DR1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DR1
Entrez Gene ID	1810
Full Name	down-regulator of transcription 1
Synonyms	NC2,NC2-BETA,NC2B,NCB2
General protein information	Preferred Names down-regulator of transcription 1 Names protein Dr1 TATA-binding protein-associated phosphoprotein negative cofactor 2 negative cofactor 2-beta
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p22.1
Summary	This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008].
Disorder MIM:	601482

mRNA and Protein(s)

mRNA	Protein	Name
NM_001938.2	NP_001929.1	protein Dr1
NM_001938.3	NP_001929.1	protein Dr1

Pathways from BioSystems

Homologies

Homo sapiens (human)	DR1	NP_001929.1
Saccharomyces cerevisiae (baker's yeast)	NCB2	NP_010685.1
Kluyveromyces lactis	KLLA0C06611g	XP_452492.1
Magnaporthe oryzae (rice blast fungus)	MGG_02824	XP_003720914.1
Oryza sativa (rice)	Os08g0383700	NP_001061698.1
Rattus norvegicus (Norway rat)	Dr1	NP_001011914.1
Gallus gallus (chicken)	DR1	NP_001008478.1
Danio rerio (zebrafish)	LOC100536903	XP_005168804.1
Danio rerio (zebrafish)	dr1	NP_001070782.1
Arabidopsis thaliana (thale cress)	NF-YB13	NP_851060.1
Rattus norvegicus (Norway rat)	LOC100910207	XP_003751365.1
Anopheles gambiae (African malaria mosquito)	AgaP_AGAP010322	XP_318244.2
Arabidopsis thaliana (thale cress)	NF-YB12	NP_001078545.1
Xenopus tropicalis (tropical clawed frog)	dr1	NP_001039251.1
Canis lupus familiaris (dog)	DR1	XP_537068.1
Bos taurus (cattle)	DR1	NP_001039984.1
Mus musculus (house mouse)	Dr1	NP_080382.2
Eremothecium gossypii	AGOS_AFR397C	NP_985944.1
Neurospora crassa	NCU02017	XP_964882.2
Pan troglodytes (chimpanzee)	DR1	XP_001154876.1
	DR1	XP_001102017.1
Drosophila melanogaster (fruit fly)	NC2beta	NP_609736.1
Caenorhabditis elegans (roundworm)	dro-1	NP_499750.1
Schizosaccharomyces pombe (fission yeast)	SPBC30D10.02	NP_596283.1

Gene Ontology
Bibliography

Related articles in PubMed

The effect and mechanism of dopamine D1 receptors on the proliferation of osteosarcoma cells.
Gao J, Zhang C, Gao F, Li H
Molecular and cellular biochemistry430(1-2)31-36(2017 Jun)

An inter-species protein-protein interaction network across vast evolutionary distance.
Zhong Q, Pevzner SJ, Hao T, Wang Y, Mosca R, Menche J, Taipale M, Ta?an M, Fan C, Yang X, Haley P, Murray RR, Mer F, Gebreab F, Tam S, MacWilliams A, Dricot A, Reichert P, Santhanam B, Ghamsari L, Calderwood MA, Rolland T, Charloteaux B, Lindquist S, Barab?si AL, Hill DE, Aloy P, Cusick ME, Xia Y, Roth FP, Vidal M
Molecular systems biology12(4)865(2016 Apr)

A host susceptibility gene, DR1, facilitates influenza A virus replication by suppressing host innate immunity and enhancing viral RNA replication.
Hsu SF, Su WC, Jeng KS, Lai MM
Journal of virology89(7)3671-82(2015 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

results suggest that DR1 are expressed in the osteosarcoma cells and inhibit the proliferation of osteosarcoma cells by the down-regulation of the ERK1/2 and PI3K-Akt pathways.
Title: The effect and mechanism of dopamine D1 receptors on the proliferation of osteosarcoma cells.

Knockdown of DR1 resulted in reductions of viral RNA and protein production, demonstrating that DR1 acts as a positive host factor in influenza A virus replication.
Title: A host susceptibility gene, DR1, facilitates influenza A virus replication by suppressing host innate immunity and enhancing viral RNA replication.

Observational study of gene-disease association. (HuGE Navigator)
Title: Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals.

