XRN2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	XRN2
Entrez Gene ID	22803
Full Name	5'-3' exoribonuclease 2
General protein information	Preferred Names 5'-3' exoribonuclease 2 Names 5'-3' exoribonuclease 2 DHP protein Dhm1-like protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 20 Map Location: 20p11.22
Summary	This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
Disorder MIM:	608851

mRNA and Protein(s)

mRNA	Protein	Name
XM_017027723.1	XP_016883212.1	5'-3' exoribonuclease 2 isoform X2
NM_012255.5	NP_036387.2	5'-3' exoribonuclease 2 isoform 2
NM_001317960.1	NP_001304889.1	5'-3' exoribonuclease 2 isoform 1
XM_017027722.1	XP_016883211.1	5'-3' exoribonuclease 2 isoform X1
XM_017027723.2	XP_016883212.1	5'-3' exoribonuclease 2 isoform X2
NM_012255.4	NP_036387.2	5'-3' exoribonuclease 2 isoform 2
XM_017027724.1	XP_016883213.1	5'-3' exoribonuclease 2 isoform X3

Pathways from BioSystems

Homologies

Eremothecium gossypii	AGOS_AGR303W	NP_986969.2
Pan troglodytes (chimpanzee)	XRN2	XP_514546.2
Canis lupus familiaris (dog)	XRN2	XP_534324.2
Rattus norvegicus (Norway rat)	Xrn2	NP_001102066.1
Drosophila melanogaster (fruit fly)	Rat1	NP_001260166.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004090	XP_309641.5
Caenorhabditis elegans (roundworm)	xrn-2	NP_496958.2
Saccharomyces cerevisiae (baker's yeast)	RAT1	NP_014691.1
Xenopus tropicalis (tropical clawed frog)	xrn2	XP_002939479.1
Homo sapiens (human)	XRN2	NP_036387.2
Bos taurus (cattle)	XRN2	NP_001179401.1
Mus musculus (house mouse)	Xrn2	NP_036047.2
Schizosaccharomyces pombe (fission yeast)	dhp1	NP_594155.1
Neurospora crassa	NCU01643	XP_956265.1
	XRN2	XP_001094734.2
Gallus gallus (chicken)	XRN2	NP_001026204.1
Danio rerio (zebrafish)	xrn2	NP_001001944.2
Magnaporthe oryzae (rice blast fungus)	MGG_11426	XP_003717803.1
Kluyveromyces lactis	KLLA0F07469g	XP_455419.1
Arabidopsis thaliana (thale cress)	XRN3	NP_565114.1
Oryza sativa (rice)	Os01g0872700	NP_001044947.1

Gene Ontology
Bibliography

Related articles in PubMed

XRN2 promotes EMT and metastasis through regulating maturation of miR-10a.
Zhang H, Lu Y, Chen E, Li X, Lv B, Vikis HG, Liu P
Oncogene36(27)3925-3933(2017 Jul)

The G-patch protein NF-?B-repressing factor mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis.
Memet I, Doebele C, Sloan KE, Bohnsack MT
Nucleic acids research45(9)5359-5374(2017 May)

XRN2 Links Transcription Termination to DNA Damage and Replication Stress.
Morales JC, Richard P, Patidar PL, Motea EA, Dang TT, Manley JL, Boothman DA
PLoS genetics12(7)e1006107(2016 07)

Structural basis and function of XRN2 binding by XTB domains.
Richter H, Katic I, Gut H, Gro?hans H
Nature structural & molecular biology23(2)164-71(2016 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

XRN2 is a novel regulator of EMT that contributes to the metastatic processes in lung cancer through a novel miRNA regulatory mechanism.
Title: XRN2 promotes EMT and metastasis through regulating maturation of miR-10a.

depletion of NKRF, XRN2 or DHX15 impairs an early pre-rRNA cleavage step.
Title: The G-patch protein NF-?B-repressing factor mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis.

XRN2 has a role in R-loop resolution, suppression of replication stress, and maintenance of genomic stability
Title: XRN2 Links Transcription Termination to DNA Damage and Replication Stress.

P-TEFb regulates termination by promoting chromatin recruitment and activation of a cotranscriptional RNA processing enzyme, Xrn2.
Title: P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates.

The results suggest that CARF regulates early steps of pre-rRNA processing during ribosome biogenesis by controlling spatial distribution of XRN2 between the nucleoplasm and nucleolus.
Title: Collaborator of alternative reading frame protein (CARF) regulates early processing of pre-ribosomal RNA by retaining XRN2 (5'-3' exoribonuclease) in the nucleoplasm.

The following XRN2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the XRN2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31060	NM_012255.5 Latest version!	Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
OHu92956	XM_017027724.1 Latest version!	Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant X3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$223.30 $319.00
OHu92954	XM_017027722.1 Latest version!	Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu92955	XM_017027723.2 Latest version!	Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu64947	NM_001317960.1 Latest version!	Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	20	$559.30 $799.00
View Old Accession Versions >>
OHu92955	XM_017027723.1	Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu31060	NM_012255.4	Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$339.50-$475.30 $679.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

XRN2 ( NM_012255.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_036387.2 Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu31060
Clone ID Related Accession (Same CDS sequence)	NM_012255.5 , NM_012255.4
Accession Version	NM_012255.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2853bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	5'-3' exoribonuclease 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC142960.1, AL136841.1 and AF152169.1. On Nov 23, 2018 this sequence version replaced NM_012255.4. Transcript Variant: This variant (2) contains an alternate 5' terminal exon, resulting in a distinct 5' UTR and the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus , and is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF152169.1, AK001573.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000377191.5/ ENSP00000366396.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGAGTCC CGGCGTTCTT CCGCTGGCTC AGCCGCAAGT ACCCGTCCAT CATAGTCAAC 
TGCGTGGAAG AGAAGCCAAA AGAATGCAAT GGTGTAAAGA TTCCAGTTGA TGCCAGTAAA 
CCTAATCCAA ATGATGTGGA GTTTGATAAT CTGTATTTGG ATATGAATGG AATCATCCAT 
CCCTGTACTC ATCCTGAAGA CAAACCAGCA CCAAAAAATG AAGATGAAAT GATGGTTGCA 
ATTTTTGAGT ACATTGACAG ACTTTTCAGT ATTGTAAGAC CAAGAAGACT TCTCTACATG 
GCAATAGATG GAGTGGCACC ACGTGCTAAA ATGAACCAGC AGCGTTCAAG GAGGTTCAGG 
GCATCAAAAG AAGGAATGGA AGCAGCAGTC GAGAAGCAGC GAGTCAGGGA AGAAATATTG 
GCAAAAGGTG GCTTTCTTCC TCCAGAAGAA ATAAAAGAAA GATTTGACAG CAACTGTATT 
ACACCAGGAA CTGAATTCAT GGACAATCTT GCTAAATGCC TTCGCTATTA CATAGCTGAT 
CGTTTAAATA ATGACCCTGG GTGGAAAAAT TTGACAGTTA TTTTATCTGA TGCTAGTGCT 
CCTGGTGAAG GAGAACATAA AATCATGGAT TACATTAGAA GGCAAAGAGC CCAGCCTAAC 
CATGACCCAA ATACTCATCA TTGTTTATGT GGAGCAGATG CTGATCTCAT TATGCTTGGC 
CTTGCCACAC ATGAACCGAA CTTTACCATT ATTAGAGAAG AATTCAAACC AAACAAGCCC 
AAACCATGTG GTCTTTGTAA TCAGTTTGGA CATGAGGTCA AAGATTGTGA AGGTTTGCCA 
AGAGAAAAGA AGGGAAAGCA TGATGAACTT GCCGATAGTC TTCCTTGTGC AGAAGGAGAG 
TTTATCTTCC TTCGGCTTAA TGTTCTTCGT GAGTATTTGG AAAGAGAACT CACAATGGCC 
AGCCTACCAT TCACATTTGA TGTTGAGAGG AGCATTGATG ACTGGGTTTT CATGTGCTTC 
TTTGTGGGAA ATGACTTCCT CCCTCATTTG CCATCGTTAG AGATTAGGGA AAATGCAATT 
GACCGTTTGG TTAACATATA CAAAAATGTG GTACACAAAA CTGGGGGTTA CCTTACAGAA 
AGTGGTTATG TCAATCTGCA AAGAGTACAG ATGATCATGT TAGCAGTTGG TGAAGTTGAG 
GATAGCATTT TTAAAAAGAG AAAGGATGAT GAGGACAGTT TTAGAAGACG ACAGAAAGAA 
AAAAGAAAGA GAATGAAGAG AGATCAACCA GCTTTCACTC CTAGTGGAAT ATTAACTCCT 
CATGCCTTGG GTTCAAGAAA TTCACCAGGT TCTCAAGTAG CCAGTAATCC GAGACAAGCA 
GCCTATGAAA TGAGGATGCA GAATAACTCT AGTCCTTCGA TATCTCCTAA TACGAGTTTC 
ACATCTGATG GCTCCCCGTC TCCATTAGGA GGAATTAAGC GAAAAGCAGA AGACAGTGAC 
AGTGAACCTG AGCCAGAGGA TAATGTCAGG TTATGGGAAG CTGGCTGGAA GCAGCGGTAC 
TACAAGAACA AATTTGATGT GGATGCAGCT GATGAGAAAT TCCGTCGGAA AGTTGTGCAG 
TCGTACGTTG AAGGACTTTG CTGGGTTCTT AGATATTATT ACCAGGGCTG TGCTTCCTGG 
AAGTGGTATT ATCCATTTCA TTATGCACCA TTTGCTTCAG ACTTTGAAGG CATTGCAGAC 
ATGCCATCTG ATTTTGAGAA GGGTACGAAA CCGTTTAAAC CACTAGAACA ACTTATGGGG 
GTATTTCCAG CTGCAAGTGG TAATTTTCTA CCTCCATCAT GGCGGAAGCT CATGAGTGAT 
CCTGATTCTA GTATAATTGA CTTCTATCCT GAAGATTTTG CTATTGATTT GAATGGGAAG 
AAATATGCAT GGCAAGGTGT TGCTCTCTTG CCATTCGTGG ATGAGCGAAG GCTACGAGCT 
GCCCTAGAAG AGGTATACCC AGACCTCACT CCAGAAGAGA CCAGAAGAAA CAGCCTTGGA 
GGTGATGTCT TATTTGTGGG GAAACATCAC CCACTCCATG ACTTCATTTT AGAGCTGTAC 
CAGACAGGTT CCACAGAGCC AGTGGAGGTA CCCCCTGAAC TATGTCATGG GATTCAAGGA 
AAGTTTTCTT TGGATGAAGA AGCCATTCTT CCAGATCAAA TAGTATGTTC TCCTGTTCCT 
ATGTTAAGGG ATCTGACACA GAACACTGTA GTCAGTATTA ATTTTAAAGA CCCACAGTTT 
GCTGAAGATT ACATTTTTAA AGCTGTAATG CTTCCAGGAG CAAGAAAGCC AGCAGCAGTA 
CTGAAACCTA GTGACTGGGA AAAATCCAGC AATGGACGGC AGTGGAAGCC TCAGCTTGGC 
TTTAACCGTG ACCGGAGGCC TGTGCACCTG GATCAGGCAG CCTTCAGGAC TTTGGGCCAT 
GTGATGCCAA GAGGCTCAGG AACTGGCATT TACAGCAATG CTGCACCACC ACCTGTGACT 
TACCAGGGAA ACTTATACAG GCCGCTTTTG AGAGGACAAG CCCAGATTCC AAAACTTATG 
TCAAATATGA GGCCCCAGGA TTCCTGGCGA GGTCCTCCTC CCCTTTTCCA GCAGCAAAGG 
TTTGACAGAG GCGTTGGGGC TGAACCTCTG CTCCCATGGA ACCGGATGCT GCAAACCCAG 
AATGCAGCCT TCCAGCCAAA CCAGTACCAG ATGCTAGCTG GGCCTGGTGG GTATCCACCC 
AGACGAGATG ATCGTGGAGG GAGACAGGGA TATCCCAGAG AAGGAAGGAA ATACCCTTTG 
CCACCACCCT CAGGAAGATA CAATTGGAAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036387.2
CDS	69..2921
Translation	MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTYQGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDRGGRQGYPREGRKYPLPPPSGRYNWN

