DLX5 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DLX5
Entrez Gene ID	1749
Full Name	distal-less homeobox 5
Synonyms	SHFM1D
General protein information	Preferred Names distal-less homeobox 5 Names homeobox protein DLX-5 distal-less homeo box 5 split hand/foot malformation type 1 with sensorineural hearing loss
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q21.3
Summary	This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein may play a role in bone development and fracture healing. Mutation in this gene, which is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 7, may be associated with split-hand/split-foot malformation. [provided by RefSeq, Jul 2008].
Disorder MIM:	600028
Disorder Html:	?Split-hand/foot malformation 1 with sensorineural hearing loss, 220600 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005221.5	NP_005212.1	homeobox protein DLX-5
XM_005250185.3	XP_005250242.1	homeobox protein DLX-5 isoform X1
NM_005221.6	NP_005212.1	homeobox protein DLX-5
XM_017011803.1	XP_016867292.1	homeobox protein DLX-5 isoform X1

Pathways from BioSystems

Homologies

	DLX5	XP_001090332.1
Gallus gallus (chicken)	DLX5	NP_989490.1
Pan troglodytes (chimpanzee)	DLX5	XP_519218.2
Mus musculus (house mouse)	Dlx5	NP_034186.2
Danio rerio (zebrafish)	dlx5a	NP_571381.1
Canis lupus familiaris (dog)	DLX5	XP_850412.1
Homo sapiens (human)	DLX5	NP_005212.1
Bos taurus (cattle)	DLX5	NP_001068781.1
Rattus norvegicus (Norway rat)	Dlx5	NP_037075.1
Xenopus tropicalis (tropical clawed frog)	dlx5	NP_001004778.1

Gene Ontology
Bibliography

Related articles in PubMed

Deletion of a Long-Range
Johnson KR, Gagnon LH, Tian C, Longo-Guess CM, Low BE, Wiles MV, Kiernan AE
Genetics(2018 Jan)

Distal-less homeobox 5 is a master regulator of the osteogenesis of human mesenchymal stem cells.
Heo JS, Lee SG, Kim HO
International journal of molecular medicine40(5)1486-1494(2017 Nov)

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker.
Zadora J, Singh M, Herse F, Przybyl L, Haase N, Golic M, Yung HW, Huppertz B, Cartwright JE, Whitley G, Johnsen GM, Levi G, Isbruch A, Schulz H, Luft FC, M?ller DN, Staff AC, Hurst LD, Dechend R, Izsv?k Z
Circulation136(19)1824-1839(2017 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

As a result of disturbed imprinting, the upregulated DLX5 affects trophoblast proliferation in preeclampsia.
Title: Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker.

These data indicate that certain missense mutations diminish the ability of the Dlx5 homeodomain to recognize and bind target DNAs, and they likely destabilize the formation of functional complexes.
Title: Dlx5 Homeodomain:DNA Complex: Structure, Binding and Effect of Mutations Related to Split Hand and Foot Malformation Syndrome.

Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I.
Title: Absent expression of the osteoblast-specific maternally imprinted genes, DLX5 and DLX6, causes split hand/split foot malformation type I.

Heterozygous DLX5 nonsense mutation c.G115T(p.E39X) associated with isolated split-hand/foot malformation with reduced penetrance and variable expressivity in two unrelated Polish families.
Title: Heterozygous DLX5 nonsense mutation associated with isolated split-hand/foot malformation with reduced penetrance and variable expressivity in two unrelated families.

In cells grown on titanium support, DLX5 and RUNX1 were respectively upregulated (+3.12-fold) and downregulated (-2.14-fold)
Title: Expression of SP7, RUNX1, DLX5, and CTNNB1 in human mesenchymal stem cells cultured on xenogeneic bone substitute as compared with machined titanium.

The following DLX5 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DLX5 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18344	NM_005221.6 Latest version!	Homo sapiens distal-less homeobox 5 (DLX5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu41401	XM_005250185.3 Latest version!	Homo sapiens distal-less homeobox 5 (DLX5), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
OHu41401	XM_017011803.1 Latest version!	Homo sapiens distal-less homeobox 5 (DLX5), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu18344	NM_005221.5	Homo sapiens distal-less homeobox 5 (DLX5), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DLX5 ( NM_005221.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_005212.1 Homo sapiens distal-less homeobox 5 (DLX5), mRNA.

