DLX6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DLX6
Entrez Gene ID	1750
Full Name	distal-less homeobox 6
General protein information	Preferred Names distal-less homeobox 6 Names homeobox protein DLX-6 distal-less homeo box 6
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q21.3
Summary	This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. This family is comprised of at least 6 different members that encode proteins with roles in forebrain and craniofacial development. This gene is in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7. [provided by RefSeq, Jul 2008].
Disorder MIM:	600030

mRNA and Protein(s)

mRNA	Protein	Name
NM_005222.4	NP_005213.3	homeobox protein DLX-6
NM_005222.3	NP_005213.3	homeobox protein DLX-6

Pathways from BioSystems

Homologies

Bos taurus (cattle)	DLX6	XP_002686712.2
Danio rerio (zebrafish)	dlx6a	NP_571398.1
Gallus gallus (chicken)	DLX6	NP_001074359.1
Mus musculus (house mouse)	Dlx6	NP_034187.1
Homo sapiens (human)	DLX6	NP_005213.3
Canis lupus familiaris (dog)	DLX6	XP_539429.3
Xenopus tropicalis (tropical clawed frog)	LOC100494171	XP_002935758.2
Pan troglodytes (chimpanzee)	DLX6	NP_001238818.1
	DLX6	XP_001090683.1
Rattus norvegicus (Norway rat)	Dlx6	XP_006236149.1

Gene Ontology
Bibliography

Related articles in PubMed

Long non-coding RNA DLX6-AS1 aggravates hepatocellular carcinoma carcinogenesis by modulating miR-203a/MMP-2 pathway.
Zhang L, He X, Jin T, Gang L, Jin Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie96884-891(2017 Dec)

Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I.
Rattanasopha S, Tongkobpetch S, Srichomthong C, Kitidumrongsook P, Suphapeetiporn K, Shotelersuk V
Journal of medical genetics51(12)817-23(2014 Dec)

Next generation sequencing of chromosomal rearrangements in patients with split-hand/split-foot malformation provides evidence for DYNC1I1 exonic enhancers of DLX5/6 expression in humans.
Lango Allen H, Caswell R, Xie W, Xu X, Wragg C, Turnpenny PD, Turner CL, Weedon MN, Ellard S
Journal of medical genetics51(4)264-7(2014 Apr)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I.
Title: Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I.

Genome sequencing of the deletion breakpoints showed that the DLX5 and DLX6 genes are disomic but the putative DYNC1I1 exon 15 and 17 enhancers are deleted.
Title: Next generation sequencing of chromosomal rearrangements in patients with split-hand/split-foot malformation provides evidence for DYNC1I1 exonic enhancers of DLX5/6 expression in humans.

The duplicated region harbors only DLX5 and DLX6, which are known for their role in SHFM1.
Title: A 0.7?Mb de novo duplication at 7q21.3 including the genes DLX5 and DLX6 in a patient with split-hand/split-foot malformation.

Two patients that have in common a p63-Dlx5/Dlx6 pathway dysregulation.
Title: Rapp-Hodgkin syndrome and SHFM1 patients: delineating the p63-Dlx5/Dlx6 pathway.

MDA-MB-231 breast neoplasms did not express DLX6 but the resulting bone/lung metastases did.
Title: Mutually exclusive expression of DLX2 and DLX5/6 is associated with the metastatic potential of the human breast cancer cell line MDA-MB-231.

The following DLX6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DLX6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu01620	NM_005222.4 Latest version!	Homo sapiens distal-less homeobox 6 (DLX6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu01620	NM_005222.3	Homo sapiens distal-less homeobox 6 (DLX6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DLX6 ( NM_005222.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_005213.3 Homo sapiens distal-less homeobox 6 (DLX6), mRNA.

