FBL cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FBL
Entrez Gene ID	2091
Full Name	fibrillarin
Synonyms	FIB,FLRN,Nop1,RNU3IP1
General protein information	Preferred Names fibrillarin Names rRNA 2'-O-methyltransferase fibrillarin 34 kDa nucleolar scleroderma antigen 34-kD nucleolar scleroderma antigen RNA, U3 small nucleolar interacting protein 1 histone-glutamine methyltransferase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.2
Summary	This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008].
Disorder MIM:	134795

mRNA and Protein(s)

mRNA	Protein	Name
XM_005258651.2	XP_005258708.1	rRNA 2'-O-methyltransferase fibrillarin isoform X1
NM_001436.3	NP_001427.2	rRNA 2'-O-methyltransferase fibrillarin
XM_011526623.2	XP_011524925.1	rRNA 2'-O-methyltransferase fibrillarin isoform X2
NM_001436.4	NP_001427.2	rRNA 2'-O-methyltransferase fibrillarin

Pathways from BioSystems

Homologies

	FBL	XP_001088664.2
Danio rerio (zebrafish)	fbl	NP_998167.1
Saccharomyces cerevisiae (baker's yeast)	NOP1	NP_010270.1
Arabidopsis thaliana (thale cress)	FIB2	NP_567724.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP011244	XP_309401.4
Homo sapiens (human)	FBL	NP_001427.2
Bos taurus (cattle)	FBL	NP_001192329.1
Rattus norvegicus (Norway rat)	Fbl	NP_001020814.1
Eremothecium gossypii	AGOS_AER214C	NP_985071.1
Magnaporthe oryzae (rice blast fungus)	MGG_09195	XP_003709808.1
Oryza sativa (rice)	Os02g0821800	NP_001048553.1
Xenopus tropicalis (tropical clawed frog)	fbl	NP_989101.1
Pan troglodytes (chimpanzee)	FBL	XP_512658.2
Mus musculus (house mouse)	Fbl	NP_032017.2
Drosophila melanogaster (fruit fly)	Fib	NP_523817.1
Caenorhabditis elegans (roundworm)	fib-1	NP_506691.1
Neurospora crassa	NCU03702	XP_961478.1
Canis lupus familiaris (dog)	FBL	XP_533671.3
Kluyveromyces lactis	KLLA0C04389g	XP_452393.1
Schizosaccharomyces pombe (fission yeast)	fib1	NP_596229.1
Arabidopsis thaliana (thale cress)	FIB1	NP_568772.3

Gene Ontology
Bibliography

Related articles in PubMed

Architecture of the human interactome defines protein communities and disease networks.
Huttlin EL, Bruckner RJ, Paulo JA, Cannon JR, Ting L, Baltier K, Colby G, Gebreab F, Gygi MP, Parzen H, Szpyt J, Tam S, Zarraga G, Pontano-Vaites L, Swarup S, White AE, Schweppe DK, Rad R, Erickson BK, Obar RA, Guruharsha KG, Li K, Artavanis-Tsakonas S, Gygi SP, Harper JW
Nature545(7655)505-509(2017 05)

Nucleolar Methyltransferase Fibrillarin: Evolution of Structure and Functions.
Shubina MY, Musinova YR, Sheval EV
Biochemistry. Biokhimiia81(9)941-50(2016 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Nucleolar Methyltransferase Fibrillarin: Evolution of Structure and Functions.
Title: Nucleolar Methyltransferase Fibrillarin: Evolution of Structure and Functions.

FBL overexpression contributes to tumorigenesis and is associated with poor survival in patients with breast cancer.
Title: p53 acts as a safeguard of translational control by regulating fibrillarin and rRNA methylation in cancer.

