C9orf72 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	C9orf72
Entrez Gene ID	203228
Full Name	chromosome 9 open reading frame 72
Synonyms	ALSFTD,DENNL72,FTDALS,FTDALS1
General protein information	Preferred Names chromosome 9 open reading frame 72 Names guanine nucleotide exchange C9orf72 protein C9orf72
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p21.2
Summary	The protein encoded by this gene plays an important role in the regulation of endosomal trafficking, and has been shown to interact with Rab proteins that are involved in autophagy and endocytic transport. Expansion of a GGGGCC repeat from 2-22 copies to 700-1600 copies in the intronic sequence between alternate 5' exons in transcripts from this gene is associated with 9p-linked ALS (amyotrophic lateral sclerosis) and FTD (frontotemporal dementia) (PMID: 21944778, 21944779). Studies suggest that hexanucleotide expansions could result in the selective stabilization of repeat-containing pre-mRNA, and the accumulation of insoluble dipeptide repeat protein aggregates that could be pathogenic in FTD-ALS patients (PMID: 23393093). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2016].
Disorder MIM:	614260
Disorder Html:	Frontotemporal dementia and/or amyotrophic lateral sclerosis 1, 105550 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_145005.6	NP_659442.2	guanine nucleotide exchange C9orf72 isoform b
NM_018325.4	NP_060795.1	guanine nucleotide exchange C9orf72 isoform a
NM_018325.5	NP_060795.1	guanine nucleotide exchange C9orf72 isoform a
NM_001256054.2	NP_001242983.1	guanine nucleotide exchange C9orf72 isoform a

Pathways from BioSystems

Homologies

Gallus gallus (chicken)	C9ORF72	XP_424945.2
Homo sapiens (human)	C9orf72	NP_001242983.1
	C15H9orf72	XP_002800118.1
Pan troglodytes (chimpanzee)	C9H9orf72	XP_003951454.1
Canis lupus familiaris (dog)	C11H9orf72	XP_005626755.1
Bos taurus (cattle)	C8H9orf72	NP_001096558.1
Rattus norvegicus (Norway rat)	RGD1359108	NP_001007703.1
Mus musculus (house mouse)	3110043O21Rik	NP_001074812.1
Danio rerio (zebrafish)	zgc:100846	NP_991166.1

Gene Ontology

The following C9orf72 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the C9orf72 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22712	NM_145005.6 Latest version!	Homo sapiens C9orf72-SMCR8 complex subunit (C9orf72), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu23067	NM_018325.5 Latest version!	Homo sapiens C9orf72-SMCR8 complex subunit (C9orf72), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
OHu23067	NM_001256054.2 Latest version!	Homo sapiens C9orf72-SMCR8 complex subunit (C9orf72), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
View Old Accession Versions >>
OHu23067	NM_018325.4	Homo sapiens C9orf72-SMCR8 complex subunit (C9orf72), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

C9orf72 ( NM_145005.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_659442.2 Homo sapiens C9orf72-SMCR8 complex subunit (C9orf72), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22712
Clone ID Related Accession (Same CDS sequence)	NM_145005.6
Accession Version	NM_145005.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 669bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	guanine nucleotide exchange C9orf72 isoform b
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ068108.1, AK057806.1, BC020851.2, DA802421.1 and AI141996.1. On Feb 7, 2015 this sequence version replaced NM_145005.5. Transcript Variant: This variant (1) lacks multiple exons in the central and 3' coding regions, and its 3' terminal exon extends beyond a splice site that is used in variant 3 . This results in a novel 3' UTR, compared to variant 3. It encodes isoform b which is significantly shorter, and its C-terminal amino acid is distinct, compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK057806.1, SRR1803613.329188.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGACTC TTTGCCCACC GCCATCTCCA GCTGTTGCCA AGACAGAGAT TGCTTTAAGT 
GGCAAATCAC CTTTATTAGC AGCTACTTTT GCTTACTGGG ACAATATTCT TGGTCCTAGA 
GTAAGGCACA TTTGGGCTCC AAAGACAGAA CAGGTACTTC TCAGTGATGG AGAAATAACT 
TTTCTTGCCA ACCACACTCT AAATGGAGAA ATCCTTCGAA ATGCAGAGAG TGGTGCTATA 
GATGTAAAGT TTTTTGTCTT GTCTGAAAAG GGAGTGATTA TTGTTTCATT AATCTTTGAT 
GGAAACTGGA ATGGGGATCG CAGCACATAT GGACTATCAA TTATACTTCC ACAGACAGAA 
CTTAGTTTCT ACCTCCCACT TCATAGAGTG TGTGTTGATA GATTAACACA TATAATCCGG 
AAAGGAAGAA TATGGATGCA TAAGGAAAGA CAAGAAAATG TCCAGAAGAT TATCTTAGAA 
GGCACAGAGA GAATGGAAGA TCAGGGTCAG AGTATTATTC CAATGCTTAC TGGAGAAGTG 
ATTCCTGTAA TGGAACTGCT TTCATCTATG AAATCACACA GTGTTCCTGA AGAAATAGAT 
ATAGCTGATA CAGTACTCAA TGATGATGAT ATTGGTGACA GCTGTCATGA AGGCTTTCTT 
CTCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_659442.2
CDS	125..793
Translation	MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVCVDRLTHIIRKGRIWMHKERQENVQKIILEGTERMEDQGQSIIPMLTGEVIPVMELLSSMKSHSVPEEIDIADTVLNDDDIGDSCHEGFLLK

