FCN1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FCN1
Entrez Gene ID	2219
Full Name	ficolin 1
Synonyms	FCNM
General protein information	Preferred Names ficolin 1 Names ficolin-1 M-ficolin ficolin (collagen/fibrinogen domain-containing) 1 ficolin-A ficolin-alpha
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q34.3
Summary	The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008].
Disorder MIM:	601252

mRNA and Protein(s)

mRNA	Protein	Name
NM_002003.3	NP_001994.2	ficolin-1 precursor
NM_002003.4	NP_001994.2	ficolin-1 precursor
NM_002003.5	NP_001994.2	ficolin-1 precursor

Pathways from BioSystems

Homologies

	FCN1	XP_001098002.1
Bos taurus (cattle)	FCN1	NP_001010996.1
Xenopus tropicalis (tropical clawed frog)	LOC100495637	XP_004917595.1
Pan troglodytes (chimpanzee)	FCN1	XP_001170643.1
Rattus norvegicus (Norway rat)	Fcnb	NP_446086.1
Gallus gallus (chicken)	FCN2	XP_004945800.1
Drosophila melanogaster (fruit fly)	CG5550	NP_611160.2
Xenopus tropicalis (tropical clawed frog)	MGC108470	XP_004917597.1
Xenopus tropicalis (tropical clawed frog)	MGC107908	XP_004917596.1
Canis lupus familiaris (dog)	LOC608247	XP_850307.1
Mus musculus (house mouse)	Fcnb	NP_034320.1
Xenopus tropicalis (tropical clawed frog)	LOC100491028	XP_002943934.2
Homo sapiens (human)	FCN1	NP_001994.2

Gene Ontology
Bibliography

Related articles in PubMed

M-ficolin is present in Aspergillus fumigatus infected lung and modulates epithelial cell immune responses elicited by fungal cell wall polysaccharides.
Jensen K, Lund KP, Christensen KB, Holm AT, Dubey LK, Moeller JB, Jepsen CS, Schlosser A, Galg?czy L, Thiel S, Holmskov U, Sorensen GL
Virulence8(8)1870-1879(2017 Nov)

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Glavey SV, Naba A, Manier S, Clauser K, Tahri S, Park J, Reagan MR, Moschetta M, Mishima Y, Gambella M, Rocci A, Sacco A, O'Dwyer ME, Asara JM, Palumbo A, Roccaro AM, Hynes RO, Ghobrial IM
Leukemia31(11)2426-2434(2017 Nov)

FCN1 (M-ficolin), which directly associates with immunoglobulin G1, is a molecular target of intravenous immunoglobulin therapy for Kawasaki disease.
Okuzaki D, Ota K, Takatsuki SI, Akiyoshi Y, Naoi K, Yabuta N, Saji T, Nojima H
Scientific reports7(1)11334(2017 Sep)

Association of Serum Levels of Pentraxin-3, M-ficolin, and Surfactant Protein A with the Severity of Ischemic Stroke.
Kouchaki E, Babamohammadi A, Nikoueinejad H, Sehat M
Iranian journal of allergy, asthma, and immunology16(2)140-146(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

systemic lupus erythematosus patients with high ficolin-1 plasma levels had an increased risk of end-stage renal disease; there was no significant association between ficolin-1 and ficolin-3 with lupus nephritis
Title: Plasma ficolin levels and risk of nephritis in Danish patients with systemic lupus erythematosus.

in northeastern Brazilian children and adolescents, FCN1 rs1071583 SNP was correlated with earlier age of type 1 diabetes mellitus (T1D) diagnosis; the SNP combination rs2989727 and rs1071583 was involved with T1D protection
Title: Polymorphism in ficolin-1 (FCN1) gene is associated with an earlier onset of type 1 diabetes mellitus in children and adolescents from northeast Brazil.

Ficolin-1 could provide an alternative receptor-mediated mechanism for enhancing Ebola Virus infection, thereby contributing to viral subversion of the host innate immune system.
Title: Enhancement of Ebola Virus Infection via Ficolin-1 Interaction with the Mucin Domain of GP Glycoprotein.

