DMWD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DMWD
Entrez Gene ID	1762
Full Name	DM1 locus, WD repeat containing
Synonyms	D19S593E,DMR-N9,DMRN9,gene59
General protein information	Preferred Names DM1 locus, WD repeat containing Names dystrophia myotonica WD repeat-containing protein dystrophia myotonica, WD repeat containing dystrophia myotonica-containing WD repeat motif protein protein 59
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19q13.32
Disorder MIM:	609857

mRNA and Protein(s)

mRNA	Protein	Name
NM_004943.2	NP_004934.1	dystrophia myotonica WD repeat-containing protein
NM_004943.1	NP_004934.1	dystrophia myotonica WD repeat-containing protein

Pathways from BioSystems

Homologies

Homo sapiens (human)	DMWD	NP_004934.1
Pan troglodytes (chimpanzee)	DMWD	XP_001166545.1
Danio rerio (zebrafish)	LOC571996	XP_700740.5
Rattus norvegicus (Norway rat)	Dmwd	XP_006228596.1
Mus musculus (house mouse)	Dmwd	NP_034188.2
Canis lupus familiaris (dog)	DMWD	XP_541550.3
Bos taurus (cattle)	DMWD	XP_002695143.1

Gene Ontology
Bibliography

Related articles in PubMed

Myotonic dystrophy type 1: role of CCG, CTC and CGG interruptions within DMPK alleles in the pathogenesis and molecular diagnosis.
Santoro M, Masciullo M, Silvestri G, Novelli G, Botta A
Clinical genetics92(4)355-364(2017 Oct)

A germline-specific class of small RNAs binds mammalian Piwi proteins.
Girard A, Sachidanandam R, Hannon GJ, Carmell MA
Nature442(7099)199-202(2006 Jul)

Large-scale characterization of HeLa cell nuclear phosphoproteins.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Vill?n J, Li J, Cohn MA, Cantley LC, Gygi SP
Proceedings of the National Academy of Sciences of the United States of America101(33)12130-5(2004 Aug)

The DNA sequence and biology of human chromosome 19.
Grimwood J, Gordon LA, Olsen A, Terry A, Schmutz J, Lamerdin J, Hellsten U, Goodstein D, Couronne O, Tran-Gyamfi M, Aerts A, Altherr M, Ashworth L, Bajorek E, Black S, Branscomb E, Caenepeel S, Carrano A, Caoile C, Chan YM, Christensen M, Cleland CA, Copeland A, Dalin E, Dehal P, Denys M, Detter JC, Escobar J, Flowers D, Fotopulos D, Garcia C, Georgescu AM, Glavina T, Gomez M, Gonzales E, Groza M, Hammon N, Hawkins T, Haydu L, Ho I, Huang W, Israni S, Jett J, Kadner K, Kimball H, Kobayashi A, Larionov V, Leem SH, Lopez F, Lou Y, Lowry S, Malfatti S, Martinez D, McCready P, Medina C, Morgan J, Nelson K, Nolan M, Ovcharenko I, Pitluck S, Pollard M, Popkie AP, Predki P, Quan G, Ramirez L, Rash S, Retterer J, Rodriguez A, Rogers S, Salamov A, Salazar A, She X, Smith D, Slezak T, Solovyev V, Thayer N, Tice H, Tsai M, Ustaszewska A, Vo N, Wagner M, Wheeler J, Wu K, Xie G, Yang J, Dubchak I, Furey TS, DeJong P, Dickson M, Gordon D, Eichler EE, Pennacchio LA, Richardson P, Stubbs L, Rokhsar DS, Myers RM, Rubin EM, Lucas SM
Nature428(6982)529-35(2004 Apr)

Transgenic mouse models for myotonic dystrophy type 1 (DM1).
Wansink DG, Wieringa B
Cytogenetic and genome research100(1-4)230-42(2003)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The following DMWD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DMWD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu04723	NM_004943.2 Latest version!	Homo sapiens DM1 locus, WD repeat containing (DMWD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
View Old Accession Versions >>
OHu04723	NM_004943.1	Homo sapiens DM1 locus, WD repeat containing (DMWD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DMWD ( NM_004943.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_004934.1 Homo sapiens DM1 locus, WD repeat containing (DMWD), mRNA.

