FGF10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FGF10
Entrez Gene ID	2255
Full Name	fibroblast growth factor 10
General protein information	Preferred Names fibroblast growth factor 10 Names fibroblast growth factor 10 FGF-10 keratinocyte growth factor 2 produced by fibroblasts of urinary bladder lamina propria
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 5 Map Location: 5p12
Summary	The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies of the mouse homolog of suggested that this gene is required for embryonic epidermal morphogenesis including brain development, lung morphogenesis, and initiation of lim bud formation. This gene is also implicated to be a primary factor in the process of wound healing. [provided by RefSeq, Jul 2008].
Disorder MIM:	602115
Disorder Html:	Aplasia of lacrimal and salivary glands, 180920 (3); LADD syndrome, 149730 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_005248264.3	XP_005248321.1	fibroblast growth factor 10 isoform X1
XM_005248264.4	XP_005248321.1	fibroblast growth factor 10 isoform X1
NM_004465.1	NP_004456.1	fibroblast growth factor 10 precursor
XM_005248264.2	XP_005248321.1	fibroblast growth factor 10 isoform X1
NM_004465.2	NP_004456.1	fibroblast growth factor 10 precursor

Pathways from BioSystems

Homologies

	FGF10	XP_001092583.1
Bos taurus (cattle)	FGF10	NP_001193255.1
Rattus norvegicus (Norway rat)	Fgf10	NP_037083.1
Danio rerio (zebrafish)	fgf10a	NP_878290.1
Pan troglodytes (chimpanzee)	FGF10	XP_526931.2
Canis lupus familiaris (dog)	FGF10	XP_005619394.1
Xenopus tropicalis (tropical clawed frog)	fgf10	NP_001016169.1
Homo sapiens (human)	FGF10	NP_004456.1
Gallus gallus (chicken)	FGF10	NP_990027.1
Danio rerio (zebrafish)	fgf10b	NP_001039323.1
Mus musculus (house mouse)	Fgf10	NP_032028.1

Gene Ontology
Bibliography

Related articles in PubMed

New pathogenic variant in the FGF10 gene in the agenesis of lacrimal and salivary gland syndrome: Ophthalmological and genetic study.
Rodrigo MJ, Idoipe M, Izquierdo S, Satue M, Mateo A, Sanchez A, Garcia-Martin E, Pablo L
Ophthalmic genetics39(1)125-128(2018 Jan-Feb)

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.
Ghoussaini M, French JD, Michailidou K, Nord S, Beesley J, Canisus S, Hillman KM, Kaufmann S, Sivakumaran H, Moradi Marjaneh M, Lee JS, Dennis J, Bolla MK, Wang Q, Dicks E, Milne RL, Hopper JL, Southey MC, Schmidt MK, Broeks A, Muir K, Lophatananon A, Fasching PA, Beckmann MW, Fletcher O, Johnson N, Sawyer EJ, Tomlinson I, Burwinkel B, Marme F, Gu?nel P, Truong T, Bojesen SE, Flyger H, Benitez J, Gonz?lez-Neira A, Alonso MR, Pita G, Neuhausen SL, Anton-Culver H, Brenner H, Arndt V, Meindl A, Schmutzler RK, Brauch H, Hamann U, Tessier DC, Vincent D, Nevanlinna H, Khan S, Matsuo K, Ito H, D?rk T, Bogdanova NV, Lindblom A, Margolin S, Mannermaa A, Kosma VM, , Wu AH, Van Den Berg D, Lambrechts D, Floris G, Chang-Claude J, Rudolph A, Radice P, Barile M, Couch FJ, Hallberg E, Giles GG, Haiman CA, Le Marchand L, Goldberg MS, Teo SH, Yip CH, Borresen-Dale AL, , Zheng W, Cai Q, Winqvist R, Pylk?s K, Andrulis IL, Devilee P, Tollenaar RA, Garc?a-Closas M, Figueroa J, Hall P, Czene K, Brand JS, Darabi H, Eriksson M, Hooning MJ, Koppert LB, Li J, Shu XO, Zheng Y, Cox A, Cross SS, Shah M, Rhenius V, Choi JY, Kang D, Hartman M, Chia KS, Kabisch M, Torres D, Luccarini C, Conroy DM, Jakubowska A, Lubinski J, Sangrajrang S, Brennan P, Olswold C, Slager S, Shen CY, Hou MF, Swerdlow A, Schoemaker MJ, Simard J, Pharoah PD, Kristensen V, Chenevix-Trench G, Easton DF, Dunning AM, Edwards SL
American journal of human genetics99(4)903-911(2016 Oct)

