DSG3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DSG3
Entrez Gene ID	1830
Full Name	desmoglein 3
Synonyms	CDHF6,PVA
General protein information	Preferred Names desmoglein 3 Names desmoglein-3 130 kDa pemphigus vulgaris antigen cadherin family member 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q12.1
Summary	This gene encodes a member of the desmoglein family and cadherin cell adhesion molecule superfamily of proteins. Desmogleins are calcium-binding transmembrane glycoprotein components of desmosomes, cell-cell junctions between epithelial, myocardial, and other cell types. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This gene is present in a gene cluster with other desmoglein gene family members on chromosome 18. The encoded protein has been identified as the autoantigen of the autoimmune blistering disease pemphigus vulgaris. [provided by RefSeq, Jan 2016].
Disorder MIM:	169615

mRNA and Protein(s)

mRNA	Protein	Name
XM_011525850.1	XP_011524152.1	desmoglein-3 isoform X1
NM_001944.2	NP_001935.2	desmoglein-3 preproprotein
XM_011525850.2	XP_011524152.1	desmoglein-3 isoform X1
NM_001944.3	NP_001935.2	desmoglein-3 preproprotein

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Dsg3	NP_085099.2
Rattus norvegicus (Norway rat)	Dsg3	NP_001178008.1
	DSG3	XP_001098409.2
Bos taurus (cattle)	DSG3	NP_001179614.1
Homo sapiens (human)	DSG3	NP_001935.2
Pan troglodytes (chimpanzee)	DSG3	XP_523900.3
Canis lupus familiaris (dog)	DSG3	NP_001002983.1

Gene Ontology
Bibliography

Related articles in PubMed

Desmoglein 3 Order and Dynamics in Desmosomes Determined by Fluorescence Polarization Microscopy.
Bartle EI, Urner TM, Raju SS, Mattheyses AL
Biophysical journal113(11)2519-2529(2017 Dec)

Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus.
Walter E, Vielmuth F, Rotkopf L, S?rdy M, Horv?th ON, Goebeler M, Schmidt E, Eming R, Hertl M, Spindler V, Waschke J
Scientific reports7(1)3579(2017 Jun)

Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes.
V?llner F, Ali J, Kurrle N, Exner Y, Eming R, Hertl M, Banning A, Tikkanen R
Scientific reports628820(2016 Jun)

Pathogenicity and Epitope Characteristics Do Not Differ in IgG Subclass-Switched Anti-Desmoglein 3 IgG1 and IgG4 Autoantibodies in Pemphigus Vulgaris.
Lo AS, Mao X, Mukherjee EM, Ellebrecht CT, Yu X, Posner MR, Payne AS, Cavacini LA
PloS one11(6)e0156800(2016)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Desmoglein 3 Order and Dynamics in Desmosomes
Title: Desmoglein 3 Order and Dynamics in Desmosomes Determined by Fluorescence Polarization Microscopy.

DSG3 was a key prognostic factor and predictor for neoadjuvant concurrent chemoradiotherapy response in rectal cancer patients.
Title: Prognostic significance of DSG3 in rectal adenocarcinoma treated with preoperative chemoradiotherapy.

Treg cells exert a clear down-regulatory effect on the Dsg3-driven T-cell response and, accordingly, the formation of Dsg3-specific IgG antibodies
Title: Induction of T regulatory cells by the superagonistic anti-CD28 antibody D665 leads to decreased pathogenic IgG autoantibodies against desmoglein 3 in a HLA-transgenic mouse model of pemphigus vulgaris.

Data indicate that all 3 monoclonal antibodies (mAbs) targeted the same extracellular cadherin (EC) domain on desmoglein 3 (Dsg3), caused Dsg3 internalization in primary keratinocytes, and caused suprabasal blisters in skin.
Title: Pathogenicity and Epitope Characteristics Do Not Differ in IgG Subclass-Switched Anti-Desmoglein 3 IgG1 and IgG4 Autoantibodies in Pemphigus Vulgaris.

Data identify DSG3 as a negative prognostic biomarker in resected pancreatic ductal adenocarcinoma, as high DSG3 expression is associated with poor overall survival and poor tumour-specific survival.
Title: Desmogleins as prognostic biomarkers in resected pancreatic ductal adenocarcinoma.

The following DSG3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DSG3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29103	NM_001944.3 Latest version!	Homo sapiens desmoglein 3 (DSG3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$657.30 $939.00
OHu57381	XM_011525850.2 Latest version!	Homo sapiens desmoglein 3 (DSG3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
View Old Accession Versions >>
OHu57381	XM_011525850.1	Homo sapiens desmoglein 3 (DSG3), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu29103	NM_001944.2	Homo sapiens desmoglein 3 (DSG3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$657.30 $939.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DSG3 ( NM_001944.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001935.2 Homo sapiens desmoglein 3 (DSG3), mRNA.

Price & Availability↑

CloneID	OHu29103
Clone ID Related Accession (Same CDS sequence)	NM_001944.2 , NM_001944.3
Accession Version	NM_001944.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3000bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	desmoglein-3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA458544.1, M76482.1, AC021549.9, DA447747.1, AI608626.1, U51696.1, BX507120.1, BX110234.1 and BC105997.1. On Dec 27, 2006 this sequence version replaced NM_001944.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290367.1, M76482.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: full length.

