F10 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	F10
Entrez Gene ID	2159
Full Name	coagulation factor X
Synonyms	FX,FXA
General protein information	Preferred Names coagulation factor X Names coagulation factor X Stuart-Prower factor factor Xa prothrombinase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 13 Map Location: 13q34
Summary	This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015].
Disorder MIM:	613872
Disorder Html:	Factor X deficiency, 227600 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001312675.1	NP_001299604.1	coagulation factor X isoform 3 precursor
NM_000504.3	NP_000495.1	coagulation factor X isoform 1 preproprotein
NM_001312674.1	NP_001299603.1	coagulation factor X isoform 2 precursor
NM_000504.4	NP_000495.1	coagulation factor X isoform 1 preproprotein
NM_001312674.2	NP_001299603.1	coagulation factor X isoform 2 precursor
NM_001312675.2	NP_001299604.1	coagulation factor X isoform 3 precursor

Pathways from BioSystems

Homologies

Homo sapiens (human)	F10	NP_000495.1
Canis lupus familiaris (dog)	F10	XP_534191.1
Xenopus tropicalis (tropical clawed frog)	f10	NP_001015728.1
Rattus norvegicus (Norway rat)	F10	NP_058839.1
Mus musculus (house mouse)	F10	NP_031998.3
Drosophila melanogaster (fruit fly)	CG11836	NP_001163718.3
Pan troglodytes (chimpanzee)	F10	XP_509746.2
Gallus gallus (chicken)	F10	NP_990353.1
Danio rerio (zebrafish)	f10	NP_958870.2
	F10	NP_001098054.1
Bos taurus (cattle)	F10	NP_001073682.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP004570	XP_313874.5

Gene Ontology
Bibliography

Related articles in PubMed

Activities of Thrombin and Factor Xa are essential for replication of Hepatitis E virus and are possibly implicated in the ORF1 polyprotein processing.
Kanade GD, Pingale KD, Karpe YA
Journal of virology(2018 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

A coagulation initiating pathway is revealed in which the TF-FVIIa-nascent FXa complex activates FVIII apart from thrombin feedback.
Title: Selective factor VIII activation by the tissue factor-factor VIIa-factor Xa complex.

Data suggest oxidized lipid vesicles with phosphatidylserine/polyunsaturated fatty acids promote inactivation of ZPI-PZ complex or free ZPI; binding of PZ-complexed or free ZPI to oxidized vesicles mediates inactivation of ZPI (an inhibitor of FXa); blocking heparin- (anticoagulant-)binding site on ZPI interferes with binding to lipid or PZ. (ZPI = protein Z-dependent protease inhibitor; PZ = protein Z; FXa = factor Xa)
Title: Lipid oxidation inactivates the anticoagulant function of protein Z-dependent protease inhibitor (ZPI).

zymogen-like factor Xa variants are conformationally dynamic and ligands such as its cofactor, factor Va, stabilize the molecule rescuing procoagulant activity. At the site of vascular injury, the variants in the presence of factor Va serve as effective prohemostatic agents.
Title: Rendering factor Xa zymogen-like as a therapeutic strategy to treat bleeding.

Data suggest that, for all coagulation proteins tested (prothrombin, factor X, activated factor VII, activated protein C), tighter binding to lipid bilayers (lower Kd) is observed as the proportion of anionic phospholipid increases. These studies were conducted in high-throughput screening using phospholipid bilayers in nanodiscs with multiplexed silicon photonic sensor (micro-ring resonator) array technology.
Title: Multiplexed silicon photonic sensor arrays enable facile characterization of coagulation protein binding to nanodiscs with variable lipid content.

annexin A2 contributes to lung injury and fibrotic disease by mediating the fibrogenic actions of FXa.
Title: Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity.

The following F10 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the F10 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24185	NM_000504.4 Latest version!	Homo sapiens coagulation factor X (F10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu47413	NM_001312674.2 Latest version!	Homo sapiens coagulation factor X (F10), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu47414	NM_001312675.2 Latest version!	Homo sapiens coagulation factor X (F10), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu24185	NM_000504.3	Homo sapiens coagulation factor X (F10), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu47413	NM_001312674.1	Homo sapiens coagulation factor X (F10), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu47414	NM_001312675.1	Homo sapiens coagulation factor X (F10), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

