ALAD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ALAD
Entrez Gene ID	210
Full Name	aminolevulinate dehydratase
Synonyms	ALADH,PBGS
General protein information	Preferred Names aminolevulinate dehydratase Names delta-aminolevulinic acid dehydratase aminolevulinate, delta-, dehydratase porphobilinogen synthase testicular tissue protein Li 95
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9q32
Summary	The ALAD enzyme is composed of 8 identical subunits and catalyzes the condensation of 2 molecules of delta-aminolevulinate to form porphobilinogen (a precursor of heme, cytochromes and other hemoproteins). ALAD catalyzes the second step in the porphyrin and heme biosynthetic pathway; zinc is essential for enzymatic activity. ALAD enzymatic activity is inhibited by lead and a defect in the ALAD structural gene can cause increased sensitivity to lead poisoning and acute hepatic porphyria. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
Disorder MIM:	125270
Disorder Html:	Porphyria, acute hepatic, 612740 (3); {Lead poisoning, susceptibility to}, 612740 (3)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011518364.2	XP_011516666.1	delta-aminolevulinic acid dehydratase isoform X2
NM_000031.6	NP_000022.3	delta-aminolevulinic acid dehydratase isoform b
NM_001317745.1	NP_001304674.1	delta-aminolevulinic acid dehydratase isoform c
NM_000031.5	NP_000022.3	delta-aminolevulinic acid dehydratase isoform b
XM_024447449.1	XP_024303217.1	delta-aminolevulinic acid dehydratase isoform X1
NM_001003945.2	NP_001003945.1	delta-aminolevulinic acid dehydratase isoform a

Pathways from BioSystems

Homologies

	ALAD	XP_001101576.1
Danio rerio (zebrafish)	alad	NP_001017645.1
Kluyveromyces lactis	KLLA0F09273g	XP_455502.1
Xenopus tropicalis (tropical clawed frog)	alad	NP_001072186.1
Gallus gallus (chicken)	HDHD3	XP_004945820.1
Drosophila melanogaster (fruit fly)	Pbgs	NP_648564.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010935	XP_309759.4
Magnaporthe oryzae (rice blast fungus)	MGG_10655	XP_003710087.1
Homo sapiens (human)	ALAD	NP_000022.3
Canis lupus familiaris (dog)	ALAD	XP_855370.1
Bos taurus (cattle)	ALAD	NP_001014895.1
Neurospora crassa	NCU01013	XP_961625.1
Pan troglodytes (chimpanzee)	ALAD	XP_001152445.2
Mus musculus (house mouse)	Alad	NP_032551.3
Eremothecium gossypii	AGOS_AGR015C	NP_986680.1
Arabidopsis thaliana (thale cress)	HEMB1	NP_001077800.1
Rattus norvegicus (Norway rat)	Alad	NP_037031.1
Saccharomyces cerevisiae (baker's yeast)	HEM2	NP_011475.1
Schizosaccharomyces pombe (fission yeast)	hem2	NP_593917.1
Oryza sativa (rice)	Os06g0704600	NP_001058510.1

Gene Ontology
Bibliography

Related articles in PubMed

Role of ALAD and VDR genotypes on the association of low blood lead level with serum uric acid and blood pressure in automobile paint workers of Karachi, Pakistan.
Sadaf S, Siddiqui AA, Ansari MA
Pakistan journal of pharmaceutical sciences30(6)2223-2231(2017 Nov)

Downregulation of delta-aminolevulinate dehydratase is associated with poor prognosis in?patients with breast cancer.
Ge J, Yu Y, Xin F, Yang ZJ, Zhao HM, Wang X, Tong ZS, Cao XC
Cancer science108(4)604-611(2017 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Overexpression of delta-aminolevulinate dehydratase (ALAD)suppresses breast cancer cell proliferation and invasion and inhibits the epithelial-mesenchymal transition phenotype.
Title: Downregulation of delta-aminolevulinate dehydratase is associated with poor prognosis in?patients with breast cancer.

Delta-aminolevulinate dehydratase activity and oxidative stress markers were significantly lowered in preeclampsia.
Title: Delta-aminolevulinate dehydratase activity and oxidative stress markers in preeclampsia.

Results show statistically significant association between the maternal ALAD G177C polymorphism and placental lead levels.
Title: Association between delta-aminolevulinic acid dehydratase polymorphism and placental lead levels.

Blood lead level affected ALAD but not GPx activities, and these were not modulated by polymorphisms in ALAD and GPx genes.
Title: Effects of Lead Exposure and Genetic Polymorphisms on ALAD and GPx Activities in Brazilian Battery Workers.

Maternal ALAD gene polymorphism can affect early neonatal neurobehavioral development by influencing the blood lead level.
Title: Relationship among maternal blood lead, ALAD gene polymorphism and neonatal neurobehavioral development.