Target ORF information:

RefSeq Version	NM_145005.6
Organism	Homo sapiens(human)
Definition	Homo sapiens C9orf72-SMCR8 complex subunit (C9orf72), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_145005.6

ORF Insert Sequence:

ATGTCGACTC TTTGCCCACC GCCATCTCCA GCTGTTGCCA AGACAGAGAT TGCTTTAAGT 
GGCAAATCAC CTTTATTAGC AGCTACTTTT GCTTACTGGG ACAATATTCT TGGTCCTAGA 
GTAAGGCACA TTTGGGCTCC AAAGACAGAA CAGGTACTTC TCAGTGATGG AGAAATAACT 
TTTCTTGCCA ACCACACTCT AAATGGAGAA ATCCTTCGAA ATGCAGAGAG TGGTGCTATA 
GATGTAAAGT TTTTTGTCTT GTCTGAAAAG GGAGTGATTA TTGTTTCATT AATCTTTGAT 
GGAAACTGGA ATGGGGATCG CAGCACATAT GGACTATCAA TTATACTTCC ACAGACAGAA 
CTTAGTTTCT ACCTCCCACT TCATAGAGTG TGTGTTGATA GATTAACACA TATAATCCGG 
AAAGGAAGAA TATGGATGCA TAAGGAAAGA CAAGAAAATG TCCAGAAGAT TATCTTAGAA 
GGCACAGAGA GAATGGAAGA TCAGGGTCAG AGTATTATTC CAATGCTTAC TGGAGAAGTG 
ATTCCTGTAA TGGAACTGCT TTCATCTATG AAATCACACA GTGTTCCTGA AGAAATAGAT 
ATAGCTGATA CAGTACTCAA TGATGATGAT ATTGGTGACA GCTGTCATGA AGGCTTTCTT 
CTCAAGTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C9orf72 ( NM_018325.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_060795.1 Homo sapiens C9orf72-SMCR8 complex subunit (C9orf72), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23067
Clone ID Related Accession (Same CDS sequence)	NM_018325.4 , NM_018325.5 , NM_001256054.2
Accession Version	NM_018325.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Homo sapiens(human)
Product	guanine nucleotide exchange C9orf72 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BG718065.1, AK291425.1, BC068445.1, BC020851.2, BC039112.1, BQ777139.1 and AL832229.1. On Feb 7, 2015 this sequence version replaced NM_018325.3. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Both variants 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL832229.1, SRR1660805.35476.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGACTC TTTGCCCACC GCCATCTCCA GCTGTTGCCA AGACAGAGAT TGCTTTAAGT 
GGCAAATCAC CTTTATTAGC AGCTACTTTT GCTTACTGGG ACAATATTCT TGGTCCTAGA 
GTAAGGCACA TTTGGGCTCC AAAGACAGAA CAGGTACTTC TCAGTGATGG AGAAATAACT 
TTTCTTGCCA ACCACACTCT AAATGGAGAA ATCCTTCGAA ATGCAGAGAG TGGTGCTATA 