Fibroblast Growth Factor Ligand Dependent Proliferation and Chondrogenic Differentiation of Synovium-Derived Stem Cells and Concomitant Adaptation of Wnt/Mitogen-Activated Protein Kinase Signals.
Pizzute T, Li J, Zhang Y, Davis ME, Pei M
Tissue engineering. Part A22(15-16)1036-46(2016 08)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

data suggest that the strongest signal of association at 5p12 is mediated through coordinated activation of FGF10 and MRPS30, two candidate genes for breast cancer pathogenesis
Title: Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.

These results indicated that FGF-2, but not FGF-10, may be supplemented during stem cell expansion to prime cells for successful chondrogenesis and osteogenesis.
Title: Fibroblast Growth Factor Ligand Dependent Proliferation and Chondrogenic Differentiation of Synovium-Derived Stem Cells and Concomitant Adaptation of Wnt/Mitogen-Activated Protein Kinase Signals.

The present data indicate that non-natural FGFR2 ligands, such as FGF10 and FGF19, are important factors in the pathophysiology of Aspert syndrome.
Title: Cell Type-Dependent Nonspecific Fibroblast Growth Factor Signaling in Apert Syndrome.

Fgf10 signaling has an essential role in the formation of lipofibroblasts during late lung development
Title: Evidence for the involvement of fibroblast growth factor 10 in lipofibroblast formation during embryonic lung development.

Expression of Fibroblast Growth Factor 10 is correlated with poor prognosis in gastric adenocarcinoma.
Title: Expression of Fibroblast Growth Factor 10 Is Correlated with Poor Prognosis in Gastric Adenocarcinoma.

The following FGF10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGF10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu26758	NM_004465.2 Latest version!	Homo sapiens fibroblast growth factor 10 (FGF10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu26758	XM_005248264.4 Latest version!	Homo sapiens fibroblast growth factor 10 (FGF10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu26758	XM_005248264.3	Homo sapiens fibroblast growth factor 10 (FGF10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu26758	XM_005248264.2	Homo sapiens fibroblast growth factor 10 (FGF10), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu26758	NM_004465.1	Homo sapiens fibroblast growth factor 10 (FGF10), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FGF10 ( NM_004465.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_004456.1 Homo sapiens fibroblast growth factor 10 (FGF10), mRNA.

Price & Availability↑

CloneID	OHu26758
Clone ID Related Accession (Same CDS sequence)	XM_005248264.3 , XM_005248264.4 , NM_004465.1 , XM_005248264.2 , NM_004465.2
Accession Version	NM_004465.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-07
Organism	Homo sapiens(human)
Product	fibroblast growth factor 10 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB002097.1. This sequence is a reference standard in the RefSeqGene project. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC069561.1, AB002097.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2151358, SAMEA2155984 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGTGGAAAT GGATACTGAC ACATTGTGCC TCAGCCTTTC CCCACCTGCC CGGCTGCTGC 
TGCTGCTGCT TTTTGTTGCT GTTCTTGGTG TCTTCCGTCC CTGTCACCTG CCAAGCCCTT 
GGTCAGGACA TGGTGTCACC AGAGGCCACC AACTCTTCTT CCTCCTCCTT CTCCTCTCCT 
TCCAGCGCGG GAAGGCATGT GCGGAGCTAC AATCACCTTC AAGGAGATGT CCGCTGGAGA 
AAGCTATTCT CTTTCACCAA GTACTTTCTC AAGATTGAGA AGAACGGGAA GGTCAGCGGG 
ACCAAGAAGG AGAACTGCCC GTACAGCATC CTGGAGATAA CATCAGTAGA AATCGGAGTT 
GTTGCCGTCA AAGCCATTAA CAGCAACTAT TACTTAGCCA TGAACAAGAA GGGGAAACTC 
TATGGCTCAA AAGAATTTAA CAATGACTGT AAGCTGAAGG AGAGGATAGA GGAAAATGGA 
TACAATACCT ATGCATCATT TAACTGGCAG CATAATGGGA GGCAAATGTA TGTGGCATTG 
AATGGAAAAG GAGCTCCAAG GAGAGGACAG AAAACACGAA GGAAAAACAC CTCTGCTCAC 
TTTCTTCCAA TGGTGGTACA CTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004456.1
CDS	1..627
Translation	MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS

Target ORF information:

RefSeq Version	NM_004465.1
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 10 (FGF10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004465.1

ORF Insert Sequence:

ATGTGGAAAT GGATACTGAC ACATTGTGCC TCAGCCTTTC CCCACCTGCC CGGCTGCTGC 
TGCTGCTGCT TTTTGTTGCT GTTCTTGGTG TCTTCCGTCC CTGTCACCTG CCAAGCCCTT 
GGTCAGGACA TGGTGTCACC AGAGGCCACC AACTCTTCTT CCTCCTCCTT CTCCTCTCCT 
TCCAGCGCGG GAAGGCATGT GCGGAGCTAC AATCACCTTC AAGGAGATGT CCGCTGGAGA 
AAGCTATTCT CTTTCACCAA GTACTTTCTC AAGATTGAGA AGAACGGGAA GGTCAGCGGG 
ACCAAGAAGG AGAACTGCCC GTACAGCATC CTGGAGATAA CATCAGTAGA AATCGGAGTT 
GTTGCCGTCA AAGCCATTAA CAGCAACTAT TACTTAGCCA TGAACAAGAA GGGGAAACTC 
TATGGCTCAA AAGAATTTAA CAATGACTGT AAGCTGAAGG AGAGGATAGA GGAAAATGGA 
TACAATACCT ATGCATCATT TAACTGGCAG CATAATGGGA GGCAAATGTA TGTGGCATTG 
AATGGAAAAG GAGCTCCAAG GAGAGGACAG AAAACACGAA GGAAAAACAC CTCTGCTCAC 
TTTCTTCCAA TGGTGGTACA CTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF10 ( NM_004465.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004456.1 Homo sapiens fibroblast growth factor 10 (FGF10), mRNA.

Price & Availability↑

CloneID	OHu26758
Clone ID Related Accession (Same CDS sequence)	XM_005248264.3 , XM_005248264.4 , NM_004465.1 , XM_005248264.2 , NM_004465.2
Accession Version	NM_004465.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	fibroblast growth factor 10 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA795795.1, BX955123.1, DR003252.1, AB002097.1 and AC093537.2. This sequence is a reference standard in the RefSeqGene project. On Jul 10, 2019 this sequence version replaced NM_004465.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.154482.1, SRR1660803.99825.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGTGGAAAT GGATACTGAC ACATTGTGCC TCAGCCTTTC CCCACCTGCC CGGCTGCTGC 
TGCTGCTGCT TTTTGTTGCT GTTCTTGGTG TCTTCCGTCC CTGTCACCTG CCAAGCCCTT 
GGTCAGGACA TGGTGTCACC AGAGGCCACC AACTCTTCTT CCTCCTCCTT CTCCTCTCCT 
TCCAGCGCGG GAAGGCATGT GCGGAGCTAC AATCACCTTC AAGGAGATGT CCGCTGGAGA 
AAGCTATTCT CTTTCACCAA GTACTTTCTC AAGATTGAGA AGAACGGGAA GGTCAGCGGG 
ACCAAGAAGG AGAACTGCCC GTACAGCATC CTGGAGATAA CATCAGTAGA AATCGGAGTT 
GTTGCCGTCA AAGCCATTAA CAGCAACTAT TACTTAGCCA TGAACAAGAA GGGGAAACTC 
TATGGCTCAA AAGAATTTAA CAATGACTGT AAGCTGAAGG AGAGGATAGA GGAAAATGGA 
TACAATACCT ATGCATCATT TAACTGGCAG CATAATGGGA GGCAAATGTA TGTGGCATTG 
AATGGAAAAG GAGCTCCAAG GAGAGGACAG AAAACACGAA GGAAAAACAC CTCTGCTCAC 
TTTCTTCCAA TGGTGGTACA CTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004456.1
CDS	739..1365
Translation	MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS

Target ORF information:

RefSeq Version	NM_004465.2
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 10 (FGF10), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004465.2

ORF Insert Sequence:

ATGTGGAAAT GGATACTGAC ACATTGTGCC TCAGCCTTTC CCCACCTGCC CGGCTGCTGC 
TGCTGCTGCT TTTTGTTGCT GTTCTTGGTG TCTTCCGTCC CTGTCACCTG CCAAGCCCTT 
GGTCAGGACA TGGTGTCACC AGAGGCCACC AACTCTTCTT CCTCCTCCTT CTCCTCTCCT 
TCCAGCGCGG GAAGGCATGT GCGGAGCTAC AATCACCTTC AAGGAGATGT CCGCTGGAGA 
AAGCTATTCT CTTTCACCAA GTACTTTCTC AAGATTGAGA AGAACGGGAA GGTCAGCGGG 
ACCAAGAAGG AGAACTGCCC GTACAGCATC CTGGAGATAA CATCAGTAGA AATCGGAGTT 
GTTGCCGTCA AAGCCATTAA CAGCAACTAT TACTTAGCCA TGAACAAGAA GGGGAAACTC 
TATGGCTCAA AAGAATTTAA CAATGACTGT AAGCTGAAGG AGAGGATAGA GGAAAATGGA 
TACAATACCT ATGCATCATT TAACTGGCAG CATAATGGGA GGCAAATGTA TGTGGCATTG 
AATGGAAAAG GAGCTCCAAG GAGAGGACAG AAAACACGAA GGAAAAACAC CTCTGCTCAC 
TTTCTTCCAA TGGTGGTACA CTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF10 ( XM_005248264.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005248321.1 Homo sapiens fibroblast growth factor 10 (FGF10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu26758
Clone ID Related Accession (Same CDS sequence)	XM_005248264.3 , XM_005248264.4 , NM_004465.1 , XM_005248264.2 , NM_004465.2
Accession Version	XM_005248264.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	fibroblast growth factor 10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005248264.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGAAAT GGATACTGAC ACATTGTGCC TCAGCCTTTC CCCACCTGCC CGGCTGCTGC 
TGCTGCTGCT TTTTGTTGCT GTTCTTGGTG TCTTCCGTCC CTGTCACCTG CCAAGCCCTT 
GGTCAGGACA TGGTGTCACC AGAGGCCACC AACTCTTCTT CCTCCTCCTT CTCCTCTCCT 
TCCAGCGCGG GAAGGCATGT GCGGAGCTAC AATCACCTTC AAGGAGATGT CCGCTGGAGA 
AAGCTATTCT CTTTCACCAA GTACTTTCTC AAGATTGAGA AGAACGGGAA GGTCAGCGGG 
ACCAAGAAGG AGAACTGCCC GTACAGCATC CTGGAGATAA CATCAGTAGA AATCGGAGTT 
GTTGCCGTCA AAGCCATTAA CAGCAACTAT TACTTAGCCA TGAACAAGAA GGGGAAACTC 
TATGGCTCAA AAGAATTTAA CAATGACTGT AAGCTGAAGG AGAGGATAGA GGAAAATGGA 
TACAATACCT ATGCATCATT TAACTGGCAG CATAATGGGA GGCAAATGTA TGTGGCATTG 
AATGGAAAAG GAGCTCCAAG GAGAGGACAG AAAACACGAA GGAAAAACAC CTCTGCTCAC 
TTTCTTCCAA TGGTGGTACA CTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005248321.1
CDS	1008..1634
Translation	MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS

Target ORF information:

RefSeq Version	XM_005248264.3
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 10 (FGF10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005248264.3

