DLX2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DLX2
Entrez Gene ID	1746
Full Name	distal-less homeobox 2
Synonyms	TES-1,TES1
General protein information	Preferred Names distal-less homeobox 2 Names homeobox protein DLX-2 distal-less homeo box 2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q31.1
Summary	Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. This gene is located in a tail-to-tail configuration with another member of the gene family on the long arm of chromosome 2. [provided by RefSeq, Jul 2008].
Disorder MIM:	126255

mRNA and Protein(s)

mRNA	Protein	Name
NM_004405.3	NP_004396.1	homeobox protein DLX-2
NM_004405.4	NP_004396.1	homeobox protein DLX-2

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	DLX2	XP_515908.3
Rattus norvegicus (Norway rat)	Dlx2	NP_001178675.1
Danio rerio (zebrafish)	dlx2b	NP_571372.1
Homo sapiens (human)	DLX2	NP_004396.1
	DLX2	XP_001086012.1
Mus musculus (house mouse)	Dlx2	NP_034184.1
Danio rerio (zebrafish)	dlx2a	NP_571386.1
Bos taurus (cattle)	DLX2	NP_001179591.1
Canis lupus familiaris (dog)	DLX2	XP_003640223.1
Xenopus tropicalis (tropical clawed frog)	dlx2	NP_001008061.1

Gene Ontology
Bibliography

Related articles in PubMed

Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.
Chang H, Wang Y, Liu H, Nan X, Wong S, Peng S, Gu Y, Zhao H, Feng H
Cell death & disease8(12)3221(2017 Dec)

Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells.
Raja E, Komuro A, Tanabe R, Sakai S, Ino Y, Saito N, Todo T, Morikawa M, Aburatani H, Koinuma D, Iwata C, Miyazono K
Oncogene36(35)4963-4974(2017 Aug)

Polymorphisms in genes involved in enamel development are associated with dental fluorosis.
K?chler EC, Tannure PN, Oliveira DS, Charone S, Nelson-Filho P, Silva RA, Costa MC, Antunes LS, Calasans Maia MD, Antunes LA
Archives of oral biology7666-69(2017 Apr)

Overexpression of DLX2 is associated with poor prognosis and sorafenib resistance in hepatocellular carcinoma.
Liu J, Cui X, Qu L, Hua L, Wu M, Shen Z, Lu C, Ni R
Experimental and molecular pathology101(1)58-65(2016 08)

KI67 and DLX2 predict increased risk of metastasis formation in prostate cancer-a targeted molecular approach.
Green WJ, Ball G, Hulman G, Johnson C, Van Schalwyk G, Ratan HL, Soria D, Garibaldi JM, Parkinson R, Hulman J, Rees R, Powe DG
British journal of cancer115(2)236-42(2016 Jul)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Authors characterized a BMP target gene, Distal-less homeobox 2 (DLX2), and found that DLX2 promoted apoptosis and neural differentiation of glioma-initiating cells.
Title: Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells.

DLX2 is a novel marker of poor prognosis and sorafenib resistance in patients with hepatocellular carcinoma.
Title: Overexpression of DLX2 is associated with poor prognosis and sorafenib resistance in hepatocellular carcinoma.

High Ki67 expression is only present in 6.8% of CaP patients and is predictive of reduced survival and increased risk of metastasis, independent of PSA, Gleason score and D'Amico risk category. DLX2 is a novel marker of increased metastasis risk found in 73% patients and 8.2% showed co-expression with a high Ki67 score
Title: KI67 and DLX2 predict increased risk of metastasis formation in prostate cancer-a targeted molecular approach.

DLX2 expression reduces the protein components of the TTI1/TTI2/TEL2 complex, a key complex required for the proper folding and stabilization of ATM and other members of the PIKK family kinase, leading to reduced ATM-p53 signaling and senescence bypass
Title: A gain-of-function senescence bypass screen identifies the homeobox transcription factor DLX2 as a regulator of ATM-p53 signaling.

DLX2 plays a crucial role in radioresistance, radiation-induced epithelial to mesenchymal transition and cancer stem cell marker expression, and the expression of DLX2 is regulated by Smad2/3 signaling in A549 and MDA-MB-231 cell lines.
Title: Smad2/3-Regulated Expression of DLX2 Is Associated with Radiation-Induced Epithelial-Mesenchymal Transition and Radioresistance of A549 and MDA-MB-231 Human Cancer Cell Lines.

The following DLX2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DLX2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu22403	NM_004405.4 Latest version!	Homo sapiens distal-less homeobox 2 (DLX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
View Old Accession Versions >>
OHu22403	NM_004405.3	Homo sapiens distal-less homeobox 2 (DLX2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$154.50-$216.30 $309.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DLX2 ( NM_004405.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_004396.1 Homo sapiens distal-less homeobox 2 (DLX2), mRNA.