GATGTAAAGT TTTTTGTCTT GTCTGAAAAG GGAGTGATTA TTGTTTCATT AATCTTTGAT 
GGAAACTGGA ATGGGGATCG CAGCACATAT GGACTATCAA TTATACTTCC ACAGACAGAA 
CTTAGTTTCT ACCTCCCACT TCATAGAGTG TGTGTTGATA GATTAACACA TATAATCCGG 
AAAGGAAGAA TATGGATGCA TAAGGAAAGA CAAGAAAATG TCCAGAAGAT TATCTTAGAA 
GGCACAGAGA GAATGGAAGA TCAGGGTCAG AGTATTATTC CAATGCTTAC TGGAGAAGTG 
ATTCCTGTAA TGGAACTGCT TTCATCTATG AAATCACACA GTGTTCCTGA AGAAATAGAT 
ATAGCTGATA CAGTACTCAA TGATGATGAT ATTGGTGACA GCTGTCATGA AGGCTTTCTT 
CTCAATGCCA TCAGCTCACA CTTGCAAACC TGTGGCTGTT CCGTTGTAGT AGGTAGCAGT 
GCAGAGAAAG TAAATAAGAT AGTCAGAACA TTATGCCTTT TTCTGACTCC AGCAGAGAGA 
AAATGCTCCA GGTTATGTGA AGCAGAATCA TCATTTAAAT ATGAGTCAGG GCTCTTTGTA 
CAAGGCCTGC TAAAGGATTC AACTGGAAGC TTTGTGCTGC CTTTCCGGCA AGTCATGTAT 
GCTCCATATC CCACCACACA CATAGATGTG GATGTCAATA CTGTGAAGCA GATGCCACCC 
TGTCATGAAC ATATTTATAA TCAGCGTAGA TACATGAGAT CCGAGCTGAC AGCCTTCTGG 
AGAGCCACTT CAGAAGAAGA CATGGCTCAG GATACGATCA TCTACACTGA CGAAAGCTTT 
ACTCCTGATT TGAATATTTT TCAAGATGTC TTACACAGAG ACACTCTAGT GAAAGCCTTC 
CTGGATCAGG TCTTTCAGCT GAAACCTGGC TTATCTCTCA GAAGTACTTT CCTTGCACAG 
TTTCTACTTG TCCTTCACAG AAAAGCCTTG ACACTAATAA AATATATAGA AGACGATACG 
CAGAAGGGAA AAAAGCCCTT TAAATCTCTT CGGAACCTGA AGATAGACCT TGATTTAACA 
GCAGAGGGCG ATCTTAACAT AATAATGGCT CTGGCTGAGA AAATTAAACC AGGCCTACAC 
TCTTTTATCT TTGGAAGACC TTTCTACACT AGTGTGCAAG AACGAGATGT TCTAATGACT 
TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060795.1
CDS	108..1553
Translation	MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVCVDRLTHIIRKGRIWMHKERQENVQKIILEGTERMEDQGQSIIPMLTGEVIPVMELLSSMKSHSVPEEIDIADTVLNDDDIGDSCHEGFLLNAISSHLQTCGCSVVVGSSAEKVNKIVRTLCLFLTPAERKCSRLCEAESSFKYESGLFVQGLLKDSTGSFVLPFRQVMYAPYPTTHIDVDVNTVKQMPPCHEHIYNQRRYMRSELTAFWRATSEEDMAQDTIIYTDESFTPDLNIFQDVLHRDTLVKAFLDQVFQLKPGLSLRSTFLAQFLLVLHRKALTLIKYIEDDTQKGKKPFKSLRNLKIDLDLTAEGDLNIIMALAEKIKPGLHSFIFGRPFYTSVQERDVLMTF

Target ORF information:

RefSeq Version	NM_018325.4
Organism	Homo sapiens(human)
Definition	Homo sapiens C9orf72-SMCR8 complex subunit (C9orf72), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018325.4

ORF Insert Sequence:

ATGTCGACTC TTTGCCCACC GCCATCTCCA GCTGTTGCCA AGACAGAGAT TGCTTTAAGT 
GGCAAATCAC CTTTATTAGC AGCTACTTTT GCTTACTGGG ACAATATTCT TGGTCCTAGA 
GTAAGGCACA TTTGGGCTCC AAAGACAGAA CAGGTACTTC TCAGTGATGG AGAAATAACT 
TTTCTTGCCA ACCACACTCT AAATGGAGAA ATCCTTCGAA ATGCAGAGAG TGGTGCTATA 
GATGTAAAGT TTTTTGTCTT GTCTGAAAAG GGAGTGATTA TTGTTTCATT AATCTTTGAT 
GGAAACTGGA ATGGGGATCG CAGCACATAT GGACTATCAA TTATACTTCC ACAGACAGAA 
CTTAGTTTCT ACCTCCCACT TCATAGAGTG TGTGTTGATA GATTAACACA TATAATCCGG 
AAAGGAAGAA TATGGATGCA TAAGGAAAGA CAAGAAAATG TCCAGAAGAT TATCTTAGAA 
GGCACAGAGA GAATGGAAGA TCAGGGTCAG AGTATTATTC CAATGCTTAC TGGAGAAGTG 
ATTCCTGTAA TGGAACTGCT TTCATCTATG AAATCACACA GTGTTCCTGA AGAAATAGAT 
ATAGCTGATA CAGTACTCAA TGATGATGAT ATTGGTGACA GCTGTCATGA AGGCTTTCTT 
CTCAATGCCA TCAGCTCACA CTTGCAAACC TGTGGCTGTT CCGTTGTAGT AGGTAGCAGT 
GCAGAGAAAG TAAATAAGAT AGTCAGAACA TTATGCCTTT TTCTGACTCC AGCAGAGAGA 
AAATGCTCCA GGTTATGTGA AGCAGAATCA TCATTTAAAT ATGAGTCAGG GCTCTTTGTA 
CAAGGCCTGC TAAAGGATTC AACTGGAAGC TTTGTGCTGC CTTTCCGGCA AGTCATGTAT 
GCTCCATATC CCACCACACA CATAGATGTG GATGTCAATA CTGTGAAGCA GATGCCACCC 
TGTCATGAAC ATATTTATAA TCAGCGTAGA TACATGAGAT CCGAGCTGAC AGCCTTCTGG 
AGAGCCACTT CAGAAGAAGA CATGGCTCAG GATACGATCA TCTACACTGA CGAAAGCTTT 
ACTCCTGATT TGAATATTTT TCAAGATGTC TTACACAGAG ACACTCTAGT GAAAGCCTTC 
CTGGATCAGG TCTTTCAGCT GAAACCTGGC TTATCTCTCA GAAGTACTTT CCTTGCACAG 
TTTCTACTTG TCCTTCACAG AAAAGCCTTG ACACTAATAA AATATATAGA AGACGATACG 
CAGAAGGGAA AAAAGCCCTT TAAATCTCTT CGGAACCTGA AGATAGACCT TGATTTAACA 
GCAGAGGGCG ATCTTAACAT AATAATGGCT CTGGCTGAGA AAATTAAACC AGGCCTACAC 
TCTTTTATCT TTGGAAGACC TTTCTACACT AGTGTGCAAG AACGAGATGT TCTAATGACT 
TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C9orf72 ( NM_018325.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_060795.1 Homo sapiens C9orf72-SMCR8 complex subunit (C9orf72), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu23067
Clone ID Related Accession (Same CDS sequence)	NM_018325.4 , NM_018325.5 , NM_001256054.2
Accession Version	NM_018325.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	guanine nucleotide exchange C9orf72 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK291425.1, BC068445.1, BC020851.2, BC039112.1, BQ777139.1 and AL832229.1. On Jun 28, 2019 this sequence version replaced NM_018325.4. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 3. Both variants 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AL832229.1, SRR1660807.249254.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCGACTC TTTGCCCACC GCCATCTCCA GCTGTTGCCA AGACAGAGAT TGCTTTAAGT 
