ATOH7 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ATOH7
Entrez Gene ID	220202
Full Name	atonal bHLH transcription factor 7
Synonyms	Math5,NCRNA,PHPVAR,RNANC,bHLHa13
General protein information	Preferred Names atonal bHLH transcription factor 7 Names protein atonal homolog 7 atonal homolog 7 atonal homolog bHLH transcription factor 7 class A basic helix-loop-helix protein 13 helix-loop-helix protein hATH-5
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10q21.3\|10q21.3-q22.1
Summary	This intronless gene encodes a member of the basic helix-loop-helix family of transcription factors, with similarity to Drosophila atonal gene that controls photoreceptor development. Studies in mice suggest that this gene plays a central role in retinal ganglion cell and optic nerve formation. Mutations in this gene are associated with nonsyndromic congenital retinal nonattachment. [provided by RefSeq, Dec 2011].
Disorder MIM:	609875
Disorder Html:	Persistent hyperplastic primary vitreous, autosomal recessive, 221900 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_145178.4	NP_660161.1	protein atonal homolog 7
NM_145178.3	NP_660161.1	protein atonal homolog 7

Pathways from BioSystems

Homologies

Homo sapiens (human)	ATOH7	NP_660161.1
	LOC695268	XP_001083895.1
Bos taurus (cattle)	ATOH7	XP_005226542.1
Mus musculus (house mouse)	Atoh7	NP_058560.1
Rattus norvegicus (Norway rat)	Atoh7	NP_001163953.1
Danio rerio (zebrafish)	atoh7	NP_571707.1
Canis lupus familiaris (dog)	ATOH7	XP_005619000.1
Xenopus tropicalis (tropical clawed frog)	LOC100493495	XP_004915953.1
Pan troglodytes (chimpanzee)	ATOH7	XP_521492.2
Gallus gallus (chicken)	ATOH7	NP_989999.1

Gene Ontology
Bibliography

Related articles in PubMed

The Genetic Causes of Nonsyndromic Congenital Retinal Detachment: A Genetic and Phenotypic Study of Pakistani Families.
Keser V, Khan A, Siddiqui S, Lopez I, Ren H, Qamar R, Nadaf J, Majewski J, Chen R, Koenekoop RK
Investigative ophthalmology & visual science58(2)1028-1036(2017 02)

A Genome-Wide Association Study of Vertical Cup-Disc Ratio in a Latino Population.
Nannini DR, Torres M, Chen YI, Taylor KD, Rotter JI, Varma R, Gao X
Investigative ophthalmology & visual science58(1)87-95(2017 01)

Analysis of Polymorphism rs1900004 in Atonal bHLH Transcription Factor 7 in Saudi Patients with Primary Open Angle Glaucoma.
Kondkar AA, Mousa A, Azad TA, Sultan T, Almobarak FA, Alawad A, Altuwaijri S, Al-Obeidan SA, Abu-Amero KK
Genetic testing and molecular biomarkers20(11)715-718(2016 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We evaluated 21 consanguineous NCRNA pedigrees and identified the causal mutations in known retinal genes in 13 out of our 21 families. We found mutations in ATOH7 in three families.
Title: The Genetic Causes of Nonsyndromic Congenital Retinal Detachment: A Genetic and Phenotypic Study of Pakistani Families.

We discovered a novel SNP, rs56238729 (P = 1.22 x 10-13), in the ATOH7-PBLD region that is significantly associated with VCDR in Latino individuals.
Title: A Genome-Wide Association Study of Vertical Cup-Disc Ratio in a Latino Population.

In conclusion, we have identified a homozygous mutation in the ATOH7 gene in a patient with nonsyndromic congenital retinal nonattachment.
Title: Mutations in ATOH7 gene in patients with nonsyndromic congenital retinal nonattachment and familial exudative vitreoretinopathy.

The genotype and allele frequencies of the polymorphism in ATOH7 did not show any statistically significant association with primary open angle glaucomacompared to controls.
Title: Analysis of Polymorphism rs1900004 in Atonal bHLH Transcription Factor 7 in Saudi Patients with Primary Open Angle Glaucoma.

Familial linkage studies for primary angle-closure glaucoma have been performed and identified ATOH7 causative primary angle-closure glaucoma disease
Title: Advances in glaucoma genetics.

