EIF4B cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EIF4B
Entrez Gene ID	1975
Full Name	eukaryotic translation initiation factor 4B
Synonyms	EIF-4B,PRO1843
General protein information	Preferred Names eukaryotic translation initiation factor 4B Names eukaryotic translation initiation factor 4B
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 12 Map Location: 12q13.13
Disorder MIM:	603928

mRNA and Protein(s)

mRNA	Protein	Name
NM_001417.7	NP_001408.2	eukaryotic translation initiation factor 4B isoform 2
NM_001417.6	NP_001408.2	eukaryotic translation initiation factor 4B isoform 2
NM_001417.5	NP_001408.2	eukaryotic translation initiation factor 4B isoform 2
NM_001330654.1	NP_001317583.1	eukaryotic translation initiation factor 4B isoform 3
NM_001330654.2	NP_001317583.1	eukaryotic translation initiation factor 4B isoform 3
NM_001300821.2	NP_001287750.1	eukaryotic translation initiation factor 4B isoform 1
NM_001300821.3	NP_001287750.1	eukaryotic translation initiation factor 4B isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	EIF4B	XP_001142097.3
Canis lupus familiaris (dog)	EIF4B	XP_005636844.1
Danio rerio (zebrafish)	eif4bb	NP_999883.1
Homo sapiens (human)	EIF4B	NP_001408.2
Rattus norvegicus (Norway rat)	Eif4b	NP_001008325.1
Xenopus tropicalis (tropical clawed frog)	eif4b	NP_001005064.1
Danio rerio (zebrafish)	eif4ba	NP_001092707.2
Bos taurus (cattle)	EIF4B	NP_001030200.1
Mus musculus (house mouse)	Eif4b	NP_663600.2
	EIF4B	XP_001101380.2
Gallus gallus (chicken)	EIF4B	XP_003643456.2

Gene Ontology
Bibliography

Related articles in PubMed

Pim-2 Cooperates with Downstream Factor XIAP to Inhibit Apoptosis and Intensify Malignant Grade in Prostate Cancer.
Ren K, Gou X, Xiao M, He W, Kang J
Pathology oncology research : POR(2017 Nov)

Muscarinic acetylcholine receptors mediate eIF4B phosphorylation in SNU-407 colon cancer cells.
Liu Z, Cho NJ
Biochemical and biophysical research communications480(3)450-454(2016 Nov)

Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.
Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ
Proceedings of the National Academy of Sciences of the United States of America113(35)9810-5(2016 08)

eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants.
Chen K, Yang J, Li J, Wang X, Chen Y, Huang S, Chen JL
Oncotarget7(9)10073-89(2016 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Together, our data show that mAChRs modulate eIF4B phosphorylation via the ERK1/2 and PKC signaling pathways in SNU-407 colon cancer cells.
Title: Muscarinic acetylcholine receptors mediate eIF4B phosphorylation in SNU-407 colon cancer cells.

Results indicate that eIF4B integrates the signals from Pim and PI3K/Akt/mTOR pathways in Abl-expressing leukemic cells.
Title: eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants.

MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eIF4B.
Title: MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B.

S6K1 enhances c-Myc translation efficiency by modulating the phosphorylation of eukaryotic initiation factor eIF4B, which is critical to unwind its structured 5' untranslated region.
Title: The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation.

EIF4B, as a potentially key fragile point in EGFR and mTOR inhibitor synergy.
Title: Abrogating phosphorylation of eIF4B is required for EGFR and mTOR inhibitor synergy in triple-negative breast cancer.

The following EIF4B gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EIF4B cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu30924	NM_001417.6 Latest version!	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu57452	NM_001300821.2 Latest version!	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
OHu100267	NM_001330654.1 Latest version!	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu108290	NM_001300821.3 Latest version!	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu108375	NM_001417.7 Latest version!	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
OHu108383	NM_001330654.2 Latest version!	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	14-16	$307.30 $439.00
View Old Accession Versions >>
OHu30924	NM_001417.5	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EIF4B ( NM_001417.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_001408.2 Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu30924
Clone ID Related Accession (Same CDS sequence)	NM_001417.6 , NM_001417.5
Accession Version	NM_001417.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1836bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 4B isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from DC403237.1, BU431305.1, AB076839.1, BP243230.1 and AC068888.35. On Sep 1, 2016 this sequence version replaced NM_001417.5. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803612.85157.1, SRR1803617.42409.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGGCGGCCT CAGCAAAAAA GAAGAATAAG AAGGGGAAGA CTATCTCCCT AACAGACTTT 
CTGGCTGAGG ATGGGGGTAC TGGTGGAGGA AGCACCTATG TTTCCAAACC AGTCAGCTGG 
GCTGATGAAA CGGATGACCT GGAAGGAGAT GTTTCGACCA CTTGGCACAG TAACGATGAC 
GATGTGTATA GGGCGCCTCC AATTGACCGT TCCATCCTTC CCACTGCTCC ACGGGCTGCT 
CGGGAACCCA ATATCGACCG GAGCCGTCTT CCCAAATCGC CACCCTACAC TGCTTTTCTA 
GGAAACCTAC CCTATGATGT TACAGAAGAG TCAATTAAGG AATTCTTTCG AGGATTAAAT 
ATCAGTGCAG TGCGTTTACC ACGTGAACCC AGCAATCCAG AGAGGTTGAA AGGTTTTGGT 
TATGCTGAAT TTGAGGACCT GGATTCCCTG CTCAGTGCCC TGAGTCTCAA TGAAGAGTCT 
CTAGGTAACA GGAGAATTCG AGTGGACGTT GCTGATCAAG CACAGGATAA AGACAGGGAT 
GATCGTTCTT TTGGCCGTGA TAGAAATCGG GATTCTGACA AAACAGATAC AGACTGGAGG 
GCTCGTCCTG CTACAGACAG CTTTGATGAC TACCCACCTA GAAGAGGTGA TGATAGCTTT 
GGAGACAAGT ATCGAGATCG TTATGATTCA GACCGGTATC GGGATGGGTA TCGGGATGGG 
TATCGGGATG GCCCACGCCG GGATATGGAT CGATATGGTG GCCGGGATCG CTATGATGAC 
CGAGGCAGCA GAGACTATGA TAGAGGCTAT GATTCCCGGA TAGGCAGTGG CAGAAGAGCA 
TTTGGCAGTG GGTATCGCAG GGATGATGAC TACAGAGGAG GCGGGGACCG CTATGAAGAC 
CGATATGACA GACGGGATGA TCGGTCGTGG AGCTCCAGAG ATGATTACTC TCGGGATGAT 
TATAGGCGTG ATGATAGAGG TCCCCCCCAA AGACCCAAAC TGAATCTAAA GCCTCGGAGT 
ACTCCTAAGG AAGATGATTC CTCTGCTAGT ACCTCCCAGT CCACTCGAGC TGCTTCTATC 
TTTGGAGGGG CAAAGCCTGT TGACACAGCT GCTAGAGAAA GAGAAGTAGA AGAACGGCTA 
CAGAAGGAAC AAGAGAAGTT GCAGCGTCAG CTGGATGAGC CAAAACTAGA ACGACGGCCT 
CGGGAGAGAC ACCCAAGCTG GCGAAGTGAA GAAACTCAGG AACGGGAACG GTCGAGGACA 
GGAAGTGAGT CATCACAAAC TGGGACCTCC ACCACATCTA GCAGAAATGC ACGAAGGAGA 
GAGAGTGAGA AGTCTCTAGA AAATGAAACA CTCAATAAGG AGGAAGATTG CCACTCTCCA 
ACTTCTAAAC CTCCCAAACC TGATCAGCCC CTAAAGGTAA TGCCAGCCCC TCCACCAAAG 
GAGAATGCTT GGGTGAAGCG AAGTTCTAAC CCTCCTGCTC GATCTCAGAG CTCAGACACA 
GAGCAGCAGT CCCCTACAAG TGGTGGGGGA AAAGTAGCTC CAGCTCAACC ATCTGAGGAA 
GGACCAGGAA GGAAAGATGA AAATAAAGTA GATGGGATGA ATGCCCCAAA AGGCCAAACT 
GGGAACTCTA GCCGTGGTCC AGGAGACGGA GGGAACAGAG ACCACTGGAA GGAGTCAGAT 
AGGAAAGATG GCAAAAAGGA TCAAGACTCC AGATCTGCAC CTGAGCCAAA GAAACCTGAG 
GAAAATCCAG CTTCCAAGTT CAGTTCTGCA AGCAAGTATG CTGCTCTCTC TGTTGATGGT 
GAAGATGAAA ATGAGGGAGA AGATTATGCC GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001408.2
CDS	227..2062
Translation	MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSRNARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE

Target ORF information:

RefSeq Version	NM_001417.6
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001417.6

ORF Insert Sequence:

ATGGCGGCCT CAGCAAAAAA GAAGAATAAG AAGGGGAAGA CTATCTCCCT AACAGACTTT 
CTGGCTGAGG ATGGGGGTAC TGGTGGAGGA AGCACCTATG TTTCCAAACC AGTCAGCTGG 
GCTGATGAAA CGGATGACCT GGAAGGAGAT GTTTCGACCA CTTGGCACAG TAACGATGAC 
GATGTGTATA GGGCGCCTCC AATTGACCGT TCCATCCTTC CCACTGCTCC ACGGGCTGCT 
CGGGAACCCA ATATCGACCG GAGCCGTCTT CCCAAATCGC CACCCTACAC TGCTTTTCTA 
GGAAACCTAC CCTATGATGT TACAGAAGAG TCAATTAAGG AATTCTTTCG AGGATTAAAT 
ATCAGTGCAG TGCGTTTACC ACGTGAACCC AGCAATCCAG AGAGGTTGAA AGGTTTTGGT 
TATGCTGAAT TTGAGGACCT GGATTCCCTG CTCAGTGCCC TGAGTCTCAA TGAAGAGTCT 
CTAGGTAACA GGAGAATTCG AGTGGACGTT GCTGATCAAG CACAGGATAA AGACAGGGAT 
GATCGTTCTT TTGGCCGTGA TAGAAATCGG GATTCTGACA AAACAGATAC AGACTGGAGG 
GCTCGTCCTG CTACAGACAG CTTTGATGAC TACCCACCTA GAAGAGGTGA TGATAGCTTT 
GGAGACAAGT ATCGAGATCG TTATGATTCA GACCGGTATC GGGATGGGTA TCGGGATGGG 
TATCGGGATG GCCCACGCCG GGATATGGAT CGATATGGTG GCCGGGATCG CTATGATGAC 
CGAGGCAGCA GAGACTATGA TAGAGGCTAT GATTCCCGGA TAGGCAGTGG CAGAAGAGCA 
TTTGGCAGTG GGTATCGCAG GGATGATGAC TACAGAGGAG GCGGGGACCG CTATGAAGAC 
CGATATGACA GACGGGATGA TCGGTCGTGG AGCTCCAGAG ATGATTACTC TCGGGATGAT 
TATAGGCGTG ATGATAGAGG TCCCCCCCAA AGACCCAAAC TGAATCTAAA GCCTCGGAGT 
ACTCCTAAGG AAGATGATTC CTCTGCTAGT ACCTCCCAGT CCACTCGAGC TGCTTCTATC 
TTTGGAGGGG CAAAGCCTGT TGACACAGCT GCTAGAGAAA GAGAAGTAGA AGAACGGCTA 
CAGAAGGAAC AAGAGAAGTT GCAGCGTCAG CTGGATGAGC CAAAACTAGA ACGACGGCCT 
CGGGAGAGAC ACCCAAGCTG GCGAAGTGAA GAAACTCAGG AACGGGAACG GTCGAGGACA 
GGAAGTGAGT CATCACAAAC TGGGACCTCC ACCACATCTA GCAGAAATGC ACGAAGGAGA 
GAGAGTGAGA AGTCTCTAGA AAATGAAACA CTCAATAAGG AGGAAGATTG CCACTCTCCA 
ACTTCTAAAC CTCCCAAACC TGATCAGCCC CTAAAGGTAA TGCCAGCCCC TCCACCAAAG 
GAGAATGCTT GGGTGAAGCG AAGTTCTAAC CCTCCTGCTC GATCTCAGAG CTCAGACACA 
GAGCAGCAGT CCCCTACAAG TGGTGGGGGA AAAGTAGCTC CAGCTCAACC ATCTGAGGAA 
GGACCAGGAA GGAAAGATGA AAATAAAGTA GATGGGATGA ATGCCCCAAA AGGCCAAACT 
GGGAACTCTA GCCGTGGTCC AGGAGACGGA GGGAACAGAG ACCACTGGAA GGAGTCAGAT 
AGGAAAGATG GCAAAAAGGA TCAAGACTCC AGATCTGCAC CTGAGCCAAA GAAACCTGAG 
GAAAATCCAG CTTCCAAGTT CAGTTCTGCA AGCAAGTATG CTGCTCTCTC TGTTGATGGT 
GAAGATGAAA ATGAGGGAGA AGATTATGCC GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4B ( NM_001417.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001408.2 Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu30924
Clone ID Related Accession (Same CDS sequence)	NM_001417.6 , NM_001417.5
Accession Version	NM_001417.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1836bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	eukaryotic translation initiation factor 4B isoform 2
Comment

ATGGCGGCCT CAGCAAAAAA GAAGAATAAG AAGGGGAAGA CTATCTCCCT AACAGACTTT 
CTGGCTGAGG ATGGGGGTAC TGGTGGAGGA AGCACCTATG TTTCCAAACC AGTCAGCTGG 
GCTGATGAAA CGGATGACCT GGAAGGAGAT GTTTCGACCA CTTGGCACAG TAACGATGAC 
GATGTGTATA GGGCGCCTCC AATTGACCGT TCCATCCTTC CCACTGCTCC ACGGGCTGCT 
CGGGAACCCA ATATCGACCG GAGCCGTCTT CCCAAATCGC CACCCTACAC TGCTTTTCTA 
GGAAACCTAC CCTATGATGT TACAGAAGAG TCAATTAAGG AATTCTTTCG AGGATTAAAT 
ATCAGTGCAG TGCGTTTACC ACGTGAACCC AGCAATCCAG AGAGGTTGAA AGGTTTTGGT 
TATGCTGAAT TTGAGGACCT GGATTCCCTG CTCAGTGCCC TGAGTCTCAA TGAAGAGTCT 
CTAGGTAACA GGAGAATTCG AGTGGACGTT GCTGATCAAG CACAGGATAA AGACAGGGAT 
GATCGTTCTT TTGGCCGTGA TAGAAATCGG GATTCTGACA AAACAGATAC AGACTGGAGG 
GCTCGTCCTG CTACAGACAG CTTTGATGAC TACCCACCTA GAAGAGGTGA TGATAGCTTT 
GGAGACAAGT ATCGAGATCG TTATGATTCA GACCGGTATC GGGATGGGTA TCGGGATGGG 
TATCGGGATG GCCCACGCCG GGATATGGAT CGATATGGTG GCCGGGATCG CTATGATGAC 
CGAGGCAGCA GAGACTATGA TAGAGGCTAT GATTCCCGGA TAGGCAGTGG CAGAAGAGCA 
TTTGGCAGTG GGTATCGCAG GGATGATGAC TACAGAGGAG GCGGGGACCG CTATGAAGAC 
CGATATGACA GACGGGATGA TCGGTCGTGG AGCTCCAGAG ATGATTACTC TCGGGATGAT 
TATAGGCGTG ATGATAGAGG TCCCCCCCAA AGACCCAAAC TGAATCTAAA GCCTCGGAGT 
ACTCCTAAGG AAGATGATTC CTCTGCTAGT ACCTCCCAGT CCACTCGAGC TGCTTCTATC 
TTTGGAGGGG CAAAGCCTGT TGACACAGCT GCTAGAGAAA GAGAAGTAGA AGAACGGCTA 
CAGAAGGAAC AAGAGAAGTT GCAGCGTCAG CTGGATGAGC CAAAACTAGA ACGACGGCCT 
CGGGAGAGAC ACCCAAGCTG GCGAAGTGAA GAAACTCAGG AACGGGAACG GTCGAGGACA 
GGAAGTGAGT CATCACAAAC TGGGACCTCC ACCACATCTA GCAGAAATGC ACGAAGGAGA 
GAGAGTGAGA AGTCTCTAGA AAATGAAACA CTCAATAAGG AGGAAGATTG CCACTCTCCA 
ACTTCTAAAC CTCCCAAACC TGATCAGCCC CTAAAGGTAA TGCCAGCCCC TCCACCAAAG 
GAGAATGCTT GGGTGAAGCG AAGTTCTAAC CCTCCTGCTC GATCTCAGAG CTCAGACACA 
GAGCAGCAGT CCCCTACAAG TGGTGGGGGA AAAGTAGCTC CAGCTCAACC ATCTGAGGAA 
GGACCAGGAA GGAAAGATGA AAATAAAGTA GATGGGATGA ATGCCCCAAA AGGCCAAACT 
GGGAACTCTA GCCGTGGTCC AGGAGACGGA GGGAACAGAG ACCACTGGAA GGAGTCAGAT 
AGGAAAGATG GCAAAAAGGA TCAAGACTCC AGATCTGCAC CTGAGCCAAA GAAACCTGAG 
GAAAATCCAG CTTCCAAGTT CAGTTCTGCA AGCAAGTATG CTGCTCTCTC TGTTGATGGT 
GAAGATGAAA ATGAGGGAGA AGATTATGCC GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq

NP_001408.2

Translation

MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSRNARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE

Target ORF information:

RefSeq Version	NM_001417.5
Organism	Homo sapiens(Human)
Definition	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001417.5

ORF Insert Sequence:

ATGGCGGCCT CAGCAAAAAA GAAGAATAAG AAGGGGAAGA CTATCTCCCT AACAGACTTT 
CTGGCTGAGG ATGGGGGTAC TGGTGGAGGA AGCACCTATG TTTCCAAACC AGTCAGCTGG 
GCTGATGAAA CGGATGACCT GGAAGGAGAT GTTTCGACCA CTTGGCACAG TAACGATGAC 
GATGTGTATA GGGCGCCTCC AATTGACCGT TCCATCCTTC CCACTGCTCC ACGGGCTGCT 
CGGGAACCCA ATATCGACCG GAGCCGTCTT CCCAAATCGC CACCCTACAC TGCTTTTCTA 
GGAAACCTAC CCTATGATGT TACAGAAGAG TCAATTAAGG AATTCTTTCG AGGATTAAAT 
ATCAGTGCAG TGCGTTTACC ACGTGAACCC AGCAATCCAG AGAGGTTGAA AGGTTTTGGT 
TATGCTGAAT TTGAGGACCT GGATTCCCTG CTCAGTGCCC TGAGTCTCAA TGAAGAGTCT 
CTAGGTAACA GGAGAATTCG AGTGGACGTT GCTGATCAAG CACAGGATAA AGACAGGGAT 
GATCGTTCTT TTGGCCGTGA TAGAAATCGG GATTCTGACA AAACAGATAC AGACTGGAGG 
GCTCGTCCTG CTACAGACAG CTTTGATGAC TACCCACCTA GAAGAGGTGA TGATAGCTTT 
GGAGACAAGT ATCGAGATCG TTATGATTCA GACCGGTATC GGGATGGGTA TCGGGATGGG 
TATCGGGATG GCCCACGCCG GGATATGGAT CGATATGGTG GCCGGGATCG CTATGATGAC 
CGAGGCAGCA GAGACTATGA TAGAGGCTAT GATTCCCGGA TAGGCAGTGG CAGAAGAGCA 
TTTGGCAGTG GGTATCGCAG GGATGATGAC TACAGAGGAG GCGGGGACCG CTATGAAGAC 
CGATATGACA GACGGGATGA TCGGTCGTGG AGCTCCAGAG ATGATTACTC TCGGGATGAT 
TATAGGCGTG ATGATAGAGG TCCCCCCCAA AGACCCAAAC TGAATCTAAA GCCTCGGAGT 
ACTCCTAAGG AAGATGATTC CTCTGCTAGT ACCTCCCAGT CCACTCGAGC TGCTTCTATC 
TTTGGAGGGG CAAAGCCTGT TGACACAGCT GCTAGAGAAA GAGAAGTAGA AGAACGGCTA 
CAGAAGGAAC AAGAGAAGTT GCAGCGTCAG CTGGATGAGC CAAAACTAGA ACGACGGCCT 
CGGGAGAGAC ACCCAAGCTG GCGAAGTGAA GAAACTCAGG AACGGGAACG GTCGAGGACA 
GGAAGTGAGT CATCACAAAC TGGGACCTCC ACCACATCTA GCAGAAATGC ACGAAGGAGA 
GAGAGTGAGA AGTCTCTAGA AAATGAAACA CTCAATAAGG AGGAAGATTG CCACTCTCCA 
ACTTCTAAAC CTCCCAAACC TGATCAGCCC CTAAAGGTAA TGCCAGCCCC TCCACCAAAG 
GAGAATGCTT GGGTGAAGCG AAGTTCTAAC CCTCCTGCTC GATCTCAGAG CTCAGACACA 
GAGCAGCAGT CCCCTACAAG TGGTGGGGGA AAAGTAGCTC CAGCTCAACC ATCTGAGGAA 
GGACCAGGAA GGAAAGATGA AAATAAAGTA GATGGGATGA ATGCCCCAAA AGGCCAAACT 
GGGAACTCTA GCCGTGGTCC AGGAGACGGA GGGAACAGAG ACCACTGGAA GGAGTCAGAT 
AGGAAAGATG GCAAAAAGGA TCAAGACTCC AGATCTGCAC CTGAGCCAAA GAAACCTGAG 
GAAAATCCAG CTTCCAAGTT CAGTTCTGCA AGCAAGTATG CTGCTCTCTC TGTTGATGGT 
GAAGATGAAA ATGAGGGAGA AGATTATGCC GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4B ( NM_001300821.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001287750.1 Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu57452
Clone ID Related Accession (Same CDS sequence)	NM_001300821.2
Accession Version	NM_001300821.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1851bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 4B isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC403237.1, AC068888.35, AK299329.1 and BC001097.1. On Sep 1, 2016 this sequence version replaced NM_001300821.1. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803613.242454.1, SRR1803611.218631.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCT CAGCAAAAAA GAAGAATAAG AAGGGGAAGA CTATCTCCCT AACAGACTTT 
CTGGCTGAGG ATGGGGGTAC TGGTGGAGGA AGCACCTATG TTTCCAAACC AGTCAGCTGG 
GCTGATGAAA CGGATGACCT GGAAGGAGAT GTTTCGACCA CTTGGCACAG TAACGATGAC 
GATGTGTATA GGGCGCCTCC AATTGACCGT TCCATCCTTC CCACTGCTCC ACGGGCTGCT 
CGGGAACCCA ATATCGACCG GAGCCGTCTT CCCAAATCGC CACCCTACAC TGCTTTTCTA 
GGAAACCTAC CCTATGATGT TACAGAAGAG TCAATTAAGG AATTCTTTCG AGGATTAAAT 
ATCAGTGCAG TGCGTTTACC ACGTGAACCC AGCAATCCAG AGAGGTTGAA AGGTTTTGGT 
TATGCTGAAT TTGAGGACCT GGATTCCCTG CTCAGTGCCC TGAGTCTCAA TGAAGAGTCT 
CTAGGTAACA GGAGAATTCG AGTGGACGTT GCTGATCAAG CACAGGATAA AGACAGGGAT 
GATCGTTCTT TTGGCCGTGA TAGAAATCGG GATTCTGACA AAACAGATAC AGACTGGAGG 
GCTCGTCCTG CTACAGACAG CTTTGATGAC TACCCACCTA GAAGAGGTGA TGATAGCTTT 
GGAGACAAGT ATCGAGATCG TTATGATTCA GACCGGTATC GGGATGGGTA TCGGGATGGG 
TATCGGGATG GCCCACGCCG GGATATGGAT CGATATGGTG GCCGGGATCG CTATGATGAC 
CGAGGCAGCA GAGACTATGA TAGAGGCTAT GATTCCCGGA TAGGCAGTGG CAGAAGAGCA 
TTTGGCAGTG GGTATCGCAG GGATGATGAC TACAGAGGAG GCGGGGACCG CTATGAAGAC 
CGATATGACA GACGGGATGA TCGGTCGTGG AGCTCCAGAG ATGATTACTC TCGGGATGAT 
TATAGGCGTG ATGATAGAGG TCCCCCCCAA AGACCCAAAC TGAATCTAAA GCCTCGGAGT 
ACTCCTAAGG AAGATGATTC CTCTGCTAGT ACCTCCCAGT CCACTCGAGC TGCTTCTATC 
TTTGGAGGGG CAAAGCCTGT TGACACAGCT GCTAGAGAAA GAGAAGTAGA AGAACGGCTA 
CAGAAGGAAC AAGAGAAGTT GCAGCGTCAG CTGGATGAGC CAAAACTAGA ACGACGGCCT 
CGGGAGAGAC ACCCAAGCTG GCGAAGTGAA GAAACTCAGG AACGGGAACG GTCGAGGACA 
GGAAGTGAGT CATCACAAAC TGGGACCTCC ACCACATCTA GCAGAAGTAA GTCAGACCAG 
GATGCACGAA GGAGAGAGAG TGAGAAGTCT CTAGAAAATG AAACACTCAA TAAGGAGGAA 
GATTGCCACT CTCCAACTTC TAAACCTCCC AAACCTGATC AGCCCCTAAA GGTAATGCCA 
GCCCCTCCAC CAAAGGAGAA TGCTTGGGTG AAGCGAAGTT CTAACCCTCC TGCTCGATCT 
CAGAGCTCAG ACACAGAGCA GCAGTCCCCT ACAAGTGGTG GGGGAAAAGT AGCTCCAGCT 
CAACCATCTG AGGAAGGACC AGGAAGGAAA GATGAAAATA AAGTAGATGG GATGAATGCC 
CCAAAAGGCC AAACTGGGAA CTCTAGCCGT GGTCCAGGAG ACGGAGGGAA CAGAGACCAC 
TGGAAGGAGT CAGATAGGAA AGATGGCAAA AAGGATCAAG ACTCCAGATC TGCACCTGAG 
CCAAAGAAAC CTGAGGAAAA TCCAGCTTCC AAGTTCAGTT CTGCAAGCAA GTATGCTGCT 
CTCTCTGTTG ATGGTGAAGA TGAAAATGAG GGAGAAGATT ATGCCGAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287750.1
CDS	227..2077
Translation	MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSRSKSDQDARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE

Target ORF information:

RefSeq Version	NM_001300821.2
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300821.2

ORF Insert Sequence:

ATGGCGGCCT CAGCAAAAAA GAAGAATAAG AAGGGGAAGA CTATCTCCCT AACAGACTTT 
CTGGCTGAGG ATGGGGGTAC TGGTGGAGGA AGCACCTATG TTTCCAAACC AGTCAGCTGG 
GCTGATGAAA CGGATGACCT GGAAGGAGAT GTTTCGACCA CTTGGCACAG TAACGATGAC 
GATGTGTATA GGGCGCCTCC AATTGACCGT TCCATCCTTC CCACTGCTCC ACGGGCTGCT 
CGGGAACCCA ATATCGACCG GAGCCGTCTT CCCAAATCGC CACCCTACAC TGCTTTTCTA 
GGAAACCTAC CCTATGATGT TACAGAAGAG TCAATTAAGG AATTCTTTCG AGGATTAAAT 
ATCAGTGCAG TGCGTTTACC ACGTGAACCC AGCAATCCAG AGAGGTTGAA AGGTTTTGGT 
TATGCTGAAT TTGAGGACCT GGATTCCCTG CTCAGTGCCC TGAGTCTCAA TGAAGAGTCT 
CTAGGTAACA GGAGAATTCG AGTGGACGTT GCTGATCAAG CACAGGATAA AGACAGGGAT 
GATCGTTCTT TTGGCCGTGA TAGAAATCGG GATTCTGACA AAACAGATAC AGACTGGAGG 
GCTCGTCCTG CTACAGACAG CTTTGATGAC TACCCACCTA GAAGAGGTGA TGATAGCTTT 
GGAGACAAGT ATCGAGATCG TTATGATTCA GACCGGTATC GGGATGGGTA TCGGGATGGG 
TATCGGGATG GCCCACGCCG GGATATGGAT CGATATGGTG GCCGGGATCG CTATGATGAC 
CGAGGCAGCA GAGACTATGA TAGAGGCTAT GATTCCCGGA TAGGCAGTGG CAGAAGAGCA 
TTTGGCAGTG GGTATCGCAG GGATGATGAC TACAGAGGAG GCGGGGACCG CTATGAAGAC 
CGATATGACA GACGGGATGA TCGGTCGTGG AGCTCCAGAG ATGATTACTC TCGGGATGAT 
TATAGGCGTG ATGATAGAGG TCCCCCCCAA AGACCCAAAC TGAATCTAAA GCCTCGGAGT 
ACTCCTAAGG AAGATGATTC CTCTGCTAGT ACCTCCCAGT CCACTCGAGC TGCTTCTATC 
TTTGGAGGGG CAAAGCCTGT TGACACAGCT GCTAGAGAAA GAGAAGTAGA AGAACGGCTA 
CAGAAGGAAC AAGAGAAGTT GCAGCGTCAG CTGGATGAGC CAAAACTAGA ACGACGGCCT 
CGGGAGAGAC ACCCAAGCTG GCGAAGTGAA GAAACTCAGG AACGGGAACG GTCGAGGACA 
GGAAGTGAGT CATCACAAAC TGGGACCTCC ACCACATCTA GCAGAAGTAA GTCAGACCAG 
GATGCACGAA GGAGAGAGAG TGAGAAGTCT CTAGAAAATG AAACACTCAA TAAGGAGGAA 
GATTGCCACT CTCCAACTTC TAAACCTCCC AAACCTGATC AGCCCCTAAA GGTAATGCCA 
GCCCCTCCAC CAAAGGAGAA TGCTTGGGTG AAGCGAAGTT CTAACCCTCC TGCTCGATCT 
CAGAGCTCAG ACACAGAGCA GCAGTCCCCT ACAAGTGGTG GGGGAAAAGT AGCTCCAGCT 
CAACCATCTG AGGAAGGACC AGGAAGGAAA GATGAAAATA AAGTAGATGG GATGAATGCC 
CCAAAAGGCC AAACTGGGAA CTCTAGCCGT GGTCCAGGAG ACGGAGGGAA CAGAGACCAC 
TGGAAGGAGT CAGATAGGAA AGATGGCAAA AAGGATCAAG ACTCCAGATC TGCACCTGAG 
CCAAAGAAAC CTGAGGAAAA TCCAGCTTCC AAGTTCAGTT CTGCAAGCAA GTATGCTGCT 
CTCTCTGTTG ATGGTGAAGA TGAAAATGAG GGAGAAGATT ATGCCGAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4B ( NM_001330654.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001317583.1 Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 3, mRNA.

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CloneID	OHu100267
Clone ID Related Accession (Same CDS sequence)	NM_001330654.1
Accession Version	NM_001330654.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1719bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-03-03
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 4B isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from DC403237.1, AC068888.35, AK299526.1 and BP243230.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK299526.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCT CAGCAAAAAA GAAGAATAAG AAGGGGAAGA CTATCTCCCT AACAGACTTT 
CTGGCTGAGG ATGGGGGTAC TGGTGGAGGA AGCACCTATG TTTCCAAACC AGTCAGCTGG 
GCTGATGAAA CGGATGACCT GGAAGGAGAT GTTTCGACCA CTTGGCACAG TAACGATGAC 
GATGTGTATA GGGCGCCTCC AATTGACCGT TCCATCCTTC CCACTGCTCC ACGGGCTGCT 
CGGGAACCCA ATATCGACCG GAGCCGTCTT CCCAAATCGC CACCCTACAC TGCTTTTCTA 
GGAAACCTAC CCTATGATGT TACAGAAGAG TCAATTAAGG AATTCTTTCG AGGATTAAAT 
TCTCTAGGTA ACAGGAGAAT TCGAGTGGAC GTTGCTGATC AAGCACAGGA TAAAGACAGG 
GATGATCGTT CTTTTGGCCG TGATAGAAAT CGGGATTCTG ACAAAACAGA TACAGACTGG 
AGGGCTCGTC CTGCTACAGA CAGCTTTGAT GACTACCCAC CTAGAAGAGG TGATGATAGC 
TTTGGAGACA AGTATCGAGA TCGTTATGAT TCAGACCGGT ATCGGGATGG GTATCGGGAT 
GGGTATCGGG ATGGCCCACG CCGGGATATG GATCGATATG GTGGCCGGGA TCGCTATGAT 
GACCGAGGCA GCAGAGACTA TGATAGAGGC TATGATTCCC GGATAGGCAG TGGCAGAAGA 
GCATTTGGCA GTGGGTATCG CAGGGATGAT GACTACAGAG GAGGCGGGGA CCGCTATGAA 
GACCGATATG ACAGACGGGA TGATCGGTCG TGGAGCTCCA GAGATGATTA CTCTCGGGAT 
GATTATAGGC GTGATGATAG AGGTCCCCCC CAAAGACCCA AACTGAATCT AAAGCCTCGG 
AGTACTCCTA AGGAAGATGA TTCCTCTGCT AGTACCTCCC AGTCCACTCG AGCTGCTTCT 
ATCTTTGGAG GGGCAAAGCC TGTTGACACA GCTGCTAGAG AAAGAGAAGT AGAAGAACGG 
CTACAGAAGG AACAAGAGAA GTTGCAGCGT CAGCTGGATG AGCCAAAACT AGAACGACGG 
CCTCGGGAGA GACACCCAAG CTGGCGAAGT GAAGAAACTC AGGAACGGGA ACGGTCGAGG 
ACAGGAAGTG AGTCATCACA AACTGGGACC TCCACCACAT CTAGCAGAAA TGCACGAAGG 
AGAGAGAGTG AGAAGTCTCT AGAAAATGAA ACACTCAATA AGGAGGAAGA TTGCCACTCT 
CCAACTTCTA AACCTCCCAA ACCTGATCAG CCCCTAAAGG TAATGCCAGC CCCTCCACCA 
AAGGAGAATG CTTGGGTGAA GCGAAGTTCT AACCCTCCTG CTCGATCTCA GAGCTCAGAC 
ACAGAGCAGC AGTCCCCTAC AAGTGGTGGG GGAAAAGTAG CTCCAGCTCA ACCATCTGAG 
GAAGGACCAG GAAGGAAAGA TGAAAATAAA GTAGATGGGA TGAATGCCCC AAAAGGCCAA 
ACTGGGAACT CTAGCCGTGG TCCAGGAGAC GGAGGGAACA GAGACCACTG GAAGGAGTCA 
GATAGGAAAG ATGGCAAAAA GGATCAAGAC TCCAGATCTG CACCTGAGCC AAAGAAACCT 
GAGGAAAATC CAGCTTCCAA GTTCAGTTCT GCAAGCAAGT ATGCTGCTCT CTCTGTTGAT 
GGTGAAGATG AAAATGAGGG AGAAGATTAT GCCGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001317583.1
CDS	227..1945
Translation	MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNSLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSRNARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE

Target ORF information:

RefSeq Version	NM_001330654.1
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001330654.1

ORF Insert Sequence:

ATGGCGGCCT CAGCAAAAAA GAAGAATAAG AAGGGGAAGA CTATCTCCCT AACAGACTTT 
CTGGCTGAGG ATGGGGGTAC TGGTGGAGGA AGCACCTATG TTTCCAAACC AGTCAGCTGG 
GCTGATGAAA CGGATGACCT GGAAGGAGAT GTTTCGACCA CTTGGCACAG TAACGATGAC 
GATGTGTATA GGGCGCCTCC AATTGACCGT TCCATCCTTC CCACTGCTCC ACGGGCTGCT 
CGGGAACCCA ATATCGACCG GAGCCGTCTT CCCAAATCGC CACCCTACAC TGCTTTTCTA 
GGAAACCTAC CCTATGATGT TACAGAAGAG TCAATTAAGG AATTCTTTCG AGGATTAAAT 
TCTCTAGGTA ACAGGAGAAT TCGAGTGGAC GTTGCTGATC AAGCACAGGA TAAAGACAGG 
GATGATCGTT CTTTTGGCCG TGATAGAAAT CGGGATTCTG ACAAAACAGA TACAGACTGG 
AGGGCTCGTC CTGCTACAGA CAGCTTTGAT GACTACCCAC CTAGAAGAGG TGATGATAGC 
TTTGGAGACA AGTATCGAGA TCGTTATGAT TCAGACCGGT ATCGGGATGG GTATCGGGAT 
GGGTATCGGG ATGGCCCACG CCGGGATATG GATCGATATG GTGGCCGGGA TCGCTATGAT 
GACCGAGGCA GCAGAGACTA TGATAGAGGC TATGATTCCC GGATAGGCAG TGGCAGAAGA 
GCATTTGGCA GTGGGTATCG CAGGGATGAT GACTACAGAG GAGGCGGGGA CCGCTATGAA 
GACCGATATG ACAGACGGGA TGATCGGTCG TGGAGCTCCA GAGATGATTA CTCTCGGGAT 
GATTATAGGC GTGATGATAG AGGTCCCCCC CAAAGACCCA AACTGAATCT AAAGCCTCGG 
AGTACTCCTA AGGAAGATGA TTCCTCTGCT AGTACCTCCC AGTCCACTCG AGCTGCTTCT 
ATCTTTGGAG GGGCAAAGCC TGTTGACACA GCTGCTAGAG AAAGAGAAGT AGAAGAACGG 
CTACAGAAGG AACAAGAGAA GTTGCAGCGT CAGCTGGATG AGCCAAAACT AGAACGACGG 
CCTCGGGAGA GACACCCAAG CTGGCGAAGT GAAGAAACTC AGGAACGGGA ACGGTCGAGG 
ACAGGAAGTG AGTCATCACA AACTGGGACC TCCACCACAT CTAGCAGAAA TGCACGAAGG 
AGAGAGAGTG AGAAGTCTCT AGAAAATGAA ACACTCAATA AGGAGGAAGA TTGCCACTCT 
CCAACTTCTA AACCTCCCAA ACCTGATCAG CCCCTAAAGG TAATGCCAGC CCCTCCACCA 
AAGGAGAATG CTTGGGTGAA GCGAAGTTCT AACCCTCCTG CTCGATCTCA GAGCTCAGAC 
ACAGAGCAGC AGTCCCCTAC AAGTGGTGGG GGAAAAGTAG CTCCAGCTCA ACCATCTGAG 
GAAGGACCAG GAAGGAAAGA TGAAAATAAA GTAGATGGGA TGAATGCCCC AAAAGGCCAA 
ACTGGGAACT CTAGCCGTGG TCCAGGAGAC GGAGGGAACA GAGACCACTG GAAGGAGTCA 
GATAGGAAAG ATGGCAAAAA GGATCAAGAC TCCAGATCTG CACCTGAGCC AAAGAAACCT 
GAGGAAAATC CAGCTTCCAA GTTCAGTTCT GCAAGCAAGT ATGCTGCTCT CTCTGTTGAT 
GGTGAAGATG AAAATGAGGG AGAAGATTAT GCCGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4B ( NM_001300821.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001287750.1 Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 1, mRNA.

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CloneID	OHu108290
Clone ID Related Accession (Same CDS sequence)	NM_001300821.3
Accession Version	NM_001300821.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1851bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 4B isoform 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC068888.35. On Jun 2, 2019 this sequence version replaced NM_001300821.2. Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK299329.1, SRR1803613.151194.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCT CAGCAAAAAA GAAGAATAAG AAGGGGAAGA CTATCTCCCT AACAGACTTT 
CTGGCTGAGG ATGGGGGTAC TGGTGGAGGA AGCACCTATG TTTCCAAACC AGTCAGCTGG 
GCTGATGAAA CGGATGACCT GGAAGGAGAT GTTTCGACCA CTTGGCACAG TAACGATGAC 
GATGTGTATA GGGCGCCTCC AATTGACCGT TCCATCCTTC CCACTGCTCC ACGGGCTGCT 
CGGGAACCCA ATATCGACCG GAGCCGTCTT CCCAAATCGC CACCCTACAC TGCTTTTCTA 
GGAAACCTAC CCTATGATGT TACAGAAGAG TCAATTAAGG AATTCTTTCG AGGATTAAAT 
ATCAGTGCAG TGCGTTTACC ACGTGAACCC AGCAATCCAG AGAGGTTGAA AGGTTTTGGT 
TATGCTGAAT TTGAGGACCT GGATTCCCTG CTCAGTGCCC TGAGTCTCAA TGAAGAGTCT 
CTAGGTAACA GGAGAATTCG AGTGGACGTT GCTGATCAAG CACAGGATAA AGACAGGGAT 
GATCGTTCTT TTGGCCGTGA TAGAAATCGG GATTCTGACA AAACAGATAC AGACTGGAGG 
GCTCGTCCTG CTACAGACAG CTTTGATGAC TACCCACCTA GAAGAGGTGA TGATAGCTTT 
GGAGACAAGT ATCGAGATCG TTATGATTCA GACCGGTATC GGGATGGGTA TCGGGATGGG 
TATCGGGATG GCCCACGCCG GGATATGGAT CGATATGGTG GCCGGGATCG CTATGATGAC 
CGAGGCAGCA GAGACTATGA TAGAGGCTAT GATTCCCGGA TAGGCAGTGG CAGAAGAGCA 
TTTGGCAGTG GGTATCGCAG GGATGATGAC TACAGAGGAG GCGGGGACCG CTATGAAGAC 
CGATATGACA GACGGGATGA TCGGTCGTGG AGCTCCAGAG ATGATTACTC TCGGGATGAT 
TATAGGCGTG ATGATAGAGG TCCCCCCCAA AGACCCAAAC TGAATCTAAA GCCTCGGAGT 
ACTCCTAAGG AAGATGATTC CTCTGCTAGT ACCTCCCAGT CCACTCGAGC TGCTTCTATC 
TTTGGAGGGG CAAAGCCTGT TGACACAGCT GCTAGAGAAA GAGAAGTAGA AGAACGGCTA 
CAGAAGGAAC AAGAGAAGTT GCAGCGTCAG CTGGATGAGC CAAAACTAGA ACGACGGCCT 
CGGGAGAGAC ACCCAAGCTG GCGAAGTGAA GAAACTCAGG AACGGGAACG GTCGAGGACA 
GGAAGTGAGT CATCACAAAC TGGGACCTCC ACCACATCTA GCAGAAGTAA GTCAGACCAG 
GATGCACGAA GGAGAGAGAG TGAGAAGTCT CTAGAAAATG AAACACTCAA TAAGGAGGAA 
GATTGCCACT CTCCAACTTC TAAACCTCCC AAACCTGATC AGCCCCTAAA GGTAATGCCA 
GCCCCTCCAC CAAAGGAGAA TGCTTGGGTG AAGCGAAGTT CTAACCCTCC TGCTCGATCT 
CAGAGCTCAG ACACAGAGCA GCAGTCCCCT ACAAGTGGTG GGGGAAAAGT AGCTCCAGCT 
CAACCATCTG AGGAAGGACC AGGAAGGAAA GATGAAAATA AAGTAGATGG GATGAATGCC 
CCAAAAGGCC AAACTGGGAA CTCTAGCCGT GGTCCAGGCG ACGGAGGGAA CAGAGACCAC 
TGGAAGGAGT CAGATAGGAA AGATGGCAAA AAGGATCAAG ACTCCAGATC TGCACCTGAG 
CCAAAGAAAC CTGAGGAAAA TCCAGCTTCC AAGTTCAGTT CTGCAAGCAA GTATGCTGCT 
CTCTCTGTTG ATGGTGAAGA TGAAAATGAG GGAGAAGATT ATGCCGAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001287750.1
CDS	29..1879
Translation	MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSRSKSDQDARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE

Target ORF information:

RefSeq Version	NM_001300821.3
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001300821.3

ORF Insert Sequence:

ATGGCGGCCT CAGCAAAAAA GAAGAATAAG AAGGGGAAGA CTATCTCCCT AACAGACTTT 
CTGGCTGAGG ATGGGGGTAC TGGTGGAGGA AGCACCTATG TTTCCAAACC AGTCAGCTGG 
GCTGATGAAA CGGATGACCT GGAAGGAGAT GTTTCGACCA CTTGGCACAG TAACGATGAC 
GATGTGTATA GGGCGCCTCC AATTGACCGT TCCATCCTTC CCACTGCTCC ACGGGCTGCT 
CGGGAACCCA ATATCGACCG GAGCCGTCTT CCCAAATCGC CACCCTACAC TGCTTTTCTA 
GGAAACCTAC CCTATGATGT TACAGAAGAG TCAATTAAGG AATTCTTTCG AGGATTAAAT 
ATCAGTGCAG TGCGTTTACC ACGTGAACCC AGCAATCCAG AGAGGTTGAA AGGTTTTGGT 
TATGCTGAAT TTGAGGACCT GGATTCCCTG CTCAGTGCCC TGAGTCTCAA TGAAGAGTCT 
CTAGGTAACA GGAGAATTCG AGTGGACGTT GCTGATCAAG CACAGGATAA AGACAGGGAT 
GATCGTTCTT TTGGCCGTGA TAGAAATCGG GATTCTGACA AAACAGATAC AGACTGGAGG 
GCTCGTCCTG CTACAGACAG CTTTGATGAC TACCCACCTA GAAGAGGTGA TGATAGCTTT 
GGAGACAAGT ATCGAGATCG TTATGATTCA GACCGGTATC GGGATGGGTA TCGGGATGGG 
TATCGGGATG GCCCACGCCG GGATATGGAT CGATATGGTG GCCGGGATCG CTATGATGAC 
CGAGGCAGCA GAGACTATGA TAGAGGCTAT GATTCCCGGA TAGGCAGTGG CAGAAGAGCA 
TTTGGCAGTG GGTATCGCAG GGATGATGAC TACAGAGGAG GCGGGGACCG CTATGAAGAC 
CGATATGACA GACGGGATGA TCGGTCGTGG AGCTCCAGAG ATGATTACTC TCGGGATGAT 
TATAGGCGTG ATGATAGAGG TCCCCCCCAA AGACCCAAAC TGAATCTAAA GCCTCGGAGT 
ACTCCTAAGG AAGATGATTC CTCTGCTAGT ACCTCCCAGT CCACTCGAGC TGCTTCTATC 
TTTGGAGGGG CAAAGCCTGT TGACACAGCT GCTAGAGAAA GAGAAGTAGA AGAACGGCTA 
CAGAAGGAAC AAGAGAAGTT GCAGCGTCAG CTGGATGAGC CAAAACTAGA ACGACGGCCT 
CGGGAGAGAC ACCCAAGCTG GCGAAGTGAA GAAACTCAGG AACGGGAACG GTCGAGGACA 
GGAAGTGAGT CATCACAAAC TGGGACCTCC ACCACATCTA GCAGAAGTAA GTCAGACCAG 
GATGCACGAA GGAGAGAGAG TGAGAAGTCT CTAGAAAATG AAACACTCAA TAAGGAGGAA 
GATTGCCACT CTCCAACTTC TAAACCTCCC AAACCTGATC AGCCCCTAAA GGTAATGCCA 
GCCCCTCCAC CAAAGGAGAA TGCTTGGGTG AAGCGAAGTT CTAACCCTCC TGCTCGATCT 
CAGAGCTCAG ACACAGAGCA GCAGTCCCCT ACAAGTGGTG GGGGAAAAGT AGCTCCAGCT 
CAACCATCTG AGGAAGGACC AGGAAGGAAA GATGAAAATA AAGTAGATGG GATGAATGCC 
CCAAAAGGCC AAACTGGGAA CTCTAGCCGT GGTCCAGGCG ACGGAGGGAA CAGAGACCAC 
TGGAAGGAGT CAGATAGGAA AGATGGCAAA AAGGATCAAG ACTCCAGATC TGCACCTGAG 
CCAAAGAAAC CTGAGGAAAA TCCAGCTTCC AAGTTCAGTT CTGCAAGCAA GTATGCTGCT 
CTCTCTGTTG ATGGTGAAGA TGAAAATGAG GGAGAAGATT ATGCCGAATA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4B ( NM_001417.7 ) cDNA ORF clone, Homo sapiens(human) -> NP_001408.2 Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 2, mRNA.

