FAH cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FAH
Entrez Gene ID	2184
Full Name	fumarylacetoacetate hydrolase
General protein information	Preferred Names fumarylacetoacetate hydrolase Names fumarylacetoacetase FAA beta-diketonase fumarylacetoacetate hydrolase (fumarylacetoacetase)
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 15 Map Location: 15q25.1
Summary	This gene encodes the last enzyme in the tyrosine catabolism pathway. FAH deficiency is associated with Type 1 hereditary tyrosinemia (HT). [provided by RefSeq, Jul 2008].
Disorder MIM:	613871
Disorder Html:	Tyrosinemia, type I, 276700 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_000137.2	NP_000128.1	fumarylacetoacetase
XM_024449872.1	XP_024305640.1	fumarylacetoacetase isoform X1
NM_001374380.1	NP_001361309.1	fumarylacetoacetase
NM_000137.3	NP_000128.1	fumarylacetoacetase
NM_001374377.1	NP_001361306.1	fumarylacetoacetase
NM_000137.4	NP_000128.1	fumarylacetoacetase

Pathways from BioSystems

Homologies

Danio rerio (zebrafish)	fah	NP_955895.1
Drosophila melanogaster (fruit fly)	Faa	NP_524830.2
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP005865	XP_315893.3
Rattus norvegicus (Norway rat)	Fah	NP_058877.1
Caenorhabditis elegans (roundworm)	fah-1	NP_509083.1
Arabidopsis thaliana (thale cress)	AT1G12050	NP_172669.2
Pan troglodytes (chimpanzee)	FAH	XP_001155533.3
Mus musculus (house mouse)	Fah	NP_034306.2
Magnaporthe oryzae (rice blast fungus)	MGG_00317	XP_003718771.1
	FAH	XP_001109382.1
Canis lupus familiaris (dog)	FAH	XP_005618474.1
Neurospora crassa	NCU05537	XP_960499.1
Xenopus tropicalis (tropical clawed frog)	fah	NP_001107523.1
Homo sapiens (human)	FAH	NP_000128.1
Bos taurus (cattle)	FAH	NP_001092382.1
Gallus gallus (chicken)	FAH	NP_001264402.1
Oryza sativa (rice)	Os02g0196800	NP_001046195.1

Gene Ontology
Bibliography

Related articles in PubMed

Molecular Aspects of the FAH Mutations Involved in HT1 Disease.
Morrow G, Angileri F, Tanguay RM
Advances in experimental medicine and biology95925-48(2017)

Silent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma.
Blackburn PR, Hickey RD, Nace RA, Giama NH, Kraft DL, Bordner AJ, Chaiteerakij R, McCormick JB, Radulovic M, Graham RP, Torbenson MS, Tortorelli S, Scott CR, Lindor NM, Milliner DS, Oglesbee D, Al-Qabandi W, Grompe M, Gavrilov DK, El-Youssef M, Clark KJ, Atwal PS, Roberts LR, Klee EW, Ekker SC
Human mutation37(10)1097-105(2016 10)

Direct sequencing of FAH gene in Pakistani tyrosinemia type 1 families reveals a novel mutation.
Ijaz S, Zahoor MY, Imran M, Afzal S, Bhinder MA, Ullah I, Cheema HA, Ramzan K, Shehzad W
Journal of pediatric endocrinology & metabolism : JPEM29(3)327-32(2016 Mar)

Tyrosinemia type 1: a rare and forgotten cause of reversible hypertrophic cardiomyopathy in infancy.
Mohamed S, Kambal MA, Al Jurayyan NA, Al-Nemri A, Babiker A, Hasanato R, Al-Jarallah AS
BMC research notes6362(2013 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results from whole exome sequencing revealed a novel homozygous missense variant in FAH causing tyrosinemia type I . This novel variant involves the catalytic pocket of the enzyme, but does not result in increased succinylacetone or tyrosine.
Title: Silent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma.

FAH gene mutation is associated with tyrosinemia type 1.
Title: Direct sequencing of FAH gene in Pakistani tyrosinemia type 1 families reveals a novel mutation.

Four splicing mutations affecting exonic or intronic nucleotides of the FAH gene were identified in two hereditary tyrosinemia type I patients.
Title: Functional analysis and in vitro correction of splicing FAH mutations causing tyrosinemia type I.

Two siblings have been described with tyrosinemia type 1 complicated by reversible hypertrophic cardiomyopathy in infancy due to a FAH homozygous mutation.
Title: Tyrosinemia type 1: a rare and forgotten cause of reversible hypertrophic cardiomyopathy in infancy.

Compound mutations (R237X and L375P) in the fumarylacetoacetate hydrolase gene causing tyrosinemia type I in a Chinese patient.
Title: Compound mutations (R237X and L375P) in the fumarylacetoacetate hydrolase gene causing tyrosinemia type I in a Chinese patient.

The following FAH gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FAH cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18392	NM_001374380.1 Latest version!	Homo sapiens fumarylacetoacetate hydrolase (FAH), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu18392	NM_001374377.1 Latest version!	Homo sapiens fumarylacetoacetate hydrolase (FAH), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu18392	NM_000137.4 Latest version!	Homo sapiens fumarylacetoacetate hydrolase (FAH), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu18392	XM_024449872.1 Latest version!	Homo sapiens fumarylacetoacetate hydrolase (FAH), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu18392	NM_000137.2	Homo sapiens fumarylacetoacetate hydrolase (FAH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu18392	NM_000137.3	Homo sapiens fumarylacetoacetate hydrolase (FAH), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FAH ( NM_000137.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_000128.1 Homo sapiens fumarylacetoacetate hydrolase (FAH), mRNA.

