DLX1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DLX1
Entrez Gene ID	1745
Full Name	distal-less homeobox 1
General protein information	Preferred Names distal-less homeobox 1 Names homeobox protein DLX-1 distal-less homeo box 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2q31.1
Summary	This gene encodes a member of a homeobox transcription factor gene family similiar to the Drosophila distal-less gene. The encoded protein is localized to the nucleus where it may function as a transcriptional regulator of signals from multiple TGF-{beta} superfamily members. The encoded protein may play a role in the control of craniofacial patterning and the differentiation and survival of inhibitory neurons in the forebrain. This gene is located in a tail-to-tail configuration with another member of the family on the long arm of chromosome 2. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
Disorder MIM:	600029

mRNA and Protein(s)

mRNA	Protein	Name
NM_178120.4	NP_835221.2	homeobox protein DLX-1 isoform 1
NM_001038493.1	NP_001033582.1	homeobox protein DLX-1 isoform 2
NM_178120.5	NP_835221.2	homeobox protein DLX-1 isoform 1
NM_001038493.2	NP_001033582.1	homeobox protein DLX-1 isoform 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	DLX1	XP_860852.1
Rattus norvegicus (Norway rat)	Dlx1	NP_001094001.1
Pan troglodytes (chimpanzee)	DLX1	XP_001146865.1
Homo sapiens (human)	DLX1	NP_835221.2
	DLX1	XP_001085798.1
Bos taurus (cattle)	DLX1	NP_001092487.1
Mus musculus (house mouse)	Dlx1	NP_034183.1
Gallus gallus (chicken)	DLX1	NP_001039307.2
Danio rerio (zebrafish)	dlx1a	NP_571380.1
Xenopus tropicalis (tropical clawed frog)	dlx1	NP_001093727.1

Gene Ontology
Bibliography

Related articles in PubMed

DLX1, a binding protein of beta-catenin, promoted the growth and migration of prostate cancer cells.
Liang M, Sun Y, Yang HL, Zhang B, Wen J, Shi BK
Experimental cell research(2018 Jan)

Polymorphisms in genes involved in enamel development are associated with dental fluorosis.
K?chler EC, Tannure PN, Oliveira DS, Charone S, Nelson-Filho P, Silva RA, Costa MC, Antunes LS, Calasans Maia MD, Antunes LA
Archives of oral biology7666-69(2017 Apr)

DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-?/SMAD4 signaling.
Chan DW, Hui WW, Wang JJ, Yung MM, Hui LM, Qin Y, Liang RR, Leung TH, Xu D, Chan KK, Yao KM, Tsang BK, Ngan HY
Oncogene36(10)1404-1416(2017 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

these data strongly suggest that DLX1 has a pivotal role in FOXM1 signaling to promote cancer aggressiveness through intensifying TGF-beta/SMAD4 signaling in high-grade serous ovarian cancer cells.
Title: DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-?/SMAD4 signaling.

DLX1 mRNA levels were shown to be good predictors for the detection of High-grade Prostate Cancer.
Title: Detection of High-grade Prostate Cancer Using a Urinary Molecular Biomarker-Based Risk Score.

TDT results showed an association between DLX1 and cleft lip and palate, in which the A allele was undertransmited (p=0.022).
Title: DLX1 and MMP3 contribute to oral clefts with and without positive family history of cancer.

The regulation of fate switch between cortical and striatal interneurons is dependent on Dlx1 (and Dlx2).
Title: Dlx1&2-dependent expression of Zfhx1b (Sip1, Zeb2) regulates the fate switch between cortical and striatal interneurons.

The study data demonstrate an association between SNP rs7888172 of the DLX1 gene and non-syndromic hypodontia in Chinese Han individuals.
Title: A case-control study of the association between tooth-development gene polymorphisms and non-syndromic hypodontia in the Chinese Han population.

