DNASE1L2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DNASE1L2
Entrez Gene ID	1775
Full Name	deoxyribonuclease 1 like 2
Synonyms	DNAS1L2
General protein information	Preferred Names deoxyribonuclease 1 like 2 Names deoxyribonuclease-1-like 2 DNase I homolog protein DHP1 DNase I-like 2 deoxyribonuclease I-like 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 16 Map Location: 16p13.3
Disorder MIM:	602622

mRNA and Protein(s)

mRNA	Protein	Name
XM_011522399.1	XP_011520701.1	deoxyribonuclease-1-like 2 isoform X1
NM_001301680.2	NP_001288609.1	deoxyribonuclease-1-like 2 precursor
NM_001374.3	NP_001365.1	deoxyribonuclease-1-like 2 precursor
NM_001374.2	NP_001365.1	deoxyribonuclease-1-like 2 precursor
XM_011522399.2	XP_011520701.1	deoxyribonuclease-1-like 2 isoform X1
NM_001301680.1	NP_001288609.1	deoxyribonuclease-1-like 2 precursor

Pathways from BioSystems

Homologies

Bos taurus (cattle)	DNASE1L2	NP_001098489.1
Rattus norvegicus (Norway rat)	Dnase1l2	XP_001057412.4
Pan troglodytes (chimpanzee)	DNASE1L2	XP_003952812.1
Homo sapiens (human)	DNASE1L2	NP_001365.1
Mus musculus (house mouse)	Dnase1l2	NP_079994.2

Gene Ontology
Bibliography

Related articles in PubMed

Survey of single-nucleotide polymorphisms in the gene encoding human deoxyribonuclease I-like 2 producing loss of function potentially implicated in the pathogenesis of parakeratosis.
Ueki M, Takeshita H, Utsunomiya N, Chino T, Oyama N, Hasegawa M, Kimura-Kataoka K, Fujihara J, Iida R, Yasuda T
PloS one12(4)e0175083(2017)

Identification of functional SNPs potentially served as a genetic risk factor for the pathogenesis of parakeratosis in the gene encoding human deoxyribonuclease I-like 2 (DNase 1L2) implicated in terminal differentiation of keratinocytes.
Ueki M, Takeshita H, Kimura-Kataoka K, Fujihara J, Iida R, Yasuda T
Gene561(1)15-22(2015 Apr)

Five non-synonymous SNPs in the gene encoding human deoxyribonuclease I-like 2 implicated in terminal differentiation of keratinocytes reduce or abolish its activity.
Ueki M, Fujihara J, Kimura-Kataoka K, Takeshita H, Iida R, Yasuda T
Electrophoresis34(3)456-62(2013 Feb)

Global analysis of single nucleotide polymorphisms in the exons of human deoxyribonuclease I-like 1 and 2 genes.
Fujihara J, Yasuda T, Iida R, Kimura-Kataoka K, Soejima M, Koda Y, Kato H, Panduro A, Yuasa I, Takeshita H
Electrophoresis31(21)3552-7(2010 Oct)

Genetic and expression analysis of all non-synonymous single nucleotide polymorphisms in the human deoxyribonuclease I-like 1 and 2 genes.
Ueki M, Fujihara J, Takeshita H, Kimura-Kataoka K, Iida R, Nakajima T, Kominato Y, Yuasa I, Yasuda T
Electrophoresis31(12)2063-9(2010 Jun)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Study surveyed the non-synonymous SNPs of DNASE1L2: 19 SNPs originating from frameshift/nonsense mutations found in DNASE1L2 resulted in loss of function of the enzyme. Thus, the present findings suggest that each of the minor alleles for these SNPs may serve as one of genetic risk factors for parakeratotic skin diseases such as psoriasis, even though they lack a worldwide genetic distribution.
Title: Survey of single-nucleotide polymorphisms in the gene encoding human deoxyribonuclease I-like 2 producing loss of function potentially implicated in the pathogenesis of parakeratosis.

DNASE1L2 is generally well conserved with regard to the non-synonymous single nucleotide polymorphisms, thereby avoiding any marked reduction of the enzyme activity in human populations.
Title: Identification of functional SNPs potentially served as a genetic risk factor for the pathogenesis of parakeratosis in the gene encoding human deoxyribonuclease I-like 2 (DNase 1L2) implicated in terminal differentiation of keratinocytes.

Genotyping of 17 SNPs in the human deoxyribonuclease I-like 2 gene was performed using the PCR-RFLP method in three ethnic groups including 14 different populations.
Title: Five non-synonymous SNPs in the gene encoding human deoxyribonuclease I-like 2 implicated in terminal differentiation of keratinocytes reduce or abolish its activity.

Several SNPs in the deoxyribonuclease I-like 1 (DNase 1L1) and DNase 1L2 were investigated.
Title: Global analysis of single nucleotide polymorphisms in the exons of human deoxyribonuclease I-like 1 and 2 genes.

Genotyping of all the non-synonymous SNPs of was performed in three ethnic groups including six different populations using the PCR-RFLP method newly developed.
Title: Genetic and expression analysis of all non-synonymous single nucleotide polymorphisms in the human deoxyribonuclease I-like 1 and 2 genes.

