GABRR3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GABRR3
Entrez Gene ID	200959
Full Name	gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene)
General protein information	Preferred Names gamma-aminobutyric acid type A receptor rho3 subunit (gene/pseudogene) Names gamma-aminobutyric acid receptor subunit rho-3 GABA(A) receptor subunit rho-3 GABA(C) receptor gamma-aminobutyric acid (GABA) A receptor, rho 3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q11.2
Summary	The neurotransmitter gamma-aminobutyric acid (GABA) functions in the central nervous system to regulate synaptic transmission of neurons. This gene encodes one of three related subunits, which combine as homo- or hetero-pentamers to form GABA(C) receptors. In humans, some individuals contain a single-base polymorphism (dbSNP rs832032) that is predicted to inactivate the gene product. [provided by RefSeq, Jan 2012].

mRNA and Protein(s)

mRNA	Protein	Name
NM_001105580.2	NP_001099050.1	gamma-aminobutyric acid receptor subunit rho-3 precursor

Pathways from BioSystems

Homologies

	GABRR3	XP_001087158.2
Xenopus tropicalis (tropical clawed frog)	gabrr3	XP_002933116.2
Danio rerio (zebrafish)	gabrr3a	NP_001122232.1
Bos taurus (cattle)	GABRR3	NP_001179448.1
Rattus norvegicus (Norway rat)	Gabrr3	NP_620252.1
Pan troglodytes (chimpanzee)	GABRR3	XP_526252.1
Mus musculus (house mouse)	Gabrr3	NP_001074659.1
Danio rerio (zebrafish)	LOC561083	XP_689576.5
Homo sapiens (human)	GABRR3	NP_001099050.1
Gallus gallus (chicken)	GABRR3	XP_428531.4

Gene Ontology
Bibliography

Related articles in PubMed

Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor.
Garc?a-Mart?n E, Mart?nez C, Alonso-Navarro H, Benito-Le?n J, Lorenzo-Betancor O, Pastor P, Puertas I, Rubio L, L?pez-Alburquerque T, Ag?ndez JA, Jim?nez-Jim?nez FJ
Journal of neurology258(2)203-11(2011 Feb)

Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.
Craddock N, Jones L, Jones IR, Kirov G, Green EK, Grozeva D, Moskvina V, Nikolov I, Hamshere ML, Vukcevic D, Caesar S, Gordon-Smith K, Fraser C, Russell E, Norton N, Breen G, St Clair D, Collier DA, Young AH, Ferrier IN, Farmer A, McGuffin P, Holmans PA, , Donnelly P, Owen MJ, O'Donovan MC
Molecular psychiatry15(2)146-53(2010 Feb)

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
Gratac?s M, Costas J, de Cid R, Bay?s M, Gonz?lez JR, Baca-Garc?a E, de Diego Y, Fern?ndez-Aranda F, Fern?ndez-Piqueras J, Guitart M, Mart?n-Santos R, Martorell L, Mench?n JM, Roca M, S?iz-Ruiz J, Sanju?n J, Torrens M, Urretavizcaya M, Valero J, Vilella E, Estivill X, Carracedo A,
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics150B(6)808-16(2009 Sep)

GABA receptor rho subunit expression in the developing rat brain.
Alakuijala A, Palgi M, Wegelius K, Schmidt M, Enz R, Paulin L, Saarma M, Pasternack M
Brain research. Developmental brain research154(1)15-23(2005 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

found no significant differences in either the frequencies of the GABRR1-M26V, GABRR1- H27R, GABRR2-T455M, and GABRR3-Y205X genotypes or in the frequencies of the allelic variants of these polymorphisms in patients with essential tremor
Title: Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor.

Observational study of gene-disease association. (HuGE Navigator)
Title: Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.

Observational study of gene-disease association. (HuGE Navigator)
Title: Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.

GABA(C) receptors are specifically involved in aspects of visual image motion processing in the rat brain
Title: GABA receptor rho subunit expression in the developing rat brain.

