ABCA3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	ABCA3
Entrez Gene ID	21
Full Name	ATP binding cassette subfamily A member 3
Synonyms	ABC-C,ABC3,EST111653,LBM180,SMDP3
General protein information	Preferred Names ATP binding cassette subfamily A member 3 Names ATP-binding cassette sub-family A member 3 ABC transporter 3 ABC-C transporter ATP-binding cassette transporter 3 ATP-binding cassette, sub-family A (ABC1), member 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Summary	The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. The full transporter encoded by this gene may be involved in development of resistance to xenobiotics and engulfment during programmed cell death. [provided by RefSeq, Jul 2008].
Disorder MIM:	601615
Disorder Html:	Surfactant metabolism dysfunction, pulmonary, 3, 610921 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001089.2	NP_001080.2	ATP-binding cassette sub-family A member 3
NM_001089.3	NP_001080.2	ATP-binding cassette sub-family A member 3

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	ABCA3	XP_004945493.1
Xenopus tropicalis (tropical clawed frog)	abca3	XP_002932496.2
Homo sapiens (human)	ABCA3	NP_001080.2
Danio rerio (zebrafish)	abca3b	XP_002661144.3
Mus musculus (house mouse)	Abca3	NP_001034670.1
Rattus norvegicus (Norway rat)	Abca3	XP_006246102.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006380	XP_001688862.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012156	XP_552044.3
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP007504	XP_308371.4
Pan troglodytes (chimpanzee)	ABCA3	XP_510744.2
Canis lupus familiaris (dog)	ABCA3	XP_005621743.1
Bos taurus (cattle)	ABCA3	NP_001107218.1
Drosophila melanogaster (fruit fly)	CG1718	NP_001259764.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012155	XP_320377.4
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP006379	XP_557048.3
Caenorhabditis elegans (roundworm)	abt-4	NP_503175.1

Gene Ontology
Bibliography

Related articles in PubMed

Functional rescue of misfolding ABCA3 mutations by small molecular correctors.
Kinting S, H?ppner S, Schindlbeck U, Forstner ME, Harfst J, Wittmann T, Griese M
Human molecular genetics(2018 Jan)

Surfactant proteins gene variants in premature newborn infants with severe respiratory distress syndrome.
Somaschini M, Presi S, Ferrari M, Vergani B, Carrera P
Journal of perinatology : official journal of the California Perinatal Association(2017 Dec)

Quantification of volume and lipid filling of intracellular vesicles carrying the ABCA3 transporter.
H?ppner S, Kinting S, Torrano AA, Schindlbeck U, Br?uchle C, Zarbock R, Wittmann T, Griese M
Biochimica et biophysica acta1864(12)2330-2335(2017 12)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Genes ABCC7, A3, A8, A12, and C8 prevailed among the most upregulated or downregulated ones. In conclusion, the results supported our theory about general adenosine triphosphate-binding cassette gene expression profiles and their importance for cancer on clinical as well as research levels.
Title: ABC gene expression profiles have clinical importance and possibly form a new hallmark of cancer.

1153 patients with diffuse parenchymal lung disease (DPLD) were registered in the KLR. The DNA of 242 of these patients was sequenced for ABCA3 mutations. 69 patients had at least one variation in the ABCA3 gene. Of 40 patients with two disease-causing ABCA3 mutations, 22 patients were homozygous and 18 heterozygous.
Title: Lung disease caused by

Understanding the relationship between cholesterol and inflammation in the lung, and the role that ABC transporters play in this may illuminate new pathways to target for the treatment of inflammatory lung diseases
Title: Examining the role of ABC lipid transporters in pulmonary lipid homeostasis and inflammation.

two ABCA3 mutations (p.R288K and p.R1474W) identified among term and late-preterm infants with respiratory distress syndrome, were characterized.
Title: Functional Characterization of ATP-Binding Cassette Transporter A3 Mutations from Infants with Respiratory Distress Syndrome.

transporter oligomerization is crucial for ABCA3 function.
Title: Homooligomerization of ABCA3 and its functional significance.

The following ABCA3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the ABCA3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu24147	NM_001089.2 Latest version!	Homo sapiens ATP binding cassette subfamily A member 3 (ABCA3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$659.50-$923.30 $1319.00
OHu107214	NM_001089.3 Latest version!	Homo sapiens ATP binding cassette subfamily A member 3 (ABCA3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	24-26	$951.30 $1359.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

ABCA3 ( NM_001089.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001080.2 Homo sapiens ATP binding cassette subfamily A member 3 (ABCA3), mRNA.