Target ORF information:

RefSeq Version	NM_012255.5
Organism	Homo sapiens(human)
Definition	Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012255.5

ORF Insert Sequence:

ATGGGAGTCC CGGCGTTCTT CCGCTGGCTC AGCCGCAAGT ACCCGTCCAT CATAGTCAAC 
TGCGTGGAAG AGAAGCCAAA AGAATGCAAT GGTGTAAAGA TTCCAGTTGA TGCCAGTAAA 
CCTAATCCAA ATGATGTGGA GTTTGATAAT CTGTATTTGG ATATGAATGG AATCATCCAT 
CCCTGTACTC ATCCTGAAGA CAAACCAGCA CCAAAAAATG AAGATGAAAT GATGGTTGCA 
ATTTTTGAGT ACATTGACAG ACTTTTCAGT ATTGTAAGAC CAAGAAGACT TCTCTACATG 
GCAATAGATG GAGTGGCACC ACGTGCTAAA ATGAACCAGC AGCGTTCAAG GAGGTTCAGG 
GCATCAAAAG AAGGAATGGA AGCAGCAGTC GAGAAGCAGC GAGTCAGGGA AGAAATATTG 
GCAAAAGGTG GCTTTCTTCC TCCAGAAGAA ATAAAAGAAA GATTTGACAG CAACTGTATT 
ACACCAGGAA CTGAATTCAT GGACAATCTT GCTAAATGCC TTCGCTATTA CATAGCTGAT 
CGTTTAAATA ATGACCCTGG GTGGAAAAAT TTGACAGTTA TTTTATCTGA TGCTAGTGCT 
CCTGGTGAAG GAGAACATAA AATCATGGAT TACATTAGAA GGCAAAGAGC CCAGCCTAAC 
CATGACCCAA ATACTCATCA TTGTTTATGT GGAGCAGATG CTGATCTCAT TATGCTTGGC 
CTTGCCACAC ATGAACCGAA CTTTACCATT ATTAGAGAAG AATTCAAACC AAACAAGCCC 
AAACCATGTG GTCTTTGTAA TCAGTTTGGA CATGAGGTCA AAGATTGTGA AGGTTTGCCA 
AGAGAAAAGA AGGGAAAGCA TGATGAACTT GCCGATAGTC TTCCTTGTGC AGAAGGAGAG 
TTTATCTTCC TTCGGCTTAA TGTTCTTCGT GAGTATTTGG AAAGAGAACT CACAATGGCC 
AGCCTACCAT TCACATTTGA TGTTGAGAGG AGCATTGATG ACTGGGTTTT CATGTGCTTC 
TTTGTGGGAA ATGACTTCCT CCCTCATTTG CCATCGTTAG AGATTAGGGA AAATGCAATT 
GACCGTTTGG TTAACATATA CAAAAATGTG GTACACAAAA CTGGGGGTTA CCTTACAGAA 
AGTGGTTATG TCAATCTGCA AAGAGTACAG ATGATCATGT TAGCAGTTGG TGAAGTTGAG 
GATAGCATTT TTAAAAAGAG AAAGGATGAT GAGGACAGTT TTAGAAGACG ACAGAAAGAA 
AAAAGAAAGA GAATGAAGAG AGATCAACCA GCTTTCACTC CTAGTGGAAT ATTAACTCCT 
CATGCCTTGG GTTCAAGAAA TTCACCAGGT TCTCAAGTAG CCAGTAATCC GAGACAAGCA 
GCCTATGAAA TGAGGATGCA GAATAACTCT AGTCCTTCGA TATCTCCTAA TACGAGTTTC 
ACATCTGATG GCTCCCCGTC TCCATTAGGA GGAATTAAGC GAAAAGCAGA AGACAGTGAC 
AGTGAACCTG AGCCAGAGGA TAATGTCAGG TTATGGGAAG CTGGCTGGAA GCAGCGGTAC 
TACAAGAACA AATTTGATGT GGATGCAGCT GATGAGAAAT TCCGTCGGAA AGTTGTGCAG 
TCGTACGTTG AAGGACTTTG CTGGGTTCTT AGATATTATT ACCAGGGCTG TGCTTCCTGG 
AAGTGGTATT ATCCATTTCA TTATGCACCA TTTGCTTCAG ACTTTGAAGG CATTGCAGAC 
ATGCCATCTG ATTTTGAGAA GGGTACGAAA CCGTTTAAAC CACTAGAACA ACTTATGGGG 
GTATTTCCAG CTGCAAGTGG TAATTTTCTA CCTCCATCAT GGCGGAAGCT CATGAGTGAT 
CCTGATTCTA GTATAATTGA CTTCTATCCT GAAGATTTTG CTATTGATTT GAATGGGAAG 
AAATATGCAT GGCAAGGTGT TGCTCTCTTG CCATTCGTGG ATGAGCGAAG GCTACGAGCT 
GCCCTAGAAG AGGTATACCC AGACCTCACT CCAGAAGAGA CCAGAAGAAA CAGCCTTGGA 
GGTGATGTCT TATTTGTGGG GAAACATCAC CCACTCCATG ACTTCATTTT AGAGCTGTAC 
CAGACAGGTT CCACAGAGCC AGTGGAGGTA CCCCCTGAAC TATGTCATGG GATTCAAGGA 
AAGTTTTCTT TGGATGAAGA AGCCATTCTT CCAGATCAAA TAGTATGTTC TCCTGTTCCT 
ATGTTAAGGG ATCTGACACA GAACACTGTA GTCAGTATTA ATTTTAAAGA CCCACAGTTT 
GCTGAAGATT ACATTTTTAA AGCTGTAATG CTTCCAGGAG CAAGAAAGCC AGCAGCAGTA 
CTGAAACCTA GTGACTGGGA AAAATCCAGC AATGGACGGC AGTGGAAGCC TCAGCTTGGC 
TTTAACCGTG ACCGGAGGCC TGTGCACCTG GATCAGGCAG CCTTCAGGAC TTTGGGCCAT 
GTGATGCCAA GAGGCTCAGG AACTGGCATT TACAGCAATG CTGCACCACC ACCTGTGACT 
TACCAGGGAA ACTTATACAG GCCGCTTTTG AGAGGACAAG CCCAGATTCC AAAACTTATG 
TCAAATATGA GGCCCCAGGA TTCCTGGCGA GGTCCTCCTC CCCTTTTCCA GCAGCAAAGG 
TTTGACAGAG GCGTTGGGGC TGAACCTCTG CTCCCATGGA ACCGGATGCT GCAAACCCAG 
AATGCAGCCT TCCAGCCAAA CCAGTACCAG ATGCTAGCTG GGCCTGGTGG GTATCCACCC 
AGACGAGATG ATCGTGGAGG GAGACAGGGA TATCCCAGAG AAGGAAGGAA ATACCCTTTG 
CCACCACCCT CAGGAAGATA CAATTGGAAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

