DSC1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DSC1
Entrez Gene ID	1823
Full Name	desmocollin 1
Synonyms	CDHF1,DG2/DG3
General protein information	Preferred Names desmocollin 1 Names desmocollin-1 cadherin family member 1 desmosomal glycoprotein 2/3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 18 Map Location: 18q12.1
Summary	The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. A subtype of IgA pemphigus, a life-threatening autoimmune disease, is characterized by the presence of autoantibodies that target the encoded protein. The desmosomal family members are arranged in two clusters on chromosome 18. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protein. [provided by RefSeq, Nov 2015].
Disorder MIM:	125643

mRNA and Protein(s)

mRNA	Protein	Name
NM_024421.2	NP_077739.1	desmocollin-1 isoform Dsc1a preproprotein
NM_004948.3	NP_004939.1	desmocollin-1 isoform Dsc1b precursor

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Dsc1	NP_038532.3
Danio rerio (zebrafish)	dsc2l	XP_688578.4
Homo sapiens (human)	DSC1	NP_077739.1
Pan troglodytes (chimpanzee)	DSC1	XP_512078.2
Canis lupus familiaris (dog)	DSC1	XP_547623.3
Bos taurus (cattle)	DSC1	NP_776469.1
Rattus norvegicus (Norway rat)	Dsc1	XP_006254505.1
	DSC1	XP_001098098.2

Gene Ontology
Bibliography

Related articles in PubMed

Human gingiva transcriptome during wound healing.
Wang Y, Tatakis DN
Journal of clinical periodontology44(4)394-402(2017 Apr)

Lower DSC1 expression is related to the poor differentiation and prognosis of head and neck squamous cell carcinoma (HNSCC).
Wang Y, Chen C, Wang X, Jin F, Liu Y, Liu H, Li T, Fu J
Journal of cancer research and clinical oncology142(12)2461-2468(2016 Dec)

Expression of desmosomal proteins in acantholytic squamous cell carcinoma of the skin.
Jur?i? V, Kukovi? J, Zidar N
Histology and histopathology30(8)945-53(2015 Aug)

Pemphigus herpetiformis with IgG autoantibodies to desmoglein 1 and desmocollin 1.
On HR, Hashimoto T, Kim SC
The British journal of dermatology172(4)1144-6(2015 Apr)

Transcriptional regulation of genes involved in keratinocyte differentiation by human papillomavirus 16 oncoproteins.
Gy?ngy?si E, Szalm?s A, Ferenczi A, P?liska S, K?nya J, Veress G
Archives of virology160(2)389-98(2015 Feb)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DSC1 expression is significantly downregulated in human masticatory mucosa during wound healing
Title: Human gingiva transcriptome during wound healing.

Increased expression of DSC1 can promote the occurrence of head and neck squamous cell carcinoma (HNSCC) and is associated with tumor. The increased expression of DSC1 also indicates a poor prognosis of the patients with HNSCC.
Title: Lower DSC1 expression is related to the poor differentiation and prognosis of head and neck squamous cell carcinoma (HNSCC).

Low expression of DSC 1, 2, and 3 was observed in 55, 54, and 79 % of liver metastases.
Title: The influence of desmocollin 1-3 expression on prognosis after curative resection of colorectal liver metastases.

High expression of desmocollin 1 (DSC1) was observed in 41.6%, DSC2 in 58.0%, DSC3 in 61.4%, E-cadherin in 71.4%, CDX2 in 58.0%, PITX1 in 55.0%, CDK4 in 0.2%, TLE1 in 1.3%, Factor H in 42.5%, and MDM2 in 0.2% of colorectal carcinomas.
Title: Loss of desmocollin 1-3 and homeobox genes PITX1 and CDX2 are associated with tumor progression and survival in colorectal carcinoma.

Increased Dsc1 protein is associated with colorectal cancer
Title: Desmocollin switching in colorectal cancer.

The following DSC1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DSC1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu18942	NM_004948.3 Latest version!	Homo sapiens desmocollin 1 (DSC1), transcript variant Dsc1b, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00
OHu25076	NM_024421.2 Latest version!	Homo sapiens desmocollin 1 (DSC1), transcript variant Dsc1a, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$475.30 $679.00

ORF Online Only Promotion

Next-day Shipping ORF Clones ( in default vector with tag)
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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DSC1 ( NM_004948.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004939.1 Homo sapiens desmocollin 1 (DSC1), transcript variant Dsc1b, mRNA.