Price & Availability↑

CloneID	OHu18392
Clone ID Related Accession (Same CDS sequence)	NM_000137.2 , XM_024449872.1 , NM_001374380.1 , NM_000137.3 , NM_001374377.1 , NM_000137.4
Accession Version	NM_000137.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	fumarylacetoacetase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ225295.1, AK313951.1 and BU679766.1. This sequence is a reference standard in the RefSeqGene project. On Apr 22, 2011 this sequence version replaced NM_000137.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163657.406620.1, SRR1163658.228807.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGTCCTTCA TCCCGGTGGC CGAGGATTCC GACTTCCCCA TCCACAACCT GCCCTACGGC 
GTCTTCTCGA CCAGAGGCGA CCCAAGACCG AGGATAGGTG TGGCCATTGG CGACCAGATC 
CTGGACCTCA GCATCATCAA GCACCTCTTT ACTGGTCCTG TCCTCTCCAA ACACCAGGAT 
GTCTTCAATC AGCCTACACT CAACAGCTTC ATGGGCCTGG GTCAGGCTGC CTGGAAGGAG 
GCGAGAGTGT TCTTGCAGAA CTTGCTGTCT GTGAGCCAAG CCAGGCTCAG AGATGACACC 
GAACTTCGGA AGTGTGCATT CATCTCCCAG GCTTCTGCCA CGATGCACCT TCCAGCCACC 
ATAGGAGACT ACACAGACTT CTATTCCTCT CGGCAGCATG CTACCAACGT CGGAATCATG 
TTCAGGGACA AGGAGAATGC GTTGATGCCA AATTGGCTGC ACTTACCAGT GGGCTACCAT 
GGCCGTGCCT CCTCTGTCGT GGTGTCTGGC ACCCCAATCC GAAGGCCCAT GGGACAGATG 
AAACCTGATG ACTCTAAGCC TCCCGTATAT GGTGCCTGCA AGCTCTTGGA CATGGAGCTG 
GAAATGGCTT TTTTTGTAGG CCCTGGAAAC AGATTGGGAG AGCCGATCCC CATTTCCAAG 
GCCCATGAGC ACATTTTTGG AATGGTCCTT ATGAACGACT GGAGTGCACG AGACATTCAG 
AAGTGGGAGT ATGTCCCTCT CGGGCCATTC CTTGGGAAGA GTTTTGGGAC CACTGTCTCT 
CCGTGGGTGG TGCCCATGGA TGCTCTCATG CCCTTTGCTG TGCCCAACCC GAAGCAGGAC 
CCCAGGCCCC TGCCGTATCT GTGCCATGAC GAGCCCTACA CATTTGACAT CAACCTCTCT 
GTTAACCTGA AAGGAGAAGG AATGAGCCAG GCGGCTACCA TATGCAAGTC CAATTTTAAG 
TACATGTACT GGACGATGCT GCAGCAGCTC ACTCACCACT CTGTCAACGG CTGCAACCTG 
CGGCCGGGGG ACCTCCTGGC TTCTGGGACC ATCAGCGGGC CGGAGCCAGA AAACTTCGGC 
TCCATGTTGG AACTGTCGTG GAAGGGAACG AAGCCCATAG ACCTGGGGAA TGGTCAGACC 
AGGAAGTTTC TGCTGGACGG GGATGAAGTC ATCATAACAG GGTACTGCCA GGGGGATGGT 
TACCGCATCG GCTTTGGCCA GTGTGCTGGA AAAGTGCTGC CTGCTCTCCT GCCATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000128.1
CDS	165..1424
Translation	MSFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQDVFNQPTLNSFMGLGQAAWKEARVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHGRASSVVVSGTPIRRPMGQMKPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQKWEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSNFKYMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGYRIGFGQCAGKVLPALLPS

Target ORF information:

RefSeq Version	NM_000137.2
Organism	Homo sapiens(human)
Definition	Homo sapiens fumarylacetoacetate hydrolase (FAH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000137.2

ORF Insert Sequence:

ATGTCCTTCA TCCCGGTGGC CGAGGATTCC GACTTCCCCA TCCACAACCT GCCCTACGGC 
GTCTTCTCGA CCAGAGGCGA CCCAAGACCG AGGATAGGTG TGGCCATTGG CGACCAGATC 
CTGGACCTCA GCATCATCAA GCACCTCTTT ACTGGTCCTG TCCTCTCCAA ACACCAGGAT 
GTCTTCAATC AGCCTACACT CAACAGCTTC ATGGGCCTGG GTCAGGCTGC CTGGAAGGAG 
GCGAGAGTGT TCTTGCAGAA CTTGCTGTCT GTGAGCCAAG CCAGGCTCAG AGATGACACC 
GAACTTCGGA AGTGTGCATT CATCTCCCAG GCTTCTGCCA CGATGCACCT TCCAGCCACC 
ATAGGAGACT ACACAGACTT CTATTCCTCT CGGCAGCATG CTACCAACGT CGGAATCATG 
TTCAGGGACA AGGAGAATGC GTTGATGCCA AATTGGCTGC ACTTACCAGT GGGCTACCAT 
GGCCGTGCCT CCTCTGTCGT GGTGTCTGGC ACCCCAATCC GAAGGCCCAT GGGACAGATG 
AAACCTGATG ACTCTAAGCC TCCCGTATAT GGTGCCTGCA AGCTCTTGGA CATGGAGCTG 
GAAATGGCTT TTTTTGTAGG CCCTGGAAAC AGATTGGGAG AGCCGATCCC CATTTCCAAG 
GCCCATGAGC ACATTTTTGG AATGGTCCTT ATGAACGACT GGAGTGCACG AGACATTCAG 
AAGTGGGAGT ATGTCCCTCT CGGGCCATTC CTTGGGAAGA GTTTTGGGAC CACTGTCTCT 
CCGTGGGTGG TGCCCATGGA TGCTCTCATG CCCTTTGCTG TGCCCAACCC GAAGCAGGAC 
CCCAGGCCCC TGCCGTATCT GTGCCATGAC GAGCCCTACA CATTTGACAT CAACCTCTCT 
GTTAACCTGA AAGGAGAAGG AATGAGCCAG GCGGCTACCA TATGCAAGTC CAATTTTAAG 
TACATGTACT GGACGATGCT GCAGCAGCTC ACTCACCACT CTGTCAACGG CTGCAACCTG 
CGGCCGGGGG ACCTCCTGGC TTCTGGGACC ATCAGCGGGC CGGAGCCAGA AAACTTCGGC 
TCCATGTTGG AACTGTCGTG GAAGGGAACG AAGCCCATAG ACCTGGGGAA TGGTCAGACC 
AGGAAGTTTC TGCTGGACGG GGATGAAGTC ATCATAACAG GGTACTGCCA GGGGGATGGT 
TACCGCATCG GCTTTGGCCA GTGTGCTGGA AAAGTGCTGC CTGCTCTCCT GCCATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAH ( NM_001374380.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001361309.1 Homo sapiens fumarylacetoacetate hydrolase (FAH), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu18392
Clone ID Related Accession (Same CDS sequence)	NM_000137.2 , XM_024449872.1 , NM_001374380.1 , NM_000137.3 , NM_001374377.1 , NM_000137.4
Accession Version	NM_001374380.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-27
Organism	Homo sapiens(human)
Product	fumarylacetoacetase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087761.6. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR3476690.990723.1, SRR1803616.324921.1 [ECO:0000332] ##Evidence-Data-END##