GGCAAATCAC CTTTATTAGC AGCTACTTTT GCTTACTGGG ACAATATTCT TGGTCCTAGA 
GTAAGGCACA TTTGGGCTCC AAAGACAGAA CAGGTACTTC TCAGTGATGG AGAAATAACT 
TTTCTTGCCA ACCACACTCT AAATGGAGAA ATCCTTCGAA ATGCAGAGAG TGGTGCTATA 
GATGTAAAGT TTTTTGTCTT GTCTGAAAAG GGAGTGATTA TTGTTTCATT AATCTTTGAT 
GGAAACTGGA ATGGGGATCG CAGCACATAT GGACTATCAA TTATACTTCC ACAGACAGAA 
CTTAGTTTCT ACCTCCCACT TCATAGAGTG TGTGTTGATA GATTAACACA TATAATCCGG 
AAAGGAAGAA TATGGATGCA TAAGGAAAGA CAAGAAAATG TCCAGAAGAT TATCTTAGAA 
GGCACAGAGA GAATGGAAGA TCAGGGTCAG AGTATTATTC CAATGCTTAC TGGAGAAGTG 
ATTCCTGTAA TGGAACTGCT TTCATCTATG AAATCACACA GTGTTCCTGA AGAAATAGAT 
ATAGCTGATA CAGTACTCAA TGATGATGAT ATTGGTGACA GCTGTCATGA AGGCTTTCTT 
CTCAATGCCA TCAGCTCACA CTTGCAAACC TGTGGCTGTT CCGTTGTAGT AGGTAGCAGT 
GCAGAGAAAG TAAATAAGAT AGTCAGAACA TTATGCCTTT TTCTGACTCC AGCAGAGAGA 
AAATGCTCCA GGTTATGTGA AGCAGAATCA TCATTTAAAT ATGAGTCAGG GCTCTTTGTA 
CAAGGCCTGC TAAAGGATTC AACTGGAAGC TTTGTGCTGC CTTTCCGGCA AGTCATGTAT 
GCTCCATATC CCACCACACA CATAGATGTG GATGTCAATA CTGTGAAGCA GATGCCACCC 
TGTCATGAAC ATATTTATAA TCAGCGTAGA TACATGAGAT CCGAGCTGAC AGCCTTCTGG 
AGAGCCACTT CAGAAGAAGA CATGGCTCAG GATACGATCA TCTACACTGA CGAAAGCTTT 
ACTCCTGATT TGAATATTTT TCAAGATGTC TTACACAGAG ACACTCTAGT GAAAGCCTTC 
CTGGATCAGG TCTTTCAGCT GAAACCTGGC TTATCTCTCA GAAGTACTTT CCTTGCACAG 
TTTCTACTTG TCCTTCACAG AAAAGCCTTG ACACTAATAA AATATATAGA AGACGATACG 
CAGAAGGGAA AAAAGCCCTT TAAATCTCTT CGGAACCTGA AGATAGACCT TGATTTAACA 
GCAGAGGGCG ATCTTAACAT AATAATGGCT CTGGCTGAGA AAATTAAACC AGGCCTACAC 
TCTTTTATCT TTGGAAGACC TTTCTACACT AGTGTGCAAG AACGAGATGT TCTAATGACT 
TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_060795.1
CDS	96..1541
Translation	MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVCVDRLTHIIRKGRIWMHKERQENVQKIILEGTERMEDQGQSIIPMLTGEVIPVMELLSSMKSHSVPEEIDIADTVLNDDDIGDSCHEGFLLNAISSHLQTCGCSVVVGSSAEKVNKIVRTLCLFLTPAERKCSRLCEAESSFKYESGLFVQGLLKDSTGSFVLPFRQVMYAPYPTTHIDVDVNTVKQMPPCHEHIYNQRRYMRSELTAFWRATSEEDMAQDTIIYTDESFTPDLNIFQDVLHRDTLVKAFLDQVFQLKPGLSLRSTFLAQFLLVLHRKALTLIKYIEDDTQKGKKPFKSLRNLKIDLDLTAEGDLNIIMALAEKIKPGLHSFIFGRPFYTSVQERDVLMTF