Ficolin-1 was decreased in patients compared with controls measured at 6 h (median 0.13 vs 0.33 mug/ml, respectively, p < 0.0001). At 48 h, ficolin-1 was significantly higher
Title: Early ficolin-1 is a sensitive prognostic marker for functional outcome in ischemic stroke.

Data indicate differences in the plasma concentrations of collectin liver 1 and collectin kidney 1, M-ficolin and H-ficol in systemic lupus erythematosus (SLE) patients compared to a group of healthy controls.
Title: Collectin liver 1 and collectin kidney 1 and other complement-associated pattern recognition molecules in systemic lupus erythematosus.

The following FCN1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FCN1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu03785	NM_002003.5 Latest version!	Homo sapiens ficolin 1 (FCN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu03785	NM_002003.3	Homo sapiens ficolin (collagen/fibrinogen domain containing) 1 (FCN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu03785	NM_002003.4	Homo sapiens ficolin 1 (FCN1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FCN1 ( NM_002003.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001994.2 Homo sapiens ficolin (collagen/fibrinogen domain containing) 1 (FCN1), mRNA.

Price & Availability↑

CloneID	OHu03785
Clone ID Related Accession (Same CDS sequence)	NM_002003.3 , NM_002003.4 , NM_002003.5
Accession Version	NM_002003.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	ficolin-1 precursor
Comment

ATGGAGCTGA GTGGAGCCAC CATGGCCCGG GGGCTCGCTG TCCTGCTAGT CTTGTTCCTG 
CATATCAAGA ACCTGCCTGC CCAGGCTGCG GACACATGTC CAGAGGTGAA GGTGGTGGGC 
CTGGAGGGCT CTGACAAGCT CACCATTCTC CGAGGCTGCC CGGGGCTGCC CGGGGCCCCA 
GGGCCAAAGG GAGAGGCAGG TGTCATTGGA GAGAGAGGAG AACGCGGTCT CCCTGGAGCC 
CCTGGAAAGG CAGGACCAGT GGGGCCCAAA GGAGACCGAG GAGAGAAGGG GATGCGTGGA 
GAGAAAGGAG ACGCTGGGCA GTCTCAGTCG TGTGCGACAG GCCCACGCAA CTGCAAGGAC 
CTGCTAGACC GGGGGTATTT CCTGAGCGGC TGGCACACCA TCTACCTGCC CGACTGCCGG 
CCCCTGACTG TGCTCTGTGA CATGGACACG GACGGAGGGG GCTGGACCGT TTTCCAGCGG 
AGGATGGATG GCTCTGTGGA CTTCTATCGG GACTGGGCCG CATACAAGCA GGGCTTCGGC 
AGTCAGCTGG GGGAGTTCTG GCTGGGGAAT GACAACATCC ACGCCCTGAC TGCCCAGGGA 
AGCAGCGAGC TCCGTGTAGA CCTGGTGGAC TTTGAGGGCA ACCACCAGTT TGCTAAGTAC 
AAATCATTCA AGGTGGCTGA CGAGGCAGAG AAGTACAAGC TGGTACTGGG AGCCTTTGTC 
GGGGGCAGTG CGGGTAATTC TCTAACGGGC CACAACAACA ACTTCTTCTC CACCAAAGAC 
CAAGACAATG ATGTGAGTTC TTCGAATTGT GCTGAGAAGT TCCAAGGAGC CTGGTGGTAC 
GCCGACTGTC ATGCTTCAAA CCTCAATGGT CTCTACCTCA TGGGACCCCA TGAGAGCTAT 
GCCAATGGTA TCAACTGGAG TGCGGCGAAG GGGTACAAAT ATAGCTACAA GGTGTCAGAG 
ATGAAGGTGC GGCCCGCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001994.2
Translation	MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA

Target ORF information:

RefSeq Version	NM_002003.3
Organism	Homo sapiens(Human)
Definition	Homo sapiens ficolin (collagen/fibrinogen domain containing) 1 (FCN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002003.3

ORF Insert Sequence:

ATGGAGCTGA GTGGAGCCAC CATGGCCCGG GGGCTCGCTG TCCTGCTAGT CTTGTTCCTG 
CATATCAAGA ACCTGCCTGC CCAGGCTGCG GACACATGTC CAGAGGTGAA GGTGGTGGGC 
CTGGAGGGCT CTGACAAGCT CACCATTCTC CGAGGCTGCC CGGGGCTGCC CGGGGCCCCA 
GGGCCAAAGG GAGAGGCAGG TGTCATTGGA GAGAGAGGAG AACGCGGTCT CCCTGGAGCC 
CCTGGAAAGG CAGGACCAGT GGGGCCCAAA GGAGACCGAG GAGAGAAGGG GATGCGTGGA 
GAGAAAGGAG ACGCTGGGCA GTCTCAGTCG TGTGCGACAG GCCCACGCAA CTGCAAGGAC 
CTGCTAGACC GGGGGTATTT CCTGAGCGGC TGGCACACCA TCTACCTGCC CGACTGCCGG 
CCCCTGACTG TGCTCTGTGA CATGGACACG GACGGAGGGG GCTGGACCGT TTTCCAGCGG 
AGGATGGATG GCTCTGTGGA CTTCTATCGG GACTGGGCCG CATACAAGCA GGGCTTCGGC 
AGTCAGCTGG GGGAGTTCTG GCTGGGGAAT GACAACATCC ACGCCCTGAC TGCCCAGGGA 
AGCAGCGAGC TCCGTGTAGA CCTGGTGGAC TTTGAGGGCA ACCACCAGTT TGCTAAGTAC 
AAATCATTCA AGGTGGCTGA CGAGGCAGAG AAGTACAAGC TGGTACTGGG AGCCTTTGTC 
GGGGGCAGTG CGGGTAATTC TCTAACGGGC CACAACAACA ACTTCTTCTC CACCAAAGAC 
CAAGACAATG ATGTGAGTTC TTCGAATTGT GCTGAGAAGT TCCAAGGAGC CTGGTGGTAC 
GCCGACTGTC ATGCTTCAAA CCTCAATGGT CTCTACCTCA TGGGACCCCA TGAGAGCTAT 
GCCAATGGTA TCAACTGGAG TGCGGCGAAG GGGTACAAAT ATAGCTACAA GGTGTCAGAG 
ATGAAGGTGC GGCCCGCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FCN1 ( NM_002003.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001994.2 Homo sapiens ficolin 1 (FCN1), mRNA.

