FBXO45 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	FBXO45
Entrez Gene ID	200933
Full Name	F-box protein 45
Synonyms	Fbx45
General protein information	Preferred Names F-box protein 45 Names F-box/SPRY domain-containing protein 1 F-box only protein 45 hFbxo45
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 3 Map Location: 3q29
Summary	Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011].
Disorder MIM:	609112

mRNA and Protein(s)

mRNA	Protein	Name
NM_001105573.1	NP_001099043.1	F-box/SPRY domain-containing protein 1
NM_001105573.2	NP_001099043.1	F-box/SPRY domain-containing protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	FBXO45	NP_001099043.1
Drosophila melanogaster (fruit fly)	Fsn	NP_725266.1
Caenorhabditis elegans (roundworm)	fsn-1	NP_498046.1
Mus musculus (house mouse)	Fbxo45	NP_775615.2
Rattus norvegicus (Norway rat)	Fbxo45	XP_006248538.1
Gallus gallus (chicken)	FBXO45	XP_001232841.3
Danio rerio (zebrafish)	fbxo45	NP_956889.1
Canis lupus familiaris (dog)	FBXO45	XP_851899.2
Bos taurus (cattle)	FBXO45	NP_001193687.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP012460	XP_309899.3
Xenopus tropicalis (tropical clawed frog)	fbxo45	NP_001135592.1

Gene Ontology
Bibliography

Related articles in PubMed

Low Expression of FBXO45 Is Associated with Gastric Cancer Progression and Poor Prognosis.
Kogure N, Yokobori T, Ogata K, Altan B, Mochiki E, Ohno T, Toyomasu Y, Yanai M, Kimura A, Yanoma T, Suzuki M, Bai T, Asao T, Kuwano H
Anticancer research37(1)191-196(2017 01)

Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors.
Xu M, Zhu C, Zhao X, Chen C, Zhang H, Yuan H, Deng R, Dou J, Wang Y, Huang J, Chen Q, Jiang B, Yu J
Oncotarget6(2)979-94(2015 Jan)

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.
Chen X, Sahasrabuddhe AA, Szankasi P, Chung F, Basrur V, Rangnekar VM, Pagano M, Lim MS, Elenitoba-Johnson KS
Cell death and differentiation21(10)1535-45(2014 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Relatively low FBXO45 expression in gastric cancer tissues is associated with cancer progression and constitutes an independent prognostic factor
Title: Low Expression of FBXO45 Is Associated with Gastric Cancer Progression and Poor Prognosis.

Data show that epithelial-mesenchymal transition (EMT)-transcription factors can be dynamically degraded by an atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 (SPFFbxo45).
Title: Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors.

Fbxo45 is the substrate-receptor subunit of a functional E3 ligase for Par-4 that has a critical role in cancer cell survival.
Title: Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.

Study found that the R108C mutation in FBXO45 is a rare variant with a modest effect on schizophrenia risk that may disrupt the structure and function of the FBXO45 protein
Title: Novel rare variants in F-box protein 45 (FBXO45) in schizophrenia.

FBXO45 promotes the proteasome-dependent degradation of p73.
Title: The F-box protein FBXO45 promotes the proteasome-dependent degradation of p73.

The following FBXO45 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the FBXO45 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu06265	NM_001105573.2 Latest version!	Homo sapiens F-box protein 45 (FBXO45), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu06265	NM_001105573.1	Homo sapiens F-box protein 45 (FBXO45), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

FBXO45 ( NM_001105573.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001099043.1 Homo sapiens F-box protein 45 (FBXO45), mRNA.

Price & Availability↑

CloneID	OHu06265
Clone ID Related Accession (Same CDS sequence)	NM_001105573.1 , NM_001105573.2
Accession Version	NM_001105573.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	F-box/SPRY domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DB636510.1, BE778263.1, CA445163.1, AC092933.21 and BE047625.1. On or before Sep 30, 2007 this sequence version replaced XM_931557.2, XM_946180.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.155239.1, SRR1163655.562076.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCGC CGGCCCCGGG GGCTGGGGCA GCCTCGGGCG GCGCTGGCTG TAGCGGCGGC 
GGCGCGGGCG CGGGCGCGGG CTCGGGCTCT GGGGCCGCGG GGGCCGGGGG CCGGCTGCCC 
AGCCGGGTGC TGGAGTTGGT GTTCTCTTAC CTGGAGCTGT CCGAGCTGCG GAGCTGCGCC 
CTGGTGTGCA AGCACTGGTA CCGCTGCCTG CACGGCGATG AGAACAGCGA GGTGTGGCGG 
AGCCTGTGCG CCCGCAGCCT GGCAGAAGAG GCTCTGCGCA CGGACATCCT GTGCAACCTG 
CCCAGCTACA AGGCCAAGAT ACGTGCTTTT CAACATGCCT TCAGCACTAA TGACTGCTCC 
AGGAATGTCT ACATTAAGAA GAATGGCTTT ACTTTACATC GAAACCCCAT TGCTCAGAGC 
ACTGATGGTG CAAGGACCAA GATTGGTTTC AGTGAGGGCC GCCATGCATG GGAAGTGTGG 
TGGGAGGGCC CTCTGGGCAC TGTGGCAGTG ATTGGAATTG CCACAAAACG GGCCCCCATG 
CAGTGCCAAG GTTATGTGGC ATTGCTGGGC AGTGATGACC AGAGCTGGGG CTGGAATCTG 
GTGGACAATA ATCTACTACA TAATGGAGAA GTCAATGGCA GTTTTCCACA GTGCAACAAC 
GCACCAAAAT ATCAGATAGG AGAAAGAATT CGAGTCATCT TGGACATGGA AGATAAGACT 
TTAGCTTTTG AACGTGGATA TGAGTTCCTG GGGGTTGCTT TTAGAGGACT TCCAAAGGTC 
TGCTTATACC CAGCAGTTTC TGCTGTATAT GGCAACACAG AAGTGACTTT GGTTTACCTT 
GGAAAACCTT TGGACGGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099043.1
CDS	132..992
Translation	MAAPAPGAGAASGGAGCSGGGAGAGAGSGSGAAGAGGRLPSRVLELVFSYLELSELRSCALVCKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEGPLGTVAVIGIATKRAPMQCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSFPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFRGLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG

Target ORF information:

RefSeq Version	NM_001105573.1
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 45 (FBXO45), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105573.1

ORF Insert Sequence:

ATGGCGGCGC CGGCCCCGGG GGCTGGGGCA GCCTCGGGCG GCGCTGGCTG TAGCGGCGGC 
GGCGCGGGCG CGGGCGCGGG CTCGGGCTCT GGGGCCGCGG GGGCCGGGGG CCGGCTGCCC 
AGCCGGGTGC TGGAGTTGGT GTTCTCTTAC CTGGAGCTGT CCGAGCTGCG GAGCTGCGCC 
CTGGTGTGCA AGCACTGGTA CCGCTGCCTG CACGGCGATG AGAACAGCGA GGTGTGGCGG 
AGCCTGTGCG CCCGCAGCCT GGCAGAAGAG GCTCTGCGCA CGGACATCCT GTGCAACCTG 
CCCAGCTACA AGGCCAAGAT ACGTGCTTTT CAACATGCCT TCAGCACTAA TGACTGCTCC 
AGGAATGTCT ACATTAAGAA GAATGGCTTT ACTTTACATC GAAACCCCAT TGCTCAGAGC 
ACTGATGGTG CAAGGACCAA GATTGGTTTC AGTGAGGGCC GCCATGCATG GGAAGTGTGG 
TGGGAGGGCC CTCTGGGCAC TGTGGCAGTG ATTGGAATTG CCACAAAACG GGCCCCCATG 
CAGTGCCAAG GTTATGTGGC ATTGCTGGGC AGTGATGACC AGAGCTGGGG CTGGAATCTG 
GTGGACAATA ATCTACTACA TAATGGAGAA GTCAATGGCA GTTTTCCACA GTGCAACAAC 
GCACCAAAAT ATCAGATAGG AGAAAGAATT CGAGTCATCT TGGACATGGA AGATAAGACT 
TTAGCTTTTG AACGTGGATA TGAGTTCCTG GGGGTTGCTT TTAGAGGACT TCCAAAGGTC 
TGCTTATACC CAGCAGTTTC TGCTGTATAT GGCAACACAG AAGTGACTTT GGTTTACCTT 
GGAAAACCTT TGGACGGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

FBXO45 ( NM_001105573.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001099043.1 Homo sapiens F-box protein 45 (FBXO45), mRNA.

