FGF4 cDNA ORF clone, Homo sapiens(Human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FGF4
Entrez Gene ID	2249
Full Name	fibroblast growth factor 4
Synonyms	FGF-4,HBGF-4,HST,HST-1,HSTF-1,HSTF1,K-FGF,KFGF
General protein information	Preferred Names fibroblast growth factor 4 Names fibroblast growth factor 4 fibroblast growth factor 4 splice isoform heparin secretory transforming protein 1 heparin-binding growth factor 4 human stomach cancer, transforming factor from FGF-related oncogene kaposi sarcoma oncogene oncogene HST transforming protein KS3
Gene Type	protein-coding
Organism	Homo sapiens(Human)
Genome	Chromosome: 11 Map Location: 11q13.3
Summary	The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its oncogenic transforming activity. This gene and FGF3, another oncogenic growth factor, are located closely on chromosome 11. Co-amplification of both genes was found in various kinds of human tumors. Studies on the mouse homolog suggested a function in bone morphogenesis and limb development through the sonic hedgehog (SHH) signaling pathway. [provided by RefSeq, Jul 2008].
Disorder MIM:	164980

mRNA and Protein(s)

mRNA	Protein	Name
XM_006718475.2	XP_006718538.1	fibroblast growth factor 4 isoform X1
NM_002007.3	NP_001998.1	fibroblast growth factor 4 precursor
NM_002007.4	NP_001998.1	fibroblast growth factor 4 precursor
XM_005273847.1	XP_005273904.1	fibroblast growth factor 4 isoform X1
NM_002007.2	NP_001998.1	fibroblast growth factor 4 precursor

Pathways from BioSystems

Homologies

	FGF4	XP_001100747.1
Xenopus tropicalis (tropical clawed frog)	fgf4	NP_001136294.1
Homo sapiens (human)	FGF4	NP_001998.1
Bos taurus (cattle)	FGF4	NP_001035695.2
Danio rerio (zebrafish)	fgf4	NP_571710.1
Pan troglodytes (chimpanzee)	FGF4	XP_001173970.1
Canis lupus familiaris (dog)	FGF4	XP_540801.2
Mus musculus (house mouse)	Fgf4	NP_034332.2
Rattus norvegicus (Norway rat)	Fgf4	NP_446261.1
Gallus gallus (chicken)	FGF4	NP_001026717.1

Gene Ontology
Bibliography

Related articles in PubMed

Association of Fibroblast Growth Factor Receptor 4 Genetic Polymorphisms With the Development of Uterine Cervical Cancer and Patient Prognosis.
Chen TH, Yang SF, Liu YF, Lin WL, Han CP, Wang PH
Reproductive sciences (Thousand Oaks, Calif.)25(1)86-93(2018 Jan)

The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells.
Shi H, Li Y, Feng G, Li L, Fang R, Wang Z, Qu J, Ding P, Zhang X, Ye L
Biochemical and biophysical research communications471(1)89-94(2016 Feb)

Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
Yasuda K, Torigoe T, Mariya T, Asano T, Kuroda T, Matsuzaki J, Ikeda K, Yamauchi M, Emori M, Asanuma H, Hasegawa T, Saito T, Hirohashi Y, Sato N
Laboratory investigation; a journal of technical methods and pathology94(12)1355-69(2014 Dec)

Increased FGF3 and FGF4 gene dosage is a risk factor for craniosynostosis.
Grillo L, Greco D, Pettinato R, Avola E, Potenza N, Castiglia L, Spalletta A, Amata S, Di Benedetto D, Luciano D, Romano C, Fichera M
Gene534(2)435-9(2014 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Thus, we conclude that the oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells. Therapeutically, HBXIP may serve as a novel target in breast cancer.
Title: The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells.

Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
Title: Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.

A de novo 290 kb interstitial duplication of chromosome 11q13.3 including the FGF3 and FGF4 genes.
Title: Increased FGF3 and FGF4 gene dosage is a risk factor for craniosynostosis.

Data show that the interaction between Artd1 and Sox2 is crucial for the first steps of the reprogramming process and that early expression of Fgf4 is an essential component for the successful generation of iPSCs.
Title: Artd1/Parp1 regulates reprogramming by transcriptional regulation of Fgf4 via Sox2 ADP-ribosylation.