Price & Availability↑

CloneID	OHu22403
Clone ID Related Accession (Same CDS sequence)	NM_004405.3 , NM_004405.4
Accession Version	NM_004405.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-29
Organism	Homo sapiens(human)
Product	homeobox protein DLX-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BE905163.1, AC104801.4 and AA912071.1. This sequence is a reference standard in the RefSeqGene project. On Dec 29, 2005 this sequence version replaced NM_004405.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC032558.1, L07919.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144120, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTGGAG TCTTTGACAG TCTAGTGGCT GATATGCACT CGACCCAGAT CGCCGCCTCC 
AGCACGTACC ACCAGCACCA GCAGCCCCCG AGCGGCGGCG GCGCCGGCCC GGGTGGCAAC 
AGCAGCAGCA GCAGCAGCCT CCACAAGCCC CAGGAGTCGC CCACCCTTCC GGTGTCCACC 
GCCACCGACA GCAGCTACTA CACCAACCAG CAGCACCCGG CGGGCGGCGG CGGCGGCGGG 
GGCTCGCCCT ACGCGCACAT GGGTTCCTAC CAGTACCAAG CCAGCGGCCT CAACAACGTC 
CCTTACTCCG CCAAGAGCAG CTATGACCTG GGCTACACCG CCGCCTACAC CTCCTACGCT 
CCCTATGGAA CCAGTTCGTC CCCAGCCAAC AACGAGCCTG AGAAGGAGGA CCTTGAGCCT 
GAAATTCGGA TAGTGAACGG GAAGCCAAAG AAAGTCCGGA AACCCCGCAC CATCTACTCC 
AGTTTCCAGC TGGCGGCTCT TCAGCGGCGT TTCCAAAAGA CTCAATACTT GGCCTTGCCG 
GAGCGAGCCG AGCTGGCGGC CTCTCTGGGC CTCACCCAGA CTCAGGTCAA AATCTGGTTC 
CAGAACCGCC GGTCCAAGTT CAAGAAGATG TGGAAAAGTG GTGAGATCCC CTCGGAGCAG 
CACCCTGGGG CCAGCGCTTC TCCACCTTGT GCTTCGCCGC CAGTCTCAGC GCCGGCCTCC 
TGGGACTTTG GTGTGCCGCA GCGGATGGCG GGCGGCGGTG GTCCGGGCAG TGGCGGCAGC 
GGCGCCGGCA GCTCGGGCTC CAGCCCGAGC AGCGCGGCCT CGGCTTTTCT GGGCAACTAC 
CCCTGGTACC ACCAGACCTC GGGATCCGCC TCACACCTGC AGGCCACGGC GCCGCTGCTG 
CACCCCACTC AGACCCCGCA GCCGCATCAC CACCACCACC ATCACGGCGG CGGGGGCGCC 
CCGGTGAGCG CGGGGACGAT TTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004396.1
CDS	213..1199
Translation	MTGVFDSLVADMHSTQIAASSTYHQHQQPPSGGGAGPGGNSSSSSSLHKPQESPTLPVSTATDSSYYTNQQHPAGGGGGGGSPYAHMGSYQYQASGLNNVPYSAKSSYDLGYTAAYTSYAPYGTSSSPANNEPEKEDLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGEIPSEQHPGASASPPCASPPVSAPASWDFGVPQRMAGGGGPGSGGSGAGSSGSSPSSAASAFLGNYPWYHQTSGSASHLQATAPLLHPTQTPQPHHHHHHHGGGGAPVSAGTIF

Target ORF information:

RefSeq Version	NM_004405.3
Organism	Homo sapiens(human)
Definition	Homo sapiens distal-less homeobox 2 (DLX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004405.3

ORF Insert Sequence:

ATGACTGGAG TCTTTGACAG TCTAGTGGCT GATATGCACT CGACCCAGAT CGCCGCCTCC 
AGCACGTACC ACCAGCACCA GCAGCCCCCG AGCGGCGGCG GCGCCGGCCC GGGTGGCAAC 
AGCAGCAGCA GCAGCAGCCT CCACAAGCCC CAGGAGTCGC CCACCCTTCC GGTGTCCACC 
GCCACCGACA GCAGCTACTA CACCAACCAG CAGCACCCGG CGGGCGGCGG CGGCGGCGGG 
GGCTCGCCCT ACGCGCACAT GGGTTCCTAC CAGTACCAAG CCAGCGGCCT CAACAACGTC 
CCTTACTCCG CCAAGAGCAG CTATGACCTG GGCTACACCG CCGCCTACAC CTCCTACGCT 
CCCTATGGAA CCAGTTCGTC CCCAGCCAAC AACGAGCCTG AGAAGGAGGA CCTTGAGCCT 
GAAATTCGGA TAGTGAACGG GAAGCCAAAG AAAGTCCGGA AACCCCGCAC CATCTACTCC 
AGTTTCCAGC TGGCGGCTCT TCAGCGGCGT TTCCAAAAGA CTCAATACTT GGCCTTGCCG 
GAGCGAGCCG AGCTGGCGGC CTCTCTGGGC CTCACCCAGA CTCAGGTCAA AATCTGGTTC 
CAGAACCGCC GGTCCAAGTT CAAGAAGATG TGGAAAAGTG GTGAGATCCC CTCGGAGCAG 
CACCCTGGGG CCAGCGCTTC TCCACCTTGT GCTTCGCCGC CAGTCTCAGC GCCGGCCTCC 
TGGGACTTTG GTGTGCCGCA GCGGATGGCG GGCGGCGGTG GTCCGGGCAG TGGCGGCAGC 
GGCGCCGGCA GCTCGGGCTC CAGCCCGAGC AGCGCGGCCT CGGCTTTTCT GGGCAACTAC 
CCCTGGTACC ACCAGACCTC GGGATCCGCC TCACACCTGC AGGCCACGGC GCCGCTGCTG 
CACCCCACTC AGACCCCGCA GCCGCATCAC CACCACCACC ATCACGGCGG CGGGGGCGCC 
CCGGTGAGCG CGGGGACGAT TTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLX2 ( NM_004405.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_004396.1 Homo sapiens distal-less homeobox 2 (DLX2), mRNA.

Price & Availability↑

CloneID	OHu22403
Clone ID Related Accession (Same CDS sequence)	NM_004405.3 , NM_004405.4
Accession Version	NM_004405.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 987bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-09-26
Organism	Homo sapiens(human)
Product	homeobox protein DLX-2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC104801.4, BE905163.1 and AA912071.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_004405.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK291367.1, BC032558.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA2144120, SAMEA2145743 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000234198.9/ ENSP00000234198.4 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACTGGAG TCTTTGACAG TCTAGTGGCT GATATGCACT CGACCCAGAT CGCCGCCTCC 
AGCACGTACC ACCAGCACCA GCAGCCCCCG AGCGGCGGCG GCGCCGGCCC GGGTGGCAAC 
AGCAGCAGCA GCAGCAGCCT CCACAAGCCC CAGGAGTCGC CCACCCTTCC GGTGTCCACC 
GCCACCGACA GCAGCTACTA CACCAACCAG CAGCACCCGG CGGGCGGCGG CGGCGGCGGG 
GGCTCGCCCT ACGCGCACAT GGGTTCCTAC CAGTACCAAG CCAGCGGCCT CAACAACGTC 
CCTTACTCCG CCAAGAGCAG CTATGACCTG GGCTACACCG CCGCCTACAC CTCCTACGCT 
CCCTATGGAA CCAGTTCGTC CCCAGCCAAC AACGAGCCTG AGAAGGAGGA CCTTGAGCCT 
GAAATTCGGA TAGTGAACGG GAAGCCAAAG AAAGTCCGGA AACCCCGCAC CATCTACTCC 
AGTTTCCAGC TGGCGGCTCT TCAGCGGCGT TTCCAAAAGA CTCAATACTT GGCCTTGCCG 
GAGCGAGCCG AGCTGGCGGC CTCTCTGGGC CTCACCCAGA CTCAGGTCAA AATCTGGTTC 
CAGAACCGCC GGTCCAAGTT CAAGAAGATG TGGAAAAGTG GTGAGATCCC CTCGGAGCAG 
CACCCTGGGG CCAGCGCTTC TCCACCTTGT GCTTCGCCGC CAGTCTCAGC GCCGGCCTCC 
TGGGACTTTG GTGTGCCGCA GCGGATGGCG GGCGGCGGTG GTCCGGGCAG TGGCGGCAGC 
GGCGCCGGCA GCTCGGGCTC CAGCCCGAGC AGCGCGGCCT CGGCTTTTCT GGGCAACTAC 
CCCTGGTACC ACCAGACCTC GGGATCCGCC TCACACCTGC AGGCCACGGC GCCGCTGCTG 
CACCCCACTC AGACCCCGCA GCCGCATCAC CACCACCACC ATCACGGCGG CGGGGGCGCC 
CCGGTGAGCG CGGGGACGAT TTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004396.1
CDS	363..1349
Translation	MTGVFDSLVADMHSTQIAASSTYHQHQQPPSGGGAGPGGNSSSSSSLHKPQESPTLPVSTATDSSYYTNQQHPAGGGGGGGSPYAHMGSYQYQASGLNNVPYSAKSSYDLGYTAAYTSYAPYGTSSSPANNEPEKEDLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMWKSGEIPSEQHPGASASPPCASPPVSAPASWDFGVPQRMAGGGGPGSGGSGAGSSGSSPSSAASAFLGNYPWYHQTSGSASHLQATAPLLHPTQTPQPHHHHHHHGGGGAPVSAGTIF

