DNM2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DNM2
Entrez Gene ID	1785
Full Name	dynamin 2
Synonyms	CMT2M,CMTDI1,CMTDIB,DI-CMTB,DYN2,DYNII,LCCS5
General protein information	Preferred Names dynamin 2 Names dynamin-2 dynamin II
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.2
Summary	Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010].
Disorder MIM:	602378
Disorder Html:	Charcot-Marie-Tooth disease, dominant intermediate B, 606482 (3); Centronuclear myopathy 1, 160150 (3); Charcot-Marie-Tooth disease, axonal type 2M, 606482 (3); Lethal congenital contracture syndrome 5, 615368 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001005361.3	NP_001005361.1	dynamin-2 isoform 2
NM_004945.3	NP_004936.2	dynamin-2 isoform 3
NM_001005362.2	NP_001005362.1	dynamin-2 isoform 4
NM_001190716.1	NP_001177645.1	dynamin-2 isoform 5
NM_001005361.2	NP_001005361.1	dynamin-2 isoform 2
NM_001190716.2	NP_001177645.1	dynamin-2 isoform 5
NM_001005360.2	NP_001005360.1	dynamin-2 isoform 1

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DNM2	XP_512382.3
Homo sapiens (human)	DNM2	NP_001005361.1
	DNM2	XP_001103119.1
Danio rerio (zebrafish)	dnm2b	NP_998407.1
Xenopus tropicalis (tropical clawed frog)	dnm2	NP_001011076.1
Canis lupus familiaris (dog)	DNM2	XP_003639779.1
Bos taurus (cattle)	DNM2	NP_001092839.1
Mus musculus (house mouse)	Dnm2	NP_001240822.1
Rattus norvegicus (Norway rat)	Dnm2	NP_037331.1

Gene Ontology
Bibliography

Related articles in PubMed

Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis.
Zhou W, Anderson AL, Turner AP, De Iuliis GN, McCluskey A, McLaughlin EA, Nixon B
Molecular human reproduction23(10)657-673(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Data suggest DNM2/RRAGB- (or DNM2/RRAGC-)dependent endocytosis of extracellular amino acids (AAs) plays critical role in mTORC1 transport/activation; recruitment of mTORC1 from cytoplasm to lysosome is suppressed by DNM2 inhibition; AA deprivation appears to be main cause of mTORC1 inactivation via DNM2 inhibition. (RHEB = Ras homolog enriched in brain; DNM2 = dynamin II; RRAG = Ras-related GTP binding protein)
Title: Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1).

a new AHI-1-BCR-ABL-DNM2 protein complex was uncovered, which regulates leukemic properties of these cells through a unique mechanism of cellular endocytosis and ROS-mediated autophagy. Thus, targeting this complex may facilitate eradication of LSCs for curative therapies
Title: A novel AHI-1-BCR-ABL-DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy.

We demonstrate that the dynamin2 effect on T cell adhesion does not involve integrin affinity regulation but instead relies on its ability to modulate integrin valency.
Title: Dynamin2 controls Rap1 activation and integrin clustering in human T lymphocyte adhesion.

dynamin-2, as a tetramer, might help to establish hemi-fusion and stabilizes the pore during HIV-1 fusion.
Title: Dynamin-2 Stabilizes the HIV-1 Fusion Pore with a Low Oligomeric State.

Thus, dynamin2 contributes to bladder cancer invasion by controlling invadopodia formation in bladder cancer cells and may prove a valuable therapeutic target.
Title: Dynamin2 GTPase contributes to invadopodia formation in invasive bladder cancer cells.

The following DNM2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNM2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22136	NM_004945.3 Latest version!	Homo sapiens dynamin 2 (DNM2), transcript variant 3, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu22370	NM_001005360.2 Latest version!	Homo sapiens dynamin 2 (DNM2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu22607	NM_001005361.3 Latest version!	Homo sapiens dynamin 2 (DNM2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu22803	NM_001005362.2 Latest version!	Homo sapiens dynamin 2 (DNM2), transcript variant 4, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$615.30 $879.00
OHu27392	NM_001190716.2 Latest version!	Homo sapiens dynamin 2 (DNM2), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
View Old Accession Versions >>
OHu22607	NM_001005361.2	Homo sapiens dynamin 2 (DNM2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$189.50-$265.30 $379.00
OHu27392	NM_001190716.1	Homo sapiens dynamin 2 (DNM2), transcript variant 5, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	12-14	$265.30 $379.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DNM2 ( NM_004945.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004936.2 Homo sapiens dynamin 2 (DNM2), transcript variant 3, mRNA.

Price & Availability↑

CloneID	OHu22136
Clone ID Related Accession (Same CDS sequence)	NM_004945.3
Accession Version	NM_004945.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2601bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	dynamin-2 isoform 3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB069057.1, AC011475.6, AC011552.6, AC112707.2, BC054501.1 and BU621654.1. On Jun 26, 2010 this sequence version replaced NM_004945.2. Transcript Variant: This variant (3) lacks an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 3) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L36983.1, BC054501.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAACC GCGGGATGGA AGAGCTGATC CCGCTGGTCA ACAAACTGCA GGACGCCTTC 
AGCTCCATCG GCCAGAGCTG CCACCTGGAC CTGCCGCAGA TCGCTGTAGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTGGAGAAC TTCGTGGGCC GGGACTTCCT TCCCCGCGGT 
TCAGGAATCG TCACCCGGCG GCCTCTCATT CTGCAGCTCA TCTTCTCAAA AACAGAACAT 
GCCGAGTTTT TGCACTGCAA GTCCAAAAAG TTTACAGACT TTGATGAAGT CCGGCAGGAG 
ATTGAAGCAG AGACCGACAG GGTCACGGGG ACCAACAAAG GCATCTCCCC AGTGCCCATC 
AACCTTCGAG TCTACTCGCC ACACGTGTTG AACTTGACCC TCATCGACCT CCCGGGTATC 
ACCAAGGTGC CTGTGGGCGA CCAGCCTCCA GACATCGAGT ACCAGATCAA GGACATGATC 
CTGCAGTTCA TCAGCCGGGA GAGCAGCCTC ATTCTGGCTG TCACGCCCGC CAACATGGAC 
CTGGCCAACT CCGACGCCCT CAAGCTGGCC AAGGAAGTCG ATCCCCAAGG CCTACGGACC 
ATCGGTGTCA TCACCAAGCT TGACCTGATG GACGAGGGCA CCGACGCCAG GGACGTCTTG 
GAGAACAAGT TGCTCCCGTT GAGAAGAGGC TACATTGGCG TGGTGAACCG CAGCCAGAAG 
GATATTGAGG GCAAGAAGGA CATCCGTGCA GCACTGGCAG CTGAGAGGAA GTTCTTCCTC 
TCCCACCCGG CCTACCGGCA CATGGCCGAC CGCATGGGCA CGCCACATCT GCAGAAGACG 
CTGAATCAGC AACTGACCAA CCACATCCGG GAGTCGCTGC CGGCCCTACG TAGCAAACTA 
CAGAGCCAGC TGCTGTCCCT GGAGAAGGAG GTGGAGGAGT ACAAGAACTT TCGGCCCGAC 
GACCCCACCC GCAAAACCAA AGCCCTGCTG CAGATGGTCC AGCAGTTTGG GGTGGATTTT 
GAGAAGAGGA TCGAGGGCTC AGGAGATCAG GTGGACACTC TGGAGCTCTC CGGGGGCGCC 
CGAATCAATC GCATCTTCCA CGAGCGGTTC CCATTTGAGC TGGTGAAGAT GGAGTTTGAC 
GAGAAGGACT TACGACGGGA GATCAGCTAT GCCATTAAGA ACATCCATGG AGTCAGGACC 
GGGCTTTTCA CCCCGGACTT GGCATTCGAG GCCATTGTGA AAAAGCAGGT CGTCAAGCTG 
AAAGAGCCCT GTCTGAAATG TGTCGACCTG GTTATCCAGG AGCTAATCAA TACAGTTAGG 
CAGTGTACCA GTAAGCTCAG TTCCTACCCC CGGTTGCGAG AGGAGACAGA GCGAATCGTC 
ACCACTTACA TCCGGGAACG GGAGGGGAGA ACGAAGGACC AGATTCTTCT GCTGATCGAC 
ATTGAGCAGT CCTACATCAA CACGAACCAT GAGGACTTCA TCGGGTTTGC CAATGCCCAG 
CAGAGGAGCA CGCAGCTGAA CAAGAAGAGA GCCATCCCCA ATCAGGTGAT CCGCAGGGGC 
TGGCTGACCA TCAACAACAT CAGCCTGATG AAAGGCGGCT CCAAGGAGTA CTGGTTTGTG 
CTGACTGCCG AGTCACTGTC CTGGTACAAG GATGAGGAGG AGAAAGAGAA GAAGTACATG 
CTGCCTCTGG ACAACCTCAA GATCCGTGAT GTGGAGAAGG GCTTCATGTC CAACAAGCAC 
GTCTTCGCCA TCTTCAACAC GGAGCAGAGA AACGTCTACA AGGACCTGCG GCAGATCGAG 
CTGGCCTGTG ACTCCCAGGA AGACGTGGAC AGCTGGAAGG CCTCGTTCCT CCGAGCTGGC 
GTCTACCCCG AGAAGGACCA GGCAGAAAAC GAGGATGGGG CCCAGGAGAA CACCTTCTCC 
ATGGACCCCC AACTGGAGCG GCAGGTGGAG ACCATTCGCA ACCTGGTGGA CTCATACGTG 
GCCATCATCA ACAAGTCCAT CCGCGACCTC ATGCCAAAGA CCATCATGCA CCTCATGATC 
AACAATACGA AGGCCTTCAT CCACCACGAG CTGCTGGCCT ACCTATACTC CTCGGCAGAC 
CAGAGCAGCC TCATGGAGGA GTCGGCTGAC CAGGCACAGC GGCGGGACGA CATGCTGCGC 
ATGTACCATG CCCTCAAGGA GGCGCTCAAC ATCATCGGTG ACATCAGCAC CAGCACTGTG 
TCCACGCCTG TACCCCCGCC TGTCGATGAC ACCTGGCTCC AGAGCGCCAG CAGCCACAGC 
CCCACTCCAC AGCGCCGACC GGTGTCCAGC ATACACCCCC CTGGCCGGCC CCCAGCAGTG 
AGGGGCCCCA CTCCAGGGCC CCCCCTGATT CCTGTTCCCG TGGGGGCAGC AGCCTCCTTC 
TCGGCGCCCC CAATCCCATC CCGGCCTGGA CCCCAGAGCG TGTTTGCCAA CAGTGACCTC 
TTCCCAGCCC CGCCTCAGAT CCCATCTCGG CCAGTTCGGA TCCCCCCAGG GATTCCCCCA 
GGAGTGCCCA GCAGAAGACC CCCTGCTGCG CCCAGCCGGC CCACCATTAT CCGCCCAGCC 
GAGCCATCCC TGCTCGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004936.2
CDS	191..2791
Translation	MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLLD

Target ORF information:

RefSeq Version	NM_004945.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dynamin 2 (DNM2), transcript variant 3, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004945.3

ORF Insert Sequence:

ATGGGCAACC GCGGGATGGA AGAGCTGATC CCGCTGGTCA ACAAACTGCA GGACGCCTTC 
AGCTCCATCG GCCAGAGCTG CCACCTGGAC CTGCCGCAGA TCGCTGTAGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTGGAGAAC TTCGTGGGCC GGGACTTCCT TCCCCGCGGT 
TCAGGAATCG TCACCCGGCG GCCTCTCATT CTGCAGCTCA TCTTCTCAAA AACAGAACAT 
GCCGAGTTTT TGCACTGCAA GTCCAAAAAG TTTACAGACT TTGATGAAGT CCGGCAGGAG 
ATTGAAGCAG AGACCGACAG GGTCACGGGG ACCAACAAAG GCATCTCCCC AGTGCCCATC 
AACCTTCGAG TCTACTCGCC ACACGTGTTG AACTTGACCC TCATCGACCT CCCGGGTATC 
ACCAAGGTGC CTGTGGGCGA CCAGCCTCCA GACATCGAGT ACCAGATCAA GGACATGATC 
CTGCAGTTCA TCAGCCGGGA GAGCAGCCTC ATTCTGGCTG TCACGCCCGC CAACATGGAC 
CTGGCCAACT CCGACGCCCT CAAGCTGGCC AAGGAAGTCG ATCCCCAAGG CCTACGGACC 
ATCGGTGTCA TCACCAAGCT TGACCTGATG GACGAGGGCA CCGACGCCAG GGACGTCTTG 
GAGAACAAGT TGCTCCCGTT GAGAAGAGGC TACATTGGCG TGGTGAACCG CAGCCAGAAG 
GATATTGAGG GCAAGAAGGA CATCCGTGCA GCACTGGCAG CTGAGAGGAA GTTCTTCCTC 
TCCCACCCGG CCTACCGGCA CATGGCCGAC CGCATGGGCA CGCCACATCT GCAGAAGACG 
CTGAATCAGC AACTGACCAA CCACATCCGG GAGTCGCTGC CGGCCCTACG TAGCAAACTA 
CAGAGCCAGC TGCTGTCCCT GGAGAAGGAG GTGGAGGAGT ACAAGAACTT TCGGCCCGAC 
GACCCCACCC GCAAAACCAA AGCCCTGCTG CAGATGGTCC AGCAGTTTGG GGTGGATTTT 
GAGAAGAGGA TCGAGGGCTC AGGAGATCAG GTGGACACTC TGGAGCTCTC CGGGGGCGCC 
CGAATCAATC GCATCTTCCA CGAGCGGTTC CCATTTGAGC TGGTGAAGAT GGAGTTTGAC 
GAGAAGGACT TACGACGGGA GATCAGCTAT GCCATTAAGA ACATCCATGG AGTCAGGACC 
GGGCTTTTCA CCCCGGACTT GGCATTCGAG GCCATTGTGA AAAAGCAGGT CGTCAAGCTG 
AAAGAGCCCT GTCTGAAATG TGTCGACCTG GTTATCCAGG AGCTAATCAA TACAGTTAGG 
CAGTGTACCA GTAAGCTCAG TTCCTACCCC CGGTTGCGAG AGGAGACAGA GCGAATCGTC 
ACCACTTACA TCCGGGAACG GGAGGGGAGA ACGAAGGACC AGATTCTTCT GCTGATCGAC 
ATTGAGCAGT CCTACATCAA CACGAACCAT GAGGACTTCA TCGGGTTTGC CAATGCCCAG 
CAGAGGAGCA CGCAGCTGAA CAAGAAGAGA GCCATCCCCA ATCAGGTGAT CCGCAGGGGC 
TGGCTGACCA TCAACAACAT CAGCCTGATG AAAGGCGGCT CCAAGGAGTA CTGGTTTGTG 
CTGACTGCCG AGTCACTGTC CTGGTACAAG GATGAGGAGG AGAAAGAGAA GAAGTACATG 
CTGCCTCTGG ACAACCTCAA GATCCGTGAT GTGGAGAAGG GCTTCATGTC CAACAAGCAC 
GTCTTCGCCA TCTTCAACAC GGAGCAGAGA AACGTCTACA AGGACCTGCG GCAGATCGAG 
CTGGCCTGTG ACTCCCAGGA AGACGTGGAC AGCTGGAAGG CCTCGTTCCT CCGAGCTGGC 
GTCTACCCCG AGAAGGACCA GGCAGAAAAC GAGGATGGGG CCCAGGAGAA CACCTTCTCC 
ATGGACCCCC AACTGGAGCG GCAGGTGGAG ACCATTCGCA ACCTGGTGGA CTCATACGTG 
GCCATCATCA ACAAGTCCAT CCGCGACCTC ATGCCAAAGA CCATCATGCA CCTCATGATC 
AACAATACGA AGGCCTTCAT CCACCACGAG CTGCTGGCCT ACCTATACTC CTCGGCAGAC 
CAGAGCAGCC TCATGGAGGA GTCGGCTGAC CAGGCACAGC GGCGGGACGA CATGCTGCGC 
ATGTACCATG CCCTCAAGGA GGCGCTCAAC ATCATCGGTG ACATCAGCAC CAGCACTGTG 
TCCACGCCTG TACCCCCGCC TGTCGATGAC ACCTGGCTCC AGAGCGCCAG CAGCCACAGC 
CCCACTCCAC AGCGCCGACC GGTGTCCAGC ATACACCCCC CTGGCCGGCC CCCAGCAGTG 
AGGGGCCCCA CTCCAGGGCC CCCCCTGATT CCTGTTCCCG TGGGGGCAGC AGCCTCCTTC 
TCGGCGCCCC CAATCCCATC CCGGCCTGGA CCCCAGAGCG TGTTTGCCAA CAGTGACCTC 
TTCCCAGCCC CGCCTCAGAT CCCATCTCGG CCAGTTCGGA TCCCCCCAGG GATTCCCCCA 
GGAGTGCCCA GCAGAAGACC CCCTGCTGCG CCCAGCCGGC CCACCATTAT CCGCCCAGCC 
GAGCCATCCC TGCTCGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNM2 ( NM_001005360.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005360.1 Homo sapiens dynamin 2 (DNM2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu22370
Clone ID Related Accession (Same CDS sequence)	NM_001005360.2
Accession Version	NM_001005360.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2613bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-27
Organism	Homo sapiens(human)
Product	dynamin-2 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB069057.1, AC011475.6, AC011552.6, AC112707.2, BC039596.1, BC054501.1 and BU621654.1. This sequence is a reference standard in the RefSeqGene project. On Jun 26, 2010 this sequence version replaced NM_001005360.1. Transcript Variant: This variant (1) encodes one of the longer isoforms (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC039596.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAACC GCGGGATGGA AGAGCTGATC CCGCTGGTCA ACAAACTGCA GGACGCCTTC 
AGCTCCATCG GCCAGAGCTG CCACCTGGAC CTGCCGCAGA TCGCTGTAGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTGGAGAAC TTCGTGGGCC GGGACTTCCT TCCCCGCGGT 
TCAGGAATCG TCACCCGGCG GCCTCTCATT CTGCAGCTCA TCTTCTCAAA AACAGAACAT 
GCCGAGTTTT TGCACTGCAA GTCCAAAAAG TTTACAGACT TTGATGAAGT CCGGCAGGAG 
ATTGAAGCAG AGACCGACAG GGTCACGGGG ACCAACAAAG GCATCTCCCC AGTGCCCATC 
AACCTTCGAG TCTACTCGCC ACACGTGTTG AACTTGACCC TCATCGACCT CCCGGGTATC 
ACCAAGGTGC CTGTGGGCGA CCAGCCTCCA GACATCGAGT ACCAGATCAA GGACATGATC 
CTGCAGTTCA TCAGCCGGGA GAGCAGCCTC ATTCTGGCTG TCACGCCCGC CAACATGGAC 
CTGGCCAACT CCGACGCCCT CAAGCTGGCC AAGGAAGTCG ATCCCCAAGG CCTACGGACC 
ATCGGTGTCA TCACCAAGCT TGACCTGATG GACGAGGGCA CCGACGCCAG GGACGTCTTG 
GAGAACAAGT TGCTCCCGTT GAGAAGAGGC TACATTGGCG TGGTGAACCG CAGCCAGAAG 
GATATTGAGG GCAAGAAGGA CATCCGTGCA GCACTGGCAG CTGAGAGGAA GTTCTTCCTC 
TCCCACCCGG CCTACCGGCA CATGGCCGAC CGCATGGGCA CGCCACATCT GCAGAAGACG 
CTGAATCAGC AACTGACCAA CCACATCCGG GAGTCGCTGC CGGCCCTACG TAGCAAACTA 
CAGAGCCAGC TGCTGTCCCT GGAGAAGGAG GTGGAGGAGT ACAAGAACTT TCGGCCCGAC 
GACCCCACCC GCAAAACCAA AGCCCTGCTG CAGATGGTCC AGCAGTTTGG GGTGGATTTT 
GAGAAGAGGA TCGAGGGCTC AGGAGATCAG GTGGACACTC TGGAGCTCTC CGGGGGCGCC 
CGAATCAATC GCATCTTCCA CGAGCGGTTC CCATTTGAGC TGGTGAAGAT GGAGTTTGAC 
GAGAAGGACT TACGACGGGA GATCAGCTAT GCCATTAAGA ACATCCATGG AGTCAGGACC 
GGGCTTTTCA CCCCGGACTT GGCATTCGAG GCCATTGTGA AAAAGCAGGT CGTCAAGCTG 
AAAGAGCCCT GTCTGAAATG TGTCGACCTG GTTATCCAGG AGCTAATCAA TACAGTTAGG 
CAGTGTACCA GTAAGCTCAG TTCCTACCCC CGGTTGCGAG AGGAGACAGA GCGAATCGTC 
ACCACTTACA TCCGGGAACG GGAGGGGAGA ACGAAGGACC AGATTCTTCT GCTGATCGAC 
ATTGAGCAGT CCTACATCAA CACGAACCAT GAGGACTTCA TCGGGTTTGC CAATGCCCAG 
CAGAGGAGCA CGCAGCTGAA CAAGAAGAGA GCCATCCCCA ATCAGGGGGA GATCCTGGTG 
ATCCGCAGGG GCTGGCTGAC CATCAACAAC ATCAGCCTGA TGAAAGGCGG CTCCAAGGAG 
TACTGGTTTG TGCTGACTGC CGAGTCACTG TCCTGGTACA AGGATGAGGA GGAGAAAGAG 
AAGAAGTACA TGCTGCCTCT GGACAACCTC AAGATCCGTG ATGTGGAGAA GGGCTTCATG 
TCCAACAAGC ACGTCTTCGC CATCTTCAAC ACGGAGCAGA GAAACGTCTA CAAGGACCTG 
CGGCAGATCG AGCTGGCCTG TGACTCCCAG GAAGACGTGG ACAGCTGGAA GGCCTCGTTC 
CTCCGAGCTG GCGTCTACCC CGAGAAGGAC CAGGCAGAAA ACGAGGATGG GGCCCAGGAG 
AACACCTTCT CCATGGACCC CCAACTGGAG CGGCAGGTGG AGACCATTCG CAACCTGGTG 
GACTCATACG TGGCCATCAT CAACAAGTCC ATCCGCGACC TCATGCCAAA GACCATCATG 
CACCTCATGA TCAACAATAC GAAGGCCTTC ATCCACCACG AGCTGCTGGC CTACCTATAC 
TCCTCGGCAG ACCAGAGCAG CCTCATGGAG GAGTCGGCTG ACCAGGCACA GCGGCGGGAC 
GACATGCTGC GCATGTACCA TGCCCTCAAG GAGGCGCTCA ACATCATCGG TGACATCAGC 
ACCAGCACTG TGTCCACGCC TGTACCCCCG CCTGTCGATG ACACCTGGCT CCAGAGCGCC 
AGCAGCCACA GCCCCACTCC ACAGCGCCGA CCGGTGTCCA GCATACACCC CCCTGGCCGG 
CCCCCAGCAG TGAGGGGCCC CACTCCAGGG CCCCCCCTGA TTCCTGTTCC CGTGGGGGCA 
GCAGCCTCCT TCTCGGCGCC CCCAATCCCA TCCCGGCCTG GACCCCAGAG CGTGTTTGCC 
AACAGTGACC TCTTCCCAGC CCCGCCTCAG ATCCCATCTC GGCCAGTTCG GATCCCCCCA 
GGGATTCCCC CAGGAGTGCC CAGCAGAAGA CCCCCTGCTG CGCCCAGCCG GCCCACCATT 
ATCCGCCCAG CCGAGCCATC CCTGCTCGAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005360.1
CDS	191..2803
Translation	MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLLD

Target ORF information:

RefSeq Version	NM_001005360.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dynamin 2 (DNM2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005360.2

ORF Insert Sequence:

ATGGGCAACC GCGGGATGGA AGAGCTGATC CCGCTGGTCA ACAAACTGCA GGACGCCTTC 
AGCTCCATCG GCCAGAGCTG CCACCTGGAC CTGCCGCAGA TCGCTGTAGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTGGAGAAC TTCGTGGGCC GGGACTTCCT TCCCCGCGGT 
TCAGGAATCG TCACCCGGCG GCCTCTCATT CTGCAGCTCA TCTTCTCAAA AACAGAACAT 
GCCGAGTTTT TGCACTGCAA GTCCAAAAAG TTTACAGACT TTGATGAAGT CCGGCAGGAG 
ATTGAAGCAG AGACCGACAG GGTCACGGGG ACCAACAAAG GCATCTCCCC AGTGCCCATC 
AACCTTCGAG TCTACTCGCC ACACGTGTTG AACTTGACCC TCATCGACCT CCCGGGTATC 
ACCAAGGTGC CTGTGGGCGA CCAGCCTCCA GACATCGAGT ACCAGATCAA GGACATGATC 
CTGCAGTTCA TCAGCCGGGA GAGCAGCCTC ATTCTGGCTG TCACGCCCGC CAACATGGAC 
CTGGCCAACT CCGACGCCCT CAAGCTGGCC AAGGAAGTCG ATCCCCAAGG CCTACGGACC 
ATCGGTGTCA TCACCAAGCT TGACCTGATG GACGAGGGCA CCGACGCCAG GGACGTCTTG 
GAGAACAAGT TGCTCCCGTT GAGAAGAGGC TACATTGGCG TGGTGAACCG CAGCCAGAAG 
GATATTGAGG GCAAGAAGGA CATCCGTGCA GCACTGGCAG CTGAGAGGAA GTTCTTCCTC 
TCCCACCCGG CCTACCGGCA CATGGCCGAC CGCATGGGCA CGCCACATCT GCAGAAGACG 
CTGAATCAGC AACTGACCAA CCACATCCGG GAGTCGCTGC CGGCCCTACG TAGCAAACTA 
CAGAGCCAGC TGCTGTCCCT GGAGAAGGAG GTGGAGGAGT ACAAGAACTT TCGGCCCGAC 
GACCCCACCC GCAAAACCAA AGCCCTGCTG CAGATGGTCC AGCAGTTTGG GGTGGATTTT 
GAGAAGAGGA TCGAGGGCTC AGGAGATCAG GTGGACACTC TGGAGCTCTC CGGGGGCGCC 
CGAATCAATC GCATCTTCCA CGAGCGGTTC CCATTTGAGC TGGTGAAGAT GGAGTTTGAC 
GAGAAGGACT TACGACGGGA GATCAGCTAT GCCATTAAGA ACATCCATGG AGTCAGGACC 
GGGCTTTTCA CCCCGGACTT GGCATTCGAG GCCATTGTGA AAAAGCAGGT CGTCAAGCTG 
AAAGAGCCCT GTCTGAAATG TGTCGACCTG GTTATCCAGG AGCTAATCAA TACAGTTAGG 
CAGTGTACCA GTAAGCTCAG TTCCTACCCC CGGTTGCGAG AGGAGACAGA GCGAATCGTC 
ACCACTTACA TCCGGGAACG GGAGGGGAGA ACGAAGGACC AGATTCTTCT GCTGATCGAC 
ATTGAGCAGT CCTACATCAA CACGAACCAT GAGGACTTCA TCGGGTTTGC CAATGCCCAG 
CAGAGGAGCA CGCAGCTGAA CAAGAAGAGA GCCATCCCCA ATCAGGGGGA GATCCTGGTG 
ATCCGCAGGG GCTGGCTGAC CATCAACAAC ATCAGCCTGA TGAAAGGCGG CTCCAAGGAG 
TACTGGTTTG TGCTGACTGC CGAGTCACTG TCCTGGTACA AGGATGAGGA GGAGAAAGAG 
AAGAAGTACA TGCTGCCTCT GGACAACCTC AAGATCCGTG ATGTGGAGAA GGGCTTCATG 
TCCAACAAGC ACGTCTTCGC CATCTTCAAC ACGGAGCAGA GAAACGTCTA CAAGGACCTG 
CGGCAGATCG AGCTGGCCTG TGACTCCCAG GAAGACGTGG ACAGCTGGAA GGCCTCGTTC 
CTCCGAGCTG GCGTCTACCC CGAGAAGGAC CAGGCAGAAA ACGAGGATGG GGCCCAGGAG 
AACACCTTCT CCATGGACCC CCAACTGGAG CGGCAGGTGG AGACCATTCG CAACCTGGTG 
GACTCATACG TGGCCATCAT CAACAAGTCC ATCCGCGACC TCATGCCAAA GACCATCATG 
CACCTCATGA TCAACAATAC GAAGGCCTTC ATCCACCACG AGCTGCTGGC CTACCTATAC 
TCCTCGGCAG ACCAGAGCAG CCTCATGGAG GAGTCGGCTG ACCAGGCACA GCGGCGGGAC 
GACATGCTGC GCATGTACCA TGCCCTCAAG GAGGCGCTCA ACATCATCGG TGACATCAGC 
ACCAGCACTG TGTCCACGCC TGTACCCCCG CCTGTCGATG ACACCTGGCT CCAGAGCGCC 
AGCAGCCACA GCCCCACTCC ACAGCGCCGA CCGGTGTCCA GCATACACCC CCCTGGCCGG 
CCCCCAGCAG TGAGGGGCCC CACTCCAGGG CCCCCCCTGA TTCCTGTTCC CGTGGGGGCA 
GCAGCCTCCT TCTCGGCGCC CCCAATCCCA TCCCGGCCTG GACCCCAGAG CGTGTTTGCC 
AACAGTGACC TCTTCCCAGC CCCGCCTCAG ATCCCATCTC GGCCAGTTCG GATCCCCCCA 
GGGATTCCCC CAGGAGTGCC CAGCAGAAGA CCCCCTGCTG CGCCCAGCCG GCCCACCATT 
ATCCGCCCAG CCGAGCCATC CCTGCTCGAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNM2 ( NM_001005361.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005361.1 Homo sapiens dynamin 2 (DNM2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22607
Clone ID Related Accession (Same CDS sequence)	NM_001005361.3 , NM_001005361.2
Accession Version	NM_001005361.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2613bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-04
Organism	Homo sapiens(human)
Product	dynamin-2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC011475.6, AC011552.6, AC112707.2, BC039596.1 and AK097875.1. On Dec 4, 2019 this sequence version replaced NM_001005361.2. Transcript Variant: This variant (2) lacks an alternate in-frame exon and includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is the same length as isoform 1 but differs in an internal region, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR7346977.1515307.1, SRR1660807.111479.1 [ECO:0000332] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on manual assertion, conservation, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGGCAACC GCGGGATGGA AGAGCTGATC CCGCTGGTCA ACAAACTGCA GGACGCCTTC 
AGCTCCATCG GCCAGAGCTG CCACCTGGAC CTGCCGCAGA TCGCTGTAGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTGGAGAAC TTCGTGGGCC GGGACTTCCT TCCCCGCGGT 
TCAGGAATCG TCACCCGGCG GCCTCTCATT CTGCAGCTCA TCTTCTCAAA AACAGAACAT 
GCCGAGTTTT TGCACTGCAA GTCCAAAAAG TTTACAGACT TTGATGAAGT CCGGCAGGAG 
ATTGAAGCAG AGACCGACAG GGTCACGGGG ACCAACAAAG GCATCTCCCC AGTGCCCATC 
AACCTTCGAG TCTACTCGCC ACACGTGTTG AACTTGACCC TCATCGACCT CCCGGGTATC 
ACCAAGGTGC CTGTGGGCGA CCAGCCTCCA GACATCGAGT ACCAGATCAA GGACATGATC 
CTGCAGTTCA TCAGCCGGGA GAGCAGCCTC ATTCTGGCTG TCACGCCCGC CAACATGGAC 
CTGGCCAACT CCGACGCCCT CAAGCTGGCC AAGGAAGTCG ATCCCCAAGG CCTACGGACC 
ATCGGTGTCA TCACCAAGCT TGACCTGATG GACGAGGGCA CCGACGCCAG GGACGTCTTG 
GAGAACAAGT TGCTCCCGTT GAGAAGAGGC TACATTGGCG TGGTGAACCG CAGCCAGAAG 
GATATTGAGG GCAAGAAGGA CATCCGTGCA GCACTGGCAG CTGAGAGGAA GTTCTTCCTC 
TCCCACCCGG CCTACCGGCA CATGGCCGAC CGCATGGGCA CGCCACATCT GCAGAAGACG 
CTGAATCAGC AACTGACCAA CCACATCCGG GAGTCGCTGC CGGCCCTACG TAGCAAACTA 
CAGAGCCAGC TGCTGTCCCT GGAGAAGGAG GTGGAGGAGT ACAAGAACTT TCGGCCCGAC 
GACCCCACCC GCAAAACCAA AGCCCTGCTG CAGATGGTCC AGCAGTTTGG GGTGGATTTT 
GAGAAGAGGA TCGAGGGCTC AGGAGATCAG GTGGACACTC TGGAGCTCTC CGGGGGCGCC 
CGAATCAATC GCATCTTCCA CGAGCGGTTC CCATTTGAGC TGGTGAAGAT GGAGTTTGAC 
GAGAAGGACT TACGACGGGA GATCAGCTAT GCCATTAAGA ACATCCATGG AGTCAGGACG 
GGGCTCTTCA CCCCCGACAT GGCCTTTGAA GCCATTGTGA AAAAACAGAT TGTAAAACTC 
AAAGAGCCGA GTTTGAAGTG TGTTGATCTC GTGGTCTCAG AGCTGGCCAC GGTCATAAAA 
AAGTGTGCCG AGAAGCTCAG TTCCTACCCC CGGTTGCGAG AGGAGACAGA GCGAATCGTC 
ACCACTTACA TCCGGGAACG GGAGGGGAGA ACGAAGGACC AGATTCTTCT GCTGATCGAC 
ATTGAGCAGT CCTACATCAA CACGAACCAT GAGGACTTCA TCGGGTTTGC CAATGCCCAG 
CAGAGGAGCA CGCAGCTGAA CAAGAAGAGA GCCATCCCCA ATCAGGGGGA GATCCTGGTG 
ATCCGCAGGG GCTGGCTGAC CATCAACAAC ATCAGCCTGA TGAAAGGCGG CTCCAAGGAG 
TACTGGTTTG TGCTGACTGC CGAGTCACTG TCCTGGTACA AGGATGAGGA GGAGAAAGAG 
AAGAAGTACA TGCTGCCTCT GGACAACCTC AAGATCCGTG ATGTGGAGAA GGGCTTCATG 
TCCAACAAGC ACGTCTTCGC CATCTTCAAC ACGGAGCAGA GAAACGTCTA CAAGGACCTG 
CGGCAGATCG AGCTGGCCTG TGACTCCCAG GAAGACGTGG ACAGCTGGAA GGCCTCGTTC 
CTCCGAGCTG GCGTCTACCC CGAGAAGGAC CAGGCAGAAA ACGAGGATGG GGCCCAGGAG 
AACACCTTCT CCATGGACCC CCAACTGGAG CGGCAGGTGG AGACCATTCG CAACCTGGTG 
GACTCATACG TGGCCATCAT CAACAAGTCC ATCCGCGACC TCATGCCAAA GACCATCATG 
CACCTCATGA TCAACAATAC GAAGGCCTTC ATCCACCACG AGCTGCTGGC CTACCTATAC 
TCCTCGGCAG ACCAGAGCAG CCTCATGGAG GAGTCGGCTG ACCAGGCACA GCGGCGGGAC 
GACATGCTGC GCATGTACCA TGCCCTCAAG GAGGCGCTCA ACATCATCGG TGACATCAGC 
ACCAGCACTG TGTCCACGCC TGTACCCCCG CCTGTCGATG ACACCTGGCT CCAGAGCGCC 
AGCAGCCACA GCCCCACTCC ACAGCGCCGA CCGGTGTCCA GCATACACCC CCCTGGCCGG 
CCCCCAGCAG TGAGGGGCCC CACTCCAGGG CCCCCCCTGA TTCCTGTTCC CGTGGGGGCA 
GCAGCCTCCT TCTCGGCGCC CCCAATCCCA TCCCGGCCTG GACCCCAGAG CGTGTTTGCC 
AACAGTGACC TCTTCCCAGC CCCGCCTCAG ATCCCATCTC GGCCAGTTCG GATCCCCCCA 
GGGATTCCCC CAGGAGTGCC CAGCAGAAGA CCCCCTGCTG CGCCCAGCCG GCCCACCATT 
ATCCGCCCAG CCGAGCCATC CCTGCTCGAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005361.1
CDS	165..2777
Translation	MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLLD

Target ORF information:

RefSeq Version	NM_001005361.3
Organism	Homo sapiens(human)
Definition	Homo sapiens dynamin 2 (DNM2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005361.3

ORF Insert Sequence:

ATGGGCAACC GCGGGATGGA AGAGCTGATC CCGCTGGTCA ACAAACTGCA GGACGCCTTC 
AGCTCCATCG GCCAGAGCTG CCACCTGGAC CTGCCGCAGA TCGCTGTAGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTGGAGAAC TTCGTGGGCC GGGACTTCCT TCCCCGCGGT 
TCAGGAATCG TCACCCGGCG GCCTCTCATT CTGCAGCTCA TCTTCTCAAA AACAGAACAT 
GCCGAGTTTT TGCACTGCAA GTCCAAAAAG TTTACAGACT TTGATGAAGT CCGGCAGGAG 
ATTGAAGCAG AGACCGACAG GGTCACGGGG ACCAACAAAG GCATCTCCCC AGTGCCCATC 
AACCTTCGAG TCTACTCGCC ACACGTGTTG AACTTGACCC TCATCGACCT CCCGGGTATC 
ACCAAGGTGC CTGTGGGCGA CCAGCCTCCA GACATCGAGT ACCAGATCAA GGACATGATC 
CTGCAGTTCA TCAGCCGGGA GAGCAGCCTC ATTCTGGCTG TCACGCCCGC CAACATGGAC 
CTGGCCAACT CCGACGCCCT CAAGCTGGCC AAGGAAGTCG ATCCCCAAGG CCTACGGACC 
ATCGGTGTCA TCACCAAGCT TGACCTGATG GACGAGGGCA CCGACGCCAG GGACGTCTTG 
GAGAACAAGT TGCTCCCGTT GAGAAGAGGC TACATTGGCG TGGTGAACCG CAGCCAGAAG 
GATATTGAGG GCAAGAAGGA CATCCGTGCA GCACTGGCAG CTGAGAGGAA GTTCTTCCTC 
TCCCACCCGG CCTACCGGCA CATGGCCGAC CGCATGGGCA CGCCACATCT GCAGAAGACG 
CTGAATCAGC AACTGACCAA CCACATCCGG GAGTCGCTGC CGGCCCTACG TAGCAAACTA 
CAGAGCCAGC TGCTGTCCCT GGAGAAGGAG GTGGAGGAGT ACAAGAACTT TCGGCCCGAC 
GACCCCACCC GCAAAACCAA AGCCCTGCTG CAGATGGTCC AGCAGTTTGG GGTGGATTTT 
GAGAAGAGGA TCGAGGGCTC AGGAGATCAG GTGGACACTC TGGAGCTCTC CGGGGGCGCC 
CGAATCAATC GCATCTTCCA CGAGCGGTTC CCATTTGAGC TGGTGAAGAT GGAGTTTGAC 
GAGAAGGACT TACGACGGGA GATCAGCTAT GCCATTAAGA ACATCCATGG AGTCAGGACG 
GGGCTCTTCA CCCCCGACAT GGCCTTTGAA GCCATTGTGA AAAAACAGAT TGTAAAACTC 
AAAGAGCCGA GTTTGAAGTG TGTTGATCTC GTGGTCTCAG AGCTGGCCAC GGTCATAAAA 
AAGTGTGCCG AGAAGCTCAG TTCCTACCCC CGGTTGCGAG AGGAGACAGA GCGAATCGTC 
ACCACTTACA TCCGGGAACG GGAGGGGAGA ACGAAGGACC AGATTCTTCT GCTGATCGAC 
ATTGAGCAGT CCTACATCAA CACGAACCAT GAGGACTTCA TCGGGTTTGC CAATGCCCAG 
CAGAGGAGCA CGCAGCTGAA CAAGAAGAGA GCCATCCCCA ATCAGGGGGA GATCCTGGTG 
ATCCGCAGGG GCTGGCTGAC CATCAACAAC ATCAGCCTGA TGAAAGGCGG CTCCAAGGAG 
TACTGGTTTG TGCTGACTGC CGAGTCACTG TCCTGGTACA AGGATGAGGA GGAGAAAGAG 
AAGAAGTACA TGCTGCCTCT GGACAACCTC AAGATCCGTG ATGTGGAGAA GGGCTTCATG 
TCCAACAAGC ACGTCTTCGC CATCTTCAAC ACGGAGCAGA GAAACGTCTA CAAGGACCTG 
CGGCAGATCG AGCTGGCCTG TGACTCCCAG GAAGACGTGG ACAGCTGGAA GGCCTCGTTC 
CTCCGAGCTG GCGTCTACCC CGAGAAGGAC CAGGCAGAAA ACGAGGATGG GGCCCAGGAG 
AACACCTTCT CCATGGACCC CCAACTGGAG CGGCAGGTGG AGACCATTCG CAACCTGGTG 
GACTCATACG TGGCCATCAT CAACAAGTCC ATCCGCGACC TCATGCCAAA GACCATCATG 
CACCTCATGA TCAACAATAC GAAGGCCTTC ATCCACCACG AGCTGCTGGC CTACCTATAC 
TCCTCGGCAG ACCAGAGCAG CCTCATGGAG GAGTCGGCTG ACCAGGCACA GCGGCGGGAC 
GACATGCTGC GCATGTACCA TGCCCTCAAG GAGGCGCTCA ACATCATCGG TGACATCAGC 
ACCAGCACTG TGTCCACGCC TGTACCCCCG CCTGTCGATG ACACCTGGCT CCAGAGCGCC 
AGCAGCCACA GCCCCACTCC ACAGCGCCGA CCGGTGTCCA GCATACACCC CCCTGGCCGG 
CCCCCAGCAG TGAGGGGCCC CACTCCAGGG CCCCCCCTGA TTCCTGTTCC CGTGGGGGCA 
GCAGCCTCCT TCTCGGCGCC CCCAATCCCA TCCCGGCCTG GACCCCAGAG CGTGTTTGCC 
AACAGTGACC TCTTCCCAGC CCCGCCTCAG ATCCCATCTC GGCCAGTTCG GATCCCCCCA 
GGGATTCCCC CAGGAGTGCC CAGCAGAAGA CCCCCTGCTG CGCCCAGCCG GCCCACCATT 
ATCCGCCCAG CCGAGCCATC CCTGCTCGAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNM2 ( NM_001005361.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005361.1 Homo sapiens dynamin 2 (DNM2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu22607
Clone ID Related Accession (Same CDS sequence)	NM_001005361.3 , NM_001005361.2
Accession Version	NM_001005361.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2613bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-18
Organism	Homo sapiens(human)
Product	dynamin-2 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB069057.1, AC011475.6, AC011552.6, AC112707.2, BC039596.1, AK097875.1 and BU621654.1. This sequence is a reference standard in the RefSeqGene project. On Jun 26, 2010 this sequence version replaced NM_001005361.1. Transcript Variant: This variant (2) lacks an alternate in-frame exon and includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 2) is the same length as isoform 1 but differs in an internal region, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.111479.1, SRR1660803.52575.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAACC GCGGGATGGA AGAGCTGATC CCGCTGGTCA ACAAACTGCA GGACGCCTTC 
AGCTCCATCG GCCAGAGCTG CCACCTGGAC CTGCCGCAGA TCGCTGTAGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTGGAGAAC TTCGTGGGCC GGGACTTCCT TCCCCGCGGT 
TCAGGAATCG TCACCCGGCG GCCTCTCATT CTGCAGCTCA TCTTCTCAAA AACAGAACAT 
GCCGAGTTTT TGCACTGCAA GTCCAAAAAG TTTACAGACT TTGATGAAGT CCGGCAGGAG 
ATTGAAGCAG AGACCGACAG GGTCACGGGG ACCAACAAAG GCATCTCCCC AGTGCCCATC 
AACCTTCGAG TCTACTCGCC ACACGTGTTG AACTTGACCC TCATCGACCT CCCGGGTATC 
ACCAAGGTGC CTGTGGGCGA CCAGCCTCCA GACATCGAGT ACCAGATCAA GGACATGATC 
CTGCAGTTCA TCAGCCGGGA GAGCAGCCTC ATTCTGGCTG TCACGCCCGC CAACATGGAC 
CTGGCCAACT CCGACGCCCT CAAGCTGGCC AAGGAAGTCG ATCCCCAAGG CCTACGGACC 
ATCGGTGTCA TCACCAAGCT TGACCTGATG GACGAGGGCA CCGACGCCAG GGACGTCTTG 
GAGAACAAGT TGCTCCCGTT GAGAAGAGGC TACATTGGCG TGGTGAACCG CAGCCAGAAG 
GATATTGAGG GCAAGAAGGA CATCCGTGCA GCACTGGCAG CTGAGAGGAA GTTCTTCCTC 
TCCCACCCGG CCTACCGGCA CATGGCCGAC CGCATGGGCA CGCCACATCT GCAGAAGACG 
CTGAATCAGC AACTGACCAA CCACATCCGG GAGTCGCTGC CGGCCCTACG TAGCAAACTA 
CAGAGCCAGC TGCTGTCCCT GGAGAAGGAG GTGGAGGAGT ACAAGAACTT TCGGCCCGAC 
GACCCCACCC GCAAAACCAA AGCCCTGCTG CAGATGGTCC AGCAGTTTGG GGTGGATTTT 
GAGAAGAGGA TCGAGGGCTC AGGAGATCAG GTGGACACTC TGGAGCTCTC CGGGGGCGCC 
CGAATCAATC GCATCTTCCA CGAGCGGTTC CCATTTGAGC TGGTGAAGAT GGAGTTTGAC 
GAGAAGGACT TACGACGGGA GATCAGCTAT GCCATTAAGA ACATCCATGG AGTCAGGACG 
GGGCTCTTCA CCCCCGACAT GGCCTTTGAA GCCATTGTGA AAAAACAGAT TGTAAAACTC 
AAAGAGCCGA GTTTGAAGTG TGTTGATCTC GTGGTCTCAG AGCTGGCCAC GGTCATAAAA 
AAGTGTGCCG AGAAGCTCAG TTCCTACCCC CGGTTGCGAG AGGAGACAGA GCGAATCGTC 
ACCACTTACA TCCGGGAACG GGAGGGGAGA ACGAAGGACC AGATTCTTCT GCTGATCGAC 
ATTGAGCAGT CCTACATCAA CACGAACCAT GAGGACTTCA TCGGGTTTGC CAATGCCCAG 
CAGAGGAGCA CGCAGCTGAA CAAGAAGAGA GCCATCCCCA ATCAGGGGGA GATCCTGGTG 
ATCCGCAGGG GCTGGCTGAC CATCAACAAC ATCAGCCTGA TGAAAGGCGG CTCCAAGGAG 
TACTGGTTTG TGCTGACTGC CGAGTCACTG TCCTGGTACA AGGATGAGGA GGAGAAAGAG 
AAGAAGTACA TGCTGCCTCT GGACAACCTC AAGATCCGTG ATGTGGAGAA GGGCTTCATG 
TCCAACAAGC ACGTCTTCGC CATCTTCAAC ACGGAGCAGA GAAACGTCTA CAAGGACCTG 
CGGCAGATCG AGCTGGCCTG TGACTCCCAG GAAGACGTGG ACAGCTGGAA GGCCTCGTTC 
CTCCGAGCTG GCGTCTACCC CGAGAAGGAC CAGGCAGAAA ACGAGGATGG GGCCCAGGAG 
AACACCTTCT CCATGGACCC CCAACTGGAG CGGCAGGTGG AGACCATTCG CAACCTGGTG 
GACTCATACG TGGCCATCAT CAACAAGTCC ATCCGCGACC TCATGCCAAA GACCATCATG 
CACCTCATGA TCAACAATAC GAAGGCCTTC ATCCACCACG AGCTGCTGGC CTACCTATAC 
TCCTCGGCAG ACCAGAGCAG CCTCATGGAG GAGTCGGCTG ACCAGGCACA GCGGCGGGAC 
GACATGCTGC GCATGTACCA TGCCCTCAAG GAGGCGCTCA ACATCATCGG TGACATCAGC 
ACCAGCACTG TGTCCACGCC TGTACCCCCG CCTGTCGATG ACACCTGGCT CCAGAGCGCC 
AGCAGCCACA GCCCCACTCC ACAGCGCCGA CCGGTGTCCA GCATACACCC CCCTGGCCGG 
CCCCCAGCAG TGAGGGGCCC CACTCCAGGG CCCCCCCTGA TTCCTGTTCC CGTGGGGGCA 
GCAGCCTCCT TCTCGGCGCC CCCAATCCCA TCCCGGCCTG GACCCCAGAG CGTGTTTGCC 
AACAGTGACC TCTTCCCAGC CCCGCCTCAG ATCCCATCTC GGCCAGTTCG GATCCCCCCA 
GGGATTCCCC CAGGAGTGCC CAGCAGAAGA CCCCCTGCTG CGCCCAGCCG GCCCACCATT 
ATCCGCCCAG CCGAGCCATC CCTGCTCGAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005361.1
CDS	191..2803
Translation	MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLLD

Target ORF information:

RefSeq Version	NM_001005361.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dynamin 2 (DNM2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005361.2

ORF Insert Sequence:

ATGGGCAACC GCGGGATGGA AGAGCTGATC CCGCTGGTCA ACAAACTGCA GGACGCCTTC 
AGCTCCATCG GCCAGAGCTG CCACCTGGAC CTGCCGCAGA TCGCTGTAGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTGGAGAAC TTCGTGGGCC GGGACTTCCT TCCCCGCGGT 
TCAGGAATCG TCACCCGGCG GCCTCTCATT CTGCAGCTCA TCTTCTCAAA AACAGAACAT 
GCCGAGTTTT TGCACTGCAA GTCCAAAAAG TTTACAGACT TTGATGAAGT CCGGCAGGAG 
ATTGAAGCAG AGACCGACAG GGTCACGGGG ACCAACAAAG GCATCTCCCC AGTGCCCATC 
AACCTTCGAG TCTACTCGCC ACACGTGTTG AACTTGACCC TCATCGACCT CCCGGGTATC 
ACCAAGGTGC CTGTGGGCGA CCAGCCTCCA GACATCGAGT ACCAGATCAA GGACATGATC 
CTGCAGTTCA TCAGCCGGGA GAGCAGCCTC ATTCTGGCTG TCACGCCCGC CAACATGGAC 
CTGGCCAACT CCGACGCCCT CAAGCTGGCC AAGGAAGTCG ATCCCCAAGG CCTACGGACC 
ATCGGTGTCA TCACCAAGCT TGACCTGATG GACGAGGGCA CCGACGCCAG GGACGTCTTG 
GAGAACAAGT TGCTCCCGTT GAGAAGAGGC TACATTGGCG TGGTGAACCG CAGCCAGAAG 
GATATTGAGG GCAAGAAGGA CATCCGTGCA GCACTGGCAG CTGAGAGGAA GTTCTTCCTC 
TCCCACCCGG CCTACCGGCA CATGGCCGAC CGCATGGGCA CGCCACATCT GCAGAAGACG 
CTGAATCAGC AACTGACCAA CCACATCCGG GAGTCGCTGC CGGCCCTACG TAGCAAACTA 
CAGAGCCAGC TGCTGTCCCT GGAGAAGGAG GTGGAGGAGT ACAAGAACTT TCGGCCCGAC 
GACCCCACCC GCAAAACCAA AGCCCTGCTG CAGATGGTCC AGCAGTTTGG GGTGGATTTT 
GAGAAGAGGA TCGAGGGCTC AGGAGATCAG GTGGACACTC TGGAGCTCTC CGGGGGCGCC 
CGAATCAATC GCATCTTCCA CGAGCGGTTC CCATTTGAGC TGGTGAAGAT GGAGTTTGAC 
GAGAAGGACT TACGACGGGA GATCAGCTAT GCCATTAAGA ACATCCATGG AGTCAGGACG 
GGGCTCTTCA CCCCCGACAT GGCCTTTGAA GCCATTGTGA AAAAACAGAT TGTAAAACTC 
AAAGAGCCGA GTTTGAAGTG TGTTGATCTC GTGGTCTCAG AGCTGGCCAC GGTCATAAAA 
AAGTGTGCCG AGAAGCTCAG TTCCTACCCC CGGTTGCGAG AGGAGACAGA GCGAATCGTC 
ACCACTTACA TCCGGGAACG GGAGGGGAGA ACGAAGGACC AGATTCTTCT GCTGATCGAC 
ATTGAGCAGT CCTACATCAA CACGAACCAT GAGGACTTCA TCGGGTTTGC CAATGCCCAG 
CAGAGGAGCA CGCAGCTGAA CAAGAAGAGA GCCATCCCCA ATCAGGGGGA GATCCTGGTG 
ATCCGCAGGG GCTGGCTGAC CATCAACAAC ATCAGCCTGA TGAAAGGCGG CTCCAAGGAG 
TACTGGTTTG TGCTGACTGC CGAGTCACTG TCCTGGTACA AGGATGAGGA GGAGAAAGAG 
AAGAAGTACA TGCTGCCTCT GGACAACCTC AAGATCCGTG ATGTGGAGAA GGGCTTCATG 
TCCAACAAGC ACGTCTTCGC CATCTTCAAC ACGGAGCAGA GAAACGTCTA CAAGGACCTG 
CGGCAGATCG AGCTGGCCTG TGACTCCCAG GAAGACGTGG ACAGCTGGAA GGCCTCGTTC 
CTCCGAGCTG GCGTCTACCC CGAGAAGGAC CAGGCAGAAA ACGAGGATGG GGCCCAGGAG 
AACACCTTCT CCATGGACCC CCAACTGGAG CGGCAGGTGG AGACCATTCG CAACCTGGTG 
GACTCATACG TGGCCATCAT CAACAAGTCC ATCCGCGACC TCATGCCAAA GACCATCATG 
CACCTCATGA TCAACAATAC GAAGGCCTTC ATCCACCACG AGCTGCTGGC CTACCTATAC 
TCCTCGGCAG ACCAGAGCAG CCTCATGGAG GAGTCGGCTG ACCAGGCACA GCGGCGGGAC 
GACATGCTGC GCATGTACCA TGCCCTCAAG GAGGCGCTCA ACATCATCGG TGACATCAGC 
ACCAGCACTG TGTCCACGCC TGTACCCCCG CCTGTCGATG ACACCTGGCT CCAGAGCGCC 
AGCAGCCACA GCCCCACTCC ACAGCGCCGA CCGGTGTCCA GCATACACCC CCCTGGCCGG 
CCCCCAGCAG TGAGGGGCCC CACTCCAGGG CCCCCCCTGA TTCCTGTTCC CGTGGGGGCA 
GCAGCCTCCT TCTCGGCGCC CCCAATCCCA TCCCGGCCTG GACCCCAGAG CGTGTTTGCC 
AACAGTGACC TCTTCCCAGC CCCGCCTCAG ATCCCATCTC GGCCAGTTCG GATCCCCCCA 
GGGATTCCCC CAGGAGTGCC CAGCAGAAGA CCCCCTGCTG CGCCCAGCCG GCCCACCATT 
ATCCGCCCAG CCGAGCCATC CCTGCTCGAC TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNM2 ( NM_001005362.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001005362.1 Homo sapiens dynamin 2 (DNM2), transcript variant 4, mRNA.

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CloneID	OHu22803
Clone ID Related Accession (Same CDS sequence)	NM_001005362.2
Accession Version	NM_001005362.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2601bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-26
Organism	Homo sapiens(human)
Product	dynamin-2 isoform 4
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB069057.1, AC011475.6, AC011552.6, AC112707.2, BC039596.1, AK289831.1 and BU621654.1. On Jun 26, 2010 this sequence version replaced NM_001005362.1. Transcript Variant: This variant (4) lacks two alternate in-frame exons and includes an alternate in-frame exon, compared to variant 1. The resulting protein (isoform 4) is shorter, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.216123.1, SRR1660805.101999.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCAACC GCGGGATGGA AGAGCTGATC CCGCTGGTCA ACAAACTGCA GGACGCCTTC 
AGCTCCATCG GCCAGAGCTG CCACCTGGAC CTGCCGCAGA TCGCTGTAGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTGGAGAAC TTCGTGGGCC GGGACTTCCT TCCCCGCGGT 
TCAGGAATCG TCACCCGGCG GCCTCTCATT CTGCAGCTCA TCTTCTCAAA AACAGAACAT 
GCCGAGTTTT TGCACTGCAA GTCCAAAAAG TTTACAGACT TTGATGAAGT CCGGCAGGAG 
ATTGAAGCAG AGACCGACAG GGTCACGGGG ACCAACAAAG GCATCTCCCC AGTGCCCATC 
AACCTTCGAG TCTACTCGCC ACACGTGTTG AACTTGACCC TCATCGACCT CCCGGGTATC 
ACCAAGGTGC CTGTGGGCGA CCAGCCTCCA GACATCGAGT ACCAGATCAA GGACATGATC 
CTGCAGTTCA TCAGCCGGGA GAGCAGCCTC ATTCTGGCTG TCACGCCCGC CAACATGGAC 
CTGGCCAACT CCGACGCCCT CAAGCTGGCC AAGGAAGTCG ATCCCCAAGG CCTACGGACC 
ATCGGTGTCA TCACCAAGCT TGACCTGATG GACGAGGGCA CCGACGCCAG GGACGTCTTG 
GAGAACAAGT TGCTCCCGTT GAGAAGAGGC TACATTGGCG TGGTGAACCG CAGCCAGAAG 
GATATTGAGG GCAAGAAGGA CATCCGTGCA GCACTGGCAG CTGAGAGGAA GTTCTTCCTC 
TCCCACCCGG CCTACCGGCA CATGGCCGAC CGCATGGGCA CGCCACATCT GCAGAAGACG 
CTGAATCAGC AACTGACCAA CCACATCCGG GAGTCGCTGC CGGCCCTACG TAGCAAACTA 
CAGAGCCAGC TGCTGTCCCT GGAGAAGGAG GTGGAGGAGT ACAAGAACTT TCGGCCCGAC 
GACCCCACCC GCAAAACCAA AGCCCTGCTG CAGATGGTCC AGCAGTTTGG GGTGGATTTT 
GAGAAGAGGA TCGAGGGCTC AGGAGATCAG GTGGACACTC TGGAGCTCTC CGGGGGCGCC 
CGAATCAATC GCATCTTCCA CGAGCGGTTC CCATTTGAGC TGGTGAAGAT GGAGTTTGAC 
GAGAAGGACT TACGACGGGA GATCAGCTAT GCCATTAAGA ACATCCATGG AGTCAGGACG 
GGGCTCTTCA CCCCCGACAT GGCCTTTGAA GCCATTGTGA AAAAACAGAT TGTAAAACTC 
AAAGAGCCGA GTTTGAAGTG TGTTGATCTC GTGGTCTCAG AGCTGGCCAC GGTCATAAAA 
AAGTGTGCCG AGAAGCTCAG TTCCTACCCC CGGTTGCGAG AGGAGACAGA GCGAATCGTC 
ACCACTTACA TCCGGGAACG GGAGGGGAGA ACGAAGGACC AGATTCTTCT GCTGATCGAC 
ATTGAGCAGT CCTACATCAA CACGAACCAT GAGGACTTCA TCGGGTTTGC CAATGCCCAG 
CAGAGGAGCA CGCAGCTGAA CAAGAAGAGA GCCATCCCCA ATCAGGTGAT CCGCAGGGGC 
TGGCTGACCA TCAACAACAT CAGCCTGATG AAAGGCGGCT CCAAGGAGTA CTGGTTTGTG 
CTGACTGCCG AGTCACTGTC CTGGTACAAG GATGAGGAGG AGAAAGAGAA GAAGTACATG 
CTGCCTCTGG ACAACCTCAA GATCCGTGAT GTGGAGAAGG GCTTCATGTC CAACAAGCAC 
GTCTTCGCCA TCTTCAACAC GGAGCAGAGA AACGTCTACA AGGACCTGCG GCAGATCGAG 
CTGGCCTGTG ACTCCCAGGA AGACGTGGAC AGCTGGAAGG CCTCGTTCCT CCGAGCTGGC 
GTCTACCCCG AGAAGGACCA GGCAGAAAAC GAGGATGGGG CCCAGGAGAA CACCTTCTCC 
ATGGACCCCC AACTGGAGCG GCAGGTGGAG ACCATTCGCA ACCTGGTGGA CTCATACGTG 
GCCATCATCA ACAAGTCCAT CCGCGACCTC ATGCCAAAGA CCATCATGCA CCTCATGATC 
AACAATACGA AGGCCTTCAT CCACCACGAG CTGCTGGCCT ACCTATACTC CTCGGCAGAC 
CAGAGCAGCC TCATGGAGGA GTCGGCTGAC CAGGCACAGC GGCGGGACGA CATGCTGCGC 
ATGTACCATG CCCTCAAGGA GGCGCTCAAC ATCATCGGTG ACATCAGCAC CAGCACTGTG 
TCCACGCCTG TACCCCCGCC TGTCGATGAC ACCTGGCTCC AGAGCGCCAG CAGCCACAGC 
CCCACTCCAC AGCGCCGACC GGTGTCCAGC ATACACCCCC CTGGCCGGCC CCCAGCAGTG 
AGGGGCCCCA CTCCAGGGCC CCCCCTGATT CCTGTTCCCG TGGGGGCAGC AGCCTCCTTC 
TCGGCGCCCC CAATCCCATC CCGGCCTGGA CCCCAGAGCG TGTTTGCCAA CAGTGACCTC 
TTCCCAGCCC CGCCTCAGAT CCCATCTCGG CCAGTTCGGA TCCCCCCAGG GATTCCCCCA 
GGAGTGCCCA GCAGAAGACC CCCTGCTGCG CCCAGCCGGC CCACCATTAT CCGCCCAGCC 
GAGCCATCCC TGCTCGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001005362.1
CDS	191..2791
Translation	MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDMAFEAIVKKQIVKLKEPSLKCVDLVVSELATVIKKCAEKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLLD

Target ORF information:

RefSeq Version	NM_001005362.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dynamin 2 (DNM2), transcript variant 4, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001005362.2

ORF Insert Sequence:

ATGGGCAACC GCGGGATGGA AGAGCTGATC CCGCTGGTCA ACAAACTGCA GGACGCCTTC 
AGCTCCATCG GCCAGAGCTG CCACCTGGAC CTGCCGCAGA TCGCTGTAGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTGGAGAAC TTCGTGGGCC GGGACTTCCT TCCCCGCGGT 
TCAGGAATCG TCACCCGGCG GCCTCTCATT CTGCAGCTCA TCTTCTCAAA AACAGAACAT 
GCCGAGTTTT TGCACTGCAA GTCCAAAAAG TTTACAGACT TTGATGAAGT CCGGCAGGAG 
ATTGAAGCAG AGACCGACAG GGTCACGGGG ACCAACAAAG GCATCTCCCC AGTGCCCATC 
AACCTTCGAG TCTACTCGCC ACACGTGTTG AACTTGACCC TCATCGACCT CCCGGGTATC 
ACCAAGGTGC CTGTGGGCGA CCAGCCTCCA GACATCGAGT ACCAGATCAA GGACATGATC 
CTGCAGTTCA TCAGCCGGGA GAGCAGCCTC ATTCTGGCTG TCACGCCCGC CAACATGGAC 
CTGGCCAACT CCGACGCCCT CAAGCTGGCC AAGGAAGTCG ATCCCCAAGG CCTACGGACC 
ATCGGTGTCA TCACCAAGCT TGACCTGATG GACGAGGGCA CCGACGCCAG GGACGTCTTG 
GAGAACAAGT TGCTCCCGTT GAGAAGAGGC TACATTGGCG TGGTGAACCG CAGCCAGAAG 
GATATTGAGG GCAAGAAGGA CATCCGTGCA GCACTGGCAG CTGAGAGGAA GTTCTTCCTC 
TCCCACCCGG CCTACCGGCA CATGGCCGAC CGCATGGGCA CGCCACATCT GCAGAAGACG 
CTGAATCAGC AACTGACCAA CCACATCCGG GAGTCGCTGC CGGCCCTACG TAGCAAACTA 
CAGAGCCAGC TGCTGTCCCT GGAGAAGGAG GTGGAGGAGT ACAAGAACTT TCGGCCCGAC 
GACCCCACCC GCAAAACCAA AGCCCTGCTG CAGATGGTCC AGCAGTTTGG GGTGGATTTT 
GAGAAGAGGA TCGAGGGCTC AGGAGATCAG GTGGACACTC TGGAGCTCTC CGGGGGCGCC 
CGAATCAATC GCATCTTCCA CGAGCGGTTC CCATTTGAGC TGGTGAAGAT GGAGTTTGAC 
GAGAAGGACT TACGACGGGA GATCAGCTAT GCCATTAAGA ACATCCATGG AGTCAGGACG 
GGGCTCTTCA CCCCCGACAT GGCCTTTGAA GCCATTGTGA AAAAACAGAT TGTAAAACTC 
AAAGAGCCGA GTTTGAAGTG TGTTGATCTC GTGGTCTCAG AGCTGGCCAC GGTCATAAAA 
AAGTGTGCCG AGAAGCTCAG TTCCTACCCC CGGTTGCGAG AGGAGACAGA GCGAATCGTC 
ACCACTTACA TCCGGGAACG GGAGGGGAGA ACGAAGGACC AGATTCTTCT GCTGATCGAC 
ATTGAGCAGT CCTACATCAA CACGAACCAT GAGGACTTCA TCGGGTTTGC CAATGCCCAG 
CAGAGGAGCA CGCAGCTGAA CAAGAAGAGA GCCATCCCCA ATCAGGTGAT CCGCAGGGGC 
TGGCTGACCA TCAACAACAT CAGCCTGATG AAAGGCGGCT CCAAGGAGTA CTGGTTTGTG 
CTGACTGCCG AGTCACTGTC CTGGTACAAG GATGAGGAGG AGAAAGAGAA GAAGTACATG 
CTGCCTCTGG ACAACCTCAA GATCCGTGAT GTGGAGAAGG GCTTCATGTC CAACAAGCAC 
GTCTTCGCCA TCTTCAACAC GGAGCAGAGA AACGTCTACA AGGACCTGCG GCAGATCGAG 
CTGGCCTGTG ACTCCCAGGA AGACGTGGAC AGCTGGAAGG CCTCGTTCCT CCGAGCTGGC 
GTCTACCCCG AGAAGGACCA GGCAGAAAAC GAGGATGGGG CCCAGGAGAA CACCTTCTCC 
ATGGACCCCC AACTGGAGCG GCAGGTGGAG ACCATTCGCA ACCTGGTGGA CTCATACGTG 
GCCATCATCA ACAAGTCCAT CCGCGACCTC ATGCCAAAGA CCATCATGCA CCTCATGATC 
AACAATACGA AGGCCTTCAT CCACCACGAG CTGCTGGCCT ACCTATACTC CTCGGCAGAC 
CAGAGCAGCC TCATGGAGGA GTCGGCTGAC CAGGCACAGC GGCGGGACGA CATGCTGCGC 
ATGTACCATG CCCTCAAGGA GGCGCTCAAC ATCATCGGTG ACATCAGCAC CAGCACTGTG 
TCCACGCCTG TACCCCCGCC TGTCGATGAC ACCTGGCTCC AGAGCGCCAG CAGCCACAGC 
CCCACTCCAC AGCGCCGACC GGTGTCCAGC ATACACCCCC CTGGCCGGCC CCCAGCAGTG 
AGGGGCCCCA CTCCAGGGCC CCCCCTGATT CCTGTTCCCG TGGGGGCAGC AGCCTCCTTC 
TCGGCGCCCC CAATCCCATC CCGGCCTGGA CCCCAGAGCG TGTTTGCCAA CAGTGACCTC 
TTCCCAGCCC CGCCTCAGAT CCCATCTCGG CCAGTTCGGA TCCCCCCAGG GATTCCCCCA 
GGAGTGCCCA GCAGAAGACC CCCTGCTGCG CCCAGCCGGC CCACCATTAT CCGCCCAGCC 
GAGCCATCCC TGCTCGACTA G

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNM2 ( NM_001190716.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001177645.1 Homo sapiens dynamin 2 (DNM2), transcript variant 5, mRNA.