The following ALAD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ALAD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18534	NM_000031.6 Latest version!	Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu43074	NM_001003945.2 Latest version!	Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu43074	XM_024447449.1 Latest version!	Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu56226	XM_011518364.2 Latest version!	Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu101902	NM_001317745.1 Latest version!	Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu18534	NM_000031.5	Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ALAD ( NM_000031.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_000022.3 Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18534
Clone ID Related Accession (Same CDS sequence)	NM_000031.6 , NM_000031.5
Accession Version	NM_000031.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	delta-aminolevulinic acid dehydratase isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA805310.1, AK290490.1, AK131490.1, BC000977.3 and BU625796.1. This sequence is a reference standard in the RefSeqGene project. On Nov 20, 2018 this sequence version replaced NM_000031.5. Transcript Variant: This variant (2) lacks a segment of the coding region and initiates translation from an alternate start codon, compared to variant 1. The resulting isoform (b) has a distinct N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803617.172413.1, SRR1660805.72089.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: experimental evidence (PMID:12665801) MANE Ensembl match :: ENST00000409155.8/ ENSP00000386284.3 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCAGCCCC AGTCCGTTCT GCACAGCGGC TACTTCCACC CACTACTTCG GGCCTGGCAG 
ACAGCCACCA CCACCCTCAA TGCCTCCAAC CTCATCTACC CCATCTTTGT CACGGATGTT 
CCTGATGACA TACAGCCTAT CACCAGCCTC CCAGGAGTGG CCAGGTATGG TGTGAAGCGG 
CTGGAAGAGA TGCTGAGGCC CTTGGTGGAA GAGGGCCTAC GCTGTGTCTT GATCTTTGGC 
GTCCCCAGCA GAGTTCCCAA GGACGAGCGG GGTTCCGCAG CTGACTCCGA GGAGTCCCCA 
GCTATTGAGG CAATCCATCT GTTGAGGAAG ACCTTCCCCA ACCTCCTGGT GGCCTGTGAT 
GTCTGCCTGT GTCCCTACAC CTCCCATGGT CACTGCGGGC TCCTGAGTGA AAACGGAGCA 
TTCCGGGCTG AGGAGAGCCG CCAGCGGCTG GCTGAGGTGG CATTGGCGTA TGCCAAGGCA 
GGATGTCAGG TGGTAGCCCC GTCGGACATG ATGGATGGAC GCGTGGAAGC CATCAAAGAG 
GCCCTGATGG CACATGGACT TGGCAACAGG GTATCGGTGA TGAGCTACAG TGCCAAATTT 
GCTTCCTGTT TCTATGGCCC TTTCCGGGAT GCAGCTAAGT CAAGCCCAGC TTTTGGGGAC 
CGCCGCTGCT ACCAGCTGCC CCCTGGAGCA CGAGGCCTGG CTCTCCGAGC TGTGGACCGG 
GATGTACGGG AAGGAGCTGA CATGCTCATG GTGAAGCCGG GAATGCCCTA CCTGGACATC 
GTGCGGGAGG TAAAGGACAA GCACCCTGAC CTCCCTCTCG CCGTGTACCA CGTCTCTGGA 
GAGTTTGCCA TGCTGTGGCA TGGAGCCCAG GCCGGGGCAT TTGATCTCAA GGCTGCCGTA 
CTGGAGGCCA TGACTGCCTT CCGCAGAGCA GGTGCTGACA TCATCATCAC CTACTACACA 
CCGCAGCTGC TGCAGTGGCT GAAGGAGGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000022.3
CDS	149..1141
Translation	MQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDIQPITSLPGVARYGVKRLEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE

Target ORF information:

RefSeq Version	NM_000031.6
Organism	Homo sapiens(human)
Definition	Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000031.6

ORF Insert Sequence:

ATGCAGCCCC AGTCCGTTCT GCACAGCGGC TACTTCCACC CACTACTTCG GGCCTGGCAG 
ACAGCCACCA CCACCCTCAA TGCCTCCAAC CTCATCTACC CCATCTTTGT CACGGATGTT 
CCTGATGACA TACAGCCTAT CACCAGCCTC CCAGGAGTGG CCAGGTATGG TGTGAAGCGG 
CTGGAAGAGA TGCTGAGGCC CTTGGTGGAA GAGGGCCTAC GCTGTGTCTT GATCTTTGGC 
GTCCCCAGCA GAGTTCCCAA GGACGAGCGG GGTTCCGCAG CTGACTCCGA GGAGTCCCCA 
GCTATTGAGG CAATCCATCT GTTGAGGAAG ACCTTCCCCA ACCTCCTGGT GGCCTGTGAT 
GTCTGCCTGT GTCCCTACAC CTCCCATGGT CACTGCGGGC TCCTGAGTGA AAACGGAGCA 
TTCCGGGCTG AGGAGAGCCG CCAGCGGCTG GCTGAGGTGG CATTGGCGTA TGCCAAGGCA 
GGATGTCAGG TGGTAGCCCC GTCGGACATG ATGGATGGAC GCGTGGAAGC CATCAAAGAG 
GCCCTGATGG CACATGGACT TGGCAACAGG GTATCGGTGA TGAGCTACAG TGCCAAATTT 
GCTTCCTGTT TCTATGGCCC TTTCCGGGAT GCAGCTAAGT CAAGCCCAGC TTTTGGGGAC 
CGCCGCTGCT ACCAGCTGCC CCCTGGAGCA CGAGGCCTGG CTCTCCGAGC TGTGGACCGG 
GATGTACGGG AAGGAGCTGA CATGCTCATG GTGAAGCCGG GAATGCCCTA CCTGGACATC 
GTGCGGGAGG TAAAGGACAA GCACCCTGAC CTCCCTCTCG CCGTGTACCA CGTCTCTGGA 
GAGTTTGCCA TGCTGTGGCA TGGAGCCCAG GCCGGGGCAT TTGATCTCAA GGCTGCCGTA 
CTGGAGGCCA TGACTGCCTT CCGCAGAGCA GGTGCTGACA TCATCATCAC CTACTACACA 
CCGCAGCTGC TGCAGTGGCT GAAGGAGGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALAD ( NM_000031.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_000022.3 Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu18534
Clone ID Related Accession (Same CDS sequence)	NM_000031.6 , NM_000031.5
Accession Version	NM_000031.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 993bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	delta-aminolevulinic acid dehydratase isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA412142.1, DA805310.1, AK290490.1, AK131490.1, BC000977.3 and BU625796.1. This sequence is a reference standard in the RefSeqGene project. On May 24, 2008 this sequence version replaced NM_000031.4. Transcript Variant: This variant (2) lacks a segment of the coding region and initiates translation from an alternate start codon, compared to variant 1. The resulting isoform (b) has a distinct N-terminus, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005408.1, SRR1803611.255776.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## CDS uses downstream in-frame AUG :: experimental evidence (PMID:12665801) ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCAGCCCC AGTCCGTTCT GCACAGCGGC TACTTCCACC CACTACTTCG GGCCTGGCAG 
ACAGCCACCA CCACCCTCAA TGCCTCCAAC CTCATCTACC CCATCTTTGT CACGGATGTT 
CCTGATGACA TACAGCCTAT CACCAGCCTC CCAGGAGTGG CCAGGTATGG TGTGAAGCGG 
CTGGAAGAGA TGCTGAGGCC CTTGGTGGAA GAGGGCCTAC GCTGTGTCTT GATCTTTGGC 
GTCCCCAGCA GAGTTCCCAA GGACGAGCGG GGTTCCGCAG CTGACTCCGA GGAGTCCCCA 
GCTATTGAGG CAATCCATCT GTTGAGGAAG ACCTTCCCCA ACCTCCTGGT GGCCTGTGAT 
GTCTGCCTGT GTCCCTACAC CTCCCATGGT CACTGCGGGC TCCTGAGTGA AAACGGAGCA 
TTCCGGGCTG AGGAGAGCCG CCAGCGGCTG GCTGAGGTGG CATTGGCGTA TGCCAAGGCA 
GGATGTCAGG TGGTAGCCCC GTCGGACATG ATGGATGGAC GCGTGGAAGC CATCAAAGAG 
GCCCTGATGG CACATGGACT TGGCAACAGG GTATCGGTGA TGAGCTACAG TGCCAAATTT 
GCTTCCTGTT TCTATGGCCC TTTCCGGGAT GCAGCTAAGT CAAGCCCAGC TTTTGGGGAC 
CGCCGCTGCT ACCAGCTGCC CCCTGGAGCA CGAGGCCTGG CTCTCCGAGC TGTGGACCGG 
GATGTACGGG AAGGAGCTGA CATGCTCATG GTGAAGCCGG GAATGCCCTA CCTGGACATC 
GTGCGGGAGG TAAAGGACAA GCACCCTGAC CTCCCTCTCG CCGTGTACCA CGTCTCTGGA 
GAGTTTGCCA TGCTGTGGCA TGGAGCCCAG GCCGGGGCAT TTGATCTCAA GGCTGCCGTA 
CTGGAGGCCA TGACTGCCTT CCGCAGAGCA GGTGCTGACA TCATCATCAC CTACTACACA 
CCGCAGCTGC TGCAGTGGCT GAAGGAGGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_000022.3
CDS	203..1195
Translation	MQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDIQPITSLPGVARYGVKRLEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE

Target ORF information:

RefSeq Version	NM_000031.5
Organism	Homo sapiens(human)
Definition	Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_000031.5

ORF Insert Sequence:

ATGCAGCCCC AGTCCGTTCT GCACAGCGGC TACTTCCACC CACTACTTCG GGCCTGGCAG 
ACAGCCACCA CCACCCTCAA TGCCTCCAAC CTCATCTACC CCATCTTTGT CACGGATGTT 
CCTGATGACA TACAGCCTAT CACCAGCCTC CCAGGAGTGG CCAGGTATGG TGTGAAGCGG 
CTGGAAGAGA TGCTGAGGCC CTTGGTGGAA GAGGGCCTAC GCTGTGTCTT GATCTTTGGC 
GTCCCCAGCA GAGTTCCCAA GGACGAGCGG GGTTCCGCAG CTGACTCCGA GGAGTCCCCA 
GCTATTGAGG CAATCCATCT GTTGAGGAAG ACCTTCCCCA ACCTCCTGGT GGCCTGTGAT 
GTCTGCCTGT GTCCCTACAC CTCCCATGGT CACTGCGGGC TCCTGAGTGA AAACGGAGCA 
TTCCGGGCTG AGGAGAGCCG CCAGCGGCTG GCTGAGGTGG CATTGGCGTA TGCCAAGGCA 
GGATGTCAGG TGGTAGCCCC GTCGGACATG ATGGATGGAC GCGTGGAAGC CATCAAAGAG 
GCCCTGATGG CACATGGACT TGGCAACAGG GTATCGGTGA TGAGCTACAG TGCCAAATTT 
GCTTCCTGTT TCTATGGCCC TTTCCGGGAT GCAGCTAAGT CAAGCCCAGC TTTTGGGGAC 
CGCCGCTGCT ACCAGCTGCC CCCTGGAGCA CGAGGCCTGG CTCTCCGAGC TGTGGACCGG 
GATGTACGGG AAGGAGCTGA CATGCTCATG GTGAAGCCGG GAATGCCCTA CCTGGACATC 
GTGCGGGAGG TAAAGGACAA GCACCCTGAC CTCCCTCTCG CCGTGTACCA CGTCTCTGGA 
GAGTTTGCCA TGCTGTGGCA TGGAGCCCAG GCCGGGGCAT TTGATCTCAA GGCTGCCGTA 
CTGGAGGCCA TGACTGCCTT CCGCAGAGCA GGTGCTGACA TCATCATCAC CTACTACACA 
CCGCAGCTGC TGCAGTGGCT GAAGGAGGAA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALAD ( NM_001003945.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001003945.1 Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu43074
Clone ID Related Accession (Same CDS sequence)	XM_024447449.1 , NM_001003945.2
Accession Version	NM_001003945.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-29
Organism	Homo sapiens(human)
Product	delta-aminolevulinic acid dehydratase isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA412142.1, AK131490.1, AK290490.1 and BU625796.1. On or before Dec 8, 2015 this sequence version replaced XM_005251799.1, NM_001003945.1. Transcript Variant: This variant (1) represents the longest transcript, and encodes the longest isoform (a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK131490.1, SRR1803615.47426.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCTCCAA CCTCATCTAC CCCATCTTTG TCACGCCCTG GGCTTGGCCA GGCAGGGAAG 
CCAGACACTG GATCCCATCC TCCTCCCACC ATCTCCACTT CCATATTTCT TTCCTGCTTC 
CCAACCATCC CTCTCAGTCG CCCCCGCACC ACTGGCCCTT CCCACAGCTA CCAATCCATA 
TCCCACCCCC GCTCTTGCAG GGATGTTCCT GATGACATAC AGCCTATCAC CAGCCTCCCA 
GGAGTGGCCA GGTATGGTGT GAAGCGGCTG GAAGAGATGC TGAGGCCCTT GGTGGAAGAG 
GGCCTACGCT GTGTCTTGAT CTTTGGCGTC CCCAGCAGAG TTCCCAAGGA CGAGCGGGGT 
TCCGCAGCTG ACTCCGAGGA GTCCCCAGCT ATTGAGGCAA TCCATCTGTT GAGGAAGACC 
TTCCCCAACC TCCTGGTGGC CTGTGATGTC TGCCTGTGTC CCTACACCTC CCATGGTCAC 
TGCGGGCTCC TGAGTGAAAA CGGAGCATTC CGGGCTGAGG AGAGCCGCCA GCGGCTGGCT 
GAGGTGGCAT TGGCGTATGC CAAGGCAGGA TGTCAGGTGG TAGCCCCGTC GGACATGATG 
GATGGACGCG TGGAAGCCAT CAAAGAGGCC CTGATGGCAC ATGGACTTGG CAACAGGGTA 
TCGGTGATGA GCTACAGTGC CAAATTTGCT TCCTGTTTCT ATGGCCCTTT CCGGGATGCA 
GCTAAGTCAA GCCCAGCTTT TGGGGACCGC CGCTGCTACC AGCTGCCCCC TGGAGCACGA 
GGCCTGGCTC TCCGAGCTGT GGACCGGGAT GTACGGGAAG GAGCTGACAT GCTCATGGTG 
AAGCCGGGAA TGCCCTACCT GGACATCGTG CGGGAGGTAA AGGACAAGCA CCCTGACCTC 
CCTCTCGCCG TGTACCACGT CTCTGGAGAG TTTGCCATGC TGTGGCATGG AGCCCAGGCC 
GGGGCATTTG ATCTCAAGGC TGCCGTACTG GAGGCCATGA CTGCCTTCCG CAGAGCAGGT 
GCTGACATCA TCATCACCTA CTACACACCG CAGCTGCTGC AGTGGCTGAA GGAGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001003945.1
CDS	282..1361
Translation	MPPTSSTPSLSRPGLGQAGKPDTGSHPPPTISTSIFLSCFPTIPLSRPRTTGPSHSYQSISHPRSCRDVPDDIQPITSLPGVARYGVKRLEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE

Target ORF information:

RefSeq Version	NM_001003945.2
Organism	Homo sapiens(human)
Definition	Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001003945.2

ORF Insert Sequence:

ATGCCTCCAA CCTCATCTAC CCCATCTTTG TCACGCCCTG GGCTTGGCCA GGCAGGGAAG 
CCAGACACTG GATCCCATCC TCCTCCCACC ATCTCCACTT CCATATTTCT TTCCTGCTTC 
CCAACCATCC CTCTCAGTCG CCCCCGCACC ACTGGCCCTT CCCACAGCTA CCAATCCATA 
TCCCACCCCC GCTCTTGCAG GGATGTTCCT GATGACATAC AGCCTATCAC CAGCCTCCCA 
GGAGTGGCCA GGTATGGTGT GAAGCGGCTG GAAGAGATGC TGAGGCCCTT GGTGGAAGAG 
GGCCTACGCT GTGTCTTGAT CTTTGGCGTC CCCAGCAGAG TTCCCAAGGA CGAGCGGGGT 
TCCGCAGCTG ACTCCGAGGA GTCCCCAGCT ATTGAGGCAA TCCATCTGTT GAGGAAGACC 
TTCCCCAACC TCCTGGTGGC CTGTGATGTC TGCCTGTGTC CCTACACCTC CCATGGTCAC 
TGCGGGCTCC TGAGTGAAAA CGGAGCATTC CGGGCTGAGG AGAGCCGCCA GCGGCTGGCT 
GAGGTGGCAT TGGCGTATGC CAAGGCAGGA TGTCAGGTGG TAGCCCCGTC GGACATGATG 
GATGGACGCG TGGAAGCCAT CAAAGAGGCC CTGATGGCAC ATGGACTTGG CAACAGGGTA 
TCGGTGATGA GCTACAGTGC CAAATTTGCT TCCTGTTTCT ATGGCCCTTT CCGGGATGCA 
GCTAAGTCAA GCCCAGCTTT TGGGGACCGC CGCTGCTACC AGCTGCCCCC TGGAGCACGA 
GGCCTGGCTC TCCGAGCTGT GGACCGGGAT GTACGGGAAG GAGCTGACAT GCTCATGGTG 
AAGCCGGGAA TGCCCTACCT GGACATCGTG CGGGAGGTAA AGGACAAGCA CCCTGACCTC 
CCTCTCGCCG TGTACCACGT CTCTGGAGAG TTTGCCATGC TGTGGCATGG AGCCCAGGCC 
GGGGCATTTG ATCTCAAGGC TGCCGTACTG GAGGCCATGA CTGCCTTCCG CAGAGCAGGT 
GCTGACATCA TCATCACCTA CTACACACCG CAGCTGCTGC AGTGGCTGAA GGAGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALAD ( XM_024447449.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_024303217.1 Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant X1, mRNA.

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CloneID	OHu43074
Clone ID Related Accession (Same CDS sequence)	XM_024447449.1 , NM_001003945.2
Accession Version	XM_024447449.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1080bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	delta-aminolevulinic acid dehydratase isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCTCCAA CCTCATCTAC CCCATCTTTG TCACGCCCTG GGCTTGGCCA GGCAGGGAAG 
CCAGACACTG GATCCCATCC TCCTCCCACC ATCTCCACTT CCATATTTCT TTCCTGCTTC 
CCAACCATCC CTCTCAGTCG CCCCCGCACC ACTGGCCCTT CCCACAGCTA CCAATCCATA 
TCCCACCCCC GCTCTTGCAG GGATGTTCCT GATGACATAC AGCCTATCAC CAGCCTCCCA 
GGAGTGGCCA GGTATGGTGT GAAGCGGCTG GAAGAGATGC TGAGGCCCTT GGTGGAAGAG 
GGCCTACGCT GTGTCTTGAT CTTTGGCGTC CCCAGCAGAG TTCCCAAGGA CGAGCGGGGT 
TCCGCAGCTG ACTCCGAGGA GTCCCCAGCT ATTGAGGCAA TCCATCTGTT GAGGAAGACC 
TTCCCCAACC TCCTGGTGGC CTGTGATGTC TGCCTGTGTC CCTACACCTC CCATGGTCAC 
TGCGGGCTCC TGAGTGAAAA CGGAGCATTC CGGGCTGAGG AGAGCCGCCA GCGGCTGGCT 
GAGGTGGCAT TGGCGTATGC CAAGGCAGGA TGTCAGGTGG TAGCCCCGTC GGACATGATG 
GATGGACGCG TGGAAGCCAT CAAAGAGGCC CTGATGGCAC ATGGACTTGG CAACAGGGTA 
TCGGTGATGA GCTACAGTGC CAAATTTGCT TCCTGTTTCT ATGGCCCTTT CCGGGATGCA 
GCTAAGTCAA GCCCAGCTTT TGGGGACCGC CGCTGCTACC AGCTGCCCCC TGGAGCACGA 
GGCCTGGCTC TCCGAGCTGT GGACCGGGAT GTACGGGAAG GAGCTGACAT GCTCATGGTG 
AAGCCGGGAA TGCCCTACCT GGACATCGTG CGGGAGGTAA AGGACAAGCA CCCTGACCTC 
CCTCTCGCCG TGTACCACGT CTCTGGAGAG TTTGCCATGC TGTGGCATGG AGCCCAGGCC 
GGGGCATTTG ATCTCAAGGC TGCCGTACTG GAGGCCATGA CTGCCTTCCG CAGAGCAGGT 
GCTGACATCA TCATCACCTA CTACACACCG CAGCTGCTGC AGTGGCTGAA GGAGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_024303217.1
CDS	384..1463
Translation	MPPTSSTPSLSRPGLGQAGKPDTGSHPPPTISTSIFLSCFPTIPLSRPRTTGPSHSYQSISHPRSCRDVPDDIQPITSLPGVARYGVKRLEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE

Target ORF information:

RefSeq Version	XM_024447449.1
Organism	Homo sapiens(human)
Definition	Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_024447449.1

ORF Insert Sequence:

ATGCCTCCAA CCTCATCTAC CCCATCTTTG TCACGCCCTG GGCTTGGCCA GGCAGGGAAG 
CCAGACACTG GATCCCATCC TCCTCCCACC ATCTCCACTT CCATATTTCT TTCCTGCTTC 
CCAACCATCC CTCTCAGTCG CCCCCGCACC ACTGGCCCTT CCCACAGCTA CCAATCCATA 
TCCCACCCCC GCTCTTGCAG GGATGTTCCT GATGACATAC AGCCTATCAC CAGCCTCCCA 
GGAGTGGCCA GGTATGGTGT GAAGCGGCTG GAAGAGATGC TGAGGCCCTT GGTGGAAGAG 
GGCCTACGCT GTGTCTTGAT CTTTGGCGTC CCCAGCAGAG TTCCCAAGGA CGAGCGGGGT 
TCCGCAGCTG ACTCCGAGGA GTCCCCAGCT ATTGAGGCAA TCCATCTGTT GAGGAAGACC 
TTCCCCAACC TCCTGGTGGC CTGTGATGTC TGCCTGTGTC CCTACACCTC CCATGGTCAC 
TGCGGGCTCC TGAGTGAAAA CGGAGCATTC CGGGCTGAGG AGAGCCGCCA GCGGCTGGCT 
GAGGTGGCAT TGGCGTATGC CAAGGCAGGA TGTCAGGTGG TAGCCCCGTC GGACATGATG 
GATGGACGCG TGGAAGCCAT CAAAGAGGCC CTGATGGCAC ATGGACTTGG CAACAGGGTA 
TCGGTGATGA GCTACAGTGC CAAATTTGCT TCCTGTTTCT ATGGCCCTTT CCGGGATGCA 
GCTAAGTCAA GCCCAGCTTT TGGGGACCGC CGCTGCTACC AGCTGCCCCC TGGAGCACGA 
GGCCTGGCTC TCCGAGCTGT GGACCGGGAT GTACGGGAAG GAGCTGACAT GCTCATGGTG 
AAGCCGGGAA TGCCCTACCT GGACATCGTG CGGGAGGTAA AGGACAAGCA CCCTGACCTC 
CCTCTCGCCG TGTACCACGT CTCTGGAGAG TTTGCCATGC TGTGGCATGG AGCCCAGGCC 
GGGGCATTTG ATCTCAAGGC TGCCGTACTG GAGGCCATGA CTGCCTTCCG CAGAGCAGGT 
GCTGACATCA TCATCACCTA CTACACACCG CAGCTGCTGC AGTGGCTGAA GGAGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALAD ( XM_011518364.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011516666.1 Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant X2, mRNA.

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CloneID	OHu56226
Clone ID Related Accession (Same CDS sequence)	XM_011518364.2
Accession Version	XM_011518364.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1020bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	delta-aminolevulinic acid dehydratase isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000009.12) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011518364.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCCCCTGT GCCCACTGGC CCACGCCATG CAGCCCCAGT CCGTTCTGCA CAGCGGCTAC 
TTCCACCCAC TACTTCGGGC CTGGCAGACA GCCACCACCA CCCTCAATGC CTCCAACCTC 
ATCTACCCCA TCTTTGTCAC GGATGTTCCT GATGACATAC AGCCTATCAC CAGCCTCCCA 
GGAGTGGCCA GGTATGGTGT GAAGCGGCTG GAAGAGATGC TGAGGCCCTT GGTGGAAGAG 
GGCCTACGCT GTGTCTTGAT CTTTGGCGTC CCCAGCAGAG TTCCCAAGGA CGAGCGGGGT 
TCCGCAGCTG ACTCCGAGGA GTCCCCAGCT ATTGAGGCAA TCCATCTGTT GAGGAAGACC 
TTCCCCAACC TCCTGGTGGC CTGTGATGTC TGCCTGTGTC CCTACACCTC CCATGGTCAC 
TGCGGGCTCC TGAGTGAAAA CGGAGCATTC CGGGCTGAGG AGAGCCGCCA GCGGCTGGCT 
GAGGTGGCAT TGGCGTATGC CAAGGCAGGA TGTCAGGTGG TAGCCCCGTC GGACATGATG 
GATGGACGCG TGGAAGCCAT CAAAGAGGCC CTGATGGCAC ATGGACTTGG CAACAGGGTA 
TCGGTGATGA GCTACAGTGC CAAATTTGCT TCCTGTTTCT ATGGCCCTTT CCGGGATGCA 
GCTAAGTCAA GCCCAGCTTT TGGGGACCGC CGCTGCTACC AGCTGCCCCC TGGAGCACGA 
GGCCTGGCTC TCCGAGCTGT GGACCGGGAT GTACGGGAAG GAGCTGACAT GCTCATGGTG 
AAGCCGGGAA TGCCCTACCT GGACATCGTG CGGGAGGTAA AGGACAAGCA CCCTGACCTC 
CCTCTCGCCG TGTACCACGT CTCTGGAGAG TTTGCCATGC TGTGGCATGG AGCCCAGGCC 
GGGGCATTTG ATCTCAAGGC TGCCGTACTG GAGGCCATGA CTGCCTTCCG CAGAGCAGGT 
GCTGACATCA TCATCACCTA CTACACACCG CAGCTGCTGC AGTGGCTGAA GGAGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011516666.1
CDS	368..1387
Translation	MPLCPLAHAMQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTDVPDDIQPITSLPGVARYGVKRLEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE

Target ORF information:

RefSeq Version	XM_011518364.2
Organism	Homo sapiens(human)
Definition	Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011518364.2

ORF Insert Sequence:

ATGCCCCTGT GCCCACTGGC CCACGCCATG CAGCCCCAGT CCGTTCTGCA CAGCGGCTAC 
TTCCACCCAC TACTTCGGGC CTGGCAGACA GCCACCACCA CCCTCAATGC CTCCAACCTC 
ATCTACCCCA TCTTTGTCAC GGATGTTCCT GATGACATAC AGCCTATCAC CAGCCTCCCA 
GGAGTGGCCA GGTATGGTGT GAAGCGGCTG GAAGAGATGC TGAGGCCCTT GGTGGAAGAG 
GGCCTACGCT GTGTCTTGAT CTTTGGCGTC CCCAGCAGAG TTCCCAAGGA CGAGCGGGGT 
TCCGCAGCTG ACTCCGAGGA GTCCCCAGCT ATTGAGGCAA TCCATCTGTT GAGGAAGACC 
TTCCCCAACC TCCTGGTGGC CTGTGATGTC TGCCTGTGTC CCTACACCTC CCATGGTCAC 
TGCGGGCTCC TGAGTGAAAA CGGAGCATTC CGGGCTGAGG AGAGCCGCCA GCGGCTGGCT 
GAGGTGGCAT TGGCGTATGC CAAGGCAGGA TGTCAGGTGG TAGCCCCGTC GGACATGATG 
GATGGACGCG TGGAAGCCAT CAAAGAGGCC CTGATGGCAC ATGGACTTGG CAACAGGGTA 
TCGGTGATGA GCTACAGTGC CAAATTTGCT TCCTGTTTCT ATGGCCCTTT CCGGGATGCA 
GCTAAGTCAA GCCCAGCTTT TGGGGACCGC CGCTGCTACC AGCTGCCCCC TGGAGCACGA 
GGCCTGGCTC TCCGAGCTGT GGACCGGGAT GTACGGGAAG GAGCTGACAT GCTCATGGTG 
AAGCCGGGAA TGCCCTACCT GGACATCGTG CGGGAGGTAA AGGACAAGCA CCCTGACCTC 
CCTCTCGCCG TGTACCACGT CTCTGGAGAG TTTGCCATGC TGTGGCATGG AGCCCAGGCC 
GGGGCATTTG ATCTCAAGGC TGCCGTACTG GAGGCCATGA CTGCCTTCCG CAGAGCAGGT 
GCTGACATCA TCATCACCTA CTACACACCG CAGCTGCTGC AGTGGCTGAA GGAGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ALAD ( NM_001317745.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304674.1 Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant 3, mRNA.