The following DLX1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DLX1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu17358	NM_001038493.2 Latest version!	Homo sapiens distal-less homeobox 1 (DLX1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu17968	NM_178120.5 Latest version!	Homo sapiens distal-less homeobox 1 (DLX1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
View Old Accession Versions >>
OHu17968	NM_178120.4	Homo sapiens distal-less homeobox 1 (DLX1), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$69.30 $99.00
OHu17358	NM_001038493.1	Homo sapiens distal-less homeobox 1 (DLX1), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DLX1 ( NM_001038493.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001033582.1 Homo sapiens distal-less homeobox 1 (DLX1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17358
Clone ID Related Accession (Same CDS sequence)	NM_001038493.1 , NM_001038493.2
Accession Version	NM_001038493.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 390bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-12-22
Organism	Homo sapiens(human)
Product	homeobox protein DLX-1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY257976.1 and BC053351.1. Transcript Variant: This variant (2) lacks an internal exon in the coding region that results in a frameshift and premature stop codon, compared to variant 1. It encodes isoform 2, which has a shorter, distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC053351.1, SRR1803614.225693.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465404 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCATGA CCACCATGCC AGAAAGTCTC AACAGCCCCG TGTCGGGCAA GGCGGTGTTT 
ATGGAGTTTG GGCCGCCCAA CCAGCAAATG TCTCCTTCTC CCATGTCCCA CGGGCACTAC 
TCCATGCACT GTTTACACTC GGCGGGCCAT TCGCAGCCCG ACGGCGCCTA CAGCTCAGCC 
TCGTCCTTCT CCCGACCGCT GGGCTACCCC TACGTCAACT CGGTCAGCAG CCACGCATCC 
AGCCCCTACA TCAGTTCGGT GCAGTCCTAC CCGGGCAGCG CCAGCCTCGC CCAGAGCCGC 
CTGGAGGACC CAGGTCAAGA TCTGGTTCCA AAACAAGCGA TCCAAGTTCA AGAAGCTGAT 
GAAGCAGGGT GGGGCGGCTC TGGAGGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001033582.1
CDS	199..588
Translation	MTMTTMPESLNSPVSGKAVFMEFGPPNQQMSPSPMSHGHYSMHCLHSAGHSQPDGAYSSASSFSRPLGYPYVNSVSSHASSPYISSVQSYPGSASLAQSRLEDPGQDLVPKQAIQVQEADEAGWGGSGG

Target ORF information:

RefSeq Version	NM_001038493.1
Organism	Homo sapiens(human)
Definition	Homo sapiens distal-less homeobox 1 (DLX1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001038493.1

ORF Insert Sequence:

ATGACCATGA CCACCATGCC AGAAAGTCTC AACAGCCCCG TGTCGGGCAA GGCGGTGTTT 
ATGGAGTTTG GGCCGCCCAA CCAGCAAATG TCTCCTTCTC CCATGTCCCA CGGGCACTAC 
TCCATGCACT GTTTACACTC GGCGGGCCAT TCGCAGCCCG ACGGCGCCTA CAGCTCAGCC 
TCGTCCTTCT CCCGACCGCT GGGCTACCCC TACGTCAACT CGGTCAGCAG CCACGCATCC 
AGCCCCTACA TCAGTTCGGT GCAGTCCTAC CCGGGCAGCG CCAGCCTCGC CCAGAGCCGC 
CTGGAGGACC CAGGTCAAGA TCTGGTTCCA AAACAAGCGA TCCAAGTTCA AGAAGCTGAT 
GAAGCAGGGT GGGGCGGCTC TGGAGGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLX1 ( NM_001038493.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001033582.1 Homo sapiens distal-less homeobox 1 (DLX1), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu17358
Clone ID Related Accession (Same CDS sequence)	NM_001038493.1 , NM_001038493.2
Accession Version	NM_001038493.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 390bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-20
Organism	Homo sapiens(human)
Product	homeobox protein DLX-1 isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY257976.1 and BC053351.1. On May 31, 2019 this sequence version replaced NM_001038493.1. Transcript Variant: This variant (2) lacks an internal exon in the coding region that results in a frameshift and premature stop codon, compared to variant 1. It encodes isoform 2, which has a shorter, distinct C-terminus, compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC053351.1, SRR1803614.225693.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN03465404 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCATGA CCACCATGCC AGAAAGTCTC AACAGCCCCG TGTCGGGCAA GGCGGTGTTT 
ATGGAGTTTG GGCCGCCCAA CCAGCAAATG TCTCCTTCTC CCATGTCCCA CGGGCACTAC 
TCCATGCACT GTTTACACTC GGCGGGCCAT TCGCAGCCCG ACGGCGCCTA CAGCTCAGCC 
TCGTCCTTCT CCCGACCGCT GGGCTACCCC TACGTCAACT CGGTCAGCAG CCACGCATCC 
AGCCCCTACA TCAGTTCGGT GCAGTCCTAC CCGGGCAGCG CCAGCCTCGC CCAGAGCCGC 
CTGGAGGACC CAGGTCAAGA TCTGGTTCCA AAACAAGCGA TCCAAGTTCA AGAAGCTGAT 
GAAGCAGGGT GGGGCGGCTC TGGAGGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001033582.1
CDS	172..561
Translation	MTMTTMPESLNSPVSGKAVFMEFGPPNQQMSPSPMSHGHYSMHCLHSAGHSQPDGAYSSASSFSRPLGYPYVNSVSSHASSPYISSVQSYPGSASLAQSRLEDPGQDLVPKQAIQVQEADEAGWGGSGG