The following ATOH7 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ATOH7 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu20093	NM_145178.4 Latest version!	Homo sapiens atonal bHLH transcription factor 7 (ATOH7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu20093	NM_145178.3	Homo sapiens atonal bHLH transcription factor 7 (ATOH7), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
1 Clone	30% OFF
2-4 Clone	40% OFF
5 or more Clone	50% OFF
All Other ORF Clones
30% OFF

*Business Day

** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ATOH7 ( NM_145178.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_660161.1 Homo sapiens atonal bHLH transcription factor 7 (ATOH7), mRNA.

Price & Availability↑

CloneID	OHu20093
Clone ID Related Accession (Same CDS sequence)	NM_145178.4 , NM_145178.3
Accession Version	NM_145178.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	protein atonal homolog 7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB593109.1, BY797167.2 and H05728.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_145178.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: AB593109.1, AB593108.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000373673.5/ ENSP00000362777.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAAGTCCT GCAAGCCCAG CGGCCCGCCG GCGGGAGCGC GCGTTGCACC CCCGTGCGCG 
GGCGGCACCG AGTGCGCGGG CACGTGCGCC GGGGCCGGGC GGCTGGAGAG CGCGGCGCGC 
AGGCGCCTGG CGGCCAACGC GCGCGAGCGC CGCCGCATGC AGGGGCTCAA CACTGCCTTC 
GACCGCTTAC GCAGGGTGGT TCCCCAGTGG GGCCAGGATA AAAAGCTGTC CAAGTACGAG 
ACCCTGCAGA TGGCCCTGAG CTACATCATG GCTCTGACCC GGATCCTGGC CGAGGCCGAG 
CGATTCGGCT CGGAGCGGGA CTGGGTGGGT CTCCACTGTG AGCACTTCGG CCGCGACCAC 
TACCTCCCGT TCCCGGGCGC GAAGCTGCCG GGCGAGAGCG AGCTGTACAG CCAGAGACTC 
TTCGGCTTCC AGCCCGAGCC CTTCCAGATG GCCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_660161.1
CDS	437..895
Translation	MKSCKPSGPPAGARVAPPCAGGTECAGTCAGAGRLESAARRRLAANARERRRMQGLNTAFDRLRRVVPQWGQDKKLSKYETLQMALSYIMALTRILAEAERFGSERDWVGLHCEHFGRDHYLPFPGAKLPGESELYSQRLFGFQPEPFQMAT

Target ORF information:

RefSeq Version	NM_145178.4
Organism	Homo sapiens(human)
Definition	Homo sapiens atonal bHLH transcription factor 7 (ATOH7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145178.4

ORF Insert Sequence:

ATGAAGTCCT GCAAGCCCAG CGGCCCGCCG GCGGGAGCGC GCGTTGCACC CCCGTGCGCG 
GGCGGCACCG AGTGCGCGGG CACGTGCGCC GGGGCCGGGC GGCTGGAGAG CGCGGCGCGC 
AGGCGCCTGG CGGCCAACGC GCGCGAGCGC CGCCGCATGC AGGGGCTCAA CACTGCCTTC 
GACCGCTTAC GCAGGGTGGT TCCCCAGTGG GGCCAGGATA AAAAGCTGTC CAAGTACGAG 
ACCCTGCAGA TGGCCCTGAG CTACATCATG GCTCTGACCC GGATCCTGGC CGAGGCCGAG 
CGATTCGGCT CGGAGCGGGA CTGGGTGGGT CTCCACTGTG AGCACTTCGG CCGCGACCAC 
TACCTCCCGT TCCCGGGCGC GAAGCTGCCG GGCGAGAGCG AGCTGTACAG CCAGAGACTC 
TTCGGCTTCC AGCCCGAGCC CTTCCAGATG GCCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ATOH7 ( NM_145178.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_660161.1 Homo sapiens atonal bHLH transcription factor 7 (ATOH7), mRNA.

Price & Availability↑

CloneID	OHu20093
Clone ID Related Accession (Same CDS sequence)	NM_145178.4 , NM_145178.3
Accession Version	NM_145178.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	protein atonal homolog 7
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AB593109.1, BY797167.2 and H05728.1. This sequence is a reference standard in the RefSeqGene project. On Dec 16, 2011 this sequence version replaced NM_145178.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. COMPLETENESS: complete on the 3' end.