ATGATGGGGC TCTTCCCCAG AACTACAGGG GCTCTGGCCA TCTTCGTGGT GGTCATATTG 
GTTCATGGAG AATTGCGAAT AGAGACTAAA GGTCAATATG ATGAAGAAGA GATGACTATG 
CAACAAGCTA AAAGAAGGCA AAAACGTGAA TGGGTGAAAT TTGCCAAACC CTGCAGAGAA 
GGAGAAGATA ACTCAAAAAG AAACCCAATT GCCAAGATTA CTTCAGATTA CCAAGCAACC 
CAGAAAATCA CCTACCGAAT CTCTGGAGTG GGAATCGATC AGCCGCCTTT TGGAATCTTT 
GTTGTTGACA AAAACACTGG AGATATTAAC ATAACAGCTA TAGTCGACCG GGAGGAAACT 
CCAAGCTTCC TGATCACATG TCGGGCTCTA AATGCCCAAG GACTAGATGT AGAGAAACCA 
CTTATACTAA CGGTTAAAAT TTTGGATATT AATGATAATC CTCCAGTATT TTCACAACAA 
ATTTTCATGG GTGAAATTGA AGAAAATAGT GCCTCAAACT CACTGGTGAT GATACTAAAT 
GCCACAGATG CAGATGAACC AAACCACTTG AATTCTAAAA TTGCCTTCAA AATTGTCTCT 
CAGGAACCAG CAGGCACACC CATGTTCCTC CTAAGCAGAA ACACTGGGGA AGTCCGTACT 
TTGACCAATT CTCTTGACCG AGAGCAAGCT AGCAGCTATC GTCTGGTTGT GAGTGGTGCA 
GACAAAGATG GAGAAGGACT ATCAACTCAA TGTGAATGTA ATATTAAAGT GAAAGATGTC 
AACGATAACT TCCCAATGTT TAGAGACTCT CAGTATTCAG CACGTATTGA AGAAAATATT 
TTAAGTTCTG AATTACTTCG ATTTCAAGTA ACAGATTTGG ATGAAGAGTA CACAGATAAT 
TGGCTTGCAG TATATTTCTT TACCTCTGGG AATGAAGGAA ATTGGTTTGA AATACAAACT 
GATCCTAGAA CTAATGAAGG CATCCTGAAA GTGGTGAAGG CTCTAGATTA TGAACAACTA 
CAAAGCGTGA AACTTAGTAT TGCTGTCAAA AACAAAGCTG AATTTCACCA ATCAGTTATC 
TCTCGATACC GAGTTCAGTC AACCCCAGTC ACAATTCAGG TAATAAATGT AAGAGAAGGA 
ATTGCATTCC GTCCTGCTTC CAAGACATTT ACTGTGCAAA AAGGCATAAG TAGCAAAAAA 
TTGGTGGATT ATATCCTGGG AACATATCAA GCCATCGATG AGGACACTAA CAAAGCTGCC 
TCAAATGTCA AATATGTCAT GGGACGTAAC GATGGTGGAT ACCTAATGAT TGATTCAAAA 
ACTGCTGAAA TCAAATTTGT CAAAAATATG AACCGAGATT CTACTTTCAT AGTTAACAAA 
ACAATCACAG CTGAGGTTCT GGCCATAGAT GAATACACGG GTAAAACTTC TACAGGCACG 
GTATATGTTA GAGTACCCGA TTTCAATGAC AATTGTCCAA CAGCTGTCCT CGAAAAAGAT 
GCAGTTTGCA GTTCTTCACC TTCCGTGGTT GTCTCCGCTA GAACACTGAA TAATAGATAC 
ACTGGCCCCT ATACATTTGC ACTGGAAGAT CAACCTGTAA AGTTGCCTGC CGTATGGAGT 
ATCACAACCC TCAATGCTAC CTCGGCCCTC CTCAGAGCCC AGGAACAGAT ACCTCCTGGA 
GTATACCACA TCTCCCTGGT ACTTACAGAC AGTCAGAACA ATCGGTGTGA GATGCCACGC 
AGCTTGACAC TGGAAGTCTG TCAGTGTGAC AACAGGGGCA TCTGTGGAAC TTCTTACCCA 
ACCACAAGCC CTGGGACCAG GTATGGCAGG CCGCACTCAG GGAGGCTGGG GCCTGCCGCC 
ATCGGCCTGC TGCTCCTTGG TCTCCTGCTG CTGCTGTTGG CCCCCCTTCT GCTGTTGACC 
TGTGACTGTG GGGCAGGTTC TACTGGGGGA GTGACAGGTG GTTTTATCCC AGTTCCTGAT 
GGCTCAGAAG GAACAATTCA TCAGTGGGGA ATTGAAGGAG CCCATCCTGA AGACAAGGAA 
ATCACAAATA TTTGTGTGCC TCCTGTAACA GCCAATGGAG CCGATTTCAT GGAAAGTTCT 
GAAGTTTGTA CAAATACGTA TGCCAGAGGC ACAGCGGTGG AAGGCACTTC AGGAATGGAA 
ATGACCACTA AGCTTGGAGC AGCCACTGAA TCTGGAGGTG CTGCAGGCTT TGCAACAGGG 
ACAGTGTCAG GAGCTGCTTC AGGATTCGGA GCAGCCACTG GAGTTGGCAT CTGTTCCTCA 
GGGCAGTCTG GAACCATGAG AACAAGGCAT TCCACTGGAG GAACCAATAA GGACTACGCT 
GATGGGGCGA TAAGCATGAA TTTTCTGGAC TCCTACTTTT CTCAGAAAGC ATTTGCCTGT 
GCGGAGGAAG ACGATGGCCA GGAAGCAAAT GACTGCTTGT TGATCTATGA TAATGAAGGC 
GCAGATGCCA CTGGTTCTCC TGTGGGCTCC GTGGGTTGTT GCAGTTTTAT TGCTGATGAC 
CTGGATGACA GCTTCTTGGA CTCACTTGGA CCCAAATTTA AAAAACTTGC AGAGATAAGC 
CTTGGTGTTG ATGGTGAAGG CAAAGAAGTT CAGCCACCCT CTAAAGACAG CGGTTATGGG 
ATTGAATCCT GTGGCCATCC CATAGAAGTC CAGCAGACAG GATTTGTTAA GTGCCAGACT 
TTGTCAGGAA GTCAAGGAGC TTCTGCTTTG TCCACCTCTG GGTCTGTCCA GCCAGCTGTT 
TCCATCCCTG ACCCTCTGCA GCATGGTAAC TATTTAGTAA CGGAGACTTA CTCGGCTTCT 
GGTTCCCTCG TGCAACCTTC CACTGCAGGC TTTGATCCAC TTCTCACACA AAATGTGATA 
GTGACAGAAA GGGTGATCTG TCCCATTTCC AGTGTTCCTG GCAACCTAGC TGGCCCAACG 
CAGCTACGAG GGTCACATAC TATGCTCTGT ACAGAGGATC CTTGCTCCCG TCTAATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001935.2
CDS	110..3109
Translation	MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQTLSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTMLCTEDPCSRLI

Target ORF information:

RefSeq Version	NM_001944.2
Organism	Homo sapiens(human)
Definition	Homo sapiens desmoglein 3 (DSG3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001944.2

ORF Insert Sequence:

ATGATGGGGC TCTTCCCCAG AACTACAGGG GCTCTGGCCA TCTTCGTGGT GGTCATATTG 
GTTCATGGAG AATTGCGAAT AGAGACTAAA GGTCAATATG ATGAAGAAGA GATGACTATG 
CAACAAGCTA AAAGAAGGCA AAAACGTGAA TGGGTGAAAT TTGCCAAACC CTGCAGAGAA 
GGAGAAGATA ACTCAAAAAG AAACCCAATT GCCAAGATTA CTTCAGATTA CCAAGCAACC 
CAGAAAATCA CCTACCGAAT CTCTGGAGTG GGAATCGATC AGCCGCCTTT TGGAATCTTT 
GTTGTTGACA AAAACACTGG AGATATTAAC ATAACAGCTA TAGTCGACCG GGAGGAAACT 
CCAAGCTTCC TGATCACATG TCGGGCTCTA AATGCCCAAG GACTAGATGT AGAGAAACCA 
CTTATACTAA CGGTTAAAAT TTTGGATATT AATGATAATC CTCCAGTATT TTCACAACAA 
ATTTTCATGG GTGAAATTGA AGAAAATAGT GCCTCAAACT CACTGGTGAT GATACTAAAT 
GCCACAGATG CAGATGAACC AAACCACTTG AATTCTAAAA TTGCCTTCAA AATTGTCTCT 
CAGGAACCAG CAGGCACACC CATGTTCCTC CTAAGCAGAA ACACTGGGGA AGTCCGTACT 
TTGACCAATT CTCTTGACCG AGAGCAAGCT AGCAGCTATC GTCTGGTTGT GAGTGGTGCA 
GACAAAGATG GAGAAGGACT ATCAACTCAA TGTGAATGTA ATATTAAAGT GAAAGATGTC 
AACGATAACT TCCCAATGTT TAGAGACTCT CAGTATTCAG CACGTATTGA AGAAAATATT 
TTAAGTTCTG AATTACTTCG ATTTCAAGTA ACAGATTTGG ATGAAGAGTA CACAGATAAT 
TGGCTTGCAG TATATTTCTT TACCTCTGGG AATGAAGGAA ATTGGTTTGA AATACAAACT 
GATCCTAGAA CTAATGAAGG CATCCTGAAA GTGGTGAAGG CTCTAGATTA TGAACAACTA 
CAAAGCGTGA AACTTAGTAT TGCTGTCAAA AACAAAGCTG AATTTCACCA ATCAGTTATC 
TCTCGATACC GAGTTCAGTC AACCCCAGTC ACAATTCAGG TAATAAATGT AAGAGAAGGA 
ATTGCATTCC GTCCTGCTTC CAAGACATTT ACTGTGCAAA AAGGCATAAG TAGCAAAAAA 
TTGGTGGATT ATATCCTGGG AACATATCAA GCCATCGATG AGGACACTAA CAAAGCTGCC 
TCAAATGTCA AATATGTCAT GGGACGTAAC GATGGTGGAT ACCTAATGAT TGATTCAAAA 
ACTGCTGAAA TCAAATTTGT CAAAAATATG AACCGAGATT CTACTTTCAT AGTTAACAAA 
ACAATCACAG CTGAGGTTCT GGCCATAGAT GAATACACGG GTAAAACTTC TACAGGCACG 
GTATATGTTA GAGTACCCGA TTTCAATGAC AATTGTCCAA CAGCTGTCCT CGAAAAAGAT 
GCAGTTTGCA GTTCTTCACC TTCCGTGGTT GTCTCCGCTA GAACACTGAA TAATAGATAC 
ACTGGCCCCT ATACATTTGC ACTGGAAGAT CAACCTGTAA AGTTGCCTGC CGTATGGAGT 
ATCACAACCC TCAATGCTAC CTCGGCCCTC CTCAGAGCCC AGGAACAGAT ACCTCCTGGA 
GTATACCACA TCTCCCTGGT ACTTACAGAC AGTCAGAACA ATCGGTGTGA GATGCCACGC 
AGCTTGACAC TGGAAGTCTG TCAGTGTGAC AACAGGGGCA TCTGTGGAAC TTCTTACCCA 
ACCACAAGCC CTGGGACCAG GTATGGCAGG CCGCACTCAG GGAGGCTGGG GCCTGCCGCC 
ATCGGCCTGC TGCTCCTTGG TCTCCTGCTG CTGCTGTTGG CCCCCCTTCT GCTGTTGACC 
TGTGACTGTG GGGCAGGTTC TACTGGGGGA GTGACAGGTG GTTTTATCCC AGTTCCTGAT 
GGCTCAGAAG GAACAATTCA TCAGTGGGGA ATTGAAGGAG CCCATCCTGA AGACAAGGAA 
ATCACAAATA TTTGTGTGCC TCCTGTAACA GCCAATGGAG CCGATTTCAT GGAAAGTTCT 
GAAGTTTGTA CAAATACGTA TGCCAGAGGC ACAGCGGTGG AAGGCACTTC AGGAATGGAA 
ATGACCACTA AGCTTGGAGC AGCCACTGAA TCTGGAGGTG CTGCAGGCTT TGCAACAGGG 
ACAGTGTCAG GAGCTGCTTC AGGATTCGGA GCAGCCACTG GAGTTGGCAT CTGTTCCTCA 
GGGCAGTCTG GAACCATGAG AACAAGGCAT TCCACTGGAG GAACCAATAA GGACTACGCT 
GATGGGGCGA TAAGCATGAA TTTTCTGGAC TCCTACTTTT CTCAGAAAGC ATTTGCCTGT 
GCGGAGGAAG ACGATGGCCA GGAAGCAAAT GACTGCTTGT TGATCTATGA TAATGAAGGC 
GCAGATGCCA CTGGTTCTCC TGTGGGCTCC GTGGGTTGTT GCAGTTTTAT TGCTGATGAC 
CTGGATGACA GCTTCTTGGA CTCACTTGGA CCCAAATTTA AAAAACTTGC AGAGATAAGC 
CTTGGTGTTG ATGGTGAAGG CAAAGAAGTT CAGCCACCCT CTAAAGACAG CGGTTATGGG 
ATTGAATCCT GTGGCCATCC CATAGAAGTC CAGCAGACAG GATTTGTTAA GTGCCAGACT 
TTGTCAGGAA GTCAAGGAGC TTCTGCTTTG TCCACCTCTG GGTCTGTCCA GCCAGCTGTT 
TCCATCCCTG ACCCTCTGCA GCATGGTAAC TATTTAGTAA CGGAGACTTA CTCGGCTTCT 
GGTTCCCTCG TGCAACCTTC CACTGCAGGC TTTGATCCAC TTCTCACACA AAATGTGATA 
GTGACAGAAA GGGTGATCTG TCCCATTTCC AGTGTTCCTG GCAACCTAGC TGGCCCAACG 
CAGCTACGAG GGTCACATAC TATGCTCTGT ACAGAGGATC CTTGCTCCCG TCTAATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSG3 ( NM_001944.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001935.2 Homo sapiens desmoglein 3 (DSG3), mRNA.