Target ORF information:

RefSeq Version	NM_001038493.2
Organism	Homo sapiens(human)
Definition	Homo sapiens distal-less homeobox 1 (DLX1), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001038493.2

ORF Insert Sequence:

ATGACCATGA CCACCATGCC AGAAAGTCTC AACAGCCCCG TGTCGGGCAA GGCGGTGTTT 
ATGGAGTTTG GGCCGCCCAA CCAGCAAATG TCTCCTTCTC CCATGTCCCA CGGGCACTAC 
TCCATGCACT GTTTACACTC GGCGGGCCAT TCGCAGCCCG ACGGCGCCTA CAGCTCAGCC 
TCGTCCTTCT CCCGACCGCT GGGCTACCCC TACGTCAACT CGGTCAGCAG CCACGCATCC 
AGCCCCTACA TCAGTTCGGT GCAGTCCTAC CCGGGCAGCG CCAGCCTCGC CCAGAGCCGC 
CTGGAGGACC CAGGTCAAGA TCTGGTTCCA AAACAAGCGA TCCAAGTTCA AGAAGCTGAT 
GAAGCAGGGT GGGGCGGCTC TGGAGGGTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLX1 ( NM_178120.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_835221.2 Homo sapiens distal-less homeobox 1 (DLX1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17968
Clone ID Related Accession (Same CDS sequence)	NM_178120.4 , NM_178120.5
Accession Version	NM_178120.4	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-09-09
Organism	Homo sapiens(human)
Product	homeobox protein DLX-1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY257976.1, BC036189.1 and BC053351.1. This sequence is a reference standard in the RefSeqGene project. On Dec 29, 2005 this sequence version replaced NM_178120.3. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY257976.1, BC036189.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACCATGA CCACCATGCC AGAAAGTCTC AACAGCCCCG TGTCGGGCAA GGCGGTGTTT 
ATGGAGTTTG GGCCGCCCAA CCAGCAAATG TCTCCTTCTC CCATGTCCCA CGGGCACTAC 
TCCATGCACT GTTTACACTC GGCGGGCCAT TCGCAGCCCG ACGGCGCCTA CAGCTCAGCC 
TCGTCCTTCT CCCGACCGCT GGGCTACCCC TACGTCAACT CGGTCAGCAG CCACGCATCC 
AGCCCCTACA TCAGTTCGGT GCAGTCCTAC CCGGGCAGCG CCAGCCTCGC CCAGAGCCGC 
CTGGAGGACC CAGGGGCGGA CTCGGAGAAG AGCACGGTGG TGGAAGGCGG TGAAGTGCGC 
TTCAATGGCA AGGGAAAAAA GATCCGTAAA CCCAGGACGA TTTATTCCAG TTTGCAGTTG 
CAGGCTTTGA ACCGGAGGTT CCAGCAAACT CAGTACCTAG CTCTGCCGGA GAGGGCGGAG 
CTCGCGGCCT CTTTGGGACT CACACAGACT CAGGTCAAGA TCTGGTTCCA AAACAAGCGA 
TCCAAGTTCA AGAAGCTGAT GAAGCAGGGT GGGGCGGCTC TGGAGGGTAG TGCGTTGGCC 
AACGGTCGGG CCCTGTCTGC TGGCTCCCCA CCCGTGCCGC CCGGCTGGAA CCCTAACTCT 
TCATCCGGGA AGGGCTCAGG AGGAAACGCG GGCTCCTATA TCCCCAGCTA CACATCGTGG 
TACCCTTCAG CGCACCAAGA AGCTATGCAG CAACCCCAAC TTATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_835221.2
CDS	199..966
Translation	MTMTTMPESLNSPVSGKAVFMEFGPPNQQMSPSPMSHGHYSMHCLHSAGHSQPDGAYSSASSFSRPLGYPYVNSVSSHASSPYISSVQSYPGSASLAQSRLEDPGADSEKSTVVEGGEVRFNGKGKKIRKPRTIYSSLQLQALNRRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLMKQGGAALEGSALANGRALSAGSPPVPPGWNPNSSSGKGSGGNAGSYIPSYTSWYPSAHQEAMQQPQLM