Price & Availability↑

CloneID	OHu03785
Clone ID Related Accession (Same CDS sequence)	NM_002003.3 , NM_002003.4 , NM_002003.5
Accession Version	NM_002003.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	ficolin-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA813504.1, AK314867.1, BC020635.1, AL353611.19, AL603650.10 and AL833097.1. This sequence is a reference standard in the RefSeqGene project. On Jul 2, 2016 this sequence version replaced NM_002003.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020635.1, D83920.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2149004 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGAGCTGA GTGGAGCCAC CATGGCCCGG GGGCTCGCTG TCCTGCTAGT CTTGTTCCTG 
CATATCAAGA ACCTGCCTGC CCAGGCTGCG GACACATGTC CAGAGGTGAA GGTGGTGGGC 
CTGGAGGGCT CTGACAAGCT CACCATTCTC CGAGGCTGCC CGGGGCTGCC CGGGGCCCCA 
GGGCCAAAGG GAGAGGCAGG TGTCATTGGA GAGAGAGGAG AACGCGGTCT CCCTGGAGCC 
CCTGGAAAGG CAGGACCAGT GGGGCCCAAA GGAGACCGAG GAGAGAAGGG GATGCGTGGA 
GAGAAAGGAG ACGCTGGGCA GTCTCAGTCG TGTGCGACAG GCCCACGCAA CTGCAAGGAC 
CTGCTAGACC GGGGGTATTT CCTGAGCGGC TGGCACACCA TCTACCTGCC CGACTGCCGG 
CCCCTGACTG TGCTCTGTGA CATGGACACG GACGGAGGGG GCTGGACCGT TTTCCAGCGG 
AGGATGGATG GCTCTGTGGA CTTCTATCGG GACTGGGCCG CATACAAGCA GGGCTTCGGC 
AGTCAGCTGG GGGAGTTCTG GCTGGGGAAT GACAACATCC ACGCCCTGAC TGCCCAGGGA 
AGCAGCGAGC TCCGTGTAGA CCTGGTGGAC TTTGAGGGCA ACCACCAGTT TGCTAAGTAC 
AAATCATTCA AGGTGGCTGA CGAGGCAGAG AAGTACAAGC TGGTACTGGG AGCCTTTGTC 
GGGGGCAGTG CGGGTAATTC TCTAACGGGC CACAACAACA ACTTCTTCTC CACCAAAGAC 
CAAGACAATG ATGTGAGTTC TTCGAATTGT GCTGAGAAGT TCCAAGGAGC CTGGTGGTAC 
GCCGACTGTC ATGCTTCAAA CCTCAATGGT CTCTACCTCA TGGGACCCCA TGAGAGCTAT 
GCCAATGGTA TCAACTGGAG TGCGGCGAAG GGGTACAAAT ATAGCTACAA GGTGTCAGAG 
ATGAAGGTGC GGCCCGCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001994.2
CDS	133..1113
Translation	MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA

Target ORF information:

RefSeq Version	NM_002003.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ficolin 1 (FCN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002003.4

ORF Insert Sequence:

ATGGAGCTGA GTGGAGCCAC CATGGCCCGG GGGCTCGCTG TCCTGCTAGT CTTGTTCCTG 
CATATCAAGA ACCTGCCTGC CCAGGCTGCG GACACATGTC CAGAGGTGAA GGTGGTGGGC 
CTGGAGGGCT CTGACAAGCT CACCATTCTC CGAGGCTGCC CGGGGCTGCC CGGGGCCCCA 
GGGCCAAAGG GAGAGGCAGG TGTCATTGGA GAGAGAGGAG AACGCGGTCT CCCTGGAGCC 
CCTGGAAAGG CAGGACCAGT GGGGCCCAAA GGAGACCGAG GAGAGAAGGG GATGCGTGGA 
GAGAAAGGAG ACGCTGGGCA GTCTCAGTCG TGTGCGACAG GCCCACGCAA CTGCAAGGAC 
CTGCTAGACC GGGGGTATTT CCTGAGCGGC TGGCACACCA TCTACCTGCC CGACTGCCGG 
CCCCTGACTG TGCTCTGTGA CATGGACACG GACGGAGGGG GCTGGACCGT TTTCCAGCGG 
AGGATGGATG GCTCTGTGGA CTTCTATCGG GACTGGGCCG CATACAAGCA GGGCTTCGGC 
AGTCAGCTGG GGGAGTTCTG GCTGGGGAAT GACAACATCC ACGCCCTGAC TGCCCAGGGA 
AGCAGCGAGC TCCGTGTAGA CCTGGTGGAC TTTGAGGGCA ACCACCAGTT TGCTAAGTAC 
AAATCATTCA AGGTGGCTGA CGAGGCAGAG AAGTACAAGC TGGTACTGGG AGCCTTTGTC 
GGGGGCAGTG CGGGTAATTC TCTAACGGGC CACAACAACA ACTTCTTCTC CACCAAAGAC 
CAAGACAATG ATGTGAGTTC TTCGAATTGT GCTGAGAAGT TCCAAGGAGC CTGGTGGTAC 
GCCGACTGTC ATGCTTCAAA CCTCAATGGT CTCTACCTCA TGGGACCCCA TGAGAGCTAT 
GCCAATGGTA TCAACTGGAG TGCGGCGAAG GGGTACAAAT ATAGCTACAA GGTGTCAGAG 
ATGAAGGTGC GGCCCGCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FCN1 ( NM_002003.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001994.2 Homo sapiens ficolin 1 (FCN1), mRNA.