Price & Availability↑

CloneID	OHu24147
Clone ID Related Accession (Same CDS sequence)	NM_001089.2
Accession Version	NM_001089.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5115bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-26
Organism	Homo sapiens(human)
Product	ATP-binding cassette sub-family A member 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC106820.4, DA109409.1, U78735.1, BC020724.1, AB210044.1 and BP397501.1. This sequence is a reference standard in the RefSeqGene project. On Oct 26, 2006 this sequence version replaced NM_001089.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.170505.1, SRR1803617.233010.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTGTGC TCAGGCAGCT GGCGCTCCTC CTCTGGAAGA ACTACACCCT GCAGAAGCGG 
AAGGTCCTGG TGACGGTCCT GGAACTCTTC CTGCCATTGC TGTTTTCTGG GATCCTCATC 
TGGCTCCGCT TGAAGATTCA GTCGGAAAAT GTGCCCAACG CCACCATCTA CCCGGGCCAG 
TCCATCCAGG AGCTGCCTCT GTTCTTCACC TTCCCTCCGC CAGGAGACAC CTGGGAGCTT 
GCCTACATCC CTTCTCACAG TGACGCTGCC AAGACCGTCA CTGAGACAGT GCGCAGGGCA 
CTTGTGATCA ACATGCGAGT GCGCGGCTTT CCCTCCGAGA AGGACTTTGA GGACTACATT 
AGGTACGACA ACTGCTCGTC CAGCGTGCTG GCCGCCGTGG TCTTCGAGCA CCCCTTCAAC 
CACAGCAAGG AGCCCCTGCC GCTGGCGGTG AAATATCACC TACGGTTCAG TTACACACGG 
AGAAATTACA TGTGGACCCA AACAGGCTCC TTTTTCCTGA AAGAGACAGA AGGCTGGCAC 
ACTACTTCCC TTTTCCCGCT TTTCCCAAAC CCAGGACCAA GGGAACCTAC ATCCCCTGAT 
GGCGGAGAAC CTGGGTACAT CCGGGAAGGC TTCCTGGCCG TGCAGCATGC TGTGGACCGG 
GCCATCATGG AGTACCATGC CGATGCCGCC ACACGCCAGC TGTTCCAGAG ACTGACGGTG 
ACCATCAAGA GGTTCCCGTA CCCGCCGTTC ATCGCAGACC CCTTCCTCGT GGCCATCCAG 
TACCAGCTGC CCCTGCTGCT GCTGCTCAGC TTCACCTACA CCGCGCTCAC CATTGCCCGT 
GCTGTCGTGC AGGAGAAGGA AAGGAGGCTG AAGGAGTACA TGCGCATGAT GGGGCTCAGC 
AGCTGGCTGC ACTGGAGTGC CTGGTTCCTC TTGTTCTTCC TCTTCCTCCT CATCGCCGCC 
TCCTTCATGA CCCTGCTCTT CTGTGTCAAG GTGAAGCCAA ATGTAGCCGT GCTGTCCCGC 
AGCGACCCCT CCCTGGTGCT CGCCTTCCTG CTGTGCTTCG CCATCTCTAC CATCTCCTTC 
AGCTTCATGG TCAGCACCTT CTTCAGCAAA GCCAACATGG CAGCAGCCTT CGGAGGCTTC 
CTCTACTTCT TCACCTACAT CCCCTACTTC TTCGTGGCCC CTCGGTACAA CTGGATGACT 
CTGAGCCAGA AGCTCTGCTC CTGCCTCCTG TCTAATGTCG CCATGGCAAT GGGAGCCCAG 
CTCATTGGGA AATTTGAGGC GAAAGGCATG GGCATCCAGT GGCGAGACCT CCTGAGTCCC 
GTCAACGTGG ACGACGACTT CTGCTTCGGG CAGGTGCTGG GGATGCTGCT GCTGGACTCT 
GTGCTCTATG GCCTGGTGAC CTGGTACATG GAGGCCGTCT TCCCAGGGCA GTTCGGCGTG 
CCTCAGCCCT GGTACTTCTT CATCATGCCC TCCTATTGGT GTGGGAAGCC AAGGGCGGTT 
GCAGGGAAGG AGGAAGAAGA CAGTGACCCC GAGAAAGCAC TCAGAAACGA GTACTTTGAA 
GCCGAGCCAG AGGACCTGGT GGCGGGGATC AAGATCAAGC ACCTGTCCAA GGTGTTCAGG 
GTGGGAAATA AGGACAGGGC GGCCGTCAGA GACCTGAACC TCAACCTGTA CGAGGGACAG 
ATCACCGTCC TGCTGGGCCA CAACGGTGCC GGGAAGACCA CCACCCTCTC CATGCTCACA 
GGTCTCTTTC CCCCCACCAG TGGACGGGCA TACATCAGCG GGTATGAAAT TTCCCAGGAC 
ATGGTTCAGA TCCGGAAGAG CCTGGGCCTG TGCCCGCAGC ACGACATCCT GTTTGACAAC 
TTGACAGTCG CAGAGCACCT TTATTTCTAC GCCCAGCTGA AGGGCCTGTC ACGTCAGAAG 
TGCCCTGAAG AAGTCAAGCA GATGCTGCAC ATCATCGGCC TGGAGGACAA GTGGAACTCA 
CGGAGCCGCT TCCTGAGCGG GGGCATGAGG CGCAAGCTCT CCATCGGCAT CGCCCTCATC 
GCAGGCTCCA AGGTGCTGAT ACTGGACGAG CCCACCTCGG GCATGGACGC CATCTCCAGG 
AGGGCCATCT GGGATCTTCT TCAGCGGCAG AAAAGTGACC GCACCATCGT GCTGACCACC 
CACTTCATGG ACGAGGCTGA CCTGCTGGGA GACCGCATCG CCATCATGGC CAAGGGGGAG 
CTGCAGTGCT GCGGGTCCTC GCTGTTCCTC AAGCAGAAAT ACGGTGCCGG CTATCACATG 
ACGCTGGTGA AGGAGCCGCA CTGCAACCCG GAAGACATCT CCCAGCTGGT CCACCACCAC 
GTGCCCAACG CCACGCTGGA GAGCAGCGCT GGGGCCGAGC TGTCTTTCAT CCTTCCCAGA 
GAGAGCACGC ACAGGTTTGA AGGTCTCTTT GCTAAACTGG AGAAGAAGCA GAAAGAGCTG 
GGCATTGCCA GCTTTGGGGC ATCCATCACC ACCATGGAGG AAGTCTTCCT TCGGGTCGGG 
AAGCTGGTGG ACAGCAGTAT GGACATCCAG GCCATCCAGC TCCCTGCCCT GCAGTACCAG 