Price & Availability↑

CloneID	OHu04723
Clone ID Related Accession (Same CDS sequence)	NM_004943.2 , NM_004943.1
Accession Version	NM_004943.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2025bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-24
Organism	Homo sapiens(human)
Product	dystrophia myotonica WD repeat-containing protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from AC011530.6, BM922103.1, L19267.1, BG106514.1, BC019266.1, CD106470.1, BX283745.1, BC041034.1 and BQ189202.1. On Nov 22, 2018 this sequence version replaced NM_004943.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L19267.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000270223.7/ ENSP00000270223.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGCGGCGG GCGGCGCGGA GGGCGGCTCG GGCCCCGGCG CCGCCATGGG GGACTGCGCG 
GAGATTAAGT CGCAATTCCG CACGCGCGAG GGTTTCTACA AGCTACTCCC GGGCGACGGC 
GCCGCTCGCA GGTCGGGTCC GGCTTCCGCC CAGACTCCGG TGCCGCCTCA GCCACCGCAG 
CCCCCGCCCG GCCCTGCCTC CGCCTCCGGT CCCGGCGCTG CAGGCCCCGC GTCGTCCCCG 
CCGCCCGCAG GCCCCGGACC CGGGCCCGCC CTGCCCGCCG TGCGCCTCAG CCTCGTGCGC 
CTCGGGGAGC CGGACAGCGC CGGGGCCGGG GAGCCGCCCG CCACGCCCGC GGGGCTGGGC 
TCGGGGGGAG ACCGCGTCTG CTTCAACTTG GGCCGTGAGC TCTATTTCTA CCCAGGCTGC 
TGTCGTCGTG GGAGCCAACG GTCCATTGAC CTCAACAAGC CAATTGACAA GCGGATCTAC 
AAGGGCACCC AGCCCACCTG CCACGATTTC AACCAGTTCA CTGCTGCCAC CGAGACCATC 
TCGCTGCTGG TGGGCTTCTC AGCGGGTCAA GTGCAGTACC TGGATCTCAT CAAAAAGGAC 
ACCAGCAAGC TGTTCAATGA GGAGCGGTTG ATCGACAAGA CCAAGGTGAC ATATCTGAAG 
TGGCTGCCTG AGTCGGAGAG CCTGTTCCTG GCATCACACG CCAGTGGCCA CCTGTACCTG 
TACAACGTCA GCCACCCCTG CGCCTCGGCC CCGCCCCAGT ACAGCCTGCT GAAGCAGGGC 
GAGGGCTTCT CTGTCTATGC TGCCAAGAGC AAGGCACCCC GCAACCCGCT GGCCAAGTGG 
GCGGTGGGTG AGGGGCCCCT CAACGAGTTC GCCTTCTCGC CCGATGGCCG GCACCTGGCC 