Target ORF information:

RefSeq Version	NM_178120.4
Organism	Homo sapiens(human)
Definition	Homo sapiens distal-less homeobox 1 (DLX1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178120.4

ORF Insert Sequence:

ATGACCATGA CCACCATGCC AGAAAGTCTC AACAGCCCCG TGTCGGGCAA GGCGGTGTTT 
ATGGAGTTTG GGCCGCCCAA CCAGCAAATG TCTCCTTCTC CCATGTCCCA CGGGCACTAC 
TCCATGCACT GTTTACACTC GGCGGGCCAT TCGCAGCCCG ACGGCGCCTA CAGCTCAGCC 
TCGTCCTTCT CCCGACCGCT GGGCTACCCC TACGTCAACT CGGTCAGCAG CCACGCATCC 
AGCCCCTACA TCAGTTCGGT GCAGTCCTAC CCGGGCAGCG CCAGCCTCGC CCAGAGCCGC 
CTGGAGGACC CAGGGGCGGA CTCGGAGAAG AGCACGGTGG TGGAAGGCGG TGAAGTGCGC 
TTCAATGGCA AGGGAAAAAA GATCCGTAAA CCCAGGACGA TTTATTCCAG TTTGCAGTTG 
CAGGCTTTGA ACCGGAGGTT CCAGCAAACT CAGTACCTAG CTCTGCCGGA GAGGGCGGAG 
CTCGCGGCCT CTTTGGGACT CACACAGACT CAGGTCAAGA TCTGGTTCCA AAACAAGCGA 
TCCAAGTTCA AGAAGCTGAT GAAGCAGGGT GGGGCGGCTC TGGAGGGTAG TGCGTTGGCC 
AACGGTCGGG CCCTGTCTGC TGGCTCCCCA CCCGTGCCGC CCGGCTGGAA CCCTAACTCT 
TCATCCGGGA AGGGCTCAGG AGGAAACGCG GGCTCCTATA TCCCCAGCTA CACATCGTGG 
TACCCTTCAG CGCACCAAGA AGCTATGCAG CAACCCCAAC TTATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DLX1 ( NM_178120.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_835221.2 Homo sapiens distal-less homeobox 1 (DLX1), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu17968
Clone ID Related Accession (Same CDS sequence)	NM_178120.4 , NM_178120.5
Accession Version	NM_178120.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 768bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	homeobox protein DLX-1 isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY257976.1, BC036189.1 and BC053351.1. This sequence is a reference standard in the RefSeqGene project. On Nov 22, 2018 this sequence version replaced NM_178120.4. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660807.59592.1, BC036189.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2144120 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000361725.5/ ENSP00000354478.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGACCATGA CCACCATGCC AGAAAGTCTC AACAGCCCCG TGTCGGGCAA GGCGGTGTTT 
ATGGAGTTTG GGCCGCCCAA CCAGCAAATG TCTCCTTCTC CCATGTCCCA CGGGCACTAC 
TCCATGCACT GTTTACACTC GGCGGGCCAT TCGCAGCCCG ACGGCGCCTA CAGCTCAGCC 
TCGTCCTTCT CCCGACCGCT GGGCTACCCC TACGTCAACT CGGTCAGCAG CCACGCATCC 
AGCCCCTACA TCAGTTCGGT GCAGTCCTAC CCGGGCAGCG CCAGCCTCGC CCAGAGCCGC 
CTGGAGGACC CAGGGGCGGA CTCGGAGAAG AGCACGGTGG TGGAAGGCGG TGAAGTGCGC 
TTCAATGGCA AGGGAAAAAA GATCCGTAAA CCCAGGACGA TTTATTCCAG TTTGCAGTTG 
CAGGCTTTGA ACCGGAGGTT CCAGCAAACT CAGTACCTAG CTCTGCCGGA GAGGGCGGAG 
CTCGCGGCCT CTTTGGGACT CACACAGACT CAGGTCAAGA TCTGGTTCCA AAACAAGCGA 
TCCAAGTTCA AGAAGCTGAT GAAGCAGGGT GGGGCGGCTC TGGAGGGTAG TGCGTTGGCC 
AACGGTCGGG CCCTGTCTGC TGGCTCCCCA CCCGTGCCGC CCGGCTGGAA CCCTAACTCT 
TCATCCGGGA AGGGCTCAGG AGGAAACGCG GGCTCCTATA TCCCCAGCTA CACATCGTGG 
TACCCTTCAG CGCACCAAGA AGCTATGCAG CAACCCCAAC TTATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_835221.2
CDS	172..939
Translation	MTMTTMPESLNSPVSGKAVFMEFGPPNQQMSPSPMSHGHYSMHCLHSAGHSQPDGAYSSASSFSRPLGYPYVNSVSSHASSPYISSVQSYPGSASLAQSRLEDPGADSEKSTVVEGGEVRFNGKGKKIRKPRTIYSSLQLQALNRRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSKFKKLMKQGGAALEGSALANGRALSAGSPPVPPGWNPNSSSGKGSGGNAGSYIPSYTSWYPSAHQEAMQQPQLM