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CloneID	OHu101902
Clone ID Related Accession (Same CDS sequence)	NM_001317745.1
Accession Version	NM_001317745.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 969bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-28
Organism	Homo sapiens(human)
Product	delta-aminolevulinic acid dehydratase isoform c
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK295945.1, AK131490.1 and BU625796.1. Transcript Variant: This variant (3) differs in the 5' UTR, lacks an alternate in-frame exon in the 5' coding region and initiates translation from an alternate start codon, compared to variant 1. The resulting isoform (c) has a distinct N-terminus compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK295945.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCCCCTGT GCCCACTGGC CCACGCCATG CAGCCCCAGT CCGTTCTGCA CAGCGGCTAC 
TTCCACCCAC TACTTCGGGC CTGGCAGACA GCCACCACCA CCCTCAATGC CTCCAACCTC 
ATCTACCCCA TCTTTGTCAC GTATGGTGTG AAGCGGCTGG AAGAGATGCT GAGGCCCTTG 
GTGGAAGAGG GCCTACGCTG TGTCTTGATC TTTGGCGTCC CCAGCAGAGT TCCCAAGGAC 
GAGCGGGGTT CCGCAGCTGA CTCCGAGGAG TCCCCAGCTA TTGAGGCAAT CCATCTGTTG 
AGGAAGACCT TCCCCAACCT CCTGGTGGCC TGTGATGTCT GCCTGTGTCC CTACACCTCC 
CATGGTCACT GCGGGCTCCT GAGTGAAAAC GGAGCATTCC GGGCTGAGGA GAGCCGCCAG 
CGGCTGGCTG AGGTGGCATT GGCGTATGCC AAGGCAGGAT GTCAGGTGGT AGCCCCGTCG 
GACATGATGG ATGGACGCGT GGAAGCCATC AAAGAGGCCC TGATGGCACA TGGACTTGGC 
AACAGGGTAT CGGTGATGAG CTACAGTGCC AAATTTGCTT CCTGTTTCTA TGGCCCTTTC 
CGGGATGCAG CTAAGTCAAG CCCAGCTTTT GGGGACCGCC GCTGCTACCA GCTGCCCCCT 
GGAGCACGAG GCCTGGCTCT CCGAGCTGTG GACCGGGATG TACGGGAAGG AGCTGACATG 
CTCATGGTGA AGCCGGGAAT GCCCTACCTG GACATCGTGC GGGAGGTAAA GGACAAGCAC 
CCTGACCTCC CTCTCGCCGT GTACCACGTC TCTGGAGAGT TTGCCATGCT GTGGCATGGA 
GCCCAGGCCG GGGCATTTGA TCTCAAGGCT GCCGTACTGG AGGCCATGAC TGCCTTCCGC 
AGAGCAGGTG CTGACATCAT CATCACCTAC TACACACCGC AGCTGCTGCA GTGGCTGAAG 
GAGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304674.1
CDS	236..1204
Translation	MPLCPLAHAMQPQSVLHSGYFHPLLRAWQTATTTLNASNLIYPIFVTYGVKRLEEMLRPLVEEGLRCVLIFGVPSRVPKDERGSAADSEESPAIEAIHLLRKTFPNLLVACDVCLCPYTSHGHCGLLSENGAFRAEESRQRLAEVALAYAKAGCQVVAPSDMMDGRVEAIKEALMAHGLGNRVSVMSYSAKFASCFYGPFRDAAKSSPAFGDRRCYQLPPGARGLALRAVDRDVREGADMLMVKPGMPYLDIVREVKDKHPDLPLAVYHVSGEFAMLWHGAQAGAFDLKAAVLEAMTAFRRAGADIIITYYTPQLLQWLKEE

Target ORF information:

RefSeq Version	NM_001317745.1
Organism	Homo sapiens(human)
Definition	Homo sapiens aminolevulinate dehydratase (ALAD), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317745.1

ORF Insert Sequence:

ATGCCCCTGT GCCCACTGGC CCACGCCATG CAGCCCCAGT CCGTTCTGCA CAGCGGCTAC 
TTCCACCCAC TACTTCGGGC CTGGCAGACA GCCACCACCA CCCTCAATGC CTCCAACCTC 
ATCTACCCCA TCTTTGTCAC GTATGGTGTG AAGCGGCTGG AAGAGATGCT GAGGCCCTTG 
GTGGAAGAGG GCCTACGCTG TGTCTTGATC TTTGGCGTCC CCAGCAGAGT TCCCAAGGAC 
GAGCGGGGTT CCGCAGCTGA CTCCGAGGAG TCCCCAGCTA TTGAGGCAAT CCATCTGTTG 
AGGAAGACCT TCCCCAACCT CCTGGTGGCC TGTGATGTCT GCCTGTGTCC CTACACCTCC 
CATGGTCACT GCGGGCTCCT GAGTGAAAAC GGAGCATTCC GGGCTGAGGA GAGCCGCCAG 
CGGCTGGCTG AGGTGGCATT GGCGTATGCC AAGGCAGGAT GTCAGGTGGT AGCCCCGTCG 
GACATGATGG ATGGACGCGT GGAAGCCATC AAAGAGGCCC TGATGGCACA TGGACTTGGC 
AACAGGGTAT CGGTGATGAG CTACAGTGCC AAATTTGCTT CCTGTTTCTA TGGCCCTTTC 
CGGGATGCAG CTAAGTCAAG CCCAGCTTTT GGGGACCGCC GCTGCTACCA GCTGCCCCCT 
GGAGCACGAG GCCTGGCTCT CCGAGCTGTG GACCGGGATG TACGGGAAGG AGCTGACATG 
CTCATGGTGA AGCCGGGAAT GCCCTACCTG GACATCGTGC GGGAGGTAAA GGACAAGCAC 
CCTGACCTCC CTCTCGCCGT GTACCACGTC TCTGGAGAGT TTGCCATGCT GTGGCATGGA 
GCCCAGGCCG GGGCATTTGA TCTCAAGGCT GCCGTACTGG AGGCCATGAC TGCCTTCCGC 
AGAGCAGGTG CTGACATCAT CATCACCTAC TACACACCGC AGCTGCTGCA GTGGCTGAAG 
GAGGAATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Role of ALAD and VDR genotypes on the association of low blood lead level with serum uric acid and blood pressure in automobile paint workers of Karachi, Pakistan.
Pakistan journal of pharmaceutical sciences30(6)2223-2231(2017 Nov)
Sadaf S,Siddiqui AA,Ansari MA

Downregulation of delta-aminolevulinate dehydratase is associated with poor prognosis in?patients with breast cancer.
Cancer science108(4)604-611(2017 Apr)
Ge J,Yu Y,Xin F,Yang ZJ,Zhao HM,Wang X,Tong ZS,Cao XC

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ALAD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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