PSORS1C1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	PSORS1C1
Entrez Gene ID	170679
Full Name	psoriasis susceptibility 1 candidate 1
Synonyms	C6orf16,SEEK1
General protein information	Preferred Names psoriasis susceptibility 1 candidate 1 Names psoriasis susceptibility 1 candidate gene 1 protein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 6 Map Location: 6p21.33
Summary	This gene is one of several genes thought to confer susceptibility to psoriasis and systemic sclerosis, located on chromosome 6 near the major histocompatibility complex (MHC) class I region. [provided by RefSeq, Sep 2011].
Disorder MIM:	613525

mRNA and Protein(s)

mRNA	Protein	Name
NM_014068.2	NP_054787.2	psoriasis susceptibility 1 candidate gene 1 protein
NM_014068.3	NP_054787.2	psoriasis susceptibility 1 candidate gene 1 protein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	PSORS1C1	NP_001121612.1
Homo sapiens (human)	PSORS1C1	NP_054787.2

Gene Ontology
Bibliography

Related articles in PubMed

The minor allele HCP5 rs3099844 A, PSORS1C1 rs3131003 G are associated with allopurinol-induced severe cutaneous adverse reactions in Han Chinese: a multicentre retrospective case-control clinical study.
Cheng L, Sun B, Xiong Y, Hu L, Gao L, Lv Q, Zhou M, Li J, Chen X, Zhang W, Zhou HH
The British journal of dermatology(2017 Nov)

Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 Genes Are Associated with the Response to TNF Inhibitors in Patients with Rheumatoid Arthritis.
Conigliaro P, Ciccacci C, Politi C, Triggianese P, Rufini S, Kroegler B, Perricone C, Latini A, Novelli G, Borgiani P, Perricone R
PloS one12(1)e0169956(2017)

Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis.
Ciccacci C, Conigliaro P, Perricone C, Rufini S, Triggianese P, Politi C, Novelli G, Perricone R, Borgiani P
Clinical and experimental immunology186(2)157-163(2016 Nov)

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
He M, Xu M, Zhang B, Liang J, Chen P, Lee JY, Johnson TA, Li H, Yang X, Dai J, Liang L, Gui L, Qi Q, Huang J, Li Y, Adair LS, Aung T, Cai Q, Cheng CY, Cho MC, Cho YS, Chu M, Cui B, Gao YT, Go MJ, Gu D, Gu W, Guo H, Hao Y, Hong J, Hu Z, Hu Y, Huang J, Hwang JY, Ikram MK, Jin G, Kang DH, Khor CC, Kim BJ, Kim HT, Kubo M, Lee J, Lee J, Lee NR, Li R, Li J, Liu J, Longe J, Lu W, Lu X, Miao X, Okada Y, Ong RT, Qiu G, Seielstad M, Sim X, Song H, Takeuchi F, Tanaka T, Taylor PR, Wang L, Wang W, Wang Y, Wu C, Wu Y, Xiang YB, Yamamoto K, Yang H, Liao M, Yokota M, Young T, Zhang X, Kato N, Wang QK, Zheng W, Hu FB, Lin D, Shen H, Teo YY, Mo Z, Wong TY, Lin X, Mohlke KL, Ning G, Tsunoda T, Han BG, Shu XO, Tai ES, Wu T, Qi L
Human molecular genetics24(6)1791-800(2015 Mar)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Patients carrying PSORS1C1 variant allele rs2233945 did not reach low disease activity at 6 months in both the whole RA group and Etanercept treated patients.
Title: Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 Genes Are Associated with the Response to TNF Inhibitors in Patients with Rheumatoid Arthritis.

ACPA were associated significantly with rs7574865 in STAT-4. The SNP rs2233945 in the PSORS1C1 gene was protective regarding the presence of bone erosions, while rs2542151 in PTPN2 gene was associated with joint damage.
Title: Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis.

The association has been found between PSORS1C1 SNPs and asthma in Hispanic Americans.
Title: Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study.

PSORS1C1/CDSN gene may play a pathogenic role in ankylosing spondylitis
Title: PSORS1C1/CDSN is associated with ankylosing spondylitis.

this study demonstrates that SNPs in the PSORS1C1-encoding gene have a strong association with RA.
Title: PSORS1C1 may be involved in rheumatoid arthritis.

The following PSORS1C1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the PSORS1C1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19549	NM_014068.3 Latest version!	Homo sapiens psoriasis susceptibility 1 candidate 1 (PSORS1C1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu19549	NM_014068.2	Homo sapiens psoriasis susceptibility 1 candidate 1 (PSORS1C1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

PSORS1C1 ( NM_014068.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_054787.2 Homo sapiens psoriasis susceptibility 1 candidate 1 (PSORS1C1), mRNA.