ATGTCCTTCA TCCCGGTGGC CGAGGATTCC GACTTCCCCA TCCACAACCT GCCCTACGGC 
GTCTTCTCGA CCAGAGGCGA CCCAAGACCG AGGATAGGTG TGGCCATTGG CGACCAGATC 
CTGGACCTCA GCATCATCAA GCACCTCTTT ACTGGTCCTG TCCTCTCCAA ACACCAGGAT 
GTCTTCAATC AGCCTACACT CAACAGCTTC ATGGGCCTGG GTCAGGCTGC CTGGAAGGAG 
GCGAGAGTGT TCTTGCAGAA CTTGCTGTCT GTGAGCCAAG CCAGGCTCAG AGATGACACC 
GAACTTCGGA AGTGTGCATT CATCTCCCAG GCTTCTGCCA CGATGCACCT TCCAGCCACC 
ATAGGAGACT ACACAGACTT CTATTCCTCT CGGCAGCATG CTACCAACGT CGGAATCATG 
TTCAGGGACA AGGAGAATGC GTTGATGCCA AATTGGCTGC ACTTACCAGT GGGCTACCAT 
GGCCGTGCCT CCTCTGTCGT GGTGTCTGGC ACCCCAATCC GAAGGCCCAT GGGACAGATG 
AAACCTGATG ACTCTAAGCC TCCCGTATAT GGTGCCTGCA AGCTCTTGGA CATGGAGCTG 
GAAATGGCTT TTTTTGTAGG CCCTGGAAAC AGATTGGGAG AGCCGATCCC CATTTCCAAG 
GCCCATGAGC ACATTTTTGG AATGGTCCTT ATGAACGACT GGAGTGCACG AGACATTCAG 
AAGTGGGAGT ATGTCCCTCT CGGGCCATTC CTTGGGAAGA GTTTTGGGAC CACTGTCTCT 
CCGTGGGTGG TGCCCATGGA TGCTCTCATG CCCTTTGCTG TGCCCAACCC GAAGCAGGAC 
CCCAGGCCCC TGCCGTATCT GTGCCATGAC GAGCCCTACA CATTTGACAT CAACCTCTCT 
GTTAACCTGA AAGGAGAAGG AATGAGCCAG GCGGCTACCA TATGCAAGTC CAATTTTAAG 
TACATGTACT GGACGATGCT GCAGCAGCTC ACTCACCACT CTGTCAACGG CTGCAACCTG 
CGGCCGGGGG ACCTCCTGGC TTCTGGGACC ATCAGCGGGC CGGAGCCAGA AAACTTCGGC 
TCCATGTTGG AACTGTCGTG GAAGGGAACG AAGCCCATAG ACCTGGGGAA TGGTCAGACC 
AGGAAGTTTC TGCTGGACGG GGATGAAGTC ATCATAACAG GGTACTGCCA GGGGGATGGT 
TACCGCATCG GCTTTGGCCA GTGTGCTGGA AAAGTGCTGC CTGCTCTCCT GCCATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001361309.1
CDS	83..1342
Translation	MSFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQDVFNQPTLNSFMGLGQAAWKEARVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHGRASSVVVSGTPIRRPMGQMKPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQKWEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSNFKYMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGYRIGFGQCAGKVLPALLPS

Target ORF information:

RefSeq Version	NM_001374380.1
Organism	Homo sapiens(human)
Definition	Homo sapiens fumarylacetoacetate hydrolase (FAH), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001374380.1

ORF Insert Sequence:

ATGTCCTTCA TCCCGGTGGC CGAGGATTCC GACTTCCCCA TCCACAACCT GCCCTACGGC 
GTCTTCTCGA CCAGAGGCGA CCCAAGACCG AGGATAGGTG TGGCCATTGG CGACCAGATC 
CTGGACCTCA GCATCATCAA GCACCTCTTT ACTGGTCCTG TCCTCTCCAA ACACCAGGAT 
GTCTTCAATC AGCCTACACT CAACAGCTTC ATGGGCCTGG GTCAGGCTGC CTGGAAGGAG 
GCGAGAGTGT TCTTGCAGAA CTTGCTGTCT GTGAGCCAAG CCAGGCTCAG AGATGACACC 
GAACTTCGGA AGTGTGCATT CATCTCCCAG GCTTCTGCCA CGATGCACCT TCCAGCCACC 
ATAGGAGACT ACACAGACTT CTATTCCTCT CGGCAGCATG CTACCAACGT CGGAATCATG 
TTCAGGGACA AGGAGAATGC GTTGATGCCA AATTGGCTGC ACTTACCAGT GGGCTACCAT 
GGCCGTGCCT CCTCTGTCGT GGTGTCTGGC ACCCCAATCC GAAGGCCCAT GGGACAGATG 
AAACCTGATG ACTCTAAGCC TCCCGTATAT GGTGCCTGCA AGCTCTTGGA CATGGAGCTG 
GAAATGGCTT TTTTTGTAGG CCCTGGAAAC AGATTGGGAG AGCCGATCCC CATTTCCAAG 
GCCCATGAGC ACATTTTTGG AATGGTCCTT ATGAACGACT GGAGTGCACG AGACATTCAG 
AAGTGGGAGT ATGTCCCTCT CGGGCCATTC CTTGGGAAGA GTTTTGGGAC CACTGTCTCT 
CCGTGGGTGG TGCCCATGGA TGCTCTCATG CCCTTTGCTG TGCCCAACCC GAAGCAGGAC 
CCCAGGCCCC TGCCGTATCT GTGCCATGAC GAGCCCTACA CATTTGACAT CAACCTCTCT 
GTTAACCTGA AAGGAGAAGG AATGAGCCAG GCGGCTACCA TATGCAAGTC CAATTTTAAG 
TACATGTACT GGACGATGCT GCAGCAGCTC ACTCACCACT CTGTCAACGG CTGCAACCTG 
CGGCCGGGGG ACCTCCTGGC TTCTGGGACC ATCAGCGGGC CGGAGCCAGA AAACTTCGGC 
TCCATGTTGG AACTGTCGTG GAAGGGAACG AAGCCCATAG ACCTGGGGAA TGGTCAGACC 
AGGAAGTTTC TGCTGGACGG GGATGAAGTC ATCATAACAG GGTACTGCCA GGGGGATGGT 
TACCGCATCG GCTTTGGCCA GTGTGCTGGA AAAGTGCTGC CTGCTCTCCT GCCATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAH ( NM_000137.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000128.1 Homo sapiens fumarylacetoacetate hydrolase (FAH), mRNA.