Price & Availability↑

CloneID	OHu29103
Clone ID Related Accession (Same CDS sequence)	NM_001944.2 , NM_001944.3
Accession Version	NM_001944.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 3000bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-07-30
Organism	Homo sapiens(human)
Product	desmoglein-3 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC021549.9, DA458544.1, M76482.1, DA447747.1, AI608626.1, U51696.1, BX507120.1, BX110234.1 and BC105997.1. On Nov 22, 2018 this sequence version replaced NM_001944.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK290367.1, M76482.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144335, SAMEA2144835 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000257189.5/ ENSP00000257189.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGGGGC TCTTCCCCAG AACTACAGGG GCTCTGGCCA TCTTCGTGGT GGTCATATTG 
GTTCATGGAG AATTGCGAAT AGAGACTAAA GGTCAATATG ATGAAGAAGA GATGACTATG 
CAACAAGCTA AAAGAAGGCA AAAACGTGAA TGGGTGAAAT TTGCCAAACC CTGCAGAGAA 
GGAGAAGATA ACTCAAAAAG AAACCCAATT GCCAAGATTA CTTCAGATTA CCAAGCAACC 
CAGAAAATCA CCTACCGAAT CTCTGGAGTG GGAATCGATC AGCCGCCTTT TGGAATCTTT 
GTTGTTGACA AAAACACTGG AGATATTAAC ATAACAGCTA TAGTCGACCG GGAGGAAACT 
CCAAGCTTCC TGATCACATG TCGGGCTCTA AATGCCCAAG GACTAGATGT AGAGAAACCA 
CTTATACTAA CGGTTAAAAT TTTGGATATT AATGATAATC CTCCAGTATT TTCACAACAA 
ATTTTCATGG GTGAAATTGA AGAAAATAGT GCCTCAAACT CACTGGTGAT GATACTAAAT 
GCCACAGATG CAGATGAACC AAACCACTTG AATTCTAAAA TTGCCTTCAA AATTGTCTCT 
CAGGAACCAG CAGGCACACC CATGTTCCTC CTAAGCAGAA ACACTGGGGA AGTCCGTACT 
TTGACCAATT CTCTTGACCG AGAGCAAGCT AGCAGCTATC GTCTGGTTGT GAGTGGTGCA 
GACAAAGATG GAGAAGGACT ATCAACTCAA TGTGAATGTA ATATTAAAGT GAAAGATGTC 
AACGATAACT TCCCAATGTT TAGAGACTCT CAGTATTCAG CACGTATTGA AGAAAATATT 
TTAAGTTCTG AATTACTTCG ATTTCAAGTA ACAGATTTGG ATGAAGAGTA CACAGATAAT 
TGGCTTGCAG TATATTTCTT TACCTCTGGG AATGAAGGAA ATTGGTTTGA AATACAAACT 
GATCCTAGAA CTAATGAAGG CATCCTGAAA GTGGTGAAGG CTCTAGATTA TGAACAACTA 
CAAAGCGTGA AACTTAGTAT TGCTGTCAAA AACAAAGCTG AATTTCACCA ATCAGTTATC 
TCTCGATACC GAGTTCAGTC AACCCCAGTC ACAATTCAGG TAATAAATGT AAGAGAAGGA 
ATTGCATTCC GTCCTGCTTC CAAGACATTT ACTGTGCAAA AAGGCATAAG TAGCAAAAAA 
TTGGTGGATT ATATCCTGGG AACATATCAA GCCATCGATG AGGACACTAA CAAAGCTGCC 
TCAAATGTCA AATATGTCAT GGGACGTAAC GATGGTGGAT ACCTAATGAT TGATTCAAAA 
ACTGCTGAAA TCAAATTTGT CAAAAATATG AACCGAGATT CTACTTTCAT AGTTAACAAA 
ACAATCACAG CTGAGGTTCT GGCCATAGAT GAATACACGG GTAAAACTTC TACAGGCACG 
GTATATGTTA GAGTACCCGA TTTCAATGAC AATTGTCCAA CAGCTGTCCT CGAAAAAGAT 
GCAGTTTGCA GTTCTTCACC TTCCGTGGTT GTCTCCGCTA GAACACTGAA TAATAGATAC 
ACTGGCCCCT ATACATTTGC ACTGGAAGAT CAACCTGTAA AGTTGCCTGC CGTATGGAGT 
ATCACAACCC TCAATGCTAC CTCGGCCCTC CTCAGAGCCC AGGAACAGAT ACCTCCTGGA 
GTATACCACA TCTCCCTGGT ACTTACAGAC AGTCAGAACA ATCGGTGTGA GATGCCACGC 
AGCTTGACAC TGGAAGTCTG TCAGTGTGAC AACAGGGGCA TCTGTGGAAC TTCTTACCCA 
ACCACAAGCC CTGGGACCAG GTATGGCAGG CCGCACTCAG GGAGGCTGGG GCCTGCCGCC 
ATCGGCCTGC TGCTCCTTGG TCTCCTGCTG CTGCTGTTGG CCCCCCTTCT GCTGTTGACC 
TGTGACTGTG GGGCAGGTTC TACTGGGGGA GTGACAGGTG GTTTTATCCC AGTTCCTGAT 
GGCTCAGAAG GAACAATTCA TCAGTGGGGA ATTGAAGGAG CCCATCCTGA AGACAAGGAA 
ATCACAAATA TTTGTGTGCC TCCTGTAACA GCCAATGGAG CCGATTTCAT GGAAAGTTCT 
GAAGTTTGTA CAAATACGTA TGCCAGAGGC ACAGCGGTGG AAGGCACTTC AGGAATGGAA 
ATGACCACTA AGCTTGGAGC AGCCACTGAA TCTGGAGGTG CTGCAGGCTT TGCAACAGGG 
ACAGTGTCAG GAGCTGCTTC AGGATTCGGA GCAGCCACTG GAGTTGGCAT CTGTTCCTCA 
GGGCAGTCTG GAACCATGAG AACAAGGCAT TCCACTGGAG GAACCAATAA GGACTACGCT 
GATGGGGCGA TAAGCATGAA TTTTCTGGAC TCCTACTTTT CTCAGAAAGC ATTTGCCTGT 
GCGGAGGAAG ACGATGGCCA GGAAGCAAAT GACTGCTTGT TGATCTATGA TAATGAAGGC 
GCAGATGCCA CTGGTTCTCC TGTGGGCTCC GTGGGTTGTT GCAGTTTTAT TGCTGATGAC 
CTGGATGACA GCTTCTTGGA CTCACTTGGA CCCAAATTTA AAAAACTTGC AGAGATAAGC 
CTTGGTGTTG ATGGTGAAGG CAAAGAAGTT CAGCCACCCT CTAAAGACAG CGGTTATGGG 
ATTGAATCCT GTGGCCATCC CATAGAAGTC CAGCAGACAG GATTTGTTAA GTGCCAGACT 
TTGTCAGGAA GTCAAGGAGC TTCTGCTTTG TCCACCTCTG GGTCTGTCCA GCCAGCTGTT 
TCCATCCCTG ACCCTCTGCA GCATGGTAAC TATTTAGTAA CGGAGACTTA CTCGGCTTCT 
GGTTCCCTCG TGCAACCTTC CACTGCAGGC TTTGATCCAC TTCTCACACA AAATGTGATA 
GTGACAGAAA GGGTGATCTG TCCCATTTCC AGTGTTCCTG GCAACCTAGC TGGCCCAACG 
CAGCTACGAG GGTCACATAC TATGCTCTGT ACAGAGGATC CTTGCTCCCG TCTAATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001935.2
CDS	138..3137
Translation	MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQTLSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTMLCTEDPCSRLI

Target ORF information:

RefSeq Version	NM_001944.3
Organism	Homo sapiens(human)
Definition	Homo sapiens desmoglein 3 (DSG3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001944.3

ORF Insert Sequence:

ATGATGGGGC TCTTCCCCAG AACTACAGGG GCTCTGGCCA TCTTCGTGGT GGTCATATTG 
GTTCATGGAG AATTGCGAAT AGAGACTAAA GGTCAATATG ATGAAGAAGA GATGACTATG 
CAACAAGCTA AAAGAAGGCA AAAACGTGAA TGGGTGAAAT TTGCCAAACC CTGCAGAGAA 
GGAGAAGATA ACTCAAAAAG AAACCCAATT GCCAAGATTA CTTCAGATTA CCAAGCAACC 
CAGAAAATCA CCTACCGAAT CTCTGGAGTG GGAATCGATC AGCCGCCTTT TGGAATCTTT 
GTTGTTGACA AAAACACTGG AGATATTAAC ATAACAGCTA TAGTCGACCG GGAGGAAACT 
CCAAGCTTCC TGATCACATG TCGGGCTCTA AATGCCCAAG GACTAGATGT AGAGAAACCA 
CTTATACTAA CGGTTAAAAT TTTGGATATT AATGATAATC CTCCAGTATT TTCACAACAA 
ATTTTCATGG GTGAAATTGA AGAAAATAGT GCCTCAAACT CACTGGTGAT GATACTAAAT 
GCCACAGATG CAGATGAACC AAACCACTTG AATTCTAAAA TTGCCTTCAA AATTGTCTCT 
CAGGAACCAG CAGGCACACC CATGTTCCTC CTAAGCAGAA ACACTGGGGA AGTCCGTACT 
TTGACCAATT CTCTTGACCG AGAGCAAGCT AGCAGCTATC GTCTGGTTGT GAGTGGTGCA 
GACAAAGATG GAGAAGGACT ATCAACTCAA TGTGAATGTA ATATTAAAGT GAAAGATGTC 
AACGATAACT TCCCAATGTT TAGAGACTCT CAGTATTCAG CACGTATTGA AGAAAATATT 
TTAAGTTCTG AATTACTTCG ATTTCAAGTA ACAGATTTGG ATGAAGAGTA CACAGATAAT 
TGGCTTGCAG TATATTTCTT TACCTCTGGG AATGAAGGAA ATTGGTTTGA AATACAAACT 
GATCCTAGAA CTAATGAAGG CATCCTGAAA GTGGTGAAGG CTCTAGATTA TGAACAACTA 
CAAAGCGTGA AACTTAGTAT TGCTGTCAAA AACAAAGCTG AATTTCACCA ATCAGTTATC 
TCTCGATACC GAGTTCAGTC AACCCCAGTC ACAATTCAGG TAATAAATGT AAGAGAAGGA 
ATTGCATTCC GTCCTGCTTC CAAGACATTT ACTGTGCAAA AAGGCATAAG TAGCAAAAAA 
TTGGTGGATT ATATCCTGGG AACATATCAA GCCATCGATG AGGACACTAA CAAAGCTGCC 
TCAAATGTCA AATATGTCAT GGGACGTAAC GATGGTGGAT ACCTAATGAT TGATTCAAAA 
ACTGCTGAAA TCAAATTTGT CAAAAATATG AACCGAGATT CTACTTTCAT AGTTAACAAA 
ACAATCACAG CTGAGGTTCT GGCCATAGAT GAATACACGG GTAAAACTTC TACAGGCACG 
GTATATGTTA GAGTACCCGA TTTCAATGAC AATTGTCCAA CAGCTGTCCT CGAAAAAGAT 
GCAGTTTGCA GTTCTTCACC TTCCGTGGTT GTCTCCGCTA GAACACTGAA TAATAGATAC 
ACTGGCCCCT ATACATTTGC ACTGGAAGAT CAACCTGTAA AGTTGCCTGC CGTATGGAGT 
ATCACAACCC TCAATGCTAC CTCGGCCCTC CTCAGAGCCC AGGAACAGAT ACCTCCTGGA 
GTATACCACA TCTCCCTGGT ACTTACAGAC AGTCAGAACA ATCGGTGTGA GATGCCACGC 
AGCTTGACAC TGGAAGTCTG TCAGTGTGAC AACAGGGGCA TCTGTGGAAC TTCTTACCCA 
ACCACAAGCC CTGGGACCAG GTATGGCAGG CCGCACTCAG GGAGGCTGGG GCCTGCCGCC 
ATCGGCCTGC TGCTCCTTGG TCTCCTGCTG CTGCTGTTGG CCCCCCTTCT GCTGTTGACC 
TGTGACTGTG GGGCAGGTTC TACTGGGGGA GTGACAGGTG GTTTTATCCC AGTTCCTGAT 
GGCTCAGAAG GAACAATTCA TCAGTGGGGA ATTGAAGGAG CCCATCCTGA AGACAAGGAA 
ATCACAAATA TTTGTGTGCC TCCTGTAACA GCCAATGGAG CCGATTTCAT GGAAAGTTCT 
GAAGTTTGTA CAAATACGTA TGCCAGAGGC ACAGCGGTGG AAGGCACTTC AGGAATGGAA 
ATGACCACTA AGCTTGGAGC AGCCACTGAA TCTGGAGGTG CTGCAGGCTT TGCAACAGGG 
ACAGTGTCAG GAGCTGCTTC AGGATTCGGA GCAGCCACTG GAGTTGGCAT CTGTTCCTCA 
GGGCAGTCTG GAACCATGAG AACAAGGCAT TCCACTGGAG GAACCAATAA GGACTACGCT 
GATGGGGCGA TAAGCATGAA TTTTCTGGAC TCCTACTTTT CTCAGAAAGC ATTTGCCTGT 
GCGGAGGAAG ACGATGGCCA GGAAGCAAAT GACTGCTTGT TGATCTATGA TAATGAAGGC 
GCAGATGCCA CTGGTTCTCC TGTGGGCTCC GTGGGTTGTT GCAGTTTTAT TGCTGATGAC 
CTGGATGACA GCTTCTTGGA CTCACTTGGA CCCAAATTTA AAAAACTTGC AGAGATAAGC 
CTTGGTGTTG ATGGTGAAGG CAAAGAAGTT CAGCCACCCT CTAAAGACAG CGGTTATGGG 
ATTGAATCCT GTGGCCATCC CATAGAAGTC CAGCAGACAG GATTTGTTAA GTGCCAGACT 
TTGTCAGGAA GTCAAGGAGC TTCTGCTTTG TCCACCTCTG GGTCTGTCCA GCCAGCTGTT 
TCCATCCCTG ACCCTCTGCA GCATGGTAAC TATTTAGTAA CGGAGACTTA CTCGGCTTCT 
GGTTCCCTCG TGCAACCTTC CACTGCAGGC TTTGATCCAC TTCTCACACA AAATGTGATA 
GTGACAGAAA GGGTGATCTG TCCCATTTCC AGTGTTCCTG GCAACCTAGC TGGCCCAACG 
CAGCTACGAG GGTCACATAC TATGCTCTGT ACAGAGGATC CTTGCTCCCG TCTAATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSG3 ( XM_011525850.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524152.1 Homo sapiens desmoglein 3 (DSG3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu57381