In vivo stimulation of BT-474 cell growth by progesterone is associated with up-regulation of FGF4 which may promote tumor growth and maintenance.
Title: Differential expression of FGF family members in a progestin-dependent BT-474 human breast cancer xenograft model.

The following FGF4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FGF4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu16472	NM_002007.4 Latest version!	Homo sapiens fibroblast growth factor 4 (FGF4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16472	XM_006718475.2 Latest version!	Homo sapiens fibroblast growth factor 4 (FGF4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu45230	XM_005273847.1 Latest version!	Homo sapiens fibroblast growth factor 4 (FGF4), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
View Old Accession Versions >>
OHu16472	NM_002007.3	Homo sapiens fibroblast growth factor 4 (FGF4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu16472	NM_002007.2	Homo sapiens fibroblast growth factor 4 (FGF4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FGF4 ( NM_002007.3 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001998.1 Homo sapiens fibroblast growth factor 4 (FGF4), mRNA.

Price & Availability↑

CloneID	OHu16472
Clone ID Related Accession (Same CDS sequence)	XM_006718475.2 , NM_002007.3 , NM_002007.4 , NM_002007.2
Accession Version	NM_002007.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-10
Organism	Homo sapiens(human)
Product	fibroblast growth factor 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M17446.1, CN429959.1, AW340506.1, AP001888.4, BF510715.1 and AA974433.1. On Aug 5, 2017 this sequence version replaced NM_002007.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M17446.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END##

ATGTCGGGGC CCGGGACGGC CGCGGTAGCG CTGCTCCCGG CGGTCCTGCT GGCCTTGCTG 
GCGCCCTGGG CGGGCCGAGG GGGCGCCGCC GCACCCACTG CACCCAACGG CACGCTGGAG 
GCCGAGCTGG AGCGCCGCTG GGAGAGCCTG GTGGCGCTCT CGTTGGCGCG CCTGCCGGTG 
GCAGCGCAGC CCAAGGAGGC GGCCGTCCAG AGCGGCGCCG GCGACTACCT GCTGGGCATC 
AAGCGGCTGC GGCGGCTCTA CTGCAACGTG GGCATCGGCT TCCACCTCCA GGCGCTCCCC 
GACGGCCGCA TCGGCGGCGC GCACGCGGAC ACCCGCGACA GCCTGCTGGA GCTCTCGCCC 
GTGGAGCGGG GCGTGGTGAG CATCTTCGGC GTGGCCAGCC GGTTCTTCGT GGCCATGAGC 
AGCAAGGGCA AGCTCTATGG CTCGCCCTTC TTCACCGATG AGTGCACGTT CAAGGAGATT 
CTCCTTCCCA ACAACTACAA CGCCTACGAG TCCTACAAGT ACCCCGGCAT GTTCATCGCC 
CTGAGCAAGA ATGGGAAGAC CAAGAAGGGG AACCGAGTGT CGCCCACCAT GAAGGTCACC 
CACTTCCTCC CCAGGCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001998.1
CDS	320..940
Translation	MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL

Target ORF information:

RefSeq Version	NM_002007.3
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 4 (FGF4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002007.3

ORF Insert Sequence:

ATGTCGGGGC CCGGGACGGC CGCGGTAGCG CTGCTCCCGG CGGTCCTGCT GGCCTTGCTG 
GCGCCCTGGG CGGGCCGAGG GGGCGCCGCC GCACCCACTG CACCCAACGG CACGCTGGAG 
GCCGAGCTGG AGCGCCGCTG GGAGAGCCTG GTGGCGCTCT CGTTGGCGCG CCTGCCGGTG 
GCAGCGCAGC CCAAGGAGGC GGCCGTCCAG AGCGGCGCCG GCGACTACCT GCTGGGCATC 
AAGCGGCTGC GGCGGCTCTA CTGCAACGTG GGCATCGGCT TCCACCTCCA GGCGCTCCCC 
GACGGCCGCA TCGGCGGCGC GCACGCGGAC ACCCGCGACA GCCTGCTGGA GCTCTCGCCC 
GTGGAGCGGG GCGTGGTGAG CATCTTCGGC GTGGCCAGCC GGTTCTTCGT GGCCATGAGC 
AGCAAGGGCA AGCTCTATGG CTCGCCCTTC TTCACCGATG AGTGCACGTT CAAGGAGATT 
CTCCTTCCCA ACAACTACAA CGCCTACGAG TCCTACAAGT ACCCCGGCAT GTTCATCGCC 
CTGAGCAAGA ATGGGAAGAC CAAGAAGGGG AACCGAGTGT CGCCCACCAT GAAGGTCACC 
CACTTCCTCC CCAGGCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF4 ( NM_002007.4 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001998.1 Homo sapiens fibroblast growth factor 4 (FGF4), mRNA.

