FABP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FABP1
Entrez Gene ID	2168
Full Name	fatty acid binding protein 1
Synonyms	FABPL,L-FABP
General protein information	Preferred Names fatty acid binding protein 1 Names fatty acid-binding protein, liver fatty acid binding protein 1, liver liver-type fatty acid-binding protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p11.2
Summary	This gene encodes the fatty acid binding protein found in liver. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. This protein and FABP6 (the ileal fatty acid binding protein) are also able to bind bile acids. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Mar 2011].
Disorder MIM:	134650

mRNA and Protein(s)

mRNA	Protein	Name
NM_001443.3	NP_001434.1	fatty acid-binding protein, liver
NM_001443.2	NP_001434.1	fatty acid-binding protein, liver

Pathways from BioSystems

Homologies

Homo sapiens (human)	FABP1	NP_001434.1
Xenopus tropicalis (tropical clawed frog)	fabp1	NP_001116883.1
Mus musculus (house mouse)	Fabp1	NP_059095.1
Gallus gallus (chicken)	FABP1	NP_989523.1
Canis lupus familiaris (dog)	FABP1	XP_005630521.1
Bos taurus (cattle)	FABP1	NP_787011.1
Danio rerio (zebrafish)	fabp1a	NP_001038177.1
Pan troglodytes (chimpanzee)	FABP1	XP_001140263.1
Rattus norvegicus (Norway rat)	Fabp1	NP_036688.1

Gene Ontology
Bibliography

Related articles in PubMed

FABP1 knockdown in human enterocytes impairs proliferation and alters lipid metabolism.
Rodriguez Sawicki L, Bottasso Arias NM, Scaglia N, Falomir Lockhart LJ, Franchini GR, Storch J, C?rsico B
Biochimica et biophysica acta1862(12)1587-1594(2017 12)

Urine liver fatty acid binding protein and chronic kidney disease progression.
Khatir DS, Bendtsen MD, Birn H, N?rregaard R, Ivarsen P, Jespersen B, Buus NH
Scandinavian journal of clinical and laboratory investigation77(7)549-554(2017 Nov)

Multiple MicroRNAs Ameliorate Hepatocyte Steatosis and Injury by Suppressing FABP1 Expression.
Wu YL, Zhu YB, Huang RD, Peng XE, Lin X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology44(6)2243-2255(2017)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

studies indicate that FABP1 is essential for proper lipid metabolism in differentiated enterocytes, particularly concerning fatty acids uptake and its basolateral secretion.
Title: FABP1 knockdown in human enterocytes impairs proliferation and alters lipid metabolism.

A high resolution NMR comparative molecular analysis of L-FABP T94T and L-FABP T94A in their unbound states and in the presence of representative ligands of the fatty acid and bile acid classes showed that threonine to alanine replacement did not result in strongly perturbed structural and dynamic features, although differences in oleic acid binding by the two variants were detected.
Title: Molecular differences between human liver fatty acid binding protein and its T94A variant in their unbound and lipid-bound states.

CDH5 and FABP1 expression levels were both elevated in drug-induced liver injury.
Title: Elevated levels of circulating CDH5 and FABP1 in association with human drug-induced liver injury.

analysis of structural, dynamic, and binding properties of the liver fatty acid binding protein (LFABP) in crowded solutions
Title: Effects of macromolecular crowding on a small lipid binding protein probed at the single-amino acid level.

Studies show that despite overall tertiary structure similarity, the hFABP1 differs significantly from rat FABP1 in secondary structure, much larger ligand binding cavity, and affinities/specificities for some ligands. Moreover, while both mouse and hFABP1 mediate ligand induction of PPARA, they differ markedly in genes induced. hFABP1 T94A variant is associated with altered body mass index.[review]
Title: Fatty Acid Binding Protein-1 (FABP1) and the Human FABP1 T94A Variant: Roles in the Endocannabinoid System and Dyslipidemias.

The following FABP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FABP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu10154	NM_001443.3 Latest version!	Homo sapiens fatty acid binding protein 1 (FABP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu10154	NM_001443.2	Homo sapiens fatty acid binding protein 1 (FABP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FABP1 ( NM_001443.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001434.1 Homo sapiens fatty acid binding protein 1 (FABP1), mRNA.

Price & Availability↑

CloneID	OHu10154
Clone ID Related Accession (Same CDS sequence)	NM_001443.3 , NM_001443.2
Accession Version	NM_001443.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-31
Organism	Homo sapiens(human)
Product	fatty acid-binding protein, liver
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC022287.1, M10617.1 and BP263155.1. On May 17, 2019 this sequence version replaced NM_001443.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP328913.1, BM768288.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000295834.8/ ENSP00000295834.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAGTTTCT CCGGCAAGTA CCAACTGCAG AGCCAGGAAA ACTTTGAAGC CTTCATGAAG 
GCAATCGGTC TGCCGGAAGA GCTCATCCAG AAGGGGAAGG ATATCAAGGG GGTGTCGGAA 
ATCGTGCAGA ATGGGAAGCA CTTCAAGTTC ACCATCACCG CTGGGTCCAA AGTGATCCAA 
AACGAATTCA CGGTGGGGGA GGAATGTGAG CTGGAGACAA TGACAGGGGA GAAAGTCAAG 
ACAGTGGTTC AGTTGGAAGG TGACAATAAA CTGGTGACAA CTTTCAAAAA CATCAAGTCT 
GTGACCGAAC TCAACGGCGA CATAATCACC AATACCATGA CATTGGGTGA CATTGTCTTC 
AAGAGAATCA GCAAGAGAAT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001434.1
CDS	46..429
Translation	MSFSGKYQLQSQENFEAFMKAIGLPEELIQKGKDIKGVSEIVQNGKHFKFTITAGSKVIQNEFTVGEECELETMTGEKVKTVVQLEGDNKLVTTFKNIKSVTELNGDIITNTMTLGDIVFKRISKRI