F10 ( NM_000504.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_000495.1 Homo sapiens coagulation factor X (F10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24185
Clone ID Related Accession (Same CDS sequence)	NM_000504.3 , NM_000504.4
Accession Version	NM_000504.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1467bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	coagulation factor X isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB158437.1, BC046125.1 and AL137002.19. On Mar 2, 2006 this sequence version replaced NM_000504.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC046125.1, AK313798.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGGCGCC CACTGCACCT CGTCCTGCTC AGTGCCTCCC TGGCTGGCCT CCTGCTGCTC 
GGGGAAAGTC TGTTCATCCG CAGGGAGCAG GCCAACAACA TCCTGGCGAG GGTCACGAGG 
GCCAATTCCT TTCTTGAAGA GATGAAGAAA GGACACCTCG AAAGAGAGTG CATGGAAGAG 
ACCTGCTCAT ACGAAGAGGC CCGCGAGGTC TTTGAGGACA GCGACAAGAC GAATGAATTC 
TGGAATAAAT ACAAAGATGG CGACCAGTGT GAGACCAGTC CTTGCCAGAA CCAGGGCAAA 
TGTAAAGACG GCCTCGGGGA ATACACCTGC ACCTGTTTAG AAGGATTCGA AGGCAAAAAC 
TGTGAATTAT TCACACGGAA GCTCTGCAGC CTGGACAACG GGGACTGTGA CCAGTTCTGC 
CACGAGGAAC AGAACTCTGT GGTGTGCTCC TGCGCCCGCG GGTACACCCT GGCTGACAAC 
GGCAAGGCCT GCATTCCCAC AGGGCCCTAC CCCTGTGGGA AACAGACCCT GGAACGCAGG 
AAGAGGTCAG TGGCCCAGGC CACCAGCAGC AGCGGGGAGG CCCCTGACAG CATCACATGG 
AAGCCATATG ATGCAGCCGA CCTGGACCCC ACCGAGAACC CCTTCGACCT GCTTGACTTC 
AACCAGACGC AGCCTGAGAG GGGCGACAAC AACCTCACCA GGATCGTGGG AGGCCAGGAA 
TGCAAGGACG GGGAGTGTCC CTGGCAGGCC CTGCTCATCA ATGAGGAAAA CGAGGGTTTC 
TGTGGTGGAA CCATTCTGAG CGAGTTCTAC ATCCTAACGG CAGCCCACTG TCTCTACCAA 
GCCAAGAGAT TCAAGGTGAG GGTAGGGGAC CGGAACACGG AGCAGGAGGA GGGCGGTGAG 
GCGGTGCACG AGGTGGAGGT GGTCATCAAG CACAACCGGT TCACAAAGGA GACCTATGAC 
TTCGACATCG CCGTGCTCCG GCTCAAGACC CCCATCACCT TCCGCATGAA CGTGGCGCCT 
GCCTGCCTCC CCGAGCGTGA CTGGGCCGAG TCCACGCTGA TGACGCAGAA GACGGGGATT 
GTGAGCGGCT TCGGGCGCAC CCACGAGAAG GGCCGGCAGT CCACCAGGCT CAAGATGCTG 
GAGGTGCCCT ACGTGGACCG CAACAGCTGC AAGCTGTCCA GCAGCTTCAT CATCACCCAG 
AACATGTTCT GTGCCGGCTA CGACACCAAG CAGGAGGATG CCTGCCAGGG GGACAGCGGG 
GGCCCGCACG TCACCCGCTT CAAGGACACC TACTTCGTGA CAGGCATCGT CAGCTGGGGA 
GAGGGCTGTG CCCGTAAGGG GAAGTACGGG ATCTACACCA AGGTCACCGC CTTCCTCAAG 
TGGATCGACA GGTCCATGAA AACCAGGGGC TTGCCCAAGG CCAAGAGCCA TGCCCCGGAG 
GTCATAACGT CCTCTCCATT AAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000495.1
CDS	58..1524
Translation	MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK

Target ORF information:

RefSeq Version	NM_000504.3
Organism	Homo sapiens(human)
Definition	Homo sapiens coagulation factor X (F10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000504.3

ORF Insert Sequence:

ATGGGGCGCC CACTGCACCT CGTCCTGCTC AGTGCCTCCC TGGCTGGCCT CCTGCTGCTC 
GGGGAAAGTC TGTTCATCCG CAGGGAGCAG GCCAACAACA TCCTGGCGAG GGTCACGAGG 
GCCAATTCCT TTCTTGAAGA GATGAAGAAA GGACACCTCG AAAGAGAGTG CATGGAAGAG 
ACCTGCTCAT ACGAAGAGGC CCGCGAGGTC TTTGAGGACA GCGACAAGAC GAATGAATTC 
TGGAATAAAT ACAAAGATGG CGACCAGTGT GAGACCAGTC CTTGCCAGAA CCAGGGCAAA 
TGTAAAGACG GCCTCGGGGA ATACACCTGC ACCTGTTTAG AAGGATTCGA AGGCAAAAAC 
TGTGAATTAT TCACACGGAA GCTCTGCAGC CTGGACAACG GGGACTGTGA CCAGTTCTGC 
CACGAGGAAC AGAACTCTGT GGTGTGCTCC TGCGCCCGCG GGTACACCCT GGCTGACAAC 
GGCAAGGCCT GCATTCCCAC AGGGCCCTAC CCCTGTGGGA AACAGACCCT GGAACGCAGG 
AAGAGGTCAG TGGCCCAGGC CACCAGCAGC AGCGGGGAGG CCCCTGACAG CATCACATGG 
AAGCCATATG ATGCAGCCGA CCTGGACCCC ACCGAGAACC CCTTCGACCT GCTTGACTTC 
AACCAGACGC AGCCTGAGAG GGGCGACAAC AACCTCACCA GGATCGTGGG AGGCCAGGAA 
TGCAAGGACG GGGAGTGTCC CTGGCAGGCC CTGCTCATCA ATGAGGAAAA CGAGGGTTTC 
TGTGGTGGAA CCATTCTGAG CGAGTTCTAC ATCCTAACGG CAGCCCACTG TCTCTACCAA 
GCCAAGAGAT TCAAGGTGAG GGTAGGGGAC CGGAACACGG AGCAGGAGGA GGGCGGTGAG 
GCGGTGCACG AGGTGGAGGT GGTCATCAAG CACAACCGGT TCACAAAGGA GACCTATGAC 
TTCGACATCG CCGTGCTCCG GCTCAAGACC CCCATCACCT TCCGCATGAA CGTGGCGCCT 
GCCTGCCTCC CCGAGCGTGA CTGGGCCGAG TCCACGCTGA TGACGCAGAA GACGGGGATT 
GTGAGCGGCT TCGGGCGCAC CCACGAGAAG GGCCGGCAGT CCACCAGGCT CAAGATGCTG 
GAGGTGCCCT ACGTGGACCG CAACAGCTGC AAGCTGTCCA GCAGCTTCAT CATCACCCAG 
AACATGTTCT GTGCCGGCTA CGACACCAAG CAGGAGGATG CCTGCCAGGG GGACAGCGGG 
GGCCCGCACG TCACCCGCTT CAAGGACACC TACTTCGTGA CAGGCATCGT CAGCTGGGGA 
GAGGGCTGTG CCCGTAAGGG GAAGTACGGG ATCTACACCA AGGTCACCGC CTTCCTCAAG 
TGGATCGACA GGTCCATGAA AACCAGGGGC TTGCCCAAGG CCAAGAGCCA TGCCCCGGAG 
GTCATAACGT CCTCTCCATT AAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