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CloneID	OHu108375
Clone ID Related Accession (Same CDS sequence)	NM_001417.7
Accession Version	NM_001417.7 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1836bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 4B isoform 2
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. This record has been curated by NCBI staff in collaboration with Francesco Amaldi. The reference sequence was derived from AC068888.35. On Jun 2, 2019 this sequence version replaced NM_001417.6. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.19838.1, SRR1803614.213627.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCCT CAGCAAAAAA GAAGAATAAG AAGGGGAAGA CTATCTCCCT AACAGACTTT 
CTGGCTGAGG ATGGGGGTAC TGGTGGAGGA AGCACCTATG TTTCCAAACC AGTCAGCTGG 
GCTGATGAAA CGGATGACCT GGAAGGAGAT GTTTCGACCA CTTGGCACAG TAACGATGAC 
GATGTGTATA GGGCGCCTCC AATTGACCGT TCCATCCTTC CCACTGCTCC ACGGGCTGCT 
CGGGAACCCA ATATCGACCG GAGCCGTCTT CCCAAATCGC CACCCTACAC TGCTTTTCTA 
GGAAACCTAC CCTATGATGT TACAGAAGAG TCAATTAAGG AATTCTTTCG AGGATTAAAT 
ATCAGTGCAG TGCGTTTACC ACGTGAACCC AGCAATCCAG AGAGGTTGAA AGGTTTTGGT 
TATGCTGAAT TTGAGGACCT GGATTCCCTG CTCAGTGCCC TGAGTCTCAA TGAAGAGTCT 
CTAGGTAACA GGAGAATTCG AGTGGACGTT GCTGATCAAG CACAGGATAA AGACAGGGAT 
GATCGTTCTT TTGGCCGTGA TAGAAATCGG GATTCTGACA AAACAGATAC AGACTGGAGG 
GCTCGTCCTG CTACAGACAG CTTTGATGAC TACCCACCTA GAAGAGGTGA TGATAGCTTT 
GGAGACAAGT ATCGAGATCG TTATGATTCA GACCGGTATC GGGATGGGTA TCGGGATGGG 
TATCGGGATG GCCCACGCCG GGATATGGAT CGATATGGTG GCCGGGATCG CTATGATGAC 
CGAGGCAGCA GAGACTATGA TAGAGGCTAT GATTCCCGGA TAGGCAGTGG CAGAAGAGCA 
TTTGGCAGTG GGTATCGCAG GGATGATGAC TACAGAGGAG GCGGGGACCG CTATGAAGAC 
CGATATGACA GACGGGATGA TCGGTCGTGG AGCTCCAGAG ATGATTACTC TCGGGATGAT 
TATAGGCGTG ATGATAGAGG TCCCCCCCAA AGACCCAAAC TGAATCTAAA GCCTCGGAGT 
ACTCCTAAGG AAGATGATTC CTCTGCTAGT ACCTCCCAGT CCACTCGAGC TGCTTCTATC 
TTTGGAGGGG CAAAGCCTGT TGACACAGCT GCTAGAGAAA GAGAAGTAGA AGAACGGCTA 
CAGAAGGAAC AAGAGAAGTT GCAGCGTCAG CTGGATGAGC CAAAACTAGA ACGACGGCCT 
CGGGAGAGAC ACCCAAGCTG GCGAAGTGAA GAAACTCAGG AACGGGAACG GTCGAGGACA 
GGAAGTGAGT CATCACAAAC TGGGACCTCC ACCACATCTA GCAGAAATGC ACGAAGGAGA 
GAGAGTGAGA AGTCTCTAGA AAATGAAACA CTCAATAAGG AGGAAGATTG CCACTCTCCA 
ACTTCTAAAC CTCCCAAACC TGATCAGCCC CTAAAGGTAA TGCCAGCCCC TCCACCAAAG 
GAGAATGCTT GGGTGAAGCG AAGTTCTAAC CCTCCTGCTC GATCTCAGAG CTCAGACACA 
GAGCAGCAGT CCCCTACAAG TGGTGGGGGA AAAGTAGCTC CAGCTCAACC ATCTGAGGAA 
GGACCAGGAA GGAAAGATGA AAATAAAGTA GATGGGATGA ATGCCCCAAA AGGCCAAACT 
GGGAACTCTA GCCGTGGTCC AGGCGACGGA GGGAACAGAG ACCACTGGAA GGAGTCAGAT 
AGGAAAGATG GCAAAAAGGA TCAAGACTCC AGATCTGCAC CTGAGCCAAA GAAACCTGAG 
GAAAATCCAG CTTCCAAGTT CAGTTCTGCA AGCAAGTATG CTGCTCTCTC TGTTGATGGT 
GAAGATGAAA ATGAGGGAGA AGATTATGCC GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001408.2
CDS	29..1864
Translation	MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSRNARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE

Target ORF information:

RefSeq Version	NM_001417.7
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001417.7

ORF Insert Sequence:

ATGGCGGCCT CAGCAAAAAA GAAGAATAAG AAGGGGAAGA CTATCTCCCT AACAGACTTT 
CTGGCTGAGG ATGGGGGTAC TGGTGGAGGA AGCACCTATG TTTCCAAACC AGTCAGCTGG 
GCTGATGAAA CGGATGACCT GGAAGGAGAT GTTTCGACCA CTTGGCACAG TAACGATGAC 
GATGTGTATA GGGCGCCTCC AATTGACCGT TCCATCCTTC CCACTGCTCC ACGGGCTGCT 
CGGGAACCCA ATATCGACCG GAGCCGTCTT CCCAAATCGC CACCCTACAC TGCTTTTCTA 
GGAAACCTAC CCTATGATGT TACAGAAGAG TCAATTAAGG AATTCTTTCG AGGATTAAAT 
ATCAGTGCAG TGCGTTTACC ACGTGAACCC AGCAATCCAG AGAGGTTGAA AGGTTTTGGT 
TATGCTGAAT TTGAGGACCT GGATTCCCTG CTCAGTGCCC TGAGTCTCAA TGAAGAGTCT 
CTAGGTAACA GGAGAATTCG AGTGGACGTT GCTGATCAAG CACAGGATAA AGACAGGGAT 
GATCGTTCTT TTGGCCGTGA TAGAAATCGG GATTCTGACA AAACAGATAC AGACTGGAGG 
GCTCGTCCTG CTACAGACAG CTTTGATGAC TACCCACCTA GAAGAGGTGA TGATAGCTTT 
GGAGACAAGT ATCGAGATCG TTATGATTCA GACCGGTATC GGGATGGGTA TCGGGATGGG 
TATCGGGATG GCCCACGCCG GGATATGGAT CGATATGGTG GCCGGGATCG CTATGATGAC 
CGAGGCAGCA GAGACTATGA TAGAGGCTAT GATTCCCGGA TAGGCAGTGG CAGAAGAGCA 
TTTGGCAGTG GGTATCGCAG GGATGATGAC TACAGAGGAG GCGGGGACCG CTATGAAGAC 
CGATATGACA GACGGGATGA TCGGTCGTGG AGCTCCAGAG ATGATTACTC TCGGGATGAT 
TATAGGCGTG ATGATAGAGG TCCCCCCCAA AGACCCAAAC TGAATCTAAA GCCTCGGAGT 
ACTCCTAAGG AAGATGATTC CTCTGCTAGT ACCTCCCAGT CCACTCGAGC TGCTTCTATC 
TTTGGAGGGG CAAAGCCTGT TGACACAGCT GCTAGAGAAA GAGAAGTAGA AGAACGGCTA 
CAGAAGGAAC AAGAGAAGTT GCAGCGTCAG CTGGATGAGC CAAAACTAGA ACGACGGCCT 
CGGGAGAGAC ACCCAAGCTG GCGAAGTGAA GAAACTCAGG AACGGGAACG GTCGAGGACA 
GGAAGTGAGT CATCACAAAC TGGGACCTCC ACCACATCTA GCAGAAATGC ACGAAGGAGA 
GAGAGTGAGA AGTCTCTAGA AAATGAAACA CTCAATAAGG AGGAAGATTG CCACTCTCCA 
ACTTCTAAAC CTCCCAAACC TGATCAGCCC CTAAAGGTAA TGCCAGCCCC TCCACCAAAG 
GAGAATGCTT GGGTGAAGCG AAGTTCTAAC CCTCCTGCTC GATCTCAGAG CTCAGACACA 
GAGCAGCAGT CCCCTACAAG TGGTGGGGGA AAAGTAGCTC CAGCTCAACC ATCTGAGGAA 
GGACCAGGAA GGAAAGATGA AAATAAAGTA GATGGGATGA ATGCCCCAAA AGGCCAAACT 
GGGAACTCTA GCCGTGGTCC AGGCGACGGA GGGAACAGAG ACCACTGGAA GGAGTCAGAT 
AGGAAAGATG GCAAAAAGGA TCAAGACTCC AGATCTGCAC CTGAGCCAAA GAAACCTGAG 
GAAAATCCAG CTTCCAAGTT CAGTTCTGCA AGCAAGTATG CTGCTCTCTC TGTTGATGGT 
GAAGATGAAA ATGAGGGAGA AGATTATGCC GAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EIF4B ( NM_001330654.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001317583.1 Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu108383
Clone ID Related Accession (Same CDS sequence)	NM_001330654.2
Accession Version	NM_001330654.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1719bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-07
Organism	Homo sapiens(human)
Product	eukaryotic translation initiation factor 4B isoform 3
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC068888.35. On Jun 2, 2019 this sequence version replaced NM_001330654.1. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK299526.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1968968 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGGCCT CAGCAAAAAA GAAGAATAAG AAGGGGAAGA CTATCTCCCT AACAGACTTT 
CTGGCTGAGG ATGGGGGTAC TGGTGGAGGA AGCACCTATG TTTCCAAACC AGTCAGCTGG 
GCTGATGAAA CGGATGACCT GGAAGGAGAT GTTTCGACCA CTTGGCACAG TAACGATGAC 
GATGTGTATA GGGCGCCTCC AATTGACCGT TCCATCCTTC CCACTGCTCC ACGGGCTGCT 
CGGGAACCCA ATATCGACCG GAGCCGTCTT CCCAAATCGC CACCCTACAC TGCTTTTCTA 
GGAAACCTAC CCTATGATGT TACAGAAGAG TCAATTAAGG AATTCTTTCG AGGATTAAAT 
TCTCTAGGTA ACAGGAGAAT TCGAGTGGAC GTTGCTGATC AAGCACAGGA TAAAGACAGG 
GATGATCGTT CTTTTGGCCG TGATAGAAAT CGGGATTCTG ACAAAACAGA TACAGACTGG 
AGGGCTCGTC CTGCTACAGA CAGCTTTGAT GACTACCCAC CTAGAAGAGG TGATGATAGC 
TTTGGAGACA AGTATCGAGA TCGTTATGAT TCAGACCGGT ATCGGGATGG GTATCGGGAT 
GGGTATCGGG ATGGCCCACG CCGGGATATG GATCGATATG GTGGCCGGGA TCGCTATGAT 
GACCGAGGCA GCAGAGACTA TGATAGAGGC TATGATTCCC GGATAGGCAG TGGCAGAAGA 
GCATTTGGCA GTGGGTATCG CAGGGATGAT GACTACAGAG GAGGCGGGGA CCGCTATGAA 
GACCGATATG ACAGACGGGA TGATCGGTCG TGGAGCTCCA GAGATGATTA CTCTCGGGAT 
GATTATAGGC GTGATGATAG AGGTCCCCCC CAAAGACCCA AACTGAATCT AAAGCCTCGG 
AGTACTCCTA AGGAAGATGA TTCCTCTGCT AGTACCTCCC AGTCCACTCG AGCTGCTTCT 
ATCTTTGGAG GGGCAAAGCC TGTTGACACA GCTGCTAGAG AAAGAGAAGT AGAAGAACGG 
CTACAGAAGG AACAAGAGAA GTTGCAGCGT CAGCTGGATG AGCCAAAACT AGAACGACGG 
CCTCGGGAGA GACACCCAAG CTGGCGAAGT GAAGAAACTC AGGAACGGGA ACGGTCGAGG 
ACAGGAAGTG AGTCATCACA AACTGGGACC TCCACCACAT CTAGCAGAAA TGCACGAAGG 
AGAGAGAGTG AGAAGTCTCT AGAAAATGAA ACACTCAATA AGGAGGAAGA TTGCCACTCT 
CCAACTTCTA AACCTCCCAA ACCTGATCAG CCCCTAAAGG TAATGCCAGC CCCTCCACCA 
AAGGAGAATG CTTGGGTGAA GCGAAGTTCT AACCCTCCTG CTCGATCTCA GAGCTCAGAC 
ACAGAGCAGC AGTCCCCTAC AAGTGGTGGG GGAAAAGTAG CTCCAGCTCA ACCATCTGAG 
GAAGGACCAG GAAGGAAAGA TGAAAATAAA GTAGATGGGA TGAATGCCCC AAAAGGCCAA 
ACTGGGAACT CTAGCCGTGG TCCAGGCGAC GGAGGGAACA GAGACCACTG GAAGGAGTCA 
GATAGGAAAG ATGGCAAAAA GGATCAAGAC TCCAGATCTG CACCTGAGCC AAAGAAACCT 
GAGGAAAATC CAGCTTCCAA GTTCAGTTCT GCAAGCAAGT ATGCTGCTCT CTCTGTTGAT 
GGTGAAGATG AAAATGAGGG AGAAGATTAT GCCGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001317583.1
CDS	29..1747
Translation	MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNSLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSRNARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE

Target ORF information:

RefSeq Version	NM_001330654.2
Organism	Homo sapiens(human)
Definition	Homo sapiens eukaryotic translation initiation factor 4B (EIF4B), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001330654.2

ORF Insert Sequence:

ATGGCGGCCT CAGCAAAAAA GAAGAATAAG AAGGGGAAGA CTATCTCCCT AACAGACTTT 
CTGGCTGAGG ATGGGGGTAC TGGTGGAGGA AGCACCTATG TTTCCAAACC AGTCAGCTGG 
GCTGATGAAA CGGATGACCT GGAAGGAGAT GTTTCGACCA CTTGGCACAG TAACGATGAC 
GATGTGTATA GGGCGCCTCC AATTGACCGT TCCATCCTTC CCACTGCTCC ACGGGCTGCT 
CGGGAACCCA ATATCGACCG GAGCCGTCTT CCCAAATCGC CACCCTACAC TGCTTTTCTA 
GGAAACCTAC CCTATGATGT TACAGAAGAG TCAATTAAGG AATTCTTTCG AGGATTAAAT 
TCTCTAGGTA ACAGGAGAAT TCGAGTGGAC GTTGCTGATC AAGCACAGGA TAAAGACAGG 
GATGATCGTT CTTTTGGCCG TGATAGAAAT CGGGATTCTG ACAAAACAGA TACAGACTGG 
AGGGCTCGTC CTGCTACAGA CAGCTTTGAT GACTACCCAC CTAGAAGAGG TGATGATAGC 
TTTGGAGACA AGTATCGAGA TCGTTATGAT TCAGACCGGT ATCGGGATGG GTATCGGGAT 
GGGTATCGGG ATGGCCCACG CCGGGATATG GATCGATATG GTGGCCGGGA TCGCTATGAT 
GACCGAGGCA GCAGAGACTA TGATAGAGGC TATGATTCCC GGATAGGCAG TGGCAGAAGA 
GCATTTGGCA GTGGGTATCG CAGGGATGAT GACTACAGAG GAGGCGGGGA CCGCTATGAA 
GACCGATATG ACAGACGGGA TGATCGGTCG TGGAGCTCCA GAGATGATTA CTCTCGGGAT 
GATTATAGGC GTGATGATAG AGGTCCCCCC CAAAGACCCA AACTGAATCT AAAGCCTCGG 
AGTACTCCTA AGGAAGATGA TTCCTCTGCT AGTACCTCCC AGTCCACTCG AGCTGCTTCT 
ATCTTTGGAG GGGCAAAGCC TGTTGACACA GCTGCTAGAG AAAGAGAAGT AGAAGAACGG 
CTACAGAAGG AACAAGAGAA GTTGCAGCGT CAGCTGGATG AGCCAAAACT AGAACGACGG 
CCTCGGGAGA GACACCCAAG CTGGCGAAGT GAAGAAACTC AGGAACGGGA ACGGTCGAGG 
ACAGGAAGTG AGTCATCACA AACTGGGACC TCCACCACAT CTAGCAGAAA TGCACGAAGG 
AGAGAGAGTG AGAAGTCTCT AGAAAATGAA ACACTCAATA AGGAGGAAGA TTGCCACTCT 
CCAACTTCTA AACCTCCCAA ACCTGATCAG CCCCTAAAGG TAATGCCAGC CCCTCCACCA 
AAGGAGAATG CTTGGGTGAA GCGAAGTTCT AACCCTCCTG CTCGATCTCA GAGCTCAGAC 
ACAGAGCAGC AGTCCCCTAC AAGTGGTGGG GGAAAAGTAG CTCCAGCTCA ACCATCTGAG 
GAAGGACCAG GAAGGAAAGA TGAAAATAAA GTAGATGGGA TGAATGCCCC AAAAGGCCAA 
ACTGGGAACT CTAGCCGTGG TCCAGGCGAC GGAGGGAACA GAGACCACTG GAAGGAGTCA 
GATAGGAAAG ATGGCAAAAA GGATCAAGAC TCCAGATCTG CACCTGAGCC AAAGAAACCT 
GAGGAAAATC CAGCTTCCAA GTTCAGTTCT GCAAGCAAGT ATGCTGCTCT CTCTGTTGAT 
GGTGAAGATG AAAATGAGGG AGAAGATTAT GCCGAATAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pim-2 Cooperates with Downstream Factor XIAP to Inhibit Apoptosis and Intensify Malignant Grade in Prostate Cancer.
Pathology oncology research : POR(2017 Nov)
Ren K,Gou X,Xiao M,He W,Kang J

Muscarinic acetylcholine receptors mediate eIF4B phosphorylation in SNU-407 colon cancer cells.
Biochemical and biophysical research communications480(3)450-454(2016 Nov)
Liu Z,Cho NJ

Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.
Proceedings of the National Academy of Sciences of the United States of America113(35)9810-5(2016 08)
Wang Y,Begley M,Li Q,Huang HT,Lako A,Eck MJ,Gray NS,Mitchison TJ,Cantley LC,Zhao JJ

eIF4B is a convergent target and critical effector of oncogenic Pim and PI3K/Akt/mTOR signaling pathways in Abl transformants.
Oncotarget7(9)10073-89(2016 Mar)
Chen K,Yang J,Li J,Wang X,Chen Y,Huang S,Chen JL

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EIF4B cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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