XRN2 ( NM_012255.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_036387.2 Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu31060
Clone ID Related Accession (Same CDS sequence)	NM_012255.5 , NM_012255.4
Accession Version	NM_012255.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2853bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	5'-3' exoribonuclease 2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC142960.1, AL136841.1 and AF152169.1. On Dec 17, 2015 this sequence version replaced NM_012255.3. Transcript Variant: This variant (2) contains an alternate 5' terminal exon, resulting in a distinct 5' UTR and the use of an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus , and is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AF152169.1, SRR1660805.181886.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGTCC CGGCGTTCTT CCGCTGGCTC AGCCGCAAGT ACCCGTCCAT CATAGTCAAC 
TGCGTGGAAG AGAAGCCAAA AGAATGCAAT GGTGTAAAGA TTCCAGTTGA TGCCAGTAAA 
CCTAATCCAA ATGATGTGGA GTTTGATAAT CTGTATTTGG ATATGAATGG AATCATCCAT 
CCCTGTACTC ATCCTGAAGA CAAACCAGCA CCAAAAAATG AAGATGAAAT GATGGTTGCA 
ATTTTTGAGT ACATTGACAG ACTTTTCAGT ATTGTAAGAC CAAGAAGACT TCTCTACATG 
GCAATAGATG GAGTGGCACC ACGTGCTAAA ATGAACCAGC AGCGTTCAAG GAGGTTCAGG 
GCATCAAAAG AAGGAATGGA AGCAGCAGTC GAGAAGCAGC GAGTCAGGGA AGAAATATTG 
GCAAAAGGTG GCTTTCTTCC TCCAGAAGAA ATAAAAGAAA GATTTGACAG CAACTGTATT 
ACACCAGGAA CTGAATTCAT GGACAATCTT GCTAAATGCC TTCGCTATTA CATAGCTGAT 
CGTTTAAATA ATGACCCTGG GTGGAAAAAT TTGACAGTTA TTTTATCTGA TGCTAGTGCT 
CCTGGTGAAG GAGAACATAA AATCATGGAT TACATTAGAA GGCAAAGAGC CCAGCCTAAC 
CATGACCCAA ATACTCATCA TTGTTTATGT GGAGCAGATG CTGATCTCAT TATGCTTGGC 
CTTGCCACAC ATGAACCGAA CTTTACCATT ATTAGAGAAG AATTCAAACC AAACAAGCCC 
AAACCATGTG GTCTTTGTAA TCAGTTTGGA CATGAGGTCA AAGATTGTGA AGGTTTGCCA 
AGAGAAAAGA AGGGAAAGCA TGATGAACTT GCCGATAGTC TTCCTTGTGC AGAAGGAGAG 
TTTATCTTCC TTCGGCTTAA TGTTCTTCGT GAGTATTTGG AAAGAGAACT CACAATGGCC 
AGCCTACCAT TCACATTTGA TGTTGAGAGG AGCATTGATG ACTGGGTTTT CATGTGCTTC 
TTTGTGGGAA ATGACTTCCT CCCTCATTTG CCATCGTTAG AGATTAGGGA AAATGCAATT 
GACCGTTTGG TTAACATATA CAAAAATGTG GTACACAAAA CTGGGGGTTA CCTTACAGAA 
AGTGGTTATG TCAATCTGCA AAGAGTACAG ATGATCATGT TAGCAGTTGG TGAAGTTGAG 
GATAGCATTT TTAAAAAGAG AAAGGATGAT GAGGACAGTT TTAGAAGACG ACAGAAAGAA 
AAAAGAAAGA GAATGAAGAG AGATCAACCA GCTTTCACTC CTAGTGGAAT ATTAACTCCT 
CATGCCTTGG GTTCAAGAAA TTCACCAGGT TCTCAAGTAG CCAGTAATCC GAGACAAGCA 
GCCTATGAAA TGAGGATGCA GAATAACTCT AGTCCTTCGA TATCTCCTAA TACGAGTTTC 
ACATCTGATG GCTCCCCGTC TCCATTAGGA GGAATTAAGC GAAAAGCAGA AGACAGTGAC 
AGTGAACCTG AGCCAGAGGA TAATGTCAGG TTATGGGAAG CTGGCTGGAA GCAGCGGTAC 
TACAAGAACA AATTTGATGT GGATGCAGCT GATGAGAAAT TCCGTCGGAA AGTTGTGCAG 
TCGTACGTTG AAGGACTTTG CTGGGTTCTT AGATATTATT ACCAGGGCTG TGCTTCCTGG 
AAGTGGTATT ATCCATTTCA TTATGCACCA TTTGCTTCAG ACTTTGAAGG CATTGCAGAC 
ATGCCATCTG ATTTTGAGAA GGGTACGAAA CCGTTTAAAC CACTAGAACA ACTTATGGGG 
GTATTTCCAG CTGCAAGTGG TAATTTTCTA CCTCCATCAT GGCGGAAGCT CATGAGTGAT 
CCTGATTCTA GTATAATTGA CTTCTATCCT GAAGATTTTG CTATTGATTT GAATGGGAAG 
AAATATGCAT GGCAAGGTGT TGCTCTCTTG CCATTCGTGG ATGAGCGAAG GCTACGAGCT 
GCCCTAGAAG AGGTATACCC AGACCTCACT CCAGAAGAGA CCAGAAGAAA CAGCCTTGGA 
GGTGATGTCT TATTTGTGGG GAAACATCAC CCACTCCATG ACTTCATTTT AGAGCTGTAC 
CAGACAGGTT CCACAGAGCC AGTGGAGGTA CCCCCTGAAC TATGTCATGG GATTCAAGGA 
AAGTTTTCTT TGGATGAAGA AGCCATTCTT CCAGATCAAA TAGTATGTTC TCCTGTTCCT 
ATGTTAAGGG ATCTGACACA GAACACTGTA GTCAGTATTA ATTTTAAAGA CCCACAGTTT 
GCTGAAGATT ACATTTTTAA AGCTGTAATG CTTCCAGGAG CAAGAAAGCC AGCAGCAGTA 
CTGAAACCTA GTGACTGGGA AAAATCCAGC AATGGACGGC AGTGGAAGCC TCAGCTTGGC 
TTTAACCGTG ACCGGAGGCC TGTGCACCTG GATCAGGCAG CCTTCAGGAC TTTGGGCCAT 
GTGATGCCAA GAGGCTCAGG AACTGGCATT TACAGCAATG CTGCACCACC ACCTGTGACT 
TACCAGGGAA ACTTATACAG GCCGCTTTTG AGAGGACAAG CCCAGATTCC AAAACTTATG 
TCAAATATGA GGCCCCAGGA TTCCTGGCGA GGTCCTCCTC CCCTTTTCCA GCAGCAAAGG 
TTTGACAGAG GCGTTGGGGC TGAACCTCTG CTCCCATGGA ACCGGATGCT GCAAACCCAG 
AATGCAGCCT TCCAGCCAAA CCAGTACCAG ATGCTAGCTG GGCCTGGTGG GTATCCACCC 
AGACGAGATG ATCGTGGAGG GAGACAGGGA TATCCCAGAG AAGGAAGGAA ATACCCTTTG 
CCACCACCCT CAGGAAGATA CAATTGGAAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_036387.2
CDS	116..2968
Translation	MGVPAFFRWLSRKYPSIIVNCVEEKPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTYQGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDRGGRQGYPREGRKYPLPPPSGRYNWN

Target ORF information:

RefSeq Version	NM_012255.4
Organism	Homo sapiens(human)
Definition	Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_012255.4

ORF Insert Sequence:

ATGGGAGTCC CGGCGTTCTT CCGCTGGCTC AGCCGCAAGT ACCCGTCCAT CATAGTCAAC 
TGCGTGGAAG AGAAGCCAAA AGAATGCAAT GGTGTAAAGA TTCCAGTTGA TGCCAGTAAA 
CCTAATCCAA ATGATGTGGA GTTTGATAAT CTGTATTTGG ATATGAATGG AATCATCCAT 
CCCTGTACTC ATCCTGAAGA CAAACCAGCA CCAAAAAATG AAGATGAAAT GATGGTTGCA 
ATTTTTGAGT ACATTGACAG ACTTTTCAGT ATTGTAAGAC CAAGAAGACT TCTCTACATG 
GCAATAGATG GAGTGGCACC ACGTGCTAAA ATGAACCAGC AGCGTTCAAG GAGGTTCAGG 
GCATCAAAAG AAGGAATGGA AGCAGCAGTC GAGAAGCAGC GAGTCAGGGA AGAAATATTG 
GCAAAAGGTG GCTTTCTTCC TCCAGAAGAA ATAAAAGAAA GATTTGACAG CAACTGTATT 
ACACCAGGAA CTGAATTCAT GGACAATCTT GCTAAATGCC TTCGCTATTA CATAGCTGAT 
CGTTTAAATA ATGACCCTGG GTGGAAAAAT TTGACAGTTA TTTTATCTGA TGCTAGTGCT 
CCTGGTGAAG GAGAACATAA AATCATGGAT TACATTAGAA GGCAAAGAGC CCAGCCTAAC 
CATGACCCAA ATACTCATCA TTGTTTATGT GGAGCAGATG CTGATCTCAT TATGCTTGGC 
CTTGCCACAC ATGAACCGAA CTTTACCATT ATTAGAGAAG AATTCAAACC AAACAAGCCC 
AAACCATGTG GTCTTTGTAA TCAGTTTGGA CATGAGGTCA AAGATTGTGA AGGTTTGCCA 
AGAGAAAAGA AGGGAAAGCA TGATGAACTT GCCGATAGTC TTCCTTGTGC AGAAGGAGAG 
TTTATCTTCC TTCGGCTTAA TGTTCTTCGT GAGTATTTGG AAAGAGAACT CACAATGGCC 
AGCCTACCAT TCACATTTGA TGTTGAGAGG AGCATTGATG ACTGGGTTTT CATGTGCTTC 
TTTGTGGGAA ATGACTTCCT CCCTCATTTG CCATCGTTAG AGATTAGGGA AAATGCAATT 
GACCGTTTGG TTAACATATA CAAAAATGTG GTACACAAAA CTGGGGGTTA CCTTACAGAA 
AGTGGTTATG TCAATCTGCA AAGAGTACAG ATGATCATGT TAGCAGTTGG TGAAGTTGAG 
GATAGCATTT TTAAAAAGAG AAAGGATGAT GAGGACAGTT TTAGAAGACG ACAGAAAGAA 
AAAAGAAAGA GAATGAAGAG AGATCAACCA GCTTTCACTC CTAGTGGAAT ATTAACTCCT 
CATGCCTTGG GTTCAAGAAA TTCACCAGGT TCTCAAGTAG CCAGTAATCC GAGACAAGCA 
GCCTATGAAA TGAGGATGCA GAATAACTCT AGTCCTTCGA TATCTCCTAA TACGAGTTTC 
ACATCTGATG GCTCCCCGTC TCCATTAGGA GGAATTAAGC GAAAAGCAGA AGACAGTGAC 
AGTGAACCTG AGCCAGAGGA TAATGTCAGG TTATGGGAAG CTGGCTGGAA GCAGCGGTAC 
TACAAGAACA AATTTGATGT GGATGCAGCT GATGAGAAAT TCCGTCGGAA AGTTGTGCAG 
TCGTACGTTG AAGGACTTTG CTGGGTTCTT AGATATTATT ACCAGGGCTG TGCTTCCTGG 
AAGTGGTATT ATCCATTTCA TTATGCACCA TTTGCTTCAG ACTTTGAAGG CATTGCAGAC 
ATGCCATCTG ATTTTGAGAA GGGTACGAAA CCGTTTAAAC CACTAGAACA ACTTATGGGG 
GTATTTCCAG CTGCAAGTGG TAATTTTCTA CCTCCATCAT GGCGGAAGCT CATGAGTGAT 
CCTGATTCTA GTATAATTGA CTTCTATCCT GAAGATTTTG CTATTGATTT GAATGGGAAG 
AAATATGCAT GGCAAGGTGT TGCTCTCTTG CCATTCGTGG ATGAGCGAAG GCTACGAGCT 
GCCCTAGAAG AGGTATACCC AGACCTCACT CCAGAAGAGA CCAGAAGAAA CAGCCTTGGA 
GGTGATGTCT TATTTGTGGG GAAACATCAC CCACTCCATG ACTTCATTTT AGAGCTGTAC 
CAGACAGGTT CCACAGAGCC AGTGGAGGTA CCCCCTGAAC TATGTCATGG GATTCAAGGA 
AAGTTTTCTT TGGATGAAGA AGCCATTCTT CCAGATCAAA TAGTATGTTC TCCTGTTCCT 
ATGTTAAGGG ATCTGACACA GAACACTGTA GTCAGTATTA ATTTTAAAGA CCCACAGTTT 
GCTGAAGATT ACATTTTTAA AGCTGTAATG CTTCCAGGAG CAAGAAAGCC AGCAGCAGTA 
CTGAAACCTA GTGACTGGGA AAAATCCAGC AATGGACGGC AGTGGAAGCC TCAGCTTGGC 
TTTAACCGTG ACCGGAGGCC TGTGCACCTG GATCAGGCAG CCTTCAGGAC TTTGGGCCAT 
GTGATGCCAA GAGGCTCAGG AACTGGCATT TACAGCAATG CTGCACCACC ACCTGTGACT 
TACCAGGGAA ACTTATACAG GCCGCTTTTG AGAGGACAAG CCCAGATTCC AAAACTTATG 
TCAAATATGA GGCCCCAGGA TTCCTGGCGA GGTCCTCCTC CCCTTTTCCA GCAGCAAAGG 
TTTGACAGAG GCGTTGGGGC TGAACCTCTG CTCCCATGGA ACCGGATGCT GCAAACCCAG 
AATGCAGCCT TCCAGCCAAA CCAGTACCAG ATGCTAGCTG GGCCTGGTGG GTATCCACCC 
AGACGAGATG ATCGTGGAGG GAGACAGGGA TATCCCAGAG AAGGAAGGAA ATACCCTTTG 
CCACCACCCT CAGGAAGATA CAATTGGAAT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