Clone ID Related Accession (Same CDS sequence)	XM_011525850.1 , XM_011525850.2
Accession Version	XM_011525850.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2997bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	desmoglein-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGGGGC TCTTCCCCAG AACTACAGGG GCTCTGGCCA TCTTCGTGGT GGTCATATTG 
GTTCATGGAG AATTGCGAAT AGAGACTAAA GGTCAATATG ATGAAGAAGA GATGACTATG 
CAACAAGCTA AAAGAAGGCA AAAACGTGAA TGGGTGAAAT TTGCCAAACC CTGCAGAGAA 
GGAGAAGATA ACTCAAAAAG AAACCCAATT GCCAAGATTA CTTCAGATTA CCAAGCAACC 
CAGAAAATCA CCTACCGAAT CTCTGGAGTG GGAATCGATC AGCCGCCTTT TGGAATCTTT 
GTTGTTGACA AAAACACTGG AGATATTAAC ATAACAGCTA TAGTCGACCG GGAGGAAACT 
CCAAGCTTCC TGATCACATG TCGGGCTCTA AATGCCCAAG GACTAGATGT AGAGAAACCA 
CTTATACTAA CGGTTAAAAT TTTGGATATT AATGATAATC CTCCAGTATT TTCACAACAA 
ATTTTCATGG GTGAAATTGA AGAAAATAGT GCCTCAAACT CACTGGTGAT GATACTAAAT 
GCCACAGATG CAGATGAACC AAACCACTTG AATTCTAAAA TTGCCTTCAA AATTGTCTCT 
CAGGAACCAG CAGGCACACC CATGTTCCTC CTAAGCAGAA ACACTGGGGA AGTCCGTACT 
TTGACCAATT CTCTTGACCG AGAGCAAGCT AGCAGCTATC GTCTGGTTGT GAGTGGTGCA 
GACAAAGATG GAGAAGGACT ATCAACTCAA TGTGAATGTA ATATTAAAGT GAAAGATGTC 
AACGATAACT TCCCAATGTT TAGAGACTCT CAGTATTCAG CACGTATTGA AGAAAATATT 
TTAAGTTCTG AATTACTTCG ATTTCAAGTA ACAGATTTGG ATGAAGAGTA CACAGATAAT 
TGGCTTGCAG TATATTTCTT TACCTCTGGG AATGAAGGAA ATTGGTTTGA AATACAAACT 
GATCCTAGAA CTAATGAAGG CATCCTGAAA GTGGTGAAGG CTCTAGATTA TGAACAACTA 
CAAAGCGTGA AACTTAGTAT TGCTGTCAAA AACAAAGCTG AATTTCACCA ATCAGTTATC 
TCTCGATACC GAGTTCAGTC AACCCCAGTC ACAATTCAGG TAATAAATGT AAGAGAAGGA 
ATTGCATTCC GTCCTGCTTC CAAGACATTT ACTGTGCAAA AAGGCATAAG TAGCAAAAAA 
TTGGTGGATT ATATCCTGGG AACATATCAA GCCATCGATG AGGACACTAA CAAAGCTGCC 
TCAAATGTCA AATATGTCAT GGGACGTAAC GATGGTGGAT ACCTAATGAT TGATTCAAAA 
ACTGCTGAAA TCAAATTTGT CAAAAATATG AACCGAGATT CTACTTTCAT AGTTAACAAA 
ACAATCACAG CTGAGGTTCT GGCCATAGAT GAATACACGG GTAAAACTTC TACAGGCACG 
GTATATGTTA GAGTACCCGA TTTCAATGAC AATTGTCCAA CAGCTGTCCT CGAAAAAGAT 
GCAGTTTGCA GTTCTTCACC TTCCGTGGTT GTCTCCGCTA GAACACTGAA TAATAGATAC 
ACTGGCCCCT ATACATTTGC ACTGGAAGAT CAACCTGTAA AGTTGCCTGC CGTATGGAGT 
ATCACAACCC TCAATGCTAC CTCGGCCCTC CTCAGAGCCC AGGAACAGAT ACCTCCTGGA 
GTATACCACA TCTCCCTGGT ACTTACAGAC AGTCAGAACA ATCGGTGTGA GATGCCACGC 
AGCTTGACAC TGGAAGTCTG TCAGTGTGAC AACAGGGGCA TCTGTGGAAC TTCTTACCCA 
ACCACAAGCC CTGGGACCAG GTATGGCAGG CCGCACTCAG GGAGGCTGGG GCCTGCCGCC 
ATCGGCCTGC TGCTCCTTGG TCTCCTGCTG CTGCTGTTGG CCCCCCTTCT GCTGTTGACC 
TGTGACTGTG GGGCAGGTTC TACTGGGGGA GTGACAGGTG GTTTTATCCC AGTTCCTGAT 
GGCTCAGAAG GAACAATTCA TCAGTGGGGA ATTGAAGGAG CCCATCCTGA AGACAAGGAA 
ATCACAAATA TTTGTGTGCC TCCTGTAACA GCCAATGGAG CCGATTTCAT GGAAAGTTCT 
GTTTGTACAA ATACGTATGC CAGAGGCACA GCGGTGGAAG GCACTTCAGG AATGGAAATG 
ACCACTAAGC TTGGAGCAGC CACTGAATCT GGAGGTGCTG CAGGCTTTGC AACAGGGACA 
GTGTCAGGAG CTGCTTCAGG ATTCGGAGCA GCCACTGGAG TTGGCATCTG TTCCTCAGGG 
CAGTCTGGAA CCATGAGAAC AAGGCATTCC ACTGGAGGAA CCAATAAGGA CTACGCTGAT 
GGGGCGATAA GCATGAATTT TCTGGACTCC TACTTTTCTC AGAAAGCATT TGCCTGTGCG 
GAGGAAGACG ATGGCCAGGA AGCAAATGAC TGCTTGTTGA TCTATGATAA TGAAGGCGCA 
GATGCCACTG GTTCTCCTGT GGGCTCCGTG GGTTGTTGCA GTTTTATTGC TGATGACCTG 
GATGACAGCT TCTTGGACTC ACTTGGACCC AAATTTAAAA AACTTGCAGA GATAAGCCTT 
GGTGTTGATG GTGAAGGCAA AGAAGTTCAG CCACCCTCTA AAGACAGCGG TTATGGGATT 
GAATCCTGTG GCCATCCCAT AGAAGTCCAG CAGACAGGAT TTGTTAAGTG CCAGACTTTG 
TCAGGAAGTC AAGGAGCTTC TGCTTTGTCC ACCTCTGGGT CTGTCCAGCC AGCTGTTTCC 
ATCCCTGACC CTCTGCAGCA TGGTAACTAT TTAGTAACGG AGACTTACTC GGCTTCTGGT 
TCCCTCGTGC AACCTTCCAC TGCAGGCTTT GATCCACTTC TCACACAAAA TGTGATAGTG 
ACAGAAAGGG TGATCTGTCC CATTTCCAGT GTTCCTGGCA ACCTAGCTGG CCCAACGCAG 
CTACGAGGGT CACATACTAT GCTCTGTACA GAGGATCCTT GCTCCCGTCT AATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524152.1
CDS	110..3106
Translation	MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQTLSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTMLCTEDPCSRLI

Target ORF information:

RefSeq Version	XM_011525850.1
Organism	Homo sapiens(human)
Definition	Homo sapiens desmoglein 3 (DSG3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011525850.1

ORF Insert Sequence:

ATGATGGGGC TCTTCCCCAG AACTACAGGG GCTCTGGCCA TCTTCGTGGT GGTCATATTG 
GTTCATGGAG AATTGCGAAT AGAGACTAAA GGTCAATATG ATGAAGAAGA GATGACTATG 
CAACAAGCTA AAAGAAGGCA AAAACGTGAA TGGGTGAAAT TTGCCAAACC CTGCAGAGAA 
GGAGAAGATA ACTCAAAAAG AAACCCAATT GCCAAGATTA CTTCAGATTA CCAAGCAACC 
CAGAAAATCA CCTACCGAAT CTCTGGAGTG GGAATCGATC AGCCGCCTTT TGGAATCTTT 
GTTGTTGACA AAAACACTGG AGATATTAAC ATAACAGCTA TAGTCGACCG GGAGGAAACT 
CCAAGCTTCC TGATCACATG TCGGGCTCTA AATGCCCAAG GACTAGATGT AGAGAAACCA 
CTTATACTAA CGGTTAAAAT TTTGGATATT AATGATAATC CTCCAGTATT TTCACAACAA 
ATTTTCATGG GTGAAATTGA AGAAAATAGT GCCTCAAACT CACTGGTGAT GATACTAAAT 
GCCACAGATG CAGATGAACC AAACCACTTG AATTCTAAAA TTGCCTTCAA AATTGTCTCT 
CAGGAACCAG CAGGCACACC CATGTTCCTC CTAAGCAGAA ACACTGGGGA AGTCCGTACT 
TTGACCAATT CTCTTGACCG AGAGCAAGCT AGCAGCTATC GTCTGGTTGT GAGTGGTGCA 
GACAAAGATG GAGAAGGACT ATCAACTCAA TGTGAATGTA ATATTAAAGT GAAAGATGTC 
AACGATAACT TCCCAATGTT TAGAGACTCT CAGTATTCAG CACGTATTGA AGAAAATATT 
TTAAGTTCTG AATTACTTCG ATTTCAAGTA ACAGATTTGG ATGAAGAGTA CACAGATAAT 
TGGCTTGCAG TATATTTCTT TACCTCTGGG AATGAAGGAA ATTGGTTTGA AATACAAACT 
GATCCTAGAA CTAATGAAGG CATCCTGAAA GTGGTGAAGG CTCTAGATTA TGAACAACTA 
CAAAGCGTGA AACTTAGTAT TGCTGTCAAA AACAAAGCTG AATTTCACCA ATCAGTTATC 
TCTCGATACC GAGTTCAGTC AACCCCAGTC ACAATTCAGG TAATAAATGT AAGAGAAGGA 
ATTGCATTCC GTCCTGCTTC CAAGACATTT ACTGTGCAAA AAGGCATAAG TAGCAAAAAA 
TTGGTGGATT ATATCCTGGG AACATATCAA GCCATCGATG AGGACACTAA CAAAGCTGCC 
TCAAATGTCA AATATGTCAT GGGACGTAAC GATGGTGGAT ACCTAATGAT TGATTCAAAA 
ACTGCTGAAA TCAAATTTGT CAAAAATATG AACCGAGATT CTACTTTCAT AGTTAACAAA 
ACAATCACAG CTGAGGTTCT GGCCATAGAT GAATACACGG GTAAAACTTC TACAGGCACG 
GTATATGTTA GAGTACCCGA TTTCAATGAC AATTGTCCAA CAGCTGTCCT CGAAAAAGAT 
GCAGTTTGCA GTTCTTCACC TTCCGTGGTT GTCTCCGCTA GAACACTGAA TAATAGATAC 
ACTGGCCCCT ATACATTTGC ACTGGAAGAT CAACCTGTAA AGTTGCCTGC CGTATGGAGT 
ATCACAACCC TCAATGCTAC CTCGGCCCTC CTCAGAGCCC AGGAACAGAT ACCTCCTGGA 
GTATACCACA TCTCCCTGGT ACTTACAGAC AGTCAGAACA ATCGGTGTGA GATGCCACGC 
AGCTTGACAC TGGAAGTCTG TCAGTGTGAC AACAGGGGCA TCTGTGGAAC TTCTTACCCA 
ACCACAAGCC CTGGGACCAG GTATGGCAGG CCGCACTCAG GGAGGCTGGG GCCTGCCGCC 
ATCGGCCTGC TGCTCCTTGG TCTCCTGCTG CTGCTGTTGG CCCCCCTTCT GCTGTTGACC 
TGTGACTGTG GGGCAGGTTC TACTGGGGGA GTGACAGGTG GTTTTATCCC AGTTCCTGAT 
GGCTCAGAAG GAACAATTCA TCAGTGGGGA ATTGAAGGAG CCCATCCTGA AGACAAGGAA 
ATCACAAATA TTTGTGTGCC TCCTGTAACA GCCAATGGAG CCGATTTCAT GGAAAGTTCT 
GTTTGTACAA ATACGTATGC CAGAGGCACA GCGGTGGAAG GCACTTCAGG AATGGAAATG 
ACCACTAAGC TTGGAGCAGC CACTGAATCT GGAGGTGCTG CAGGCTTTGC AACAGGGACA 
GTGTCAGGAG CTGCTTCAGG ATTCGGAGCA GCCACTGGAG TTGGCATCTG TTCCTCAGGG 
CAGTCTGGAA CCATGAGAAC AAGGCATTCC ACTGGAGGAA CCAATAAGGA CTACGCTGAT 
GGGGCGATAA GCATGAATTT TCTGGACTCC TACTTTTCTC AGAAAGCATT TGCCTGTGCG 
GAGGAAGACG ATGGCCAGGA AGCAAATGAC TGCTTGTTGA TCTATGATAA TGAAGGCGCA 
GATGCCACTG GTTCTCCTGT GGGCTCCGTG GGTTGTTGCA GTTTTATTGC TGATGACCTG 
GATGACAGCT TCTTGGACTC ACTTGGACCC AAATTTAAAA AACTTGCAGA GATAAGCCTT 
GGTGTTGATG GTGAAGGCAA AGAAGTTCAG CCACCCTCTA AAGACAGCGG TTATGGGATT 
GAATCCTGTG GCCATCCCAT AGAAGTCCAG CAGACAGGAT TTGTTAAGTG CCAGACTTTG 
TCAGGAAGTC AAGGAGCTTC TGCTTTGTCC ACCTCTGGGT CTGTCCAGCC AGCTGTTTCC 
ATCCCTGACC CTCTGCAGCA TGGTAACTAT TTAGTAACGG AGACTTACTC GGCTTCTGGT 
TCCCTCGTGC AACCTTCCAC TGCAGGCTTT GATCCACTTC TCACACAAAA TGTGATAGTG 
ACAGAAAGGG TGATCTGTCC CATTTCCAGT GTTCCTGGCA ACCTAGCTGG CCCAACGCAG 
CTACGAGGGT CACATACTAT GCTCTGTACA GAGGATCCTT GCTCCCGTCT AATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSG3 ( XM_011525850.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011524152.1 Homo sapiens desmoglein 3 (DSG3), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu57381
Clone ID Related Accession (Same CDS sequence)	XM_011525850.1 , XM_011525850.2
Accession Version	XM_011525850.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2997bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	desmoglein-3 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000018.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011525850.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGATGGGGC TCTTCCCCAG AACTACAGGG GCTCTGGCCA TCTTCGTGGT GGTCATATTG 
GTTCATGGAG AATTGCGAAT AGAGACTAAA GGTCAATATG ATGAAGAAGA GATGACTATG 
CAACAAGCTA AAAGAAGGCA AAAACGTGAA TGGGTGAAAT TTGCCAAACC CTGCAGAGAA 