Price & Availability↑

CloneID	OHu18942
Clone ID Related Accession (Same CDS sequence)	NM_004948.3
Accession Version	NM_004948.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2523bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	desmocollin-1 isoform Dsc1b precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X72925.1, Z34522.1, AC012417.13 and CU447407.1. This sequence is a reference standard in the RefSeqGene project. On Sep 19, 2008 this sequence version replaced NM_004948.2. Transcript Variant: This variant (Dsc1b) includes an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to isoform Dsc1a. The encoded isoform (Dsc1b) is shorter than isoform Dsc1a. This isoform (Dsc1b) may undergo proteolytic processing similar to isoform Dsc1a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: X72925.1, Z34522.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCTCTGG CCTCTGCTGC CCCAGGGAGC ATCTTCTGTA AGCAGCTCCT TTTCTCTCTC 
CTGGTTTTAA CATTACTTTG CGATGCTTGT CAGAAAGTTT ATCTTCGAGT TCCTTCTCAT 
CTTCAGGCTG AAACACTTGT AGGCAAAGTG AATCTGGAGG AGTGTCTCAA GTCGGCCAGC 
CTAATCCGGT CCAGTGACCC TGCCTTCAGA ATTCTAGAAG ATGGCTCAAT TTACACAACA 
CATGACCTCA TTTTGTCTTC TGAAAGGAAA AGTTTTTCCA TTTTCCTTTC AGATGGTCAG 
AGACGGGAAC AACAAGAGAT AAAAGTTGTA CTGTCAGCAA GAGAAAACAA GTCTCCTAAG 
AAGAGACATA CCAAAGACAC AGCCCTCAAG CGCAGCAAGA GACGATGGGC TCCTATTCCA 
GCTTCATTGA TGGAGAACTC GTTGGGTCCA TTTCCACAAC ACGTTCAGCA GATCCAATCT 
GATGCTGCAC AGAATTACAC CATCTTTTAT TCCATAAGTG GGCCAGGCGT GGACAAAGAA 
CCCTTCAATT TGTTTTACAT AGAGAAAGAC ACTGGGGATA TCTTTTGTAC AAGGAGCATT 
GACCGTGAGA AATATGAACA GTTTGCGTTA TATGGCTATG CAACAACTGC AGATGGCTAT 
GCACCAGAAT ATCCACTCCC TTTGATCATC AAAATTGAAG ATGATAATGA TAACGCCCCA 
TATTTTGAAC ACAGAGTGAC TATCTTTACT GTGCCTGAAA ATTGCCGATC CGGAACTTCA 
GTGGGAAAAG TGACCGCCAC AGACCTTGAC GAACCTGACA CTCTCCATAC TCGTCTGAAA 
TATAAAATCT TACAACAAAT CCCAGATCAT CCAAAGCATT TCTCCATACA CCCAGATACC 
GGTGTCATCA CCACAACTAC ACCTTTTCTG GATAGAGAAA AATGTGATAC TTACCAGTTA 
ATAATGGAAG TGCGAGACAT GGGTGGTCAG CCTTTCGGTT TATTTAATAC AGGAACAATT 
