Gene Symbol | DRD4 |
Entrez Gene ID | 1815 |
Full Name | dopamine receptor D4 |
Synonyms | D4DR |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats; the sequence shown contains four repeats. [provided by RefSeq, Jul 2008]. |
Disorder MIM: | |
Disorder Html: | Autonomic nervous system dysfunction (3); [Novelty seeking personality], 601696 (1); {Attention deficit-hyperactivity disorder}, 143465 (3) |