NS1 protein of the human H3N2 virus interacts primarily via the C-terminal NLS2/NoLS and to a minor extent via the N-terminal NLS1 with the main nucleolar proteins, nucleolin, B23 and fibrillarin.
Title: Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin.

p32 is a new rRNA maturation factor involved in the remodeling from pre-90S particles to pre-40S and pre-60S particles that requires the exchange of FBL for Nop52.
Title: Splicing factor 2-associated protein p32 participates in ribosome biogenesis by regulating the binding of Nop52 and fibrillarin to preribosome particles.

Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

The following FBL gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FBL cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02938	NM_001436.4 Latest version!	Homo sapiens fibrillarin (FBL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu52106	XM_005258651.2 Latest version!	Homo sapiens fibrillarin (FBL), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
OHu57575	XM_011526623.2 Latest version!	Homo sapiens fibrillarin (FBL), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
View Old Accession Versions >>
OHu02938	NM_001436.3	Homo sapiens fibrillarin (FBL), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FBL ( NM_001436.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001427.2 Homo sapiens fibrillarin (FBL), mRNA.

Price & Availability↑

CloneID	OHu02938
Clone ID Related Accession (Same CDS sequence)	NM_001436.3 , NM_001436.4
Accession Version	NM_001436.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-30
Organism	Homo sapiens(human)
Product	rRNA 2'-O-methyltransferase fibrillarin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG831506.1, BC019260.1 and AI085380.1. On Nov 27, 2008 this sequence version replaced NM_001436.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1163655.644315.1, SRR1163655.559865.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAAGCCAG GATTCAGTCC CCGTGGGGGT GGCTTTGGCG GCCGAGGGGG CTTTGGTGAC 
CGTGGTGGTC GTGGAGGCCG AGGGGGCTTT GGCGGGGGCC GAGGTCGAGG CGGAGGCTTT 
AGAGGTCGTG GACGAGGAGG AGGTGGAGGC GGCGGCGGCG GTGGAGGAGG AGGAAGAGGT 
GGTGGAGGCT TCCATTCTGG TGGCAACCGG GGTCGTGGTC GGGGAGGAAA AAGAGGAAAC 
CAGTCGGGGA AGAATGTGAT GGTGGAGCCG CATCGGCATG AGGGTGTCTT CATTTGTCGA 
GGAAAGGAAG ATGCACTGGT CACCAAGAAC CTGGTCCCTG GGGAATCAGT TTATGGAGAG 
AAGAGAGTCT CGATTTCGGA AGGAGATGAC AAAATTGAGT ACCGAGCCTG GAACCCCTTC 
CGCTCCAAGC TAGCAGCAGC AATCCTGGGT GGTGTGGACC AGATCCACAT CAAACCGGGG 
GCTAAGGTTC TCTACCTCGG GGCTGCCTCG GGCACCACGG TCTCCCATGT CTCTGACATC 
GTTGGTCCGG ATGGTCTAGT CTATGCAGTC GAGTTCTCCC ACCGCTCTGG CCGTGACCTC 
ATTAACTTGG CCAAGAAGAG GACCAACATC ATTCCTGTGA TCGAGGATGC TCGACACCCA 
CACAAATACC GCATGCTCAT CGCAATGGTG GATGTGATCT TTGCTGATGT GGCCCAGCCA 
GACCAGACCC GGATTGTGGC CCTGAATGCC CACACCTTCC TGCGTAATGG AGGACACTTT 
GTGATTTCCA TTAAGGCCAA CTGCATTGAC TCCACAGCCT CAGCCGAGGC CGTGTTTGCC 
TCCGAAGTGA AAAAGATGCA ACAGGAGAAC ATGAAGCCGC AGGAGCAGTT GACCCTTGAG 
CCATATGAAA GAGACCATGC CGTGGTCGTG GGAGTGTACA GGCCACCCCC CAAGGTGAAG 
AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001427.2
CDS	115..1080
Translation	MKPGFSPRGGGFGGRGGFGDRGGRGGRGGFGGGRGRGGGFRGRGRGGGGGGGGGGGGGRGGGGFHSGGNRGRGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN

Target ORF information:

RefSeq Version	NM_001436.3
Organism	Homo sapiens(human)
Definition	Homo sapiens fibrillarin (FBL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001436.3

ORF Insert Sequence:

ATGAAGCCAG GATTCAGTCC CCGTGGGGGT GGCTTTGGCG GCCGAGGGGG CTTTGGTGAC 
CGTGGTGGTC GTGGAGGCCG AGGGGGCTTT GGCGGGGGCC GAGGTCGAGG CGGAGGCTTT 
AGAGGTCGTG GACGAGGAGG AGGTGGAGGC GGCGGCGGCG GTGGAGGAGG AGGAAGAGGT 
GGTGGAGGCT TCCATTCTGG TGGCAACCGG GGTCGTGGTC GGGGAGGAAA AAGAGGAAAC 
CAGTCGGGGA AGAATGTGAT GGTGGAGCCG CATCGGCATG AGGGTGTCTT CATTTGTCGA 
GGAAAGGAAG ATGCACTGGT CACCAAGAAC CTGGTCCCTG GGGAATCAGT TTATGGAGAG 
AAGAGAGTCT CGATTTCGGA AGGAGATGAC AAAATTGAGT ACCGAGCCTG GAACCCCTTC 
CGCTCCAAGC TAGCAGCAGC AATCCTGGGT GGTGTGGACC AGATCCACAT CAAACCGGGG 
GCTAAGGTTC TCTACCTCGG GGCTGCCTCG GGCACCACGG TCTCCCATGT CTCTGACATC 
GTTGGTCCGG ATGGTCTAGT CTATGCAGTC GAGTTCTCCC ACCGCTCTGG CCGTGACCTC 
ATTAACTTGG CCAAGAAGAG GACCAACATC ATTCCTGTGA TCGAGGATGC TCGACACCCA 
CACAAATACC GCATGCTCAT CGCAATGGTG GATGTGATCT TTGCTGATGT GGCCCAGCCA 
GACCAGACCC GGATTGTGGC CCTGAATGCC CACACCTTCC TGCGTAATGG AGGACACTTT 
GTGATTTCCA TTAAGGCCAA CTGCATTGAC TCCACAGCCT CAGCCGAGGC CGTGTTTGCC 
TCCGAAGTGA AAAAGATGCA ACAGGAGAAC ATGAAGCCGC AGGAGCAGTT GACCCTTGAG 
CCATATGAAA GAGACCATGC CGTGGTCGTG GGAGTGTACA GGCCACCCCC CAAGGTGAAG 
AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBL ( NM_001436.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001427.2 Homo sapiens fibrillarin (FBL), mRNA.