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CloneID	OHu27392
Clone ID Related Accession (Same CDS sequence)	NM_001190716.1 , NM_001190716.2
Accession Version	NM_001190716.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2610bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-22
Organism	Homo sapiens(human)
Product	dynamin-2 isoform 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB069057.1, AK312260.1, BC039596.1 and BU621654.1. Transcript Variant: This variant (5) lacks 3 nts at an alternate splice site, compared to variant 1. The resulting protein (isoform 5) lacks one aa in the C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK312260.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGGCAACC GCGGGATGGA AGAGCTGATC CCGCTGGTCA ACAAACTGCA GGACGCCTTC 
AGCTCCATCG GCCAGAGCTG CCACCTGGAC CTGCCGCAGA TCGCTGTAGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTGGAGAAC TTCGTGGGCC GGGACTTCCT TCCCCGCGGT 
TCAGGAATCG TCACCCGGCG GCCTCTCATT CTGCAGCTCA TCTTCTCAAA AACAGAACAT 
GCCGAGTTTT TGCACTGCAA GTCCAAAAAG TTTACAGACT TTGATGAAGT CCGGCAGGAG 
ATTGAAGCAG AGACCGACAG GGTCACGGGG ACCAACAAAG GCATCTCCCC AGTGCCCATC 
AACCTTCGAG TCTACTCGCC ACACGTGTTG AACTTGACCC TCATCGACCT CCCGGGTATC 
ACCAAGGTGC CTGTGGGCGA CCAGCCTCCA GACATCGAGT ACCAGATCAA GGACATGATC 
CTGCAGTTCA TCAGCCGGGA GAGCAGCCTC ATTCTGGCTG TCACGCCCGC CAACATGGAC 
CTGGCCAACT CCGACGCCCT CAAGCTGGCC AAGGAAGTCG ATCCCCAAGG CCTACGGACC 
ATCGGTGTCA TCACCAAGCT TGACCTGATG GACGAGGGCA CCGACGCCAG GGACGTCTTG 
GAGAACAAGT TGCTCCCGTT GAGAAGAGGC TACATTGGCG TGGTGAACCG CAGCCAGAAG 
GATATTGAGG GCAAGAAGGA CATCCGTGCA GCACTGGCAG CTGAGAGGAA GTTCTTCCTC 
TCCCACCCGG CCTACCGGCA CATGGCCGAC CGCATGGGCA CGCCACATCT GCAGAAGACG 
CTGAATCAGC AACTGACCAA CCACATCCGG GAGTCGCTGC CGGCCCTACG TAGCAAACTA 
CAGAGCCAGC TGCTGTCCCT GGAGAAGGAG GTGGAGGAGT ACAAGAACTT TCGGCCCGAC 
GACCCCACCC GCAAAACCAA AGCCCTGCTG CAGATGGTCC AGCAGTTTGG GGTGGATTTT 
GAGAAGAGGA TCGAGGGCTC AGGAGATCAG GTGGACACTC TGGAGCTCTC CGGGGGCGCC 
CGAATCAATC GCATCTTCCA CGAGCGGTTC CCATTTGAGC TGGTGAAGAT GGAGTTTGAC 
GAGAAGGACT TACGACGGGA GATCAGCTAT GCCATTAAGA ACATCCATGG AGTCAGGACC 
GGGCTTTTCA CCCCGGACTT GGCATTCGAG GCCATTGTGA AAAAGCAGGT CGTCAAGCTG 
AAAGAGCCCT GTCTGAAATG TGTCGACCTG GTTATCCAGG AGCTAATCAA TACAGTTAGG 
CAGTGTACCA GTAAGCTCAG TTCCTACCCC CGGTTGCGAG AGGAGACAGA GCGAATCGTC 
ACCACTTACA TCCGGGAACG GGAGGGGAGA ACGAAGGACC AGATTCTTCT GCTGATCGAC 
ATTGAGCAGT CCTACATCAA CACGAACCAT GAGGACTTCA TCGGGTTTGC CAATGCCCAG 
CAGAGGAGCA CGCAGCTGAA CAAGAAGAGA GCCATCCCCA ATCAGGGGGA GATCCTGGTG 
ATCCGCAGGG GCTGGCTGAC CATCAACAAC ATCAGCCTGA TGAAAGGCGG CTCCAAGGAG 
TACTGGTTTG TGCTGACTGC CGAGTCACTG TCCTGGTACA AGGATGAGGA GGAGAAAGAG 
AAGAAGTACA TGCTGCCTCT GGACAACCTC AAGATCCGTG ATGTGGAGAA GGGCTTCATG 
TCCAACAAGC ACGTCTTCGC CATCTTCAAC ACGGAGCAGA GAAACGTCTA CAAGGACCTG 
CGGCAGATCG AGCTGGCCTG TGACTCCCAG GAAGACGTGG ACAGCTGGAA GGCCTCGTTC 
CTCCGAGCTG GCGTCTACCC CGAGAAGGAC CAGGCAGAAA ACGAGGATGG GGCCCAGGAG 
AACACCTTCT CCATGGACCC CCAACTGGAG CGGCAGGTGG AGACCATTCG CAACCTGGTG 
GACTCATACG TGGCCATCAT CAACAAGTCC ATCCGCGACC TCATGCCAAA GACCATCATG 
CACCTCATGA TCAACAATAC GAAGGCCTTC ATCCACCACG AGCTGCTGGC CTACCTATAC 
TCCTCGGCAG ACCAGAGCAG CCTCATGGAG GAGTCGGCTG ACCAGGCACA GCGGCGGGAC 
GACATGCTGC GCATGTACCA TGCCCTCAAG GAGGCGCTCA ACATCATCGG TGACATCAGC 
ACCAGCACTG TGTCCACGCC TGTACCCCCG CCTGTCGATG ACACCTGGCT CCAGAGCGCC 
AGCAGCCACA GCCCCACTCC ACAGCGCCGA CCGGTGTCCA GCATACACCC CCCTGGCCGG 
CCCCCAGCAG TGAGGGGCCC CACTCCAGGG CCCCCCCTGA TTCCTGTTCC CGTGGGGGCA 
GCAGCCTCCT TCTCGGCGCC CCCAATCCCA TCCCGGCCTG GACCCCAGAG CGTGTTTGCC 
AACAGTGACC TCTTCCCAGC CCCGCCTCAG ATCCCATCTC GGCCAGTTCG GATCCCCCCA 
GGGATTCCCC CAGGAGTGCC CAGAAGACCC CCTGCTGCGC CCAGCCGGCC CACCATTATC 
CGCCCAGCCG AGCCATCCCT GCTCGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001177645.1
CDS	191..2800
Translation	MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPRRPPAAPSRPTIIRPAEPSLLD

Target ORF information:

RefSeq Version	NM_001190716.1
Organism	Homo sapiens(human)
Definition	Homo sapiens dynamin 2 (DNM2), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001190716.1

ORF Insert Sequence:

ATGGGCAACC GCGGGATGGA AGAGCTGATC CCGCTGGTCA ACAAACTGCA GGACGCCTTC 
AGCTCCATCG GCCAGAGCTG CCACCTGGAC CTGCCGCAGA TCGCTGTAGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTGGAGAAC TTCGTGGGCC GGGACTTCCT TCCCCGCGGT 
TCAGGAATCG TCACCCGGCG GCCTCTCATT CTGCAGCTCA TCTTCTCAAA AACAGAACAT 
GCCGAGTTTT TGCACTGCAA GTCCAAAAAG TTTACAGACT TTGATGAAGT CCGGCAGGAG 
ATTGAAGCAG AGACCGACAG GGTCACGGGG ACCAACAAAG GCATCTCCCC AGTGCCCATC 
AACCTTCGAG TCTACTCGCC ACACGTGTTG AACTTGACCC TCATCGACCT CCCGGGTATC 
ACCAAGGTGC CTGTGGGCGA CCAGCCTCCA GACATCGAGT ACCAGATCAA GGACATGATC 
CTGCAGTTCA TCAGCCGGGA GAGCAGCCTC ATTCTGGCTG TCACGCCCGC CAACATGGAC 
CTGGCCAACT CCGACGCCCT CAAGCTGGCC AAGGAAGTCG ATCCCCAAGG CCTACGGACC 
ATCGGTGTCA TCACCAAGCT TGACCTGATG GACGAGGGCA CCGACGCCAG GGACGTCTTG 
GAGAACAAGT TGCTCCCGTT GAGAAGAGGC TACATTGGCG TGGTGAACCG CAGCCAGAAG 
GATATTGAGG GCAAGAAGGA CATCCGTGCA GCACTGGCAG CTGAGAGGAA GTTCTTCCTC 
TCCCACCCGG CCTACCGGCA CATGGCCGAC CGCATGGGCA CGCCACATCT GCAGAAGACG 
CTGAATCAGC AACTGACCAA CCACATCCGG GAGTCGCTGC CGGCCCTACG TAGCAAACTA 
CAGAGCCAGC TGCTGTCCCT GGAGAAGGAG GTGGAGGAGT ACAAGAACTT TCGGCCCGAC 
GACCCCACCC GCAAAACCAA AGCCCTGCTG CAGATGGTCC AGCAGTTTGG GGTGGATTTT 
GAGAAGAGGA TCGAGGGCTC AGGAGATCAG GTGGACACTC TGGAGCTCTC CGGGGGCGCC 
CGAATCAATC GCATCTTCCA CGAGCGGTTC CCATTTGAGC TGGTGAAGAT GGAGTTTGAC 
GAGAAGGACT TACGACGGGA GATCAGCTAT GCCATTAAGA ACATCCATGG AGTCAGGACC 
GGGCTTTTCA CCCCGGACTT GGCATTCGAG GCCATTGTGA AAAAGCAGGT CGTCAAGCTG 
AAAGAGCCCT GTCTGAAATG TGTCGACCTG GTTATCCAGG AGCTAATCAA TACAGTTAGG 
CAGTGTACCA GTAAGCTCAG TTCCTACCCC CGGTTGCGAG AGGAGACAGA GCGAATCGTC 
ACCACTTACA TCCGGGAACG GGAGGGGAGA ACGAAGGACC AGATTCTTCT GCTGATCGAC 
ATTGAGCAGT CCTACATCAA CACGAACCAT GAGGACTTCA TCGGGTTTGC CAATGCCCAG 
CAGAGGAGCA CGCAGCTGAA CAAGAAGAGA GCCATCCCCA ATCAGGGGGA GATCCTGGTG 
ATCCGCAGGG GCTGGCTGAC CATCAACAAC ATCAGCCTGA TGAAAGGCGG CTCCAAGGAG 
TACTGGTTTG TGCTGACTGC CGAGTCACTG TCCTGGTACA AGGATGAGGA GGAGAAAGAG 
AAGAAGTACA TGCTGCCTCT GGACAACCTC AAGATCCGTG ATGTGGAGAA GGGCTTCATG 
TCCAACAAGC ACGTCTTCGC CATCTTCAAC ACGGAGCAGA GAAACGTCTA CAAGGACCTG 
CGGCAGATCG AGCTGGCCTG TGACTCCCAG GAAGACGTGG ACAGCTGGAA GGCCTCGTTC 
CTCCGAGCTG GCGTCTACCC CGAGAAGGAC CAGGCAGAAA ACGAGGATGG GGCCCAGGAG 
AACACCTTCT CCATGGACCC CCAACTGGAG CGGCAGGTGG AGACCATTCG CAACCTGGTG 
GACTCATACG TGGCCATCAT CAACAAGTCC ATCCGCGACC TCATGCCAAA GACCATCATG 
CACCTCATGA TCAACAATAC GAAGGCCTTC ATCCACCACG AGCTGCTGGC CTACCTATAC 
TCCTCGGCAG ACCAGAGCAG CCTCATGGAG GAGTCGGCTG ACCAGGCACA GCGGCGGGAC 
GACATGCTGC GCATGTACCA TGCCCTCAAG GAGGCGCTCA ACATCATCGG TGACATCAGC 
ACCAGCACTG TGTCCACGCC TGTACCCCCG CCTGTCGATG ACACCTGGCT CCAGAGCGCC 
AGCAGCCACA GCCCCACTCC ACAGCGCCGA CCGGTGTCCA GCATACACCC CCCTGGCCGG 
CCCCCAGCAG TGAGGGGCCC CACTCCAGGG CCCCCCCTGA TTCCTGTTCC CGTGGGGGCA 
GCAGCCTCCT TCTCGGCGCC CCCAATCCCA TCCCGGCCTG GACCCCAGAG CGTGTTTGCC 
AACAGTGACC TCTTCCCAGC CCCGCCTCAG ATCCCATCTC GGCCAGTTCG GATCCCCCCA 
GGGATTCCCC CAGGAGTGCC CAGAAGACCC CCTGCTGCGC CCAGCCGGCC CACCATTATC 
CGCCCAGCCG AGCCATCCCT GCTCGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNM2 ( NM_001190716.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001177645.1 Homo sapiens dynamin 2 (DNM2), transcript variant 5, mRNA.

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CloneID	OHu27392
Clone ID Related Accession (Same CDS sequence)	NM_001190716.1 , NM_001190716.2
Accession Version	NM_001190716.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2610bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	dynamin-2 isoform 5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AK312260.1, BC039596.1 and BU621654.1. On Jun 2, 2019 this sequence version replaced NM_001190716.1. Transcript Variant: This variant (5) lacks 3 nts at an alternate splice site, compared to variant 1. The resulting protein (isoform 5) lacks one aa in the C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK312260.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END##