Target ORF information:

RefSeq Version	NM_178120.5
Organism	Homo sapiens(human)
Definition	Homo sapiens distal-less homeobox 1 (DLX1), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_178120.5

ORF Insert Sequence:

ATGACCATGA CCACCATGCC AGAAAGTCTC AACAGCCCCG TGTCGGGCAA GGCGGTGTTT 
ATGGAGTTTG GGCCGCCCAA CCAGCAAATG TCTCCTTCTC CCATGTCCCA CGGGCACTAC 
TCCATGCACT GTTTACACTC GGCGGGCCAT TCGCAGCCCG ACGGCGCCTA CAGCTCAGCC 
TCGTCCTTCT CCCGACCGCT GGGCTACCCC TACGTCAACT CGGTCAGCAG CCACGCATCC 
AGCCCCTACA TCAGTTCGGT GCAGTCCTAC CCGGGCAGCG CCAGCCTCGC CCAGAGCCGC 
CTGGAGGACC CAGGGGCGGA CTCGGAGAAG AGCACGGTGG TGGAAGGCGG TGAAGTGCGC 
TTCAATGGCA AGGGAAAAAA GATCCGTAAA CCCAGGACGA TTTATTCCAG TTTGCAGTTG 
CAGGCTTTGA ACCGGAGGTT CCAGCAAACT CAGTACCTAG CTCTGCCGGA GAGGGCGGAG 
CTCGCGGCCT CTTTGGGACT CACACAGACT CAGGTCAAGA TCTGGTTCCA AAACAAGCGA 
TCCAAGTTCA AGAAGCTGAT GAAGCAGGGT GGGGCGGCTC TGGAGGGTAG TGCGTTGGCC 
AACGGTCGGG CCCTGTCTGC TGGCTCCCCA CCCGTGCCGC CCGGCTGGAA CCCTAACTCT 
TCATCCGGGA AGGGCTCAGG AGGAAACGCG GGCTCCTATA TCCCCAGCTA CACATCGTGG 
TACCCTTCAG CGCACCAAGA AGCTATGCAG CAACCCCAAC TTATGTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

DLX1, a binding protein of beta-catenin, promoted the growth and migration of prostate cancer cells.
Experimental cell research(2018 Jan)
Liang M,Sun Y,Yang HL,Zhang B,Wen J,Shi BK

Polymorphisms in genes involved in enamel development are associated with dental fluorosis.
Archives of oral biology7666-69(2017 Apr)
K?chler EC,Tannure PN,Oliveira DS,Charone S,Nelson-Filho P,Silva RA,Costa MC,Antunes LS,Calasans Maia MD,Antunes LA

DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-?/SMAD4 signaling.
Oncogene36(10)1404-1416(2017 Mar)
Chan DW,Hui WW,Wang JJ,Yung MM,Hui LM,Qin Y,Liang RR,Leung TH,Xu D,Chan KK,Yao KM,Tsang BK,Ngan HY

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DLX1 cDNA ORF clone, Homo sapiens(human)

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gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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