EFNA2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	EFNA2
Entrez Gene ID	1943
Full Name	ephrin A2
Synonyms	ELF-1,EPLG6,HEK7-L,LERK-6,LERK6
General protein information	Preferred Names ephrin A2 Names ephrin-A2 HEK7 ligand eph-related receptor tyrosine kinase ligand 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008].
Disorder MIM:	602756

mRNA and Protein(s)

mRNA	Protein	Name
NM_001405.4	NP_001396.2	ephrin-A2 precursor
XM_017026450.1	XP_016881939.1	ephrin-A2 isoform X2
NM_001405.3	NP_001396.2	ephrin-A2 precursor
XM_017026449.1	XP_016881938.1	ephrin-A2 isoform X1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	EFNA2	XP_001172483.1
Bos taurus (cattle)	EFNA2	NP_001098470.1
Rattus norvegicus (Norway rat)	Efna2	NP_001162141.1
Danio rerio (zebrafish)	LOC100332852	XP_002663773.1
Homo sapiens (human)	EFNA2	NP_001396.2
Mus musculus (house mouse)	Efna2	NP_031935.3
Gallus gallus (chicken)	EFNA2	NP_990314.1
Danio rerio (zebrafish)	efna2	NP_571097.1
	LOC721231	XP_001117318.1
Xenopus tropicalis (tropical clawed frog)	efna2	NP_001116892.1

Gene Ontology
Bibliography

Related articles in PubMed

Diagnostic and prognostic value of tissue and circulating levels of Ephrin-A2 in prostate cancer.
Li S, Wu Z, Chen Y, Kang Z, Wang H, He P, Zhang X, Hu T, Zhang Q, Cai Y, Xu X, Guan M
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(4)5365-74(2016 Apr)

CIB1 synergizes with EphrinA2 to regulate Kaposi's sarcoma-associated herpesvirus macropinocytic entry in human microvascular dermal endothelial cells.
Bandyopadhyay C, Valiya-Veettil M, Dutta D, Chakraborty S, Chandran B
PLoS pathogens10(2)e1003941(2014 Feb)

The prognostic role of ephrin A2 and endothelial growth factor receptor pathway mediators in patients with advanced colorectal cancer treated with cetuximab.
Strimpakos A, Pentheroudakis G, Kotoula V, De Roock W, Kouvatseas G, Papakostas P, Makatsoris T, Papamichael D, Andreadou A, Sgouros J, Zizi-Sermpetzoglou A, Kominea A, Televantou D, Razis E, Galani E, Pectasides D, Tejpar S, Syrigos K, Fountzilas G
Clinical colorectal cancer12(4)267-274.e2(2013 Dec)

EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis.
Funk SD, Yurdagul A Jr, Albert P, Traylor JG Jr, Jin L, Chen J, Orr AW
Arteriosclerosis, thrombosis, and vascular biology32(3)686-95(2012 Mar)

The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction.
Goichberg P, Bai Y, D'Amario D, Ferreira-Martins J, Fiorini C, Zheng H, Signore S, del Monte F, Ottolenghi S, D'Alessandro DA, Michler RE, Hosoda T, Anversa P, Kajstura J, Rota M, Leri A
Circulation research108(9)1071-83(2011 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Ephrin-A2 expression was correlated with Ki-67 expression in PCa patients, both at the gene scale and protein level. Our data indicate that Ephrin-A2 is a potential diagnostic and prognostic biomarker and a promising molecular therapeutic target to attenuate prostate cancer progression
Title: Diagnostic and prognostic value of tissue and circulating levels of Ephrin-A2 in prostate cancer.

these studies suggested that Kaposi's sarcoma-associated herpesvirus utilizes CIB1 as one of the key molecule(s) to coordinate and sustain the EphA2 mediated signaling involved in its entry
Title: CIB1 synergizes with EphrinA2 to regulate Kaposi's sarcoma-associated herpesvirus macropinocytic entry in human microvascular dermal endothelial cells.

