FCER1A cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FCER1A
Entrez Gene ID	2205
Full Name	Fc fragment of IgE receptor Ia
Synonyms	FCE1A,FcERI
General protein information	Preferred Names Fc fragment of IgE receptor Ia Names high affinity immunoglobulin epsilon receptor subunit alpha Fc IgE receptor, alpha polypeptide Fc epsilon RI alpha-chain Fc epsilon receptor Ia Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide Fc-epsilon RI-alpha high affinity immunoglobulin epsilon receptor alpha-subunit igE Fc receptor subunit alpha immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q23.2
Summary	The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011].
Disorder MIM:	147140

mRNA and Protein(s)

mRNA	Protein	Name
NM_002001.3	NP_001992.1	high affinity immunoglobulin epsilon receptor subunit alpha precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	FCER1A	NP_001093780.1
Pan troglodytes (chimpanzee)	FCER1A	XP_001170670.2
	FCER1A	XP_001117218.2
Homo sapiens (human)	FCER1A	NP_001992.1
Canis lupus familiaris (dog)	FCER1A	NP_001104236.1
Mus musculus (house mouse)	Fcer1a	NP_034314.2
Rattus norvegicus (Norway rat)	Fcer1a	NP_036856.1

Gene Ontology
Bibliography

Related articles in PubMed

Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts Fc?RI interaction.
Jabs F, Plum M, Laursen NS, Jensen RK, M?lgaard B, Miehe M, Mandolesi M, Rauber MM, Pf?tzner W, Jakob T, M?bs C, Andersen GR, Spillner E
Nature communications9(1)7(2018 01)

Fc?R1? gene polymorphism shows association with high IgE and anti-Fc?R1? in Chronic Rhinosinusitis with Nasal Polyposis.
Dar SA, Rai G, Ansari MA, Akhter N, Gupta N, Sharma S, Haque S, Ramachandran VG, Wahid M, Rudramurthy SM, Chakrabarti A, Das S
Journal of cellular biochemistry(2017 Dec)

Autoreactive T cells in chronic spontaneous urticaria target the IgE Fc receptor I? subunit.
Auyeung P, Mittag D, Hodgkin PD, Harrison LC
The Journal of allergy and clinical immunology138(3)761-768.e4(2016 Sep)

Parameters determining the efficacy of CD32 to inhibit activation of Fc?RI in human basophils.
MacGlashan D Jr, Hamilton RG
The Journal of allergy and clinical immunology137(4)1256-1258.e11(2016 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Autoreactive CD4(+) T cells that target FcepsilonRIalpha were detected in most subjects with chronic spontaneous urticaria, with a cytokine secretion profile more typical of a TH1-cell response. Our findings suggest that measurement of T-cell as well as autoantibody responses to FcepsilonRIalpha could improve diagnostic accuracy in subjects with chronic spontaneous urticaria .
Title: Autoreactive T cells in chronic spontaneous urticaria target the IgE Fc receptor I? subunit.

Our results suggest that IL13 rs20541, IL4 rs2243250, ADRB2 rs1042713, and FCER1B rs569108, four SNPs with significant sole effect on asthma, interact to confer a higher risk for the disease in Chinese Han children.
Title: Four-locus gene interaction between IL13, IL4, FCER1B, and ADRB2 for asthma in Chinese Han children.

IgG2 and IgG3 are involved in recruiting CD32 to inhibit activation of FcepsilonRI in human basophils.
Title: Parameters determining the efficacy of CD32 to inhibit activation of Fc?RI in human basophils.

F-AFE containing anti-allergic phytochemicals, including arctigenin, inhibited the activation of the FceRI receptor induced by the antigenIgE complex
Title: Inhibitory effect of fermented Arctium lappa fruit extract on the IgE-mediated allergic response in RBL?2H3 cells.

Asthmatics with reduced lung function had a higher frequency of Lin(-) CD34(hi) CD117(int/hi) Fc epsilon RI(+) blood mast cell progenitors than asthmatics with normal lung function.
Title: Lin- CD34hi CD117int/hi Fc?RI+ cells in human blood constitute a rare population of mast cell progenitors.

The following FCER1A gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FCER1A cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu23672	NM_002001.3 Latest version!	Homo sapiens Fc fragment of IgE receptor Ia (FCER1A), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FCER1A ( NM_002001.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001992.1 Homo sapiens Fc fragment of IgE receptor Ia (FCER1A), mRNA.