TGTGTGAGCC AGGATGGCTG CCTGCGCGTC TTCCACTTCG ACTCCATGCT CCTGCGTGGG 
CTCATGAAGA GCTACTTTGG GGGCCTGCTG TGTGTGTGCT GGAGCCCTGA CGGCCGCTAC 
GTGGTGACGG GTGGCGAAGA TGACCTGGTC ACCGTGTGGT CCTTCACCGA GGGCCGCGTG 
GTGGCTCGAG GCCATGGCCA CAAGTCCTGG GTCAACGCTG TGGCCTTTGA CCCCTACACC 
ACAAGGGCAG AGGAGGCGGC GACAGCAGCC GGTGCTGATG GGGAGCGGAG CGGCGAAGAG 
GAGGAGGAGG AGCCCGAGGC TGCGGGCACA GGCTCGGCCG GGGGCGCCCC GCTCTCTCCA 
CTGCCCAAGG CTGGCTCCAT TACTTACCGC TTTGGCTCGG CGGGCCAGGA CACGCAGTTC 
TGCCTGTGGG ACCTCACTGA AGACGTGCTC TACCCGCACC CCCCCCTGGC CCGCACCCGC 
ACCCTCCCTG GCACACCTGG CACCACGCCA CCGGCCGCCA GCAGCTCGAG GGGTGGCGAG 
CCTGGCCCAG GCCCCCTGCC TCGCTCGCTG TCCCGCTCCA ACAGTCTCCC GCACCCAGCT 
GGCGGGGGCA AGGCGGGCGG CCCGGGTGTG GCGGCAGAGC CTGGCACACC ATTCAGCATT 
GGCCGCTTCG CCACGCTCAC ACTGCAGGAG CGGCGGGACC GGGGGGCAGA GAAGGAGCAC 
AAGCGCTACC ACAGCCTGGG CAACATCAGC CGGGGTGGCA GTGGCGGCAG TGGCAGTGGT 
GGGGAGAAGC CCAGCGGCCC TGTTCCCCGC AGCCGCCTGG ACCCCGCCAA GGTGCTGGGC 
ACTGCGCTGT GCCCGCGCAT CCACGAGGTG CCCCTGCTGG AGCCCCTTGT GTGCAAGAAG 
ATCGCCCAGG AGCGGCTCAC AGTCCTCCTG TTCCTGGAGG ACTGCATCAT CACTGCCTGC 
CAGGAGGGCC TCATCTGCAC CTGGGCCCGG CCGGGCAAGG CGTTCACAGA CGAGGAGACC 
GAGGCCCAGA CAGGGGAAGG AAGTTGGCCC AGGTCACCCA GCAAGTCAGT GGTAGAGGGC 
ATCTCCTCCC AACCAGGCAA CTCCCCGAGT GGCACAGTGG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004934.1
CDS	90..2114
Translation	MAAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGCCRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETISLLVGFSAGQVQYLDLIKKDTSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYLYNVSHPCASAPPQYSLLKQGEGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYTTRAEEAATAAGADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKKIAQERLTVLLFLEDCIITACQEGLICTWARPGKAFTDEETEAQTGEGSWPRSPSKSVVEGISSQPGNSPSGTVV