F10 ( NM_000504.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_000495.1 Homo sapiens coagulation factor X (F10), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24185
Clone ID Related Accession (Same CDS sequence)	NM_000504.3 , NM_000504.4
Accession Version	NM_000504.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1467bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-20
Organism	Homo sapiens(human)
Product	coagulation factor X isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB158437.1, BC046125.1 and AL137002.19. On May 17, 2019 this sequence version replaced NM_000504.3. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC046125.1, M57285.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1968189 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000375559.8/ ENSP00000364709.3 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGGCGCC CACTGCACCT CGTCCTGCTC AGTGCCTCCC TGGCTGGCCT CCTGCTGCTC 
GGGGAAAGTC TGTTCATCCG CAGGGAGCAG GCCAACAACA TCCTGGCGAG GGTCACGAGG 
GCCAATTCCT TTCTTGAAGA GATGAAGAAA GGACACCTCG AAAGAGAGTG CATGGAAGAG 
ACCTGCTCAT ACGAAGAGGC CCGCGAGGTC TTTGAGGACA GCGACAAGAC GAATGAATTC 
TGGAATAAAT ACAAAGATGG CGACCAGTGT GAGACCAGTC CTTGCCAGAA CCAGGGCAAA 
TGTAAAGACG GCCTCGGGGA ATACACCTGC ACCTGTTTAG AAGGATTCGA AGGCAAAAAC 
TGTGAATTAT TCACACGGAA GCTCTGCAGC CTGGACAACG GGGACTGTGA CCAGTTCTGC 
CACGAGGAAC AGAACTCTGT GGTGTGCTCC TGCGCCCGCG GGTACACCCT GGCTGACAAC 
GGCAAGGCCT GCATTCCCAC AGGGCCCTAC CCCTGTGGGA AACAGACCCT GGAACGCAGG 
AAGAGGTCAG TGGCCCAGGC CACCAGCAGC AGCGGGGAGG CCCCTGACAG CATCACATGG 
AAGCCATATG ATGCAGCCGA CCTGGACCCC ACCGAGAACC CCTTCGACCT GCTTGACTTC 
AACCAGACGC AGCCTGAGAG GGGCGACAAC AACCTCACCA GGATCGTGGG AGGCCAGGAA 
TGCAAGGACG GGGAGTGTCC CTGGCAGGCC CTGCTCATCA ATGAGGAAAA CGAGGGTTTC 
TGTGGTGGAA CCATTCTGAG CGAGTTCTAC ATCCTAACGG CAGCCCACTG TCTCTACCAA 
GCCAAGAGAT TCAAGGTGAG GGTAGGGGAC CGGAACACGG AGCAGGAGGA GGGCGGTGAG 
GCGGTGCACG AGGTGGAGGT GGTCATCAAG CACAACCGGT TCACAAAGGA GACCTATGAC 
TTCGACATCG CCGTGCTCCG GCTCAAGACC CCCATCACCT TCCGCATGAA CGTGGCGCCT 
GCCTGCCTCC CCGAGCGTGA CTGGGCCGAG TCCACGCTGA TGACGCAGAA GACGGGGATT 
GTGAGCGGCT TCGGGCGCAC CCACGAGAAG GGCCGGCAGT CCACCAGGCT CAAGATGCTG 
GAGGTGCCCT ACGTGGACCG CAACAGCTGC AAGCTGTCCA GCAGCTTCAT CATCACCCAG 
AACATGTTCT GTGCCGGCTA CGACACCAAG CAGGAGGATG CCTGCCAGGG GGACAGCGGG 
GGCCCGCACG TCACCCGCTT CAAGGACACC TACTTCGTGA CAGGCATCGT CAGCTGGGGA 
GAGGGCTGTG CCCGTAAGGG GAAGTACGGG ATCTACACCA AGGTCACCGC CTTCCTCAAG 
TGGATCGACA GGTCCATGAA AACCAGGGGC TTGCCCAAGG CCAAGAGCCA TGCCCCGGAG 
GTCATAACGT CCTCTCCATT AAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000495.1
CDS	58..1524
Translation	MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK

Target ORF information:

RefSeq Version	NM_000504.4
Organism	Homo sapiens(human)
Definition	Homo sapiens coagulation factor X (F10), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000504.4

ORF Insert Sequence:

ATGGGGCGCC CACTGCACCT CGTCCTGCTC AGTGCCTCCC TGGCTGGCCT CCTGCTGCTC 
GGGGAAAGTC TGTTCATCCG CAGGGAGCAG GCCAACAACA TCCTGGCGAG GGTCACGAGG 
GCCAATTCCT TTCTTGAAGA GATGAAGAAA GGACACCTCG AAAGAGAGTG CATGGAAGAG 
ACCTGCTCAT ACGAAGAGGC CCGCGAGGTC TTTGAGGACA GCGACAAGAC GAATGAATTC 
TGGAATAAAT ACAAAGATGG CGACCAGTGT GAGACCAGTC CTTGCCAGAA CCAGGGCAAA 
TGTAAAGACG GCCTCGGGGA ATACACCTGC ACCTGTTTAG AAGGATTCGA AGGCAAAAAC 
TGTGAATTAT TCACACGGAA GCTCTGCAGC CTGGACAACG GGGACTGTGA CCAGTTCTGC 
CACGAGGAAC AGAACTCTGT GGTGTGCTCC TGCGCCCGCG GGTACACCCT GGCTGACAAC 
GGCAAGGCCT GCATTCCCAC AGGGCCCTAC CCCTGTGGGA AACAGACCCT GGAACGCAGG 
AAGAGGTCAG TGGCCCAGGC CACCAGCAGC AGCGGGGAGG CCCCTGACAG CATCACATGG 
AAGCCATATG ATGCAGCCGA CCTGGACCCC ACCGAGAACC CCTTCGACCT GCTTGACTTC 
AACCAGACGC AGCCTGAGAG GGGCGACAAC AACCTCACCA GGATCGTGGG AGGCCAGGAA 
TGCAAGGACG GGGAGTGTCC CTGGCAGGCC CTGCTCATCA ATGAGGAAAA CGAGGGTTTC 
TGTGGTGGAA CCATTCTGAG CGAGTTCTAC ATCCTAACGG CAGCCCACTG TCTCTACCAA 
GCCAAGAGAT TCAAGGTGAG GGTAGGGGAC CGGAACACGG AGCAGGAGGA GGGCGGTGAG 
GCGGTGCACG AGGTGGAGGT GGTCATCAAG CACAACCGGT TCACAAAGGA GACCTATGAC 
TTCGACATCG CCGTGCTCCG GCTCAAGACC CCCATCACCT TCCGCATGAA CGTGGCGCCT 
GCCTGCCTCC CCGAGCGTGA CTGGGCCGAG TCCACGCTGA TGACGCAGAA GACGGGGATT 
GTGAGCGGCT TCGGGCGCAC CCACGAGAAG GGCCGGCAGT CCACCAGGCT CAAGATGCTG 
GAGGTGCCCT ACGTGGACCG CAACAGCTGC AAGCTGTCCA GCAGCTTCAT CATCACCCAG 
AACATGTTCT GTGCCGGCTA CGACACCAAG CAGGAGGATG CCTGCCAGGG GGACAGCGGG 
GGCCCGCACG TCACCCGCTT CAAGGACACC TACTTCGTGA CAGGCATCGT CAGCTGGGGA 
GAGGGCTGTG CCCGTAAGGG GAAGTACGGG ATCTACACCA AGGTCACCGC CTTCCTCAAG 
TGGATCGACA GGTCCATGAA AACCAGGGGC TTGCCCAAGG CCAAGAGCCA TGCCCCGGAG 
GTCATAACGT CCTCTCCATT AAAGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

F10 ( NM_001312674.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001299603.1 Homo sapiens coagulation factor X (F10), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu47413
Clone ID Related Accession (Same CDS sequence)	NM_001312674.1 , NM_001312674.2
Accession Version	NM_001312674.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1335bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-25
Organism	Homo sapiens(human)
Product	coagulation factor X isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB158437.1, CD013940.1, AL137002.19 and BC046125.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD013940.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGGCGCC CACTGCACCT CGTCCTGCTC AGTGCCTCCC TGGCTGGCCT CCTGCTGCTC 
GGGGAAAGTC TGTTCATCCG CAGGGAGCAG GCCAACAACA TCCTGGCGAG GGTCACGAGG 
GCCAATTCCT TTCTTGAAGA GATGAAGAAA GGACACCTCG AAAGAGAGTG CATGGAAGAG 
ACCTGCTCAT ACGAAGAGGC CCGCGAGGTC TTTGAGGACA GCGACAAGAC GAATGAATTC 
TGGAATAAAT ACAAAGATGG CGACCAGTGT GAGACCAGTC CTTGCCAGAA CCAGGGCAAA 
TGTAAAGACG GCCTCGGGGA ATACACCTGC ACCTGTTTAG AAGGATTCGA AGGCAAAAAC 
TGTGAATTAT GGCCCTACCC CTGTGGGAAA CAGACCCTGG AACGCAGGAA GAGGTCAGTG 
GCCCAGGCCA CCAGCAGCAG CGGGGAGGCC CCTGACAGCA TCACATGGAA GCCATATGAT 
GCAGCCGACC TGGACCCCAC CGAGAACCCC TTCGACCTGC TTGACTTCAA CCAGACGCAG 
CCTGAGAGGG GCGACAACAA CCTCACCAGG ATCGTGGGAG GCCAGGAATG CAAGGACGGG 
GAGTGTCCCT GGCAGGCCCT GCTCATCAAT GAGGAAAACG AGGGTTTCTG TGGTGGAACC 
ATTCTGAGCG AGTTCTACAT CCTAACGGCA GCCCACTGTC TCTACCAAGC CAAGAGATTC 
AAGGTGAGGG TAGGGGACCG GAACACGGAG CAGGAGGAGG GCGGTGAGGC GGTGCACGAG 
GTGGAGGTGG TCATCAAGCA CAACCGGTTC ACAAAGGAGA CCTATGACTT CGACATCGCC 
GTGCTCCGGC TCAAGACCCC CATCACCTTC CGCATGAACG TGGCGCCTGC CTGCCTCCCC 
GAGCGTGACT GGGCCGAGTC CACGCTGATG ACGCAGAAGA CGGGGATTGT GAGCGGCTTC 
GGGCGCACCC ACGAGAAGGG CCGGCAGTCC ACCAGGCTCA AGATGCTGGA GGTGCCCTAC 
GTGGACCGCA ACAGCTGCAA GCTGTCCAGC AGCTTCATCA TCACCCAGAA CATGTTCTGT 
GCCGGCTACG ACACCAAGCA GGAGGATGCC TGCCAGGGGG ACAGCGGGGG CCCGCACGTC 
ACCCGCTTCA AGGACACCTA CTTCGTGACA GGCATCGTCA GCTGGGGAGA GGGCTGTGCC 
CGTAAGGGGA AGTACGGGAT CTACACCAAG GTCACCGCCT TCCTCAAGTG GATCGACAGG 
TCCATGAAAA CCAGGGGCTT GCCCAAGGCC AAGAGCCATG CCCCGGAGGT CATAACGTCC 
TCTCCATTAA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001299603.1
CDS	58..1392
Translation	MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELWPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK

Target ORF information:

RefSeq Version	NM_001312674.1
Organism	Homo sapiens(human)
Definition	Homo sapiens coagulation factor X (F10), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001312674.1

ORF Insert Sequence:

ATGGGGCGCC CACTGCACCT CGTCCTGCTC AGTGCCTCCC TGGCTGGCCT CCTGCTGCTC 
GGGGAAAGTC TGTTCATCCG CAGGGAGCAG GCCAACAACA TCCTGGCGAG GGTCACGAGG 
GCCAATTCCT TTCTTGAAGA GATGAAGAAA GGACACCTCG AAAGAGAGTG CATGGAAGAG 
ACCTGCTCAT ACGAAGAGGC CCGCGAGGTC TTTGAGGACA GCGACAAGAC GAATGAATTC 
TGGAATAAAT ACAAAGATGG CGACCAGTGT GAGACCAGTC CTTGCCAGAA CCAGGGCAAA 
TGTAAAGACG GCCTCGGGGA ATACACCTGC ACCTGTTTAG AAGGATTCGA AGGCAAAAAC 
TGTGAATTAT GGCCCTACCC CTGTGGGAAA CAGACCCTGG AACGCAGGAA GAGGTCAGTG 
GCCCAGGCCA CCAGCAGCAG CGGGGAGGCC CCTGACAGCA TCACATGGAA GCCATATGAT 
GCAGCCGACC TGGACCCCAC CGAGAACCCC TTCGACCTGC TTGACTTCAA CCAGACGCAG 
CCTGAGAGGG GCGACAACAA CCTCACCAGG ATCGTGGGAG GCCAGGAATG CAAGGACGGG 
GAGTGTCCCT GGCAGGCCCT GCTCATCAAT GAGGAAAACG AGGGTTTCTG TGGTGGAACC 
ATTCTGAGCG AGTTCTACAT CCTAACGGCA GCCCACTGTC TCTACCAAGC CAAGAGATTC 
AAGGTGAGGG TAGGGGACCG GAACACGGAG CAGGAGGAGG GCGGTGAGGC GGTGCACGAG 
GTGGAGGTGG TCATCAAGCA CAACCGGTTC ACAAAGGAGA CCTATGACTT CGACATCGCC 
GTGCTCCGGC TCAAGACCCC CATCACCTTC CGCATGAACG TGGCGCCTGC CTGCCTCCCC 
GAGCGTGACT GGGCCGAGTC CACGCTGATG ACGCAGAAGA CGGGGATTGT GAGCGGCTTC 
GGGCGCACCC ACGAGAAGGG CCGGCAGTCC ACCAGGCTCA AGATGCTGGA GGTGCCCTAC 
GTGGACCGCA ACAGCTGCAA GCTGTCCAGC AGCTTCATCA TCACCCAGAA CATGTTCTGT 
GCCGGCTACG ACACCAAGCA GGAGGATGCC TGCCAGGGGG ACAGCGGGGG CCCGCACGTC 
ACCCGCTTCA AGGACACCTA CTTCGTGACA GGCATCGTCA GCTGGGGAGA GGGCTGTGCC 
CGTAAGGGGA AGTACGGGAT CTACACCAAG GTCACCGCCT TCCTCAAGTG GATCGACAGG 
TCCATGAAAA CCAGGGGCTT GCCCAAGGCC AAGAGCCATG CCCCGGAGGT CATAACGTCC 
TCTCCATTAA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

F10 ( NM_001312674.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001299603.1 Homo sapiens coagulation factor X (F10), transcript variant 2, mRNA.