ATGGGCAACC GCGGGATGGA AGAGCTGATC CCGCTGGTCA ACAAACTGCA GGACGCCTTC 
AGCTCCATCG GCCAGAGCTG CCACCTGGAC CTGCCGCAGA TCGCTGTAGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTGGAGAAC TTCGTGGGCC GGGACTTCCT TCCCCGCGGT 
TCAGGAATCG TCACCCGGCG GCCTCTCATT CTGCAGCTCA TCTTCTCAAA AACAGAACAT 
GCCGAGTTTT TGCACTGCAA GTCCAAAAAG TTTACAGACT TTGATGAAGT CCGGCAGGAG 
ATTGAAGCAG AGACCGACAG GGTCACGGGG ACCAACAAAG GCATCTCCCC AGTGCCCATC 
AACCTTCGAG TCTACTCGCC ACACGTGTTG AACTTGACCC TCATCGACCT CCCGGGTATC 
ACCAAGGTGC CTGTGGGCGA CCAGCCTCCA GACATCGAGT ACCAGATCAA GGACATGATC 
CTGCAGTTCA TCAGCCGGGA GAGCAGCCTC ATTCTGGCTG TCACGCCCGC CAACATGGAC 
CTGGCCAACT CCGACGCCCT CAAGCTGGCC AAGGAAGTCG ATCCCCAAGG CCTACGGACC 
ATCGGTGTCA TCACCAAGCT TGACCTGATG GACGAGGGCA CCGACGCCAG GGACGTCTTG 
GAGAACAAGT TGCTCCCGTT GAGAAGAGGC TACATTGGCG TGGTGAACCG CAGCCAGAAG 
GATATTGAGG GCAAGAAGGA CATCCGTGCA GCACTGGCAG CTGAGAGGAA GTTCTTCCTC 
TCCCACCCGG CCTACCGGCA CATGGCCGAC CGCATGGGCA CGCCACATCT GCAGAAGACG 
CTGAATCAGC AACTGACCAA CCACATCCGG GAGTCGCTGC CGGCCCTACG TAGCAAACTA 
CAGAGCCAGC TGCTGTCCCT GGAGAAGGAG GTGGAGGAGT ACAAGAACTT TCGGCCCGAC 
GACCCCACCC GCAAAACCAA AGCCCTGCTG CAGATGGTCC AGCAGTTTGG GGTGGATTTT 
GAGAAGAGGA TCGAGGGCTC AGGAGATCAG GTGGACACTC TGGAGCTCTC CGGGGGCGCC 
CGAATCAATC GCATCTTCCA CGAGCGGTTC CCATTTGAGC TGGTGAAGAT GGAGTTTGAC 
GAGAAGGACT TACGACGGGA GATCAGCTAT GCCATTAAGA ACATCCATGG AGTCAGGACC 
GGGCTTTTCA CCCCGGACTT GGCATTCGAG GCCATTGTGA AAAAGCAGGT CGTCAAGCTG 
AAAGAGCCCT GTCTGAAATG TGTCGACCTG GTTATCCAGG AGCTAATCAA TACAGTTAGG 
CAGTGTACCA GTAAGCTCAG TTCCTACCCC CGGTTGCGAG AGGAGACAGA GCGAATCGTC 
ACCACTTACA TCCGGGAACG GGAGGGGAGA ACGAAGGACC AGATTCTTCT GCTGATCGAC 
ATTGAGCAGT CCTACATCAA CACGAACCAT GAGGACTTCA TCGGGTTTGC CAATGCCCAG 
CAGAGGAGCA CGCAGCTGAA CAAGAAGAGA GCCATCCCCA ATCAGGGGGA GATCCTGGTG 
ATCCGCAGGG GCTGGCTGAC CATCAACAAC ATCAGCCTGA TGAAAGGCGG CTCCAAGGAG 
TACTGGTTTG TGCTGACTGC CGAGTCACTG TCCTGGTACA AGGATGAGGA GGAGAAAGAG 
AAGAAGTACA TGCTGCCTCT GGACAACCTC AAGATCCGTG ATGTGGAGAA GGGCTTCATG 
TCCAACAAGC ACGTCTTCGC CATCTTCAAC ACGGAGCAGA GAAACGTCTA CAAGGACCTG 
CGGCAGATCG AGCTGGCCTG TGACTCCCAG GAAGACGTGG ACAGCTGGAA GGCCTCGTTC 
CTCCGAGCTG GCGTCTACCC CGAGAAGGAC CAGGCAGAAA ACGAGGATGG GGCCCAGGAG 
AACACCTTCT CCATGGACCC CCAACTGGAG CGGCAGGTGG AGACCATTCG CAACCTGGTG 
GACTCATACG TGGCCATCAT CAACAAGTCC ATCCGCGACC TCATGCCAAA GACCATCATG 
CACCTCATGA TCAACAATAC GAAGGCCTTC ATCCACCACG AGCTGCTGGC CTACCTATAC 
TCCTCGGCAG ACCAGAGCAG CCTCATGGAG GAGTCGGCTG ACCAGGCACA GCGGCGGGAC 
GACATGCTGC GCATGTACCA TGCCCTCAAG GAGGCGCTCA ACATCATCGG TGACATCAGC 
ACCAGCACTG TGTCCACGCC TGTACCCCCG CCTGTCGATG ACACCTGGCT CCAGAGCGCC 
AGCAGCCACA GCCCCACTCC ACAGCGCCGA CCGGTGTCCA GCATACACCC CCCTGGCCGG 
CCCCCAGCAG TGAGGGGCCC CACTCCAGGG CCCCCCCTGA TTCCTGTTCC CGTGGGGGCA 
GCAGCCTCCT TCTCGGCGCC CCCAATCCCA TCCCGGCCTG GACCCCAGAG CGTGTTTGCC 
AACAGTGACC TCTTCCCAGC CCCGCCTCAG ATCCCATCTC GGCCAGTTCG GATCCCCCCA 
GGGATTCCCC CAGGAGTGCC CAGAAGACCC CCTGCTGCGC CCAGCCGGCC CACCATTATC 
CGCCCAGCCG AGCCATCCCT GCTCGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001177645.1
CDS	165..2774
Translation	MGNRGMEELIPLVNKLQDAFSSIGQSCHLDLPQIAVVGGQSAGKSSVLENFVGRDFLPRGSGIVTRRPLILQLIFSKTEHAEFLHCKSKKFTDFDEVRQEIEAETDRVTGTNKGISPVPINLRVYSPHVLNLTLIDLPGITKVPVGDQPPDIEYQIKDMILQFISRESSLILAVTPANMDLANSDALKLAKEVDPQGLRTIGVITKLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIEGKKDIRAALAAERKFFLSHPAYRHMADRMGTPHLQKTLNQQLTNHIRESLPALRSKLQSQLLSLEKEVEEYKNFRPDDPTRKTKALLQMVQQFGVDFEKRIEGSGDQVDTLELSGGARINRIFHERFPFELVKMEFDEKDLRREISYAIKNIHGVRTGLFTPDLAFEAIVKKQVVKLKEPCLKCVDLVIQELINTVRQCTSKLSSYPRLREETERIVTTYIREREGRTKDQILLLIDIEQSYINTNHEDFIGFANAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPRRPPAAPSRPTIIRPAEPSLLD

Target ORF information:

RefSeq Version	NM_001190716.2
Organism	Homo sapiens(human)
Definition	Homo sapiens dynamin 2 (DNM2), transcript variant 5, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001190716.2

ORF Insert Sequence:

ATGGGCAACC GCGGGATGGA AGAGCTGATC CCGCTGGTCA ACAAACTGCA GGACGCCTTC 
AGCTCCATCG GCCAGAGCTG CCACCTGGAC CTGCCGCAGA TCGCTGTAGT GGGCGGCCAG 
AGCGCCGGCA AGAGCTCGGT GCTGGAGAAC TTCGTGGGCC GGGACTTCCT TCCCCGCGGT 
TCAGGAATCG TCACCCGGCG GCCTCTCATT CTGCAGCTCA TCTTCTCAAA AACAGAACAT 
GCCGAGTTTT TGCACTGCAA GTCCAAAAAG TTTACAGACT TTGATGAAGT CCGGCAGGAG 
ATTGAAGCAG AGACCGACAG GGTCACGGGG ACCAACAAAG GCATCTCCCC AGTGCCCATC 
AACCTTCGAG TCTACTCGCC ACACGTGTTG AACTTGACCC TCATCGACCT CCCGGGTATC 
ACCAAGGTGC CTGTGGGCGA CCAGCCTCCA GACATCGAGT ACCAGATCAA GGACATGATC 
CTGCAGTTCA TCAGCCGGGA GAGCAGCCTC ATTCTGGCTG TCACGCCCGC CAACATGGAC 
CTGGCCAACT CCGACGCCCT CAAGCTGGCC AAGGAAGTCG ATCCCCAAGG CCTACGGACC 
ATCGGTGTCA TCACCAAGCT TGACCTGATG GACGAGGGCA CCGACGCCAG GGACGTCTTG 
GAGAACAAGT TGCTCCCGTT GAGAAGAGGC TACATTGGCG TGGTGAACCG CAGCCAGAAG 
GATATTGAGG GCAAGAAGGA CATCCGTGCA GCACTGGCAG CTGAGAGGAA GTTCTTCCTC 
TCCCACCCGG CCTACCGGCA CATGGCCGAC CGCATGGGCA CGCCACATCT GCAGAAGACG 
CTGAATCAGC AACTGACCAA CCACATCCGG GAGTCGCTGC CGGCCCTACG TAGCAAACTA 
CAGAGCCAGC TGCTGTCCCT GGAGAAGGAG GTGGAGGAGT ACAAGAACTT TCGGCCCGAC 
GACCCCACCC GCAAAACCAA AGCCCTGCTG CAGATGGTCC AGCAGTTTGG GGTGGATTTT 
GAGAAGAGGA TCGAGGGCTC AGGAGATCAG GTGGACACTC TGGAGCTCTC CGGGGGCGCC 
CGAATCAATC GCATCTTCCA CGAGCGGTTC CCATTTGAGC TGGTGAAGAT GGAGTTTGAC 
GAGAAGGACT TACGACGGGA GATCAGCTAT GCCATTAAGA ACATCCATGG AGTCAGGACC 
GGGCTTTTCA CCCCGGACTT GGCATTCGAG GCCATTGTGA AAAAGCAGGT CGTCAAGCTG 
AAAGAGCCCT GTCTGAAATG TGTCGACCTG GTTATCCAGG AGCTAATCAA TACAGTTAGG 
CAGTGTACCA GTAAGCTCAG TTCCTACCCC CGGTTGCGAG AGGAGACAGA GCGAATCGTC 
ACCACTTACA TCCGGGAACG GGAGGGGAGA ACGAAGGACC AGATTCTTCT GCTGATCGAC 
ATTGAGCAGT CCTACATCAA CACGAACCAT GAGGACTTCA TCGGGTTTGC CAATGCCCAG 
CAGAGGAGCA CGCAGCTGAA CAAGAAGAGA GCCATCCCCA ATCAGGGGGA GATCCTGGTG 
ATCCGCAGGG GCTGGCTGAC CATCAACAAC ATCAGCCTGA TGAAAGGCGG CTCCAAGGAG 
TACTGGTTTG TGCTGACTGC CGAGTCACTG TCCTGGTACA AGGATGAGGA GGAGAAAGAG 
AAGAAGTACA TGCTGCCTCT GGACAACCTC AAGATCCGTG ATGTGGAGAA GGGCTTCATG 
TCCAACAAGC ACGTCTTCGC CATCTTCAAC ACGGAGCAGA GAAACGTCTA CAAGGACCTG 
CGGCAGATCG AGCTGGCCTG TGACTCCCAG GAAGACGTGG ACAGCTGGAA GGCCTCGTTC 
CTCCGAGCTG GCGTCTACCC CGAGAAGGAC CAGGCAGAAA ACGAGGATGG GGCCCAGGAG 
AACACCTTCT CCATGGACCC CCAACTGGAG CGGCAGGTGG AGACCATTCG CAACCTGGTG 
GACTCATACG TGGCCATCAT CAACAAGTCC ATCCGCGACC TCATGCCAAA GACCATCATG 
CACCTCATGA TCAACAATAC GAAGGCCTTC ATCCACCACG AGCTGCTGGC CTACCTATAC 
TCCTCGGCAG ACCAGAGCAG CCTCATGGAG GAGTCGGCTG ACCAGGCACA GCGGCGGGAC 
GACATGCTGC GCATGTACCA TGCCCTCAAG GAGGCGCTCA ACATCATCGG TGACATCAGC 
ACCAGCACTG TGTCCACGCC TGTACCCCCG CCTGTCGATG ACACCTGGCT CCAGAGCGCC 
AGCAGCCACA GCCCCACTCC ACAGCGCCGA CCGGTGTCCA GCATACACCC CCCTGGCCGG 
CCCCCAGCAG TGAGGGGCCC CACTCCAGGG CCCCCCCTGA TTCCTGTTCC CGTGGGGGCA 
GCAGCCTCCT TCTCGGCGCC CCCAATCCCA TCCCGGCCTG GACCCCAGAG CGTGTTTGCC 
AACAGTGACC TCTTCCCAGC CCCGCCTCAG ATCCCATCTC GGCCAGTTCG GATCCCCCCA 
GGGATTCCCC CAGGAGTGCC CAGAAGACCC CCTGCTGCGC CCAGCCGGCC CACCATTATC 
CGCCCAGCCG AGCCATCCCT GCTCGACTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Characterization of a novel role for the dynamin mechanoenzymes in the regulation of human sperm acrosomal exocytosis.
Molecular human reproduction23(10)657-673(2017 Oct)
Zhou W,Anderson AL,Turner AP,De Iuliis GN,McCluskey A,McLaughlin EA,Nixon B

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DNM2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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