The following DNASE1L2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DNASE1L2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02910	NM_001374.3 Latest version!	Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu02910	NM_001301680.2 Latest version!	Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu57330	XM_011522399.2 Latest version!	Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu02910	NM_001374.2	Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
OHu57330	XM_011522399.1	Homo sapiens deoxyribonuclease I-like 2 (DNASE1L2), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
OHu02910	NM_001301680.1	Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DNASE1L2 ( NM_001374.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001365.1 Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02910
Clone ID Related Accession (Same CDS sequence)	NM_001301680.2 , NM_001374.3 , NM_001374.2 , NM_001301680.1
Accession Version	NM_001374.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-04-30
Organism	Homo sapiens(human)
Product	deoxyribonuclease-1-like 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009065.8 and BC063710.1. On Nov 22, 2018 this sequence version replaced NM_001374.2. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063710.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000320700.10/ ENSP00000316938.5 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGCGGGC CCCGGGCTCT GCTGGCCGCA CTCTGGGCGC TGGAAGCCGC CGGGACCGCC 
GCGCTTCGCA TCGGAGCCTT CAACATTCAG AGCTTCGGTG ACAGCAAAGT GTCGGACCCC 
GCTTGCGGCA GCATCATCGC GAAGATCCTG GCTGGCTATG ACCTCGCGCT GGTGCAGGAG 
GTGCGAGACC CAGACCTCAG CGCCGTGTCC GCGCTCATGG AGCAGATCAA CAGCGTGTCC 
GAGCACGAGT ACAGCTTTGT GAGCAGCCAG CCCCTGGGCC GGGACCAGTA CAAGGAGATG 
TACCTGTTCG TGTACAGGAA AGACGCGGTG TCGGTCGTGG ACACCTACCT GTACCCAGAC 
CCCGAGGACG TCTTCAGCCG CGAGCCCTTC GTGGTCAAGT TCTCGGCCCC CGGCACCGGT 
GAGCGGGCCC CGCCCCTCCC CTCCCGCCGA GCTCTGACGC CCCCACCCCT TCCCGCAGCA 
GCACAGAACC TGGTGCTGAT CCCGCTGCAC GCGGCGCCGC ATCAAGCCGT GGCGGAGATC 
GACGCGCTCT ACGACGTGTA CCTGGACGTG ATCGACAAGT GGGGCACCGA CGACATGCTG 
TTCCTGGGCG ACTTCAACGC CGACTGCAGC TATGTGCGGG CGCAGGACTG GGCCGCCATC 
CGTCTGAGGA GCAGTGAGGT CTTCAAGTGG CTCATCCCTG ACAGCGCCGA CACCACGGTG 
GGCAACTCAG ACTGCGCCTA CGACCGCATT GTGGCCTGTG GCGCCCGCCT GCGCCGGAGC 
CTGAAGCCCC AGTCGGCCAC CGTGCACGAC TTCCAGGAGG AATTCGGCCT GGACCAGACT 
CAGGCTCTTG CCATCAGCGA CCACTTTCCA GTGGAGGTGA CCCTCAAGTT CCACCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001365.1
CDS	157..1056
Translation	MGGPRALLAALWALEAAGTAALRIGAFNIQSFGDSKVSDPACGSIIAKILAGYDLALVQEVRDPDLSAVSALMEQINSVSEHEYSFVSSQPLGRDQYKEMYLFVYRKDAVSVVDTYLYPDPEDVFSREPFVVKFSAPGTGERAPPLPSRRALTPPPLPAAAQNLVLIPLHAAPHQAVAEIDALYDVYLDVIDKWGTDDMLFLGDFNADCSYVRAQDWAAIRLRSSEVFKWLIPDSADTTVGNSDCAYDRIVACGARLRRSLKPQSATVHDFQEEFGLDQTQALAISDHFPVEVTLKFHR

Target ORF information:

RefSeq Version	NM_001374.3
Organism	Homo sapiens(human)
Definition	Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001374.3

ORF Insert Sequence:

ATGGGCGGGC CCCGGGCTCT GCTGGCCGCA CTCTGGGCGC TGGAAGCCGC CGGGACCGCC 
GCGCTTCGCA TCGGAGCCTT CAACATTCAG AGCTTCGGTG ACAGCAAAGT GTCGGACCCC 
GCTTGCGGCA GCATCATCGC GAAGATCCTG GCTGGCTATG ACCTCGCGCT GGTGCAGGAG 
GTGCGAGACC CAGACCTCAG CGCCGTGTCC GCGCTCATGG AGCAGATCAA CAGCGTGTCC 
GAGCACGAGT ACAGCTTTGT GAGCAGCCAG CCCCTGGGCC GGGACCAGTA CAAGGAGATG 
TACCTGTTCG TGTACAGGAA AGACGCGGTG TCGGTCGTGG ACACCTACCT GTACCCAGAC 
CCCGAGGACG TCTTCAGCCG CGAGCCCTTC GTGGTCAAGT TCTCGGCCCC CGGCACCGGT 
GAGCGGGCCC CGCCCCTCCC CTCCCGCCGA GCTCTGACGC CCCCACCCCT TCCCGCAGCA 
GCACAGAACC TGGTGCTGAT CCCGCTGCAC GCGGCGCCGC ATCAAGCCGT GGCGGAGATC 
GACGCGCTCT ACGACGTGTA CCTGGACGTG ATCGACAAGT GGGGCACCGA CGACATGCTG 
TTCCTGGGCG ACTTCAACGC CGACTGCAGC TATGTGCGGG CGCAGGACTG GGCCGCCATC 
CGTCTGAGGA GCAGTGAGGT CTTCAAGTGG CTCATCCCTG ACAGCGCCGA CACCACGGTG 
GGCAACTCAG ACTGCGCCTA CGACCGCATT GTGGCCTGTG GCGCCCGCCT GCGCCGGAGC 
CTGAAGCCCC AGTCGGCCAC CGTGCACGAC TTCCAGGAGG AATTCGGCCT GGACCAGACT 
CAGGCTCTTG CCATCAGCGA CCACTTTCCA GTGGAGGTGA CCCTCAAGTT CCACCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNASE1L2 ( NM_001301680.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001288609.1 Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02910
Clone ID Related Accession (Same CDS sequence)	NM_001301680.2 , NM_001374.3 , NM_001374.2 , NM_001301680.1
Accession Version	NM_001301680.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-30
Organism	Homo sapiens(human)
Product	deoxyribonuclease-1-like 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC009065.8, BC063710.1 and BC035205.1. On May 31, 2019 this sequence version replaced NM_001301680.1. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035205.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCGGGC CCCGGGCTCT GCTGGCCGCA CTCTGGGCGC TGGAAGCCGC CGGGACCGCC 
GCGCTTCGCA TCGGAGCCTT CAACATTCAG AGCTTCGGTG ACAGCAAAGT GTCGGACCCC 
GCTTGCGGCA GCATCATCGC GAAGATCCTG GCTGGCTATG ACCTCGCGCT GGTGCAGGAG 
GTGCGAGACC CAGACCTCAG CGCCGTGTCC GCGCTCATGG AGCAGATCAA CAGCGTGTCC 
GAGCACGAGT ACAGCTTTGT GAGCAGCCAG CCCCTGGGCC GGGACCAGTA CAAGGAGATG 
TACCTGTTCG TGTACAGGAA AGACGCGGTG TCGGTCGTGG ACACCTACCT GTACCCAGAC 
CCCGAGGACG TCTTCAGCCG CGAGCCCTTC GTGGTCAAGT TCTCGGCCCC CGGCACCGGT 
GAGCGGGCCC CGCCCCTCCC CTCCCGCCGA GCTCTGACGC CCCCACCCCT TCCCGCAGCA 
GCACAGAACC TGGTGCTGAT CCCGCTGCAC GCGGCGCCGC ATCAAGCCGT GGCGGAGATC 
GACGCGCTCT ACGACGTGTA CCTGGACGTG ATCGACAAGT GGGGCACCGA CGACATGCTG 
TTCCTGGGCG ACTTCAACGC CGACTGCAGC TATGTGCGGG CGCAGGACTG GGCCGCCATC 
CGTCTGAGGA GCAGTGAGGT CTTCAAGTGG CTCATCCCTG ACAGCGCCGA CACCACGGTG 
GGCAACTCAG ACTGCGCCTA CGACCGCATT GTGGCCTGTG GCGCCCGCCT GCGCCGGAGC 
CTGAAGCCCC AGTCGGCCAC CGTGCACGAC TTCCAGGAGG AATTCGGCCT GGACCAGACT 
CAGGCTCTTG CCATCAGCGA CCACTTTCCA GTGGAGGTGA CCCTCAAGTT CCACCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288609.1
CDS	134..1033
Translation	MGGPRALLAALWALEAAGTAALRIGAFNIQSFGDSKVSDPACGSIIAKILAGYDLALVQEVRDPDLSAVSALMEQINSVSEHEYSFVSSQPLGRDQYKEMYLFVYRKDAVSVVDTYLYPDPEDVFSREPFVVKFSAPGTGERAPPLPSRRALTPPPLPAAAQNLVLIPLHAAPHQAVAEIDALYDVYLDVIDKWGTDDMLFLGDFNADCSYVRAQDWAAIRLRSSEVFKWLIPDSADTTVGNSDCAYDRIVACGARLRRSLKPQSATVHDFQEEFGLDQTQALAISDHFPVEVTLKFHR

Target ORF information:

RefSeq Version	NM_001301680.2
Organism	Homo sapiens(human)
Definition	Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301680.2

ORF Insert Sequence:

ATGGGCGGGC CCCGGGCTCT GCTGGCCGCA CTCTGGGCGC TGGAAGCCGC CGGGACCGCC 
GCGCTTCGCA TCGGAGCCTT CAACATTCAG AGCTTCGGTG ACAGCAAAGT GTCGGACCCC 
GCTTGCGGCA GCATCATCGC GAAGATCCTG GCTGGCTATG ACCTCGCGCT GGTGCAGGAG 
GTGCGAGACC CAGACCTCAG CGCCGTGTCC GCGCTCATGG AGCAGATCAA CAGCGTGTCC 
GAGCACGAGT ACAGCTTTGT GAGCAGCCAG CCCCTGGGCC GGGACCAGTA CAAGGAGATG 
TACCTGTTCG TGTACAGGAA AGACGCGGTG TCGGTCGTGG ACACCTACCT GTACCCAGAC 
CCCGAGGACG TCTTCAGCCG CGAGCCCTTC GTGGTCAAGT TCTCGGCCCC CGGCACCGGT 
GAGCGGGCCC CGCCCCTCCC CTCCCGCCGA GCTCTGACGC CCCCACCCCT TCCCGCAGCA 
GCACAGAACC TGGTGCTGAT CCCGCTGCAC GCGGCGCCGC ATCAAGCCGT GGCGGAGATC 
GACGCGCTCT ACGACGTGTA CCTGGACGTG ATCGACAAGT GGGGCACCGA CGACATGCTG 
TTCCTGGGCG ACTTCAACGC CGACTGCAGC TATGTGCGGG CGCAGGACTG GGCCGCCATC 
CGTCTGAGGA GCAGTGAGGT CTTCAAGTGG CTCATCCCTG ACAGCGCCGA CACCACGGTG 
GGCAACTCAG ACTGCGCCTA CGACCGCATT GTGGCCTGTG GCGCCCGCCT GCGCCGGAGC 
CTGAAGCCCC AGTCGGCCAC CGTGCACGAC TTCCAGGAGG AATTCGGCCT GGACCAGACT 
CAGGCTCTTG CCATCAGCGA CCACTTTCCA GTGGAGGTGA CCCTCAAGTT CCACCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNASE1L2 ( NM_001374.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001365.1 Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu02910
Clone ID Related Accession (Same CDS sequence)	NM_001301680.2 , NM_001374.3 , NM_001374.2 , NM_001301680.1
Accession Version	NM_001374.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	deoxyribonuclease-1-like 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC063710.1. On Jan 30, 2004 this sequence version replaced NM_001374.1. Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC063710.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCGGGC CCCGGGCTCT GCTGGCCGCA CTCTGGGCGC TGGAAGCCGC CGGGACCGCC 
GCGCTTCGCA TCGGAGCCTT CAACATTCAG AGCTTCGGTG ACAGCAAAGT GTCGGACCCC 
GCTTGCGGCA GCATCATCGC GAAGATCCTG GCTGGCTATG ACCTCGCGCT GGTGCAGGAG 
GTGCGAGACC CAGACCTCAG CGCCGTGTCC GCGCTCATGG AGCAGATCAA CAGCGTGTCC 
GAGCACGAGT ACAGCTTTGT GAGCAGCCAG CCCCTGGGCC GGGACCAGTA CAAGGAGATG 
TACCTGTTCG TGTACAGGAA AGACGCGGTG TCGGTCGTGG ACACCTACCT GTACCCAGAC 
CCCGAGGACG TCTTCAGCCG CGAGCCCTTC GTGGTCAAGT TCTCGGCCCC CGGCACCGGT 
GAGCGGGCCC CGCCCCTCCC CTCCCGCCGA GCTCTGACGC CCCCACCCCT TCCCGCAGCA 
GCACAGAACC TGGTGCTGAT CCCGCTGCAC GCGGCGCCGC ATCAAGCCGT GGCGGAGATC 
GACGCGCTCT ACGACGTGTA CCTGGACGTG ATCGACAAGT GGGGCACCGA CGACATGCTG 
TTCCTGGGCG ACTTCAACGC CGACTGCAGC TATGTGCGGG CGCAGGACTG GGCCGCCATC 
CGTCTGAGGA GCAGTGAGGT CTTCAAGTGG CTCATCCCTG ACAGCGCCGA CACCACGGTG 
GGCAACTCAG ACTGCGCCTA CGACCGCATT GTGGCCTGTG GCGCCCGCCT GCGCCGGAGC 
CTGAAGCCCC AGTCGGCCAC CGTGCACGAC TTCCAGGAGG AATTCGGCCT GGACCAGACT 
CAGGCTCTTG CCATCAGCGA CCACTTTCCA GTGGAGGTGA CCCTCAAGTT CCACCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001365.1
CDS	134..1033
Translation	MGGPRALLAALWALEAAGTAALRIGAFNIQSFGDSKVSDPACGSIIAKILAGYDLALVQEVRDPDLSAVSALMEQINSVSEHEYSFVSSQPLGRDQYKEMYLFVYRKDAVSVVDTYLYPDPEDVFSREPFVVKFSAPGTGERAPPLPSRRALTPPPLPAAAQNLVLIPLHAAPHQAVAEIDALYDVYLDVIDKWGTDDMLFLGDFNADCSYVRAQDWAAIRLRSSEVFKWLIPDSADTTVGNSDCAYDRIVACGARLRRSLKPQSATVHDFQEEFGLDQTQALAISDHFPVEVTLKFHR

Target ORF information:

RefSeq Version	NM_001374.2
Organism	Homo sapiens(human)
Definition	Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001374.2

ORF Insert Sequence:

ATGGGCGGGC CCCGGGCTCT GCTGGCCGCA CTCTGGGCGC TGGAAGCCGC CGGGACCGCC 
GCGCTTCGCA TCGGAGCCTT CAACATTCAG AGCTTCGGTG ACAGCAAAGT GTCGGACCCC 
GCTTGCGGCA GCATCATCGC GAAGATCCTG GCTGGCTATG ACCTCGCGCT GGTGCAGGAG 
GTGCGAGACC CAGACCTCAG CGCCGTGTCC GCGCTCATGG AGCAGATCAA CAGCGTGTCC 
GAGCACGAGT ACAGCTTTGT GAGCAGCCAG CCCCTGGGCC GGGACCAGTA CAAGGAGATG 
TACCTGTTCG TGTACAGGAA AGACGCGGTG TCGGTCGTGG ACACCTACCT GTACCCAGAC 
CCCGAGGACG TCTTCAGCCG CGAGCCCTTC GTGGTCAAGT TCTCGGCCCC CGGCACCGGT 
GAGCGGGCCC CGCCCCTCCC CTCCCGCCGA GCTCTGACGC CCCCACCCCT TCCCGCAGCA 
GCACAGAACC TGGTGCTGAT CCCGCTGCAC GCGGCGCCGC ATCAAGCCGT GGCGGAGATC 
GACGCGCTCT ACGACGTGTA CCTGGACGTG ATCGACAAGT GGGGCACCGA CGACATGCTG 
TTCCTGGGCG ACTTCAACGC CGACTGCAGC TATGTGCGGG CGCAGGACTG GGCCGCCATC 
CGTCTGAGGA GCAGTGAGGT CTTCAAGTGG CTCATCCCTG ACAGCGCCGA CACCACGGTG 
GGCAACTCAG ACTGCGCCTA CGACCGCATT GTGGCCTGTG GCGCCCGCCT GCGCCGGAGC 
CTGAAGCCCC AGTCGGCCAC CGTGCACGAC TTCCAGGAGG AATTCGGCCT GGACCAGACT 
CAGGCTCTTG CCATCAGCGA CCACTTTCCA GTGGAGGTGA CCCTCAAGTT CCACCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNASE1L2 ( NM_001301680.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001288609.1 Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu02910
Clone ID Related Accession (Same CDS sequence)	NM_001301680.2 , NM_001374.3 , NM_001374.2 , NM_001301680.1
Accession Version	NM_001301680.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 900bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	deoxyribonuclease-1-like 2 precursor
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC063710.1 and BC035205.1. On Sep 3, 2014 this sequence version replaced XM_005255152.2. Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC035205.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2145893, SAMEA2147596 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGCGGGC CCCGGGCTCT GCTGGCCGCA CTCTGGGCGC TGGAAGCCGC CGGGACCGCC 
GCGCTTCGCA TCGGAGCCTT CAACATTCAG AGCTTCGGTG ACAGCAAAGT GTCGGACCCC 
GCTTGCGGCA GCATCATCGC GAAGATCCTG GCTGGCTATG ACCTCGCGCT GGTGCAGGAG 
GTGCGAGACC CAGACCTCAG CGCCGTGTCC GCGCTCATGG AGCAGATCAA CAGCGTGTCC 
GAGCACGAGT ACAGCTTTGT GAGCAGCCAG CCCCTGGGCC GGGACCAGTA CAAGGAGATG 
TACCTGTTCG TGTACAGGAA AGACGCGGTG TCGGTCGTGG ACACCTACCT GTACCCAGAC 
CCCGAGGACG TCTTCAGCCG CGAGCCCTTC GTGGTCAAGT TCTCGGCCCC CGGCACCGGT 
GAGCGGGCCC CGCCCCTCCC CTCCCGCCGA GCTCTGACGC CCCCACCCCT TCCCGCAGCA 
GCACAGAACC TGGTGCTGAT CCCGCTGCAC GCGGCGCCGC ATCAAGCCGT GGCGGAGATC 
GACGCGCTCT ACGACGTGTA CCTGGACGTG ATCGACAAGT GGGGCACCGA CGACATGCTG 
TTCCTGGGCG ACTTCAACGC CGACTGCAGC TATGTGCGGG CGCAGGACTG GGCCGCCATC 
CGTCTGAGGA GCAGTGAGGT CTTCAAGTGG CTCATCCCTG ACAGCGCCGA CACCACGGTG 
GGCAACTCAG ACTGCGCCTA CGACCGCATT GTGGCCTGTG GCGCCCGCCT GCGCCGGAGC 
CTGAAGCCCC AGTCGGCCAC CGTGCACGAC TTCCAGGAGG AATTCGGCCT GGACCAGACT 
CAGGCTCTTG CCATCAGCGA CCACTTTCCA GTGGAGGTGA CCCTCAAGTT CCACCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001288609.1
CDS	111..1010
Translation	MGGPRALLAALWALEAAGTAALRIGAFNIQSFGDSKVSDPACGSIIAKILAGYDLALVQEVRDPDLSAVSALMEQINSVSEHEYSFVSSQPLGRDQYKEMYLFVYRKDAVSVVDTYLYPDPEDVFSREPFVVKFSAPGTGERAPPLPSRRALTPPPLPAAAQNLVLIPLHAAPHQAVAEIDALYDVYLDVIDKWGTDDMLFLGDFNADCSYVRAQDWAAIRLRSSEVFKWLIPDSADTTVGNSDCAYDRIVACGARLRRSLKPQSATVHDFQEEFGLDQTQALAISDHFPVEVTLKFHR

Target ORF information:

RefSeq Version	NM_001301680.1
Organism	Homo sapiens(human)
Definition	Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001301680.1

ORF Insert Sequence:

ATGGGCGGGC CCCGGGCTCT GCTGGCCGCA CTCTGGGCGC TGGAAGCCGC CGGGACCGCC 
GCGCTTCGCA TCGGAGCCTT CAACATTCAG AGCTTCGGTG ACAGCAAAGT GTCGGACCCC 
GCTTGCGGCA GCATCATCGC GAAGATCCTG GCTGGCTATG ACCTCGCGCT GGTGCAGGAG 
GTGCGAGACC CAGACCTCAG CGCCGTGTCC GCGCTCATGG AGCAGATCAA CAGCGTGTCC 
GAGCACGAGT ACAGCTTTGT GAGCAGCCAG CCCCTGGGCC GGGACCAGTA CAAGGAGATG 
TACCTGTTCG TGTACAGGAA AGACGCGGTG TCGGTCGTGG ACACCTACCT GTACCCAGAC 
CCCGAGGACG TCTTCAGCCG CGAGCCCTTC GTGGTCAAGT TCTCGGCCCC CGGCACCGGT 
GAGCGGGCCC CGCCCCTCCC CTCCCGCCGA GCTCTGACGC CCCCACCCCT TCCCGCAGCA 
GCACAGAACC TGGTGCTGAT CCCGCTGCAC GCGGCGCCGC ATCAAGCCGT GGCGGAGATC 
GACGCGCTCT ACGACGTGTA CCTGGACGTG ATCGACAAGT GGGGCACCGA CGACATGCTG 
TTCCTGGGCG ACTTCAACGC CGACTGCAGC TATGTGCGGG CGCAGGACTG GGCCGCCATC 
CGTCTGAGGA GCAGTGAGGT CTTCAAGTGG CTCATCCCTG ACAGCGCCGA CACCACGGTG 
GGCAACTCAG ACTGCGCCTA CGACCGCATT GTGGCCTGTG GCGCCCGCCT GCGCCGGAGC 
CTGAAGCCCC AGTCGGCCAC CGTGCACGAC TTCCAGGAGG AATTCGGCCT GGACCAGACT 
CAGGCTCTTG CCATCAGCGA CCACTTTCCA GTGGAGGTGA CCCTCAAGTT CCACCGATGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNASE1L2 ( XM_011522399.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011520701.1 Homo sapiens deoxyribonuclease I-like 2 (DNASE1L2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu57330
Clone ID Related Accession (Same CDS sequence)	XM_011522399.1 , XM_011522399.2
Accession Version	XM_011522399.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	deoxyribonuclease-1-like 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAATGA AAGCCAGGAG TTCATCAGGC ACCCAGCTGA GTCGAGGGGG CGGGACCCAG 
TGCAGCCCGG CCCCTCCCTG GCCCAGGACC TCAAATACCG GCCCCTGCCT TGGTGCCAGA 
GCTACTGCCA GAGGGAGTCA GTGCAGTCCT GTGTCGGACA CGCCCGCAGC CTGGACCCGG 
GATCCCCATC CCCCTAGGAT CTCTGAGCCT CGGGCCTCTG CACCCACATC CAAGGCGGCA 
GCGTCTGTCC CTCCCAGCCT CTCGCTCCGC GCCATGGGCG GGCCCCGGGC TCTGCTGGCC 
GCACTCTGGG CGCTGGAAGC CGCCGGGACC GCCGCGCTTC GCATCGGAGC CTTCAACATT 
CAGAGCTTCG GTGACAGCAA AGTGTCGGAC CCCGCTTGCG GCAGCATCAT CGCGAAGATC 
CTGGCTGGCT ATGACCTCGC GCTGGTGCAG GAGGTGCGAG ACCCAGACCT CAGCGCCGTG 
TCCGCGCTCA TGGAGCAGAT CAACAGCGTG TCCGAGCACG AGTACAGCTT TGTGAGCAGC 
CAGCCCCTGG GCCGGGACCA GTACAAGGAG ATGTACCTGT TCGTGTACAG GAAAGACGCG 
GTGTCGGTCG TGGACACCTA CCTGTACCCA GACCCCGAGG ACGTCTTCAG CCGCGAGCCC 
TTCGTGGTCA AGTTCTCGGC CCCCGGCACC GGTGAGCGGG CCCCGCCCCT CCCCTCCCGC 
CGAGCTCTGA CGCCCCCACC CCTTCCCGCA GCAGCACAGA ACCTGGTGCT GATCCCGCTG 
CACGCGGCGC CGCATCAAGC CGTGGCGGAG ATCGACGCGC TCTACGACGT GTACCTGGAC 
GTGATCGACA AGTGGGGCAC CGACGACATG CTGTTCCTGG GCGACTTCAA CGCCGACTGC 
AGCTATGTGC GGGCGCAGGA CTGGGCCGCC ATCCGTCTGA GGAGCAGTGA GGTCTTCAAG 
TGGCTCATCC CTGACAGCGC CGACACCACG GTGGGCAACT CAGACTGCGC CTACGACCGC 
ATTGTGGCCT GTGGCGCCCG CCTGCGCCGG AGCCTGAAGC CCCAGTCGGC CACCGTGCAC 
GACTTCCAGG AGGAATTCGG CCTGGACCAG ACTCAGGCTC TTGCCATCAG CGACCACTTT 
CCAGTGGAGG TGACCCTCAA GTTCCACCGA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011520701.1
CDS	76..1248
Translation	MGMKARSSSGTQLSRGGGTQCSPAPPWPRTSNTGPCLGARATARGSQCSPVSDTPAAWTRDPHPPRISEPRASAPTSKAAASVPPSLSLRAMGGPRALLAALWALEAAGTAALRIGAFNIQSFGDSKVSDPACGSIIAKILAGYDLALVQEVRDPDLSAVSALMEQINSVSEHEYSFVSSQPLGRDQYKEMYLFVYRKDAVSVVDTYLYPDPEDVFSREPFVVKFSAPGTGERAPPLPSRRALTPPPLPAAAQNLVLIPLHAAPHQAVAEIDALYDVYLDVIDKWGTDDMLFLGDFNADCSYVRAQDWAAIRLRSSEVFKWLIPDSADTTVGNSDCAYDRIVACGARLRRSLKPQSATVHDFQEEFGLDQTQALAISDHFPVEVTLKFHR

Target ORF information:

RefSeq Version	XM_011522399.1
Organism	Homo sapiens(human)
Definition	Homo sapiens deoxyribonuclease I-like 2 (DNASE1L2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522399.1

ORF Insert Sequence:

ATGGGAATGA AAGCCAGGAG TTCATCAGGC ACCCAGCTGA GTCGAGGGGG CGGGACCCAG 
TGCAGCCCGG CCCCTCCCTG GCCCAGGACC TCAAATACCG GCCCCTGCCT TGGTGCCAGA 
GCTACTGCCA GAGGGAGTCA GTGCAGTCCT GTGTCGGACA CGCCCGCAGC CTGGACCCGG 
GATCCCCATC CCCCTAGGAT CTCTGAGCCT CGGGCCTCTG CACCCACATC CAAGGCGGCA 
GCGTCTGTCC CTCCCAGCCT CTCGCTCCGC GCCATGGGCG GGCCCCGGGC TCTGCTGGCC 
GCACTCTGGG CGCTGGAAGC CGCCGGGACC GCCGCGCTTC GCATCGGAGC CTTCAACATT 
CAGAGCTTCG GTGACAGCAA AGTGTCGGAC CCCGCTTGCG GCAGCATCAT CGCGAAGATC 
CTGGCTGGCT ATGACCTCGC GCTGGTGCAG GAGGTGCGAG ACCCAGACCT CAGCGCCGTG 
TCCGCGCTCA TGGAGCAGAT CAACAGCGTG TCCGAGCACG AGTACAGCTT TGTGAGCAGC 
CAGCCCCTGG GCCGGGACCA GTACAAGGAG ATGTACCTGT TCGTGTACAG GAAAGACGCG 
GTGTCGGTCG TGGACACCTA CCTGTACCCA GACCCCGAGG ACGTCTTCAG CCGCGAGCCC 
TTCGTGGTCA AGTTCTCGGC CCCCGGCACC GGTGAGCGGG CCCCGCCCCT CCCCTCCCGC 
CGAGCTCTGA CGCCCCCACC CCTTCCCGCA GCAGCACAGA ACCTGGTGCT GATCCCGCTG 
CACGCGGCGC CGCATCAAGC CGTGGCGGAG ATCGACGCGC TCTACGACGT GTACCTGGAC 
GTGATCGACA AGTGGGGCAC CGACGACATG CTGTTCCTGG GCGACTTCAA CGCCGACTGC 
AGCTATGTGC GGGCGCAGGA CTGGGCCGCC ATCCGTCTGA GGAGCAGTGA GGTCTTCAAG 
TGGCTCATCC CTGACAGCGC CGACACCACG GTGGGCAACT CAGACTGCGC CTACGACCGC 
ATTGTGGCCT GTGGCGCCCG CCTGCGCCGG AGCCTGAAGC CCCAGTCGGC CACCGTGCAC 
GACTTCCAGG AGGAATTCGG CCTGGACCAG ACTCAGGCTC TTGCCATCAG CGACCACTTT 
CCAGTGGAGG TGACCCTCAA GTTCCACCGA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DNASE1L2 ( XM_011522399.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011520701.1 Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu57330
Clone ID Related Accession (Same CDS sequence)	XM_011522399.1 , XM_011522399.2
Accession Version	XM_011522399.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1173bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	deoxyribonuclease-1-like 2 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000016.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_011522399.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGGAATGA AAGCCAGGAG TTCATCAGGC ACCCAGCTGA GTCGAGGGGG CGGGACCCAG 
TGCAGCCCGG CCCCTCCCTG GCCCAGGACC TCAAATACCG GCCCCTGCCT TGGTGCCAGA 
GCTACTGCCA GAGGGAGTCA GTGCAGTCCT GTGTCGGACA CGCCCGCAGC CTGGACCCGG 
GATCCCCATC CCCCTAGGAT CTCTGAGCCT CGGGCCTCTG CACCCACATC CAAGGCGGCA 
GCGTCTGTCC CTCCCAGCCT CTCGCTCCGC GCCATGGGCG GGCCCCGGGC TCTGCTGGCC 
GCACTCTGGG CGCTGGAAGC CGCCGGGACC GCCGCGCTTC GCATCGGAGC CTTCAACATT 
CAGAGCTTCG GTGACAGCAA AGTGTCGGAC CCCGCTTGCG GCAGCATCAT CGCGAAGATC 
CTGGCTGGCT ATGACCTCGC GCTGGTGCAG GAGGTGCGAG ACCCAGACCT CAGCGCCGTG 
TCCGCGCTCA TGGAGCAGAT CAACAGCGTG TCCGAGCACG AGTACAGCTT TGTGAGCAGC 
CAGCCCCTGG GCCGGGACCA GTACAAGGAG ATGTACCTGT TCGTGTACAG GAAAGACGCG 
GTGTCGGTCG TGGACACCTA CCTGTACCCA GACCCCGAGG ACGTCTTCAG CCGCGAGCCC 
TTCGTGGTCA AGTTCTCGGC CCCCGGCACC GGTGAGCGGG CCCCGCCCCT CCCCTCCCGC 
CGAGCTCTGA CGCCCCCACC CCTTCCCGCA GCAGCACAGA ACCTGGTGCT GATCCCGCTG 
CACGCGGCGC CGCATCAAGC CGTGGCGGAG ATCGACGCGC TCTACGACGT GTACCTGGAC 
GTGATCGACA AGTGGGGCAC CGACGACATG CTGTTCCTGG GCGACTTCAA CGCCGACTGC 
AGCTATGTGC GGGCGCAGGA CTGGGCCGCC ATCCGTCTGA GGAGCAGTGA GGTCTTCAAG 
TGGCTCATCC CTGACAGCGC CGACACCACG GTGGGCAACT CAGACTGCGC CTACGACCGC 
ATTGTGGCCT GTGGCGCCCG CCTGCGCCGG AGCCTGAAGC CCCAGTCGGC CACCGTGCAC 
GACTTCCAGG AGGAATTCGG CCTGGACCAG ACTCAGGCTC TTGCCATCAG CGACCACTTT 
CCAGTGGAGG TGACCCTCAA GTTCCACCGA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011520701.1
CDS	512..1684
Translation	MGMKARSSSGTQLSRGGGTQCSPAPPWPRTSNTGPCLGARATARGSQCSPVSDTPAAWTRDPHPPRISEPRASAPTSKAAASVPPSLSLRAMGGPRALLAALWALEAAGTAALRIGAFNIQSFGDSKVSDPACGSIIAKILAGYDLALVQEVRDPDLSAVSALMEQINSVSEHEYSFVSSQPLGRDQYKEMYLFVYRKDAVSVVDTYLYPDPEDVFSREPFVVKFSAPGTGERAPPLPSRRALTPPPLPAAAQNLVLIPLHAAPHQAVAEIDALYDVYLDVIDKWGTDDMLFLGDFNADCSYVRAQDWAAIRLRSSEVFKWLIPDSADTTVGNSDCAYDRIVACGARLRRSLKPQSATVHDFQEEFGLDQTQALAISDHFPVEVTLKFHR