Target ORF information:

RefSeq Version	NM_018325.5
Organism	Homo sapiens(human)
Definition	Homo sapiens C9orf72-SMCR8 complex subunit (C9orf72), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_018325.5

ORF Insert Sequence:

ATGTCGACTC TTTGCCCACC GCCATCTCCA GCTGTTGCCA AGACAGAGAT TGCTTTAAGT 
GGCAAATCAC CTTTATTAGC AGCTACTTTT GCTTACTGGG ACAATATTCT TGGTCCTAGA 
GTAAGGCACA TTTGGGCTCC AAAGACAGAA CAGGTACTTC TCAGTGATGG AGAAATAACT 
TTTCTTGCCA ACCACACTCT AAATGGAGAA ATCCTTCGAA ATGCAGAGAG TGGTGCTATA 
GATGTAAAGT TTTTTGTCTT GTCTGAAAAG GGAGTGATTA TTGTTTCATT AATCTTTGAT 
GGAAACTGGA ATGGGGATCG CAGCACATAT GGACTATCAA TTATACTTCC ACAGACAGAA 
CTTAGTTTCT ACCTCCCACT TCATAGAGTG TGTGTTGATA GATTAACACA TATAATCCGG 
AAAGGAAGAA TATGGATGCA TAAGGAAAGA CAAGAAAATG TCCAGAAGAT TATCTTAGAA 
GGCACAGAGA GAATGGAAGA TCAGGGTCAG AGTATTATTC CAATGCTTAC TGGAGAAGTG 
ATTCCTGTAA TGGAACTGCT TTCATCTATG AAATCACACA GTGTTCCTGA AGAAATAGAT 
ATAGCTGATA CAGTACTCAA TGATGATGAT ATTGGTGACA GCTGTCATGA AGGCTTTCTT 
CTCAATGCCA TCAGCTCACA CTTGCAAACC TGTGGCTGTT CCGTTGTAGT AGGTAGCAGT 
GCAGAGAAAG TAAATAAGAT AGTCAGAACA TTATGCCTTT TTCTGACTCC AGCAGAGAGA 
AAATGCTCCA GGTTATGTGA AGCAGAATCA TCATTTAAAT ATGAGTCAGG GCTCTTTGTA 
CAAGGCCTGC TAAAGGATTC AACTGGAAGC TTTGTGCTGC CTTTCCGGCA AGTCATGTAT 
GCTCCATATC CCACCACACA CATAGATGTG GATGTCAATA CTGTGAAGCA GATGCCACCC 
TGTCATGAAC ATATTTATAA TCAGCGTAGA TACATGAGAT CCGAGCTGAC AGCCTTCTGG 
AGAGCCACTT CAGAAGAAGA CATGGCTCAG GATACGATCA TCTACACTGA CGAAAGCTTT 
ACTCCTGATT TGAATATTTT TCAAGATGTC TTACACAGAG ACACTCTAGT GAAAGCCTTC 
CTGGATCAGG TCTTTCAGCT GAAACCTGGC TTATCTCTCA GAAGTACTTT CCTTGCACAG 
TTTCTACTTG TCCTTCACAG AAAAGCCTTG ACACTAATAA AATATATAGA AGACGATACG 
CAGAAGGGAA AAAAGCCCTT TAAATCTCTT CGGAACCTGA AGATAGACCT TGATTTAACA 
GCAGAGGGCG ATCTTAACAT AATAATGGCT CTGGCTGAGA AAATTAAACC AGGCCTACAC 
TCTTTTATCT TTGGAAGACC TTTCTACACT AGTGTGCAAG AACGAGATGT TCTAATGACT 
TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

C9orf72 ( NM_001256054.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001242983.1 Homo sapiens C9orf72-SMCR8 complex subunit (C9orf72), transcript variant 3, mRNA.