Price & Availability↑

CloneID	OHu18392
Clone ID Related Accession (Same CDS sequence)	NM_000137.2 , XM_024449872.1 , NM_001374380.1 , NM_000137.3 , NM_001374377.1 , NM_000137.4
Accession Version	NM_000137.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-01
Organism	Homo sapiens(human)
Product	fumarylacetoacetase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313951.1, BU679766.1 and AC087761.6. On Jun 2, 2019 this sequence version replaced NM_000137.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M55150.1, SRR5189667.352845.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGTCCTTCA TCCCGGTGGC CGAGGATTCC GACTTCCCCA TCCACAACCT GCCCTACGGC 
GTCTTCTCGA CCAGAGGCGA CCCAAGACCG AGGATAGGTG TGGCCATTGG CGACCAGATC 
CTGGACCTCA GCATCATCAA GCACCTCTTT ACTGGTCCTG TCCTCTCCAA ACACCAGGAT 
GTCTTCAATC AGCCTACACT CAACAGCTTC ATGGGCCTGG GTCAGGCTGC CTGGAAGGAG 
GCGAGAGTGT TCTTGCAGAA CTTGCTGTCT GTGAGCCAAG CCAGGCTCAG AGATGACACC 
GAACTTCGGA AGTGTGCATT CATCTCCCAG GCTTCTGCCA CGATGCACCT TCCAGCCACC 
ATAGGAGACT ACACAGACTT CTATTCCTCT CGGCAGCATG CTACCAACGT CGGAATCATG 
TTCAGGGACA AGGAGAATGC GTTGATGCCA AATTGGCTGC ACTTACCAGT GGGCTACCAT 
GGCCGTGCCT CCTCTGTCGT GGTGTCTGGC ACCCCAATCC GAAGGCCCAT GGGACAGATG 
AAACCTGATG ACTCTAAGCC TCCCGTATAT GGTGCCTGCA AGCTCTTGGA CATGGAGCTG 
GAAATGGCTT TTTTTGTAGG CCCTGGAAAC AGATTGGGAG AGCCGATCCC CATTTCCAAG 
GCCCATGAGC ACATTTTTGG AATGGTCCTT ATGAACGACT GGAGTGCACG AGACATTCAG 
AAGTGGGAGT ATGTCCCTCT CGGGCCATTC CTTGGGAAGA GTTTTGGGAC CACTGTCTCT 
CCGTGGGTGG TGCCCATGGA TGCTCTCATG CCCTTTGCTG TGCCCAACCC GAAGCAGGAC 
CCCAGGCCCC TGCCGTATCT GTGCCATGAC GAGCCCTACA CATTTGACAT CAACCTCTCT 
GTTAACCTGA AAGGAGAAGG AATGAGCCAG GCGGCTACCA TATGCAAGTC CAATTTTAAG 
TACATGTACT GGACGATGCT GCAGCAGCTC ACTCACCACT CTGTCAACGG CTGCAACCTG 
CGGCCGGGGG ACCTCCTGGC TTCTGGGACC ATCAGCGGGC CGGAGCCAGA AAACTTCGGC 
TCCATGTTGG AACTGTCGTG GAAGGGAACG AAGCCCATAG ACCTGGGGAA TGGTCAGACC 
AGGAAGTTTC TGCTGGACGG GGATGAAGTC ATCATAACAG GGTACTGCCA GGGGGATGGT 
TACCGCATCG GCTTTGGCCA GTGTGCTGGA AAAGTGCTGC CTGCTCTCCT GCCATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000128.1
CDS	57..1316
Translation	MSFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQDVFNQPTLNSFMGLGQAAWKEARVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHGRASSVVVSGTPIRRPMGQMKPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQKWEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSNFKYMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGYRIGFGQCAGKVLPALLPS

Target ORF information:

RefSeq Version	NM_000137.3
Organism	Homo sapiens(human)
Definition	Homo sapiens fumarylacetoacetate hydrolase (FAH), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000137.3

ORF Insert Sequence:

ATGTCCTTCA TCCCGGTGGC CGAGGATTCC GACTTCCCCA TCCACAACCT GCCCTACGGC 
GTCTTCTCGA CCAGAGGCGA CCCAAGACCG AGGATAGGTG TGGCCATTGG CGACCAGATC 
CTGGACCTCA GCATCATCAA GCACCTCTTT ACTGGTCCTG TCCTCTCCAA ACACCAGGAT 
GTCTTCAATC AGCCTACACT CAACAGCTTC ATGGGCCTGG GTCAGGCTGC CTGGAAGGAG 
GCGAGAGTGT TCTTGCAGAA CTTGCTGTCT GTGAGCCAAG CCAGGCTCAG AGATGACACC 
GAACTTCGGA AGTGTGCATT CATCTCCCAG GCTTCTGCCA CGATGCACCT TCCAGCCACC 
ATAGGAGACT ACACAGACTT CTATTCCTCT CGGCAGCATG CTACCAACGT CGGAATCATG 
TTCAGGGACA AGGAGAATGC GTTGATGCCA AATTGGCTGC ACTTACCAGT GGGCTACCAT 
GGCCGTGCCT CCTCTGTCGT GGTGTCTGGC ACCCCAATCC GAAGGCCCAT GGGACAGATG 
AAACCTGATG ACTCTAAGCC TCCCGTATAT GGTGCCTGCA AGCTCTTGGA CATGGAGCTG 
GAAATGGCTT TTTTTGTAGG CCCTGGAAAC AGATTGGGAG AGCCGATCCC CATTTCCAAG 
GCCCATGAGC ACATTTTTGG AATGGTCCTT ATGAACGACT GGAGTGCACG AGACATTCAG 
AAGTGGGAGT ATGTCCCTCT CGGGCCATTC CTTGGGAAGA GTTTTGGGAC CACTGTCTCT 
CCGTGGGTGG TGCCCATGGA TGCTCTCATG CCCTTTGCTG TGCCCAACCC GAAGCAGGAC 
CCCAGGCCCC TGCCGTATCT GTGCCATGAC GAGCCCTACA CATTTGACAT CAACCTCTCT 
GTTAACCTGA AAGGAGAAGG AATGAGCCAG GCGGCTACCA TATGCAAGTC CAATTTTAAG 
TACATGTACT GGACGATGCT GCAGCAGCTC ACTCACCACT CTGTCAACGG CTGCAACCTG 
CGGCCGGGGG ACCTCCTGGC TTCTGGGACC ATCAGCGGGC CGGAGCCAGA AAACTTCGGC 
TCCATGTTGG AACTGTCGTG GAAGGGAACG AAGCCCATAG ACCTGGGGAA TGGTCAGACC 
AGGAAGTTTC TGCTGGACGG GGATGAAGTC ATCATAACAG GGTACTGCCA GGGGGATGGT 
TACCGCATCG GCTTTGGCCA GTGTGCTGGA AAAGTGCTGC CTGCTCTCCT GCCATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAH ( NM_001374377.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001361306.1 Homo sapiens fumarylacetoacetate hydrolase (FAH), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18392
Clone ID Related Accession (Same CDS sequence)	NM_000137.2 , XM_024449872.1 , NM_001374380.1 , NM_000137.3 , NM_001374377.1 , NM_000137.4
Accession Version	NM_001374377.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-02
Organism	Homo sapiens(human)
Product	fumarylacetoacetase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC087761.6. On Sep 24, 2019 this sequence version replaced XM_024449872.1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.1248515.1, SRR7346977.697966.1 [ECO:0000332] ##Evidence-Data-END##

ATGTCCTTCA TCCCGGTGGC CGAGGATTCC GACTTCCCCA TCCACAACCT GCCCTACGGC 
GTCTTCTCGA CCAGAGGCGA CCCAAGACCG AGGATAGGTG TGGCCATTGG CGACCAGATC 
CTGGACCTCA GCATCATCAA GCACCTCTTT ACTGGTCCTG TCCTCTCCAA ACACCAGGAT 
GTCTTCAATC AGCCTACACT CAACAGCTTC ATGGGCCTGG GTCAGGCTGC CTGGAAGGAG 
GCGAGAGTGT TCTTGCAGAA CTTGCTGTCT GTGAGCCAAG CCAGGCTCAG AGATGACACC 
GAACTTCGGA AGTGTGCATT CATCTCCCAG GCTTCTGCCA CGATGCACCT TCCAGCCACC 
ATAGGAGACT ACACAGACTT CTATTCCTCT CGGCAGCATG CTACCAACGT CGGAATCATG 
TTCAGGGACA AGGAGAATGC GTTGATGCCA AATTGGCTGC ACTTACCAGT GGGCTACCAT 
GGCCGTGCCT CCTCTGTCGT GGTGTCTGGC ACCCCAATCC GAAGGCCCAT GGGACAGATG 
AAACCTGATG ACTCTAAGCC TCCCGTATAT GGTGCCTGCA AGCTCTTGGA CATGGAGCTG 
GAAATGGCTT TTTTTGTAGG CCCTGGAAAC AGATTGGGAG AGCCGATCCC CATTTCCAAG 
GCCCATGAGC ACATTTTTGG AATGGTCCTT ATGAACGACT GGAGTGCACG AGACATTCAG 
AAGTGGGAGT ATGTCCCTCT CGGGCCATTC CTTGGGAAGA GTTTTGGGAC CACTGTCTCT 
CCGTGGGTGG TGCCCATGGA TGCTCTCATG CCCTTTGCTG TGCCCAACCC GAAGCAGGAC 
CCCAGGCCCC TGCCGTATCT GTGCCATGAC GAGCCCTACA CATTTGACAT CAACCTCTCT 
GTTAACCTGA AAGGAGAAGG AATGAGCCAG GCGGCTACCA TATGCAAGTC CAATTTTAAG 
TACATGTACT GGACGATGCT GCAGCAGCTC ACTCACCACT CTGTCAACGG CTGCAACCTG 
CGGCCGGGGG ACCTCCTGGC TTCTGGGACC ATCAGCGGGC CGGAGCCAGA AAACTTCGGC 
TCCATGTTGG AACTGTCGTG GAAGGGAACG AAGCCCATAG ACCTGGGGAA TGGTCAGACC 
AGGAAGTTTC TGCTGGACGG GGATGAAGTC ATCATAACAG GGTACTGCCA GGGGGATGGT 
TACCGCATCG GCTTTGGCCA GTGTGCTGGA AAAGTGCTGC CTGCTCTCCT GCCATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001361306.1
CDS	147..1406
Translation	MSFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQDVFNQPTLNSFMGLGQAAWKEARVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHGRASSVVVSGTPIRRPMGQMKPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQKWEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSNFKYMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGYRIGFGQCAGKVLPALLPS

Target ORF information:

RefSeq Version	NM_001374377.1
Organism	Homo sapiens(human)
Definition	Homo sapiens fumarylacetoacetate hydrolase (FAH), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001374377.1

ORF Insert Sequence:

ATGTCCTTCA TCCCGGTGGC CGAGGATTCC GACTTCCCCA TCCACAACCT GCCCTACGGC 
GTCTTCTCGA CCAGAGGCGA CCCAAGACCG AGGATAGGTG TGGCCATTGG CGACCAGATC 
CTGGACCTCA GCATCATCAA GCACCTCTTT ACTGGTCCTG TCCTCTCCAA ACACCAGGAT 
GTCTTCAATC AGCCTACACT CAACAGCTTC ATGGGCCTGG GTCAGGCTGC CTGGAAGGAG 
GCGAGAGTGT TCTTGCAGAA CTTGCTGTCT GTGAGCCAAG CCAGGCTCAG AGATGACACC 
GAACTTCGGA AGTGTGCATT CATCTCCCAG GCTTCTGCCA CGATGCACCT TCCAGCCACC 
ATAGGAGACT ACACAGACTT CTATTCCTCT CGGCAGCATG CTACCAACGT CGGAATCATG 
TTCAGGGACA AGGAGAATGC GTTGATGCCA AATTGGCTGC ACTTACCAGT GGGCTACCAT 
GGCCGTGCCT CCTCTGTCGT GGTGTCTGGC ACCCCAATCC GAAGGCCCAT GGGACAGATG 
AAACCTGATG ACTCTAAGCC TCCCGTATAT GGTGCCTGCA AGCTCTTGGA CATGGAGCTG 
GAAATGGCTT TTTTTGTAGG CCCTGGAAAC AGATTGGGAG AGCCGATCCC CATTTCCAAG 
GCCCATGAGC ACATTTTTGG AATGGTCCTT ATGAACGACT GGAGTGCACG AGACATTCAG 
AAGTGGGAGT ATGTCCCTCT CGGGCCATTC CTTGGGAAGA GTTTTGGGAC CACTGTCTCT 
CCGTGGGTGG TGCCCATGGA TGCTCTCATG CCCTTTGCTG TGCCCAACCC GAAGCAGGAC 
CCCAGGCCCC TGCCGTATCT GTGCCATGAC GAGCCCTACA CATTTGACAT CAACCTCTCT 
GTTAACCTGA AAGGAGAAGG AATGAGCCAG GCGGCTACCA TATGCAAGTC CAATTTTAAG 
TACATGTACT GGACGATGCT GCAGCAGCTC ACTCACCACT CTGTCAACGG CTGCAACCTG 
CGGCCGGGGG ACCTCCTGGC TTCTGGGACC ATCAGCGGGC CGGAGCCAGA AAACTTCGGC 
TCCATGTTGG AACTGTCGTG GAAGGGAACG AAGCCCATAG ACCTGGGGAA TGGTCAGACC 
AGGAAGTTTC TGCTGGACGG GGATGAAGTC ATCATAACAG GGTACTGCCA GGGGGATGGT 
TACCGCATCG GCTTTGGCCA GTGTGCTGGA AAAGTGCTGC CTGCTCTCCT GCCATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAH ( NM_000137.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000128.1 Homo sapiens fumarylacetoacetate hydrolase (FAH), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18392
Clone ID Related Accession (Same CDS sequence)	NM_000137.2 , XM_024449872.1 , NM_001374380.1 , NM_000137.3 , NM_001374377.1 , NM_000137.4
Accession Version	NM_000137.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-19
Organism	Homo sapiens(human)
Product	fumarylacetoacetase
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK313951.1 and BU679766.1. This sequence is a reference standard in the RefSeqGene project. On Nov 26, 2019 this sequence version replaced NM_000137.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M55150.1, GQ891433.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END##

ATGTCCTTCA TCCCGGTGGC CGAGGATTCC GACTTCCCCA TCCACAACCT GCCCTACGGC 
GTCTTCTCGA CCAGAGGCGA CCCAAGACCG AGGATAGGTG TGGCCATTGG CGACCAGATC 
CTGGACCTCA GCATCATCAA GCACCTCTTT ACTGGTCCTG TCCTCTCCAA ACACCAGGAT 
GTCTTCAATC AGCCTACACT CAACAGCTTC ATGGGCCTGG GTCAGGCTGC CTGGAAGGAG 
GCGAGAGTGT TCTTGCAGAA CTTGCTGTCT GTGAGCCAAG CCAGGCTCAG AGATGACACC 
GAACTTCGGA AGTGTGCATT CATCTCCCAG GCTTCTGCCA CGATGCACCT TCCAGCCACC 
ATAGGAGACT ACACAGACTT CTATTCCTCT CGGCAGCATG CTACCAACGT CGGAATCATG 
TTCAGGGACA AGGAGAATGC GTTGATGCCA AATTGGCTGC ACTTACCAGT GGGCTACCAT 
GGCCGTGCCT CCTCTGTCGT GGTGTCTGGC ACCCCAATCC GAAGGCCCAT GGGACAGATG 
AAACCTGATG ACTCTAAGCC TCCCGTATAT GGTGCCTGCA AGCTCTTGGA CATGGAGCTG 
GAAATGGCTT TTTTTGTAGG CCCTGGAAAC AGATTGGGAG AGCCGATCCC CATTTCCAAG 
GCCCATGAGC ACATTTTTGG AATGGTCCTT ATGAACGACT GGAGTGCACG AGACATTCAG 
AAGTGGGAGT ATGTCCCTCT CGGGCCATTC CTTGGGAAGA GTTTTGGGAC CACTGTCTCT 
CCGTGGGTGG TGCCCATGGA TGCTCTCATG CCCTTTGCTG TGCCCAACCC GAAGCAGGAC 
CCCAGGCCCC TGCCGTATCT GTGCCATGAC GAGCCCTACA CATTTGACAT CAACCTCTCT 
GTTAACCTGA AAGGAGAAGG AATGAGCCAG GCGGCTACCA TATGCAAGTC CAATTTTAAG 
TACATGTACT GGACGATGCT GCAGCAGCTC ACTCACCACT CTGTCAACGG CTGCAACCTG 
CGGCCGGGGG ACCTCCTGGC TTCTGGGACC ATCAGCGGGC CGGAGCCAGA AAACTTCGGC 
TCCATGTTGG AACTGTCGTG GAAGGGAACG AAGCCCATAG ACCTGGGGAA TGGTCAGACC 
AGGAAGTTTC TGCTGGACGG GGATGAAGTC ATCATAACAG GGTACTGCCA GGGGGATGGT 
TACCGCATCG GCTTTGGCCA GTGTGCTGGA AAAGTGCTGC CTGCTCTCCT GCCATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000128.1
CDS	57..1316
Translation	MSFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQDVFNQPTLNSFMGLGQAAWKEARVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHGRASSVVVSGTPIRRPMGQMKPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQKWEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSNFKYMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGYRIGFGQCAGKVLPALLPS

Target ORF information:

RefSeq Version	NM_000137.4
Organism	Homo sapiens(human)
Definition	Homo sapiens fumarylacetoacetate hydrolase (FAH), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000137.4

ORF Insert Sequence:

ATGTCCTTCA TCCCGGTGGC CGAGGATTCC GACTTCCCCA TCCACAACCT GCCCTACGGC 
GTCTTCTCGA CCAGAGGCGA CCCAAGACCG AGGATAGGTG TGGCCATTGG CGACCAGATC 
CTGGACCTCA GCATCATCAA GCACCTCTTT ACTGGTCCTG TCCTCTCCAA ACACCAGGAT 
GTCTTCAATC AGCCTACACT CAACAGCTTC ATGGGCCTGG GTCAGGCTGC CTGGAAGGAG 
GCGAGAGTGT TCTTGCAGAA CTTGCTGTCT GTGAGCCAAG CCAGGCTCAG AGATGACACC 
GAACTTCGGA AGTGTGCATT CATCTCCCAG GCTTCTGCCA CGATGCACCT TCCAGCCACC 
ATAGGAGACT ACACAGACTT CTATTCCTCT CGGCAGCATG CTACCAACGT CGGAATCATG 
TTCAGGGACA AGGAGAATGC GTTGATGCCA AATTGGCTGC ACTTACCAGT GGGCTACCAT 
GGCCGTGCCT CCTCTGTCGT GGTGTCTGGC ACCCCAATCC GAAGGCCCAT GGGACAGATG 
AAACCTGATG ACTCTAAGCC TCCCGTATAT GGTGCCTGCA AGCTCTTGGA CATGGAGCTG 
GAAATGGCTT TTTTTGTAGG CCCTGGAAAC AGATTGGGAG AGCCGATCCC CATTTCCAAG 
GCCCATGAGC ACATTTTTGG AATGGTCCTT ATGAACGACT GGAGTGCACG AGACATTCAG 
AAGTGGGAGT ATGTCCCTCT CGGGCCATTC CTTGGGAAGA GTTTTGGGAC CACTGTCTCT 
CCGTGGGTGG TGCCCATGGA TGCTCTCATG CCCTTTGCTG TGCCCAACCC GAAGCAGGAC 
CCCAGGCCCC TGCCGTATCT GTGCCATGAC GAGCCCTACA CATTTGACAT CAACCTCTCT 
GTTAACCTGA AAGGAGAAGG AATGAGCCAG GCGGCTACCA TATGCAAGTC CAATTTTAAG 
TACATGTACT GGACGATGCT GCAGCAGCTC ACTCACCACT CTGTCAACGG CTGCAACCTG 
CGGCCGGGGG ACCTCCTGGC TTCTGGGACC ATCAGCGGGC CGGAGCCAGA AAACTTCGGC 
TCCATGTTGG AACTGTCGTG GAAGGGAACG AAGCCCATAG ACCTGGGGAA TGGTCAGACC 
AGGAAGTTTC TGCTGGACGG GGATGAAGTC ATCATAACAG GGTACTGCCA GGGGGATGGT 
TACCGCATCG GCTTTGGCCA GTGTGCTGGA AAAGTGCTGC CTGCTCTCCT GCCATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FAH ( XM_024449872.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024305640.1 Homo sapiens fumarylacetoacetate hydrolase (FAH), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu18392
Clone ID Related Accession (Same CDS sequence)	NM_000137.2 , XM_024449872.1 , NM_001374380.1 , NM_000137.3 , NM_001374377.1 , NM_000137.4
Accession Version	XM_024449872.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1260bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-12
Organism	Homo sapiens(human)
Product	fumarylacetoacetase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000015.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20190607 Annotation Version :: 109.20190607 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.2 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA Annotation Freeze :: 20190607 ##Genome-Annotation-Data-END##

ATGTCCTTCA TCCCGGTGGC CGAGGATTCC GACTTCCCCA TCCACAACCT GCCCTACGGC 
GTCTTCTCGA CCAGAGGCGA CCCAAGACCG AGGATAGGTG TGGCCATTGG CGACCAGATC 
CTGGACCTCA GCATCATCAA GCACCTCTTT ACTGGTCCTG TCCTCTCCAA ACACCAGGAT 
GTCTTCAATC AGCCTACACT CAACAGCTTC ATGGGCCTGG GTCAGGCTGC CTGGAAGGAG 
GCGAGAGTGT TCTTGCAGAA CTTGCTGTCT GTGAGCCAAG CCAGGCTCAG AGATGACACC 
GAACTTCGGA AGTGTGCATT CATCTCCCAG GCTTCTGCCA CGATGCACCT TCCAGCCACC 
ATAGGAGACT ACACAGACTT CTATTCCTCT CGGCAGCATG CTACCAACGT CGGAATCATG 
TTCAGGGACA AGGAGAATGC GTTGATGCCA AATTGGCTGC ACTTACCAGT GGGCTACCAT 
GGCCGTGCCT CCTCTGTCGT GGTGTCTGGC ACCCCAATCC GAAGGCCCAT GGGACAGATG 
AAACCTGATG ACTCTAAGCC TCCCGTATAT GGTGCCTGCA AGCTCTTGGA CATGGAGCTG 
GAAATGGCTT TTTTTGTAGG CCCTGGAAAC AGATTGGGAG AGCCGATCCC CATTTCCAAG 
GCCCATGAGC ACATTTTTGG AATGGTCCTT ATGAACGACT GGAGTGCACG AGACATTCAG 
AAGTGGGAGT ATGTCCCTCT CGGGCCATTC CTTGGGAAGA GTTTTGGGAC CACTGTCTCT 
CCGTGGGTGG TGCCCATGGA TGCTCTCATG CCCTTTGCTG TGCCCAACCC GAAGCAGGAC 
CCCAGGCCCC TGCCGTATCT GTGCCATGAC GAGCCCTACA CATTTGACAT CAACCTCTCT 
GTTAACCTGA AAGGAGAAGG AATGAGCCAG GCGGCTACCA TATGCAAGTC CAATTTTAAG 
TACATGTACT GGACGATGCT GCAGCAGCTC ACTCACCACT CTGTCAACGG CTGCAACCTG 
CGGCCGGGGG ACCTCCTGGC TTCTGGGACC ATCAGCGGGC CGGAGCCAGA AAACTTCGGC 
TCCATGTTGG AACTGTCGTG GAAGGGAACG AAGCCCATAG ACCTGGGGAA TGGTCAGACC 
AGGAAGTTTC TGCTGGACGG GGATGAAGTC ATCATAACAG GGTACTGCCA GGGGGATGGT 
TACCGCATCG GCTTTGGCCA GTGTGCTGGA AAAGTGCTGC CTGCTCTCCT GCCATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024305640.1
CDS	113..1372
Translation	MSFIPVAEDSDFPIHNLPYGVFSTRGDPRPRIGVAIGDQILDLSIIKHLFTGPVLSKHQDVFNQPTLNSFMGLGQAAWKEARVFLQNLLSVSQARLRDDTELRKCAFISQASATMHLPATIGDYTDFYSSRQHATNVGIMFRDKENALMPNWLHLPVGYHGRASSVVVSGTPIRRPMGQMKPDDSKPPVYGACKLLDMELEMAFFVGPGNRLGEPIPISKAHEHIFGMVLMNDWSARDIQKWEYVPLGPFLGKSFGTTVSPWVVPMDALMPFAVPNPKQDPRPLPYLCHDEPYTFDINLSVNLKGEGMSQAATICKSNFKYMYWTMLQQLTHHSVNGCNLRPGDLLASGTISGPEPENFGSMLELSWKGTKPIDLGNGQTRKFLLDGDEVIITGYCQGDGYRIGFGQCAGKVLPALLPS