High EphA2 receptor expression in colorectal cancer was associated with a worse outcome in patients treated with cetuximab-based therapy
Title: The prognostic role of ephrin A2 and endothelial growth factor receptor pathway mediators in patients with advanced colorectal cancer treated with cetuximab.

Implicate EphA2 as a novel proinflammatory mediator and potential regulator of atherosclerotic plaque development.
Title: EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis.

Ephrin A1 promotes the motility of EphA2-positive cardiac stem cells, facilitates their migration to the area of damage, and enhances cardiac repair
Title: The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction.

The following EFNA2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the EFNA2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01272	NM_001405.4 Latest version!	Homo sapiens ephrin A2 (EFNA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu88294	XM_017026449.1 Latest version!	Homo sapiens ephrin A2 (EFNA2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu88295	XM_017026450.1 Latest version!	Homo sapiens ephrin A2 (EFNA2), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
View Old Accession Versions >>
OHu01272	NM_001405.3	Homo sapiens ephrin A2 (EFNA2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$69.30 $99.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

EFNA2 ( NM_001405.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001396.2 Homo sapiens ephrin A2 (EFNA2), mRNA.

Price & Availability↑

CloneID	OHu01272
Clone ID Related Accession (Same CDS sequence)	NM_001405.4 , NM_001405.3
Accession Version	NM_001405.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-14
Organism	Homo sapiens(human)
Product	ephrin-A2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004258.1. On Nov 23, 2018 this sequence version replaced NM_001405.3. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ007292.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000215368.4/ ENSP00000215368.1 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGCCCG CGCAGCGCCC GCTGCTCCCG CTGCTGCTCC TGCTGTTACC GCTGCCGCCG 
CCGCCCTTCG CGCGCGCCGA GGACGCCGCC CGCGCCAACT CGGACCGCTA CGCCGTCTAC 
TGGAACCGCA GCAACCCCAG GTTCCACGCA GGCGCGGGGG ACGACGGCGG GGGCTACACG 
GTGGAGGTGA GCATCAATGA CTACCTGGAC ATCTACTGCC CGCACTATGG GGCGCCGCTG 
CCGCCGGCCG AGCGCATGGA GCACTACGTG CTGTACATGG TCAACGGCGA GGGCCACGCC 
TCCTGCGACC ACCGCCAGCG CGGCTTCAAG CGCTGGGAGT GCAACCGGCC CGCGGCGCCC 
GGGGGGCCGC TCAAGTTCTC GGAGAAGTTC CAGCTCTTCA CGCCCTTCTC CCTGGGCTTC 
GAGTTCCGGC CCGGCCACGA GTATTACTAC ATCTCTGCCA CGCCTCCCAA TGCTGTGGAC 
CGGCCCTGCC TGCGACTGAA GGTGTACGTG CGGCCGACCA ACGAGACCCT GTACGAGGCT 
CCTGAGCCCA TCTTCACCAG CAATAACTCG TGTAGCAGCC CGGGCGGCTG CCGCCTCTTC 
CTCAGCACCA TCCCCGTGCT CTGGACCCTC CTGGGTTCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001396.2
CDS	297..938
Translation	MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS

Target ORF information:

RefSeq Version	NM_001405.4
Organism	Homo sapiens(human)
Definition	Homo sapiens ephrin A2 (EFNA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001405.4

ORF Insert Sequence:

ATGGCGCCCG CGCAGCGCCC GCTGCTCCCG CTGCTGCTCC TGCTGTTACC GCTGCCGCCG 
CCGCCCTTCG CGCGCGCCGA GGACGCCGCC CGCGCCAACT CGGACCGCTA CGCCGTCTAC 
TGGAACCGCA GCAACCCCAG GTTCCACGCA GGCGCGGGGG ACGACGGCGG GGGCTACACG 
GTGGAGGTGA GCATCAATGA CTACCTGGAC ATCTACTGCC CGCACTATGG GGCGCCGCTG 
CCGCCGGCCG AGCGCATGGA GCACTACGTG CTGTACATGG TCAACGGCGA GGGCCACGCC 
TCCTGCGACC ACCGCCAGCG CGGCTTCAAG CGCTGGGAGT GCAACCGGCC CGCGGCGCCC 
GGGGGGCCGC TCAAGTTCTC GGAGAAGTTC CAGCTCTTCA CGCCCTTCTC CCTGGGCTTC 
GAGTTCCGGC CCGGCCACGA GTATTACTAC ATCTCTGCCA CGCCTCCCAA TGCTGTGGAC 
CGGCCCTGCC TGCGACTGAA GGTGTACGTG CGGCCGACCA ACGAGACCCT GTACGAGGCT 
CCTGAGCCCA TCTTCACCAG CAATAACTCG TGTAGCAGCC CGGGCGGCTG CCGCCTCTTC 
CTCAGCACCA TCCCCGTGCT CTGGACCCTC CTGGGTTCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EFNA2 ( NM_001405.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001396.2 Homo sapiens ephrin A2 (EFNA2), mRNA.

Price & Availability↑

CloneID	OHu01272
Clone ID Related Accession (Same CDS sequence)	NM_001405.4 , NM_001405.3
Accession Version	NM_001405.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 642bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	ephrin-A2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004258.1. On or before Jul 1, 2011 this sequence version replaced XR_115223.1, XR_109551.1, XR_111809.1, NM_001405.2. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AJ007292.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCGCCCG CGCAGCGCCC GCTGCTCCCG CTGCTGCTCC TGCTGTTACC GCTGCCGCCG 
CCGCCCTTCG CGCGCGCCGA GGACGCCGCC CGCGCCAACT CGGACCGCTA CGCCGTCTAC 
TGGAACCGCA GCAACCCCAG GTTCCACGCA GGCGCGGGGG ACGACGGCGG GGGCTACACG 
GTGGAGGTGA GCATCAATGA CTACCTGGAC ATCTACTGCC CGCACTATGG GGCGCCGCTG 
CCGCCGGCCG AGCGCATGGA GCACTACGTG CTGTACATGG TCAACGGCGA GGGCCACGCC 
TCCTGCGACC ACCGCCAGCG CGGCTTCAAG CGCTGGGAGT GCAACCGGCC CGCGGCGCCC 
GGGGGGCCGC TCAAGTTCTC GGAGAAGTTC CAGCTCTTCA CGCCCTTCTC CCTGGGCTTC 
GAGTTCCGGC CCGGCCACGA GTATTACTAC ATCTCTGCCA CGCCTCCCAA TGCTGTGGAC 
CGGCCCTGCC TGCGACTGAA GGTGTACGTG CGGCCGACCA ACGAGACCCT GTACGAGGCT 
CCTGAGCCCA TCTTCACCAG CAATAACTCG TGTAGCAGCC CGGGCGGCTG CCGCCTCTTC 
CTCAGCACCA TCCCCGTGCT CTGGACCCTC CTGGGTTCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001396.2
CDS	16..657
Translation	MAPAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS

Target ORF information:

RefSeq Version	NM_001405.3
Organism	Homo sapiens(human)
Definition	Homo sapiens ephrin A2 (EFNA2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001405.3

ORF Insert Sequence:

ATGGCGCCCG CGCAGCGCCC GCTGCTCCCG CTGCTGCTCC TGCTGTTACC GCTGCCGCCG 
CCGCCCTTCG CGCGCGCCGA GGACGCCGCC CGCGCCAACT CGGACCGCTA CGCCGTCTAC 
TGGAACCGCA GCAACCCCAG GTTCCACGCA GGCGCGGGGG ACGACGGCGG GGGCTACACG 
GTGGAGGTGA GCATCAATGA CTACCTGGAC ATCTACTGCC CGCACTATGG GGCGCCGCTG 
CCGCCGGCCG AGCGCATGGA GCACTACGTG CTGTACATGG TCAACGGCGA GGGCCACGCC 
TCCTGCGACC ACCGCCAGCG CGGCTTCAAG CGCTGGGAGT GCAACCGGCC CGCGGCGCCC 
GGGGGGCCGC TCAAGTTCTC GGAGAAGTTC CAGCTCTTCA CGCCCTTCTC CCTGGGCTTC 
GAGTTCCGGC CCGGCCACGA GTATTACTAC ATCTCTGCCA CGCCTCCCAA TGCTGTGGAC 
CGGCCCTGCC TGCGACTGAA GGTGTACGTG CGGCCGACCA ACGAGACCCT GTACGAGGCT 
CCTGAGCCCA TCTTCACCAG CAATAACTCG TGTAGCAGCC CGGGCGGCTG CCGCCTCTTC 
CTCAGCACCA TCCCCGTGCT CTGGACCCTC CTGGGTTCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EFNA2 ( XM_017026449.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881938.1 Homo sapiens ephrin A2 (EFNA2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu88294
Clone ID Related Accession (Same CDS sequence)	XM_017026449.1
Accession Version	XM_017026449.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 897bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ephrin-A2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGACCTG GAGCTCAGAA CAGACGGGCT GAGCTCCCTG GAGGAGAGAG AACTGAGAAC 
CTTGTCCTGG CAGGGACGCT AGAGCACTGG GTGGGACAGA CCTTTCTGGA AGAGCAAGAT 
TTTAACAGGA AGAAAAAGTG GAAGGACTTC CCAGCAGGAC CCAGCCTGAA CAAAGGTCAG 
GTGGTGTGGC CCGCGTGGCC CGCTGGGGAA TCGGGGGAGG AGGGCACGCA GGAGACACAG 
GACAGAGCCC ACCACGTCTC AGAGCTGTGG GACGGTGGTG GGTCCGGTCC CCACCCCACC 
TTGCTGGGGC ACAGGGAGAC TGGAGTTGGC CGAGCCCGAT TTGGGACGCG TGCGTCGGGG 
TTGGTGAGGC TGCGGATAGC GCTGGAACCG GGCAGGTTCC ACGCAGGCGC GGGGGACGAC 
GGCGGGGGCT ACACGGTGGA GGTGAGCATC AATGACTACC TGGACATCTA CTGCCCGCAC 
TATGGGGCGC CGCTGCCGCC GGCCGAGCGC ATGGAGCACT ACGTGCTGTA CATGGTCAAC 
GGCGAGGGCC ACGCCTCCTG CGACCACCGC CAGCGCGGCT TCAAGCGCTG GGAGTGCAAC 
CGGCCCGCGG CGCCCGGGGG GCCGCTCAAG TTCTCGGAGA AGTTCCAGCT CTTCACGCCC 
TTCTCCCTGG GCTTCGAGTT CCGGCCCGGC CACGAGTATT ACTACATCTC TGCCACGCCT 
CCCAATGCTG TGGACCGGCC CTGCCTGCGA CTGAAGGTGT ACGTGCGGCC GACCAACGAG 
ACCCTGTACG AGGCTCCTGA GCCCATCTTC ACCAGCAATA ACTCGTGTAG CAGCCCGGGC 
GGCTGCCGCC TCTTCCTCAG CACCATCCCC GTGCTCTGGA CCCTCCTGGG TTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881938.1
CDS	1566..2462
Translation	MRPGAQNRRAELPGGERTENLVLAGTLEHWVGQTFLEEQDFNRKKKWKDFPAGPSLNKGQVVWPAWPAGESGEEGTQETQDRAHHVSELWDGGGSGPHPTLLGHRETGVGRARFGTRASGLVRLRIALEPGRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS

Target ORF information:

RefSeq Version	XM_017026449.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ephrin A2 (EFNA2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026449.1