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CloneID	OHu23067
Clone ID Related Accession (Same CDS sequence)	NM_018325.4 , NM_018325.5 , NM_001256054.2
Accession Version	NM_001256054.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1446bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-25
Organism	Homo sapiens(human)
Product	guanine nucleotide exchange C9orf72 isoform a
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BQ068108.1, JN681271.1 and AL832229.1. This sequence is a reference standard in the RefSeqGene project. On Feb 7, 2015 this sequence version replaced NM_001256054.1. Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (a). Hexanucleotide expansions that can occur in a repeat region between the first and second exon of this variant have been associated with frontotemporal dementia and amyotrophic lateral sclerosis (FTD-ALS;PMID: 21944778, PMID: 21944779 ). Variants 2 and 3 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: JN681271.1, SRR1803611.127062.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGTCGACTC TTTGCCCACC GCCATCTCCA GCTGTTGCCA AGACAGAGAT TGCTTTAAGT 
GGCAAATCAC CTTTATTAGC AGCTACTTTT GCTTACTGGG ACAATATTCT TGGTCCTAGA 
GTAAGGCACA TTTGGGCTCC AAAGACAGAA CAGGTACTTC TCAGTGATGG AGAAATAACT 
TTTCTTGCCA ACCACACTCT AAATGGAGAA ATCCTTCGAA ATGCAGAGAG TGGTGCTATA 
GATGTAAAGT TTTTTGTCTT GTCTGAAAAG GGAGTGATTA TTGTTTCATT AATCTTTGAT 
GGAAACTGGA ATGGGGATCG CAGCACATAT GGACTATCAA TTATACTTCC ACAGACAGAA 
CTTAGTTTCT ACCTCCCACT TCATAGAGTG TGTGTTGATA GATTAACACA TATAATCCGG 
AAAGGAAGAA TATGGATGCA TAAGGAAAGA CAAGAAAATG TCCAGAAGAT TATCTTAGAA 
GGCACAGAGA GAATGGAAGA TCAGGGTCAG AGTATTATTC CAATGCTTAC TGGAGAAGTG 
ATTCCTGTAA TGGAACTGCT TTCATCTATG AAATCACACA GTGTTCCTGA AGAAATAGAT 
ATAGCTGATA CAGTACTCAA TGATGATGAT ATTGGTGACA GCTGTCATGA AGGCTTTCTT 
CTCAATGCCA TCAGCTCACA CTTGCAAACC TGTGGCTGTT CCGTTGTAGT AGGTAGCAGT 
GCAGAGAAAG TAAATAAGAT AGTCAGAACA TTATGCCTTT TTCTGACTCC AGCAGAGAGA 
AAATGCTCCA GGTTATGTGA AGCAGAATCA TCATTTAAAT ATGAGTCAGG GCTCTTTGTA 
CAAGGCCTGC TAAAGGATTC AACTGGAAGC TTTGTGCTGC CTTTCCGGCA AGTCATGTAT 
GCTCCATATC CCACCACACA CATAGATGTG GATGTCAATA CTGTGAAGCA GATGCCACCC 
TGTCATGAAC ATATTTATAA TCAGCGTAGA TACATGAGAT CCGAGCTGAC AGCCTTCTGG 
AGAGCCACTT CAGAAGAAGA CATGGCTCAG GATACGATCA TCTACACTGA CGAAAGCTTT 
ACTCCTGATT TGAATATTTT TCAAGATGTC TTACACAGAG ACACTCTAGT GAAAGCCTTC 
CTGGATCAGG TCTTTCAGCT GAAACCTGGC TTATCTCTCA GAAGTACTTT CCTTGCACAG 
TTTCTACTTG TCCTTCACAG AAAAGCCTTG ACACTAATAA AATATATAGA AGACGATACG 
CAGAAGGGAA AAAAGCCCTT TAAATCTCTT CGGAACCTGA AGATAGACCT TGATTTAACA 
GCAGAGGGCG ATCTTAACAT AATAATGGCT CTGGCTGAGA AAATTAAACC AGGCCTACAC 
TCTTTTATCT TTGGAAGACC TTTCTACACT AGTGTGCAAG AACGAGATGT TCTAATGACT 
TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001242983.1
CDS	203..1648
Translation	MSTLCPPPSPAVAKTEIALSGKSPLLAATFAYWDNILGPRVRHIWAPKTEQVLLSDGEITFLANHTLNGEILRNAESGAIDVKFFVLSEKGVIIVSLIFDGNWNGDRSTYGLSIILPQTELSFYLPLHRVCVDRLTHIIRKGRIWMHKERQENVQKIILEGTERMEDQGQSIIPMLTGEVIPVMELLSSMKSHSVPEEIDIADTVLNDDDIGDSCHEGFLLNAISSHLQTCGCSVVVGSSAEKVNKIVRTLCLFLTPAERKCSRLCEAESSFKYESGLFVQGLLKDSTGSFVLPFRQVMYAPYPTTHIDVDVNTVKQMPPCHEHIYNQRRYMRSELTAFWRATSEEDMAQDTIIYTDESFTPDLNIFQDVLHRDTLVKAFLDQVFQLKPGLSLRSTFLAQFLLVLHRKALTLIKYIEDDTQKGKKPFKSLRNLKIDLDLTAEGDLNIIMALAEKIKPGLHSFIFGRPFYTSVQERDVLMTF