CACGAGAGGC GCGCCAGCGA CTGGGCTGTG GACAGCAACC TCTGTGGGGC CATGGACCCC 
TCCGACGGCA TTGGAGCCCT CATCGAGGAG GAGCGCACCG CTGTCAAGCT CAACACTGGG 
CTCGCCCTGC ACTGCCAGCA ATTCTGGGCC ATGTTCCTGA AGAAGGCCGC ATACAGCTGG 
CGCGAGTGGA AAATGGTGGC GGCACAGGTC CTGGTGCCTC TGACCTGCGT CACCCTGGCC 
CTCCTGGCCA TCAACTACTC CTCGGAGCTC TTCGACGACC CCATGCTGAG GCTGACCTTG 
GGCGAGTACG GCAGAACCGT CGTGCCCTTC TCAGTTCCCG GGACCTCCCA GCTGGGTCAG 
CAGCTGTCAG AGCATCTGAA AGACGCACTG CAGGCTGAGG GACAGGAGCC CCGCGAGGTG 
CTCGGTGACC TGGAGGAGTT CTTGATCTTC AGGGCTTCTG TGGAGGGGGG CGGCTTTAAT 
GAGCGGTGCC TTGTGGCAGC GTCCTTCAGA GATGTGGGAG AGCGCACGGT CGTCAACGCC 
TTGTTCAACA ACCAGGCGTA CCACTCTCCA GCCACTGCCC TGGCCGTCGT GGACAACCTT 
CTGTTCAAGC TGCTGTGCGG GCCTCACGCC TCCATTGTGG TCTCCAACTT CCCCCAGCCC 
CGGAGCGCCC TGCAGGCTGC CAAGGACCAG TTTAACGAGG GCCGGAAGGG ATTCGACATT 
GCCCTCAACC TGCTCTTCGC CATGGCATTC TTGGCCAGCA CGTTCTCCAT CCTGGCGGTC 
AGCGAGAGGG CCGTGCAGGC CAAGCATGTG CAGTTTGTGA GTGGAGTCCA CGTGGCCAGT 
TTCTGGCTCT CTGCTCTGCT GTGGGACCTC ATCTCCTTCC TCATCCCCAG TCTGCTGCTG 
CTGGTGGTGT TTAAGGCCTT CGACGTGCGT GCCTTCACGC GGGACGGCCA CATGGCTGAC 
ACCCTGCTGC TGCTCCTGCT CTACGGCTGG GCCATCATCC CCCTCATGTA CCTGATGAAC 
TTCTTCTTCT TGGGGGCGGC CACTGCCTAC ACGAGGCTGA CCATCTTCAA CATCCTGTCA 
GGCATCGCCA CCTTCCTGAT GGTCACCATC ATGCGCATCC CAGCTGTAAA ACTGGAAGAA 
CTTTCCAAAA CCCTGGATCA CGTGTTCCTG GTGCTGCCCA ACCACTGTCT GGGGATGGCA 
GTCAGCAGTT TCTACGAGAA CTACGAGACG CGGAGGTACT GCACCTCCTC CGAGGTCGCC 
GCCCACTACT GCAAGAAATA TAACATCCAG TACCAGGAGA ACTTCTATGC CTGGAGCGCC 
CCGGGGGTCG GCCGGTTTGT GGCCTCCATG GCCGCCTCAG GGTGCGCCTA CCTCATCCTG 
CTCTTCCTCA TCGAGACCAA CCTGCTTCAG AGACTCAGGG GCATCCTCTG CGCCCTCCGG 
AGGAGGCGGA CACTGACAGA ATTATACACC CGGATGCCTG TGCTTCCTGA GGACCAAGAT 
GTAGCGGACG AGAGGACCCG CATCCTGGCC CCCAGCCCGG ACTCCCTGCT CCACACACCT 
CTGATTATCA AGGAGCTCTC CAAGGTGTAC GAGCAGCGGG TGCCCCTCCT GGCCGTGGAC 
AGGCTCTCCC TCGCGGTGCA GAAAGGGGAG TGCTTCGGCC TGCTGGGCTT CAATGGAGCC 
GGGAAGACCA CGACTTTCAA AATGCTGACC GGGGAGGAGA GCCTCACTTC TGGGGATGCC 
TTTGTCGGGG GTCACAGAAT CAGCTCTGAT GTCGGAAAGG TGCGGCAGCG GATCGGCTAC 
TGCCCGCAGT TTGATGCCTT GCTGGACCAC ATGACAGGCC GGGAGATGCT GGTCATGTAC 
GCTCGGCTCC GGGGCATCCC TGAGCGCCAC ATCGGGGCCT GCGTGGAGAA CACTCTGCGG 
GGCCTGCTGC TGGAGCCACA TGCCAACAAG CTGGTCAGGA CGTACAGTGG TGGTAACAAG 
CGGAAGCTGA GCACCGGCAT CGCCCTGATC GGAGAGCCTG CTGTCATCTT CCTGGACGAG 
CCGTCCACTG GCATGGACCC CGTGGCCCGG CGCCTGCTTT GGGACACCGT GGCACGAGCC 
CGAGAGTCTG GCAAGGCCAT CATCATCACC TCCCACAGCA TGGAGGAGTG TGAGGCCCTG 
TGCACCCGGC TGGCCATCAT GGTGCAGGGG CAGTTCAAGT GCCTGGGCAG CCCCCAGCAC 
CTCAAGAGCA AGTTCGGCAG CGGCTACTCC CTGCGGGCCA AGGTGCAGAG TGAAGGGCAA 
CAGGAGGCGC TGGAGGAGTT CAAGGCCTTC GTGGACCTGA CCTTTCCAGG CAGCGTCCTG 
GAAGATGAGC ACCAAGGCAT GGTCCATTAC CACCTGCCGG GCCGTGACCT CAGCTGGGCG 
AAGGTTTTCG GTATTCTGGA GAAAGCCAAG GAAAAGTACG GCGTGGACGA CTACTCCGTG 
AGCCAGATCT CGCTGGAACA GGTCTTCCTG AGCTTCGCCC ACCTGCAGCC GCCCACCGCA 
GAGGAGGGGC GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001080.2
CDS	713..5827
Translation	MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQSIQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDYIRYDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWHTTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIEEERTAVKLNTGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGRTVVPFSVPGTSQLGQQLSEHLKDALQAEGQEPREVLGDLEEFLIFRASVEGGGFNERCLVAASFRDVGERTVVNALFNNQAYHSPATALAVVDNLLFKLLCGPHASIVVSNFPQPRSALQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNHCLGMAVSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQRLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSVSQISLEQVFLSFAHLQPPTAEEGR