The following GABRR3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GABRR3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu13993	NM_001105580.2 Latest version!	Homo sapiens gamma-aminobutyric acid type A receptor subunit rho3 (gene/pseudogene) (GABRR3), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$272.30 $389.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GABRR3 ( NM_001105580.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001099050.1 Homo sapiens gamma-aminobutyric acid type A receptor subunit rho3 (gene/pseudogene) (GABRR3), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu13993
Clone ID Related Accession (Same CDS sequence)	NM_001105580.2
Accession Version	NM_001105580.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1404bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-26
Organism	Homo sapiens(human)
Product	gamma-aminobutyric acid receptor subunit rho-3 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC026100.19 and KF459624.1. On Aug 2, 2011 this sequence version replaced NM_001105580.1. Transcript Variant: This variant (1) represents the functional allele (SNP rs832032, has Tyr205 versus a stop codon) and encodes the supported protein. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence because no single human transcript was available for the full length of the gene. The genomic coordinates used for the transcript record were based on partial human and full-length orthologous transcript alignments, including mouse BC151105.1. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2147975 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## polymorphic pseudogene :: PMID: 20820800 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGGTCCTGG CTTTCCAGTT AGTCTCCTTC ACCTACATCT GGATCATATT GAAACCAAAT 
GTTTGTGCTG CTTCTAACAT CAAGATGACA CACCAGCGGT GCTCCTCTTC AATGAAACAA 
ACCTGCAAAC AAGAAACTAG AATGAAGAAA GATGACAGTA CCAAAGCGCG GCCTCAGAAA 
TATGAGCAAC TTCTCCATAT AGAGGACAAC GATTTCGCAA TGAGACCTGG ATTTGGAGGG 
TCTCCAGTGC CAGTAGGTAT AGATGTCCAT GTTGAAAGCA TTGACAGCAT TTCAGAGACT 
AACATGGACT TTACAATGAC TTTTTATCTC AGGCATTACT GGAAAGACGA GAGGCTCTCC 
TTTCCTAGCA CAGCAAACAA AAGCATGACA TTTGATCATA GATTGACCAG AAAGATCTGG 
GTGCCTGATA TCTTTTTTGT CCACTCTAAA AGATCCTTCA TCCATGATAC AACTATGGAG 
AATATCATGC TGCGCGTACA CCCTGATGGA AACGTCCTCC TAAGTCTCAG GATAACGGTT 
TCGGCCATGT GCTTTATGGA TTTCAGCAGG TTTCCTCTTG ACACTCAAAA TTGTTCTCTT 
GAACTGGAAA GCTATGCCTA CAATGAGGAT GACCTAATGC TATACTGGAA ACACGGAAAC 
AAGTCCTTAA ATACTGAAGA ACATATGTCC CTTTCTCAGT TCTTCATTGA AGACTTCAGT 
GCATCTAGTG GATTAGCTTT CTATAGCAGC ACAGGTTGGT ACAATAGGCT TTTCATCAAC 
TTTGTGCTAA GGAGGCATGT TTTCTTCTTT GTGCTGCAAA CCTATTTCCC AGCCATATTG 
ATGGTGATGC TTTCATGGGT TTCATTTTGG ATTGACCGAA GAGCTGTTCC TGCAAGAGTT 
TCCCTGGGAA TCACCACAGT GCTGACCATG TCCACAATCA TCACTGCTGT GAGCGCCTCC 
ATGCCCCAGG TGTCCTACCT CAAGGCTGTG GATGTGTACC TGTGGGTCAG CTCCCTCTTT 
GTGTTCCTGT CAGTCATTGA GTATGCAGCT GTGAACTACC TCACCACAGT GGAAGAGCGG 
AAACAATTCA AGAAGACAGG AAAGATTTCT AGGATGTACA ATATTGATGC AGTTCAAGCT 
ATGGCCTTTG ATGGTTGTTA CCATGACAGC GAGATTGACA TGGACCAGAC TTCCCTCTCT 
CTAAACTCAG AAGACTTCAT GAGAAGAAAA TCGATATGCA GCCCCAGCAC CGATTCATCT 
CGGATAAAGA GAAGAAAATC CCTAGGAGGA CATGTTGGTA GAATCATTCT GGAAAACAAC 
CATGTCATTG ACACCTATTC TAGGATTTTA TTCCCCATTG TGTATATTTT ATTTAATTTG 
TTTTACTGGG GTGTATATGT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099050.1
CDS	118..1521
Translation	MVLAFQLVSFTYIWIILKPNVCAASNIKMTHQRCSSSMKQTCKQETRMKKDDSTKARPQKYEQLLHIEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTFYLRHYWKDERLSFPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHPDGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEHMSLSQFFIEDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVSFWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEYAAVNYLTTVEERKQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMRRKSICSPSTDSSRIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVYV

Target ORF information:

RefSeq Version	NM_001105580.2
Organism	Homo sapiens(human)
Definition	Homo sapiens gamma-aminobutyric acid type A receptor subunit rho3 (gene/pseudogene) (GABRR3), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105580.2

ORF Insert Sequence:

ATGGTCCTGG CTTTCCAGTT AGTCTCCTTC ACCTACATCT GGATCATATT GAAACCAAAT 
GTTTGTGCTG CTTCTAACAT CAAGATGACA CACCAGCGGT GCTCCTCTTC AATGAAACAA 
ACCTGCAAAC AAGAAACTAG AATGAAGAAA GATGACAGTA CCAAAGCGCG GCCTCAGAAA 
TATGAGCAAC TTCTCCATAT AGAGGACAAC GATTTCGCAA TGAGACCTGG ATTTGGAGGG 
TCTCCAGTGC CAGTAGGTAT AGATGTCCAT GTTGAAAGCA TTGACAGCAT TTCAGAGACT 
AACATGGACT TTACAATGAC TTTTTATCTC AGGCATTACT GGAAAGACGA GAGGCTCTCC 
TTTCCTAGCA CAGCAAACAA AAGCATGACA TTTGATCATA GATTGACCAG AAAGATCTGG 
GTGCCTGATA TCTTTTTTGT CCACTCTAAA AGATCCTTCA TCCATGATAC AACTATGGAG 
AATATCATGC TGCGCGTACA CCCTGATGGA AACGTCCTCC TAAGTCTCAG GATAACGGTT 
TCGGCCATGT GCTTTATGGA TTTCAGCAGG TTTCCTCTTG ACACTCAAAA TTGTTCTCTT 
GAACTGGAAA GCTATGCCTA CAATGAGGAT GACCTAATGC TATACTGGAA ACACGGAAAC 
AAGTCCTTAA ATACTGAAGA ACATATGTCC CTTTCTCAGT TCTTCATTGA AGACTTCAGT 
GCATCTAGTG GATTAGCTTT CTATAGCAGC ACAGGTTGGT ACAATAGGCT TTTCATCAAC 
TTTGTGCTAA GGAGGCATGT TTTCTTCTTT GTGCTGCAAA CCTATTTCCC AGCCATATTG 
ATGGTGATGC TTTCATGGGT TTCATTTTGG ATTGACCGAA GAGCTGTTCC TGCAAGAGTT 
TCCCTGGGAA TCACCACAGT GCTGACCATG TCCACAATCA TCACTGCTGT GAGCGCCTCC 
ATGCCCCAGG TGTCCTACCT CAAGGCTGTG GATGTGTACC TGTGGGTCAG CTCCCTCTTT 
GTGTTCCTGT CAGTCATTGA GTATGCAGCT GTGAACTACC TCACCACAGT GGAAGAGCGG 
AAACAATTCA AGAAGACAGG AAAGATTTCT AGGATGTACA ATATTGATGC AGTTCAAGCT 
ATGGCCTTTG ATGGTTGTTA CCATGACAGC GAGATTGACA TGGACCAGAC TTCCCTCTCT 
CTAAACTCAG AAGACTTCAT GAGAAGAAAA TCGATATGCA GCCCCAGCAC CGATTCATCT 
CGGATAAAGA GAAGAAAATC CCTAGGAGGA CATGTTGGTA GAATCATTCT GGAAAACAAC 
CATGTCATTG ACACCTATTC TAGGATTTTA TTCCCCATTG TGTATATTTT ATTTAATTTG 
TTTTACTGGG GTGTATATGT ATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Gamma-aminobutyric acid (GABA) receptor rho (GABRR) polymorphisms and risk for essential tremor.
Journal of neurology258(2)203-11(2011 Feb)
Garc?a-Mart?n E,Mart?nez C,Alonso-Navarro H,Benito-Le?n J,Lorenzo-Betancor O,Pastor P,Puertas I,Rubio L,L?pez-Alburquerque T,Ag?ndez JA,Jim?nez-Jim?nez FJ

Strong genetic evidence for a selective influence of GABAA receptors on a component of the bipolar disorder phenotype.
Molecular psychiatry15(2)146-53(2010 Feb)
Craddock N,Jones L,Jones IR,Kirov G,Green EK,Grozeva D,Moskvina V,Nikolov I,Hamshere ML,Vukcevic D,Caesar S,Gordon-Smith K,Fraser C,Russell E,Norton N,Breen G,St Clair D,Collier DA,Young AH,Ferrier IN,Farmer A,McGuffin P,Holmans PA,,Donnelly P,Owen MJ,O'Donovan MC

Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics150B(6)808-16(2009 Sep)
Gratac?s M,Costas J,de Cid R,Bay?s M,Gonz?lez JR,Baca-Garc?a E,de Diego Y,Fern?ndez-Aranda F,Fern?ndez-Piqueras J,Guitart M,Mart?n-Santos R,Martorell L,Mench?n JM,Roca M,S?iz-Ruiz J,Sanju?n J,Torrens M,Urretavizcaya M,Valero J,Vilella E,Estivill X,Carracedo A,

GABA receptor rho subunit expression in the developing rat brain.
Brain research. Developmental brain research154(1)15-23(2005 Jan)
Alakuijala A,Palgi M,Wegelius K,Schmidt M,Enz R,Paulin L,Saarma M,Pasternack M

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GABRR3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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