Target ORF information:

RefSeq Version	NM_001256054.2
Organism	Homo sapiens(human)
Definition	Homo sapiens C9orf72-SMCR8 complex subunit (C9orf72), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001256054.2

ORF Insert Sequence:

ATGTCGACTC TTTGCCCACC GCCATCTCCA GCTGTTGCCA AGACAGAGAT TGCTTTAAGT 
GGCAAATCAC CTTTATTAGC AGCTACTTTT GCTTACTGGG ACAATATTCT TGGTCCTAGA 
GTAAGGCACA TTTGGGCTCC AAAGACAGAA CAGGTACTTC TCAGTGATGG AGAAATAACT 
TTTCTTGCCA ACCACACTCT AAATGGAGAA ATCCTTCGAA ATGCAGAGAG TGGTGCTATA 
GATGTAAAGT TTTTTGTCTT GTCTGAAAAG GGAGTGATTA TTGTTTCATT AATCTTTGAT 
GGAAACTGGA ATGGGGATCG CAGCACATAT GGACTATCAA TTATACTTCC ACAGACAGAA 
CTTAGTTTCT ACCTCCCACT TCATAGAGTG TGTGTTGATA GATTAACACA TATAATCCGG 
AAAGGAAGAA TATGGATGCA TAAGGAAAGA CAAGAAAATG TCCAGAAGAT TATCTTAGAA 
GGCACAGAGA GAATGGAAGA TCAGGGTCAG AGTATTATTC CAATGCTTAC TGGAGAAGTG 
ATTCCTGTAA TGGAACTGCT TTCATCTATG AAATCACACA GTGTTCCTGA AGAAATAGAT 
ATAGCTGATA CAGTACTCAA TGATGATGAT ATTGGTGACA GCTGTCATGA AGGCTTTCTT 
CTCAATGCCA TCAGCTCACA CTTGCAAACC TGTGGCTGTT CCGTTGTAGT AGGTAGCAGT 
GCAGAGAAAG TAAATAAGAT AGTCAGAACA TTATGCCTTT TTCTGACTCC AGCAGAGAGA 
AAATGCTCCA GGTTATGTGA AGCAGAATCA TCATTTAAAT ATGAGTCAGG GCTCTTTGTA 
CAAGGCCTGC TAAAGGATTC AACTGGAAGC TTTGTGCTGC CTTTCCGGCA AGTCATGTAT 
GCTCCATATC CCACCACACA CATAGATGTG GATGTCAATA CTGTGAAGCA GATGCCACCC 
TGTCATGAAC ATATTTATAA TCAGCGTAGA TACATGAGAT CCGAGCTGAC AGCCTTCTGG 
AGAGCCACTT CAGAAGAAGA CATGGCTCAG GATACGATCA TCTACACTGA CGAAAGCTTT 
ACTCCTGATT TGAATATTTT TCAAGATGTC TTACACAGAG ACACTCTAGT GAAAGCCTTC 
CTGGATCAGG TCTTTCAGCT GAAACCTGGC TTATCTCTCA GAAGTACTTT CCTTGCACAG 
TTTCTACTTG TCCTTCACAG AAAAGCCTTG ACACTAATAA AATATATAGA AGACGATACG 
CAGAAGGGAA AAAAGCCCTT TAAATCTCTT CGGAACCTGA AGATAGACCT TGATTTAACA 
GCAGAGGGCG ATCTTAACAT AATAATGGCT CTGGCTGAGA AAATTAAACC AGGCCTACAC 
TCTTTTATCT TTGGAAGACC TTTCTACACT AGTGTGCAAG AACGAGATGT TCTAATGACT 
TTTTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

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C9orf72 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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FAX

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