Target ORF information:

RefSeq Version	NM_001089.2
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP binding cassette subfamily A member 3 (ABCA3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001089.2

ORF Insert Sequence:

ATGGCTGTGC TCAGGCAGCT GGCGCTCCTC CTCTGGAAGA ACTACACCCT GCAGAAGCGG 
AAGGTCCTGG TGACGGTCCT GGAACTCTTC CTGCCATTGC TGTTTTCTGG GATCCTCATC 
TGGCTCCGCT TGAAGATTCA GTCGGAAAAT GTGCCCAACG CCACCATCTA CCCGGGCCAG 
TCCATCCAGG AGCTGCCTCT GTTCTTCACC TTCCCTCCGC CAGGAGACAC CTGGGAGCTT 
GCCTACATCC CTTCTCACAG TGACGCTGCC AAGACCGTCA CTGAGACAGT GCGCAGGGCA 
CTTGTGATCA ACATGCGAGT GCGCGGCTTT CCCTCCGAGA AGGACTTTGA GGACTACATT 
AGGTACGACA ACTGCTCGTC CAGCGTGCTG GCCGCCGTGG TCTTCGAGCA CCCCTTCAAC 
CACAGCAAGG AGCCCCTGCC GCTGGCGGTG AAATATCACC TACGGTTCAG TTACACACGG 
AGAAATTACA TGTGGACCCA AACAGGCTCC TTTTTCCTGA AAGAGACAGA AGGCTGGCAC 
ACTACTTCCC TTTTCCCGCT TTTCCCAAAC CCAGGACCAA GGGAACCTAC ATCCCCTGAT 
GGCGGAGAAC CTGGGTACAT CCGGGAAGGC TTCCTGGCCG TGCAGCATGC TGTGGACCGG 
GCCATCATGG AGTACCATGC CGATGCCGCC ACACGCCAGC TGTTCCAGAG ACTGACGGTG 
ACCATCAAGA GGTTCCCGTA CCCGCCGTTC ATCGCAGACC CCTTCCTCGT GGCCATCCAG 
TACCAGCTGC CCCTGCTGCT GCTGCTCAGC TTCACCTACA CCGCGCTCAC CATTGCCCGT 
GCTGTCGTGC AGGAGAAGGA AAGGAGGCTG AAGGAGTACA TGCGCATGAT GGGGCTCAGC 
AGCTGGCTGC ACTGGAGTGC CTGGTTCCTC TTGTTCTTCC TCTTCCTCCT CATCGCCGCC 
TCCTTCATGA CCCTGCTCTT CTGTGTCAAG GTGAAGCCAA ATGTAGCCGT GCTGTCCCGC 
AGCGACCCCT CCCTGGTGCT CGCCTTCCTG CTGTGCTTCG CCATCTCTAC CATCTCCTTC 
AGCTTCATGG TCAGCACCTT CTTCAGCAAA GCCAACATGG CAGCAGCCTT CGGAGGCTTC 
CTCTACTTCT TCACCTACAT CCCCTACTTC TTCGTGGCCC CTCGGTACAA CTGGATGACT 
CTGAGCCAGA AGCTCTGCTC CTGCCTCCTG TCTAATGTCG CCATGGCAAT GGGAGCCCAG 
CTCATTGGGA AATTTGAGGC GAAAGGCATG GGCATCCAGT GGCGAGACCT CCTGAGTCCC 
GTCAACGTGG ACGACGACTT CTGCTTCGGG CAGGTGCTGG GGATGCTGCT GCTGGACTCT 
GTGCTCTATG GCCTGGTGAC CTGGTACATG GAGGCCGTCT TCCCAGGGCA GTTCGGCGTG 
CCTCAGCCCT GGTACTTCTT CATCATGCCC TCCTATTGGT GTGGGAAGCC AAGGGCGGTT 
GCAGGGAAGG AGGAAGAAGA CAGTGACCCC GAGAAAGCAC TCAGAAACGA GTACTTTGAA 
GCCGAGCCAG AGGACCTGGT GGCGGGGATC AAGATCAAGC ACCTGTCCAA GGTGTTCAGG 
GTGGGAAATA AGGACAGGGC GGCCGTCAGA GACCTGAACC TCAACCTGTA CGAGGGACAG 
ATCACCGTCC TGCTGGGCCA CAACGGTGCC GGGAAGACCA CCACCCTCTC CATGCTCACA 
GGTCTCTTTC CCCCCACCAG TGGACGGGCA TACATCAGCG GGTATGAAAT TTCCCAGGAC 
ATGGTTCAGA TCCGGAAGAG CCTGGGCCTG TGCCCGCAGC ACGACATCCT GTTTGACAAC 
TTGACAGTCG CAGAGCACCT TTATTTCTAC GCCCAGCTGA AGGGCCTGTC ACGTCAGAAG 
TGCCCTGAAG AAGTCAAGCA GATGCTGCAC ATCATCGGCC TGGAGGACAA GTGGAACTCA 
CGGAGCCGCT TCCTGAGCGG GGGCATGAGG CGCAAGCTCT CCATCGGCAT CGCCCTCATC 
GCAGGCTCCA AGGTGCTGAT ACTGGACGAG CCCACCTCGG GCATGGACGC CATCTCCAGG 
AGGGCCATCT GGGATCTTCT TCAGCGGCAG AAAAGTGACC GCACCATCGT GCTGACCACC 
CACTTCATGG ACGAGGCTGA CCTGCTGGGA GACCGCATCG CCATCATGGC CAAGGGGGAG 
CTGCAGTGCT GCGGGTCCTC GCTGTTCCTC AAGCAGAAAT ACGGTGCCGG CTATCACATG 
ACGCTGGTGA AGGAGCCGCA CTGCAACCCG GAAGACATCT CCCAGCTGGT CCACCACCAC 
GTGCCCAACG CCACGCTGGA GAGCAGCGCT GGGGCCGAGC TGTCTTTCAT CCTTCCCAGA 
GAGAGCACGC ACAGGTTTGA AGGTCTCTTT GCTAAACTGG AGAAGAAGCA GAAAGAGCTG 
GGCATTGCCA GCTTTGGGGC ATCCATCACC ACCATGGAGG AAGTCTTCCT TCGGGTCGGG 
AAGCTGGTGG ACAGCAGTAT GGACATCCAG GCCATCCAGC TCCCTGCCCT GCAGTACCAG 
CACGAGAGGC GCGCCAGCGA CTGGGCTGTG GACAGCAACC TCTGTGGGGC CATGGACCCC 
TCCGACGGCA TTGGAGCCCT CATCGAGGAG GAGCGCACCG CTGTCAAGCT CAACACTGGG 
CTCGCCCTGC ACTGCCAGCA ATTCTGGGCC ATGTTCCTGA AGAAGGCCGC ATACAGCTGG 
CGCGAGTGGA AAATGGTGGC GGCACAGGTC CTGGTGCCTC TGACCTGCGT CACCCTGGCC 
CTCCTGGCCA TCAACTACTC CTCGGAGCTC TTCGACGACC CCATGCTGAG GCTGACCTTG 
GGCGAGTACG GCAGAACCGT CGTGCCCTTC TCAGTTCCCG GGACCTCCCA GCTGGGTCAG 
CAGCTGTCAG AGCATCTGAA AGACGCACTG CAGGCTGAGG GACAGGAGCC CCGCGAGGTG 
CTCGGTGACC TGGAGGAGTT CTTGATCTTC AGGGCTTCTG TGGAGGGGGG CGGCTTTAAT 
GAGCGGTGCC TTGTGGCAGC GTCCTTCAGA GATGTGGGAG AGCGCACGGT CGTCAACGCC 
TTGTTCAACA ACCAGGCGTA CCACTCTCCA GCCACTGCCC TGGCCGTCGT GGACAACCTT 
CTGTTCAAGC TGCTGTGCGG GCCTCACGCC TCCATTGTGG TCTCCAACTT CCCCCAGCCC 
CGGAGCGCCC TGCAGGCTGC CAAGGACCAG TTTAACGAGG GCCGGAAGGG ATTCGACATT 
GCCCTCAACC TGCTCTTCGC CATGGCATTC TTGGCCAGCA CGTTCTCCAT CCTGGCGGTC 
AGCGAGAGGG CCGTGCAGGC CAAGCATGTG CAGTTTGTGA GTGGAGTCCA CGTGGCCAGT 
TTCTGGCTCT CTGCTCTGCT GTGGGACCTC ATCTCCTTCC TCATCCCCAG TCTGCTGCTG 
CTGGTGGTGT TTAAGGCCTT CGACGTGCGT GCCTTCACGC GGGACGGCCA CATGGCTGAC 
ACCCTGCTGC TGCTCCTGCT CTACGGCTGG GCCATCATCC CCCTCATGTA CCTGATGAAC 
TTCTTCTTCT TGGGGGCGGC CACTGCCTAC ACGAGGCTGA CCATCTTCAA CATCCTGTCA 
GGCATCGCCA CCTTCCTGAT GGTCACCATC ATGCGCATCC CAGCTGTAAA ACTGGAAGAA 
CTTTCCAAAA CCCTGGATCA CGTGTTCCTG GTGCTGCCCA ACCACTGTCT GGGGATGGCA 
GTCAGCAGTT TCTACGAGAA CTACGAGACG CGGAGGTACT GCACCTCCTC CGAGGTCGCC 
GCCCACTACT GCAAGAAATA TAACATCCAG TACCAGGAGA ACTTCTATGC CTGGAGCGCC 
CCGGGGGTCG GCCGGTTTGT GGCCTCCATG GCCGCCTCAG GGTGCGCCTA CCTCATCCTG 
CTCTTCCTCA TCGAGACCAA CCTGCTTCAG AGACTCAGGG GCATCCTCTG CGCCCTCCGG 
AGGAGGCGGA CACTGACAGA ATTATACACC CGGATGCCTG TGCTTCCTGA GGACCAAGAT 
GTAGCGGACG AGAGGACCCG CATCCTGGCC CCCAGCCCGG ACTCCCTGCT CCACACACCT 
CTGATTATCA AGGAGCTCTC CAAGGTGTAC GAGCAGCGGG TGCCCCTCCT GGCCGTGGAC 
AGGCTCTCCC TCGCGGTGCA GAAAGGGGAG TGCTTCGGCC TGCTGGGCTT CAATGGAGCC 
GGGAAGACCA CGACTTTCAA AATGCTGACC GGGGAGGAGA GCCTCACTTC TGGGGATGCC 
TTTGTCGGGG GTCACAGAAT CAGCTCTGAT GTCGGAAAGG TGCGGCAGCG GATCGGCTAC 
TGCCCGCAGT TTGATGCCTT GCTGGACCAC ATGACAGGCC GGGAGATGCT GGTCATGTAC 
GCTCGGCTCC GGGGCATCCC TGAGCGCCAC ATCGGGGCCT GCGTGGAGAA CACTCTGCGG 
GGCCTGCTGC TGGAGCCACA TGCCAACAAG CTGGTCAGGA CGTACAGTGG TGGTAACAAG 
CGGAAGCTGA GCACCGGCAT CGCCCTGATC GGAGAGCCTG CTGTCATCTT CCTGGACGAG 
CCGTCCACTG GCATGGACCC CGTGGCCCGG CGCCTGCTTT GGGACACCGT GGCACGAGCC 
CGAGAGTCTG GCAAGGCCAT CATCATCACC TCCCACAGCA TGGAGGAGTG TGAGGCCCTG 
TGCACCCGGC TGGCCATCAT GGTGCAGGGG CAGTTCAAGT GCCTGGGCAG CCCCCAGCAC 
CTCAAGAGCA AGTTCGGCAG CGGCTACTCC CTGCGGGCCA AGGTGCAGAG TGAAGGGCAA 
CAGGAGGCGC TGGAGGAGTT CAAGGCCTTC GTGGACCTGA CCTTTCCAGG CAGCGTCCTG 
GAAGATGAGC ACCAAGGCAT GGTCCATTAC CACCTGCCGG GCCGTGACCT CAGCTGGGCG 
AAGGTTTTCG GTATTCTGGA GAAAGCCAAG GAAAAGTACG GCGTGGACGA CTACTCCGTG 
AGCCAGATCT CGCTGGAACA GGTCTTCCTG AGCTTCGCCC ACCTGCAGCC GCCCACCGCA 
GAGGAGGGGC GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

ABCA3 ( NM_001089.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001080.2 Homo sapiens ATP binding cassette subfamily A member 3 (ABCA3), mRNA.

