ATCAGGAAGA AGTTGAAAGA TTCTGGGGAT GTTTCAAATG TAATCGAGAA AGTTAAATGC 
ATTTTAAAAA CACCAGGAAA GATTAATTGC CTAAGGAATT GCAAAACCTA TCAAGCCAGA 
AAACCTTTGT GGTTTTATAA CACTTCCCTC AAGTTTTTCC TTAATAAGCC GATGCTTGCC 
GATGTTGTCT TCGAAATTCA AGGTACGACA GTGCCAGCCC ACAGGGCCAT CCTGGTGGCC 
CGTTGTGAAG TGATGGCAGC CATGTTTAAT GGTAATTACA TGGAAGCAAA GAGTGTCCTG 
ATTCCCGTTT ATGGTGTTTC CAAAGAGACT TTCTTGTCAT TTTTAGAATA CCTGTACACA 
GACTCCTGCT GCCCAGCTGG CATATTCCAG GCCATGTGTC TCCTGATCTG TGCCGAGATG 
TACCAAGTGT CCAGACTGCA GCACATCTGT GAGCTGTTCA TCATTACCCA GCTGCAGAGC 
ATGCCAAGCA GGGAACTGGC ATCCATGAAC CTTGATATAG TTGACCTGCT TAAAAAGGCC 
AAGTTTCACC ACTCTGATTG CCTTTCAACC TGGCTACTTC ATTTCATTGC TACTAACTAC 
CTCATCTTCA GTCAAAAGCC TGAATTTCAG GATCTTTCAG TGGAAGAACG CAGTTTTGTT 
GAAAAGCACA GATGGCCGTC GAATATGTAC TTGAAGCAGC TTGCGGAATA CAGGAAGTAT 
ATTCACTCCC GGAAATGTCG TTGCTTAGTA ATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOBTB3 ( XM_011543279.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011541581.1 Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu64968
Clone ID Related Accession (Same CDS sequence)	XM_011543279.2
Accession Version	XM_011543279.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1470bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rho-related BTB domain-containing protein 3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011543279.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCCATCC ACATCGTGGC GCTGGGGAAC GAGGGGGACA CATTCCACCA GGACAACCGG 
CCGTCGGGGC TTATCCGCAC TTACCTGGGG AGAAGCCCTC TGGTCTCCGG GGACGAGAGC 
AGCTTGTTGC TGAACGCGGC CAGCACGGTC GCGCGTCCGG TGTTCACCGA GTATCAGGCC 
AGTGCGTTTG GGAATGTCAA GCTGGTGGTC CACGACTGTC CCGTCTGGGA CATATTTGAC 
AGTGATTGGT ACACTTCTCG AAATCTAATT GGGGGCGCTG ACATCATTGT GATCAAATAC 
AACGTTAATG ACAAGTTTTC ATTCCATGAA GTAAAGGATA ATTATATTCC AGTGATAAAA 
AGAGCATTAA ATTCAGTTCC AGTAATTATT GCTGCTGTTG GTACCAGACA AAATGAAGAG 
TTACCTTGTA CATGCCCACT ATGTACCTCA GACAGAGGGA GCTGTGTTAG TACAACTGAA 
GGGATCCAAC TTGCAAAAGA ACTAGGAGCG ACCTATCTTG AACTCCACAG CCTTGATGAC 
TTCTACATAG GAAAGTATTT TGGAGGAGTG TTGGAGTATT TTATGATTCA AGCCTTAAAT 
CAGAAGACAA GTGAAAAAAT GAAGAAAAGA AAAATGAGCA ACTCCTTTCA TGGAATTAGA 
CCACCTCAAC TTGAACAACC AGGTGCTTTT CAGTGGGAAG AATTGGAAGA AGATATCAGG 
AAGAAGTTGA AAGATTCTGG GGATGTTTCA AATGTAATCG AGAAAGTTAA ATGCATTTTA 
AAAACACCAG GAAAGATTAA TTGCCTAAGG AATTGCAAAA CCTATCAAGC CAGAAAACCT 
TTGTGGTTTT ATAACACTTC CCTCAAGTTT TTCCTTAATA AGCCGATGCT TGCCGATGTT 
GTCTTCGAAA TTCAAGGTAC GACAGTGCCA GCCCACAGGG CCATCCTGGT GGCCCGTTGT 
GAAGTGATGG CAGCCATGTT TAATGGTAAT TACATGGAAG CAAAGAGTGT CCTGATTCCC 
GTTTATGGTG TTTCCAAAGA GACTTTCTTG TCATTTTTAG AATACCTGTA CACAGACTCC 
TGCTGCCCAG CTGGCATATT CCAGGCCATG TGTCTCCTGA TCTGTGCCGA GATGTACCAA 
GTGTCCAGAC TGCAGCACAT CTGTGAGCTG TTCATCATTA CCCAGCTGCA GAGCATGCCA 
AGCAGGGAAC TGGCATCCAT GAACCTTGAT ATAGTTGACC TGCTTAAAAA GGCCAAGTTT 
CACCACTCTG ATTGCCTTTC AACCTGGCTA CTTCATTTCA TTGCTACTAA CTACCTCATC 
TTCAGTCAAA AGCCTGAATT TCAGGATCTT TCAGTGGAAG AACGCAGTTT TGTTGAAAAG 
CACAGATGGC CGTCGAATAT GTACTTGAAG CAGCTTGCGG AATACAGGAA GTATATTCAC 
TCCCGGAAAT GTCGTTGCTT AGTAATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011541581.1
CDS	618..2087
Translation	MSIHIVALGNEGDTFHQDNRPSGLIRTYLGRSPLVSGDESSLLLNAASTVARPVFTEYQASAFGNVKLVVHDCPVWDIFDSDWYTSRNLIGGADIIVIKYNVNDKFSFHEVKDNYIPVIKRALNSVPVIIAAVGTRQNEELPCTCPLCTSDRGSCVSTTEGIQLAKELGATYLELHSLDDFYIGKYFGGVLEYFMIQALNQKTSEKMKKRKMSNSFHGIRPPQLEQPGAFQWEELEEDIRKKLKDSGDVSNVIEKVKCILKTPGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM

Target ORF information:

RefSeq Version	XM_011543279.2
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011543279.2

ORF Insert Sequence:

ATGTCCATCC ACATCGTGGC GCTGGGGAAC GAGGGGGACA CATTCCACCA GGACAACCGG 
CCGTCGGGGC TTATCCGCAC TTACCTGGGG AGAAGCCCTC TGGTCTCCGG GGACGAGAGC 
AGCTTGTTGC TGAACGCGGC CAGCACGGTC GCGCGTCCGG TGTTCACCGA GTATCAGGCC 
AGTGCGTTTG GGAATGTCAA GCTGGTGGTC CACGACTGTC CCGTCTGGGA CATATTTGAC 
AGTGATTGGT ACACTTCTCG AAATCTAATT GGGGGCGCTG ACATCATTGT GATCAAATAC 
AACGTTAATG ACAAGTTTTC ATTCCATGAA GTAAAGGATA ATTATATTCC AGTGATAAAA 
AGAGCATTAA ATTCAGTTCC AGTAATTATT GCTGCTGTTG GTACCAGACA AAATGAAGAG 
TTACCTTGTA CATGCCCACT ATGTACCTCA GACAGAGGGA GCTGTGTTAG TACAACTGAA 
GGGATCCAAC TTGCAAAAGA ACTAGGAGCG ACCTATCTTG AACTCCACAG CCTTGATGAC 
TTCTACATAG GAAAGTATTT TGGAGGAGTG TTGGAGTATT TTATGATTCA AGCCTTAAAT 
CAGAAGACAA GTGAAAAAAT GAAGAAAAGA AAAATGAGCA ACTCCTTTCA TGGAATTAGA 
CCACCTCAAC TTGAACAACC AGGTGCTTTT CAGTGGGAAG AATTGGAAGA AGATATCAGG 
AAGAAGTTGA AAGATTCTGG GGATGTTTCA AATGTAATCG AGAAAGTTAA ATGCATTTTA 
AAAACACCAG GAAAGATTAA TTGCCTAAGG AATTGCAAAA CCTATCAAGC CAGAAAACCT 
TTGTGGTTTT ATAACACTTC CCTCAAGTTT TTCCTTAATA AGCCGATGCT TGCCGATGTT 
GTCTTCGAAA TTCAAGGTAC GACAGTGCCA GCCCACAGGG CCATCCTGGT GGCCCGTTGT 
GAAGTGATGG CAGCCATGTT TAATGGTAAT TACATGGAAG CAAAGAGTGT CCTGATTCCC 
GTTTATGGTG TTTCCAAAGA GACTTTCTTG TCATTTTTAG AATACCTGTA CACAGACTCC 
TGCTGCCCAG CTGGCATATT CCAGGCCATG TGTCTCCTGA TCTGTGCCGA GATGTACCAA 
GTGTCCAGAC TGCAGCACAT CTGTGAGCTG TTCATCATTA CCCAGCTGCA GAGCATGCCA 
AGCAGGGAAC TGGCATCCAT GAACCTTGAT ATAGTTGACC TGCTTAAAAA GGCCAAGTTT 
CACCACTCTG ATTGCCTTTC AACCTGGCTA CTTCATTTCA TTGCTACTAA CTACCTCATC 
TTCAGTCAAA AGCCTGAATT TCAGGATCTT TCAGTGGAAG AACGCAGTTT TGTTGAAAAG 
CACAGATGGC CGTCGAATAT GTACTTGAAG CAGCTTGCGG AATACAGGAA GTATATTCAC 
TCCCGGAAAT GTCGTTGCTT AGTAATGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOBTB3 ( XM_017009236.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016864725.1 Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu95754