ATGAAGTCCT GCAAGCCCAG CGGCCCGCCG GCGGGAGCGC GCGTTGCACC CCCGTGCGCG 
GGCGGCACCG AGTGCGCGGG CACGTGCGCC GGGGCCGGGC GGCTGGAGAG CGCGGCGCGC 
AGGCGCCTGG CGGCCAACGC GCGCGAGCGC CGCCGCATGC AGGGGCTCAA CACTGCCTTC 
GACCGCTTAC GCAGGGTGGT TCCCCAGTGG GGCCAGGATA AAAAGCTGTC CAAGTACGAG 
ACCCTGCAGA TGGCCCTGAG CTACATCATG GCTCTGACCC GGATCCTGGC CGAGGCCGAG 
CGATTCGGCT CGGAGCGGGA CTGGGTGGGT CTCCACTGTG AGCACTTCGG CCGCGACCAC 
TACCTCCCGT TCCCGGGCGC GAAGCTGCCG GGCGAGAGCG AGCTGTACAG CCAGAGACTC 
TTCGGCTTCC AGCCCGAGCC CTTCCAGATG GCCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_660161.1
CDS	437..895
Translation	MKSCKPSGPPAGARVAPPCAGGTECAGTCAGAGRLESAARRRLAANARERRRMQGLNTAFDRLRRVVPQWGQDKKLSKYETLQMALSYIMALTRILAEAERFGSERDWVGLHCEHFGRDHYLPFPGAKLPGESELYSQRLFGFQPEPFQMAT

Target ORF information:

RefSeq Version	NM_145178.3
Organism	Homo sapiens(human)
Definition	Homo sapiens atonal bHLH transcription factor 7 (ATOH7), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145178.3

ORF Insert Sequence:

ATGAAGTCCT GCAAGCCCAG CGGCCCGCCG GCGGGAGCGC GCGTTGCACC CCCGTGCGCG 
GGCGGCACCG AGTGCGCGGG CACGTGCGCC GGGGCCGGGC GGCTGGAGAG CGCGGCGCGC 
AGGCGCCTGG CGGCCAACGC GCGCGAGCGC CGCCGCATGC AGGGGCTCAA CACTGCCTTC 
GACCGCTTAC GCAGGGTGGT TCCCCAGTGG GGCCAGGATA AAAAGCTGTC CAAGTACGAG 
ACCCTGCAGA TGGCCCTGAG CTACATCATG GCTCTGACCC GGATCCTGGC CGAGGCCGAG 
CGATTCGGCT CGGAGCGGGA CTGGGTGGGT CTCCACTGTG AGCACTTCGG CCGCGACCAC 
TACCTCCCGT TCCCGGGCGC GAAGCTGCCG GGCGAGAGCG AGCTGTACAG CCAGAGACTC 
TTCGGCTTCC AGCCCGAGCC CTTCCAGATG GCCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The Genetic Causes of Nonsyndromic Congenital Retinal Detachment: A Genetic and Phenotypic Study of Pakistani Families.
Investigative ophthalmology & visual science58(2)1028-1036(2017 02)
Keser V,Khan A,Siddiqui S,Lopez I,Ren H,Qamar R,Nadaf J,Majewski J,Chen R,Koenekoop RK

A Genome-Wide Association Study of Vertical Cup-Disc Ratio in a Latino Population.
Investigative ophthalmology & visual science58(1)87-95(2017 01)
Nannini DR,Torres M,Chen YI,Taylor KD,Rotter JI,Varma R,Gao X

Analysis of Polymorphism rs1900004 in Atonal bHLH Transcription Factor 7 in Saudi Patients with Primary Open Angle Glaucoma.
Genetic testing and molecular biomarkers20(11)715-718(2016 Nov)
Kondkar AA,Mousa A,Azad TA,Sultan T,Almobarak FA,Alawad A,Altuwaijri S,Al-Obeidan SA,Abu-Amero KK

- Most Popular Services
  - 人工遺伝子合成& DNA合成-納期保証
- Services & Products

見積依頼

Eメール

japanmarket@genscript.com

電話

03-6811-6572

FAX

03-6811-6573
050-3174-7589(受注専用)

オンラインフォーム

オンライン注文

ATOH7 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Most Popular Services

Services & Products

見積依頼

Eメール

電話

FAX

オンラインフォーム

サポート

会社情報

サポート

会社情報