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CloneID	OHu107214
Clone ID Related Accession (Same CDS sequence)	NM_001089.3
Accession Version	NM_001089.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 5115bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	ATP-binding cassette sub-family A member 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC106820.4, AC098805.2 and AC009065.8. On Nov 22, 2018 this sequence version replaced NM_001089.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC151840.1, SRR1803611.170505.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000301732.10/ ENSP00000301732.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTGTGC TCAGGCAGCT GGCGCTCCTC CTCTGGAAGA ACTACACCCT GCAGAAGCGG 
AAGGTCCTGG TGACGGTCCT GGAACTCTTC CTGCCATTGC TGTTTTCTGG GATCCTCATC 
TGGCTCCGCT TGAAGATTCA GTCGGAAAAT GTGCCCAACG CCACCATCTA CCCGGGCCAG 
TCCATCCAGG AGCTGCCTCT GTTCTTCACC TTCCCTCCGC CAGGAGACAC CTGGGAGCTT 
GCCTACATCC CTTCTCACAG TGACGCTGCC AAGACCGTCA CTGAGACAGT GCGCAGGGCA 
CTTGTGATCA ACATGCGAGT GCGCGGCTTT CCCTCCGAGA AGGACTTTGA GGACTACATT 
AGGTACGACA ACTGCTCGTC CAGCGTGCTG GCCGCCGTGG TCTTCGAGCA CCCCTTCAAC 
CACAGCAAGG AGCCCCTGCC GCTGGCGGTG AAATATCACC TACGGTTCAG TTACACACGG 
AGAAATTACA TGTGGACCCA AACAGGCTCC TTTTTCCTGA AAGAGACAGA AGGCTGGCAC 
ACTACTTCCC TTTTCCCGCT TTTCCCAAAC CCAGGACCAA GGGAACCTAC ATCCCCTGAT 
GGCGGAGAAC CTGGGTACAT CCGGGAAGGC TTCCTGGCCG TGCAGCATGC TGTGGACCGG 
GCCATCATGG AGTACCATGC CGATGCCGCC ACACGCCAGC TGTTCCAGAG ACTGACGGTG 
ACCATCAAGA GGTTCCCGTA CCCGCCGTTC ATCGCAGACC CCTTCCTCGT GGCCATCCAG 
TACCAGCTGC CCCTGCTGCT GCTGCTCAGC TTCACCTACA CCGCGCTCAC CATTGCCCGT 
GCTGTCGTGC AGGAGAAGGA AAGGAGGCTG AAGGAGTACA TGCGCATGAT GGGGCTCAGC 
AGCTGGCTGC ACTGGAGTGC CTGGTTCCTC TTGTTCTTCC TCTTCCTCCT CATCGCCGCC 
TCCTTCATGA CCCTGCTCTT CTGTGTCAAG GTGAAGCCAA ATGTAGCCGT GCTGTCCCGC 
AGCGACCCCT CCCTGGTGCT CGCCTTCCTG CTGTGCTTCG CCATCTCTAC CATCTCCTTC 
AGCTTCATGG TCAGCACCTT CTTCAGCAAA GCCAACATGG CAGCAGCCTT CGGAGGCTTC 
CTCTACTTCT TCACCTACAT CCCCTACTTC TTCGTGGCCC CTCGGTACAA CTGGATGACT 
CTGAGCCAGA AGCTCTGCTC CTGCCTCCTG TCTAATGTCG CCATGGCAAT GGGAGCCCAG 
CTCATTGGGA AATTTGAGGC GAAAGGCATG GGCATCCAGT GGCGAGACCT CCTGAGTCCC 
GTCAACGTGG ACGACGACTT CTGCTTCGGG CAGGTGCTGG GGATGCTGCT GCTGGACTCT 
GTGCTCTATG GCCTGGTGAC CTGGTACATG GAGGCCGTCT TCCCAGGGCA GTTCGGCGTG 
CCTCAGCCCT GGTACTTCTT CATCATGCCC TCCTATTGGT GTGGGAAGCC AAGGGCGGTT 
GCAGGGAAGG AGGAAGAAGA CAGTGACCCC GAGAAAGCAC TCAGAAACGA GTACTTTGAA 
GCCGAGCCAG AGGACCTGGT GGCGGGGATC AAGATCAAGC ACCTGTCCAA GGTGTTCAGG 
GTGGGAAATA AGGACAGGGC GGCCGTCAGA GACCTGAACC TCAACCTGTA CGAGGGACAG 
ATCACCGTCC TGCTGGGCCA CAACGGTGCC GGGAAGACCA CCACCCTCTC CATGCTCACA 
GGTCTCTTTC CCCCCACCAG TGGACGGGCA TACATCAGCG GGTATGAAAT TTCCCAGGAC 
ATGGTTCAGA TCCGGAAGAG CCTGGGCCTG TGCCCGCAGC ACGACATCCT GTTTGACAAC 
TTGACAGTCG CAGAGCACCT TTATTTCTAC GCCCAGCTGA AGGGCCTGTC ACGTCAGAAG 
TGCCCTGAAG AAGTCAAGCA GATGCTGCAC ATCATCGGCC TGGAGGACAA GTGGAACTCA 
CGGAGCCGCT TCCTGAGCGG GGGCATGAGG CGCAAGCTCT CCATCGGCAT CGCCCTCATC 
GCAGGCTCCA AGGTGCTGAT ACTGGACGAG CCCACCTCGG GCATGGACGC CATCTCCAGG 
AGGGCCATCT GGGATCTTCT TCAGCGGCAG AAAAGTGACC GCACCATCGT GCTGACCACC 
CACTTCATGG ACGAGGCTGA CCTGCTGGGA GACCGCATCG CCATCATGGC CAAGGGGGAG 
CTGCAGTGCT GCGGGTCCTC GCTGTTCCTC AAGCAGAAAT ACGGTGCCGG CTATCACATG 
ACGCTGGTGA AGGAGCCGCA CTGCAACCCG GAAGACATCT CCCAGCTGGT CCACCACCAC 
GTGCCCAACG CCACGCTGGA GAGCAGCGCT GGGGCCGAGC TGTCTTTCAT CCTTCCCAGA 
GAGAGCACGC ACAGGTTTGA AGGTCTCTTT GCTAAACTGG AGAAGAAGCA GAAAGAGCTG 
GGCATTGCCA GCTTTGGGGC ATCCATCACC ACCATGGAGG AAGTCTTCCT TCGGGTCGGG 
AAGCTGGTGG ACAGCAGTAT GGACATCCAG GCCATCCAGC TCCCTGCCCT GCAGTACCAG 
CACGAGAGGC GCGCCAGCGA CTGGGCTGTG GACAGCAACC TCTGTGGGGC CATGGACCCC 
TCCGACGGCA TTGGAGCCCT CATCGAGGAG GAGCGCACCG CTGTCAAGCT CAACACTGGG 
CTCGCCCTGC ACTGCCAGCA ATTCTGGGCC ATGTTCCTGA AGAAGGCCGC ATACAGCTGG 
CGCGAGTGGA AAATGGTGGC GGCACAGGTC CTGGTGCCTC TGACCTGCGT CACCCTGGCC 
CTCCTGGCCA TCAACTACTC CTCGGAGCTC TTCGACGACC CCATGCTGAG GCTGACCTTG 
GGCGAGTACG GCAGAACCGT CGTGCCCTTC TCAGTTCCCG GGACCTCCCA GCTGGGTCAG 
CAGCTGTCAG AGCATCTGAA AGACGCACTG CAGGCTGAGG GACAGGAGCC CCGCGAGGTG 
CTCGGTGACC TGGAGGAGTT CTTGATCTTC AGGGCTTCTG TGGAGGGGGG CGGCTTTAAT 