Clone ID Related Accession (Same CDS sequence)	XM_017009236.1 , XM_017009237.1
Accession Version	XM_017009236.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rho-related BTB domain-containing protein 3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTCAAG CCTTAAATCA GAAGACAAGT GAAAAAATGA AGAAAAGAAA AATGAGCAAC 
TCCTTTCATG GAATTAGACC ACCTCAACTT GAACAACCAG AAAAAATGCC TGTCTTAAAG 
GCTGAAGCGT CACATTATAA CTCTGACTTA AATAACTTGC TGTTCTGCTG CCAGTGTGTG 
GACGTGGTAT TTTACAACCC CAATTTAAAG AAAGTTGTAG AGGCCCACAA GATCGTTCTC 
TGCGCTGTAA GCCATGTTTT CATGCTGCTT TTCAATGTGA AGAGTCCCAC TGACATTCAG 
GATTCCAGTA TCATCCGAAC TACCCAGGAT CTTTTTGCTA TAAACAGAGA TACTGCATTT 
CCAGGTGCTA GCCATGAATC TTCAGGCAAC CCACCATTAC GAGTCATTGT TAAAGACGCC 
CTCTTCTGTT CTTGTTTATC AGACATCCTT CGCTTCATTT ATTCAGGTGC TTTTCAGTGG 
GAAGAATTGG AAGAAGATAT CAGGAAGAAG TTGAAAGATT CTGGGGATGT TTCAAATGTA 
ATCGAGAAAG TTAAATGCAT TTTAAAAACA CCAGGAAAGA TTAATTGCCT AAGGAATTGC 
AAAACCTATC AAGCCAGAAA ACCTTTGTGG TTTTATAACA CTTCCCTCAA GTTTTTCCTT 
AATAAGCCGA TGCTTGCCGA TGTTGTCTTC GAAATTCAAG GTACGACAGT GCCAGCCCAC 
AGGGCCATCC TGGTGGCCCG TTGTGAAGTG ATGGCAGCCA TGTTTAATGG TAATTACATG 
GAAGCAAAGA GTGTCCTGAT TCCCGTTTAT GGTGTTTCCA AAGAGACTTT CTTGTCATTT 
TTAGAATACC TGTACACAGA CTCCTGCTGC CCAGCTGGCA TATTCCAGGC CATGTGTCTC 
CTGATCTGTG CCGAGATGTA CCAAGTGTCC AGACTGCAGC ACATCTGTGA GCTGTTCATC 
ATTACCCAGC TGCAGAGCAT GCCAAGCAGG GAACTGGCAT CCATGAACCT TGATATAGTT 
GACCTGCTTA AAAAGGCCAA GTTTCACCAC TCTGATTGCC TTTCAACCTG GCTACTTCAT 
TTCATTGCTA CTAACTACCT CATCTTCAGT CAAAAGCCTG AATTTCAGGA TCTTTCAGTG 
GAAGAACGCA GTTTTGTTGA AAAGCACAGA TGGCCGTCGA ATATGTACTT GAAGCAGCTT 
GCGGAATACA GGAAGTATAT TCACTCCCGG AAATGTCGTT GCTTAGTAAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016864725.1
CDS	881..2134
Translation	MIQALNQKTSEKMKKRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNSDLNNLLFCCQCVDVVFYNPNLKKVVEAHKIVLCAVSHVFMLLFNVKSPTDIQDSSIIRTTQDLFAINRDTAFPGASHESSGNPPLRVIVKDALFCSCLSDILRFIYSGAFQWEELEEDIRKKLKDSGDVSNVIEKVKCILKTPGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM

Target ORF information:

RefSeq Version	XM_017009236.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017009236.1

ORF Insert Sequence:

ATGATTCAAG CCTTAAATCA GAAGACAAGT GAAAAAATGA AGAAAAGAAA AATGAGCAAC 
TCCTTTCATG GAATTAGACC ACCTCAACTT GAACAACCAG AAAAAATGCC TGTCTTAAAG 
GCTGAAGCGT CACATTATAA CTCTGACTTA AATAACTTGC TGTTCTGCTG CCAGTGTGTG 
GACGTGGTAT TTTACAACCC CAATTTAAAG AAAGTTGTAG AGGCCCACAA GATCGTTCTC 
TGCGCTGTAA GCCATGTTTT CATGCTGCTT TTCAATGTGA AGAGTCCCAC TGACATTCAG 
GATTCCAGTA TCATCCGAAC TACCCAGGAT CTTTTTGCTA TAAACAGAGA TACTGCATTT 
CCAGGTGCTA GCCATGAATC TTCAGGCAAC CCACCATTAC GAGTCATTGT TAAAGACGCC 
CTCTTCTGTT CTTGTTTATC AGACATCCTT CGCTTCATTT ATTCAGGTGC TTTTCAGTGG 
GAAGAATTGG AAGAAGATAT CAGGAAGAAG TTGAAAGATT CTGGGGATGT TTCAAATGTA 
ATCGAGAAAG TTAAATGCAT TTTAAAAACA CCAGGAAAGA TTAATTGCCT AAGGAATTGC 
AAAACCTATC AAGCCAGAAA ACCTTTGTGG TTTTATAACA CTTCCCTCAA GTTTTTCCTT 
AATAAGCCGA TGCTTGCCGA TGTTGTCTTC GAAATTCAAG GTACGACAGT GCCAGCCCAC 
AGGGCCATCC TGGTGGCCCG TTGTGAAGTG ATGGCAGCCA TGTTTAATGG TAATTACATG 
GAAGCAAAGA GTGTCCTGAT TCCCGTTTAT GGTGTTTCCA AAGAGACTTT CTTGTCATTT 
TTAGAATACC TGTACACAGA CTCCTGCTGC CCAGCTGGCA TATTCCAGGC CATGTGTCTC 
CTGATCTGTG CCGAGATGTA CCAAGTGTCC AGACTGCAGC ACATCTGTGA GCTGTTCATC 
ATTACCCAGC TGCAGAGCAT GCCAAGCAGG GAACTGGCAT CCATGAACCT TGATATAGTT 
GACCTGCTTA AAAAGGCCAA GTTTCACCAC TCTGATTGCC TTTCAACCTG GCTACTTCAT 
TTCATTGCTA CTAACTACCT CATCTTCAGT CAAAAGCCTG AATTTCAGGA TCTTTCAGTG 
GAAGAACGCA GTTTTGTTGA AAAGCACAGA TGGCCGTCGA ATATGTACTT GAAGCAGCTT 
GCGGAATACA GGAAGTATAT TCACTCCCGG AAATGTCGTT GCTTAGTAAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RHOBTB3 ( XM_017009237.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016864726.1 Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu95754
Clone ID Related Accession (Same CDS sequence)	XM_017009236.1 , XM_017009237.1
Accession Version	XM_017009237.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1254bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rho-related BTB domain-containing protein 3 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATTCAAG CCTTAAATCA GAAGACAAGT GAAAAAATGA AGAAAAGAAA AATGAGCAAC 