Price & Availability↑

CloneID	OHu16472
Clone ID Related Accession (Same CDS sequence)	XM_006718475.2 , NM_002007.3 , NM_002007.4 , NM_002007.2
Accession Version	NM_002007.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	fibroblast growth factor 4 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M17446.1, CN429959.1, AW340506.1, AP001888.4, BF510715.1 and AA974433.1. On Nov 23, 2018 this sequence version replaced NM_002007.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M17446.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000168712.3/ ENSP00000168712.1 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGTCGGGGC CCGGGACGGC CGCGGTAGCG CTGCTCCCGG CGGTCCTGCT GGCCTTGCTG 
GCGCCCTGGG CGGGCCGAGG GGGCGCCGCC GCACCCACTG CACCCAACGG CACGCTGGAG 
GCCGAGCTGG AGCGCCGCTG GGAGAGCCTG GTGGCGCTCT CGTTGGCGCG CCTGCCGGTG 
GCAGCGCAGC CCAAGGAGGC GGCCGTCCAG AGCGGCGCCG GCGACTACCT GCTGGGCATC 
AAGCGGCTGC GGCGGCTCTA CTGCAACGTG GGCATCGGCT TCCACCTCCA GGCGCTCCCC 
GACGGCCGCA TCGGCGGCGC GCACGCGGAC ACCCGCGACA GCCTGCTGGA GCTCTCGCCC 
GTGGAGCGGG GCGTGGTGAG CATCTTCGGC GTGGCCAGCC GGTTCTTCGT GGCCATGAGC 
AGCAAGGGCA AGCTCTATGG CTCGCCCTTC TTCACCGATG AGTGCACGTT CAAGGAGATT 
CTCCTTCCCA ACAACTACAA CGCCTACGAG TCCTACAAGT ACCCCGGCAT GTTCATCGCC 
CTGAGCAAGA ATGGGAAGAC CAAGAAGGGG AACCGAGTGT CGCCCACCAT GAAGGTCACC 
CACTTCCTCC CCAGGCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001998.1
CDS	258..878
Translation	MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL

Target ORF information:

RefSeq Version	NM_002007.4
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 4 (FGF4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002007.4

ORF Insert Sequence:

ATGTCGGGGC CCGGGACGGC CGCGGTAGCG CTGCTCCCGG CGGTCCTGCT GGCCTTGCTG 
GCGCCCTGGG CGGGCCGAGG GGGCGCCGCC GCACCCACTG CACCCAACGG CACGCTGGAG 
GCCGAGCTGG AGCGCCGCTG GGAGAGCCTG GTGGCGCTCT CGTTGGCGCG CCTGCCGGTG 
GCAGCGCAGC CCAAGGAGGC GGCCGTCCAG AGCGGCGCCG GCGACTACCT GCTGGGCATC 
AAGCGGCTGC GGCGGCTCTA CTGCAACGTG GGCATCGGCT TCCACCTCCA GGCGCTCCCC 
GACGGCCGCA TCGGCGGCGC GCACGCGGAC ACCCGCGACA GCCTGCTGGA GCTCTCGCCC 
GTGGAGCGGG GCGTGGTGAG CATCTTCGGC GTGGCCAGCC GGTTCTTCGT GGCCATGAGC 
AGCAAGGGCA AGCTCTATGG CTCGCCCTTC TTCACCGATG AGTGCACGTT CAAGGAGATT 
CTCCTTCCCA ACAACTACAA CGCCTACGAG TCCTACAAGT ACCCCGGCAT GTTCATCGCC 
CTGAGCAAGA ATGGGAAGAC CAAGAAGGGG AACCGAGTGT CGCCCACCAT GAAGGTCACC 
CACTTCCTCC CCAGGCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF4 ( NM_002007.2 ) cDNA ORF clone, Homo sapiens(Human) -> NP_001998.1 Homo sapiens fibroblast growth factor 4 (FGF4), mRNA.