GAGCGGTGCC TTGTGGCAGC GTCCTTCAGA GATGTGGGAG AGCGCACGGT CGTCAACGCC 
TTGTTCAACA ACCAGGCGTA CCACTCTCCA GCCACTGCCC TGGCCGTCGT GGACAACCTT 
CTGTTCAAGC TGCTGTGCGG GCCTCACGCC TCCATTGTGG TCTCCAACTT CCCCCAGCCC 
CGGAGCGCCC TGCAGGCTGC CAAGGACCAG TTTAACGAGG GCCGGAAGGG ATTCGACATT 
GCCCTCAACC TGCTCTTCGC CATGGCATTC TTGGCCAGCA CGTTCTCCAT CCTGGCGGTC 
AGCGAGAGGG CCGTGCAGGC CAAGCATGTG CAGTTTGTGA GTGGAGTCCA CGTGGCCAGT 
TTCTGGCTCT CTGCTCTGCT GTGGGACCTC ATCTCCTTCC TCATCCCCAG TCTGCTGCTG 
CTGGTGGTGT TTAAGGCCTT CGACGTGCGT GCCTTCACGC GGGACGGCCA CATGGCTGAC 
ACCCTGCTGC TGCTCCTGCT CTACGGCTGG GCCATCATCC CCCTCATGTA CCTGATGAAC 
TTCTTCTTCT TGGGGGCGGC CACTGCCTAC ACGAGGCTGA CCATCTTCAA CATCCTGTCA 
GGCATCGCCA CCTTCCTGAT GGTCACCATC ATGCGCATCC CAGCTGTAAA ACTGGAAGAA 
CTTTCCAAAA CCCTGGATCA CGTGTTCCTG GTGCTGCCCA ACCACTGTCT GGGGATGGCA 
GTCAGCAGTT TCTACGAGAA CTACGAGACG CGGAGGTACT GCACCTCCTC CGAGGTCGCC 
GCCCACTACT GCAAGAAATA TAACATCCAG TACCAGGAGA ACTTCTATGC CTGGAGCGCC 
CCGGGGGTCG GCCGGTTTGT GGCCTCCATG GCCGCCTCAG GGTGCGCCTA CCTCATCCTG 
CTCTTCCTCA TCGAGACCAA CCTGCTTCAG AGACTCAGGG GCATCCTCTG CGCCCTCCGG 
AGGAGGCGGA CACTGACAGA ATTATACACC CGGATGCCTG TGCTTCCTGA GGACCAAGAT 
GTAGCGGACG AGAGGACCCG CATCCTGGCC CCCAGTCCGG ACTCCCTGCT CCACACACCT 
CTGATTATCA AGGAGCTCTC CAAGGTGTAC GAGCAGCGGG TGCCCCTCCT GGCCGTGGAC 
AGGCTCTCCC TCGCGGTGCA GAAAGGGGAG TGCTTCGGCC TGCTGGGCTT CAATGGAGCC 
GGGAAGACCA CGACTTTCAA AATGCTGACC GGGGAGGAGA GCCTCACTTC TGGGGATGCC 
TTTGTCGGGG GTCACAGAAT CAGCTCTGAT GTCGGAAAGG TGCGGCAGCG GATCGGCTAC 
TGCCCGCAGT TTGATGCCTT GCTGGACCAC ATGACAGGCC GGGAGATGCT GGTCATGTAC 
GCTCGGCTCC GGGGCATCCC TGAGCGCCAC ATCGGGGCCT GCGTGGAGAA CACTCTGCGG 
GGCCTGCTGC TGGAGCCACA TGCCAACAAG CTGGTCAGGA CGTACAGTGG TGGTAACAAG 
CGGAAGCTGA GCACCGGCAT CGCCCTGATC GGAGAGCCTG CTGTCATCTT CCTGGACGAG 
CCGTCCACTG GCATGGACCC CGTGGCCCGG CGCCTGCTTT GGGACACCGT GGCACGAGCC 
CGAGAGTCTG GCAAGGCCAT CATCATCACC TCCCACAGCA TGGAGGAGTG TGAGGCCCTG 
TGCACCCGGC TGGCCATCAT GGTGCAGGGG CAGTTCAAGT GCCTGGGCAG CCCCCAGCAC 
CTCAAGAGCA AGTTCGGCAG CGGCTACTCC CTGCGGGCCA AGGTGCAGAG TGAAGGGCAA 
CAGGAGGCGC TGGAGGAGTT CAAGGCCTTC GTGGACCTGA CCTTTCCAGG CAGCGTCCTG 
GAAGATGAGC ACCAAGGCAT GGTCCATTAC CACCTGCCGG GCCGTGACCT CAGCTGGGCG 
AAGGTTTTCG GTATTCTGGA GAAAGCCAAG GAAAAGTACG GCGTGGACGA CTACTCCGTG 
AGCCAGATCT CGCTGGAACA GGTCTTCCTG AGCTTCGCCC ACCTGCAGCC GCCCACCGCA 
GAGGAGGGGC GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001080.2
CDS	695..5809
Translation	MAVLRQLALLLWKNYTLQKRKVLVTVLELFLPLLFSGILIWLRLKIQSENVPNATIYPGQSIQELPLFFTFPPPGDTWELAYIPSHSDAAKTVTETVRRALVINMRVRGFPSEKDFEDYIRYDNCSSSVLAAVVFEHPFNHSKEPLPLAVKYHLRFSYTRRNYMWTQTGSFFLKETEGWHTTSLFPLFPNPGPREPTSPDGGEPGYIREGFLAVQHAVDRAIMEYHADAATRQLFQRLTVTIKRFPYPPFIADPFLVAIQYQLPLLLLLSFTYTALTIARAVVQEKERRLKEYMRMMGLSSWLHWSAWFLLFFLFLLIAASFMTLLFCVKVKPNVAVLSRSDPSLVLAFLLCFAISTISFSFMVSTFFSKANMAAAFGGFLYFFTYIPYFFVAPRYNWMTLSQKLCSCLLSNVAMAMGAQLIGKFEAKGMGIQWRDLLSPVNVDDDFCFGQVLGMLLLDSVLYGLVTWYMEAVFPGQFGVPQPWYFFIMPSYWCGKPRAVAGKEEEDSDPEKALRNEYFEAEPEDLVAGIKIKHLSKVFRVGNKDRAAVRDLNLNLYEGQITVLLGHNGAGKTTTLSMLTGLFPPTSGRAYISGYEISQDMVQIRKSLGLCPQHDILFDNLTVAEHLYFYAQLKGLSRQKCPEEVKQMLHIIGLEDKWNSRSRFLSGGMRRKLSIGIALIAGSKVLILDEPTSGMDAISRRAIWDLLQRQKSDRTIVLTTHFMDEADLLGDRIAIMAKGELQCCGSSLFLKQKYGAGYHMTLVKEPHCNPEDISQLVHHHVPNATLESSAGAELSFILPRESTHRFEGLFAKLEKKQKELGIASFGASITTMEEVFLRVGKLVDSSMDIQAIQLPALQYQHERRASDWAVDSNLCGAMDPSDGIGALIEEERTAVKLNTGLALHCQQFWAMFLKKAAYSWREWKMVAAQVLVPLTCVTLALLAINYSSELFDDPMLRLTLGEYGRTVVPFSVPGTSQLGQQLSEHLKDALQAEGQEPREVLGDLEEFLIFRASVEGGGFNERCLVAASFRDVGERTVVNALFNNQAYHSPATALAVVDNLLFKLLCGPHASIVVSNFPQPRSALQAAKDQFNEGRKGFDIALNLLFAMAFLASTFSILAVSERAVQAKHVQFVSGVHVASFWLSALLWDLISFLIPSLLLLVVFKAFDVRAFTRDGHMADTLLLLLLYGWAIIPLMYLMNFFFLGAATAYTRLTIFNILSGIATFLMVTIMRIPAVKLEELSKTLDHVFLVLPNHCLGMAVSSFYENYETRRYCTSSEVAAHYCKKYNIQYQENFYAWSAPGVGRFVASMAASGCAYLILLFLIETNLLQRLRGILCALRRRRTLTELYTRMPVLPEDQDVADERTRILAPSPDSLLHTPLIIKELSKVYEQRVPLLAVDRLSLAVQKGECFGLLGFNGAGKTTTFKMLTGEESLTSGDAFVGGHRISSDVGKVRQRIGYCPQFDALLDHMTGREMLVMYARLRGIPERHIGACVENTLRGLLLEPHANKLVRTYSGGNKRKLSTGIALIGEPAVIFLDEPSTGMDPVARRLLWDTVARARESGKAIIITSHSMEECEALCTRLAIMVQGQFKCLGSPQHLKSKFGSGYSLRAKVQSEGQQEALEEFKAFVDLTFPGSVLEDEHQGMVHYHLPGRDLSWAKVFGILEKAKEKYGVDDYSVSQISLEQVFLSFAHLQPPTAEEGR