Price & Availability↑

CloneID	OHu23672
Clone ID Related Accession (Same CDS sequence)	NM_002001.3
Accession Version	NM_002001.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 774bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	high affinity immunoglobulin epsilon receptor subunit alpha precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X06948.1. On or before Aug 31, 2013 this sequence version replaced XM_005244956.1, NM_002001.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X06948.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: community standard (PMID:21216468) RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCTCCTG CCATGGAATC CCCTACTCTA CTGTGTGTAG CCTTACTGTT CTTCGCTCCA 
GATGGCGTGT TAGCAGTCCC TCAGAAACCT AAGGTCTCCT TGAACCCTCC ATGGAATAGA 
ATATTTAAAG GAGAGAATGT GACTCTTACA TGTAATGGGA ACAATTTCTT TGAAGTCAGT 
TCCACCAAAT GGTTCCACAA TGGCAGCCTT TCAGAAGAGA CAAATTCAAG TTTGAATATT 
GTGAATGCCA AATTTGAAGA CAGTGGAGAA TACAAATGTC AGCACCAACA AGTTAATGAG 
AGTGAACCTG TGTACCTGGA AGTCTTCAGT GACTGGCTGC TCCTTCAGGC CTCTGCTGAG 
GTGGTGATGG AGGGCCAGCC CCTCTTCCTC AGGTGCCATG GTTGGAGGAA CTGGGATGTG 
TACAAGGTGA TCTATTATAA GGATGGTGAA GCTCTCAAGT ACTGGTATGA GAACCACAAC 
ATCTCCATTA CAAATGCCAC AGTTGAAGAC AGTGGAACCT ACTACTGTAC GGGCAAAGTG 
TGGCAGCTGG ACTATGAGTC TGAGCCCCTC AACATTACTG TAATAAAAGC TCCGCGTGAG 
AAGTACTGGC TACAATTTTT TATCCCATTG TTGGTGGTGA TTCTGTTTGC TGTGGACACA 
GGATTATTTA TCTCAACTCA GCAGCAGGTC ACATTTCTCT TGAAGATTAA GAGAACCAGG 
AAAGGCTTCA GACTTCTGAA CCCACATCCT AAGCCAAACC CCAAAAACAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001992.1
CDS	107..880
Translation	MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN

Target ORF information:

RefSeq Version	NM_002001.3
Organism	Homo sapiens(human)
Definition	Homo sapiens Fc fragment of IgE receptor Ia (FCER1A), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_002001.3

ORF Insert Sequence:

ATGGCTCCTG CCATGGAATC CCCTACTCTA CTGTGTGTAG CCTTACTGTT CTTCGCTCCA 
GATGGCGTGT TAGCAGTCCC TCAGAAACCT AAGGTCTCCT TGAACCCTCC ATGGAATAGA 
ATATTTAAAG GAGAGAATGT GACTCTTACA TGTAATGGGA ACAATTTCTT TGAAGTCAGT 
TCCACCAAAT GGTTCCACAA TGGCAGCCTT TCAGAAGAGA CAAATTCAAG TTTGAATATT 
GTGAATGCCA AATTTGAAGA CAGTGGAGAA TACAAATGTC AGCACCAACA AGTTAATGAG 
AGTGAACCTG TGTACCTGGA AGTCTTCAGT GACTGGCTGC TCCTTCAGGC CTCTGCTGAG 
GTGGTGATGG AGGGCCAGCC CCTCTTCCTC AGGTGCCATG GTTGGAGGAA CTGGGATGTG 
TACAAGGTGA TCTATTATAA GGATGGTGAA GCTCTCAAGT ACTGGTATGA GAACCACAAC 
ATCTCCATTA CAAATGCCAC AGTTGAAGAC AGTGGAACCT ACTACTGTAC GGGCAAAGTG 
TGGCAGCTGG ACTATGAGTC TGAGCCCCTC AACATTACTG TAATAAAAGC TCCGCGTGAG 
AAGTACTGGC TACAATTTTT TATCCCATTG TTGGTGGTGA TTCTGTTTGC TGTGGACACA 
GGATTATTTA TCTCAACTCA GCAGCAGGTC ACATTTCTCT TGAAGATTAA GAGAACCAGG 
AAAGGCTTCA GACTTCTGAA CCCACATCCT AAGCCAAACC CCAAAAACAA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Trapping IgE in a closed conformation by mimicking CD23 binding prevents and disrupts Fc?RI interaction.
Nature communications9(1)7(2018 01)
Jabs F,Plum M,Laursen NS,Jensen RK,M?lgaard B,Miehe M,Mandolesi M,Rauber MM,Pf?tzner W,Jakob T,M?bs C,Andersen GR,Spillner E

Fc?R1? gene polymorphism shows association with high IgE and anti-Fc?R1? in Chronic Rhinosinusitis with Nasal Polyposis.
Journal of cellular biochemistry(2017 Dec)
Dar SA,Rai G,Ansari MA,Akhter N,Gupta N,Sharma S,Haque S,Ramachandran VG,Wahid M,Rudramurthy SM,Chakrabarti A,Das S

Autoreactive T cells in chronic spontaneous urticaria target the IgE Fc receptor I? subunit.
The Journal of allergy and clinical immunology138(3)761-768.e4(2016 Sep)
Auyeung P,Mittag D,Hodgkin PD,Harrison LC

Parameters determining the efficacy of CD32 to inhibit activation of Fc?RI in human basophils.
The Journal of allergy and clinical immunology137(4)1256-1258.e11(2016 Apr)
MacGlashan D Jr,Hamilton RG

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FCER1A cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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