Price & Availability↑

CloneID	OHu16472
Clone ID Related Accession (Same CDS sequence)	XM_006718475.2 , NM_002007.3 , NM_002007.4 , NM_002007.2
Accession Version	NM_002007.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-04-08
Organism	Homo sapiens(Human)
Product	fibroblast growth factor 4 precursor
Comment	REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from M17446.1, CN429959.1 and AW340506.1. On Aug 13, 2008 this sequence version replaced NM_002007.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M17446.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2148093 [ECO:0000350] ##Evidence-Data-END##

ATGTCGGGGC CCGGGACGGC CGCGGTAGCG CTGCTCCCGG CGGTCCTGCT GGCCTTGCTG 
GCGCCCTGGG CGGGCCGAGG GGGCGCCGCC GCACCCACTG CACCCAACGG CACGCTGGAG 
GCCGAGCTGG AGCGCCGCTG GGAGAGCCTG GTGGCGCTCT CGTTGGCGCG CCTGCCGGTG 
GCAGCGCAGC CCAAGGAGGC GGCCGTCCAG AGCGGCGCCG GCGACTACCT GCTGGGCATC 
AAGCGGCTGC GGCGGCTCTA CTGCAACGTG GGCATCGGCT TCCACCTCCA GGCGCTCCCC 
GACGGCCGCA TCGGCGGCGC GCACGCGGAC ACCCGCGACA GCCTGCTGGA GCTCTCGCCC 
GTGGAGCGGG GCGTGGTGAG CATCTTCGGC GTGGCCAGCC GGTTCTTCGT GGCCATGAGC 
AGCAAGGGCA AGCTCTATGG CTCGCCCTTC TTCACCGATG AGTGCACGTT CAAGGAGATT 
CTCCTTCCCA ACAACTACAA CGCCTACGAG TCCTACAAGT ACCCCGGCAT GTTCATCGCC 
CTGAGCAAGA ATGGGAAGAC CAAGAAGGGG AACCGAGTGT CGCCCACCAT GAAGGTCACC 
CACTTCCTCC CCAGGCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001998.1
CDS	320..940
Translation	MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL

Target ORF information:

RefSeq Version	NM_002007.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens fibroblast growth factor 4 (FGF4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002007.2

ORF Insert Sequence:

ATGTCGGGGC CCGGGACGGC CGCGGTAGCG CTGCTCCCGG CGGTCCTGCT GGCCTTGCTG 
GCGCCCTGGG CGGGCCGAGG GGGCGCCGCC GCACCCACTG CACCCAACGG CACGCTGGAG 
GCCGAGCTGG AGCGCCGCTG GGAGAGCCTG GTGGCGCTCT CGTTGGCGCG CCTGCCGGTG 
GCAGCGCAGC CCAAGGAGGC GGCCGTCCAG AGCGGCGCCG GCGACTACCT GCTGGGCATC 
AAGCGGCTGC GGCGGCTCTA CTGCAACGTG GGCATCGGCT TCCACCTCCA GGCGCTCCCC 
GACGGCCGCA TCGGCGGCGC GCACGCGGAC ACCCGCGACA GCCTGCTGGA GCTCTCGCCC 
GTGGAGCGGG GCGTGGTGAG CATCTTCGGC GTGGCCAGCC GGTTCTTCGT GGCCATGAGC 
AGCAAGGGCA AGCTCTATGG CTCGCCCTTC TTCACCGATG AGTGCACGTT CAAGGAGATT 
CTCCTTCCCA ACAACTACAA CGCCTACGAG TCCTACAAGT ACCCCGGCAT GTTCATCGCC 
CTGAGCAAGA ATGGGAAGAC CAAGAAGGGG AACCGAGTGT CGCCCACCAT GAAGGTCACC 
CACTTCCTCC CCAGGCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF4 ( XM_006718475.2 ) cDNA ORF clone, Homo sapiens(Human) -> XP_006718538.1 Homo sapiens fibroblast growth factor 4 (FGF4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu16472
Clone ID Related Accession (Same CDS sequence)	XM_006718475.2 , NM_002007.3 , NM_002007.4 , NM_002007.2
Accession Version	XM_006718475.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 621bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-11
Organism	Homo sapiens(Human)
Product	fibroblast growth factor 4 isoform X1
Comment

