DPT cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DPT
Entrez Gene ID	1805
Full Name	dermatopontin
Synonyms	TRAMP
General protein information	Preferred Names dermatopontin Names dermatopontin tyrosine-rich acidic matrix protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1q24.2
Summary	Dermatopontin is an extracellular matrix protein with possible functions in cell-matrix interactions and matrix assembly. The protein is found in various tissues and many of its tyrosine residues are sulphated. Dermatopontin is postulated to modify the behavior of TGF-beta through interaction with decorin. [provided by RefSeq, Jul 2008].
Disorder MIM:	125597

mRNA and Protein(s)

mRNA	Protein	Name
NM_001937.5	NP_001928.2	dermatopontin precursor
NM_001937.4	NP_001928.2	dermatopontin precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	DPT	NP_001039368.1
Homo sapiens (human)	DPT	NP_001928.2
Pan troglodytes (chimpanzee)	DPT	XP_001135049.1
Gallus gallus (chicken)	DPT	XP_001231676.2
Canis lupus familiaris (dog)	DPT	XP_547476.1
Xenopus tropicalis (tropical clawed frog)	dpt	NP_001025599.1
Danio rerio (zebrafish)	si:dkey-98p3.2	NP_001025256.2
Mus musculus (house mouse)	Dpt	NP_062733.1

Gene Ontology
Bibliography

Related articles in PubMed

Effects of Dermatopontin gene silencing on apoptosis and proliferation of osteosarcoma MG?63 cells.
Xi LC, Ji YX, Yin D, Zhao ZX, Huang SC, Yu SL, Liu BY, Li HY
Molecular medicine reports17(1)422-427(2018 Jan)

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR, Hynes RO
Journal of proteome research16(8)3083-3091(2017 Aug)

Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere's disease.
Mart?n-Sierra C, Gallego-Martinez A, Requena T, Frejo L, Batuecas-Caletr?o A, Lopez-Escamez JA
European journal of human genetics : EJHG25(2)200-207(2017 02)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Novel mutation in DPT segregates with the complete phenotype with variable expressivity in two pedigrees with autosomal dominant familial Meniere's disease.
Title: Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere's disease.

Lumican, decorin and dermatopontin are differentially expressed and may serve as biomarkers for metastatic and recurrent Giant cell tumor of bone
Title: Gene expression profiling of giant cell tumor of bone reveals downregulation of extracellular matrix components decorin and lumican associated with lung metastasis.

This study essentially deals with assessing the expression and integrity of an extracellular matrix protein, Dermatopontin (DPT), in chronic cutaneous wounds.
Title: Expression and integrity of dermatopontin in chronic cutaneous wounds: a crucial factor in impaired wound healing.

dermatopontin functional peptide produces fibrinogen fibrils and modifies its biological activity
Title: Functional peptide of dermatopontin produces fibrinogen fibrils and modifies its biological activity.

The obtained results indicate that the changes in gene expression in bone marrow progenitor cells can be involved into space flight-induced osteopenia.
Title: [The effects of simulated microgravity on the pattern of gene expression in human bone marrow mesenchymal stem cells under osteogenic differentiation].

The following DPT gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DPT cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09750	NM_001937.5 Latest version!	Homo sapiens dermatopontin (DPT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09750	NM_001937.4	Homo sapiens dermatopontin (DPT), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DPT ( NM_001937.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001928.2 Homo sapiens dermatopontin (DPT), mRNA.