Target ORF information:

RefSeq Version	XM_011522399.2
Organism	Homo sapiens(human)
Definition	Homo sapiens deoxyribonuclease 1 like 2 (DNASE1L2), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011522399.2

ORF Insert Sequence:

ATGGGAATGA AAGCCAGGAG TTCATCAGGC ACCCAGCTGA GTCGAGGGGG CGGGACCCAG 
TGCAGCCCGG CCCCTCCCTG GCCCAGGACC TCAAATACCG GCCCCTGCCT TGGTGCCAGA 
GCTACTGCCA GAGGGAGTCA GTGCAGTCCT GTGTCGGACA CGCCCGCAGC CTGGACCCGG 
GATCCCCATC CCCCTAGGAT CTCTGAGCCT CGGGCCTCTG CACCCACATC CAAGGCGGCA 
GCGTCTGTCC CTCCCAGCCT CTCGCTCCGC GCCATGGGCG GGCCCCGGGC TCTGCTGGCC 
GCACTCTGGG CGCTGGAAGC CGCCGGGACC GCCGCGCTTC GCATCGGAGC CTTCAACATT 
CAGAGCTTCG GTGACAGCAA AGTGTCGGAC CCCGCTTGCG GCAGCATCAT CGCGAAGATC 
CTGGCTGGCT ATGACCTCGC GCTGGTGCAG GAGGTGCGAG ACCCAGACCT CAGCGCCGTG 
TCCGCGCTCA TGGAGCAGAT CAACAGCGTG TCCGAGCACG AGTACAGCTT TGTGAGCAGC 
CAGCCCCTGG GCCGGGACCA GTACAAGGAG ATGTACCTGT TCGTGTACAG GAAAGACGCG 
GTGTCGGTCG TGGACACCTA CCTGTACCCA GACCCCGAGG ACGTCTTCAG CCGCGAGCCC 
TTCGTGGTCA AGTTCTCGGC CCCCGGCACC GGTGAGCGGG CCCCGCCCCT CCCCTCCCGC 
CGAGCTCTGA CGCCCCCACC CCTTCCCGCA GCAGCACAGA ACCTGGTGCT GATCCCGCTG 
CACGCGGCGC CGCATCAAGC CGTGGCGGAG ATCGACGCGC TCTACGACGT GTACCTGGAC 
GTGATCGACA AGTGGGGCAC CGACGACATG CTGTTCCTGG GCGACTTCAA CGCCGACTGC 
AGCTATGTGC GGGCGCAGGA CTGGGCCGCC ATCCGTCTGA GGAGCAGTGA GGTCTTCAAG 
TGGCTCATCC CTGACAGCGC CGACACCACG GTGGGCAACT CAGACTGCGC CTACGACCGC 
ATTGTGGCCT GTGGCGCCCG CCTGCGCCGG AGCCTGAAGC CCCAGTCGGC CACCGTGCAC 
GACTTCCAGG AGGAATTCGG CCTGGACCAG ACTCAGGCTC TTGCCATCAG CGACCACTTT 
CCAGTGGAGG TGACCCTCAA GTTCCACCGA TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Survey of single-nucleotide polymorphisms in the gene encoding human deoxyribonuclease I-like 2 producing loss of function potentially implicated in the pathogenesis of parakeratosis.
PloS one12(4)e0175083(2017)
Ueki M,Takeshita H,Utsunomiya N,Chino T,Oyama N,Hasegawa M,Kimura-Kataoka K,Fujihara J,Iida R,Yasuda T

Identification of functional SNPs potentially served as a genetic risk factor for the pathogenesis of parakeratosis in the gene encoding human deoxyribonuclease I-like 2 (DNase 1L2) implicated in terminal differentiation of keratinocytes.
Gene561(1)15-22(2015 Apr)
Ueki M,Takeshita H,Kimura-Kataoka K,Fujihara J,Iida R,Yasuda T

Five non-synonymous SNPs in the gene encoding human deoxyribonuclease I-like 2 implicated in terminal differentiation of keratinocytes reduce or abolish its activity.
Electrophoresis34(3)456-62(2013 Feb)
Ueki M,Fujihara J,Kimura-Kataoka K,Takeshita H,Iida R,Yasuda T

Global analysis of single nucleotide polymorphisms in the exons of human deoxyribonuclease I-like 1 and 2 genes.
Electrophoresis31(21)3552-7(2010 Oct)
Fujihara J,Yasuda T,Iida R,Kimura-Kataoka K,Soejima M,Koda Y,Kato H,Panduro A,Yuasa I,Takeshita H

Genetic and expression analysis of all non-synonymous single nucleotide polymorphisms in the human deoxyribonuclease I-like 1 and 2 genes.
Electrophoresis31(12)2063-9(2010 Jun)
Ueki M,Fujihara J,Takeshita H,Kimura-Kataoka K,Iida R,Nakajima T,Kominato Y,Yuasa I,Yasuda T

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DNASE1L2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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