The physiological functions of human Dr1 include regulation of polymerase III transcription.
Title: Dr1 (NC2) is present at tRNA genes and represses their transcription in human cells.

Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells.
Title: Basal core promoters control the equilibrium between negative cofactor 2 and preinitiation complexes in human cells.

The following DR1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DR1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu29745	NM_001938.3 Latest version!	Homo sapiens down-regulator of transcription 1 (DR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu29745	NM_001938.2	Homo sapiens down-regulator of transcription 1 (DR1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DR1 ( NM_001938.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001929.1 Homo sapiens down-regulator of transcription 1 (DR1), mRNA.

Price & Availability↑

CloneID	OHu29745
Clone ID Related Accession (Same CDS sequence)	NM_001938.2 , NM_001938.3
Accession Version	NM_001938.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-28
Organism	Homo sapiens(human)
Product	protein Dr1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC035507.2 and AL833729.1. On Mar 4, 2004 this sequence version replaced NM_001938.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035507.2, AL833729.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGCTTCCT CGTCTGGCAA CGATGATGAT CTCACTATCC CCAGAGCTGC TATCAATAAA 
ATGATCAAAG AGACTCTTCC TAATGTCCGG GTGGCCAACG ATGCTCGAGA GCTGGTGGTG 
AACTGCTGCA CTGAATTCAT TCACCTTATA TCTTCTGAAG CCAATGAGAT TTGTAACAAA 
TCGGAAAAGA AGACCATCTC ACCAGAGCAT GTCATACAAG CACTAGAAAG TTTGGGATTT 
GGCTCTTACA TCAGTGAAGT AAAAGAAGTC TTGCAAGAGT GTAAAACAGT AGCATTAAAA 
AGAAGAAAGG CCAGTTCTCG TTTGGAAAAC CTTGGCATTC CTGAAGAAGA GTTATTGAGA 
CAGCAACAAG AATTATTTGC AAAAGCTAGA CAGCAACAAG CAGAATTGGC CCAACAGGAA 
TGGCTTCAAA TGCAGCAAGC TGCCCAACAA GCCCAGCTTG CTGCTGCCTC AGCCAGTGCA 
TCTAATCAGG CGGGATCTTC TCAGGATGAA GAAGATGATG ATGATATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001929.1
CDS	726..1256
Translation	MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI

Target ORF information:

RefSeq Version	NM_001938.2
Organism	Homo sapiens(human)
Definition	Homo sapiens down-regulator of transcription 1 (DR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001938.2

ORF Insert Sequence:

ATGGCTTCCT CGTCTGGCAA CGATGATGAT CTCACTATCC CCAGAGCTGC TATCAATAAA 
ATGATCAAAG AGACTCTTCC TAATGTCCGG GTGGCCAACG ATGCTCGAGA GCTGGTGGTG 
AACTGCTGCA CTGAATTCAT TCACCTTATA TCTTCTGAAG CCAATGAGAT TTGTAACAAA 
TCGGAAAAGA AGACCATCTC ACCAGAGCAT GTCATACAAG CACTAGAAAG TTTGGGATTT 
GGCTCTTACA TCAGTGAAGT AAAAGAAGTC TTGCAAGAGT GTAAAACAGT AGCATTAAAA 
AGAAGAAAGG CCAGTTCTCG TTTGGAAAAC CTTGGCATTC CTGAAGAAGA GTTATTGAGA 
CAGCAACAAG AATTATTTGC AAAAGCTAGA CAGCAACAAG CAGAATTGGC CCAACAGGAA 
TGGCTTCAAA TGCAGCAAGC TGCCCAACAA GCCCAGCTTG CTGCTGCCTC AGCCAGTGCA 
TCTAATCAGG CGGGATCTTC TCAGGATGAA GAAGATGATG ATGATATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DR1 ( NM_001938.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001929.1 Homo sapiens down-regulator of transcription 1 (DR1), mRNA.