Target ORF information:

RefSeq Version	NM_004943.2
Organism	Homo sapiens(human)
Definition	Homo sapiens DM1 locus, WD repeat containing (DMWD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004943.2

ORF Insert Sequence:

ATGGCGGCGG GCGGCGCGGA GGGCGGCTCG GGCCCCGGCG CCGCCATGGG GGACTGCGCG 
GAGATTAAGT CGCAATTCCG CACGCGCGAG GGTTTCTACA AGCTACTCCC GGGCGACGGC 
GCCGCTCGCA GGTCGGGTCC GGCTTCCGCC CAGACTCCGG TGCCGCCTCA GCCACCGCAG 
CCCCCGCCCG GCCCTGCCTC CGCCTCCGGT CCCGGCGCTG CAGGCCCCGC GTCGTCCCCG 
CCGCCCGCAG GCCCCGGACC CGGGCCCGCC CTGCCCGCCG TGCGCCTCAG CCTCGTGCGC 
CTCGGGGAGC CGGACAGCGC CGGGGCCGGG GAGCCGCCCG CCACGCCCGC GGGGCTGGGC 
TCGGGGGGAG ACCGCGTCTG CTTCAACTTG GGCCGTGAGC TCTATTTCTA CCCAGGCTGC 
TGTCGTCGTG GGAGCCAACG GTCCATTGAC CTCAACAAGC CAATTGACAA GCGGATCTAC 
AAGGGCACCC AGCCCACCTG CCACGATTTC AACCAGTTCA CTGCTGCCAC CGAGACCATC 
TCGCTGCTGG TGGGCTTCTC AGCGGGTCAA GTGCAGTACC TGGATCTCAT CAAAAAGGAC 
ACCAGCAAGC TGTTCAATGA GGAGCGGTTG ATCGACAAGA CCAAGGTGAC ATATCTGAAG 
TGGCTGCCTG AGTCGGAGAG CCTGTTCCTG GCATCACACG CCAGTGGCCA CCTGTACCTG 
TACAACGTCA GCCACCCCTG CGCCTCGGCC CCGCCCCAGT ACAGCCTGCT GAAGCAGGGC 
GAGGGCTTCT CTGTCTATGC TGCCAAGAGC AAGGCACCCC GCAACCCGCT GGCCAAGTGG 
GCGGTGGGTG AGGGGCCCCT CAACGAGTTC GCCTTCTCGC CCGATGGCCG GCACCTGGCC 
TGTGTGAGCC AGGATGGCTG CCTGCGCGTC TTCCACTTCG ACTCCATGCT CCTGCGTGGG 
CTCATGAAGA GCTACTTTGG GGGCCTGCTG TGTGTGTGCT GGAGCCCTGA CGGCCGCTAC 
GTGGTGACGG GTGGCGAAGA TGACCTGGTC ACCGTGTGGT CCTTCACCGA GGGCCGCGTG 
GTGGCTCGAG GCCATGGCCA CAAGTCCTGG GTCAACGCTG TGGCCTTTGA CCCCTACACC 
ACAAGGGCAG AGGAGGCGGC GACAGCAGCC GGTGCTGATG GGGAGCGGAG CGGCGAAGAG 
GAGGAGGAGG AGCCCGAGGC TGCGGGCACA GGCTCGGCCG GGGGCGCCCC GCTCTCTCCA 
CTGCCCAAGG CTGGCTCCAT TACTTACCGC TTTGGCTCGG CGGGCCAGGA CACGCAGTTC 
TGCCTGTGGG ACCTCACTGA AGACGTGCTC TACCCGCACC CCCCCCTGGC CCGCACCCGC 
ACCCTCCCTG GCACACCTGG CACCACGCCA CCGGCCGCCA GCAGCTCGAG GGGTGGCGAG 
CCTGGCCCAG GCCCCCTGCC TCGCTCGCTG TCCCGCTCCA ACAGTCTCCC GCACCCAGCT 
GGCGGGGGCA AGGCGGGCGG CCCGGGTGTG GCGGCAGAGC CTGGCACACC ATTCAGCATT 
GGCCGCTTCG CCACGCTCAC ACTGCAGGAG CGGCGGGACC GGGGGGCAGA GAAGGAGCAC 
AAGCGCTACC ACAGCCTGGG CAACATCAGC CGGGGTGGCA GTGGCGGCAG TGGCAGTGGT 
GGGGAGAAGC CCAGCGGCCC TGTTCCCCGC AGCCGCCTGG ACCCCGCCAA GGTGCTGGGC 
ACTGCGCTGT GCCCGCGCAT CCACGAGGTG CCCCTGCTGG AGCCCCTTGT GTGCAAGAAG 
ATCGCCCAGG AGCGGCTCAC AGTCCTCCTG TTCCTGGAGG ACTGCATCAT CACTGCCTGC 
CAGGAGGGCC TCATCTGCAC CTGGGCCCGG CCGGGCAAGG CGTTCACAGA CGAGGAGACC 
GAGGCCCAGA CAGGGGAAGG AAGTTGGCCC AGGTCACCCA GCAAGTCAGT GGTAGAGGGC 
ATCTCCTCCC AACCAGGCAA CTCCCCGAGT GGCACAGTGG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DMWD ( NM_004943.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_004934.1 Homo sapiens DM1 locus, WD repeat containing (DMWD), mRNA.

Price & Availability↑

CloneID	OHu04723
Clone ID Related Accession (Same CDS sequence)	NM_004943.2 , NM_004943.1
Accession Version	NM_004943.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2025bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-25
Organism	Homo sapiens(human)
Product	dystrophia myotonica WD repeat-containing protein
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BM922103.1, L19267.1, BG106514.1, BC019266.1, CD106470.1, BX283745.1, BC041034.1 and BQ189202.1. On Apr 29, 2005 this sequence version replaced XM_496318.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: L19267.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END##