Price & Availability↑

CloneID	OHu18344
Clone ID Related Accession (Same CDS sequence)	NM_005221.5 , NM_005221.6
Accession Version	NM_005221.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-11-26
Organism	Homo sapiens(human)
Product	homeobox protein DLX-5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB280023.1, BC006226.2 and AA129308.1. This sequence is a reference standard in the RefSeqGene project. On Dec 29, 2005 this sequence version replaced NM_005221.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK023493.1, BC006226.2 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267768 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACAGGAG TGTTTGACAG AAGGGTCCCC AGCATCCGAT CCGGCGACTT CCAAGCTCCG 
TTCCAGACGT CCGCAGCTAT GCACCATCCG TCTCAGGAAT CGCCAACTTT GCCCGAGTCT 
TCAGCTACCG ATTCTGACTA CTACAGCCCT ACGGGGGGAG CCCCGCACGG CTACTGCTCT 
CCTACCTCGG CTTCCTATGG CAAAGCTCTC AACCCCTACC AGTATCAGTA TCACGGCGTG 
AACGGCTCCG CCGGGAGCTA CCCAGCCAAA GCTTATGCCG ACTATAGCTA CGCTAGCTCC 
TACCACCAGT ACGGCGGCGC CTACAACCGC GTCCCAAGCG CCACCAACCA GCCAGAGAAA 
GAAGTGACCG AGCCCGAGGT GAGAATGGTG AATGGCAAAC CAAAGAAAGT TCGTAAACCC 
AGGACTATTT ATTCCAGCTT TCAGCTGGCC GCATTACAGA GAAGGTTTCA GAAGACTCAG 
TACCTCGCCT TGCCGGAACG CGCCGAGCTG GCCGCCTCGC TGGGATTGAC ACAAACACAG 
GTGAAAATCT GGTTTCAGAA CAAAAGATCC AAGATCAAGA AGATCATGAA AAACGGGGAG 
ATGCCCCCGG AGCACAGTCC CAGCTCCAGC GACCCAATGG CGTGTAACTC GCCGCAGTCT 
CCAGCGGTGT GGGAGCCCCA GGGCTCGTCC CGCTCGCTCA GCCACCACCC TCATGCCCAC 
CCTCCGACCT CCAACCAGTC CCCAGCGTCC AGCTACCTGG AGAACTCTGC ATCCTGGTAC 
ACAAGTGCAG CCAGCTCAAT CAATTCCCAC CTGCCGCCGC CGGGCTCCTT ACAGCACCCG 
CTGGCGCTGG CCTCCGGGAC ACTCTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005212.1
CDS	209..1078
Translation	MTGVFDRRVPSIRSGDFQAPFQTSAAMHHPSQESPTLPESSATDSDYYSPTGGAPHGYCSPTSASYGKALNPYQYQYHGVNGSAGSYPAKAYADYSYASSYHQYGGAYNRVPSATNQPEKEVTEPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNKRSKIKKIMKNGEMPPEHSPSSSDPMACNSPQSPAVWEPQGSSRSLSHHPHAHPPTSNQSPASSYLENSASWYTSAASSINSHLPPPGSLQHPLALASGTLY

Target ORF information:

RefSeq Version	NM_005221.5
Organism	Homo sapiens(human)
Definition	Homo sapiens distal-less homeobox 5 (DLX5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005221.5

ORF Insert Sequence:

ATGACAGGAG TGTTTGACAG AAGGGTCCCC AGCATCCGAT CCGGCGACTT CCAAGCTCCG 
TTCCAGACGT CCGCAGCTAT GCACCATCCG TCTCAGGAAT CGCCAACTTT GCCCGAGTCT 
TCAGCTACCG ATTCTGACTA CTACAGCCCT ACGGGGGGAG CCCCGCACGG CTACTGCTCT 
CCTACCTCGG CTTCCTATGG CAAAGCTCTC AACCCCTACC AGTATCAGTA TCACGGCGTG 
AACGGCTCCG CCGGGAGCTA CCCAGCCAAA GCTTATGCCG ACTATAGCTA CGCTAGCTCC 
TACCACCAGT ACGGCGGCGC CTACAACCGC GTCCCAAGCG CCACCAACCA GCCAGAGAAA 
GAAGTGACCG AGCCCGAGGT GAGAATGGTG AATGGCAAAC CAAAGAAAGT TCGTAAACCC 
AGGACTATTT ATTCCAGCTT TCAGCTGGCC GCATTACAGA GAAGGTTTCA GAAGACTCAG 
TACCTCGCCT TGCCGGAACG CGCCGAGCTG GCCGCCTCGC TGGGATTGAC ACAAACACAG 
GTGAAAATCT GGTTTCAGAA CAAAAGATCC AAGATCAAGA AGATCATGAA AAACGGGGAG 
ATGCCCCCGG AGCACAGTCC CAGCTCCAGC GACCCAATGG CGTGTAACTC GCCGCAGTCT 
CCAGCGGTGT GGGAGCCCCA GGGCTCGTCC CGCTCGCTCA GCCACCACCC TCATGCCCAC 
CCTCCGACCT CCAACCAGTC CCCAGCGTCC AGCTACCTGG AGAACTCTGC ATCCTGGTAC 
ACAAGTGCAG CCAGCTCAAT CAATTCCCAC CTGCCGCCGC CGGGCTCCTT ACAGCACCCG 
CTGGCGCTGG CCTCCGGGAC ACTCTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLX5 ( NM_005221.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_005212.1 Homo sapiens distal-less homeobox 5 (DLX5), mRNA.