Target ORF information:

RefSeq Version	NM_001089.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ATP binding cassette subfamily A member 3 (ABCA3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001089.3

ORF Insert Sequence:

ATGGCTGTGC TCAGGCAGCT GGCGCTCCTC CTCTGGAAGA ACTACACCCT GCAGAAGCGG 
AAGGTCCTGG TGACGGTCCT GGAACTCTTC CTGCCATTGC TGTTTTCTGG GATCCTCATC 
TGGCTCCGCT TGAAGATTCA GTCGGAAAAT GTGCCCAACG CCACCATCTA CCCGGGCCAG 
TCCATCCAGG AGCTGCCTCT GTTCTTCACC TTCCCTCCGC CAGGAGACAC CTGGGAGCTT 
GCCTACATCC CTTCTCACAG TGACGCTGCC AAGACCGTCA CTGAGACAGT GCGCAGGGCA 
CTTGTGATCA ACATGCGAGT GCGCGGCTTT CCCTCCGAGA AGGACTTTGA GGACTACATT 
AGGTACGACA ACTGCTCGTC CAGCGTGCTG GCCGCCGTGG TCTTCGAGCA CCCCTTCAAC 
CACAGCAAGG AGCCCCTGCC GCTGGCGGTG AAATATCACC TACGGTTCAG TTACACACGG 
AGAAATTACA TGTGGACCCA AACAGGCTCC TTTTTCCTGA AAGAGACAGA AGGCTGGCAC 
ACTACTTCCC TTTTCCCGCT TTTCCCAAAC CCAGGACCAA GGGAACCTAC ATCCCCTGAT 
GGCGGAGAAC CTGGGTACAT CCGGGAAGGC TTCCTGGCCG TGCAGCATGC TGTGGACCGG 
GCCATCATGG AGTACCATGC CGATGCCGCC ACACGCCAGC TGTTCCAGAG ACTGACGGTG 
ACCATCAAGA GGTTCCCGTA CCCGCCGTTC ATCGCAGACC CCTTCCTCGT GGCCATCCAG 
TACCAGCTGC CCCTGCTGCT GCTGCTCAGC TTCACCTACA CCGCGCTCAC CATTGCCCGT 
GCTGTCGTGC AGGAGAAGGA AAGGAGGCTG AAGGAGTACA TGCGCATGAT GGGGCTCAGC 
AGCTGGCTGC ACTGGAGTGC CTGGTTCCTC TTGTTCTTCC TCTTCCTCCT CATCGCCGCC 
TCCTTCATGA CCCTGCTCTT CTGTGTCAAG GTGAAGCCAA ATGTAGCCGT GCTGTCCCGC 
AGCGACCCCT CCCTGGTGCT CGCCTTCCTG CTGTGCTTCG CCATCTCTAC CATCTCCTTC 
AGCTTCATGG TCAGCACCTT CTTCAGCAAA GCCAACATGG CAGCAGCCTT CGGAGGCTTC 
CTCTACTTCT TCACCTACAT CCCCTACTTC TTCGTGGCCC CTCGGTACAA CTGGATGACT 
CTGAGCCAGA AGCTCTGCTC CTGCCTCCTG TCTAATGTCG CCATGGCAAT GGGAGCCCAG 
CTCATTGGGA AATTTGAGGC GAAAGGCATG GGCATCCAGT GGCGAGACCT CCTGAGTCCC 
GTCAACGTGG ACGACGACTT CTGCTTCGGG CAGGTGCTGG GGATGCTGCT GCTGGACTCT 
GTGCTCTATG GCCTGGTGAC CTGGTACATG GAGGCCGTCT TCCCAGGGCA GTTCGGCGTG 
CCTCAGCCCT GGTACTTCTT CATCATGCCC TCCTATTGGT GTGGGAAGCC AAGGGCGGTT 
GCAGGGAAGG AGGAAGAAGA CAGTGACCCC GAGAAAGCAC TCAGAAACGA GTACTTTGAA 
GCCGAGCCAG AGGACCTGGT GGCGGGGATC AAGATCAAGC ACCTGTCCAA GGTGTTCAGG 
GTGGGAAATA AGGACAGGGC GGCCGTCAGA GACCTGAACC TCAACCTGTA CGAGGGACAG 
ATCACCGTCC TGCTGGGCCA CAACGGTGCC GGGAAGACCA CCACCCTCTC CATGCTCACA 
GGTCTCTTTC CCCCCACCAG TGGACGGGCA TACATCAGCG GGTATGAAAT TTCCCAGGAC 
ATGGTTCAGA TCCGGAAGAG CCTGGGCCTG TGCCCGCAGC ACGACATCCT GTTTGACAAC 
TTGACAGTCG CAGAGCACCT TTATTTCTAC GCCCAGCTGA AGGGCCTGTC ACGTCAGAAG 
TGCCCTGAAG AAGTCAAGCA GATGCTGCAC ATCATCGGCC TGGAGGACAA GTGGAACTCA 
CGGAGCCGCT TCCTGAGCGG GGGCATGAGG CGCAAGCTCT CCATCGGCAT CGCCCTCATC 
GCAGGCTCCA AGGTGCTGAT ACTGGACGAG CCCACCTCGG GCATGGACGC CATCTCCAGG 
AGGGCCATCT GGGATCTTCT TCAGCGGCAG AAAAGTGACC GCACCATCGT GCTGACCACC 
CACTTCATGG ACGAGGCTGA CCTGCTGGGA GACCGCATCG CCATCATGGC CAAGGGGGAG 
CTGCAGTGCT GCGGGTCCTC GCTGTTCCTC AAGCAGAAAT ACGGTGCCGG CTATCACATG 
ACGCTGGTGA AGGAGCCGCA CTGCAACCCG GAAGACATCT CCCAGCTGGT CCACCACCAC 
GTGCCCAACG CCACGCTGGA GAGCAGCGCT GGGGCCGAGC TGTCTTTCAT CCTTCCCAGA 
GAGAGCACGC ACAGGTTTGA AGGTCTCTTT GCTAAACTGG AGAAGAAGCA GAAAGAGCTG 
GGCATTGCCA GCTTTGGGGC ATCCATCACC ACCATGGAGG AAGTCTTCCT TCGGGTCGGG 
AAGCTGGTGG ACAGCAGTAT GGACATCCAG GCCATCCAGC TCCCTGCCCT GCAGTACCAG 
CACGAGAGGC GCGCCAGCGA CTGGGCTGTG GACAGCAACC TCTGTGGGGC CATGGACCCC 
TCCGACGGCA TTGGAGCCCT CATCGAGGAG GAGCGCACCG CTGTCAAGCT CAACACTGGG 
CTCGCCCTGC ACTGCCAGCA ATTCTGGGCC ATGTTCCTGA AGAAGGCCGC ATACAGCTGG 
CGCGAGTGGA AAATGGTGGC GGCACAGGTC CTGGTGCCTC TGACCTGCGT CACCCTGGCC 
CTCCTGGCCA TCAACTACTC CTCGGAGCTC TTCGACGACC CCATGCTGAG GCTGACCTTG 