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CloneID	OHu47413
Clone ID Related Accession (Same CDS sequence)	NM_001312674.1 , NM_001312674.2
Accession Version	NM_001312674.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1335bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-06
Organism	Homo sapiens(human)
Product	coagulation factor X isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB158437.1, CD013940.1, AL137002.19 and BC046125.1. On May 31, 2019 this sequence version replaced NM_001312674.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: CD013940.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGGCGCC CACTGCACCT CGTCCTGCTC AGTGCCTCCC TGGCTGGCCT CCTGCTGCTC 
GGGGAAAGTC TGTTCATCCG CAGGGAGCAG GCCAACAACA TCCTGGCGAG GGTCACGAGG 
GCCAATTCCT TTCTTGAAGA GATGAAGAAA GGACACCTCG AAAGAGAGTG CATGGAAGAG 
ACCTGCTCAT ACGAAGAGGC CCGCGAGGTC TTTGAGGACA GCGACAAGAC GAATGAATTC 
TGGAATAAAT ACAAAGATGG CGACCAGTGT GAGACCAGTC CTTGCCAGAA CCAGGGCAAA 
TGTAAAGACG GCCTCGGGGA ATACACCTGC ACCTGTTTAG AAGGATTCGA AGGCAAAAAC 
TGTGAATTAT GGCCCTACCC CTGTGGGAAA CAGACCCTGG AACGCAGGAA GAGGTCAGTG 
GCCCAGGCCA CCAGCAGCAG CGGGGAGGCC CCTGACAGCA TCACATGGAA GCCATATGAT 
GCAGCCGACC TGGACCCCAC CGAGAACCCC TTCGACCTGC TTGACTTCAA CCAGACGCAG 
CCTGAGAGGG GCGACAACAA CCTCACCAGG ATCGTGGGAG GCCAGGAATG CAAGGACGGG 
GAGTGTCCCT GGCAGGCCCT GCTCATCAAT GAGGAAAACG AGGGTTTCTG TGGTGGAACC 
ATTCTGAGCG AGTTCTACAT CCTAACGGCA GCCCACTGTC TCTACCAAGC CAAGAGATTC 
AAGGTGAGGG TAGGGGACCG GAACACGGAG CAGGAGGAGG GCGGTGAGGC GGTGCACGAG 
GTGGAGGTGG TCATCAAGCA CAACCGGTTC ACAAAGGAGA CCTATGACTT CGACATCGCC 
GTGCTCCGGC TCAAGACCCC CATCACCTTC CGCATGAACG TGGCGCCTGC CTGCCTCCCC 
GAGCGTGACT GGGCCGAGTC CACGCTGATG ACGCAGAAGA CGGGGATTGT GAGCGGCTTC 
GGGCGCACCC ACGAGAAGGG CCGGCAGTCC ACCAGGCTCA AGATGCTGGA GGTGCCCTAC 
GTGGACCGCA ACAGCTGCAA GCTGTCCAGC AGCTTCATCA TCACCCAGAA CATGTTCTGT 
GCCGGCTACG ACACCAAGCA GGAGGATGCC TGCCAGGGGG ACAGCGGGGG CCCGCACGTC 
ACCCGCTTCA AGGACACCTA CTTCGTGACA GGCATCGTCA GCTGGGGAGA GGGCTGTGCC 
CGTAAGGGGA AGTACGGGAT CTACACCAAG GTCACCGCCT TCCTCAAGTG GATCGACAGG 
TCCATGAAAA CCAGGGGCTT GCCCAAGGCC AAGAGCCATG CCCCGGAGGT CATAACGTCC 
TCTCCATTAA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001299603.1
CDS	58..1392
Translation	MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELWPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK

Target ORF information:

RefSeq Version	NM_001312674.2
Organism	Homo sapiens(human)
Definition	Homo sapiens coagulation factor X (F10), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001312674.2

ORF Insert Sequence:

ATGGGGCGCC CACTGCACCT CGTCCTGCTC AGTGCCTCCC TGGCTGGCCT CCTGCTGCTC 
GGGGAAAGTC TGTTCATCCG CAGGGAGCAG GCCAACAACA TCCTGGCGAG GGTCACGAGG 
GCCAATTCCT TTCTTGAAGA GATGAAGAAA GGACACCTCG AAAGAGAGTG CATGGAAGAG 
ACCTGCTCAT ACGAAGAGGC CCGCGAGGTC TTTGAGGACA GCGACAAGAC GAATGAATTC 
TGGAATAAAT ACAAAGATGG CGACCAGTGT GAGACCAGTC CTTGCCAGAA CCAGGGCAAA 
TGTAAAGACG GCCTCGGGGA ATACACCTGC ACCTGTTTAG AAGGATTCGA AGGCAAAAAC 
TGTGAATTAT GGCCCTACCC CTGTGGGAAA CAGACCCTGG AACGCAGGAA GAGGTCAGTG 
GCCCAGGCCA CCAGCAGCAG CGGGGAGGCC CCTGACAGCA TCACATGGAA GCCATATGAT 
GCAGCCGACC TGGACCCCAC CGAGAACCCC TTCGACCTGC TTGACTTCAA CCAGACGCAG 
CCTGAGAGGG GCGACAACAA CCTCACCAGG ATCGTGGGAG GCCAGGAATG CAAGGACGGG 
GAGTGTCCCT GGCAGGCCCT GCTCATCAAT GAGGAAAACG AGGGTTTCTG TGGTGGAACC 
ATTCTGAGCG AGTTCTACAT CCTAACGGCA GCCCACTGTC TCTACCAAGC CAAGAGATTC 
AAGGTGAGGG TAGGGGACCG GAACACGGAG CAGGAGGAGG GCGGTGAGGC GGTGCACGAG 
GTGGAGGTGG TCATCAAGCA CAACCGGTTC ACAAAGGAGA CCTATGACTT CGACATCGCC 
GTGCTCCGGC TCAAGACCCC CATCACCTTC CGCATGAACG TGGCGCCTGC CTGCCTCCCC 
GAGCGTGACT GGGCCGAGTC CACGCTGATG ACGCAGAAGA CGGGGATTGT GAGCGGCTTC 
GGGCGCACCC ACGAGAAGGG CCGGCAGTCC ACCAGGCTCA AGATGCTGGA GGTGCCCTAC 
GTGGACCGCA ACAGCTGCAA GCTGTCCAGC AGCTTCATCA TCACCCAGAA CATGTTCTGT 
GCCGGCTACG ACACCAAGCA GGAGGATGCC TGCCAGGGGG ACAGCGGGGG CCCGCACGTC 
ACCCGCTTCA AGGACACCTA CTTCGTGACA GGCATCGTCA GCTGGGGAGA GGGCTGTGCC 
CGTAAGGGGA AGTACGGGAT CTACACCAAG GTCACCGCCT TCCTCAAGTG GATCGACAGG 
TCCATGAAAA CCAGGGGCTT GCCCAAGGCC AAGAGCCATG CCCCGGAGGT CATAACGTCC 
TCTCCATTAA AGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