ORF Insert Sequence:

ATGAGACCTG GAGCTCAGAA CAGACGGGCT GAGCTCCCTG GAGGAGAGAG AACTGAGAAC 
CTTGTCCTGG CAGGGACGCT AGAGCACTGG GTGGGACAGA CCTTTCTGGA AGAGCAAGAT 
TTTAACAGGA AGAAAAAGTG GAAGGACTTC CCAGCAGGAC CCAGCCTGAA CAAAGGTCAG 
GTGGTGTGGC CCGCGTGGCC CGCTGGGGAA TCGGGGGAGG AGGGCACGCA GGAGACACAG 
GACAGAGCCC ACCACGTCTC AGAGCTGTGG GACGGTGGTG GGTCCGGTCC CCACCCCACC 
TTGCTGGGGC ACAGGGAGAC TGGAGTTGGC CGAGCCCGAT TTGGGACGCG TGCGTCGGGG 
TTGGTGAGGC TGCGGATAGC GCTGGAACCG GGCAGGTTCC ACGCAGGCGC GGGGGACGAC 
GGCGGGGGCT ACACGGTGGA GGTGAGCATC AATGACTACC TGGACATCTA CTGCCCGCAC 
TATGGGGCGC CGCTGCCGCC GGCCGAGCGC ATGGAGCACT ACGTGCTGTA CATGGTCAAC 
GGCGAGGGCC ACGCCTCCTG CGACCACCGC CAGCGCGGCT TCAAGCGCTG GGAGTGCAAC 
CGGCCCGCGG CGCCCGGGGG GCCGCTCAAG TTCTCGGAGA AGTTCCAGCT CTTCACGCCC 
TTCTCCCTGG GCTTCGAGTT CCGGCCCGGC CACGAGTATT ACTACATCTC TGCCACGCCT 
CCCAATGCTG TGGACCGGCC CTGCCTGCGA CTGAAGGTGT ACGTGCGGCC GACCAACGAG 
ACCCTGTACG AGGCTCCTGA GCCCATCTTC ACCAGCAATA ACTCGTGTAG CAGCCCGGGC 
GGCTGCCGCC TCTTCCTCAG CACCATCCCC GTGCTCTGGA CCCTCCTGGG TTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

EFNA2 ( XM_017026450.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016881939.1 Homo sapiens ephrin A2 (EFNA2), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu88295
Clone ID Related Accession (Same CDS sequence)	XM_017026450.1
Accession Version	XM_017026450.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 609bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	ephrin-A2 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000019.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGCTCCCGG CACCCTTAGG GCTGAGGGAG ACTGGAGTTG GCCGAGCCCG ATTTGGGACG 
CGTGCGTCGG GGTTGGTGAG GCTGCGGATA GCGCTGGAAC CGGGCAGGTT CCACGCAGGC 
GCGGGGGACG ACGGCGGGGG CTACACGGTG GAGGTGAGCA TCAATGACTA CCTGGACATC 
TACTGCCCGC ACTATGGGGC GCCGCTGCCG CCGGCCGAGC GCATGGAGCA CTACGTGCTG 
TACATGGTCA ACGGCGAGGG CCACGCCTCC TGCGACCACC GCCAGCGCGG CTTCAAGCGC 
TGGGAGTGCA ACCGGCCCGC GGCGCCCGGG GGGCCGCTCA AGTTCTCGGA GAAGTTCCAG 
CTCTTCACGC CCTTCTCCCT GGGCTTCGAG TTCCGGCCCG GCCACGAGTA TTACTACATC 
TCTGCCACGC CTCCCAATGC TGTGGACCGG CCCTGCCTGC GACTGAAGGT GTACGTGCGG 
CCGACCAACG AGACCCTGTA CGAGGCTCCT GAGCCCATCT TCACCAGCAA TAACTCGTGT 
AGCAGCCCGG GCGGCTGCCG CCTCTTCCTC AGCACCATCC CCGTGCTCTG GACCCTCCTG 
GGTTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016881939.1
CDS	738..1346
Translation	MLPAPLGLRETGVGRARFGTRASGLVRLRIALEPGRFHAGAGDDGGGYTVEVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPGGPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKVYVRPTNETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS

Target ORF information:

RefSeq Version	XM_017026450.1
Organism	Homo sapiens(human)
Definition	Homo sapiens ephrin A2 (EFNA2), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017026450.1

ORF Insert Sequence:

ATGCTCCCGG CACCCTTAGG GCTGAGGGAG ACTGGAGTTG GCCGAGCCCG ATTTGGGACG 
CGTGCGTCGG GGTTGGTGAG GCTGCGGATA GCGCTGGAAC CGGGCAGGTT CCACGCAGGC 
GCGGGGGACG ACGGCGGGGG CTACACGGTG GAGGTGAGCA TCAATGACTA CCTGGACATC 
TACTGCCCGC ACTATGGGGC GCCGCTGCCG CCGGCCGAGC GCATGGAGCA CTACGTGCTG 
TACATGGTCA ACGGCGAGGG CCACGCCTCC TGCGACCACC GCCAGCGCGG CTTCAAGCGC 
TGGGAGTGCA ACCGGCCCGC GGCGCCCGGG GGGCCGCTCA AGTTCTCGGA GAAGTTCCAG 
CTCTTCACGC CCTTCTCCCT GGGCTTCGAG TTCCGGCCCG GCCACGAGTA TTACTACATC 
TCTGCCACGC CTCCCAATGC TGTGGACCGG CCCTGCCTGC GACTGAAGGT GTACGTGCGG 
CCGACCAACG AGACCCTGTA CGAGGCTCCT GAGCCCATCT TCACCAGCAA TAACTCGTGT 
AGCAGCCCGG GCGGCTGCCG CCTCTTCCTC AGCACCATCC CCGTGCTCTG GACCCTCCTG 
GGTTCCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Diagnostic and prognostic value of tissue and circulating levels of Ephrin-A2 in prostate cancer.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine37(4)5365-74(2016 Apr)
Li S,Wu Z,Chen Y,Kang Z,Wang H,He P,Zhang X,Hu T,Zhang Q,Cai Y,Xu X,Guan M

CIB1 synergizes with EphrinA2 to regulate Kaposi's sarcoma-associated herpesvirus macropinocytic entry in human microvascular dermal endothelial cells.
PLoS pathogens10(2)e1003941(2014 Feb)
Bandyopadhyay C,Valiya-Veettil M,Dutta D,Chakraborty S,Chandran B

The prognostic role of ephrin A2 and endothelial growth factor receptor pathway mediators in patients with advanced colorectal cancer treated with cetuximab.
Clinical colorectal cancer12(4)267-274.e2(2013 Dec)
Strimpakos A,Pentheroudakis G,Kotoula V,De Roock W,Kouvatseas G,Papakostas P,Makatsoris T,Papamichael D,Andreadou A,Sgouros J,Zizi-Sermpetzoglou A,Kominea A,Televantou D,Razis E,Galani E,Pectasides D,Tejpar S,Syrigos K,Fountzilas G

EphA2 activation promotes the endothelial cell inflammatory response: a potential role in atherosclerosis.
Arteriosclerosis, thrombosis, and vascular biology32(3)686-95(2012 Mar)
Funk SD,Yurdagul A Jr,Albert P,Traylor JG Jr,Jin L,Chen J,Orr AW

The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction.
Circulation research108(9)1071-83(2011 Apr)
Goichberg P,Bai Y,D'Amario D,Ferreira-Martins J,Fiorini C,Zheng H,Signore S,del Monte F,Ottolenghi S,D'Alessandro DA,Michler RE,Hosoda T,Anversa P,Kajstura J,Rota M,Leri A

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EFNA2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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