Gene Symbol | DPP6 |
Entrez Gene ID | 1804 |
Full Name | dipeptidyl peptidase like 6 |
Synonyms | DPL1,DPPX,MRD33,VF2 |
General protein information |
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Gene Type | protein-coding |
Organism | Homo sapiens(human) |
Genome | |
Summary | This gene encodes a single-pass type II membrane protein that is a member of the peptidase S9B family of serine proteases. This protein has no detectable protease activity, most likely due to the absence of the conserved serine residue normally present in the catalytic domain of serine proteases. However, it does bind specific voltage-gated potassium channels and alters their expression and biophysical properties. Variations in this gene may be associated with susceptibility to amyotrophic lateral sclerosis and with idiopathic ventricular fibrillation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]. |
Disorder MIM: | |
Disorder Html: | {Ventricular fibrillation, paroxysmal familial, 2}, 612956 (3); Mental retardation, autosomal dominant 33, 616311 (3) |