Price & Availability↑

CloneID	OHu29745
Clone ID Related Accession (Same CDS sequence)	NM_001938.2 , NM_001938.3
Accession Version	NM_001938.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 531bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-13
Organism	Homo sapiens(human)
Product	protein Dr1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL137159.7, BC035507.2 and AL833729.1. On Nov 23, 2018 this sequence version replaced NM_001938.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.16018.1, SRR3476690.1028365.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000370272.9/ ENSP00000359295.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCTTCCT CGTCTGGCAA CGATGATGAT CTCACTATCC CCAGAGCTGC TATCAATAAA 
ATGATCAAAG AGACTCTTCC TAATGTCCGG GTGGCCAACG ATGCTCGAGA GCTGGTGGTG 
AACTGCTGCA CTGAATTCAT TCACCTTATA TCTTCTGAAG CCAATGAGAT TTGTAACAAA 
TCGGAAAAGA AGACCATCTC ACCAGAGCAT GTCATACAAG CACTAGAAAG TTTGGGATTT 
GGCTCTTACA TCAGTGAAGT AAAAGAAGTC TTGCAAGAGT GTAAAACAGT AGCATTAAAA 
AGAAGAAAGG CCAGTTCTCG TTTGGAAAAC CTTGGCATTC CTGAAGAAGA GTTATTGAGA 
CAGCAACAAG AATTATTTGC AAAAGCTAGA CAGCAACAAG CAGAATTGGC CCAACAGGAA 
TGGCTTCAAA TGCAGCAAGC TGCCCAACAA GCCCAGCTTG CTGCTGCCTC AGCCAGTGCA 
TCTAATCAGG CGGGATCTTC TCAGGATGAA GAAGATGATG ATGATATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001929.1
CDS	740..1270
Translation	MASSSGNDDDLTIPRAAINKMIKETLPNVRVANDARELVVNCCTEFIHLISSEANEICNKSEKKTISPEHVIQALESLGFGSYISEVKEVLQECKTVALKRRKASSRLENLGIPEEELLRQQQELFAKARQQQAELAQQEWLQMQQAAQQAQLAAASASASNQAGSSQDEEDDDDI

Target ORF information:

RefSeq Version	NM_001938.3
Organism	Homo sapiens(human)
Definition	Homo sapiens down-regulator of transcription 1 (DR1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001938.3

ORF Insert Sequence:

ATGGCTTCCT CGTCTGGCAA CGATGATGAT CTCACTATCC CCAGAGCTGC TATCAATAAA 
ATGATCAAAG AGACTCTTCC TAATGTCCGG GTGGCCAACG ATGCTCGAGA GCTGGTGGTG 
AACTGCTGCA CTGAATTCAT TCACCTTATA TCTTCTGAAG CCAATGAGAT TTGTAACAAA 
TCGGAAAAGA AGACCATCTC ACCAGAGCAT GTCATACAAG CACTAGAAAG TTTGGGATTT 
GGCTCTTACA TCAGTGAAGT AAAAGAAGTC TTGCAAGAGT GTAAAACAGT AGCATTAAAA 
AGAAGAAAGG CCAGTTCTCG TTTGGAAAAC CTTGGCATTC CTGAAGAAGA GTTATTGAGA 
CAGCAACAAG AATTATTTGC AAAAGCTAGA CAGCAACAAG CAGAATTGGC CCAACAGGAA 
TGGCTTCAAA TGCAGCAAGC TGCCCAACAA GCCCAGCTTG CTGCTGCCTC AGCCAGTGCA 
TCTAATCAGG CGGGATCTTC TCAGGATGAA GAAGATGATG ATGATATCTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The effect and mechanism of dopamine D1 receptors on the proliferation of osteosarcoma cells.
Molecular and cellular biochemistry430(1-2)31-36(2017 Jun)
Gao J,Zhang C,Gao F,Li H

An inter-species protein-protein interaction network across vast evolutionary distance.
Molecular systems biology12(4)865(2016 Apr)
Zhong Q,Pevzner SJ,Hao T,Wang Y,Mosca R,Menche J,Taipale M,Ta?an M,Fan C,Yang X,Haley P,Murray RR,Mer F,Gebreab F,Tam S,MacWilliams A,Dricot A,Reichert P,Santhanam B,Ghamsari L,Calderwood MA,Rolland T,Charloteaux B,Lindquist S,Barab?si AL,Hill DE,Aloy P,Cusick ME,Xia Y,Roth FP,Vidal M

A host susceptibility gene, DR1, facilitates influenza A virus replication by suppressing host innate immunity and enhancing viral RNA replication.
Journal of virology89(7)3671-82(2015 Apr)
Hsu SF,Su WC,Jeng KS,Lai MM

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DR1 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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