ACTATTTCAC TTGAGGATGA AAATGACAAT CCACCATCTT TCACAGAAAC TTCTTATGTT 
ACAGAAGTAG AAGAAAACAG AATTGACGTG GAGATTTTAC GAATGAAGGT ACAGGATCAG 
GATTTGCCAA ACACTCCTCA CTCAAAGGCT GTATACAAAA TCCTACAAGG AAATGAAAAT 
GGAAACTTCA TAATTAGCAC AGATCCAAAT ACAAATGAAG GAGTGCTGTG TGTTGTCAAG 
CCATTGAACT ATGAAGTCAA TCGCCAAGTT ATTTTGCAAG TTGGTGTCAT TAACGAGGCA 
CAATTCTCTA AAGCAGCGAG CTCACAAACT CCTACAATGT GCACTACAAC TGTCACCGTT 
AAAATTATAG ACAGTGATGA GGGCCCTGAA TGCCACCCTC CAGTGAAAGT TATTCAGAGT 
CAAGATGGCT TCCCAGCTGG CCAAGAACTC CTTGGATACA AAGCACTGGA CCCGGAAATA 
TCCAGTGGTG AAGGCTTAAG GTATCAGAAG TTAGGGGATG AAGATAACTG GTTTGAAATT 
AATCAACACA CTGGCGACTT GAGAACTCTA AAAGTACTAG ATAGAGAATC CAAATTTGTA 
AAAAACAACC AATACAATAT TTCAGTTGTT GCAGTGGATG CAGTTGGCCG ATCTTGCACT 
GGAACATTAG TAGTTCATTT GGATGATTAC AACGATCACG CACCTCAAAT TGACAAAGAA 
GTGACCATTT GTCAGAATAA TGAGGATTTT GCTGTTCTGA AACCTGTAGA TCCAGATGGA 
CCTGAAAATG GACCACCTTT TCAATTCTTT CTGGATAATT CTGCCAGTAA AAACTGGAAC 
ATAGAAGAAA AGGATGGTAA AACTGCCATT CTTCGTCAAC GGCAAAATCT TGATTATAAC 
TATTATTCTG TGCCTATTCA AATAAAAGAC AGGCATGGTT TAGTTGCAAC ACATATGTTA 
ACAGTGAGAG TATGTGACTG TTCAACTCCA TCTGAGTGTA GAATGAAGGA TAAAAGTACA 
AGAGACGTTA GACCAAATGT AATACTTGGA AGATGGGCTA TTCTTGCTAT GGTGTTGGGT 
TCTGTATTGT TATTATGTAT TCTGTTTACA TGTTTCTGTG TCACTGCTAA GAGAACAGTC 
AAGAAATGTT TTCCAGAAGA CATAGCCCAG CAAAATTTAA TTGTATCAAA TACTGAAGGA 
CCTGGAGAAG AAGTAACGGA AGCAAATATT AGACTCCCCA TGCAGACATC CAACATTTGT 
GACACAAGCA TGTCTGTTGG TACTGTTGGT GGCCAGGGAA TCAAAACACA GCAAAGTTTT 
GAGATGGTCA AAGGAGGCTA CACTTTGGAT TCCAACAAAG GAGGTGGACA TCAGACCTTG 
GAGTCCGTCA AGGGAGTGGG GCAGGGAGAT ACTGGCAGAT ATGCGTACAC GGACTGGCAG 
AGTTTCACCC AACCTCGGCT TGGCGAAGAA TCCATTAGAG GACACACTCT GATTAAAAAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004939.1
CDS	263..2785
Translation	MALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSASLIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPDGPENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTVKKCFPEDIAQQNLIVSNTEGPGEEVTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSFEMVKGGYTLDSNKGGGHQTLESVKGVGQGDTGRYAYTDWQSFTQPRLGEESIRGHTLIKN