XRN2 ( XM_017027724.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883213.1 Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant X3, mRNA.

Price & Availability↑

CloneID	OHu92956
Clone ID Related Accession (Same CDS sequence)	XM_017027724.1
Accession Version	XM_017027724.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1491bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	5'-3' exoribonuclease 2 isoform X3
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTCCG CCGCCTGCCC CCGGGGAGCC TTGCCGGAGC TCGCGCCCTG CTGCCAGCCT 
CGCGAGCAGT CGCAGCCCCA CACGCGATGG GACGCGGGCT GTGGGATTCA GCACCCCGGG 
GGCGAGGAAT TCAGGACCCT CGGCGGGGCA AGGGCCTATA GGGTTCCGAA CTCGCAGGAG 
GGTCGCTCCT CCCCTACTCG CTTTTTCCCG GCACCGGAAG GCCCCGCCCA CTGCTTTGTT 
TCCTCTCCAG ACCGCGCATT TTGGGTCTCG GAAGAGGTTC AGAGGCTGTT GTTGAGCAAT 
GCATGCCAGC CAAAAGAATG CAATGGTGTA AAGATTCCAG TTGATGCCAG TAAACCTAAT 
CCAAATGATG TGGAGTTTGA TAATCTGTAT TTGGATATGA ATGGAATCAT CCATCCCTGT 
ACTCATCCTG AAGACAAACC AGCACCAAAA AATGAAGATG AAATGATGGT TGCAATTTTT 
GAGTACATTG ACAGACTTTT CAGTATTGTA AGACCAAGAA GACTTCTCTA CATGGCAATA 
GATGGAGTGG CACCACGTGC TAAAATGAAC CAGCAGCGTT CAAGGAGGTT CAGGGCATCA 
AAAGAAGGAA TGGAAGCAGC AGTCGAGAAG CAGCGAGTCA GGGAAGAAAT ATTGGCAAAA 
GGTGGCTTTC TTCCTCCAGA AGAAATAAAA GAAAGATTTG ACAGCAACTG TATTACACCA 
GGAACTGAAT TCATGGACAA TCTTGCTAAA TGCCTTCGCT ATTACATAGC TGATCGTTTA 
AATAATGACC CTGGGTGGAA AAATTTGACA GTTATTTTAT CTGATGCTAG TGCTCCTGGT 
GAAGGAGAAC ATAAAATCAT GGATTACATT AGAAGGCAAA GAGCCCAGCC TAACCATGAC 
CCAAATACTC ATCATTGTTT ATGTGGAGCA GATGCTGATC TCATTATGCT TGGCCTTGCC 
ACACATGAAC CGAACTTTAC CATTATTAGA GAAGAATTCA AACCAAACAA GCCCAAACCA 
TGTGGTCTTT GTAATCAGTT TGGACATGAG GTCAAAGATT GTGAAGGTTT GCCAAGAGAA 
AAGAAGGGAA AGCATGATGA ACTTGCCGAT AGTCTTCCTT GTGCAGAAGG AGAGTTTATC 
TTCCTTCGGC TTAATGTTCT TCGTGAGTAT TTGGAAAGAG AACTCACAAT GGCCAGCCTA 
CCATTCACAT TTGATGTTGA GAGGAGCATT GATGACTGGG TTTTCATGTG CTTCTTTGTG 
GGAAATGACT TCCTCCCTCA TTTGCCATCG TTAGAGATTA GGGAAAATGC AATTGACCGT 
TTGGTTAACA TATACAAAAA TGTGGTACAC AAAACTGGGG GTTACCTTAC AGAAAGTGGT 
TATGTCAATC TGCAAAGAGT ACAGATGATC ATGTTAGCAG TTGGTGAAGT TGAGGATAGC 
ATTTTTAAAA AGAGAAAGGA TGATGAGAAT ATGTGGATTT TATACTTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883213.1
CDS	37..1527
Translation	MGSAACPRGALPELAPCCQPREQSQPHTRWDAGCGIQHPGGEEFRTLGGARAYRVPNSQEGRSSPTRFFPAPEGPAHCFVSSPDRAFWVSEEVQRLLLSNACQPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDENMWILYF

Target ORF information:

RefSeq Version	XM_017027724.1
Organism	Homo sapiens(human)
Definition	Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant X3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027724.1

ORF Insert Sequence:

ATGGGCTCCG CCGCCTGCCC CCGGGGAGCC TTGCCGGAGC TCGCGCCCTG CTGCCAGCCT 
CGCGAGCAGT CGCAGCCCCA CACGCGATGG GACGCGGGCT GTGGGATTCA GCACCCCGGG 
GGCGAGGAAT TCAGGACCCT CGGCGGGGCA AGGGCCTATA GGGTTCCGAA CTCGCAGGAG 
GGTCGCTCCT CCCCTACTCG CTTTTTCCCG GCACCGGAAG GCCCCGCCCA CTGCTTTGTT 
TCCTCTCCAG ACCGCGCATT TTGGGTCTCG GAAGAGGTTC AGAGGCTGTT GTTGAGCAAT 
GCATGCCAGC CAAAAGAATG CAATGGTGTA AAGATTCCAG TTGATGCCAG TAAACCTAAT 
CCAAATGATG TGGAGTTTGA TAATCTGTAT TTGGATATGA ATGGAATCAT CCATCCCTGT 
ACTCATCCTG AAGACAAACC AGCACCAAAA AATGAAGATG AAATGATGGT TGCAATTTTT 
GAGTACATTG ACAGACTTTT CAGTATTGTA AGACCAAGAA GACTTCTCTA CATGGCAATA 
GATGGAGTGG CACCACGTGC TAAAATGAAC CAGCAGCGTT CAAGGAGGTT CAGGGCATCA 
AAAGAAGGAA TGGAAGCAGC AGTCGAGAAG CAGCGAGTCA GGGAAGAAAT ATTGGCAAAA 
GGTGGCTTTC TTCCTCCAGA AGAAATAAAA GAAAGATTTG ACAGCAACTG TATTACACCA 
GGAACTGAAT TCATGGACAA TCTTGCTAAA TGCCTTCGCT ATTACATAGC TGATCGTTTA 
AATAATGACC CTGGGTGGAA AAATTTGACA GTTATTTTAT CTGATGCTAG TGCTCCTGGT 
GAAGGAGAAC ATAAAATCAT GGATTACATT AGAAGGCAAA GAGCCCAGCC TAACCATGAC 
CCAAATACTC ATCATTGTTT ATGTGGAGCA GATGCTGATC TCATTATGCT TGGCCTTGCC 
ACACATGAAC CGAACTTTAC CATTATTAGA GAAGAATTCA AACCAAACAA GCCCAAACCA 
TGTGGTCTTT GTAATCAGTT TGGACATGAG GTCAAAGATT GTGAAGGTTT GCCAAGAGAA 
AAGAAGGGAA AGCATGATGA ACTTGCCGAT AGTCTTCCTT GTGCAGAAGG AGAGTTTATC 
TTCCTTCGGC TTAATGTTCT TCGTGAGTAT TTGGAAAGAG AACTCACAAT GGCCAGCCTA 
CCATTCACAT TTGATGTTGA GAGGAGCATT GATGACTGGG TTTTCATGTG CTTCTTTGTG 
GGAAATGACT TCCTCCCTCA TTTGCCATCG TTAGAGATTA GGGAAAATGC AATTGACCGT 
TTGGTTAACA TATACAAAAA TGTGGTACAC AAAACTGGGG GTTACCTTAC AGAAAGTGGT 
TATGTCAATC TGCAAAGAGT ACAGATGATC ATGTTAGCAG TTGGTGAAGT TGAGGATAGC 
ATTTTTAAAA AGAGAAAGGA TGATGAGAAT ATGTGGATTT TATACTTTTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