Price & Availability↑

CloneID	OHu01620
Clone ID Related Accession (Same CDS sequence)	NM_005222.4 , NM_005222.3
Accession Version	NM_005222.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-06-03
Organism	Homo sapiens(human)
Product	homeobox protein DLX-6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004774.1, AK094086.1 and BU616500.1. On Nov 22, 2018 this sequence version replaced NM_005222.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.234367.1, SRR1803615.220668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000518156.3/ ENSP00000428480.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGATGACCA TGACTACGAT GGCTGACGGC TTGGAAGGCC AGGACTCGTC CAAATCCGCC 
TTCATGGAGT TCGGGCAGCA GCAGCAGCAG CAGCAGCAAC AGCAGCAGCA GCAGCAGCAG 
CAACAGCAAC AGCCGCCGCC GCCGCCGCCG CCGCCGCCGC AGCCGCACTC GCAGCAGAGC 
TCCCCGGCCA TGGCAGGCGC GCACTACCCT CTGCACTGCC TGCACTCGGC GGCGGCGGCG 
GCAGCGGCCG GCTCGCACCA CCACCACCAC CACCAGCACC ACCACCACGG CTCGCCCTAC 
GCGTCGGGCG GAGGGAACTC CTACAACCAC CGCTCGCTCG CCGCCTACCC CTACATGAGC 
CACTCGCAGC ACAGCCCTTA CCTCCAGTCC TACCACAACA GCAGCGCAGC CGCCCAGACG 
CGAGGGGACG ACACAGATCA ACAAAAAACT ACAGTGATTG AAAACGGGGA AATCAGGTTC 
AATGGAAAAG GGAAAAAGAT TCGGAAGCCT CGGACCATTT ATTCCAGCCT GCAGCTCCAG 
GCTTTAAACC ATCGCTTTCA GCAGACACAG TATCTGGCCC TTCCAGAGAG AGCCGAACTG 
GCAGCTTCCT TAGGACTGAC ACAAACACAG GTGAAGATAT GGTTTCAGAA CAAACGCTCT 
AAGTTTAAGA AACTGCTGAA GCAGGGCAGT AATCCTCATG AGAGCGACCC CCTCCAGGGC 
TCGGCGGCCC TGTCGCCACG CTCGCCAGCG CTGCCTCCAG TCTGGGACGT TTCTGCCTCG 
GCCAAGGGTG TCAGTATGCC CCCCAACAGC TACATGCCTG GCTATTCTCA CTGGTACTCC 
TCTCCACACC AGGACACGAT GCAGAGACCA CAGATGATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005213.3
CDS	426..1307
Translation	MMTMTTMADGLEGQDSSKSAFMEFGQQQQQQQQQQQQQQQQQQQPPPPPPPPPQPHSQQSSPAMAGAHYPLHCLHSAAAAAAAGSHHHHHHQHHHHGSPYASGGGNSYNHRSLAAYPYMSHSQHSPYLQSYHNSSAAAQTRGDDTDQQKTTVIENGEIRFNGKGKKIRKPRTIYSSLQLQALNHRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLLKQGSNPHESDPLQGSAALSPRSPALPPVWDVSASAKGVSMPPNSYMPGYSHWYSSPHQDTMQRPQMM

Target ORF information:

RefSeq Version	NM_005222.4
Organism	Homo sapiens(human)
Definition	Homo sapiens distal-less homeobox 6 (DLX6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005222.4

ORF Insert Sequence:

ATGATGACCA TGACTACGAT GGCTGACGGC TTGGAAGGCC AGGACTCGTC CAAATCCGCC 
TTCATGGAGT TCGGGCAGCA GCAGCAGCAG CAGCAGCAAC AGCAGCAGCA GCAGCAGCAG 
CAACAGCAAC AGCCGCCGCC GCCGCCGCCG CCGCCGCCGC AGCCGCACTC GCAGCAGAGC 
TCCCCGGCCA TGGCAGGCGC GCACTACCCT CTGCACTGCC TGCACTCGGC GGCGGCGGCG 
GCAGCGGCCG GCTCGCACCA CCACCACCAC CACCAGCACC ACCACCACGG CTCGCCCTAC 
GCGTCGGGCG GAGGGAACTC CTACAACCAC CGCTCGCTCG CCGCCTACCC CTACATGAGC 
CACTCGCAGC ACAGCCCTTA CCTCCAGTCC TACCACAACA GCAGCGCAGC CGCCCAGACG 
CGAGGGGACG ACACAGATCA ACAAAAAACT ACAGTGATTG AAAACGGGGA AATCAGGTTC 
AATGGAAAAG GGAAAAAGAT TCGGAAGCCT CGGACCATTT ATTCCAGCCT GCAGCTCCAG 
GCTTTAAACC ATCGCTTTCA GCAGACACAG TATCTGGCCC TTCCAGAGAG AGCCGAACTG 
GCAGCTTCCT TAGGACTGAC ACAAACACAG GTGAAGATAT GGTTTCAGAA CAAACGCTCT 
AAGTTTAAGA AACTGCTGAA GCAGGGCAGT AATCCTCATG AGAGCGACCC CCTCCAGGGC 
TCGGCGGCCC TGTCGCCACG CTCGCCAGCG CTGCCTCCAG TCTGGGACGT TTCTGCCTCG 
GCCAAGGGTG TCAGTATGCC CCCCAACAGC TACATGCCTG GCTATTCTCA CTGGTACTCC 
TCTCCACACC AGGACACGAT GCAGAGACCA CAGATGATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLX6 ( NM_005222.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005213.3 Homo sapiens distal-less homeobox 6 (DLX6), mRNA.

Price & Availability↑

CloneID	OHu01620
Clone ID Related Accession (Same CDS sequence)	NM_005222.4 , NM_005222.3
Accession Version	NM_005222.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 882bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	homeobox protein DLX-6
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC004774.1, AK094086.1 and BU616500.1. On Apr 13, 2010 this sequence version replaced NM_005222.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660809.234367.1, SRR1803615.220668.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGATGACCA TGACTACGAT GGCTGACGGC TTGGAAGGCC AGGACTCGTC CAAATCCGCC 
TTCATGGAGT TCGGGCAGCA GCAGCAGCAG CAGCAGCAAC AGCAGCAGCA GCAGCAGCAG 
CAACAGCAAC AGCCGCCGCC GCCGCCGCCG CCGCCGCCGC AGCCGCACTC GCAGCAGAGC 
TCCCCGGCCA TGGCAGGCGC GCACTACCCT CTGCACTGCC TGCACTCGGC GGCGGCGGCG 
GCAGCGGCCG GCTCGCACCA CCACCACCAC CACCAGCACC ACCACCACGG CTCGCCCTAC 
GCGTCGGGCG GAGGGAACTC CTACAACCAC CGCTCGCTCG CCGCCTACCC CTACATGAGC 
CACTCGCAGC ACAGCCCTTA CCTCCAGTCC TACCACAACA GCAGCGCAGC CGCCCAGACG 
CGAGGGGACG ACACAGATCA ACAAAAAACT ACAGTGATTG AAAACGGGGA AATCAGGTTC 
AATGGAAAAG GGAAAAAGAT TCGGAAGCCT CGGACCATTT ATTCCAGCCT GCAGCTCCAG 
GCTTTAAACC ATCGCTTTCA GCAGACACAG TATCTGGCCC TTCCAGAGAG AGCCGAACTG 
GCAGCTTCCT TAGGACTGAC ACAAACACAG GTGAAGATAT GGTTTCAGAA CAAACGCTCT 
AAGTTTAAGA AACTGCTGAA GCAGGGCAGT AATCCTCATG AGAGCGACCC CCTCCAGGGC 
TCGGCGGCCC TGTCGCCACG CTCGCCAGCG CTGCCTCCAG TCTGGGACGT TTCTGCCTCG 
GCCAAGGGTG TCAGTATGCC CCCCAACAGC TACATGCCTG GCTATTCTCA CTGGTACTCC 
TCTCCACACC AGGACACGAT GCAGAGACCA CAGATGATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005213.3
CDS	1..882
Translation	MMTMTTMADGLEGQDSSKSAFMEFGQQQQQQQQQQQQQQQQQQQPPPPPPPPPQPHSQQSSPAMAGAHYPLHCLHSAAAAAAAGSHHHHHHQHHHHGSPYASGGGNSYNHRSLAAYPYMSHSQHSPYLQSYHNSSAAAQTRGDDTDQQKTTVIENGEIRFNGKGKKIRKPRTIYSSLQLQALNHRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLLKQGSNPHESDPLQGSAALSPRSPALPPVWDVSASAKGVSMPPNSYMPGYSHWYSSPHQDTMQRPQMM