ORF Insert Sequence:

ATGTGGAAAT GGATACTGAC ACATTGTGCC TCAGCCTTTC CCCACCTGCC CGGCTGCTGC 
TGCTGCTGCT TTTTGTTGCT GTTCTTGGTG TCTTCCGTCC CTGTCACCTG CCAAGCCCTT 
GGTCAGGACA TGGTGTCACC AGAGGCCACC AACTCTTCTT CCTCCTCCTT CTCCTCTCCT 
TCCAGCGCGG GAAGGCATGT GCGGAGCTAC AATCACCTTC AAGGAGATGT CCGCTGGAGA 
AAGCTATTCT CTTTCACCAA GTACTTTCTC AAGATTGAGA AGAACGGGAA GGTCAGCGGG 
ACCAAGAAGG AGAACTGCCC GTACAGCATC CTGGAGATAA CATCAGTAGA AATCGGAGTT 
GTTGCCGTCA AAGCCATTAA CAGCAACTAT TACTTAGCCA TGAACAAGAA GGGGAAACTC 
TATGGCTCAA AAGAATTTAA CAATGACTGT AAGCTGAAGG AGAGGATAGA GGAAAATGGA 
TACAATACCT ATGCATCATT TAACTGGCAG CATAATGGGA GGCAAATGTA TGTGGCATTG 
AATGGAAAAG GAGCTCCAAG GAGAGGACAG AAAACACGAA GGAAAAACAC CTCTGCTCAC 
TTTCTTCCAA TGGTGGTACA CTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF10 ( XM_005248264.4 ) cDNA ORF clone, Homo sapiens(human) -> XP_005248321.1 Homo sapiens fibroblast growth factor 10 (FGF10), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu26758
Clone ID Related Accession (Same CDS sequence)	XM_005248264.3 , XM_005248264.4 , NM_004465.1 , XM_005248264.2 , NM_004465.2
Accession Version	XM_005248264.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	fibroblast growth factor 10 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000005.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_005248264.3. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTGGAAAT GGATACTGAC ACATTGTGCC TCAGCCTTTC CCCACCTGCC CGGCTGCTGC 
TGCTGCTGCT TTTTGTTGCT GTTCTTGGTG TCTTCCGTCC CTGTCACCTG CCAAGCCCTT 
GGTCAGGACA TGGTGTCACC AGAGGCCACC AACTCTTCTT CCTCCTCCTT CTCCTCTCCT 
TCCAGCGCGG GAAGGCATGT GCGGAGCTAC AATCACCTTC AAGGAGATGT CCGCTGGAGA 
AAGCTATTCT CTTTCACCAA GTACTTTCTC AAGATTGAGA AGAACGGGAA GGTCAGCGGG 
ACCAAGAAGG AGAACTGCCC GTACAGCATC CTGGAGATAA CATCAGTAGA AATCGGAGTT 
GTTGCCGTCA AAGCCATTAA CAGCAACTAT TACTTAGCCA TGAACAAGAA GGGGAAACTC 
TATGGCTCAA AAGAATTTAA CAATGACTGT AAGCTGAAGG AGAGGATAGA GGAAAATGGA 
TACAATACCT ATGCATCATT TAACTGGCAG CATAATGGGA GGCAAATGTA TGTGGCATTG 
AATGGAAAAG GAGCTCCAAG GAGAGGACAG AAAACACGAA GGAAAAACAC CTCTGCTCAC 
TTTCTTCCAA TGGTGGTACA CTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005248321.1
CDS	934..1560
Translation	MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS

Target ORF information:

RefSeq Version	XM_005248264.4
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 10 (FGF10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005248264.4

ORF Insert Sequence:

ATGTGGAAAT GGATACTGAC ACATTGTGCC TCAGCCTTTC CCCACCTGCC CGGCTGCTGC 
TGCTGCTGCT TTTTGTTGCT GTTCTTGGTG TCTTCCGTCC CTGTCACCTG CCAAGCCCTT 
GGTCAGGACA TGGTGTCACC AGAGGCCACC AACTCTTCTT CCTCCTCCTT CTCCTCTCCT 
TCCAGCGCGG GAAGGCATGT GCGGAGCTAC AATCACCTTC AAGGAGATGT CCGCTGGAGA 
AAGCTATTCT CTTTCACCAA GTACTTTCTC AAGATTGAGA AGAACGGGAA GGTCAGCGGG 
ACCAAGAAGG AGAACTGCCC GTACAGCATC CTGGAGATAA CATCAGTAGA AATCGGAGTT 
GTTGCCGTCA AAGCCATTAA CAGCAACTAT TACTTAGCCA TGAACAAGAA GGGGAAACTC 
TATGGCTCAA AAGAATTTAA CAATGACTGT AAGCTGAAGG AGAGGATAGA GGAAAATGGA 
TACAATACCT ATGCATCATT TAACTGGCAG CATAATGGGA GGCAAATGTA TGTGGCATTG 
AATGGAAAAG GAGCTCCAAG GAGAGGACAG AAAACACGAA GGAAAAACAC CTCTGCTCAC 
TTTCTTCCAA TGGTGGTACA CTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF10 ( XM_005248264.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005248321.1 Homo sapiens fibroblast growth factor 10 (FGF10), transcript variant X1, mRNA.

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CloneID	OHu26758
Clone ID Related Accession (Same CDS sequence)	XM_005248264.3 , XM_005248264.4 , NM_004465.1 , XM_005248264.2 , NM_004465.2
Accession Version	XM_005248264.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 627bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	fibroblast growth factor 10 isoform X1
Comment

ATGTGGAAAT GGATACTGAC ACATTGTGCC TCAGCCTTTC CCCACCTGCC CGGCTGCTGC 
TGCTGCTGCT TTTTGTTGCT GTTCTTGGTG TCTTCCGTCC CTGTCACCTG CCAAGCCCTT 
GGTCAGGACA TGGTGTCACC AGAGGCCACC AACTCTTCTT CCTCCTCCTT CTCCTCTCCT 
TCCAGCGCGG GAAGGCATGT GCGGAGCTAC AATCACCTTC AAGGAGATGT CCGCTGGAGA 
AAGCTATTCT CTTTCACCAA GTACTTTCTC AAGATTGAGA AGAACGGGAA GGTCAGCGGG 
ACCAAGAAGG AGAACTGCCC GTACAGCATC CTGGAGATAA CATCAGTAGA AATCGGAGTT 
GTTGCCGTCA AAGCCATTAA CAGCAACTAT TACTTAGCCA TGAACAAGAA GGGGAAACTC 
TATGGCTCAA AAGAATTTAA CAATGACTGT AAGCTGAAGG AGAGGATAGA GGAAAATGGA 
TACAATACCT ATGCATCATT TAACTGGCAG CATAATGGGA GGCAAATGTA TGTGGCATTG 
AATGGAAAAG GAGCTCCAAG GAGAGGACAG AAAACACGAA GGAAAAACAC CTCTGCTCAC 
TTTCTTCCAA TGGTGGTACA CTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005248321.1
Translation	MWKWILTHCASAFPHLPGCCCCCFLLLFLVSSVPVTCQALGQDMVSPEATNSSSSSFSSPSSAGRHVRSYNHLQGDVRWRKLFSFTKYFLKIEKNGKVSGTKKENCPYSILEITSVEIGVVAVKAINSNYYLAMNKKGKLYGSKEFNNDCKLKERIEENGYNTYASFNWQHNGRQMYVALNGKGAPRRGQKTRRKNTSAHFLPMVVHS

Target ORF information:

RefSeq Version	XM_005248264.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens fibroblast growth factor 10 (FGF10), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005248264.2

ORF Insert Sequence:

ATGTGGAAAT GGATACTGAC ACATTGTGCC TCAGCCTTTC CCCACCTGCC CGGCTGCTGC 
TGCTGCTGCT TTTTGTTGCT GTTCTTGGTG TCTTCCGTCC CTGTCACCTG CCAAGCCCTT 
GGTCAGGACA TGGTGTCACC AGAGGCCACC AACTCTTCTT CCTCCTCCTT CTCCTCTCCT 
TCCAGCGCGG GAAGGCATGT GCGGAGCTAC AATCACCTTC AAGGAGATGT CCGCTGGAGA 
AAGCTATTCT CTTTCACCAA GTACTTTCTC AAGATTGAGA AGAACGGGAA GGTCAGCGGG 
ACCAAGAAGG AGAACTGCCC GTACAGCATC CTGGAGATAA CATCAGTAGA AATCGGAGTT 
GTTGCCGTCA AAGCCATTAA CAGCAACTAT TACTTAGCCA TGAACAAGAA GGGGAAACTC 
TATGGCTCAA AAGAATTTAA CAATGACTGT AAGCTGAAGG AGAGGATAGA GGAAAATGGA 
TACAATACCT ATGCATCATT TAACTGGCAG CATAATGGGA GGCAAATGTA TGTGGCATTG 
AATGGAAAAG GAGCTCCAAG GAGAGGACAG AAAACACGAA GGAAAAACAC CTCTGCTCAC 
TTTCTTCCAA TGGTGGTACA CTCATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

New pathogenic variant in the FGF10 gene in the agenesis of lacrimal and salivary gland syndrome: Ophthalmological and genetic study.
Ophthalmic genetics39(1)125-128(2018 Jan-Feb)
Rodrigo MJ,Idoipe M,Izquierdo S,Satue M,Mateo A,Sanchez A,Garcia-Martin E,Pablo L

Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.
American journal of human genetics99(4)903-911(2016 Oct)
Ghoussaini M,French JD,Michailidou K,Nord S,Beesley J,Canisus S,Hillman KM,Kaufmann S,Sivakumaran H,Moradi Marjaneh M,Lee JS,Dennis J,Bolla MK,Wang Q,Dicks E,Milne RL,Hopper JL,Southey MC,Schmidt MK,Broeks A,Muir K,Lophatananon A,Fasching PA,Beckmann MW,Fletcher O,Johnson N,Sawyer EJ,Tomlinson I,Burwinkel B,Marme F,Gu?nel P,Truong T,Bojesen SE,Flyger H,Benitez J,Gonz?lez-Neira A,Alonso MR,Pita G,Neuhausen SL,Anton-Culver H,Brenner H,Arndt V,Meindl A,Schmutzler RK,Brauch H,Hamann U,Tessier DC,Vincent D,Nevanlinna H,Khan S,Matsuo K,Ito H,D?rk T,Bogdanova NV,Lindblom A,Margolin S,Mannermaa A,Kosma VM,,Wu AH,Van Den Berg D,Lambrechts D,Floris G,Chang-Claude J,Rudolph A,Radice P,Barile M,Couch FJ,Hallberg E,Giles GG,Haiman CA,Le Marchand L,Goldberg MS,Teo SH,Yip CH,Borresen-Dale AL,,Zheng W,Cai Q,Winqvist R,Pylk?s K,Andrulis IL,Devilee P,Tollenaar RA,Garc?a-Closas M,Figueroa J,Hall P,Czene K,Brand JS,Darabi H,Eriksson M,Hooning MJ,Koppert LB,Li J,Shu XO,Zheng Y,Cox A,Cross SS,Shah M,Rhenius V,Choi JY,Kang D,Hartman M,Chia KS,Kabisch M,Torres D,Luccarini C,Conroy DM,Jakubowska A,Lubinski J,Sangrajrang S,Brennan P,Olswold C,Slager S,Shen CY,Hou MF,Swerdlow A,Schoemaker MJ,Simard J,Pharoah PD,Kristensen V,Chenevix-Trench G,Easton DF,Dunning AM,Edwards SL

Fibroblast Growth Factor Ligand Dependent Proliferation and Chondrogenic Differentiation of Synovium-Derived Stem Cells and Concomitant Adaptation of Wnt/Mitogen-Activated Protein Kinase Signals.
Tissue engineering. Part A22(15-16)1036-46(2016 08)
Pizzute T,Li J,Zhang Y,Davis ME,Pei M

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FGF10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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