XRN2 ( XM_017027722.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883211.1 Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu92954
Clone ID Related Accession (Same CDS sequence)	XM_017027722.1
Accession Version	XM_017027722.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1812bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	5'-3' exoribonuclease 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGCTCCG CCGCCTGCCC CCGGGGAGCC TTGCCGGAGC TCGCGCCCTG CTGCCAGCCT 
CGCGAGCAGT CGCAGCCCCA CACGCGATGG GACGCGGGCT GTGGGATTCA GCACCCCGGG 
GGCGAGGAAT TCAGGACCCT CGGCGGGGCA AGGGCCTATA GGGTTCCGAA CTCGCAGGAG 
GGTCGCTCCT CCCCTACTCG CTTTTTCCCG GCACCGGAAG GCCCCGCCCA CTGCTTTGTT 
TCCTCTCCAG ACCGCGCATT TTGGGTCTCG GAAGAGGTTC AGAGGCTGTT GTTGAGCAAT 
GCATGCCAGC CAAAAGAATG CAATGGTGTA AAGATTCCAG TTGATGCCAG TAAACCTAAT 
CCAAATGATG TGGAGTTTGA TAATCTGTAT TTGGATATGA ATGGAATCAT CCATCCCTGT 
ACTCATCCTG AAGACAAACC AGCACCAAAA AATGAAGATG AAATGATGGT TGCAATTTTT 
GAGTACATTG ACAGACTTTT CAGTATTGTA AGACCAAGAA GACTTCTCTA CATGGCAATA 
GATGGAGTGG CACCACGTGC TAAAATGAAC CAGCAGCGTT CAAGGAGGTT CAGGGCATCA 
AAAGAAGGAA TGGAAGCAGC AGTCGAGAAG CAGCGAGTCA GGGAAGAAAT ATTGGCAAAA 
GGTGGCTTTC TTCCTCCAGA AGAAATAAAA GAAAGATTTG ACAGCAACTG TATTACACCA 
GGAACTGAAT TCATGGACAA TCTTGCTAAA TGCCTTCGCT ATTACATAGC TGATCGTTTA 
AATAATGACC CTGGGTGGAA AAATTTGACA GTTATTTTAT CTGATGCTAG TGCTCCTGGT 
GAAGGAGAAC ATAAAATCAT GGATTACATT AGAAGGCAAA GAGCCCAGCC TAACCATGAC 
CCAAATACTC ATCATTGTTT ATGTGGAGCA GATGCTGATC TCATTATGCT TGGCCTTGCC 
ACACATGAAC CGAACTTTAC CATTATTAGA GAAGAATTCA AACCAAACAA GCCCAAACCA 
TGTGGTCTTT GTAATCAGTT TGGACATGAG GTCAAAGATT GTGAAGGTTT GCCAAGAGAA 
AAGAAGGGAA AGCATGATGA ACTTGCCGAT AGTCTTCCTT GTGCAGAAGG AGAGTTTATC 
TTCCTTCGGC TTAATGTTCT TCGTGAGTAT TTGGAAAGAG AACTCACAAT GGCCAGCCTA 
CCATTCACAT TTGATGTTGA GAGGAGCATT GATGACTGGG TTTTCATGTG CTTCTTTGTG 
GGAAATGACT TCCTCCCTCA TTTGCCATCG TTAGAGATTA GGGAAAATGC AATTGACCGT 
TTGGTTAACA TATACAAAAA TGTGGTACAC AAAACTGGGG GTTACCTTAC AGAAAGTGGT 
TATGTCAATC TGCAAAGAGT ACAGATGATC ATGTTAGCAG TTGGTGAAGT TGAGGATAGC 
ATTTTTAAAA AGAGAAAGGA TGATGAGGAC AGTTTTAGAA GACGACAGAA AGAAAAAAGA 
AAGAGAATGA AGAGAGATCA ACCAGCTTTC ACTCCTAGTG GAATATTAAC TCCTCATGCC 
TTGGGTTCAA GAAATTCACC AGGTTCTCAA GTAGCCAGTA ATCCGAGACA AGCAGCCTAT 
GAAATGAGGA TGCAGAATAA CTCTAGTCCT TCGATATCTC CTAATACGAG TTTCACATCT 
GATGGCTCCC CGTCTCCATT AGGAGGAATT AAGCGAAAAG CAGAAGACAG TGACAGTGAA 
CCTGAGCCAG AGGATAATGT CAGCCATCAA CAACTCTTAG CTGAAAGAGG GATAAGGCCC 
AAGCAAGGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883211.1
CDS	37..1848
Translation	MGSAACPRGALPELAPCCQPREQSQPHTRWDAGCGIQHPGGEEFRTLGGARAYRVPNSQEGRSSPTRFFPAPEGPAHCFVSSPDRAFWVSEEVQRLLLSNACQPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSDSEPEPEDNVSHQQLLAERGIRPKQG

Target ORF information:

RefSeq Version	XM_017027722.1
Organism	Homo sapiens(human)
Definition	Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027722.1

ORF Insert Sequence:

ATGGGCTCCG CCGCCTGCCC CCGGGGAGCC TTGCCGGAGC TCGCGCCCTG CTGCCAGCCT 
CGCGAGCAGT CGCAGCCCCA CACGCGATGG GACGCGGGCT GTGGGATTCA GCACCCCGGG 
GGCGAGGAAT TCAGGACCCT CGGCGGGGCA AGGGCCTATA GGGTTCCGAA CTCGCAGGAG 
GGTCGCTCCT CCCCTACTCG CTTTTTCCCG GCACCGGAAG GCCCCGCCCA CTGCTTTGTT 
TCCTCTCCAG ACCGCGCATT TTGGGTCTCG GAAGAGGTTC AGAGGCTGTT GTTGAGCAAT 
GCATGCCAGC CAAAAGAATG CAATGGTGTA AAGATTCCAG TTGATGCCAG TAAACCTAAT 
CCAAATGATG TGGAGTTTGA TAATCTGTAT TTGGATATGA ATGGAATCAT CCATCCCTGT 
ACTCATCCTG AAGACAAACC AGCACCAAAA AATGAAGATG AAATGATGGT TGCAATTTTT 
GAGTACATTG ACAGACTTTT CAGTATTGTA AGACCAAGAA GACTTCTCTA CATGGCAATA 
GATGGAGTGG CACCACGTGC TAAAATGAAC CAGCAGCGTT CAAGGAGGTT CAGGGCATCA 
AAAGAAGGAA TGGAAGCAGC AGTCGAGAAG CAGCGAGTCA GGGAAGAAAT ATTGGCAAAA 
GGTGGCTTTC TTCCTCCAGA AGAAATAAAA GAAAGATTTG ACAGCAACTG TATTACACCA 
GGAACTGAAT TCATGGACAA TCTTGCTAAA TGCCTTCGCT ATTACATAGC TGATCGTTTA 
AATAATGACC CTGGGTGGAA AAATTTGACA GTTATTTTAT CTGATGCTAG TGCTCCTGGT 
GAAGGAGAAC ATAAAATCAT GGATTACATT AGAAGGCAAA GAGCCCAGCC TAACCATGAC 
CCAAATACTC ATCATTGTTT ATGTGGAGCA GATGCTGATC TCATTATGCT TGGCCTTGCC 
ACACATGAAC CGAACTTTAC CATTATTAGA GAAGAATTCA AACCAAACAA GCCCAAACCA 
TGTGGTCTTT GTAATCAGTT TGGACATGAG GTCAAAGATT GTGAAGGTTT GCCAAGAGAA 
AAGAAGGGAA AGCATGATGA ACTTGCCGAT AGTCTTCCTT GTGCAGAAGG AGAGTTTATC 
TTCCTTCGGC TTAATGTTCT TCGTGAGTAT TTGGAAAGAG AACTCACAAT GGCCAGCCTA 
CCATTCACAT TTGATGTTGA GAGGAGCATT GATGACTGGG TTTTCATGTG CTTCTTTGTG 
GGAAATGACT TCCTCCCTCA TTTGCCATCG TTAGAGATTA GGGAAAATGC AATTGACCGT 
TTGGTTAACA TATACAAAAA TGTGGTACAC AAAACTGGGG GTTACCTTAC AGAAAGTGGT 
TATGTCAATC TGCAAAGAGT ACAGATGATC ATGTTAGCAG TTGGTGAAGT TGAGGATAGC 
ATTTTTAAAA AGAGAAAGGA TGATGAGGAC AGTTTTAGAA GACGACAGAA AGAAAAAAGA 
AAGAGAATGA AGAGAGATCA ACCAGCTTTC ACTCCTAGTG GAATATTAAC TCCTCATGCC 
TTGGGTTCAA GAAATTCACC AGGTTCTCAA GTAGCCAGTA ATCCGAGACA AGCAGCCTAT 
GAAATGAGGA TGCAGAATAA CTCTAGTCCT TCGATATCTC CTAATACGAG TTTCACATCT 
GATGGCTCCC CGTCTCCATT AGGAGGAATT AAGCGAAAAG CAGAAGACAG TGACAGTGAA 
CCTGAGCCAG AGGATAATGT CAGCCATCAA CAACTCTTAG CTGAAAGAGG GATAAGGCCC 
AAGCAAGGAT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

XRN2 ( XM_017027723.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883212.1 Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant X2, mRNA.

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CloneID	OHu92955
Clone ID Related Accession (Same CDS sequence)	XM_017027723.1 , XM_017027723.2
Accession Version	XM_017027723.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	5'-3' exoribonuclease 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAGAG ATCAACCAGC TTTCACTCCT AGTGGAATAT TAACTCCTCA TGCCTTGGGT 
TCAAGAAATT CACCAGGTTC TCAAGTAGCC AGTAATCCGA GACAAGCAGC CTATGAAATG 
AGGATGCAGA ATAACTCTAG TCCTTCGATA TCTCCTAATA CGAGTTTCAC ATCTGATGGC 
TCCCCGTCTC CATTAGGAGG AATTAAGCGA AAAGCAGAAG ACAGTGACAG TGAACCTGAG 
CCAGAGGATA ATGTCAGGTT ATGGGAAGCT GGCTGGAAGC AGCGGTACTA CAAGAACAAA 
TTTGATGTGG ATGCAGCTGA TGAGAAATTC CGTCGGAAAG TTGTGCAGTC GTACGTTGAA 
GGACTTTGCT GGGTTCTTAG ATATTATTAC CAGGGCTGTG CTTCCTGGAA GTGGTATTAT 
CCATTTCATT ATGCACCATT TGCTTCAGAC TTTGAAGGCA TTGCAGACAT GCCATCTGAT 
TTTGAGAAGG GTACGAAACC GTTTAAACCA CTAGAACAAC TTATGGGGGT ATTTCCAGCT 
GCAAGTGGTA ATTTTCTACC TCCATCATGG CGGAAGCTCA TGAGTGATCC TGATTCTAGT 
ATAATTGACT TCTATCCTGA AGATTTTGCT ATTGATTTGA ATGGGAAGAA ATATGCATGG 
CAAGGTGTTG CTCTCTTGCC ATTCGTGGAT GAGCGAAGGC TACGAGCTGC CCTAGAAGAG 
GTATACCCAG ACCTCACTCC AGAAGAGACC AGAAGAAACA GCCTTGGAGG TGATGTCTTA 
TTTGTGGGGA AACATCACCC ACTCCATGAC TTCATTTTAG AGCTGTACCA GACAGGTTCC 
ACAGAGCCAG TGGAGGTACC CCCTGAACTA TGTCATGGGA TTCAAGGAAA GTTTTCTTTG 
GATGAAGAAG CCATTCTTCC AGATCAAATA GTATGTTCTC CTGTTCCTAT GTTAAGGGAT 
CTGACACAGA ACACTGTAGT CAGTATTAAT TTTAAAGACC CACAGTTTGC TGAAGATTAC 
ATTTTTAAAG CTGTAATGCT TCCAGGAGCA AGAAAGCCAG CAGCAGTACT GAAACCTAGT 
GACTGGGAAA AATCCAGCAA TGGACGGCAG TGGAAGCCTC AGCTTGGCTT TAACCGTGAC 
CGGAGGCCTG TGCACCTGGA TCAGGCAGCC TTCAGGACTT TGGGCCATGT GATGCCAAGA 
GGCTCAGGAA CTGGCATTTA CAGCAATGCT GCACCACCAC CTGTGACTTA CCAGGGAAAC 
TTATACAGGC CGCTTTTGAG AGGACAAGCC CAGATTCCAA AACTTATGTC AAATATGAGG 
CCCCAGGATT CCTGGCGAGG TCCTCCTCCC CTTTTCCAGC AGCAAAGGTT TGACAGAGGC 
GTTGGGGCTG AACCTCTGCT CCCATGGAAC CGGATGCTGC AAACCCAGAA TGCAGCCTTC 
CAGCCAAACC AGTACCAGAT GCTAGCTGGG CCTGGTGGGT ATCCACCCAG ACGAGATGAT 
CGTGGAGGGA GACAGGGATA TCCCAGAGAA GGAAGGAAAT ACCCTTTGCC ACCACCCTCA 
GGAAGATACA ATTGGAATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883212.1
CDS	1341..2921
Translation	MKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTYQGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDRGGRQGYPREGRKYPLPPPSGRYNWN