Target ORF information:

RefSeq Version	NM_001443.3
Organism	Homo sapiens(human)
Definition	Homo sapiens fatty acid binding protein 1 (FABP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001443.3

ORF Insert Sequence:

ATGAGTTTCT CCGGCAAGTA CCAACTGCAG AGCCAGGAAA ACTTTGAAGC CTTCATGAAG 
GCAATCGGTC TGCCGGAAGA GCTCATCCAG AAGGGGAAGG ATATCAAGGG GGTGTCGGAA 
ATCGTGCAGA ATGGGAAGCA CTTCAAGTTC ACCATCACCG CTGGGTCCAA AGTGATCCAA 
AACGAATTCA CGGTGGGGGA GGAATGTGAG CTGGAGACAA TGACAGGGGA GAAAGTCAAG 
ACAGTGGTTC AGTTGGAAGG TGACAATAAA CTGGTGACAA CTTTCAAAAA CATCAAGTCT 
GTGACCGAAC TCAACGGCGA CATAATCACC AATACCATGA CATTGGGTGA CATTGTCTTC 
AAGAGAATCA GCAAGAGAAT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FABP1 ( NM_001443.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001434.1 Homo sapiens fatty acid binding protein 1 (FABP1), mRNA.

Price & Availability↑

CloneID	OHu10154
Clone ID Related Accession (Same CDS sequence)	NM_001443.3 , NM_001443.2
Accession Version	NM_001443.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 384bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	fatty acid-binding protein, liver
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AA345359.1, BC022287.1, M10617.1 and BP263155.1. On Mar 10, 2011 this sequence version replaced NM_001443.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AV685486.1, AV690098.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END##

ATGAGTTTCT CCGGCAAGTA CCAACTGCAG AGCCAGGAAA ACTTTGAAGC CTTCATGAAG 
GCAATCGGTC TGCCGGAAGA GCTCATCCAG AAGGGGAAGG ATATCAAGGG GGTGTCGGAA 
ATCGTGCAGA ATGGGAAGCA CTTCAAGTTC ACCATCACCG CTGGGTCCAA AGTGATCCAA 
AACGAATTCA CGGTGGGGGA GGAATGTGAG CTGGAGACAA TGACAGGGGA GAAAGTCAAG 
ACAGTGGTTC AGTTGGAAGG TGACAATAAA CTGGTGACAA CTTTCAAAAA CATCAAGTCT 
GTGACCGAAC TCAACGGCGA CATAATCACC AATACCATGA CATTGGGTGA CATTGTCTTC 
AAGAGAATCA GCAAGAGAAT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001434.1
CDS	115..498
Translation	MSFSGKYQLQSQENFEAFMKAIGLPEELIQKGKDIKGVSEIVQNGKHFKFTITAGSKVIQNEFTVGEECELETMTGEKVKTVVQLEGDNKLVTTFKNIKSVTELNGDIITNTMTLGDIVFKRISKRI

Target ORF information:

RefSeq Version	NM_001443.2
Organism	Homo sapiens(human)
Definition	Homo sapiens fatty acid binding protein 1 (FABP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001443.2

ORF Insert Sequence:

ATGAGTTTCT CCGGCAAGTA CCAACTGCAG AGCCAGGAAA ACTTTGAAGC CTTCATGAAG 
GCAATCGGTC TGCCGGAAGA GCTCATCCAG AAGGGGAAGG ATATCAAGGG GGTGTCGGAA 
ATCGTGCAGA ATGGGAAGCA CTTCAAGTTC ACCATCACCG CTGGGTCCAA AGTGATCCAA 
AACGAATTCA CGGTGGGGGA GGAATGTGAG CTGGAGACAA TGACAGGGGA GAAAGTCAAG 
ACAGTGGTTC AGTTGGAAGG TGACAATAAA CTGGTGACAA CTTTCAAAAA CATCAAGTCT 
GTGACCGAAC TCAACGGCGA CATAATCACC AATACCATGA CATTGGGTGA CATTGTCTTC 
AAGAGAATCA GCAAGAGAAT TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

FABP1 knockdown in human enterocytes impairs proliferation and alters lipid metabolism.
Biochimica et biophysica acta1862(12)1587-1594(2017 12)
Rodriguez Sawicki L,Bottasso Arias NM,Scaglia N,Falomir Lockhart LJ,Franchini GR,Storch J,C?rsico B

Urine liver fatty acid binding protein and chronic kidney disease progression.
Scandinavian journal of clinical and laboratory investigation77(7)549-554(2017 Nov)
Khatir DS,Bendtsen MD,Birn H,N?rregaard R,Ivarsen P,Jespersen B,Buus NH

Multiple MicroRNAs Ameliorate Hepatocyte Steatosis and Injury by Suppressing FABP1 Expression.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology44(6)2243-2255(2017)
Wu YL,Zhu YB,Huang RD,Peng XE,Lin X

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FABP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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