ATGGCGGCGG GCGGCGCGGA GGGCGGCTCG GGCCCCGGCG CCGCCATGGG GGACTGCGCG 
GAGATTAAGT CGCAATTCCG CACGCGCGAG GGTTTCTACA AGCTACTCCC GGGCGACGGC 
GCCGCTCGCA GGTCGGGTCC GGCTTCCGCC CAGACTCCGG TGCCGCCTCA GCCACCGCAG 
CCCCCGCCCG GCCCTGCCTC CGCCTCCGGT CCCGGCGCTG CAGGCCCCGC GTCGTCCCCG 
CCGCCCGCAG GCCCCGGACC CGGGCCCGCC CTGCCCGCCG TGCGCCTCAG CCTCGTGCGC 
CTCGGGGAGC CGGACAGCGC CGGGGCCGGG GAGCCGCCCG CCACGCCCGC GGGGCTGGGC 
TCGGGGGGAG ACCGCGTCTG CTTCAACTTG GGCCGTGAGC TCTATTTCTA CCCAGGCTGC 
TGTCGTCGTG GGAGCCAACG GTCCATTGAC CTCAACAAGC CAATTGACAA GCGGATCTAC 
AAGGGCACCC AGCCCACCTG CCACGATTTC AACCAGTTCA CTGCTGCCAC CGAGACCATC 
TCGCTGCTGG TGGGCTTCTC AGCGGGTCAA GTGCAGTACC TGGATCTCAT CAAAAAGGAC 
ACCAGCAAGC TGTTCAATGA GGAGCGGTTG ATCGACAAGA CCAAGGTGAC ATATCTGAAG 
TGGCTGCCTG AGTCGGAGAG CCTGTTCCTG GCATCACACG CCAGTGGCCA CCTGTACCTG 
TACAACGTCA GCCACCCCTG CGCCTCGGCC CCGCCCCAGT ACAGCCTGCT GAAGCAGGGC 
GAGGGCTTCT CTGTCTATGC TGCCAAGAGC AAGGCACCCC GCAACCCGCT GGCCAAGTGG 
GCGGTGGGTG AGGGGCCCCT CAACGAGTTC GCCTTCTCGC CCGATGGCCG GCACCTGGCC 
TGTGTGAGCC AGGATGGCTG CCTGCGCGTC TTCCACTTCG ACTCCATGCT CCTGCGTGGG 
CTCATGAAGA GCTACTTTGG GGGCCTGCTG TGTGTGTGCT GGAGCCCTGA CGGCCGCTAC 
GTGGTGACGG GTGGCGAAGA TGACCTGGTC ACCGTGTGGT CCTTCACCGA GGGCCGCGTG 
GTGGCTCGAG GCCATGGCCA CAAGTCCTGG GTCAACGCTG TGGCCTTTGA CCCCTACACC 
ACAAGGGCAG AGGAGGCGGC GACAGCAGCC GGTGCTGATG GGGAGCGGAG CGGCGAAGAG 
GAGGAGGAGG AGCCCGAGGC TGCGGGCACA GGCTCGGCCG GGGGCGCCCC GCTCTCTCCA 
CTGCCCAAGG CTGGCTCCAT TACTTACCGC TTTGGCTCGG CGGGCCAGGA CACGCAGTTC 
TGCCTGTGGG ACCTCACTGA AGACGTGCTC TACCCGCACC CCCCCCTGGC CCGCACCCGC 