Price & Availability↑

CloneID	OHu02938
Clone ID Related Accession (Same CDS sequence)	NM_001436.3 , NM_001436.4
Accession Version	NM_001436.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 966bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	rRNA 2'-O-methyltransferase fibrillarin
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG831506.1 and BC019260.1. On Nov 22, 2018 this sequence version replaced NM_001436.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC019260.1, SRR1163658.428476.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000221801.8/ ENSP00000221801.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAAGCCAG GATTCAGTCC CCGTGGGGGT GGCTTTGGCG GCCGAGGGGG CTTTGGTGAC 
CGTGGTGGTC GTGGAGGCCG AGGGGGCTTT GGCGGGGGCC GAGGTCGAGG CGGAGGCTTT 
AGAGGTCGTG GACGAGGAGG AGGTGGAGGC GGCGGCGGCG GTGGAGGAGG AGGAAGAGGT 
GGTGGAGGCT TCCATTCTGG TGGCAACCGG GGTCGTGGTC GGGGAGGAAA AAGAGGAAAC 
CAGTCGGGGA AGAATGTGAT GGTGGAGCCG CATCGGCATG AGGGTGTCTT CATTTGTCGA 
GGAAAGGAAG ATGCACTGGT CACCAAGAAC CTGGTCCCTG GGGAATCAGT TTATGGAGAG 
AAGAGAGTCT CGATTTCGGA AGGAGATGAC AAAATTGAGT ACCGAGCCTG GAACCCCTTC 
CGCTCCAAGC TAGCAGCAGC AATCCTGGGT GGTGTGGACC AGATCCACAT CAAACCGGGG 
GCTAAGGTTC TCTACCTCGG GGCTGCCTCG GGCACCACGG TCTCCCATGT CTCTGACATC 
GTTGGTCCGG ATGGTCTAGT CTATGCAGTC GAGTTCTCCC ACCGCTCTGG CCGTGACCTC 
ATTAACTTGG CCAAGAAGAG GACCAACATC ATTCCTGTGA TCGAGGATGC TCGACACCCA 
CACAAATACC GCATGCTCAT CGCAATGGTG GATGTGATCT TTGCTGATGT GGCCCAGCCA 
GACCAGACCC GGATTGTGGC CCTGAATGCC CACACCTTCC TGCGTAATGG AGGACACTTT 
GTGATTTCCA TTAAGGCCAA CTGCATTGAC TCCACAGCCT CAGCCGAGGC CGTGTTTGCC 
TCCGAAGTGA AAAAGATGCA ACAGGAGAAC ATGAAGCCGC AGGAGCAGTT GACCCTTGAG 
CCATATGAAA GAGACCATGC CGTGGTCGTG GGAGTGTACA GGCCACCCCC CAAGGTGAAG 
AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001427.2
CDS	80..1045
Translation	MKPGFSPRGGGFGGRGGFGDRGGRGGRGGFGGGRGRGGGFRGRGRGGGGGGGGGGGGGRGGGGFHSGGNRGRGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN

Target ORF information:

RefSeq Version	NM_001436.4
Organism	Homo sapiens(human)
Definition	Homo sapiens fibrillarin (FBL), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001436.4

ORF Insert Sequence:

ATGAAGCCAG GATTCAGTCC CCGTGGGGGT GGCTTTGGCG GCCGAGGGGG CTTTGGTGAC 
CGTGGTGGTC GTGGAGGCCG AGGGGGCTTT GGCGGGGGCC GAGGTCGAGG CGGAGGCTTT 
AGAGGTCGTG GACGAGGAGG AGGTGGAGGC GGCGGCGGCG GTGGAGGAGG AGGAAGAGGT 
GGTGGAGGCT TCCATTCTGG TGGCAACCGG GGTCGTGGTC GGGGAGGAAA AAGAGGAAAC 
CAGTCGGGGA AGAATGTGAT GGTGGAGCCG CATCGGCATG AGGGTGTCTT CATTTGTCGA 
GGAAAGGAAG ATGCACTGGT CACCAAGAAC CTGGTCCCTG GGGAATCAGT TTATGGAGAG 
AAGAGAGTCT CGATTTCGGA AGGAGATGAC AAAATTGAGT ACCGAGCCTG GAACCCCTTC 
CGCTCCAAGC TAGCAGCAGC AATCCTGGGT GGTGTGGACC AGATCCACAT CAAACCGGGG 
GCTAAGGTTC TCTACCTCGG GGCTGCCTCG GGCACCACGG TCTCCCATGT CTCTGACATC 
GTTGGTCCGG ATGGTCTAGT CTATGCAGTC GAGTTCTCCC ACCGCTCTGG CCGTGACCTC 
ATTAACTTGG CCAAGAAGAG GACCAACATC ATTCCTGTGA TCGAGGATGC TCGACACCCA 
CACAAATACC GCATGCTCAT CGCAATGGTG GATGTGATCT TTGCTGATGT GGCCCAGCCA 
GACCAGACCC GGATTGTGGC CCTGAATGCC CACACCTTCC TGCGTAATGG AGGACACTTT 
GTGATTTCCA TTAAGGCCAA CTGCATTGAC TCCACAGCCT CAGCCGAGGC CGTGTTTGCC 
TCCGAAGTGA AAAAGATGCA ACAGGAGAAC ATGAAGCCGC AGGAGCAGTT GACCCTTGAG 
CCATATGAAA GAGACCATGC CGTGGTCGTG GGAGTGTACA GGCCACCCCC CAAGGTGAAG 
AACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBL ( XM_005258651.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_005258708.1 Homo sapiens fibrillarin (FBL), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu52106
Clone ID Related Accession (Same CDS sequence)	XM_005258651.2
Accession Version	XM_005258651.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 963bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rRNA 2'-O-methyltransferase fibrillarin isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 12, 2015 this sequence version replaced XM_005258651.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCCAG GATTCAGTCC CCGTGGGGGT GGCTTTGGCG GCCGAGGGGG CTTTGGTGAC 
CGTGGTGGTC GTGGAGGCCG AGGGGGCTTT GGCGGGGGCC GAGGTCGAGG CGGAGGCTTT 
AGAGGTCGTG GACGAGGAGG AGGTGGAGGC GGCGGCGGCG GTGGAGGAGG AGGAAGAGGT 
GGAGGCTTCC ATTCTGGTGG CAACCGGGGT CGTGGTCGGG GAGGAAAAAG AGGAAACCAG 
TCGGGGAAGA ATGTGATGGT GGAGCCGCAT CGGCATGAGG GTGTCTTCAT TTGTCGAGGA 
AAGGAAGATG CACTGGTCAC CAAGAACCTG GTCCCTGGGG AATCAGTTTA TGGAGAGAAG 
AGAGTCTCGA TTTCGGAAGG AGATGACAAA ATTGAGTACC GAGCCTGGAA CCCCTTCCGC 
TCCAAGCTAG CAGCAGCAAT CCTGGGTGGT GTGGACCAGA TCCACATCAA ACCGGGGGCT 
AAGGTTCTCT ACCTCGGGGC TGCCTCGGGC ACCACGGTCT CCCATGTCTC TGACATCGTT 
GGTCCGGATG GTCTAGTCTA TGCAGTCGAG TTCTCCCACC GCTCTGGCCG TGACCTCATT 
AACTTGGCCA AGAAGAGGAC CAACATCATT CCTGTGATCG AGGATGCTCG ACACCCACAC 
AAATACCGCA TGCTCATCGC AATGGTGGAT GTGATCTTTG CTGATGTGGC CCAGCCAGAC 
CAGACCCGGA TTGTGGCCCT GAATGCCCAC ACCTTCCTGC GTAATGGAGG ACACTTTGTG 
ATTTCCATTA AGGCCAACTG CATTGACTCC ACAGCCTCAG CCGAGGCCGT GTTTGCCTCC 
GAAGTGAAAA AGATGCAACA GGAGAACATG AAGCCGCAGG AGCAGTTGAC CCTTGAGCCA 
TATGAAAGAG ACCATGCCGT GGTCGTGGGA GTGTACAGGC CACCCCCCAA GGTGAAGAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005258708.1
CDS	96..1058
Translation	MKPGFSPRGGGFGGRGGFGDRGGRGGRGGFGGGRGRGGGFRGRGRGGGGGGGGGGGGGRGGGFHSGGNRGRGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN

Target ORF information:

RefSeq Version	XM_005258651.2
Organism	Homo sapiens(human)
Definition	Homo sapiens fibrillarin (FBL), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005258651.2

ORF Insert Sequence:

ATGAAGCCAG GATTCAGTCC CCGTGGGGGT GGCTTTGGCG GCCGAGGGGG CTTTGGTGAC 
CGTGGTGGTC GTGGAGGCCG AGGGGGCTTT GGCGGGGGCC GAGGTCGAGG CGGAGGCTTT 
AGAGGTCGTG GACGAGGAGG AGGTGGAGGC GGCGGCGGCG GTGGAGGAGG AGGAAGAGGT 
GGAGGCTTCC ATTCTGGTGG CAACCGGGGT CGTGGTCGGG GAGGAAAAAG AGGAAACCAG 
TCGGGGAAGA ATGTGATGGT GGAGCCGCAT CGGCATGAGG GTGTCTTCAT TTGTCGAGGA 
AAGGAAGATG CACTGGTCAC CAAGAACCTG GTCCCTGGGG AATCAGTTTA TGGAGAGAAG 
AGAGTCTCGA TTTCGGAAGG AGATGACAAA ATTGAGTACC GAGCCTGGAA CCCCTTCCGC 
TCCAAGCTAG CAGCAGCAAT CCTGGGTGGT GTGGACCAGA TCCACATCAA ACCGGGGGCT 
AAGGTTCTCT ACCTCGGGGC TGCCTCGGGC ACCACGGTCT CCCATGTCTC TGACATCGTT 
GGTCCGGATG GTCTAGTCTA TGCAGTCGAG TTCTCCCACC GCTCTGGCCG TGACCTCATT 
AACTTGGCCA AGAAGAGGAC CAACATCATT CCTGTGATCG AGGATGCTCG ACACCCACAC 
AAATACCGCA TGCTCATCGC AATGGTGGAT GTGATCTTTG CTGATGTGGC CCAGCCAGAC 
CAGACCCGGA TTGTGGCCCT GAATGCCCAC ACCTTCCTGC GTAATGGAGG ACACTTTGTG 
ATTTCCATTA AGGCCAACTG CATTGACTCC ACAGCCTCAG CCGAGGCCGT GTTTGCCTCC 
GAAGTGAAAA AGATGCAACA GGAGAACATG AAGCCGCAGG AGCAGTTGAC CCTTGAGCCA 
TATGAAAGAG ACCATGCCGT GGTCGTGGGA GTGTACAGGC CACCCCCCAA GGTGAAGAAC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBL ( XM_011526623.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524925.1 Homo sapiens fibrillarin (FBL), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu57575
Clone ID Related Accession (Same CDS sequence)	XM_011526623.2
Accession Version	XM_011526623.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 795bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	rRNA 2'-O-methyltransferase fibrillarin isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011526623.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAAGCCAG GTGGAGGCTT CCATTCTGGT GGCAACCGGG GTCGTGGTCG GGGAGGAAAA 
AGAGGAAACC AGTCGGGGAA GAATGTGATG GTGGAGCCGC ATCGGCATGA GGGTGTCTTC 
ATTTGTCGAG GAAAGGAAGA TGCACTGGTC ACCAAGAACC TGGTCCCTGG GGAATCAGTT 
TATGGAGAGA AGAGAGTCTC GATTTCGGAA GGAGATGACA AAATTGAGTA CCGAGCCTGG 
AACCCCTTCC GCTCCAAGCT AGCAGCAGCA ATCCTGGGTG GTGTGGACCA GATCCACATC 
AAACCGGGGG CTAAGGTTCT CTACCTCGGG GCTGCCTCGG GCACCACGGT CTCCCATGTC 
TCTGACATCG TTGGTCCGGA TGGTCTAGTC TATGCAGTCG AGTTCTCCCA CCGCTCTGGC 
CGTGACCTCA TTAACTTGGC CAAGAAGAGG ACCAACATCA TTCCTGTGAT CGAGGATGCT 
CGACACCCAC ACAAATACCG CATGCTCATC GCAATGGTGG ATGTGATCTT TGCTGATGTG 
GCCCAGCCAG ACCAGACCCG GATTGTGGCC CTGAATGCCC ACACCTTCCT GCGTAATGGA 
GGACACTTTG TGATTTCCAT TAAGGCCAAC TGCATTGACT CCACAGCCTC AGCCGAGGCC 
GTGTTTGCCT CCGAAGTGAA AAAGATGCAA CAGGAGAACA TGAAGCCGCA GGAGCAGTTG 
ACCCTTGAGC CATATGAAAG AGACCATGCC GTGGTCGTGG GAGTGTACAG GCCACCCCCC 
AAGGTGAAGA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524925.1
CDS	67..861
Translation	MKPGGGFHSGGNRGRGRGGKRGNQSGKNVMVEPHRHEGVFICRGKEDALVTKNLVPGESVYGEKRVSISEGDDKIEYRAWNPFRSKLAAAILGGVDQIHIKPGAKVLYLGAASGTTVSHVSDIVGPDGLVYAVEFSHRSGRDLINLAKKRTNIIPVIEDARHPHKYRMLIAMVDVIFADVAQPDQTRIVALNAHTFLRNGGHFVISIKANCIDSTASAEAVFASEVKKMQQENMKPQEQLTLEPYERDHAVVVGVYRPPPKVKN