F10 ( NM_001312675.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001299604.1 Homo sapiens coagulation factor X (F10), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu47414
Clone ID Related Accession (Same CDS sequence)	NM_001312675.1 , NM_001312675.2
Accession Version	NM_001312675.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	coagulation factor X isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB158437.1, M22613.1 and BC046125.1. On Aug 15, 2015 this sequence version replaced XM_005268298.1. Transcript Variant: This variant (3) uses an alternate splice site in the penultimate exon, compared to variant 1, resulting in differences in the 3' coding region and 3' UTR. It encodes isoform 3 which has a distinct C-terminus, compared to isoform 1. This isoform (3) may undergo proteolytic processing similar to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M22613.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGGCGCC CACTGCACCT CGTCCTGCTC AGTGCCTCCC TGGCTGGCCT CCTGCTGCTC 
GGGGAAAGTC TGTTCATCCG CAGGGAGCAG GCCAACAACA TCCTGGCGAG GGTCACGAGG 
GCCAATTCCT TTCTTGAAGA GATGAAGAAA GGACACCTCG AAAGAGAGTG CATGGAAGAG 
ACCTGCTCAT ACGAAGAGGC CCGCGAGGTC TTTGAGGACA GCGACAAGAC GAATGAATTC 
TGGAATAAAT ACAAAGATGG CGACCAGTGT GAGACCAGTC CTTGCCAGAA CCAGGGCAAA 
TGTAAAGACG GCCTCGGGGA ATACACCTGC ACCTGTTTAG AAGGATTCGA AGGCAAAAAC 
TGTGAATTAT TCACACGGAA GCTCTGCAGC CTGGACAACG GGGACTGTGA CCAGTTCTGC 
CACGAGGAAC AGAACTCTGT GGTGTGCTCC TGCGCCCGCG GGTACACCCT GGCTGACAAC 
GGCAAGGCCT GCATTCCCAC AGGGCCCTAC CCCTGTGGGA AACAGACCCT GGAACGCAGG 
AAGAGGTCAG TGGCCCAGGC CACCAGCAGC AGCGGGGAGG CCCCTGACAG CATCACATGG 
AAGCCATATG ATGCAGCCGA CCTGGACCCC ACCGAGAACC CCTTCGACCT GCTTGACTTC 
AACCAGACGC AGCCTGAGAG GGGCGACAAC AACCTCACCA GGATCGTGGG AGGCCAGGAA 
TGCAAGGACG GGGAGTGTCC CTGGCAGGCC CTGCTCATCA ATGAGGAAAA CGAGGGTTTC 
TGTGGTGGAA CCATTCTGAG CGAGTTCTAC ATCCTAACGG CAGCCCACTG TCTCTACCAA 
GCCAAGAGAT TCAAGGGGAC CGGAACACGG AGCAGGAGGA GGGCGGTGAG GCGGTGCACG 
AGGTGGAGGT GGTCATCAAG CACAACCGGT TCACAAAGGA GACCTATGAC TTCGACATCG 
CCGTGCTCCG GCTCAAGACC CCCATCACCT TCCGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001299604.1
CDS	58..1056
Translation	MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKGTGTRSRRRAVRRCTRWRWSSSTTGSQRRPMTSTSPCSGSRPPSPSA

Target ORF information:

RefSeq Version	NM_001312675.1
Organism	Homo sapiens(human)
Definition	Homo sapiens coagulation factor X (F10), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001312675.1

ORF Insert Sequence:

ATGGGGCGCC CACTGCACCT CGTCCTGCTC AGTGCCTCCC TGGCTGGCCT CCTGCTGCTC 
GGGGAAAGTC TGTTCATCCG CAGGGAGCAG GCCAACAACA TCCTGGCGAG GGTCACGAGG 
GCCAATTCCT TTCTTGAAGA GATGAAGAAA GGACACCTCG AAAGAGAGTG CATGGAAGAG 
ACCTGCTCAT ACGAAGAGGC CCGCGAGGTC TTTGAGGACA GCGACAAGAC GAATGAATTC 
TGGAATAAAT ACAAAGATGG CGACCAGTGT GAGACCAGTC CTTGCCAGAA CCAGGGCAAA 
TGTAAAGACG GCCTCGGGGA ATACACCTGC ACCTGTTTAG AAGGATTCGA AGGCAAAAAC 
TGTGAATTAT TCACACGGAA GCTCTGCAGC CTGGACAACG GGGACTGTGA CCAGTTCTGC 
CACGAGGAAC AGAACTCTGT GGTGTGCTCC TGCGCCCGCG GGTACACCCT GGCTGACAAC 
GGCAAGGCCT GCATTCCCAC AGGGCCCTAC CCCTGTGGGA AACAGACCCT GGAACGCAGG 
AAGAGGTCAG TGGCCCAGGC CACCAGCAGC AGCGGGGAGG CCCCTGACAG CATCACATGG 
AAGCCATATG ATGCAGCCGA CCTGGACCCC ACCGAGAACC CCTTCGACCT GCTTGACTTC 
AACCAGACGC AGCCTGAGAG GGGCGACAAC AACCTCACCA GGATCGTGGG AGGCCAGGAA 
TGCAAGGACG GGGAGTGTCC CTGGCAGGCC CTGCTCATCA ATGAGGAAAA CGAGGGTTTC 
TGTGGTGGAA CCATTCTGAG CGAGTTCTAC ATCCTAACGG CAGCCCACTG TCTCTACCAA 
GCCAAGAGAT TCAAGGGGAC CGGAACACGG AGCAGGAGGA GGGCGGTGAG GCGGTGCACG 
AGGTGGAGGT GGTCATCAAG CACAACCGGT TCACAAAGGA GACCTATGAC TTCGACATCG 
CCGTGCTCCG GCTCAAGACC CCCATCACCT TCCGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