ATGTCGGGGC CCGGGACGGC CGCGGTAGCG CTGCTCCCGG CGGTCCTGCT GGCCTTGCTG 
GCGCCCTGGG CGGGCCGAGG GGGCGCCGCC GCACCCACTG CACCCAACGG CACGCTGGAG 
GCCGAGCTGG AGCGCCGCTG GGAGAGCCTG GTGGCGCTCT CGTTGGCGCG CCTGCCGGTG 
GCAGCGCAGC CCAAGGAGGC GGCCGTCCAG AGCGGCGCCG GCGACTACCT GCTGGGCATC 
AAGCGGCTGC GGCGGCTCTA CTGCAACGTG GGCATCGGCT TCCACCTCCA GGCGCTCCCC 
GACGGCCGCA TCGGCGGCGC GCACGCGGAC ACCCGCGACA GCCTGCTGGA GCTCTCGCCC 
GTGGAGCGGG GCGTGGTGAG CATCTTCGGC GTGGCCAGCC GGTTCTTCGT GGCCATGAGC 
AGCAAGGGCA AGCTCTATGG CTCGCCCTTC TTCACCGATG AGTGCACGTT CAAGGAGATT 
CTCCTTCCCA ACAACTACAA CGCCTACGAG TCCTACAAGT ACCCCGGCAT GTTCATCGCC 
CTGAGCAAGA ATGGGAAGAC CAAGAAGGGG AACCGAGTGT CGCCCACCAT GAAGGTCACC 
CACTTCCTCC CCAGGCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_006718538.1
Translation	MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDSLLELSPVERGVVSIFGVASRFFVAMSSKGKLYGSPFFTDECTFKEILLPNNYNAYESYKYPGMFIALSKNGKTKKGNRVSPTMKVTHFLPRL

Target ORF information:

RefSeq Version	XM_006718475.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens fibroblast growth factor 4 (FGF4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_006718475.2

ORF Insert Sequence:

ATGTCGGGGC CCGGGACGGC CGCGGTAGCG CTGCTCCCGG CGGTCCTGCT GGCCTTGCTG 
GCGCCCTGGG CGGGCCGAGG GGGCGCCGCC GCACCCACTG CACCCAACGG CACGCTGGAG 
GCCGAGCTGG AGCGCCGCTG GGAGAGCCTG GTGGCGCTCT CGTTGGCGCG CCTGCCGGTG 
GCAGCGCAGC CCAAGGAGGC GGCCGTCCAG AGCGGCGCCG GCGACTACCT GCTGGGCATC 
AAGCGGCTGC GGCGGCTCTA CTGCAACGTG GGCATCGGCT TCCACCTCCA GGCGCTCCCC 
GACGGCCGCA TCGGCGGCGC GCACGCGGAC ACCCGCGACA GCCTGCTGGA GCTCTCGCCC 
GTGGAGCGGG GCGTGGTGAG CATCTTCGGC GTGGCCAGCC GGTTCTTCGT GGCCATGAGC 
AGCAAGGGCA AGCTCTATGG CTCGCCCTTC TTCACCGATG AGTGCACGTT CAAGGAGATT 
CTCCTTCCCA ACAACTACAA CGCCTACGAG TCCTACAAGT ACCCCGGCAT GTTCATCGCC 
CTGAGCAAGA ATGGGAAGAC CAAGAAGGGG AACCGAGTGT CGCCCACCAT GAAGGTCACC 
CACTTCCTCC CCAGGCTGTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FGF4 ( XM_005273847.1 ) cDNA ORF clone, Homo sapiens(Human) -> XP_005273904.1 Homo sapiens fibroblast growth factor 4 (FGF4), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu45230
Clone ID Related Accession (Same CDS sequence)	XM_005273847.1
Accession Version	XM_005273847.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 357bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	fibroblast growth factor 4 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000011.10) annotated using gene prediction method: Gnomon, supported by mRNA evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGTCGGGGC CCGGGACGGC CGCGGTAGCG CTGCTCCCGG CGGTCCTGCT GGCCTTGCTG 
GCGCCCTGGG CGGGCCGAGG GGGCGCCGCC GCACCCACTG CACCCAACGG CACGCTGGAG 
GCCGAGCTGG AGCGCCGCTG GGAGAGCCTG GTGGCGCTCT CGTTGGCGCG CCTGCCGGTG 
GCAGCGCAGC CCAAGGAGGC GGCCGTCCAG AGCGGCGCCG GCGACTACCT GCTGGGCATC 
AAGCGGCTGC GGCGGCTCTA CTGCAACGTG GGCATCGGCT TCCACCTCCA GGCGCTCCCC 
GACGGCCGCA TCGGCGGCGC GCACGCGGAC ACCCGCGACA CCCTTCTTCA CCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005273904.1
CDS	81..437
Translation	MSGPGTAAVALLPAVLLALLAPWAGRGGAAAPTAPNGTLEAELERRWESLVALSLARLPVAAQPKEAAVQSGAGDYLLGIKRLRRLYCNVGIGFHLQALPDGRIGGAHADTRDTLLHR

