DLX3 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DLX3
Entrez Gene ID	1747
Full Name	distal-less homeobox 3
Synonyms	AI4,TDO
General protein information	Preferred Names distal-less homeobox 3 Names homeobox protein DLX-3
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.33
Summary	Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. Trichodentoosseous syndrome (TDO), an autosomal dominant condition, has been correlated with DLX3 gene mutation. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 17. Mutations in this gene have been associated with the autosomal dominant conditions trichodentoosseous syndrome and amelogenesis imperfecta with taurodontism. [provided by RefSeq, Jul 2008].
Disorder MIM:	600525
Disorder Html:	Trichodontoosseous syndrome, 190320 (3); Amelogenesis imperfecta, type IV, 104510 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_005220.3	NP_005211.1	homeobox protein DLX-3
NM_005220.2	NP_005211.1	homeobox protein DLX-3

Pathways from BioSystems

Homologies

Mus musculus (house mouse)	Dlx3	NP_034185.1
Gallus gallus (chicken)	DLX3	NP_990135.1
	DLX3	XP_001095325.1
Rattus norvegicus (Norway rat)	Dlx3	NP_001099302.1
Pan troglodytes (chimpanzee)	DLX3	XP_511871.2
Bos taurus (cattle)	DLX3	NP_001075091.1
Homo sapiens (human)	DLX3	NP_005211.1
Canis lupus familiaris (dog)	DLX3	XP_548193.2
Danio rerio (zebrafish)	dlx3b	NP_571397.2
Xenopus tropicalis (tropical clawed frog)	dlx3	NP_001025566.1

Gene Ontology
Bibliography

Related articles in PubMed

Lack of Association between BMP2/DLX3 Gene Polymorphisms and Dental Caries in Primary and Permanent Dentitions.
Kastovsky J, Borilova Linhartova P, Musilova K, Zackova L, Kukletova M, Kukla L, Izakovicova Holla L
Caries research51(6)590-595(2017 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

DLX3 regulates bone marrow mesenchymal stem cell proliferation through H19/miR-675 axis.
Title: DLX3 promotes bone marrow mesenchymal stem cell proliferation through H19/miR-675 axis.

Identify a novel cis-acting sequence (-369 to -320) at the placental growth factor promoter, which was critical for mediating the basal and DLX3/GCM1-dependent PGF promoter activities.
Title: Dlx3 and GCM-1 functionally coordinate the regulation of placental growth factor in human trophoblast-derived cells.

We showed that the supplementation of the osteogenic differentiation medium with PTHrP inhibited the alkaline phosphatase activity and the expression of the transcription factor DLX3, but the depletion of PTHrP did not support the differentiation of DFCs.We showed that SUFU (Suppressor Of Fused Homolog) was not regulated during the osteogenic differentiation in DFCs
Title: The parathyroid hormone-related protein is secreted during the osteogenic differentiation of human dental follicle cells and inhibits the alkaline phosphatase activity and the expression of DLX3.

we identified a recurrent 2-bp deletion in the DLX3 gene in a new family and described their mild clinical phenotype related to the DLX3 mutation.
Title: Unexpected identification of a recurrent mutation in the DLX3 gene causing amelogenesis imperfecta.

ER-alpha regulates the osteoblast differentiation through modulation of Dlx3 expression and/or interaction with Dlx3.
Title: Estrogen Receptor ? Regulates Dlx3-Mediated Osteoblast Differentiation.

The following DLX3 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DLX3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18182	NM_005220.3 Latest version!	Homo sapiens distal-less homeobox 3 (DLX3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu18182	NM_005220.2	Homo sapiens distal-less homeobox 3 (DLX3), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$139.30 $199.00
Hide Old Accession Versions >>

ORF Online Only Promotion

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DLX3 ( NM_005220.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_005211.1 Homo sapiens distal-less homeobox 3 (DLX3), mRNA.