Target ORF information:

RefSeq Version	XM_017027723.1
Organism	Homo sapiens(human)
Definition	Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027723.1

ORF Insert Sequence:

ATGAAGAGAG ATCAACCAGC TTTCACTCCT AGTGGAATAT TAACTCCTCA TGCCTTGGGT 
TCAAGAAATT CACCAGGTTC TCAAGTAGCC AGTAATCCGA GACAAGCAGC CTATGAAATG 
AGGATGCAGA ATAACTCTAG TCCTTCGATA TCTCCTAATA CGAGTTTCAC ATCTGATGGC 
TCCCCGTCTC CATTAGGAGG AATTAAGCGA AAAGCAGAAG ACAGTGACAG TGAACCTGAG 
CCAGAGGATA ATGTCAGGTT ATGGGAAGCT GGCTGGAAGC AGCGGTACTA CAAGAACAAA 
TTTGATGTGG ATGCAGCTGA TGAGAAATTC CGTCGGAAAG TTGTGCAGTC GTACGTTGAA 
GGACTTTGCT GGGTTCTTAG ATATTATTAC CAGGGCTGTG CTTCCTGGAA GTGGTATTAT 
CCATTTCATT ATGCACCATT TGCTTCAGAC TTTGAAGGCA TTGCAGACAT GCCATCTGAT 
TTTGAGAAGG GTACGAAACC GTTTAAACCA CTAGAACAAC TTATGGGGGT ATTTCCAGCT 
GCAAGTGGTA ATTTTCTACC TCCATCATGG CGGAAGCTCA TGAGTGATCC TGATTCTAGT 
ATAATTGACT TCTATCCTGA AGATTTTGCT ATTGATTTGA ATGGGAAGAA ATATGCATGG 
CAAGGTGTTG CTCTCTTGCC ATTCGTGGAT GAGCGAAGGC TACGAGCTGC CCTAGAAGAG 
GTATACCCAG ACCTCACTCC AGAAGAGACC AGAAGAAACA GCCTTGGAGG TGATGTCTTA 
TTTGTGGGGA AACATCACCC ACTCCATGAC TTCATTTTAG AGCTGTACCA GACAGGTTCC 
ACAGAGCCAG TGGAGGTACC CCCTGAACTA TGTCATGGGA TTCAAGGAAA GTTTTCTTTG 
GATGAAGAAG CCATTCTTCC AGATCAAATA GTATGTTCTC CTGTTCCTAT GTTAAGGGAT 
CTGACACAGA ACACTGTAGT CAGTATTAAT TTTAAAGACC CACAGTTTGC TGAAGATTAC 
ATTTTTAAAG CTGTAATGCT TCCAGGAGCA AGAAAGCCAG CAGCAGTACT GAAACCTAGT 
GACTGGGAAA AATCCAGCAA TGGACGGCAG TGGAAGCCTC AGCTTGGCTT TAACCGTGAC 
CGGAGGCCTG TGCACCTGGA TCAGGCAGCC TTCAGGACTT TGGGCCATGT GATGCCAAGA 
GGCTCAGGAA CTGGCATTTA CAGCAATGCT GCACCACCAC CTGTGACTTA CCAGGGAAAC 
TTATACAGGC CGCTTTTGAG AGGACAAGCC CAGATTCCAA AACTTATGTC AAATATGAGG 
CCCCAGGATT CCTGGCGAGG TCCTCCTCCC CTTTTCCAGC AGCAAAGGTT TGACAGAGGC 
GTTGGGGCTG AACCTCTGCT CCCATGGAAC CGGATGCTGC AAACCCAGAA TGCAGCCTTC 
CAGCCAAACC AGTACCAGAT GCTAGCTGGG CCTGGTGGGT ATCCACCCAG ACGAGATGAT 
CGTGGAGGGA GACAGGGATA TCCCAGAGAA GGAAGGAAAT ACCCTTTGCC ACCACCCTCA 
GGAAGATACA ATTGGAATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

XRN2 ( XM_017027723.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016883212.1 Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant X2, mRNA.

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CloneID	OHu92955
Clone ID Related Accession (Same CDS sequence)	XM_017027723.1 , XM_017027723.2
Accession Version	XM_017027723.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1581bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	5'-3' exoribonuclease 2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000020.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017027723.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGAGAG ATCAACCAGC TTTCACTCCT AGTGGAATAT TAACTCCTCA TGCCTTGGGT 
TCAAGAAATT CACCAGGTTC TCAAGTAGCC AGTAATCCGA GACAAGCAGC CTATGAAATG 
AGGATGCAGA ATAACTCTAG TCCTTCGATA TCTCCTAATA CGAGTTTCAC ATCTGATGGC 
TCCCCGTCTC CATTAGGAGG AATTAAGCGA AAAGCAGAAG ACAGTGACAG TGAACCTGAG 
CCAGAGGATA ATGTCAGGTT ATGGGAAGCT GGCTGGAAGC AGCGGTACTA CAAGAACAAA 
TTTGATGTGG ATGCAGCTGA TGAGAAATTC CGTCGGAAAG TTGTGCAGTC GTACGTTGAA 
GGACTTTGCT GGGTTCTTAG ATATTATTAC CAGGGCTGTG CTTCCTGGAA GTGGTATTAT 
CCATTTCATT ATGCACCATT TGCTTCAGAC TTTGAAGGCA TTGCAGACAT GCCATCTGAT 
TTTGAGAAGG GTACGAAACC GTTTAAACCA CTAGAACAAC TTATGGGGGT ATTTCCAGCT 
GCAAGTGGTA ATTTTCTACC TCCATCATGG CGGAAGCTCA TGAGTGATCC TGATTCTAGT 
ATAATTGACT TCTATCCTGA AGATTTTGCT ATTGATTTGA ATGGGAAGAA ATATGCATGG 
CAAGGTGTTG CTCTCTTGCC ATTCGTGGAT GAGCGAAGGC TACGAGCTGC CCTAGAAGAG 
GTATACCCAG ACCTCACTCC AGAAGAGACC AGAAGAAACA GCCTTGGAGG TGATGTCTTA 
TTTGTGGGGA AACATCACCC ACTCCATGAC TTCATTTTAG AGCTGTACCA GACAGGTTCC 
ACAGAGCCAG TGGAGGTACC CCCTGAACTA TGTCATGGGA TTCAAGGAAA GTTTTCTTTG 
GATGAAGAAG CCATTCTTCC AGATCAAATA GTATGTTCTC CTGTTCCTAT GTTAAGGGAT 
CTGACACAGA ACACTGTAGT CAGTATTAAT TTTAAAGACC CACAGTTTGC TGAAGATTAC 
ATTTTTAAAG CTGTAATGCT TCCAGGAGCA AGAAAGCCAG CAGCAGTACT GAAACCTAGT 
GACTGGGAAA AATCCAGCAA TGGACGGCAG TGGAAGCCTC AGCTTGGCTT TAACCGTGAC 
CGGAGGCCTG TGCACCTGGA TCAGGCAGCC TTCAGGACTT TGGGCCATGT GATGCCAAGA 
GGCTCAGGAA CTGGCATTTA CAGCAATGCT GCACCACCAC CTGTGACTTA CCAGGGAAAC 
TTATACAGGC CGCTTTTGAG AGGACAAGCC CAGATTCCAA AACTTATGTC AAATATGAGG 
CCCCAGGATT CCTGGCGAGG TCCTCCTCCC CTTTTCCAGC AGCAAAGGTT TGACAGAGGC 
GTTGGGGCTG AACCTCTGCT CCCATGGAAC CGGATGCTGC AAACCCAGAA TGCAGCCTTC 
CAGCCAAACC AGTACCAGAT GCTAGCTGGG CCTGGTGGGT ATCCACCCAG ACGAGATGAT 
CGTGGAGGGA GACAGGGATA TCCCAGAGAA GGAAGGAAAT ACCCTTTGCC ACCACCCTCA 
GGAAGATACA ATTGGAATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016883212.1
CDS	1383..2963
Translation	MKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTYQGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDRGGRQGYPREGRKYPLPPPSGRYNWN

Target ORF information:

RefSeq Version	XM_017027723.2
Organism	Homo sapiens(human)
Definition	Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017027723.2

ORF Insert Sequence:

ATGAAGAGAG ATCAACCAGC TTTCACTCCT AGTGGAATAT TAACTCCTCA TGCCTTGGGT 
TCAAGAAATT CACCAGGTTC TCAAGTAGCC AGTAATCCGA GACAAGCAGC CTATGAAATG 
AGGATGCAGA ATAACTCTAG TCCTTCGATA TCTCCTAATA CGAGTTTCAC ATCTGATGGC 
TCCCCGTCTC CATTAGGAGG AATTAAGCGA AAAGCAGAAG ACAGTGACAG TGAACCTGAG 
CCAGAGGATA ATGTCAGGTT ATGGGAAGCT GGCTGGAAGC AGCGGTACTA CAAGAACAAA 
TTTGATGTGG ATGCAGCTGA TGAGAAATTC CGTCGGAAAG TTGTGCAGTC GTACGTTGAA 
GGACTTTGCT GGGTTCTTAG ATATTATTAC CAGGGCTGTG CTTCCTGGAA GTGGTATTAT 
CCATTTCATT ATGCACCATT TGCTTCAGAC TTTGAAGGCA TTGCAGACAT GCCATCTGAT 
TTTGAGAAGG GTACGAAACC GTTTAAACCA CTAGAACAAC TTATGGGGGT ATTTCCAGCT 
GCAAGTGGTA ATTTTCTACC TCCATCATGG CGGAAGCTCA TGAGTGATCC TGATTCTAGT 
ATAATTGACT TCTATCCTGA AGATTTTGCT ATTGATTTGA ATGGGAAGAA ATATGCATGG 
CAAGGTGTTG CTCTCTTGCC ATTCGTGGAT GAGCGAAGGC TACGAGCTGC CCTAGAAGAG 
GTATACCCAG ACCTCACTCC AGAAGAGACC AGAAGAAACA GCCTTGGAGG TGATGTCTTA 
TTTGTGGGGA AACATCACCC ACTCCATGAC TTCATTTTAG AGCTGTACCA GACAGGTTCC 
ACAGAGCCAG TGGAGGTACC CCCTGAACTA TGTCATGGGA TTCAAGGAAA GTTTTCTTTG 
GATGAAGAAG CCATTCTTCC AGATCAAATA GTATGTTCTC CTGTTCCTAT GTTAAGGGAT 
CTGACACAGA ACACTGTAGT CAGTATTAAT TTTAAAGACC CACAGTTTGC TGAAGATTAC 
ATTTTTAAAG CTGTAATGCT TCCAGGAGCA AGAAAGCCAG CAGCAGTACT GAAACCTAGT 
GACTGGGAAA AATCCAGCAA TGGACGGCAG TGGAAGCCTC AGCTTGGCTT TAACCGTGAC 
CGGAGGCCTG TGCACCTGGA TCAGGCAGCC TTCAGGACTT TGGGCCATGT GATGCCAAGA 
GGCTCAGGAA CTGGCATTTA CAGCAATGCT GCACCACCAC CTGTGACTTA CCAGGGAAAC 
TTATACAGGC CGCTTTTGAG AGGACAAGCC CAGATTCCAA AACTTATGTC AAATATGAGG 
CCCCAGGATT CCTGGCGAGG TCCTCCTCCC CTTTTCCAGC AGCAAAGGTT TGACAGAGGC 
GTTGGGGCTG AACCTCTGCT CCCATGGAAC CGGATGCTGC AAACCCAGAA TGCAGCCTTC 
CAGCCAAACC AGTACCAGAT GCTAGCTGGG CCTGGTGGGT ATCCACCCAG ACGAGATGAT 
CGTGGAGGGA GACAGGGATA TCCCAGAGAA GGAAGGAAAT ACCCTTTGCC ACCACCCTCA 
GGAAGATACA ATTGGAATTA A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

XRN2 ( NM_001317960.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304889.1 Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu64947
Clone ID Related Accession (Same CDS sequence)	NM_001317960.1
Accession Version	NM_001317960.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3087bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-23
Organism	Homo sapiens(human)
Product	5'-3' exoribonuclease 2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC403143.1, AL117332.16, AK302846.1 and AF152169.1. On Dec 17, 2015 this sequence version replaced XM_011529184.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK302846.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END##

ATGGGCTCCG CCGCCTGCCC CCGGGGAGCC TTGCCGGAGC TCGCGCCCTG CTGCCAGCCT 
CGCGAGCAGT CGCAGCCCCA CACGCGATGG GACGCGGGCT GTGGGATTCA GCACCCCGGG 
GGCGAGGAAT TCAGGACCCT CGGCGGGGCA AGGGCCTATA GGGTTCCGAA CTCGCAGGAG 
GGTCGCTCCT CCCCTACTCG CTTTTTCCCG GCACCGGAAG GCCCCGCCCA CTGCTTTGTT 
TCCTCTCCAG ACCGCGCATT TTGGGTCTCG GAAGAGGTTC AGAGGCTGTT GTTGAGCAAT 
GCATGCCAGC CAAAAGAATG CAATGGTGTA AAGATTCCAG TTGATGCCAG TAAACCTAAT 
CCAAATGATG TGGAGTTTGA TAATCTGTAT TTGGATATGA ATGGAATCAT CCATCCCTGT 
ACTCATCCTG AAGACAAACC AGCACCAAAA AATGAAGATG AAATGATGGT TGCAATTTTT 
GAGTACATTG ACAGACTTTT CAGTATTGTA AGACCAAGAA GACTTCTCTA CATGGCAATA 
GATGGAGTGG CACCACGTGC TAAAATGAAC CAGCAGCGTT CAAGGAGGTT CAGGGCATCA 
AAAGAAGGAA TGGAAGCAGC AGTCGAGAAG CAGCGAGTCA GGGAAGAAAT ATTGGCAAAA 
GGTGGCTTTC TTCCTCCAGA AGAAATAAAA GAAAGATTTG ACAGCAACTG TATTACACCA 
GGAACTGAAT TCATGGACAA TCTTGCTAAA TGCCTTCGCT ATTACATAGC TGATCGTTTA 
AATAATGACC CTGGGTGGAA AAATTTGACA GTTATTTTAT CTGATGCTAG TGCTCCTGGT 
GAAGGAGAAC ATAAAATCAT GGATTACATT AGAAGGCAAA GAGCCCAGCC TAACCATGAC 
CCAAATACTC ATCATTGTTT ATGTGGAGCA GATGCTGATC TCATTATGCT TGGCCTTGCC 
ACACATGAAC CGAACTTTAC CATTATTAGA GAAGAATTCA AACCAAACAA GCCCAAACCA 
TGTGGTCTTT GTAATCAGTT TGGACATGAG GTCAAAGATT GTGAAGGTTT GCCAAGAGAA 
AAGAAGGGAA AGCATGATGA ACTTGCCGAT AGTCTTCCTT GTGCAGAAGG AGAGTTTATC 
TTCCTTCGGC TTAATGTTCT TCGTGAGTAT TTGGAAAGAG AACTCACAAT GGCCAGCCTA 
CCATTCACAT TTGATGTTGA GAGGAGCATT GATGACTGGG TTTTCATGTG CTTCTTTGTG 
GGAAATGACT TCCTCCCTCA TTTGCCATCG TTAGAGATTA GGGAAAATGC AATTGACCGT 
TTGGTTAACA TATACAAAAA TGTGGTACAC AAAACTGGGG GTTACCTTAC AGAAAGTGGT 
TATGTCAATC TGCAAAGAGT ACAGATGATC ATGTTAGCAG TTGGTGAAGT TGAGGATAGC 
ATTTTTAAAA AGAGAAAGGA TGATGAGGAC AGTTTTAGAA GACGACAGAA AGAAAAAAGA 
AAGAGAATGA AGAGAGATCA ACCAGCTTTC ACTCCTAGTG GAATATTAAC TCCTCATGCC 
TTGGGTTCAA GAAATTCACC AGGTTCTCAA GTAGCCAGTA ATCCGAGACA AGCAGCCTAT 
GAAATGAGGA TGCAGAATAA CTCTAGTCCT TCGATATCTC CTAATACGAG TTTCACATCT 
GATGGCTCCC CGTCTCCATT AGGAGGAATT AAGCGAAAAG CAGAAGACAG TGACAGTGAA 
CCTGAGCCAG AGGATAATGT CAGGTTATGG GAAGCTGGCT GGAAGCAGCG GTACTACAAG 
AACAAATTTG ATGTGGATGC AGCTGATGAG AAATTCCGTC GGAAAGTTGT GCAGTCGTAC 
GTTGAAGGAC TTTGCTGGGT TCTTAGATAT TATTACCAGG GCTGTGCTTC CTGGAAGTGG 
TATTATCCAT TTCATTATGC ACCATTTGCT TCAGACTTTG AAGGCATTGC AGACATGCCA 
TCTGATTTTG AGAAGGGTAC GAAACCGTTT AAACCACTAG AACAACTTAT GGGGGTATTT 
CCAGCTGCAA GTGGTAATTT TCTACCTCCA TCATGGCGGA AGCTCATGAG TGATCCTGAT 
TCTAGTATAA TTGACTTCTA TCCTGAAGAT TTTGCTATTG ATTTGAATGG GAAGAAATAT 
GCATGGCAAG GTGTTGCTCT CTTGCCATTC GTGGATGAGC GAAGGCTACG AGCTGCCCTA 
GAAGAGGTAT ACCCAGACCT CACTCCAGAA GAGACCAGAA GAAACAGCCT TGGAGGTGAT 
GTCTTATTTG TGGGGAAACA TCACCCACTC CATGACTTCA TTTTAGAGCT GTACCAGACA 
GGTTCCACAG AGCCAGTGGA GGTACCCCCT GAACTATGTC ATGGGATTCA AGGAAAGTTT 
TCTTTGGATG AAGAAGCCAT TCTTCCAGAT CAAATAGTAT GTTCTCCTGT TCCTATGTTA 
AGGGATCTGA CACAGAACAC TGTAGTCAGT ATTAATTTTA AAGACCCACA GTTTGCTGAA 
GATTACATTT TTAAAGCTGT AATGCTTCCA GGAGCAAGAA AGCCAGCAGC AGTACTGAAA 
CCTAGTGACT GGGAAAAATC CAGCAATGGA CGGCAGTGGA AGCCTCAGCT TGGCTTTAAC 
CGTGACCGGA GGCCTGTGCA CCTGGATCAG GCAGCCTTCA GGACTTTGGG CCATGTGATG 
CCAAGAGGCT CAGGAACTGG CATTTACAGC AATGCTGCAC CACCACCTGT GACTTACCAG 
GGAAACTTAT ACAGGCCGCT TTTGAGAGGA CAAGCCCAGA TTCCAAAACT TATGTCAAAT 
ATGAGGCCCC AGGATTCCTG GCGAGGTCCT CCTCCCCTTT TCCAGCAGCA AAGGTTTGAC 
AGAGGCGTTG GGGCTGAACC TCTGCTCCCA TGGAACCGGA TGCTGCAAAC CCAGAATGCA 
GCCTTCCAGC CAAACCAGTA CCAGATGCTA GCTGGGCCTG GTGGGTATCC ACCCAGACGA 
GATGATCGTG GAGGGAGACA GGGATATCCC AGAGAAGGAA GGAAATACCC TTTGCCACCA 
CCCTCAGGAA GATACAATTG GAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304889.1
CDS	42..3128
Translation	MGSAACPRGALPELAPCCQPREQSQPHTRWDAGCGIQHPGGEEFRTLGGARAYRVPNSQEGRSSPTRFFPAPEGPAHCFVSSPDRAFWVSEEVQRLLLSNACQPKECNGVKIPVDASKPNPNDVEFDNLYLDMNGIIHPCTHPEDKPAPKNEDEMMVAIFEYIDRLFSIVRPRRLLYMAIDGVAPRAKMNQQRSRRFRASKEGMEAAVEKQRVREEILAKGGFLPPEEIKERFDSNCITPGTEFMDNLAKCLRYYIADRLNNDPGWKNLTVILSDASAPGEGEHKIMDYIRRQRAQPNHDPNTHHCLCGADADLIMLGLATHEPNFTIIREEFKPNKPKPCGLCNQFGHEVKDCEGLPREKKGKHDELADSLPCAEGEFIFLRLNVLREYLERELTMASLPFTFDVERSIDDWVFMCFFVGNDFLPHLPSLEIRENAIDRLVNIYKNVVHKTGGYLTESGYVNLQRVQMIMLAVGEVEDSIFKKRKDDEDSFRRRQKEKRKRMKRDQPAFTPSGILTPHALGSRNSPGSQVASNPRQAAYEMRMQNNSSPSISPNTSFTSDGSPSPLGGIKRKAEDSDSEPEPEDNVRLWEAGWKQRYYKNKFDVDAADEKFRRKVVQSYVEGLCWVLRYYYQGCASWKWYYPFHYAPFASDFEGIADMPSDFEKGTKPFKPLEQLMGVFPAASGNFLPPSWRKLMSDPDSSIIDFYPEDFAIDLNGKKYAWQGVALLPFVDERRLRAALEEVYPDLTPEETRRNSLGGDVLFVGKHHPLHDFILELYQTGSTEPVEVPPELCHGIQGKFSLDEEAILPDQIVCSPVPMLRDLTQNTVVSINFKDPQFAEDYIFKAVMLPGARKPAAVLKPSDWEKSSNGRQWKPQLGFNRDRRPVHLDQAAFRTLGHVMPRGSGTGIYSNAAPPPVTYQGNLYRPLLRGQAQIPKLMSNMRPQDSWRGPPPLFQQQRFDRGVGAEPLLPWNRMLQTQNAAFQPNQYQMLAGPGGYPPRRDDRGGRQGYPREGRKYPLPPPSGRYNWN