ACCCTCCCTG GCACACCTGG CACCACGCCA CCGGCCGCCA GCAGCTCGAG GGGTGGCGAG 
CCTGGCCCAG GCCCCCTGCC TCGCTCGCTG TCCCGCTCCA ACAGTCTCCC GCACCCAGCT 
GGCGGGGGCA AGGCGGGCGG CCCGGGTGTG GCGGCAGAGC CTGGCACACC ATTCAGCATT 
GGCCGCTTCG CCACGCTCAC ACTGCAGGAG CGGCGGGACC GGGGGGCAGA GAAGGAGCAC 
AAGCGCTACC ACAGCCTGGG CAACATCAGC CGGGGTGGCA GTGGCGGCAG TGGCAGTGGT 
GGGGAGAAGC CCAGCGGCCC TGTTCCCCGC AGCCGCCTGG ACCCCGCCAA GGTGCTGGGC 
ACTGCGCTGT GCCCGCGCAT CCACGAGGTG CCCCTGCTGG AGCCCCTTGT GTGCAAGAAG 
ATCGCCCAGG AGCGGCTCAC AGTCCTCCTG TTCCTGGAGG ACTGCATCAT CACTGCCTGC 
CAGGAGGGCC TCATCTGCAC CTGGGCCCGG CCGGGCAAGG CGTTCACAGA CGAGGAGACC 
GAGGCCCAGA CAGGGGAAGG AAGTTGGCCC AGGTCACCCA GCAAGTCAGT GGTAGAGGGC 
ATCTCCTCCC AACCAGGCAA CTCCCCGAGT GGCACAGTGG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004934.1
CDS	47..2071
Translation	MAAGGAEGGSGPGAAMGDCAEIKSQFRTREGFYKLLPGDGAARRSGPASAQTPVPPQPPQPPPGPASASGPGAAGPASSPPPAGPGPGPALPAVRLSLVRLGEPDSAGAGEPPATPAGLGSGGDRVCFNLGRELYFYPGCCRRGSQRSIDLNKPIDKRIYKGTQPTCHDFNQFTAATETISLLVGFSAGQVQYLDLIKKDTSKLFNEERLIDKTKVTYLKWLPESESLFLASHASGHLYLYNVSHPCASAPPQYSLLKQGEGFSVYAAKSKAPRNPLAKWAVGEGPLNEFAFSPDGRHLACVSQDGCLRVFHFDSMLLRGLMKSYFGGLLCVCWSPDGRYVVTGGEDDLVTVWSFTEGRVVARGHGHKSWVNAVAFDPYTTRAEEAATAAGADGERSGEEEEEEPEAAGTGSAGGAPLSPLPKAGSITYRFGSAGQDTQFCLWDLTEDVLYPHPPLARTRTLPGTPGTTPPAASSSRGGEPGPGPLPRSLSRSNSLPHPAGGGKAGGPGVAAEPGTPFSIGRFATLTLQERRDRGAEKEHKRYHSLGNISRGGSGGSGSGGEKPSGPVPRSRLDPAKVLGTALCPRIHEVPLLEPLVCKKIAQERLTVLLFLEDCIITACQEGLICTWARPGKAFTDEETEAQTGEGSWPRSPSKSVVEGISSQPGNSPSGTVV