Price & Availability↑

CloneID	OHu03785
Clone ID Related Accession (Same CDS sequence)	NM_002003.3 , NM_002003.4 , NM_002003.5
Accession Version	NM_002003.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 981bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	ficolin-1 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA813504.1, AK314867.1, BC020635.1, AL353611.19, AL603650.10 and AL833097.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_002003.4. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC020635.1, SRR5189655.132754.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142670, SAMEA2149004 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000371806.4/ ENSP00000360871.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGAGCTGA GTGGAGCCAC CATGGCCCGG GGGCTCGCTG TCCTGCTAGT CTTGTTCCTG 
CATATCAAGA ACCTGCCTGC CCAGGCTGCG GACACATGTC CAGAGGTGAA GGTGGTGGGC 
CTGGAGGGCT CTGACAAGCT CACCATTCTC CGAGGCTGCC CGGGGCTGCC CGGGGCCCCA 
GGGCCAAAGG GAGAGGCAGG TGTCATTGGA GAGAGAGGAG AACGCGGTCT CCCTGGAGCC 
CCTGGAAAGG CAGGACCAGT GGGGCCCAAA GGAGACCGAG GAGAGAAGGG GATGCGTGGA 
GAGAAAGGAG ACGCTGGGCA GTCTCAGTCG TGTGCGACAG GCCCACGCAA CTGCAAGGAC 
CTGCTAGACC GGGGGTATTT CCTGAGCGGC TGGCACACCA TCTACCTGCC CGACTGCCGG 
CCCCTGACTG TGCTCTGTGA CATGGACACG GACGGAGGGG GCTGGACCGT TTTCCAGCGG 
AGGATGGATG GCTCTGTGGA CTTCTATCGG GACTGGGCCG CATACAAGCA GGGCTTCGGC 
AGTCAGCTGG GGGAGTTCTG GCTGGGGAAT GACAACATCC ACGCCCTGAC TGCCCAGGGA 
AGCAGCGAGC TCCGTGTAGA CCTGGTGGAC TTTGAGGGCA ACCACCAGTT TGCTAAGTAC 
AAATCATTCA AGGTGGCTGA CGAGGCAGAG AAGTACAAGC TGGTACTGGG AGCCTTTGTC 
GGGGGCAGTG CGGGTAATTC TCTAACGGGC CACAACAACA ACTTCTTCTC CACCAAAGAC 
CAAGACAATG ATGTGAGTTC TTCGAATTGT GCTGAGAAGT TCCAAGGAGC CTGGTGGTAC 
GCCGACTGTC ATGCTTCAAA CCTCAATGGT CTCTACCTCA TGGGACCCCA TGAGAGCTAT 
GCCAATGGTA TCAACTGGAG TGCGGCGAAG GGGTACAAAT ATAGCTACAA GGTGTCAGAG 
ATGAAGGTGC GGCCCGCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001994.2
CDS	42..1022
Translation	MELSGATMARGLAVLLVLFLHIKNLPAQAADTCPEVKVVGLEGSDKLTILRGCPGLPGAPGPKGEAGVIGERGERGLPGAPGKAGPVGPKGDRGEKGMRGEKGDAGQSQSCATGPRNCKDLLDRGYFLSGWHTIYLPDCRPLTVLCDMDTDGGGWTVFQRRMDGSVDFYRDWAAYKQGFGSQLGEFWLGNDNIHALTAQGSSELRVDLVDFEGNHQFAKYKSFKVADEAEKYKLVLGAFVGGSAGNSLTGHNNNFFSTKDQDNDVSSSNCAEKFQGAWWYADCHASNLNGLYLMGPHESYANGINWSAAKGYKYSYKVSEMKVRPA

Target ORF information:

RefSeq Version	NM_002003.5
Organism	Homo sapiens(human)
Definition	Homo sapiens ficolin 1 (FCN1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002003.5

ORF Insert Sequence:

ATGGAGCTGA GTGGAGCCAC CATGGCCCGG GGGCTCGCTG TCCTGCTAGT CTTGTTCCTG 
CATATCAAGA ACCTGCCTGC CCAGGCTGCG GACACATGTC CAGAGGTGAA GGTGGTGGGC 
CTGGAGGGCT CTGACAAGCT CACCATTCTC CGAGGCTGCC CGGGGCTGCC CGGGGCCCCA 
GGGCCAAAGG GAGAGGCAGG TGTCATTGGA GAGAGAGGAG AACGCGGTCT CCCTGGAGCC 
CCTGGAAAGG CAGGACCAGT GGGGCCCAAA GGAGACCGAG GAGAGAAGGG GATGCGTGGA 
GAGAAAGGAG ACGCTGGGCA GTCTCAGTCG TGTGCGACAG GCCCACGCAA CTGCAAGGAC 
CTGCTAGACC GGGGGTATTT CCTGAGCGGC TGGCACACCA TCTACCTGCC CGACTGCCGG 
CCCCTGACTG TGCTCTGTGA CATGGACACG GACGGAGGGG GCTGGACCGT TTTCCAGCGG 
AGGATGGATG GCTCTGTGGA CTTCTATCGG GACTGGGCCG CATACAAGCA GGGCTTCGGC 
AGTCAGCTGG GGGAGTTCTG GCTGGGGAAT GACAACATCC ACGCCCTGAC TGCCCAGGGA 
AGCAGCGAGC TCCGTGTAGA CCTGGTGGAC TTTGAGGGCA ACCACCAGTT TGCTAAGTAC 
AAATCATTCA AGGTGGCTGA CGAGGCAGAG AAGTACAAGC TGGTACTGGG AGCCTTTGTC 
GGGGGCAGTG CGGGTAATTC TCTAACGGGC CACAACAACA ACTTCTTCTC CACCAAAGAC 
CAAGACAATG ATGTGAGTTC TTCGAATTGT GCTGAGAAGT TCCAAGGAGC CTGGTGGTAC 
GCCGACTGTC ATGCTTCAAA CCTCAATGGT CTCTACCTCA TGGGACCCCA TGAGAGCTAT 
GCCAATGGTA TCAACTGGAG TGCGGCGAAG GGGTACAAAT ATAGCTACAA GGTGTCAGAG 
ATGAAGGTGC GGCCCGCCTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

M-ficolin is present in Aspergillus fumigatus infected lung and modulates epithelial cell immune responses elicited by fungal cell wall polysaccharides.
Virulence8(8)1870-1879(2017 Nov)
Jensen K,Lund KP,Christensen KB,Holm AT,Dubey LK,Moeller JB,Jepsen CS,Schlosser A,Galg?czy L,Thiel S,Holmskov U,Sorensen GL

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.
Leukemia31(11)2426-2434(2017 Nov)
Glavey SV,Naba A,Manier S,Clauser K,Tahri S,Park J,Reagan MR,Moschetta M,Mishima Y,Gambella M,Rocci A,Sacco A,O'Dwyer ME,Asara JM,Palumbo A,Roccaro AM,Hynes RO,Ghobrial IM

FCN1 (M-ficolin), which directly associates with immunoglobulin G1, is a molecular target of intravenous immunoglobulin therapy for Kawasaki disease.
Scientific reports7(1)11334(2017 Sep)
Okuzaki D,Ota K,Takatsuki SI,Akiyoshi Y,Naoi K,Yabuta N,Saji T,Nojima H

Association of Serum Levels of Pentraxin-3, M-ficolin, and Surfactant Protein A with the Severity of Ischemic Stroke.
ian journal of allergy, asthma, and immunology16(2)140-146(2017 Apr)
Kouchaki E,Babamohammadi A,Nikoueinejad H,Sehat M

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FCN1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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