Price & Availability↑

CloneID	OHu06265
Clone ID Related Accession (Same CDS sequence)	NM_001105573.1 , NM_001105573.2
Accession Version	NM_001105573.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 861bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-16
Organism	Homo sapiens(human)
Product	F-box/SPRY domain-containing protein 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC092933.21, DB636510.1, BE778263.1, CA445163.1 and BE047625.1. On Nov 22, 2018 this sequence version replaced NM_001105573.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.155239.1, SRR1163657.577130.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000311630.7/ ENSP00000310332.6 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGC CGGCCCCGGG GGCTGGGGCA GCCTCGGGCG GCGCTGGCTG TAGCGGCGGC 
GGCGCGGGCG CGGGCGCGGG CTCGGGCTCT GGGGCCGCGG GGGCCGGGGG CCGGCTGCCC 
AGCCGGGTGC TGGAGTTGGT GTTCTCTTAC CTGGAGCTGT CCGAGCTGCG GAGCTGCGCC 
CTGGTGTGCA AGCACTGGTA CCGCTGCCTG CACGGCGATG AGAACAGCGA GGTGTGGCGG 
AGCCTGTGCG CCCGCAGCCT GGCAGAAGAG GCTCTGCGCA CGGACATCCT GTGCAACCTG 
CCCAGCTACA AGGCCAAGAT ACGTGCTTTT CAACATGCCT TCAGCACTAA TGACTGCTCC 
AGGAATGTCT ACATTAAGAA GAATGGCTTT ACTTTACATC GAAACCCCAT TGCTCAGAGC 
ACTGATGGTG CAAGGACCAA GATTGGTTTC AGTGAGGGCC GCCATGCATG GGAAGTGTGG 
TGGGAGGGCC CTCTGGGCAC TGTGGCAGTG ATTGGAATTG CCACAAAACG GGCCCCCATG 
CAGTGCCAAG GTTATGTGGC ATTGCTGGGC AGTGATGACC AGAGCTGGGG CTGGAATCTG 
GTGGACAATA ATCTACTACA TAATGGAGAA GTCAATGGCA GTTTTCCACA GTGCAACAAC 
GCACCAAAAT ATCAGATAGG AGAAAGAATT CGAGTCATCT TGGACATGGA AGATAAGACT 
TTAGCTTTTG AACGTGGATA TGAGTTCCTG GGGGTTGCTT TTAGAGGACT TCCAAAGGTC 
TGCTTATACC CAGCAGTTTC TGCTGTATAT GGCAACACAG AAGTGACTTT GGTTTACCTT 
GGAAAACCTT TGGACGGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001099043.1
CDS	326..1186
Translation	MAAPAPGAGAASGGAGCSGGGAGAGAGSGSGAAGAGGRLPSRVLELVFSYLELSELRSCALVCKHWYRCLHGDENSEVWRSLCARSLAEEALRTDILCNLPSYKAKIRAFQHAFSTNDCSRNVYIKKNGFTLHRNPIAQSTDGARTKIGFSEGRHAWEVWWEGPLGTVAVIGIATKRAPMQCQGYVALLGSDDQSWGWNLVDNNLLHNGEVNGSFPQCNNAPKYQIGERIRVILDMEDKTLAFERGYEFLGVAFRGLPKVCLYPAVSAVYGNTEVTLVYLGKPLDG

Target ORF information:

RefSeq Version	NM_001105573.2
Organism	Homo sapiens(human)
Definition	Homo sapiens F-box protein 45 (FBXO45), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001105573.2

ORF Insert Sequence:

ATGGCGGCGC CGGCCCCGGG GGCTGGGGCA GCCTCGGGCG GCGCTGGCTG TAGCGGCGGC 
GGCGCGGGCG CGGGCGCGGG CTCGGGCTCT GGGGCCGCGG GGGCCGGGGG CCGGCTGCCC 
AGCCGGGTGC TGGAGTTGGT GTTCTCTTAC CTGGAGCTGT CCGAGCTGCG GAGCTGCGCC 
CTGGTGTGCA AGCACTGGTA CCGCTGCCTG CACGGCGATG AGAACAGCGA GGTGTGGCGG 
AGCCTGTGCG CCCGCAGCCT GGCAGAAGAG GCTCTGCGCA CGGACATCCT GTGCAACCTG 
CCCAGCTACA AGGCCAAGAT ACGTGCTTTT CAACATGCCT TCAGCACTAA TGACTGCTCC 
AGGAATGTCT ACATTAAGAA GAATGGCTTT ACTTTACATC GAAACCCCAT TGCTCAGAGC 
ACTGATGGTG CAAGGACCAA GATTGGTTTC AGTGAGGGCC GCCATGCATG GGAAGTGTGG 
TGGGAGGGCC CTCTGGGCAC TGTGGCAGTG ATTGGAATTG CCACAAAACG GGCCCCCATG 
CAGTGCCAAG GTTATGTGGC ATTGCTGGGC AGTGATGACC AGAGCTGGGG CTGGAATCTG 
GTGGACAATA ATCTACTACA TAATGGAGAA GTCAATGGCA GTTTTCCACA GTGCAACAAC 
GCACCAAAAT ATCAGATAGG AGAAAGAATT CGAGTCATCT TGGACATGGA AGATAAGACT 
TTAGCTTTTG AACGTGGATA TGAGTTCCTG GGGGTTGCTT TTAGAGGACT TCCAAAGGTC 
TGCTTATACC CAGCAGTTTC TGCTGTATAT GGCAACACAG AAGTGACTTT GGTTTACCTT 
GGAAAACCTT TGGACGGATG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Low Expression of FBXO45 Is Associated with Gastric Cancer Progression and Poor Prognosis.
Anticancer research37(1)191-196(2017 01)
Kogure N,Yokobori T,Ogata K,Altan B,Mochiki E,Ohno T,Toyomasu Y,Yanai M,Kimura A,Yanoma T,Suzuki M,Bai T,Asao T,Kuwano H

Atypical ubiquitin E3 ligase complex Skp1-Pam-Fbxo45 controls the core epithelial-to-mesenchymal transition-inducing transcription factors.
Oncotarget6(2)979-94(2015 Jan)
Xu M,Zhu C,Zhao X,Chen C,Zhang H,Yuan H,Deng R,Dou J,Wang Y,Huang J,Chen Q,Jiang B,Yu J

Fbxo45-mediated degradation of the tumor-suppressor Par-4 regulates cancer cell survival.
Cell death and differentiation21(10)1535-45(2014 Oct)
Chen X,Sahasrabuddhe AA,Szankasi P,Chung F,Basrur V,Rangnekar VM,Pagano M,Lim MS,Elenitoba-Johnson KS

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FBXO45 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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