Target ORF information:

RefSeq Version	XM_005273847.1
Organism	Homo sapiens(human)
Definition	Homo sapiens fibroblast growth factor 4 (FGF4), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005273847.1

ORF Insert Sequence:

ATGTCGGGGC CCGGGACGGC CGCGGTAGCG CTGCTCCCGG CGGTCCTGCT GGCCTTGCTG 
GCGCCCTGGG CGGGCCGAGG GGGCGCCGCC GCACCCACTG CACCCAACGG CACGCTGGAG 
GCCGAGCTGG AGCGCCGCTG GGAGAGCCTG GTGGCGCTCT CGTTGGCGCG CCTGCCGGTG 
GCAGCGCAGC CCAAGGAGGC GGCCGTCCAG AGCGGCGCCG GCGACTACCT GCTGGGCATC 
AAGCGGCTGC GGCGGCTCTA CTGCAACGTG GGCATCGGCT TCCACCTCCA GGCGCTCCCC 
GACGGCCGCA TCGGCGGCGC GCACGCGGAC ACCCGCGACA CCCTTCTTCA CCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Association of Fibroblast Growth Factor Receptor 4 Genetic Polymorphisms With the Development of Uterine Cervical Cancer and Patient Prognosis.
Reproductive sciences (Thousand Oaks, Calif.)25(1)86-93(2018 Jan)
Chen TH,Yang SF,Liu YF,Lin WL,Han CP,Wang PH

The oncoprotein HBXIP up-regulates FGF4 through activating transcriptional factor Sp1 to promote the migration of breast cancer cells.
Biochemical and biophysical research communications471(1)89-94(2016 Feb)
Shi H,Li Y,Feng G,Li L,Fang R,Wang Z,Qu J,Ding P,Zhang X,Ye L

Fibroblasts induce expression of FGF4 in ovarian cancer stem-like cells/cancer-initiating cells and upregulate their tumor initiation capacity.
Laboratory investigation; a journal of technical methods and pathology94(12)1355-69(2014 Dec)
Yasuda K,Torigoe T,Mariya T,Asano T,Kuroda T,Matsuzaki J,Ikeda K,Yamauchi M,Emori M,Asanuma H,Hasegawa T,Saito T,Hirohashi Y,Sato N

Increased FGF3 and FGF4 gene dosage is a risk factor for craniosynostosis.
Gene534(2)435-9(2014 Jan)
Grillo L,Greco D,Pettinato R,Avola E,Potenza N,Castiglia L,Spalletta A,Amata S,Di Benedetto D,Luciano D,Romano C,Fichera M

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FGF4 cDNA ORF clone, Homo sapiens(Human)

Gene

Clones

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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