Gene Symbol | PUF60 |
Entrez Gene ID | 22827 |
Full Name | poly(U) binding splicing factor 60 |
Synonyms | FIR,RoBPI,SIAHBP1,VRJS |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a nucleic acid-binding protein that plays a role in a variety of nuclear processes, including pre-mRNA splicing and transcriptional regulation. The encoded protein forms a complex with the far upstream DNA element (FUSE) and FUSE-binding protein at the myelocytomatosis oncogene (MYC) promoter. This complex represses MYC transcription through the core-TFIIH basal transcription factor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2012]. |
Disorder MIM: | |
Disorder Html: | Verheij syndrome, 615583 (3) |