Target ORF information:

RefSeq Version	NM_004948.3
Organism	Homo sapiens(human)
Definition	Homo sapiens desmocollin 1 (DSC1), transcript variant Dsc1b, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004948.3

ORF Insert Sequence:

ATGGCTCTGG CCTCTGCTGC CCCAGGGAGC ATCTTCTGTA AGCAGCTCCT TTTCTCTCTC 
CTGGTTTTAA CATTACTTTG CGATGCTTGT CAGAAAGTTT ATCTTCGAGT TCCTTCTCAT 
CTTCAGGCTG AAACACTTGT AGGCAAAGTG AATCTGGAGG AGTGTCTCAA GTCGGCCAGC 
CTAATCCGGT CCAGTGACCC TGCCTTCAGA ATTCTAGAAG ATGGCTCAAT TTACACAACA 
CATGACCTCA TTTTGTCTTC TGAAAGGAAA AGTTTTTCCA TTTTCCTTTC AGATGGTCAG 
AGACGGGAAC AACAAGAGAT AAAAGTTGTA CTGTCAGCAA GAGAAAACAA GTCTCCTAAG 
AAGAGACATA CCAAAGACAC AGCCCTCAAG CGCAGCAAGA GACGATGGGC TCCTATTCCA 
GCTTCATTGA TGGAGAACTC GTTGGGTCCA TTTCCACAAC ACGTTCAGCA GATCCAATCT 
GATGCTGCAC AGAATTACAC CATCTTTTAT TCCATAAGTG GGCCAGGCGT GGACAAAGAA 
CCCTTCAATT TGTTTTACAT AGAGAAAGAC ACTGGGGATA TCTTTTGTAC AAGGAGCATT 
GACCGTGAGA AATATGAACA GTTTGCGTTA TATGGCTATG CAACAACTGC AGATGGCTAT 
GCACCAGAAT ATCCACTCCC TTTGATCATC AAAATTGAAG ATGATAATGA TAACGCCCCA 
TATTTTGAAC ACAGAGTGAC TATCTTTACT GTGCCTGAAA ATTGCCGATC CGGAACTTCA 
GTGGGAAAAG TGACCGCCAC AGACCTTGAC GAACCTGACA CTCTCCATAC TCGTCTGAAA 
TATAAAATCT TACAACAAAT CCCAGATCAT CCAAAGCATT TCTCCATACA CCCAGATACC 
GGTGTCATCA CCACAACTAC ACCTTTTCTG GATAGAGAAA AATGTGATAC TTACCAGTTA 
ATAATGGAAG TGCGAGACAT GGGTGGTCAG CCTTTCGGTT TATTTAATAC AGGAACAATT 
ACTATTTCAC TTGAGGATGA AAATGACAAT CCACCATCTT TCACAGAAAC TTCTTATGTT 
ACAGAAGTAG AAGAAAACAG AATTGACGTG GAGATTTTAC GAATGAAGGT ACAGGATCAG 
GATTTGCCAA ACACTCCTCA CTCAAAGGCT GTATACAAAA TCCTACAAGG AAATGAAAAT 
GGAAACTTCA TAATTAGCAC AGATCCAAAT ACAAATGAAG GAGTGCTGTG TGTTGTCAAG 
CCATTGAACT ATGAAGTCAA TCGCCAAGTT ATTTTGCAAG TTGGTGTCAT TAACGAGGCA 
CAATTCTCTA AAGCAGCGAG CTCACAAACT CCTACAATGT GCACTACAAC TGTCACCGTT 
AAAATTATAG ACAGTGATGA GGGCCCTGAA TGCCACCCTC CAGTGAAAGT TATTCAGAGT 
CAAGATGGCT TCCCAGCTGG CCAAGAACTC CTTGGATACA AAGCACTGGA CCCGGAAATA 
TCCAGTGGTG AAGGCTTAAG GTATCAGAAG TTAGGGGATG AAGATAACTG GTTTGAAATT 
AATCAACACA CTGGCGACTT GAGAACTCTA AAAGTACTAG ATAGAGAATC CAAATTTGTA 
AAAAACAACC AATACAATAT TTCAGTTGTT GCAGTGGATG CAGTTGGCCG ATCTTGCACT 
GGAACATTAG TAGTTCATTT GGATGATTAC AACGATCACG CACCTCAAAT TGACAAAGAA 
GTGACCATTT GTCAGAATAA TGAGGATTTT GCTGTTCTGA AACCTGTAGA TCCAGATGGA 
CCTGAAAATG GACCACCTTT TCAATTCTTT CTGGATAATT CTGCCAGTAA AAACTGGAAC 
ATAGAAGAAA AGGATGGTAA AACTGCCATT CTTCGTCAAC GGCAAAATCT TGATTATAAC 
TATTATTCTG TGCCTATTCA AATAAAAGAC AGGCATGGTT TAGTTGCAAC ACATATGTTA 
ACAGTGAGAG TATGTGACTG TTCAACTCCA TCTGAGTGTA GAATGAAGGA TAAAAGTACA 
AGAGACGTTA GACCAAATGT AATACTTGGA AGATGGGCTA TTCTTGCTAT GGTGTTGGGT 
TCTGTATTGT TATTATGTAT TCTGTTTACA TGTTTCTGTG TCACTGCTAA GAGAACAGTC 
AAGAAATGTT TTCCAGAAGA CATAGCCCAG CAAAATTTAA TTGTATCAAA TACTGAAGGA 
CCTGGAGAAG AAGTAACGGA AGCAAATATT AGACTCCCCA TGCAGACATC CAACATTTGT 
GACACAAGCA TGTCTGTTGG TACTGTTGGT GGCCAGGGAA TCAAAACACA GCAAAGTTTT 
GAGATGGTCA AAGGAGGCTA CACTTTGGAT TCCAACAAAG GAGGTGGACA TCAGACCTTG 
GAGTCCGTCA AGGGAGTGGG GCAGGGAGAT ACTGGCAGAT ATGCGTACAC GGACTGGCAG 
AGTTTCACCC AACCTCGGCT TGGCGAAGAA TCCATTAGAG GACACACTCT GATTAAAAAT 
TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DSC1 ( NM_024421.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_077739.1 Homo sapiens desmocollin 1 (DSC1), transcript variant Dsc1a, mRNA.