Price & Availability↑

CloneID	OHu18182
Clone ID Related Accession (Same CDS sequence)	NM_005220.3 , NM_005220.2
Accession Version	NM_005220.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 864bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	homeobox protein DLX-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC009720.19. On Nov 23, 2018 this sequence version replaced NM_005220.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313257.1, BC028970.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000434704.2/ ENSP00000389870.2 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGTGGCT CCTTCGATCG CAAGCTCAGC AGCATCCTCA CCGACATCTC CAGCTCCCTT 
AGCTGCCATG CGGGCTCCAA GGACTCGCCT ACCCTGCCCG AGTCTTCTGT CACTGACCTG 
GGCTACTACA GCGCTCCCCA GCACGATTAC TACTCGGGCC AGCCCTATGG CCAGACGGTG 
AACCCCTACA CCTACCACCA CCAATTCAAT CTCAATGGGC TTGCAGGCAC GGGCGCTTAC 
TCGCCCAAGT CGGAATATAC CTACGGAGCC TCCTACCGGC AATACGGGGC GTATCGGGAG 
CAGCCGCTGC CAGCCCAGGA CCCAGTGTCG GTGAAGGAGG AGCCGGAAGC AGAGGTGCGC 
ATGGTGAATG GGAAGCCCAA GAAGGTCCGA AAGCCGCGTA CGATCTACTC CAGCTACCAG 
CTGGCCGCCC TGCAGCGCCG CTTCCAGAAG GCCCAGTACC TGGCGCTGCC CGAGCGCGCC 
GAGCTGGCCG CGCAGCTGGG CCTCACGCAG ACACAGGTGA AAATCTGGTT CCAGAACCGC 
CGTTCCAAGT TCAAGAAACT CTACAAGAAC GGGGAGGTGC CGCTGGAGCA CAGTCCCAAT 
AACAGTGATT CCATGGCCTG CAACTCACCA CCATCACCCG CCCTCTGGGA CACCTCTTCC 
CACTCCACTC CGGCCCCTGC CCGCAGTCAG CTGCCCCCGC CGCTCCCATA CAGTGCCTCC 
CCCAGCTACC TGGACGACCC CACCAACTCC TGGTATCACG CACAGAACCT GAGTGGACCC 
CACTTACAGC AGCAGCCGCC TCAGCCAGCC ACCCTGCACC ATGCCTCTCC CGGGCCCCCG 
CCCAACCCTG GGGCTGTGTA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005211.1
CDS	227..1090
Translation	MSGSFDRKLSSILTDISSSLSCHAGSKDSPTLPESSVTDLGYYSAPQHDYYSGQPYGQTVNPYTYHHQFNLNGLAGTGAYSPKSEYTYGASYRQYGAYREQPLPAQDPVSVKEEPEAEVRMVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLYKNGEVPLEHSPNNSDSMACNSPPSPALWDTSSHSTPAPARSQLPPPLPYSASPSYLDDPTNSWYHAQNLSGPHLQQQPPQPATLHHASPGPPPNPGAVY

Target ORF information:

RefSeq Version	NM_005220.3
Organism	Homo sapiens(human)
Definition	Homo sapiens distal-less homeobox 3 (DLX3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005220.3

ORF Insert Sequence:

ATGAGTGGCT CCTTCGATCG CAAGCTCAGC AGCATCCTCA CCGACATCTC CAGCTCCCTT 
AGCTGCCATG CGGGCTCCAA GGACTCGCCT ACCCTGCCCG AGTCTTCTGT CACTGACCTG 
GGCTACTACA GCGCTCCCCA GCACGATTAC TACTCGGGCC AGCCCTATGG CCAGACGGTG 
AACCCCTACA CCTACCACCA CCAATTCAAT CTCAATGGGC TTGCAGGCAC GGGCGCTTAC 
TCGCCCAAGT CGGAATATAC CTACGGAGCC TCCTACCGGC AATACGGGGC GTATCGGGAG 
CAGCCGCTGC CAGCCCAGGA CCCAGTGTCG GTGAAGGAGG AGCCGGAAGC AGAGGTGCGC 
ATGGTGAATG GGAAGCCCAA GAAGGTCCGA AAGCCGCGTA CGATCTACTC CAGCTACCAG 
CTGGCCGCCC TGCAGCGCCG CTTCCAGAAG GCCCAGTACC TGGCGCTGCC CGAGCGCGCC 
GAGCTGGCCG CGCAGCTGGG CCTCACGCAG ACACAGGTGA AAATCTGGTT CCAGAACCGC 
CGTTCCAAGT TCAAGAAACT CTACAAGAAC GGGGAGGTGC CGCTGGAGCA CAGTCCCAAT 
AACAGTGATT CCATGGCCTG CAACTCACCA CCATCACCCG CCCTCTGGGA CACCTCTTCC 
CACTCCACTC CGGCCCCTGC CCGCAGTCAG CTGCCCCCGC CGCTCCCATA CAGTGCCTCC 
CCCAGCTACC TGGACGACCC CACCAACTCC TGGTATCACG CACAGAACCT GAGTGGACCC 
CACTTACAGC AGCAGCCGCC TCAGCCAGCC ACCCTGCACC ATGCCTCTCC CGGGCCCCCG 
CCCAACCCTG GGGCTGTGTA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLX3 ( NM_005220.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_005211.1 Homo sapiens distal-less homeobox 3 (DLX3), mRNA.