Target ORF information:

RefSeq Version	NM_001317960.1
Organism	Homo sapiens(human)
Definition	Homo sapiens 5'-3' exoribonuclease 2 (XRN2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317960.1

ORF Insert Sequence:

ATGGGCTCCG CCGCCTGCCC CCGGGGAGCC TTGCCGGAGC TCGCGCCCTG CTGCCAGCCT 
CGCGAGCAGT CGCAGCCCCA CACGCGATGG GACGCGGGCT GTGGGATTCA GCACCCCGGG 
GGCGAGGAAT TCAGGACCCT CGGCGGGGCA AGGGCCTATA GGGTTCCGAA CTCGCAGGAG 
GGTCGCTCCT CCCCTACTCG CTTTTTCCCG GCACCGGAAG GCCCCGCCCA CTGCTTTGTT 
TCCTCTCCAG ACCGCGCATT TTGGGTCTCG GAAGAGGTTC AGAGGCTGTT GTTGAGCAAT 
GCATGCCAGC CAAAAGAATG CAATGGTGTA AAGATTCCAG TTGATGCCAG TAAACCTAAT 
CCAAATGATG TGGAGTTTGA TAATCTGTAT TTGGATATGA ATGGAATCAT CCATCCCTGT 
ACTCATCCTG AAGACAAACC AGCACCAAAA AATGAAGATG AAATGATGGT TGCAATTTTT 
GAGTACATTG ACAGACTTTT CAGTATTGTA AGACCAAGAA GACTTCTCTA CATGGCAATA 
GATGGAGTGG CACCACGTGC TAAAATGAAC CAGCAGCGTT CAAGGAGGTT CAGGGCATCA 
AAAGAAGGAA TGGAAGCAGC AGTCGAGAAG CAGCGAGTCA GGGAAGAAAT ATTGGCAAAA 
GGTGGCTTTC TTCCTCCAGA AGAAATAAAA GAAAGATTTG ACAGCAACTG TATTACACCA 
GGAACTGAAT TCATGGACAA TCTTGCTAAA TGCCTTCGCT ATTACATAGC TGATCGTTTA 
AATAATGACC CTGGGTGGAA AAATTTGACA GTTATTTTAT CTGATGCTAG TGCTCCTGGT 
GAAGGAGAAC ATAAAATCAT GGATTACATT AGAAGGCAAA GAGCCCAGCC TAACCATGAC 
CCAAATACTC ATCATTGTTT ATGTGGAGCA GATGCTGATC TCATTATGCT TGGCCTTGCC 
ACACATGAAC CGAACTTTAC CATTATTAGA GAAGAATTCA AACCAAACAA GCCCAAACCA 
TGTGGTCTTT GTAATCAGTT TGGACATGAG GTCAAAGATT GTGAAGGTTT GCCAAGAGAA 
AAGAAGGGAA AGCATGATGA ACTTGCCGAT AGTCTTCCTT GTGCAGAAGG AGAGTTTATC 
TTCCTTCGGC TTAATGTTCT TCGTGAGTAT TTGGAAAGAG AACTCACAAT GGCCAGCCTA 
CCATTCACAT TTGATGTTGA GAGGAGCATT GATGACTGGG TTTTCATGTG CTTCTTTGTG 
GGAAATGACT TCCTCCCTCA TTTGCCATCG TTAGAGATTA GGGAAAATGC AATTGACCGT 
TTGGTTAACA TATACAAAAA TGTGGTACAC AAAACTGGGG GTTACCTTAC AGAAAGTGGT 
TATGTCAATC TGCAAAGAGT ACAGATGATC ATGTTAGCAG TTGGTGAAGT TGAGGATAGC 
ATTTTTAAAA AGAGAAAGGA TGATGAGGAC AGTTTTAGAA GACGACAGAA AGAAAAAAGA 
AAGAGAATGA AGAGAGATCA ACCAGCTTTC ACTCCTAGTG GAATATTAAC TCCTCATGCC 
TTGGGTTCAA GAAATTCACC AGGTTCTCAA GTAGCCAGTA ATCCGAGACA AGCAGCCTAT 
GAAATGAGGA TGCAGAATAA CTCTAGTCCT TCGATATCTC CTAATACGAG TTTCACATCT 
GATGGCTCCC CGTCTCCATT AGGAGGAATT AAGCGAAAAG CAGAAGACAG TGACAGTGAA 
CCTGAGCCAG AGGATAATGT CAGGTTATGG GAAGCTGGCT GGAAGCAGCG GTACTACAAG 
AACAAATTTG ATGTGGATGC AGCTGATGAG AAATTCCGTC GGAAAGTTGT GCAGTCGTAC 
GTTGAAGGAC TTTGCTGGGT TCTTAGATAT TATTACCAGG GCTGTGCTTC CTGGAAGTGG 
TATTATCCAT TTCATTATGC ACCATTTGCT TCAGACTTTG AAGGCATTGC AGACATGCCA 
TCTGATTTTG AGAAGGGTAC GAAACCGTTT AAACCACTAG AACAACTTAT GGGGGTATTT 
CCAGCTGCAA GTGGTAATTT TCTACCTCCA TCATGGCGGA AGCTCATGAG TGATCCTGAT 
TCTAGTATAA TTGACTTCTA TCCTGAAGAT TTTGCTATTG ATTTGAATGG GAAGAAATAT 
GCATGGCAAG GTGTTGCTCT CTTGCCATTC GTGGATGAGC GAAGGCTACG AGCTGCCCTA 
GAAGAGGTAT ACCCAGACCT CACTCCAGAA GAGACCAGAA GAAACAGCCT TGGAGGTGAT 
GTCTTATTTG TGGGGAAACA TCACCCACTC CATGACTTCA TTTTAGAGCT GTACCAGACA 
GGTTCCACAG AGCCAGTGGA GGTACCCCCT GAACTATGTC ATGGGATTCA AGGAAAGTTT 
TCTTTGGATG AAGAAGCCAT TCTTCCAGAT CAAATAGTAT GTTCTCCTGT TCCTATGTTA 
AGGGATCTGA CACAGAACAC TGTAGTCAGT ATTAATTTTA AAGACCCACA GTTTGCTGAA 
GATTACATTT TTAAAGCTGT AATGCTTCCA GGAGCAAGAA AGCCAGCAGC AGTACTGAAA 
CCTAGTGACT GGGAAAAATC CAGCAATGGA CGGCAGTGGA AGCCTCAGCT TGGCTTTAAC 
CGTGACCGGA GGCCTGTGCA CCTGGATCAG GCAGCCTTCA GGACTTTGGG CCATGTGATG 
CCAAGAGGCT CAGGAACTGG CATTTACAGC AATGCTGCAC CACCACCTGT GACTTACCAG 
GGAAACTTAT ACAGGCCGCT TTTGAGAGGA CAAGCCCAGA TTCCAAAACT TATGTCAAAT 
ATGAGGCCCC AGGATTCCTG GCGAGGTCCT CCTCCCCTTT TCCAGCAGCA AAGGTTTGAC 
AGAGGCGTTG GGGCTGAACC TCTGCTCCCA TGGAACCGGA TGCTGCAAAC CCAGAATGCA 
GCCTTCCAGC CAAACCAGTA CCAGATGCTA GCTGGGCCTG GTGGGTATCC ACCCAGACGA 
GATGATCGTG GAGGGAGACA GGGATATCCC AGAGAAGGAA GGAAATACCC TTTGCCACCA 
CCCTCAGGAA GATACAATTG GAATTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

XRN2 promotes EMT and metastasis through regulating maturation of miR-10a.
Oncogene36(27)3925-3933(2017 Jul)
Zhang H,Lu Y,Chen E,Li X,Lv B,Vikis HG,Liu P

The G-patch protein NF-?B-repressing factor mediates the recruitment of the exonuclease XRN2 and activation of the RNA helicase DHX15 in human ribosome biogenesis.
Nucleic acids research45(9)5359-5374(2017 May)
Memet I,Doebele C,Sloan KE,Bohnsack MT

XRN2 Links Transcription Termination to DNA Damage and Replication Stress.
PLoS genetics12(7)e1006107(2016 07)
Morales JC,Richard P,Patidar PL,Motea EA,Dang TT,Manley JL,Boothman DA

Structural basis and function of XRN2 binding by XTB domains.
Nature structural & molecular biology23(2)164-71(2016 Feb)
Richter H,Katic I,Gut H,Gro?hans H

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XRN2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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