Target ORF information:

RefSeq Version	NM_004405.4
Organism	Homo sapiens(human)
Definition	Homo sapiens distal-less homeobox 2 (DLX2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004405.4

ORF Insert Sequence:

ATGACTGGAG TCTTTGACAG TCTAGTGGCT GATATGCACT CGACCCAGAT CGCCGCCTCC 
AGCACGTACC ACCAGCACCA GCAGCCCCCG AGCGGCGGCG GCGCCGGCCC GGGTGGCAAC 
AGCAGCAGCA GCAGCAGCCT CCACAAGCCC CAGGAGTCGC CCACCCTTCC GGTGTCCACC 
GCCACCGACA GCAGCTACTA CACCAACCAG CAGCACCCGG CGGGCGGCGG CGGCGGCGGG 
GGCTCGCCCT ACGCGCACAT GGGTTCCTAC CAGTACCAAG CCAGCGGCCT CAACAACGTC 
CCTTACTCCG CCAAGAGCAG CTATGACCTG GGCTACACCG CCGCCTACAC CTCCTACGCT 
CCCTATGGAA CCAGTTCGTC CCCAGCCAAC AACGAGCCTG AGAAGGAGGA CCTTGAGCCT 
GAAATTCGGA TAGTGAACGG GAAGCCAAAG AAAGTCCGGA AACCCCGCAC CATCTACTCC 
AGTTTCCAGC TGGCGGCTCT TCAGCGGCGT TTCCAAAAGA CTCAATACTT GGCCTTGCCG 
GAGCGAGCCG AGCTGGCGGC CTCTCTGGGC CTCACCCAGA CTCAGGTCAA AATCTGGTTC 
CAGAACCGCC GGTCCAAGTT CAAGAAGATG TGGAAAAGTG GTGAGATCCC CTCGGAGCAG 
CACCCTGGGG CCAGCGCTTC TCCACCTTGT GCTTCGCCGC CAGTCTCAGC GCCGGCCTCC 
TGGGACTTTG GTGTGCCGCA GCGGATGGCG GGCGGCGGTG GTCCGGGCAG TGGCGGCAGC 
GGCGCCGGCA GCTCGGGCTC CAGCCCGAGC AGCGCGGCCT CGGCTTTTCT GGGCAACTAC 
CCCTGGTACC ACCAGACCTC GGGATCCGCC TCACACCTGC AGGCCACGGC GCCGCTGCTG 
CACCCCACTC AGACCCCGCA GCCGCATCAC CACCACCACC ATCACGGCGG CGGGGGCGCC 
CCGGTGAGCG CGGGGACGAT TTTCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.
Cell death & disease8(12)3221(2017 Dec)
Chang H,Wang Y,Liu H,Nan X,Wong S,Peng S,Gu Y,Zhao H,Feng H

Bone morphogenetic protein signaling mediated by ALK-2 and DLX2 regulates apoptosis in glioma-initiating cells.
Oncogene36(35)4963-4974(2017 Aug)
Raja E,Komuro A,Tanabe R,Sakai S,Ino Y,Saito N,Todo T,Morikawa M,Aburatani H,Koinuma D,Iwata C,Miyazono K

Polymorphisms in genes involved in enamel development are associated with dental fluorosis.
Archives of oral biology7666-69(2017 Apr)
K?chler EC,Tannure PN,Oliveira DS,Charone S,Nelson-Filho P,Silva RA,Costa MC,Antunes LS,Calasans Maia MD,Antunes LA

Overexpression of DLX2 is associated with poor prognosis and sorafenib resistance in hepatocellular carcinoma.
Experimental and molecular pathology101(1)58-65(2016 08)
Liu J,Cui X,Qu L,Hua L,Wu M,Shen Z,Lu C,Ni R

KI67 and DLX2 predict increased risk of metastasis formation in prostate cancer-a targeted molecular approach.
British journal of cancer115(2)236-42(2016 Jul)
Green WJ,Ball G,Hulman G,Johnson C,Van Schalwyk G,Ratan HL,Soria D,Garibaldi JM,Parkinson R,Hulman J,Rees R,Powe DG

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DLX2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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