Price & Availability↑

CloneID	OHu25076
Clone ID Related Accession (Same CDS sequence)	NM_024421.2
Accession Version	NM_024421.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2685bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-03
Organism	Homo sapiens(human)
Product	desmocollin-1 isoform Dsc1a preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from X72925.1, Z34522.1, AC012417.13, CU447407.1 and CU444724.1. On Sep 19, 2008 this sequence version replaced NM_024421.1. Transcript Variant: This variant (Dsc1a) represents the shorter transcript and encodes the longer isoform (Dsc1a). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## inferred exon combination :: based on alignments, homology RefSeq Select criteria :: based on conservation, longest protein ##RefSeq-Attributes-END##

ATGGCTCTGG CCTCTGCTGC CCCAGGGAGC ATCTTCTGTA AGCAGCTCCT TTTCTCTCTC 
CTGGTTTTAA CATTACTTTG CGATGCTTGT CAGAAAGTTT ATCTTCGAGT TCCTTCTCAT 
CTTCAGGCTG AAACACTTGT AGGCAAAGTG AATCTGGAGG AGTGTCTCAA GTCGGCCAGC 
CTAATCCGGT CCAGTGACCC TGCCTTCAGA ATTCTAGAAG ATGGCTCAAT TTACACAACA 
CATGACCTCA TTTTGTCTTC TGAAAGGAAA AGTTTTTCCA TTTTCCTTTC AGATGGTCAG 
AGACGGGAAC AACAAGAGAT AAAAGTTGTA CTGTCAGCAA GAGAAAACAA GTCTCCTAAG 
AAGAGACATA CCAAAGACAC AGCCCTCAAG CGCAGCAAGA GACGATGGGC TCCTATTCCA 
GCTTCATTGA TGGAGAACTC GTTGGGTCCA TTTCCACAAC ACGTTCAGCA GATCCAATCT 
GATGCTGCAC AGAATTACAC CATCTTTTAT TCCATAAGTG GGCCAGGCGT GGACAAAGAA 
CCCTTCAATT TGTTTTACAT AGAGAAAGAC ACTGGGGATA TCTTTTGTAC AAGGAGCATT 
GACCGTGAGA AATATGAACA GTTTGCGTTA TATGGCTATG CAACAACTGC AGATGGCTAT 
GCACCAGAAT ATCCACTCCC TTTGATCATC AAAATTGAAG ATGATAATGA TAACGCCCCA 
TATTTTGAAC ACAGAGTGAC TATCTTTACT GTGCCTGAAA ATTGCCGATC CGGAACTTCA 
GTGGGAAAAG TGACCGCCAC AGACCTTGAC GAACCTGACA CTCTCCATAC TCGTCTGAAA 
TATAAAATCT TACAACAAAT CCCAGATCAT CCAAAGCATT TCTCCATACA CCCAGATACC 
GGTGTCATCA CCACAACTAC ACCTTTTCTG GATAGAGAAA AATGTGATAC TTACCAGTTA 
ATAATGGAAG TGCGAGACAT GGGTGGTCAG CCTTTCGGTT TATTTAATAC AGGAACAATT 
ACTATTTCAC TTGAGGATGA AAATGACAAT CCACCATCTT TCACAGAAAC TTCTTATGTT 
ACAGAAGTAG AAGAAAACAG AATTGACGTG GAGATTTTAC GAATGAAGGT ACAGGATCAG 
GATTTGCCAA ACACTCCTCA CTCAAAGGCT GTATACAAAA TCCTACAAGG AAATGAAAAT 
GGAAACTTCA TAATTAGCAC AGATCCAAAT ACAAATGAAG GAGTGCTGTG TGTTGTCAAG 
CCATTGAACT ATGAAGTCAA TCGCCAAGTT ATTTTGCAAG TTGGTGTCAT TAACGAGGCA 
CAATTCTCTA AAGCAGCGAG CTCACAAACT CCTACAATGT GCACTACAAC TGTCACCGTT 
AAAATTATAG ACAGTGATGA GGGCCCTGAA TGCCACCCTC CAGTGAAAGT TATTCAGAGT 