Target ORF information:

RefSeq Version	XM_024449872.1
Organism	Homo sapiens(human)
Definition	Homo sapiens fumarylacetoacetate hydrolase (FAH), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024449872.1

ORF Insert Sequence:

ATGTCCTTCA TCCCGGTGGC CGAGGATTCC GACTTCCCCA TCCACAACCT GCCCTACGGC 
GTCTTCTCGA CCAGAGGCGA CCCAAGACCG AGGATAGGTG TGGCCATTGG CGACCAGATC 
CTGGACCTCA GCATCATCAA GCACCTCTTT ACTGGTCCTG TCCTCTCCAA ACACCAGGAT 
GTCTTCAATC AGCCTACACT CAACAGCTTC ATGGGCCTGG GTCAGGCTGC CTGGAAGGAG 
GCGAGAGTGT TCTTGCAGAA CTTGCTGTCT GTGAGCCAAG CCAGGCTCAG AGATGACACC 
GAACTTCGGA AGTGTGCATT CATCTCCCAG GCTTCTGCCA CGATGCACCT TCCAGCCACC 
ATAGGAGACT ACACAGACTT CTATTCCTCT CGGCAGCATG CTACCAACGT CGGAATCATG 
TTCAGGGACA AGGAGAATGC GTTGATGCCA AATTGGCTGC ACTTACCAGT GGGCTACCAT 
GGCCGTGCCT CCTCTGTCGT GGTGTCTGGC ACCCCAATCC GAAGGCCCAT GGGACAGATG 
AAACCTGATG ACTCTAAGCC TCCCGTATAT GGTGCCTGCA AGCTCTTGGA CATGGAGCTG 
GAAATGGCTT TTTTTGTAGG CCCTGGAAAC AGATTGGGAG AGCCGATCCC CATTTCCAAG 
GCCCATGAGC ACATTTTTGG AATGGTCCTT ATGAACGACT GGAGTGCACG AGACATTCAG 
AAGTGGGAGT ATGTCCCTCT CGGGCCATTC CTTGGGAAGA GTTTTGGGAC CACTGTCTCT 
CCGTGGGTGG TGCCCATGGA TGCTCTCATG CCCTTTGCTG TGCCCAACCC GAAGCAGGAC 
CCCAGGCCCC TGCCGTATCT GTGCCATGAC GAGCCCTACA CATTTGACAT CAACCTCTCT 
GTTAACCTGA AAGGAGAAGG AATGAGCCAG GCGGCTACCA TATGCAAGTC CAATTTTAAG 
TACATGTACT GGACGATGCT GCAGCAGCTC ACTCACCACT CTGTCAACGG CTGCAACCTG 
CGGCCGGGGG ACCTCCTGGC TTCTGGGACC ATCAGCGGGC CGGAGCCAGA AAACTTCGGC 
TCCATGTTGG AACTGTCGTG GAAGGGAACG AAGCCCATAG ACCTGGGGAA TGGTCAGACC 
AGGAAGTTTC TGCTGGACGG GGATGAAGTC ATCATAACAG GGTACTGCCA GGGGGATGGT 
TACCGCATCG GCTTTGGCCA GTGTGCTGGA AAAGTGCTGC CTGCTCTCCT GCCATCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Molecular Aspects of the FAH Mutations Involved in HT1 Disease.
Advances in experimental medicine and biology95925-48(2017)
Morrow G,Angileri F,Tanguay RM

Silent Tyrosinemia Type I Without Elevated Tyrosine or Succinylacetone Associated with Liver Cirrhosis and Hepatocellular Carcinoma.
Human mutation37(10)1097-105(2016 10)
Blackburn PR,Hickey RD,Nace RA,Giama NH,Kraft DL,Bordner AJ,Chaiteerakij R,McCormick JB,Radulovic M,Graham RP,Torbenson MS,Tortorelli S,Scott CR,Lindor NM,Milliner DS,Oglesbee D,Al-Qabandi W,Grompe M,Gavrilov DK,El-Youssef M,Clark KJ,Atwal PS,Roberts LR,Klee EW,Ekker SC

Direct sequencing of FAH gene in Pakistani tyrosinemia type 1 families reveals a novel mutation.
Journal of pediatric endocrinology & metabolism : JPEM29(3)327-32(2016 Mar)
Ijaz S,Zahoor MY,Imran M,Afzal S,Bhinder MA,Ullah I,Cheema HA,Ramzan K,Shehzad W

Tyrosinemia type 1: a rare and forgotten cause of reversible hypertrophic cardiomyopathy in infancy.
BMC research notes6362(2013 Sep)
Mohamed S,Kambal MA,Al Jurayyan NA,Al-Nemri A,Babiker A,Hasanato R,Al-Jarallah AS

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FAH cDNA ORF clone, Homo sapiens(human)

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gRNAs

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Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

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ORF Insert Sequence:

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