Price & Availability↑

CloneID	OHu18182
Clone ID Related Accession (Same CDS sequence)	NM_005220.3 , NM_005220.2
Accession Version	NM_005220.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 864bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-05
Organism	Homo sapiens(human)
Product	homeobox protein DLX-3
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from CB990401.1, AK075167.1, BC028970.1, BM982262.1 and AA604314.1. This sequence is a reference standard in the RefSeqGene project. On Nov 14, 2003 this sequence version replaced NM_005220.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK313257.1, BC028970.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2142853, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGTGGCT CCTTCGATCG CAAGCTCAGC AGCATCCTCA CCGACATCTC CAGCTCCCTT 
AGCTGCCATG CGGGCTCCAA GGACTCGCCT ACCCTGCCCG AGTCTTCTGT CACTGACCTG 
GGCTACTACA GCGCTCCCCA GCACGATTAC TACTCGGGCC AGCCCTATGG CCAGACGGTG 
AACCCCTACA CCTACCACCA CCAATTCAAT CTCAATGGGC TTGCAGGCAC GGGCGCTTAC 
TCGCCCAAGT CGGAATATAC CTACGGAGCC TCCTACCGGC AATACGGGGC GTATCGGGAG 
CAGCCGCTGC CAGCCCAGGA CCCAGTGTCG GTGAAGGAGG AGCCGGAAGC AGAGGTGCGC 
ATGGTGAATG GGAAGCCCAA GAAGGTCCGA AAGCCGCGTA CGATCTACTC CAGCTACCAG 
CTGGCCGCCC TGCAGCGCCG CTTCCAGAAG GCCCAGTACC TGGCGCTGCC CGAGCGCGCC 
GAGCTGGCCG CGCAGCTGGG CCTCACGCAG ACACAGGTGA AAATCTGGTT CCAGAACCGC 
CGTTCCAAGT TCAAGAAACT CTACAAGAAC GGGGAGGTGC CGCTGGAGCA CAGTCCCAAT 
AACAGTGATT CCATGGCCTG CAACTCACCA CCATCACCCG CCCTCTGGGA CACCTCTTCC 
CACTCCACTC CGGCCCCTGC CCGCAGTCAG CTGCCCCCGC CGCTCCCATA CAGTGCCTCC 
CCCAGCTACC TGGACGACCC CACCAACTCC TGGTATCACG CACAGAACCT GAGTGGACCC 
CACTTACAGC AGCAGCCGCC TCAGCCAGCC ACCCTGCACC ATGCCTCTCC CGGGCCCCCG 
CCCAACCCTG GGGCTGTGTA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_005211.1
CDS	227..1090
Translation	MSGSFDRKLSSILTDISSSLSCHAGSKDSPTLPESSVTDLGYYSAPQHDYYSGQPYGQTVNPYTYHHQFNLNGLAGTGAYSPKSEYTYGASYRQYGAYREQPLPAQDPVSVKEEPEAEVRMVNGKPKKVRKPRTIYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLYKNGEVPLEHSPNNSDSMACNSPPSPALWDTSSHSTPAPARSQLPPPLPYSASPSYLDDPTNSWYHAQNLSGPHLQQQPPQPATLHHASPGPPPNPGAVY

Target ORF information:

RefSeq Version	NM_005220.2
Organism	Homo sapiens(human)
Definition	Homo sapiens distal-less homeobox 3 (DLX3), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_005220.2

ORF Insert Sequence:

ATGAGTGGCT CCTTCGATCG CAAGCTCAGC AGCATCCTCA CCGACATCTC CAGCTCCCTT 
AGCTGCCATG CGGGCTCCAA GGACTCGCCT ACCCTGCCCG AGTCTTCTGT CACTGACCTG 
GGCTACTACA GCGCTCCCCA GCACGATTAC TACTCGGGCC AGCCCTATGG CCAGACGGTG 
AACCCCTACA CCTACCACCA CCAATTCAAT CTCAATGGGC TTGCAGGCAC GGGCGCTTAC 
TCGCCCAAGT CGGAATATAC CTACGGAGCC TCCTACCGGC AATACGGGGC GTATCGGGAG 
CAGCCGCTGC CAGCCCAGGA CCCAGTGTCG GTGAAGGAGG AGCCGGAAGC AGAGGTGCGC 
ATGGTGAATG GGAAGCCCAA GAAGGTCCGA AAGCCGCGTA CGATCTACTC CAGCTACCAG 
CTGGCCGCCC TGCAGCGCCG CTTCCAGAAG GCCCAGTACC TGGCGCTGCC CGAGCGCGCC 
GAGCTGGCCG CGCAGCTGGG CCTCACGCAG ACACAGGTGA AAATCTGGTT CCAGAACCGC 
CGTTCCAAGT TCAAGAAACT CTACAAGAAC GGGGAGGTGC CGCTGGAGCA CAGTCCCAAT 
AACAGTGATT CCATGGCCTG CAACTCACCA CCATCACCCG CCCTCTGGGA CACCTCTTCC 
CACTCCACTC CGGCCCCTGC CCGCAGTCAG CTGCCCCCGC CGCTCCCATA CAGTGCCTCC 
CCCAGCTACC TGGACGACCC CACCAACTCC TGGTATCACG CACAGAACCT GAGTGGACCC 
CACTTACAGC AGCAGCCGCC TCAGCCAGCC ACCCTGCACC ATGCCTCTCC CGGGCCCCCG 
CCCAACCCTG GGGCTGTGTA CTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Lack of Association between BMP2/DLX3 Gene Polymorphisms and Dental Caries in Primary and Permanent Dentitions.
Caries research51(6)590-595(2017 Oct)
Kastovsky J,Borilova Linhartova P,Musilova K,Zackova L,Kukletova M,Kukla L,Izakovicova Holla L

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DLX3 cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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