CAAGATGGCT TCCCAGCTGG CCAAGAACTC CTTGGATACA AAGCACTGGA CCCGGAAATA 
TCCAGTGGTG AAGGCTTAAG GTATCAGAAG TTAGGGGATG AAGATAACTG GTTTGAAATT 
AATCAACACA CTGGCGACTT GAGAACTCTA AAAGTACTAG ATAGAGAATC CAAATTTGTA 
AAAAACAACC AATACAATAT TTCAGTTGTT GCAGTGGATG CAGTTGGCCG ATCTTGCACT 
GGAACATTAG TAGTTCATTT GGATGATTAC AACGATCACG CACCTCAAAT TGACAAAGAA 
GTGACCATTT GTCAGAATAA TGAGGATTTT GCTGTTCTGA AACCTGTAGA TCCAGATGGA 
CCTGAAAATG GACCACCTTT TCAATTCTTT CTGGATAATT CTGCCAGTAA AAACTGGAAC 
ATAGAAGAAA AGGATGGTAA AACTGCCATT CTTCGTCAAC GGCAAAATCT TGATTATAAC 
TATTATTCTG TGCCTATTCA AATAAAAGAC AGGCATGGTT TAGTTGCAAC ACATATGTTA 
ACAGTGAGAG TATGTGACTG TTCAACTCCA TCTGAGTGTA GAATGAAGGA TAAAAGTACA 
AGAGACGTTA GACCAAATGT AATACTTGGA AGATGGGCTA TTCTTGCTAT GGTGTTGGGT 
TCTGTATTGT TATTATGTAT TCTGTTTACA TGTTTCTGTG TCACTGCTAA GAGAACAGTC 
AAGAAATGTT TTCCAGAAGA CATAGCCCAG CAAAATTTAA TTGTATCAAA TACTGAAGGA 
CCTGGAGAAG AAGTAACGGA AGCAAATATT AGACTCCCCA TGCAGACATC CAACATTTGT 
GACACAAGCA TGTCTGTTGG TACTGTTGGT GGCCAGGGAA TCAAAACACA GCAAAGTTTT 
GAGATGGTCA AAGGAGGCTA CACTTTGGAT TCCAACAAAG GAGGTGGACA TCAGACCTTG 
GAGTCCGTCA AGGGAGTGGG GCAGGGAGAT ACTGGCAGAT ATGCGTACAC GGACTGGCAG 
AGTTTCACCC AACCTCGGCT TGGCGAAAAG GTGTATTTGT GTGGACAAGA TGAGGAGCAT 
AAACATTGTG AAGACTACGT TTGTTCGTAT AACTATGAAG GCAAAGGTTC TCTGGCCGGC 
TCAGTAGGTT GCTGCAGCGA TCGGCAGGAA GAAGAGGGAC TGGAGTTTCT AGATCACCTG 
GAACCCAAAT TTAGGACATT AGCAAAGACA TGCATCAAGA AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_077739.1
CDS	263..2947
Translation	MALASAAPGSIFCKQLLFSLLVLTLLCDACQKVYLRVPSHLQAETLVGKVNLEECLKSASLIRSSDPAFRILEDGSIYTTHDLILSSERKSFSIFLSDGQRREQQEIKVVLSARENKSPKKRHTKDTALKRSKRRWAPIPASLMENSLGPFPQHVQQIQSDAAQNYTIFYSISGPGVDKEPFNLFYIEKDTGDIFCTRSIDREKYEQFALYGYATTADGYAPEYPLPLIIKIEDDNDNAPYFEHRVTIFTVPENCRSGTSVGKVTATDLDEPDTLHTRLKYKILQQIPDHPKHFSIHPDTGVITTTTPFLDREKCDTYQLIMEVRDMGGQPFGLFNTGTITISLEDENDNPPSFTETSYVTEVEENRIDVEILRMKVQDQDLPNTPHSKAVYKILQGNENGNFIISTDPNTNEGVLCVVKPLNYEVNRQVILQVGVINEAQFSKAASSQTPTMCTTTVTVKIIDSDEGPECHPPVKVIQSQDGFPAGQELLGYKALDPEISSGEGLRYQKLGDEDNWFEINQHTGDLRTLKVLDRESKFVKNNQYNISVVAVDAVGRSCTGTLVVHLDDYNDHAPQIDKEVTICQNNEDFAVLKPVDPDGPENGPPFQFFLDNSASKNWNIEEKDGKTAILRQRQNLDYNYYSVPIQIKDRHGLVATHMLTVRVCDCSTPSECRMKDKSTRDVRPNVILGRWAILAMVLGSVLLLCILFTCFCVTAKRTVKKCFPEDIAQQNLIVSNTEGPGEEVTEANIRLPMQTSNICDTSMSVGTVGGQGIKTQQSFEMVKGGYTLDSNKGGGHQTLESVKGVGQGDTGRYAYTDWQSFTQPRLGEKVYLCGQDEEHKHCEDYVCSYNYEGKGSLAGSVGCCSDRQEEEGLEFLDHLEPKFRTLAKTCIKK