GGCGAGTACG GCAGAACCGT CGTGCCCTTC TCAGTTCCCG GGACCTCCCA GCTGGGTCAG 
CAGCTGTCAG AGCATCTGAA AGACGCACTG CAGGCTGAGG GACAGGAGCC CCGCGAGGTG 
CTCGGTGACC TGGAGGAGTT CTTGATCTTC AGGGCTTCTG TGGAGGGGGG CGGCTTTAAT 
GAGCGGTGCC TTGTGGCAGC GTCCTTCAGA GATGTGGGAG AGCGCACGGT CGTCAACGCC 
TTGTTCAACA ACCAGGCGTA CCACTCTCCA GCCACTGCCC TGGCCGTCGT GGACAACCTT 
CTGTTCAAGC TGCTGTGCGG GCCTCACGCC TCCATTGTGG TCTCCAACTT CCCCCAGCCC 
CGGAGCGCCC TGCAGGCTGC CAAGGACCAG TTTAACGAGG GCCGGAAGGG ATTCGACATT 
GCCCTCAACC TGCTCTTCGC CATGGCATTC TTGGCCAGCA CGTTCTCCAT CCTGGCGGTC 
AGCGAGAGGG CCGTGCAGGC CAAGCATGTG CAGTTTGTGA GTGGAGTCCA CGTGGCCAGT 
TTCTGGCTCT CTGCTCTGCT GTGGGACCTC ATCTCCTTCC TCATCCCCAG TCTGCTGCTG 
CTGGTGGTGT TTAAGGCCTT CGACGTGCGT GCCTTCACGC GGGACGGCCA CATGGCTGAC 
ACCCTGCTGC TGCTCCTGCT CTACGGCTGG GCCATCATCC CCCTCATGTA CCTGATGAAC 
TTCTTCTTCT TGGGGGCGGC CACTGCCTAC ACGAGGCTGA CCATCTTCAA CATCCTGTCA 
GGCATCGCCA CCTTCCTGAT GGTCACCATC ATGCGCATCC CAGCTGTAAA ACTGGAAGAA 
CTTTCCAAAA CCCTGGATCA CGTGTTCCTG GTGCTGCCCA ACCACTGTCT GGGGATGGCA 
GTCAGCAGTT TCTACGAGAA CTACGAGACG CGGAGGTACT GCACCTCCTC CGAGGTCGCC 
GCCCACTACT GCAAGAAATA TAACATCCAG TACCAGGAGA ACTTCTATGC CTGGAGCGCC 
CCGGGGGTCG GCCGGTTTGT GGCCTCCATG GCCGCCTCAG GGTGCGCCTA CCTCATCCTG 
CTCTTCCTCA TCGAGACCAA CCTGCTTCAG AGACTCAGGG GCATCCTCTG CGCCCTCCGG 
AGGAGGCGGA CACTGACAGA ATTATACACC CGGATGCCTG TGCTTCCTGA GGACCAAGAT 
GTAGCGGACG AGAGGACCCG CATCCTGGCC CCCAGTCCGG ACTCCCTGCT CCACACACCT 
CTGATTATCA AGGAGCTCTC CAAGGTGTAC GAGCAGCGGG TGCCCCTCCT GGCCGTGGAC 
AGGCTCTCCC TCGCGGTGCA GAAAGGGGAG TGCTTCGGCC TGCTGGGCTT CAATGGAGCC 
GGGAAGACCA CGACTTTCAA AATGCTGACC GGGGAGGAGA GCCTCACTTC TGGGGATGCC 
TTTGTCGGGG GTCACAGAAT CAGCTCTGAT GTCGGAAAGG TGCGGCAGCG GATCGGCTAC 
TGCCCGCAGT TTGATGCCTT GCTGGACCAC ATGACAGGCC GGGAGATGCT GGTCATGTAC 
GCTCGGCTCC GGGGCATCCC TGAGCGCCAC ATCGGGGCCT GCGTGGAGAA CACTCTGCGG 
GGCCTGCTGC TGGAGCCACA TGCCAACAAG CTGGTCAGGA CGTACAGTGG TGGTAACAAG 
CGGAAGCTGA GCACCGGCAT CGCCCTGATC GGAGAGCCTG CTGTCATCTT CCTGGACGAG 
CCGTCCACTG GCATGGACCC CGTGGCCCGG CGCCTGCTTT GGGACACCGT GGCACGAGCC 
CGAGAGTCTG GCAAGGCCAT CATCATCACC TCCCACAGCA TGGAGGAGTG TGAGGCCCTG 
TGCACCCGGC TGGCCATCAT GGTGCAGGGG CAGTTCAAGT GCCTGGGCAG CCCCCAGCAC 
CTCAAGAGCA AGTTCGGCAG CGGCTACTCC CTGCGGGCCA AGGTGCAGAG TGAAGGGCAA 
CAGGAGGCGC TGGAGGAGTT CAAGGCCTTC GTGGACCTGA CCTTTCCAGG CAGCGTCCTG 
GAAGATGAGC ACCAAGGCAT GGTCCATTAC CACCTGCCGG GCCGTGACCT CAGCTGGGCG 
AAGGTTTTCG GTATTCTGGA GAAAGCCAAG GAAAAGTACG GCGTGGACGA CTACTCCGTG 
AGCCAGATCT CGCTGGAACA GGTCTTCCTG AGCTTCGCCC ACCTGCAGCC GCCCACCGCA 
GAGGAGGGGC GATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Functional rescue of misfolding ABCA3 mutations by small molecular correctors.
Human molecular genetics(2018 Jan)
Kinting S,H?ppner S,Schindlbeck U,Forstner ME,Harfst J,Wittmann T,Griese M

Surfactant proteins gene variants in premature newborn infants with severe respiratory distress syndrome.
Journal of perinatology : official journal of the California Perinatal Association(2017 Dec)
Somaschini M,Presi S,Ferrari M,Vergani B,Carrera P

Quantification of volume and lipid filling of intracellular vesicles carrying the ABCA3 transporter.
Biochimica et biophysica acta1864(12)2330-2335(2017 12)
H?ppner S,Kinting S,Torrano AA,Schindlbeck U,Br?uchle C,Zarbock R,Wittmann T,Griese M

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ABCA3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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