F10 ( NM_001312675.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001299604.1 Homo sapiens coagulation factor X (F10), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu47414
Clone ID Related Accession (Same CDS sequence)	NM_001312675.1 , NM_001312675.2
Accession Version	NM_001312675.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 999bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	coagulation factor X isoform 3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB158437.1, M22613.1 and BC046125.1. On May 31, 2019 this sequence version replaced NM_001312675.1. Transcript Variant: This variant (3) uses an alternate splice site in the penultimate exon, compared to variant 1, resulting in differences in the 3' coding region and 3' UTR. It encodes isoform 3 which has a distinct C-terminus, compared to isoform 1. This isoform (3) may undergo proteolytic processing similar to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M22613.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGGGCGCC CACTGCACCT CGTCCTGCTC AGTGCCTCCC TGGCTGGCCT CCTGCTGCTC 
GGGGAAAGTC TGTTCATCCG CAGGGAGCAG GCCAACAACA TCCTGGCGAG GGTCACGAGG 
GCCAATTCCT TTCTTGAAGA GATGAAGAAA GGACACCTCG AAAGAGAGTG CATGGAAGAG 
ACCTGCTCAT ACGAAGAGGC CCGCGAGGTC TTTGAGGACA GCGACAAGAC GAATGAATTC 
TGGAATAAAT ACAAAGATGG CGACCAGTGT GAGACCAGTC CTTGCCAGAA CCAGGGCAAA 
TGTAAAGACG GCCTCGGGGA ATACACCTGC ACCTGTTTAG AAGGATTCGA AGGCAAAAAC 
TGTGAATTAT TCACACGGAA GCTCTGCAGC CTGGACAACG GGGACTGTGA CCAGTTCTGC 
CACGAGGAAC AGAACTCTGT GGTGTGCTCC TGCGCCCGCG GGTACACCCT GGCTGACAAC 
GGCAAGGCCT GCATTCCCAC AGGGCCCTAC CCCTGTGGGA AACAGACCCT GGAACGCAGG 
AAGAGGTCAG TGGCCCAGGC CACCAGCAGC AGCGGGGAGG CCCCTGACAG CATCACATGG 
AAGCCATATG ATGCAGCCGA CCTGGACCCC ACCGAGAACC CCTTCGACCT GCTTGACTTC 
AACCAGACGC AGCCTGAGAG GGGCGACAAC AACCTCACCA GGATCGTGGG AGGCCAGGAA 
TGCAAGGACG GGGAGTGTCC CTGGCAGGCC CTGCTCATCA ATGAGGAAAA CGAGGGTTTC 
TGTGGTGGAA CCATTCTGAG CGAGTTCTAC ATCCTAACGG CAGCCCACTG TCTCTACCAA 
GCCAAGAGAT TCAAGGGGAC CGGAACACGG AGCAGGAGGA GGGCGGTGAG GCGGTGCACG 
AGGTGGAGGT GGTCATCAAG CACAACCGGT TCACAAAGGA GACCTATGAC TTCGACATCG 
CCGTGCTCCG GCTCAAGACC CCCATCACCT TCCGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001299604.1
CDS	58..1056
Translation	MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKGTGTRSRRRAVRRCTRWRWSSSTTGSQRRPMTSTSPCSGSRPPSPSA

Target ORF information:

RefSeq Version	NM_001312675.2
Organism	Homo sapiens(human)
Definition	Homo sapiens coagulation factor X (F10), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001312675.2

ORF Insert Sequence:

ATGGGGCGCC CACTGCACCT CGTCCTGCTC AGTGCCTCCC TGGCTGGCCT CCTGCTGCTC 
GGGGAAAGTC TGTTCATCCG CAGGGAGCAG GCCAACAACA TCCTGGCGAG GGTCACGAGG 
GCCAATTCCT TTCTTGAAGA GATGAAGAAA GGACACCTCG AAAGAGAGTG CATGGAAGAG 
ACCTGCTCAT ACGAAGAGGC CCGCGAGGTC TTTGAGGACA GCGACAAGAC GAATGAATTC 
TGGAATAAAT ACAAAGATGG CGACCAGTGT GAGACCAGTC CTTGCCAGAA CCAGGGCAAA 
TGTAAAGACG GCCTCGGGGA ATACACCTGC ACCTGTTTAG AAGGATTCGA AGGCAAAAAC 
TGTGAATTAT TCACACGGAA GCTCTGCAGC CTGGACAACG GGGACTGTGA CCAGTTCTGC 
CACGAGGAAC AGAACTCTGT GGTGTGCTCC TGCGCCCGCG GGTACACCCT GGCTGACAAC 
GGCAAGGCCT GCATTCCCAC AGGGCCCTAC CCCTGTGGGA AACAGACCCT GGAACGCAGG 
AAGAGGTCAG TGGCCCAGGC CACCAGCAGC AGCGGGGAGG CCCCTGACAG CATCACATGG 
AAGCCATATG ATGCAGCCGA CCTGGACCCC ACCGAGAACC CCTTCGACCT GCTTGACTTC 
AACCAGACGC AGCCTGAGAG GGGCGACAAC AACCTCACCA GGATCGTGGG AGGCCAGGAA 
TGCAAGGACG GGGAGTGTCC CTGGCAGGCC CTGCTCATCA ATGAGGAAAA CGAGGGTTTC 
TGTGGTGGAA CCATTCTGAG CGAGTTCTAC ATCCTAACGG CAGCCCACTG TCTCTACCAA 
GCCAAGAGAT TCAAGGGGAC CGGAACACGG AGCAGGAGGA GGGCGGTGAG GCGGTGCACG 
AGGTGGAGGT GGTCATCAAG CACAACCGGT TCACAAAGGA GACCTATGAC TTCGACATCG 
CCGTGCTCCG GCTCAAGACC CCCATCACCT TCCGCATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Activities of Thrombin and Factor Xa are essential for replication of Hepatitis E virus and are possibly implicated in the ORF1 polyprotein processing.
Journal of virology(2018 Jan)
Kanade GD,Pingale KD,Karpe YA

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F10 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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