TCCTTTCATG GAATTAGACC ACCTCAACTT GAACAACCAG AAAAAATGCC TGTCTTAAAG 
GCTGAAGCGT CACATTATAA CTCTGACTTA AATAACTTGC TGTTCTGCTG CCAGTGTGTG 
GACGTGGTAT TTTACAACCC CAATTTAAAG AAAGTTGTAG AGGCCCACAA GATCGTTCTC 
TGCGCTGTAA GCCATGTTTT CATGCTGCTT TTCAATGTGA AGAGTCCCAC TGACATTCAG 
GATTCCAGTA TCATCCGAAC TACCCAGGAT CTTTTTGCTA TAAACAGAGA TACTGCATTT 
CCAGGTGCTA GCCATGAATC TTCAGGCAAC CCACCATTAC GAGTCATTGT TAAAGACGCC 
CTCTTCTGTT CTTGTTTATC AGACATCCTT CGCTTCATTT ATTCAGGTGC TTTTCAGTGG 
GAAGAATTGG AAGAAGATAT CAGGAAGAAG TTGAAAGATT CTGGGGATGT TTCAAATGTA 
ATCGAGAAAG TTAAATGCAT TTTAAAAACA CCAGGAAAGA TTAATTGCCT AAGGAATTGC 
AAAACCTATC AAGCCAGAAA ACCTTTGTGG TTTTATAACA CTTCCCTCAA GTTTTTCCTT 
AATAAGCCGA TGCTTGCCGA TGTTGTCTTC GAAATTCAAG GTACGACAGT GCCAGCCCAC 
AGGGCCATCC TGGTGGCCCG TTGTGAAGTG ATGGCAGCCA TGTTTAATGG TAATTACATG 
GAAGCAAAGA GTGTCCTGAT TCCCGTTTAT GGTGTTTCCA AAGAGACTTT CTTGTCATTT 
TTAGAATACC TGTACACAGA CTCCTGCTGC CCAGCTGGCA TATTCCAGGC CATGTGTCTC 
CTGATCTGTG CCGAGATGTA CCAAGTGTCC AGACTGCAGC ACATCTGTGA GCTGTTCATC 
ATTACCCAGC TGCAGAGCAT GCCAAGCAGG GAACTGGCAT CCATGAACCT TGATATAGTT 
GACCTGCTTA AAAAGGCCAA GTTTCACCAC TCTGATTGCC TTTCAACCTG GCTACTTCAT 
TTCATTGCTA CTAACTACCT CATCTTCAGT CAAAAGCCTG AATTTCAGGA TCTTTCAGTG 
GAAGAACGCA GTTTTGTTGA AAAGCACAGA TGGCCGTCGA ATATGTACTT GAAGCAGCTT 
GCGGAATACA GGAAGTATAT TCACTCCCGG AAATGTCGTT GCTTAGTAAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016864726.1
CDS	1002..2255
Translation	MIQALNQKTSEKMKKRKMSNSFHGIRPPQLEQPEKMPVLKAEASHYNSDLNNLLFCCQCVDVVFYNPNLKKVVEAHKIVLCAVSHVFMLLFNVKSPTDIQDSSIIRTTQDLFAINRDTAFPGASHESSGNPPLRVIVKDALFCSCLSDILRFIYSGAFQWEELEEDIRKKLKDSGDVSNVIEKVKCILKTPGKINCLRNCKTYQARKPLWFYNTSLKFFLNKPMLADVVFEIQGTTVPAHRAILVARCEVMAAMFNGNYMEAKSVLIPVYGVSKETFLSFLEYLYTDSCCPAGIFQAMCLLICAEMYQVSRLQHICELFIITQLQSMPSRELASMNLDIVDLLKKAKFHHSDCLSTWLLHFIATNYLIFSQKPEFQDLSVEERSFVEKHRWPSNMYLKQLAEYRKYIHSRKCRCLVM

Target ORF information:

RefSeq Version	XM_017009237.1
Organism	Homo sapiens(human)
Definition	Homo sapiens Rho related BTB domain containing 3 (RHOBTB3), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017009237.1

ORF Insert Sequence:

ATGATTCAAG CCTTAAATCA GAAGACAAGT GAAAAAATGA AGAAAAGAAA AATGAGCAAC 
TCCTTTCATG GAATTAGACC ACCTCAACTT GAACAACCAG AAAAAATGCC TGTCTTAAAG 
GCTGAAGCGT CACATTATAA CTCTGACTTA AATAACTTGC TGTTCTGCTG CCAGTGTGTG 
GACGTGGTAT TTTACAACCC CAATTTAAAG AAAGTTGTAG AGGCCCACAA GATCGTTCTC 
TGCGCTGTAA GCCATGTTTT CATGCTGCTT TTCAATGTGA AGAGTCCCAC TGACATTCAG 
GATTCCAGTA TCATCCGAAC TACCCAGGAT CTTTTTGCTA TAAACAGAGA TACTGCATTT 
CCAGGTGCTA GCCATGAATC TTCAGGCAAC CCACCATTAC GAGTCATTGT TAAAGACGCC 
CTCTTCTGTT CTTGTTTATC AGACATCCTT CGCTTCATTT ATTCAGGTGC TTTTCAGTGG 
GAAGAATTGG AAGAAGATAT CAGGAAGAAG TTGAAAGATT CTGGGGATGT TTCAAATGTA 
ATCGAGAAAG TTAAATGCAT TTTAAAAACA CCAGGAAAGA TTAATTGCCT AAGGAATTGC 
AAAACCTATC AAGCCAGAAA ACCTTTGTGG TTTTATAACA CTTCCCTCAA GTTTTTCCTT 
AATAAGCCGA TGCTTGCCGA TGTTGTCTTC GAAATTCAAG GTACGACAGT GCCAGCCCAC 
AGGGCCATCC TGGTGGCCCG TTGTGAAGTG ATGGCAGCCA TGTTTAATGG TAATTACATG 
GAAGCAAAGA GTGTCCTGAT TCCCGTTTAT GGTGTTTCCA AAGAGACTTT CTTGTCATTT 
TTAGAATACC TGTACACAGA CTCCTGCTGC CCAGCTGGCA TATTCCAGGC CATGTGTCTC 
CTGATCTGTG CCGAGATGTA CCAAGTGTCC AGACTGCAGC ACATCTGTGA GCTGTTCATC 
ATTACCCAGC TGCAGAGCAT GCCAAGCAGG GAACTGGCAT CCATGAACCT TGATATAGTT 
GACCTGCTTA AAAAGGCCAA GTTTCACCAC TCTGATTGCC TTTCAACCTG GCTACTTCAT 
TTCATTGCTA CTAACTACCT CATCTTCAGT CAAAAGCCTG AATTTCAGGA TCTTTCAGTG 
GAAGAACGCA GTTTTGTTGA AAAGCACAGA TGGCCGTCGA ATATGTACTT GAAGCAGCTT 
GCGGAATACA GGAAGTATAT TCACTCCCGG AAATGTCGTT GCTTAGTAAT GTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Atypical Rho GTPases of the RhoBTB Subfamily: Roles in Vesicle Trafficking and Tumorigenesis.
Cells5(2)(2016 Jun)
Ji W,Rivero F

RHOBTB3 promotes proteasomal degradation of HIF? through facilitating hydroxylation and suppresses the Warburg effect.
Cell research25(9)1025-42(2015 Sep)
Zhang CS,Liu Q,Li M,Lin SY,Peng Y,Wu D,Li TY,Fu Q,Jia W,Wang X,Ma T,Zong Y,Cui J,Pu C,Lian G,Guo H,Ye Z,Lin SC

Golgi-associated RhoBTB3 targets cyclin E for ubiquitylation and promotes cell cycle progression.
The Journal of cell biology203(2)233-50(2013 Oct)
Lu A,Pfeffer SR

RhoBTB3 interacts with the 5-HT7a receptor and inhibits its proteasomal degradation.
Cellular signalling24(5)1053-63(2012 May)
Matthys A,Van Craenenbroeck K,Lintermans B,Haegeman G,Vanhoenacker P

Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
PLoS genetics5(10)e1000685(2009 Oct)
Wheeler HE,Metter EJ,Tanaka T,Absher D,Higgins J,Zahn JM,Wilhelmy J,Davis RW,Singleton A,Myers RM,Ferrucci L,Kim SK

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RHOBTB3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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