Price & Availability↑

CloneID	OHu09750
Clone ID Related Accession (Same CDS sequence)	NM_001937.5 , NM_001937.4
Accession Version	NM_001937.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-10-23
Organism	Homo sapiens(human)
Product	dermatopontin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AL049798.7, BP257325.1 and BC033736.1. On Nov 23, 2018 this sequence version replaced NM_001937.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR5189655.76823.1, SRR5189667.139882.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000367817.4/ ENSP00000356791.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGACCTCA GTCTTCTCTG GGTACTTCTG CCCCTAGTCA CCATGGCCTG GGGCCAGTAT 
GGCGATTATG GATACCCATA CCAGCAGTAT CATGACTACA GCGATGATGG GTGGGTGAAT 
TTGAACCGGC AAGGCTTCAG CTACCAGTGT CCCCAGGGGC AGGTGATAGT GGCCGTGAGG 
AGCATCTTCA GCAAGAAGGA AGGTTCTGAC AGACAATGGA ACTACGCCTG CATGCCCACG 
CCACAGAGCC TCGGGGAACC CACGGAGTGC TGGTGGGAGG AGATCAACAG GGCTGGCATG 
GAATGGTACC AGACGTGCTC CAACAATGGG CTGGTGGCAG GATTCCAGAG CCGCTACTTC 
GAGTCAGTGC TGGATCGGGA GTGGCAGTTT TACTGTTGTC GCTACAGCAA GAGGTGCCCA 
TATTCCTGCT GGCTAACAAC AGAATATCCA GGTCACTATG GTGAGGAAAT GGACATGATT 
TCCTACAATT ATGATTACTA TATCCGAGGA GCAACAACCA CTTTCTCTGC AGTGGAAAGG 
GATCGCCAGT GGAAGTTCAT AATGTGCCGG ATGACTGAAT ACGACTGTGA ATTTGCAAAT 
GTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001928.2
CDS	33..638
Translation	MDLSLLWVLLPLVTMAWGQYGDYGYPYQQYHDYSDDGWVNLNRQGFSYQCPQGQVIVAVRSIFSKKEGSDRQWNYACMPTPQSLGEPTECWWEEINRAGMEWYQTCSNNGLVAGFQSRYFESVLDREWQFYCCRYSKRCPYSCWLTTEYPGHYGEEMDMISYNYDYYIRGATTTFSAVERDRQWKFIMCRMTEYDCEFANV

Target ORF information:

RefSeq Version	NM_001937.5
Organism	Homo sapiens(human)
Definition	Homo sapiens dermatopontin (DPT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001937.5

ORF Insert Sequence:

ATGGACCTCA GTCTTCTCTG GGTACTTCTG CCCCTAGTCA CCATGGCCTG GGGCCAGTAT 
GGCGATTATG GATACCCATA CCAGCAGTAT CATGACTACA GCGATGATGG GTGGGTGAAT 
TTGAACCGGC AAGGCTTCAG CTACCAGTGT CCCCAGGGGC AGGTGATAGT GGCCGTGAGG 
AGCATCTTCA GCAAGAAGGA AGGTTCTGAC AGACAATGGA ACTACGCCTG CATGCCCACG 
CCACAGAGCC TCGGGGAACC CACGGAGTGC TGGTGGGAGG AGATCAACAG GGCTGGCATG 
GAATGGTACC AGACGTGCTC CAACAATGGG CTGGTGGCAG GATTCCAGAG CCGCTACTTC 
GAGTCAGTGC TGGATCGGGA GTGGCAGTTT TACTGTTGTC GCTACAGCAA GAGGTGCCCA 
TATTCCTGCT GGCTAACAAC AGAATATCCA GGTCACTATG GTGAGGAAAT GGACATGATT 
TCCTACAATT ATGATTACTA TATCCGAGGA GCAACAACCA CTTTCTCTGC AGTGGAAAGG 
GATCGCCAGT GGAAGTTCAT AATGTGCCGG ATGACTGAAT ACGACTGTGA ATTTGCAAAT 
GTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DPT ( NM_001937.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001928.2 Homo sapiens dermatopontin (DPT), mRNA.