Target ORF information:

RefSeq Version	NM_024421.2
Organism	Homo sapiens(human)
Definition	Homo sapiens desmocollin 1 (DSC1), transcript variant Dsc1a, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_024421.2

ORF Insert Sequence:

ATGGCTCTGG CCTCTGCTGC CCCAGGGAGC ATCTTCTGTA AGCAGCTCCT TTTCTCTCTC 
CTGGTTTTAA CATTACTTTG CGATGCTTGT CAGAAAGTTT ATCTTCGAGT TCCTTCTCAT 
CTTCAGGCTG AAACACTTGT AGGCAAAGTG AATCTGGAGG AGTGTCTCAA GTCGGCCAGC 
CTAATCCGGT CCAGTGACCC TGCCTTCAGA ATTCTAGAAG ATGGCTCAAT TTACACAACA 
CATGACCTCA TTTTGTCTTC TGAAAGGAAA AGTTTTTCCA TTTTCCTTTC AGATGGTCAG 
AGACGGGAAC AACAAGAGAT AAAAGTTGTA CTGTCAGCAA GAGAAAACAA GTCTCCTAAG 
AAGAGACATA CCAAAGACAC AGCCCTCAAG CGCAGCAAGA GACGATGGGC TCCTATTCCA 
GCTTCATTGA TGGAGAACTC GTTGGGTCCA TTTCCACAAC ACGTTCAGCA GATCCAATCT 
GATGCTGCAC AGAATTACAC CATCTTTTAT TCCATAAGTG GGCCAGGCGT GGACAAAGAA 
CCCTTCAATT TGTTTTACAT AGAGAAAGAC ACTGGGGATA TCTTTTGTAC AAGGAGCATT 
GACCGTGAGA AATATGAACA GTTTGCGTTA TATGGCTATG CAACAACTGC AGATGGCTAT 
GCACCAGAAT ATCCACTCCC TTTGATCATC AAAATTGAAG ATGATAATGA TAACGCCCCA 
TATTTTGAAC ACAGAGTGAC TATCTTTACT GTGCCTGAAA ATTGCCGATC CGGAACTTCA 
GTGGGAAAAG TGACCGCCAC AGACCTTGAC GAACCTGACA CTCTCCATAC TCGTCTGAAA 
TATAAAATCT TACAACAAAT CCCAGATCAT CCAAAGCATT TCTCCATACA CCCAGATACC 
GGTGTCATCA CCACAACTAC ACCTTTTCTG GATAGAGAAA AATGTGATAC TTACCAGTTA 
ATAATGGAAG TGCGAGACAT GGGTGGTCAG CCTTTCGGTT TATTTAATAC AGGAACAATT 
ACTATTTCAC TTGAGGATGA AAATGACAAT CCACCATCTT TCACAGAAAC TTCTTATGTT 
ACAGAAGTAG AAGAAAACAG AATTGACGTG GAGATTTTAC GAATGAAGGT ACAGGATCAG 
GATTTGCCAA ACACTCCTCA CTCAAAGGCT GTATACAAAA TCCTACAAGG AAATGAAAAT 
GGAAACTTCA TAATTAGCAC AGATCCAAAT ACAAATGAAG GAGTGCTGTG TGTTGTCAAG 
CCATTGAACT ATGAAGTCAA TCGCCAAGTT ATTTTGCAAG TTGGTGTCAT TAACGAGGCA 
CAATTCTCTA AAGCAGCGAG CTCACAAACT CCTACAATGT GCACTACAAC TGTCACCGTT 
AAAATTATAG ACAGTGATGA GGGCCCTGAA TGCCACCCTC CAGTGAAAGT TATTCAGAGT 
CAAGATGGCT TCCCAGCTGG CCAAGAACTC CTTGGATACA AAGCACTGGA CCCGGAAATA 
TCCAGTGGTG AAGGCTTAAG GTATCAGAAG TTAGGGGATG AAGATAACTG GTTTGAAATT 
AATCAACACA CTGGCGACTT GAGAACTCTA AAAGTACTAG ATAGAGAATC CAAATTTGTA 
AAAAACAACC AATACAATAT TTCAGTTGTT GCAGTGGATG CAGTTGGCCG ATCTTGCACT 
GGAACATTAG TAGTTCATTT GGATGATTAC AACGATCACG CACCTCAAAT TGACAAAGAA 