Price & Availability↑

CloneID	OHu18344
Clone ID Related Accession (Same CDS sequence)	NM_005221.5 , NM_005221.6
Accession Version	NM_005221.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 870bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	homeobox protein DLX-5
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB280023.1 and BC006226.2. This sequence is a reference standard in the RefSeqGene project. On Aug 31, 2018 this sequence version replaced NM_005221.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC006226.2, AK023493.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03267768 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000648378.1/ ENSP00000498116.1 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACAGGAG TGTTTGACAG AAGGGTCCCC AGCATCCGAT CCGGCGACTT CCAAGCTCCG 
TTCCAGACGT CCGCAGCTAT GCACCATCCG TCTCAGGAAT CGCCAACTTT GCCCGAGTCT 
TCAGCTACCG ATTCTGACTA CTACAGCCCT ACGGGGGGAG CCCCGCACGG CTACTGCTCT 
CCTACCTCGG CTTCCTATGG CAAAGCTCTC AACCCCTACC AGTATCAGTA TCACGGCGTG 
AACGGCTCCG CCGGGAGCTA CCCAGCCAAA GCTTATGCCG ACTATAGCTA CGCTAGCTCC 
TACCACCAGT ACGGCGGCGC CTACAACCGC GTCCCAAGCG CCACCAACCA GCCAGAGAAA 
GAAGTGACCG AGCCCGAGGT GAGAATGGTG AATGGCAAAC CAAAGAAAGT TCGTAAACCC 
AGGACTATTT ATTCCAGCTT TCAGCTGGCC GCATTACAGA GAAGGTTTCA GAAGACTCAG 
TACCTCGCCT TGCCGGAACG CGCCGAGCTG GCCGCCTCGC TGGGATTGAC ACAAACACAG 
GTGAAAATCT GGTTTCAGAA CAAAAGATCC AAGATCAAGA AGATCATGAA AAACGGGGAG 
ATGCCCCCGG AGCACAGTCC CAGCTCCAGC GACCCAATGG CGTGTAACTC GCCGCAGTCT 
CCAGCGGTGT GGGAGCCCCA GGGCTCGTCC CGCTCGCTCA GCCACCACCC TCATGCCCAC 
CCTCCGACCT CCAACCAGTC CCCAGCGTCC AGCTACCTGG AGAACTCTGC ATCCTGGTAC 
ACAAGTGCAG CCAGCTCAAT CAATTCCCAC CTGCCGCCGC CGGGCTCCTT ACAGCACCCG 
CTGGCGCTGG CCTCCGGGAC ACTCTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005212.1
CDS	209..1078
Translation	MTGVFDRRVPSIRSGDFQAPFQTSAAMHHPSQESPTLPESSATDSDYYSPTGGAPHGYCSPTSASYGKALNPYQYQYHGVNGSAGSYPAKAYADYSYASSYHQYGGAYNRVPSATNQPEKEVTEPEVRMVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNKRSKIKKIMKNGEMPPEHSPSSSDPMACNSPQSPAVWEPQGSSRSLSHHPHAHPPTSNQSPASSYLENSASWYTSAASSINSHLPPPGSLQHPLALASGTLY

Target ORF information:

RefSeq Version	NM_005221.6
Organism	Homo sapiens(human)
Definition	Homo sapiens distal-less homeobox 5 (DLX5), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005221.6

ORF Insert Sequence:

ATGACAGGAG TGTTTGACAG AAGGGTCCCC AGCATCCGAT CCGGCGACTT CCAAGCTCCG 
TTCCAGACGT CCGCAGCTAT GCACCATCCG TCTCAGGAAT CGCCAACTTT GCCCGAGTCT 
TCAGCTACCG ATTCTGACTA CTACAGCCCT ACGGGGGGAG CCCCGCACGG CTACTGCTCT 
CCTACCTCGG CTTCCTATGG CAAAGCTCTC AACCCCTACC AGTATCAGTA TCACGGCGTG 
AACGGCTCCG CCGGGAGCTA CCCAGCCAAA GCTTATGCCG ACTATAGCTA CGCTAGCTCC 
TACCACCAGT ACGGCGGCGC CTACAACCGC GTCCCAAGCG CCACCAACCA GCCAGAGAAA 
GAAGTGACCG AGCCCGAGGT GAGAATGGTG AATGGCAAAC CAAAGAAAGT TCGTAAACCC 
AGGACTATTT ATTCCAGCTT TCAGCTGGCC GCATTACAGA GAAGGTTTCA GAAGACTCAG 
TACCTCGCCT TGCCGGAACG CGCCGAGCTG GCCGCCTCGC TGGGATTGAC ACAAACACAG 
GTGAAAATCT GGTTTCAGAA CAAAAGATCC AAGATCAAGA AGATCATGAA AAACGGGGAG 
ATGCCCCCGG AGCACAGTCC CAGCTCCAGC GACCCAATGG CGTGTAACTC GCCGCAGTCT 
CCAGCGGTGT GGGAGCCCCA GGGCTCGTCC CGCTCGCTCA GCCACCACCC TCATGCCCAC 
CCTCCGACCT CCAACCAGTC CCCAGCGTCC AGCTACCTGG AGAACTCTGC ATCCTGGTAC 
ACAAGTGCAG CCAGCTCAAT CAATTCCCAC CTGCCGCCGC CGGGCTCCTT ACAGCACCCG 
CTGGCGCTGG CCTCCGGGAC ACTCTATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLX5 ( XM_005250185.3 ) cDNA ORF clone, Homo sapiens(human) -> XP_005250242.1 Homo sapiens distal-less homeobox 5 (DLX5), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu41401
Clone ID Related Accession (Same CDS sequence)	XM_005250185.3 , XM_017011803.1
Accession Version	XM_005250185.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	homeobox protein DLX-5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_005250185.2. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGAATG GCAAACCAAA GAAAGTTCGT AAACCCAGGA CTATTTATTC CAGCTTTCAG 
CTGGCCGCAT TACAGAGAAG GTTTCAGAAG ACTCAGTACC TCGCCTTGCC GGAACGCGCC 
GAGCTGGCCG CCTCGCTGGG ATTGACACAA ACACAGGTGA AAATCTGGTT TCAGAACAAA 
AGATCCAAGA TCAAGAAGAT CATGAAAAAC GGGGAGATGC CCCCGGAGCA CAGTCCCAGC 
TCCAGCGACC CAATGGCGTG TAACTCGCCG CAGTCTCCAG CGGTGTGGGA GCCCCAGGGC 
TCGTCCCGCT CGCTCAGCCA CCACCCTCAT GCCCACCCTC CGACCTCCAA CCAGTCCCCA 
GCGTCCAGCT ACCTGGAGAA CTCTGCATCC TGGTACACAA GTGCAGCCAG CTCAATCAAT 
TCCCACCTGC CGCCGCCGGG CTCCTTACAG CACCCGCTGG CGCTGGCCTC CGGGACACTC 
TATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_005250242.1
CDS	1704..2189
Translation	MVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNKRSKIKKIMKNGEMPPEHSPSSSDPMACNSPQSPAVWEPQGSSRSLSHHPHAHPPTSNQSPASSYLENSASWYTSAASSINSHLPPPGSLQHPLALASGTLY

Target ORF information:

RefSeq Version	XM_005250185.3
Organism	Homo sapiens(human)
Definition	Homo sapiens distal-less homeobox 5 (DLX5), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_005250185.3

ORF Insert Sequence:

ATGGTGAATG GCAAACCAAA GAAAGTTCGT AAACCCAGGA CTATTTATTC CAGCTTTCAG 
CTGGCCGCAT TACAGAGAAG GTTTCAGAAG ACTCAGTACC TCGCCTTGCC GGAACGCGCC 
GAGCTGGCCG CCTCGCTGGG ATTGACACAA ACACAGGTGA AAATCTGGTT TCAGAACAAA 
AGATCCAAGA TCAAGAAGAT CATGAAAAAC GGGGAGATGC CCCCGGAGCA CAGTCCCAGC 
TCCAGCGACC CAATGGCGTG TAACTCGCCG CAGTCTCCAG CGGTGTGGGA GCCCCAGGGC 
TCGTCCCGCT CGCTCAGCCA CCACCCTCAT GCCCACCCTC CGACCTCCAA CCAGTCCCCA 
GCGTCCAGCT ACCTGGAGAA CTCTGCATCC TGGTACACAA GTGCAGCCAG CTCAATCAAT 
TCCCACCTGC CGCCGCCGGG CTCCTTACAG CACCCGCTGG CGCTGGCCTC CGGGACACTC 
TATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLX5 ( XM_017011803.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016867292.1 Homo sapiens distal-less homeobox 5 (DLX5), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu41401
Clone ID Related Accession (Same CDS sequence)	XM_005250185.3 , XM_017011803.1
Accession Version	XM_017011803.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 486bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	homeobox protein DLX-5 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000007.14) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGTGAATG GCAAACCAAA GAAAGTTCGT AAACCCAGGA CTATTTATTC CAGCTTTCAG 
CTGGCCGCAT TACAGAGAAG GTTTCAGAAG ACTCAGTACC TCGCCTTGCC GGAACGCGCC 
GAGCTGGCCG CCTCGCTGGG ATTGACACAA ACACAGGTGA AAATCTGGTT TCAGAACAAA 
AGATCCAAGA TCAAGAAGAT CATGAAAAAC GGGGAGATGC CCCCGGAGCA CAGTCCCAGC 
TCCAGCGACC CAATGGCGTG TAACTCGCCG CAGTCTCCAG CGGTGTGGGA GCCCCAGGGC 
TCGTCCCGCT CGCTCAGCCA CCACCCTCAT GCCCACCCTC CGACCTCCAA CCAGTCCCCA 
GCGTCCAGCT ACCTGGAGAA CTCTGCATCC TGGTACACAA GTGCAGCCAG CTCAATCAAT 
TCCCACCTGC CGCCGCCGGG CTCCTTACAG CACCCGCTGG CGCTGGCCTC CGGGACACTC 
TATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016867292.1
CDS	94..579
Translation	MVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNKRSKIKKIMKNGEMPPEHSPSSSDPMACNSPQSPAVWEPQGSSRSLSHHPHAHPPTSNQSPASSYLENSASWYTSAASSINSHLPPPGSLQHPLALASGTLY

Target ORF information:

RefSeq Version	XM_017011803.1
Organism	Homo sapiens(human)
Definition	Homo sapiens distal-less homeobox 5 (DLX5), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017011803.1

ORF Insert Sequence:

ATGGTGAATG GCAAACCAAA GAAAGTTCGT AAACCCAGGA CTATTTATTC CAGCTTTCAG 
CTGGCCGCAT TACAGAGAAG GTTTCAGAAG ACTCAGTACC TCGCCTTGCC GGAACGCGCC 
GAGCTGGCCG CCTCGCTGGG ATTGACACAA ACACAGGTGA AAATCTGGTT TCAGAACAAA 
AGATCCAAGA TCAAGAAGAT CATGAAAAAC GGGGAGATGC CCCCGGAGCA CAGTCCCAGC 
TCCAGCGACC CAATGGCGTG TAACTCGCCG CAGTCTCCAG CGGTGTGGGA GCCCCAGGGC 
TCGTCCCGCT CGCTCAGCCA CCACCCTCAT GCCCACCCTC CGACCTCCAA CCAGTCCCCA 
GCGTCCAGCT ACCTGGAGAA CTCTGCATCC TGGTACACAA GTGCAGCCAG CTCAATCAAT 
TCCCACCTGC CGCCGCCGGG CTCCTTACAG CACCCGCTGG CGCTGGCCTC CGGGACACTC 
TATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Deletion of a Long-Range
Genetics(2018 Jan)
Johnson KR,Gagnon LH,Tian C,Longo-Guess CM,Low BE,Wiles MV,Kiernan AE

Distal-less homeobox 5 is a master regulator of the osteogenesis of human mesenchymal stem cells.
International journal of molecular medicine40(5)1486-1494(2017 Nov)
Heo JS,Lee SG,Kim HO

Disturbed Placental Imprinting in Preeclampsia Leads to Altered Expression of DLX5, a Human-Specific Early Trophoblast Marker.
Circulation136(19)1824-1839(2017 Nov)
Zadora J,Singh M,Herse F,Przybyl L,Haase N,Golic M,Yung HW,Huppertz B,Cartwright JE,Whitley G,Johnsen GM,Levi G,Isbruch A,Schulz H,Luft FC,M?ller DN,Staff AC,Hurst LD,Dechend R,Izsv?k Z

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DLX5 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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