GGAGAAGATA ACTCAAAAAG AAACCCAATT GCCAAGATTA CTTCAGATTA CCAAGCAACC 
CAGAAAATCA CCTACCGAAT CTCTGGAGTG GGAATCGATC AGCCGCCTTT TGGAATCTTT 
GTTGTTGACA AAAACACTGG AGATATTAAC ATAACAGCTA TAGTCGACCG GGAGGAAACT 
CCAAGCTTCC TGATCACATG TCGGGCTCTA AATGCCCAAG GACTAGATGT AGAGAAACCA 
CTTATACTAA CGGTTAAAAT TTTGGATATT AATGATAATC CTCCAGTATT TTCACAACAA 
ATTTTCATGG GTGAAATTGA AGAAAATAGT GCCTCAAACT CACTGGTGAT GATACTAAAT 
GCCACAGATG CAGATGAACC AAACCACTTG AATTCTAAAA TTGCCTTCAA AATTGTCTCT 
CAGGAACCAG CAGGCACACC CATGTTCCTC CTAAGCAGAA ACACTGGGGA AGTCCGTACT 
TTGACCAATT CTCTTGACCG AGAGCAAGCT AGCAGCTATC GTCTGGTTGT GAGTGGTGCA 
GACAAAGATG GAGAAGGACT ATCAACTCAA TGTGAATGTA ATATTAAAGT GAAAGATGTC 
AACGATAACT TCCCAATGTT TAGAGACTCT CAGTATTCAG CACGTATTGA AGAAAATATT 
TTAAGTTCTG AATTACTTCG ATTTCAAGTA ACAGATTTGG ATGAAGAGTA CACAGATAAT 
TGGCTTGCAG TATATTTCTT TACCTCTGGG AATGAAGGAA ATTGGTTTGA AATACAAACT 
GATCCTAGAA CTAATGAAGG CATCCTGAAA GTGGTGAAGG CTCTAGATTA TGAACAACTA 
CAAAGCGTGA AACTTAGTAT TGCTGTCAAA AACAAAGCTG AATTTCACCA ATCAGTTATC 
TCTCGATACC GAGTTCAGTC AACCCCAGTC ACAATTCAGG TAATAAATGT AAGAGAAGGA 
ATTGCATTCC GTCCTGCTTC CAAGACATTT ACTGTGCAAA AAGGCATAAG TAGCAAAAAA 
TTGGTGGATT ATATCCTGGG AACATATCAA GCCATCGATG AGGACACTAA CAAAGCTGCC 
TCAAATGTCA AATATGTCAT GGGACGTAAC GATGGTGGAT ACCTAATGAT TGATTCAAAA 
ACTGCTGAAA TCAAATTTGT CAAAAATATG AACCGAGATT CTACTTTCAT AGTTAACAAA 
ACAATCACAG CTGAGGTTCT GGCCATAGAT GAATACACGG GTAAAACTTC TACAGGCACG 
GTATATGTTA GAGTACCCGA TTTCAATGAC AATTGTCCAA CAGCTGTCCT CGAAAAAGAT 
GCAGTTTGCA GTTCTTCACC TTCCGTGGTT GTCTCCGCTA GAACACTGAA TAATAGATAC 
ACTGGCCCCT ATACATTTGC ACTGGAAGAT CAACCTGTAA AGTTGCCTGC CGTATGGAGT 
ATCACAACCC TCAATGCTAC CTCGGCCCTC CTCAGAGCCC AGGAACAGAT ACCTCCTGGA 
GTATACCACA TCTCCCTGGT ACTTACAGAC AGTCAGAACA ATCGGTGTGA GATGCCACGC 
AGCTTGACAC TGGAAGTCTG TCAGTGTGAC AACAGGGGCA TCTGTGGAAC TTCTTACCCA 
ACCACAAGCC CTGGGACCAG GTATGGCAGG CCGCACTCAG GGAGGCTGGG GCCTGCCGCC 
ATCGGCCTGC TGCTCCTTGG TCTCCTGCTG CTGCTGTTGG CCCCCCTTCT GCTGTTGACC 
TGTGACTGTG GGGCAGGTTC TACTGGGGGA GTGACAGGTG GTTTTATCCC AGTTCCTGAT 
GGCTCAGAAG GAACAATTCA TCAGTGGGGA ATTGAAGGAG CCCATCCTGA AGACAAGGAA 
ATCACAAATA TTTGTGTGCC TCCTGTAACA GCCAATGGAG CCGATTTCAT GGAAAGTTCT 
GTTTGTACAA ATACGTATGC CAGAGGCACA GCGGTGGAAG GCACTTCAGG AATGGAAATG 
ACCACTAAGC TTGGAGCAGC CACTGAATCT GGAGGTGCTG CAGGCTTTGC AACAGGGACA 
GTGTCAGGAG CTGCTTCAGG ATTCGGAGCA GCCACTGGAG TTGGCATCTG TTCCTCAGGG 
CAGTCTGGAA CCATGAGAAC AAGGCATTCC ACTGGAGGAA CCAATAAGGA CTACGCTGAT 
GGGGCGATAA GCATGAATTT TCTGGACTCC TACTTTTCTC AGAAAGCATT TGCCTGTGCG 
GAGGAAGACG ATGGCCAGGA AGCAAATGAC TGCTTGTTGA TCTATGATAA TGAAGGCGCA 
GATGCCACTG GTTCTCCTGT GGGCTCCGTG GGTTGTTGCA GTTTTATTGC TGATGACCTG 
GATGACAGCT TCTTGGACTC ACTTGGACCC AAATTTAAAA AACTTGCAGA GATAAGCCTT 
GGTGTTGATG GTGAAGGCAA AGAAGTTCAG CCACCCTCTA AAGACAGCGG TTATGGGATT 
GAATCCTGTG GCCATCCCAT AGAAGTCCAG CAGACAGGAT TTGTTAAGTG CCAGACTTTG 
TCAGGAAGTC AAGGAGCTTC TGCTTTGTCC ACCTCTGGGT CTGTCCAGCC AGCTGTTTCC 
ATCCCTGACC CTCTGCAGCA TGGTAACTAT TTAGTAACGG AGACTTACTC GGCTTCTGGT 
TCCCTCGTGC AACCTTCCAC TGCAGGCTTT GATCCACTTC TCACACAAAA TGTGATAGTG 
ACAGAAAGGG TGATCTGTCC CATTTCCAGT GTTCCTGGCA ACCTAGCTGG CCCAACGCAG 
CTACGAGGGT CACATACTAT GCTCTGTACA GAGGATCCTT GCTCCCGTCT AATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011524152.1
CDS	110..3106
Translation	MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCREGEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREETPSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILNATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGADKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDNWLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVISRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAASNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGTVYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWSITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYPTTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPDGSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSVCTNTYARGTAVEGTSGMEMTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYADGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADDLDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQTLSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVIVTERVICPISSVPGNLAGPTQLRGSHTMLCTEDPCSRLI

Target ORF information:

RefSeq Version	XM_011525850.2
Organism	Homo sapiens(human)
Definition	Homo sapiens desmoglein 3 (DSG3), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011525850.2

ORF Insert Sequence:

ATGATGGGGC TCTTCCCCAG AACTACAGGG GCTCTGGCCA TCTTCGTGGT GGTCATATTG 
GTTCATGGAG AATTGCGAAT AGAGACTAAA GGTCAATATG ATGAAGAAGA GATGACTATG 
CAACAAGCTA AAAGAAGGCA AAAACGTGAA TGGGTGAAAT TTGCCAAACC CTGCAGAGAA 
GGAGAAGATA ACTCAAAAAG AAACCCAATT GCCAAGATTA CTTCAGATTA CCAAGCAACC 
CAGAAAATCA CCTACCGAAT CTCTGGAGTG GGAATCGATC AGCCGCCTTT TGGAATCTTT 
GTTGTTGACA AAAACACTGG AGATATTAAC ATAACAGCTA TAGTCGACCG GGAGGAAACT 
CCAAGCTTCC TGATCACATG TCGGGCTCTA AATGCCCAAG GACTAGATGT AGAGAAACCA 
CTTATACTAA CGGTTAAAAT TTTGGATATT AATGATAATC CTCCAGTATT TTCACAACAA 
ATTTTCATGG GTGAAATTGA AGAAAATAGT GCCTCAAACT CACTGGTGAT GATACTAAAT 
GCCACAGATG CAGATGAACC AAACCACTTG AATTCTAAAA TTGCCTTCAA AATTGTCTCT 
CAGGAACCAG CAGGCACACC CATGTTCCTC CTAAGCAGAA ACACTGGGGA AGTCCGTACT 
TTGACCAATT CTCTTGACCG AGAGCAAGCT AGCAGCTATC GTCTGGTTGT GAGTGGTGCA 
GACAAAGATG GAGAAGGACT ATCAACTCAA TGTGAATGTA ATATTAAAGT GAAAGATGTC 
AACGATAACT TCCCAATGTT TAGAGACTCT CAGTATTCAG CACGTATTGA AGAAAATATT 
TTAAGTTCTG AATTACTTCG ATTTCAAGTA ACAGATTTGG ATGAAGAGTA CACAGATAAT 
TGGCTTGCAG TATATTTCTT TACCTCTGGG AATGAAGGAA ATTGGTTTGA AATACAAACT 
GATCCTAGAA CTAATGAAGG CATCCTGAAA GTGGTGAAGG CTCTAGATTA TGAACAACTA 
CAAAGCGTGA AACTTAGTAT TGCTGTCAAA AACAAAGCTG AATTTCACCA ATCAGTTATC 
TCTCGATACC GAGTTCAGTC AACCCCAGTC ACAATTCAGG TAATAAATGT AAGAGAAGGA 
ATTGCATTCC GTCCTGCTTC CAAGACATTT ACTGTGCAAA AAGGCATAAG TAGCAAAAAA 
TTGGTGGATT ATATCCTGGG AACATATCAA GCCATCGATG AGGACACTAA CAAAGCTGCC 
TCAAATGTCA AATATGTCAT GGGACGTAAC GATGGTGGAT ACCTAATGAT TGATTCAAAA 
ACTGCTGAAA TCAAATTTGT CAAAAATATG AACCGAGATT CTACTTTCAT AGTTAACAAA 
ACAATCACAG CTGAGGTTCT GGCCATAGAT GAATACACGG GTAAAACTTC TACAGGCACG 
GTATATGTTA GAGTACCCGA TTTCAATGAC AATTGTCCAA CAGCTGTCCT CGAAAAAGAT 
GCAGTTTGCA GTTCTTCACC TTCCGTGGTT GTCTCCGCTA GAACACTGAA TAATAGATAC 
ACTGGCCCCT ATACATTTGC ACTGGAAGAT CAACCTGTAA AGTTGCCTGC CGTATGGAGT 
ATCACAACCC TCAATGCTAC CTCGGCCCTC CTCAGAGCCC AGGAACAGAT ACCTCCTGGA 
GTATACCACA TCTCCCTGGT ACTTACAGAC AGTCAGAACA ATCGGTGTGA GATGCCACGC 
AGCTTGACAC TGGAAGTCTG TCAGTGTGAC AACAGGGGCA TCTGTGGAAC TTCTTACCCA 
ACCACAAGCC CTGGGACCAG GTATGGCAGG CCGCACTCAG GGAGGCTGGG GCCTGCCGCC 
ATCGGCCTGC TGCTCCTTGG TCTCCTGCTG CTGCTGTTGG CCCCCCTTCT GCTGTTGACC 
TGTGACTGTG GGGCAGGTTC TACTGGGGGA GTGACAGGTG GTTTTATCCC AGTTCCTGAT 
GGCTCAGAAG GAACAATTCA TCAGTGGGGA ATTGAAGGAG CCCATCCTGA AGACAAGGAA 
ATCACAAATA TTTGTGTGCC TCCTGTAACA GCCAATGGAG CCGATTTCAT GGAAAGTTCT 
GTTTGTACAA ATACGTATGC CAGAGGCACA GCGGTGGAAG GCACTTCAGG AATGGAAATG 
ACCACTAAGC TTGGAGCAGC CACTGAATCT GGAGGTGCTG CAGGCTTTGC AACAGGGACA 
GTGTCAGGAG CTGCTTCAGG ATTCGGAGCA GCCACTGGAG TTGGCATCTG TTCCTCAGGG 
CAGTCTGGAA CCATGAGAAC AAGGCATTCC ACTGGAGGAA CCAATAAGGA CTACGCTGAT 
GGGGCGATAA GCATGAATTT TCTGGACTCC TACTTTTCTC AGAAAGCATT TGCCTGTGCG 
GAGGAAGACG ATGGCCAGGA AGCAAATGAC TGCTTGTTGA TCTATGATAA TGAAGGCGCA 
GATGCCACTG GTTCTCCTGT GGGCTCCGTG GGTTGTTGCA GTTTTATTGC TGATGACCTG 
GATGACAGCT TCTTGGACTC ACTTGGACCC AAATTTAAAA AACTTGCAGA GATAAGCCTT 
GGTGTTGATG GTGAAGGCAA AGAAGTTCAG CCACCCTCTA AAGACAGCGG TTATGGGATT 
GAATCCTGTG GCCATCCCAT AGAAGTCCAG CAGACAGGAT TTGTTAAGTG CCAGACTTTG 
TCAGGAAGTC AAGGAGCTTC TGCTTTGTCC ACCTCTGGGT CTGTCCAGCC AGCTGTTTCC 
ATCCCTGACC CTCTGCAGCA TGGTAACTAT TTAGTAACGG AGACTTACTC GGCTTCTGGT 
TCCCTCGTGC AACCTTCCAC TGCAGGCTTT GATCCACTTC TCACACAAAA TGTGATAGTG 
ACAGAAAGGG TGATCTGTCC CATTTCCAGT GTTCCTGGCA ACCTAGCTGG CCCAACGCAG 
CTACGAGGGT CACATACTAT GCTCTGTACA GAGGATCCTT GCTCCCGTCT AATATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Desmoglein 3 Order and Dynamics in Desmosomes Determined by Fluorescence Polarization Microscopy.
Biophysical journal113(11)2519-2529(2017 Dec)
Bartle EI,Urner TM,Raju SS,Mattheyses AL

Different signaling patterns contribute to loss of keratinocyte cohesion dependent on autoantibody profile in pemphigus.
Scientific reports7(1)3579(2017 Jun)
Walter E,Vielmuth F,Rotkopf L,S?rdy M,Horv?th ON,Goebeler M,Schmidt E,Eming R,Hertl M,Spindler V,Waschke J

Loss of flotillin expression results in weakened desmosomal adhesion and Pemphigus vulgaris-like localisation of desmoglein-3 in human keratinocytes.
Scientific reports628820(2016 Jun)
V?llner F,Ali J,Kurrle N,Exner Y,Eming R,Hertl M,Banning A,Tikkanen R

Pathogenicity and Epitope Characteristics Do Not Differ in IgG Subclass-Switched Anti-Desmoglein 3 IgG1 and IgG4 Autoantibodies in Pemphigus Vulgaris.
PloS one11(6)e0156800(2016)
Lo AS,Mao X,Mukherjee EM,Ellebrecht CT,Yu X,Posner MR,Payne AS,Cavacini LA

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DSG3 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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