Target ORF information:

RefSeq Version	NM_004943.1
Organism	Homo sapiens(human)
Definition	Homo sapiens DM1 locus, WD repeat containing (DMWD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004943.1

ORF Insert Sequence:

ATGGCGGCGG GCGGCGCGGA GGGCGGCTCG GGCCCCGGCG CCGCCATGGG GGACTGCGCG 
GAGATTAAGT CGCAATTCCG CACGCGCGAG GGTTTCTACA AGCTACTCCC GGGCGACGGC 
GCCGCTCGCA GGTCGGGTCC GGCTTCCGCC CAGACTCCGG TGCCGCCTCA GCCACCGCAG 
CCCCCGCCCG GCCCTGCCTC CGCCTCCGGT CCCGGCGCTG CAGGCCCCGC GTCGTCCCCG 
CCGCCCGCAG GCCCCGGACC CGGGCCCGCC CTGCCCGCCG TGCGCCTCAG CCTCGTGCGC 
CTCGGGGAGC CGGACAGCGC CGGGGCCGGG GAGCCGCCCG CCACGCCCGC GGGGCTGGGC 
TCGGGGGGAG ACCGCGTCTG CTTCAACTTG GGCCGTGAGC TCTATTTCTA CCCAGGCTGC 
TGTCGTCGTG GGAGCCAACG GTCCATTGAC CTCAACAAGC CAATTGACAA GCGGATCTAC 
AAGGGCACCC AGCCCACCTG CCACGATTTC AACCAGTTCA CTGCTGCCAC CGAGACCATC 
TCGCTGCTGG TGGGCTTCTC AGCGGGTCAA GTGCAGTACC TGGATCTCAT CAAAAAGGAC 
ACCAGCAAGC TGTTCAATGA GGAGCGGTTG ATCGACAAGA CCAAGGTGAC ATATCTGAAG 
TGGCTGCCTG AGTCGGAGAG CCTGTTCCTG GCATCACACG CCAGTGGCCA CCTGTACCTG 
TACAACGTCA GCCACCCCTG CGCCTCGGCC CCGCCCCAGT ACAGCCTGCT GAAGCAGGGC 
GAGGGCTTCT CTGTCTATGC TGCCAAGAGC AAGGCACCCC GCAACCCGCT GGCCAAGTGG 
GCGGTGGGTG AGGGGCCCCT CAACGAGTTC GCCTTCTCGC CCGATGGCCG GCACCTGGCC 
TGTGTGAGCC AGGATGGCTG CCTGCGCGTC TTCCACTTCG ACTCCATGCT CCTGCGTGGG 
CTCATGAAGA GCTACTTTGG GGGCCTGCTG TGTGTGTGCT GGAGCCCTGA CGGCCGCTAC 
GTGGTGACGG GTGGCGAAGA TGACCTGGTC ACCGTGTGGT CCTTCACCGA GGGCCGCGTG 
GTGGCTCGAG GCCATGGCCA CAAGTCCTGG GTCAACGCTG TGGCCTTTGA CCCCTACACC 
ACAAGGGCAG AGGAGGCGGC GACAGCAGCC GGTGCTGATG GGGAGCGGAG CGGCGAAGAG 
GAGGAGGAGG AGCCCGAGGC TGCGGGCACA GGCTCGGCCG GGGGCGCCCC GCTCTCTCCA 
CTGCCCAAGG CTGGCTCCAT TACTTACCGC TTTGGCTCGG CGGGCCAGGA CACGCAGTTC 
TGCCTGTGGG ACCTCACTGA AGACGTGCTC TACCCGCACC CCCCCCTGGC CCGCACCCGC 
ACCCTCCCTG GCACACCTGG CACCACGCCA CCGGCCGCCA GCAGCTCGAG GGGTGGCGAG 
CCTGGCCCAG GCCCCCTGCC TCGCTCGCTG TCCCGCTCCA ACAGTCTCCC GCACCCAGCT 
GGCGGGGGCA AGGCGGGCGG CCCGGGTGTG GCGGCAGAGC CTGGCACACC ATTCAGCATT 
GGCCGCTTCG CCACGCTCAC ACTGCAGGAG CGGCGGGACC GGGGGGCAGA GAAGGAGCAC 
AAGCGCTACC ACAGCCTGGG CAACATCAGC CGGGGTGGCA GTGGCGGCAG TGGCAGTGGT 
GGGGAGAAGC CCAGCGGCCC TGTTCCCCGC AGCCGCCTGG ACCCCGCCAA GGTGCTGGGC 
ACTGCGCTGT GCCCGCGCAT CCACGAGGTG CCCCTGCTGG AGCCCCTTGT GTGCAAGAAG 
ATCGCCCAGG AGCGGCTCAC AGTCCTCCTG TTCCTGGAGG ACTGCATCAT CACTGCCTGC 
CAGGAGGGCC TCATCTGCAC CTGGGCCCGG CCGGGCAAGG CGTTCACAGA CGAGGAGACC 
GAGGCCCAGA CAGGGGAAGG AAGTTGGCCC AGGTCACCCA GCAAGTCAGT GGTAGAGGGC 
ATCTCCTCCC AACCAGGCAA CTCCCCGAGT GGCACAGTGG TGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Myotonic dystrophy type 1: role of CCG, CTC and CGG interruptions within DMPK alleles in the pathogenesis and molecular diagnosis.
Clinical genetics92(4)355-364(2017 Oct)
Santoro M,Masciullo M,Silvestri G,Novelli G,Botta A

A germline-specific class of small RNAs binds mammalian Piwi proteins.
Nature442(7099)199-202(2006 Jul)
Girard A,Sachidanandam R,Hannon GJ,Carmell MA

Large-scale characterization of HeLa cell nuclear phosphoproteins.
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DMWD cDNA ORF clone, Homo sapiens(human)

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