GTGACCATTT GTCAGAATAA TGAGGATTTT GCTGTTCTGA AACCTGTAGA TCCAGATGGA 
CCTGAAAATG GACCACCTTT TCAATTCTTT CTGGATAATT CTGCCAGTAA AAACTGGAAC 
ATAGAAGAAA AGGATGGTAA AACTGCCATT CTTCGTCAAC GGCAAAATCT TGATTATAAC 
TATTATTCTG TGCCTATTCA AATAAAAGAC AGGCATGGTT TAGTTGCAAC ACATATGTTA 
ACAGTGAGAG TATGTGACTG TTCAACTCCA TCTGAGTGTA GAATGAAGGA TAAAAGTACA 
AGAGACGTTA GACCAAATGT AATACTTGGA AGATGGGCTA TTCTTGCTAT GGTGTTGGGT 
TCTGTATTGT TATTATGTAT TCTGTTTACA TGTTTCTGTG TCACTGCTAA GAGAACAGTC 
AAGAAATGTT TTCCAGAAGA CATAGCCCAG CAAAATTTAA TTGTATCAAA TACTGAAGGA 
CCTGGAGAAG AAGTAACGGA AGCAAATATT AGACTCCCCA TGCAGACATC CAACATTTGT 
GACACAAGCA TGTCTGTTGG TACTGTTGGT GGCCAGGGAA TCAAAACACA GCAAAGTTTT 
GAGATGGTCA AAGGAGGCTA CACTTTGGAT TCCAACAAAG GAGGTGGACA TCAGACCTTG 
GAGTCCGTCA AGGGAGTGGG GCAGGGAGAT ACTGGCAGAT ATGCGTACAC GGACTGGCAG 
AGTTTCACCC AACCTCGGCT TGGCGAAAAG GTGTATTTGT GTGGACAAGA TGAGGAGCAT 
AAACATTGTG AAGACTACGT TTGTTCGTAT AACTATGAAG GCAAAGGTTC TCTGGCCGGC 
TCAGTAGGTT GCTGCAGCGA TCGGCAGGAA GAAGAGGGAC TGGAGTTTCT AGATCACCTG 
GAACCCAAAT TTAGGACATT AGCAAAGACA TGCATCAAGA AATAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human gingiva transcriptome during wound healing.
Journal of clinical periodontology44(4)394-402(2017 Apr)
Wang Y,Tatakis DN

Lower DSC1 expression is related to the poor differentiation and prognosis of head and neck squamous cell carcinoma (HNSCC).
Journal of cancer research and clinical oncology142(12)2461-2468(2016 Dec)
Wang Y,Chen C,Wang X,Jin F,Liu Y,Liu H,Li T,Fu J

Expression of desmosomal proteins in acantholytic squamous cell carcinoma of the skin.
Histology and histopathology30(8)945-53(2015 Aug)
Jur?i? V,Kukovi? J,Zidar N

Pemphigus herpetiformis with IgG autoantibodies to desmoglein 1 and desmocollin 1.
The British journal of dermatology172(4)1144-6(2015 Apr)
On HR,Hashimoto T,Kim SC

Transcriptional regulation of genes involved in keratinocyte differentiation by human papillomavirus 16 oncoproteins.
Archives of virology160(2)389-98(2015 Feb)
Gy?ngy?si E,Szalm?s A,Ferenczi A,P?liska S,K?nya J,Veress G

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DSC1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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