Target ORF information:

RefSeq Version	XM_011526623.2
Organism	Homo sapiens(human)
Definition	Homo sapiens fibrillarin (FBL), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011526623.2

ORF Insert Sequence:

ATGAAGCCAG GTGGAGGCTT CCATTCTGGT GGCAACCGGG GTCGTGGTCG GGGAGGAAAA 
AGAGGAAACC AGTCGGGGAA GAATGTGATG GTGGAGCCGC ATCGGCATGA GGGTGTCTTC 
ATTTGTCGAG GAAAGGAAGA TGCACTGGTC ACCAAGAACC TGGTCCCTGG GGAATCAGTT 
TATGGAGAGA AGAGAGTCTC GATTTCGGAA GGAGATGACA AAATTGAGTA CCGAGCCTGG 
AACCCCTTCC GCTCCAAGCT AGCAGCAGCA ATCCTGGGTG GTGTGGACCA GATCCACATC 
AAACCGGGGG CTAAGGTTCT CTACCTCGGG GCTGCCTCGG GCACCACGGT CTCCCATGTC 
TCTGACATCG TTGGTCCGGA TGGTCTAGTC TATGCAGTCG AGTTCTCCCA CCGCTCTGGC 
CGTGACCTCA TTAACTTGGC CAAGAAGAGG ACCAACATCA TTCCTGTGAT CGAGGATGCT 
CGACACCCAC ACAAATACCG CATGCTCATC GCAATGGTGG ATGTGATCTT TGCTGATGTG 
GCCCAGCCAG ACCAGACCCG GATTGTGGCC CTGAATGCCC ACACCTTCCT GCGTAATGGA 
GGACACTTTG TGATTTCCAT TAAGGCCAAC TGCATTGACT CCACAGCCTC AGCCGAGGCC 
GTGTTTGCCT CCGAAGTGAA AAAGATGCAA CAGGAGAACA TGAAGCCGCA GGAGCAGTTG 
ACCCTTGAGC CATATGAAAG AGACCATGCC GTGGTCGTGG GAGTGTACAG GCCACCCCCC 
AAGGTGAAGA ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Architecture of the human interactome defines protein communities and disease networks.
Nature545(7655)505-509(2017 05)
Huttlin EL,Bruckner RJ,Paulo JA,Cannon JR,Ting L,Baltier K,Colby G,Gebreab F,Gygi MP,Parzen H,Szpyt J,Tam S,Zarraga G,Pontano-Vaites L,Swarup S,White AE,Schweppe DK,Rad R,Erickson BK,Obar RA,Guruharsha KG,Li K,Artavanis-Tsakonas S,Gygi SP,Harper JW

Nucleolar Methyltransferase Fibrillarin: Evolution of Structure and Functions.
Biochemistry. Biokhimiia81(9)941-50(2016 Sep)
Shubina MY,Musinova YR,Sheval EV

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FBL cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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