Target ORF information:

RefSeq Version	NM_005222.3
Organism	Homo sapiens(human)
Definition	Homo sapiens distal-less homeobox 6 (DLX6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005222.3

ORF Insert Sequence:

ATGATGACCA TGACTACGAT GGCTGACGGC TTGGAAGGCC AGGACTCGTC CAAATCCGCC 
TTCATGGAGT TCGGGCAGCA GCAGCAGCAG CAGCAGCAAC AGCAGCAGCA GCAGCAGCAG 
CAACAGCAAC AGCCGCCGCC GCCGCCGCCG CCGCCGCCGC AGCCGCACTC GCAGCAGAGC 
TCCCCGGCCA TGGCAGGCGC GCACTACCCT CTGCACTGCC TGCACTCGGC GGCGGCGGCG 
GCAGCGGCCG GCTCGCACCA CCACCACCAC CACCAGCACC ACCACCACGG CTCGCCCTAC 
GCGTCGGGCG GAGGGAACTC CTACAACCAC CGCTCGCTCG CCGCCTACCC CTACATGAGC 
CACTCGCAGC ACAGCCCTTA CCTCCAGTCC TACCACAACA GCAGCGCAGC CGCCCAGACG 
CGAGGGGACG ACACAGATCA ACAAAAAACT ACAGTGATTG AAAACGGGGA AATCAGGTTC 
AATGGAAAAG GGAAAAAGAT TCGGAAGCCT CGGACCATTT ATTCCAGCCT GCAGCTCCAG 
GCTTTAAACC ATCGCTTTCA GCAGACACAG TATCTGGCCC TTCCAGAGAG AGCCGAACTG 
GCAGCTTCCT TAGGACTGAC ACAAACACAG GTGAAGATAT GGTTTCAGAA CAAACGCTCT 
AAGTTTAAGA AACTGCTGAA GCAGGGCAGT AATCCTCATG AGAGCGACCC CCTCCAGGGC 
TCGGCGGCCC TGTCGCCACG CTCGCCAGCG CTGCCTCCAG TCTGGGACGT TTCTGCCTCG 
GCCAAGGGTG TCAGTATGCC CCCCAACAGC TACATGCCTG GCTATTCTCA CTGGTACTCC 
TCTCCACACC AGGACACGAT GCAGAGACCA CAGATGATGT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Long non-coding RNA DLX6-AS1 aggravates hepatocellular carcinoma carcinogenesis by modulating miR-203a/MMP-2 pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie96884-891(2017 Dec)
Zhang L,He X,Jin T,Gang L,Jin Z

Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I.
Journal of medical genetics51(12)817-23(2014 Dec)
Rattanasopha S,Tongkobpetch S,Srichomthong C,Kitidumrongsook P,Suphapeetiporn K,Shotelersuk V

Next generation sequencing of chromosomal rearrangements in patients with split-hand/split-foot malformation provides evidence for DYNC1I1 exonic enhancers of DLX5/6 expression in humans.
Journal of medical genetics51(4)264-7(2014 Apr)
Lango Allen H,Caswell R,Xie W,Xu X,Wragg C,Turnpenny PD,Turner CL,Weedon MN,Ellard S

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DLX6 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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