Price & Availability↑

CloneID	OHu09750
Clone ID Related Accession (Same CDS sequence)	NM_001937.5 , NM_001937.4
Accession Version	NM_001937.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 606bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	dermatopontin precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BP257325.1, BC033736.1 and AI699890.1. On Jun 26, 2010 this sequence version replaced NM_001937.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC033736.1, ERR279853.67.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGACCTCA GTCTTCTCTG GGTACTTCTG CCCCTAGTCA CCATGGCCTG GGGCCAGTAT 
GGCGATTATG GATACCCATA CCAGCAGTAT CATGACTACA GCGATGATGG GTGGGTGAAT 
TTGAACCGGC AAGGCTTCAG CTACCAGTGT CCCCAGGGGC AGGTGATAGT GGCCGTGAGG 
AGCATCTTCA GCAAGAAGGA AGGTTCTGAC AGACAATGGA ACTACGCCTG CATGCCCACG 
CCACAGAGCC TCGGGGAACC CACGGAGTGC TGGTGGGAGG AGATCAACAG GGCTGGCATG 
GAATGGTACC AGACGTGCTC CAACAATGGG CTGGTGGCAG GATTCCAGAG CCGCTACTTC 
GAGTCAGTGC TGGATCGGGA GTGGCAGTTT TACTGTTGTC GCTACAGCAA GAGGTGCCCA 
TATTCCTGCT GGCTAACAAC AGAATATCCA GGTCACTATG GTGAGGAAAT GGACATGATT 
TCCTACAATT ATGATTACTA TATCCGAGGA GCAACAACCA CTTTCTCTGC AGTGGAAAGG 
GATCGCCAGT GGAAGTTCAT AATGTGCCGG ATGACTGAAT ACGACTGTGA ATTTGCAAAT 
GTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001928.2
CDS	31..636
Translation	MDLSLLWVLLPLVTMAWGQYGDYGYPYQQYHDYSDDGWVNLNRQGFSYQCPQGQVIVAVRSIFSKKEGSDRQWNYACMPTPQSLGEPTECWWEEINRAGMEWYQTCSNNGLVAGFQSRYFESVLDREWQFYCCRYSKRCPYSCWLTTEYPGHYGEEMDMISYNYDYYIRGATTTFSAVERDRQWKFIMCRMTEYDCEFANV

Target ORF information:

RefSeq Version	NM_001937.4
Organism	Homo sapiens(human)
Definition	Homo sapiens dermatopontin (DPT), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001937.4

ORF Insert Sequence:

ATGGACCTCA GTCTTCTCTG GGTACTTCTG CCCCTAGTCA CCATGGCCTG GGGCCAGTAT 
GGCGATTATG GATACCCATA CCAGCAGTAT CATGACTACA GCGATGATGG GTGGGTGAAT 
TTGAACCGGC AAGGCTTCAG CTACCAGTGT CCCCAGGGGC AGGTGATAGT GGCCGTGAGG 
AGCATCTTCA GCAAGAAGGA AGGTTCTGAC AGACAATGGA ACTACGCCTG CATGCCCACG 
CCACAGAGCC TCGGGGAACC CACGGAGTGC TGGTGGGAGG AGATCAACAG GGCTGGCATG 
GAATGGTACC AGACGTGCTC CAACAATGGG CTGGTGGCAG GATTCCAGAG CCGCTACTTC 
GAGTCAGTGC TGGATCGGGA GTGGCAGTTT TACTGTTGTC GCTACAGCAA GAGGTGCCCA 
TATTCCTGCT GGCTAACAAC AGAATATCCA GGTCACTATG GTGAGGAAAT GGACATGATT 
TCCTACAATT ATGATTACTA TATCCGAGGA GCAACAACCA CTTTCTCTGC AGTGGAAAGG 
GATCGCCAGT GGAAGTTCAT AATGTGCCGG ATGACTGAAT ACGACTGTGA ATTTGCAAAT 
GTTTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Effects of Dermatopontin gene silencing on apoptosis and proliferation of osteosarcoma MG?63 cells.
Molecular medicine reports17(1)422-427(2018 Jan)
Xi LC,Ji YX,Yin D,Zhao ZX,Huang SC,Yu SL,Liu BY,Li HY

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.
Journal of proteome research16(8)3083-3091(2017 Aug)
Naba A,Pearce OMT,Del Rosario A,Ma D,Ding H,Rajeeve V,Cutillas PR,Balkwill FR,Hynes RO

Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere's disease.
European journal of human genetics : EJHG25(2)200-207(2017 02)
Mart?n-Sierra C,Gallego-Martinez A,Requena T,Frejo L,Batuecas-Caletr?o A,Lopez-Escamez JA

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DPT cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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