Price & Availability↑

CloneID	OHu19549
Clone ID Related Accession (Same CDS sequence)	NM_014068.2 , NM_014068.3
Accession Version	NM_014068.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-10-08
Organism	Homo sapiens(human)
Product	psoriasis susceptibility 1 candidate gene 1 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AF484418.1, DB454051.1, BI825917.1 and AI243345.1. This sequence is a reference standard in the RefSeqGene project. On May 14, 2010 this sequence version replaced NM_014068.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB031479.1, AF484418.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2144333, SAMEA2156266 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGACTTGCA CAGACCAAAA AAGTCACTCT CAAAGAGCTC TCGGCACACA GACCCCAGCT 
TTACAAGGAC CCCAGCTCCT TAACACAGAT CCCAGCTCCG AGGAAACTCG TCCCCCCCAC 
GTTAATCCTG ACCGACTTTG CCACATGGAG CCAGCAAACC ATTTCTGGCA TGCAGGGGAC 
CTCCAAGCAA TGATATCCAA GGAATTCCAT CTGGCAGCCA CCCAGGATGA CTGCAGAAAA 
GGAAGGACAC AGGAGGATAT CCTGGTTCCC TCTTCCCACC CAGAGCTGTT TGCATCAGTC 
CTGCCAATGG CTCCGGAAGA AGCTGCCAGG CTCCAGCAAC CTCAGCCCCT TCCTCCTCCC 
TCAGGAATCC ACCTATCCGC CTCTAGGACC TTGGCTCCAA CTCTATTGTA CTCGTCTCCT 
CCCTCCCATT CTCCTTTTGG TCTCAGCTCC TTGATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054787.2
CDS	290..748
Translation	MTCTDQKSHSQRALGTQTPALQGPQLLNTDPSSEETRPPHVNPDRLCHMEPANHFWHAGDLQAMISKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPPSGIHLSASRTLAPTLLYSSPPSHSPFGLSSLI

Target ORF information:

RefSeq Version	NM_014068.2
Organism	Homo sapiens(human)
Definition	Homo sapiens psoriasis susceptibility 1 candidate 1 (PSORS1C1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014068.2

ORF Insert Sequence:

ATGACTTGCA CAGACCAAAA AAGTCACTCT CAAAGAGCTC TCGGCACACA GACCCCAGCT 
TTACAAGGAC CCCAGCTCCT TAACACAGAT CCCAGCTCCG AGGAAACTCG TCCCCCCCAC 
GTTAATCCTG ACCGACTTTG CCACATGGAG CCAGCAAACC ATTTCTGGCA TGCAGGGGAC 
CTCCAAGCAA TGATATCCAA GGAATTCCAT CTGGCAGCCA CCCAGGATGA CTGCAGAAAA 
GGAAGGACAC AGGAGGATAT CCTGGTTCCC TCTTCCCACC CAGAGCTGTT TGCATCAGTC 
CTGCCAATGG CTCCGGAAGA AGCTGCCAGG CTCCAGCAAC CTCAGCCCCT TCCTCCTCCC 
TCAGGAATCC ACCTATCCGC CTCTAGGACC TTGGCTCCAA CTCTATTGTA CTCGTCTCCT 
CCCTCCCATT CTCCTTTTGG TCTCAGCTCC TTGATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PSORS1C1 ( NM_014068.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_054787.2 Homo sapiens psoriasis susceptibility 1 candidate 1 (PSORS1C1), mRNA.

Price & Availability↑

CloneID	OHu19549
Clone ID Related Accession (Same CDS sequence)	NM_014068.2 , NM_014068.3
Accession Version	NM_014068.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 459bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	psoriasis susceptibility 1 candidate gene 1 protein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL662844.12. On May 17, 2019 this sequence version replaced NM_014068.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AB031479.1, AF484418.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA2144333, SAMEA2156266 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000259881.10/ ENSP00000259881.9 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGACTTGCA CAGACCAAAA AAGTCACTCT CAAAGAGCTC TCGGCACACA GACCCCAGCT 
TTACAAGGAC CCCAGCTCCT TAACACAGAT CCCAGCTCCG AGGAAACTCG TCCCCCCCAC 
GTTAATCCTG ACCGACTTTG CCACATGGAG CCAGCAAACC ATTTCTGGCA TGCAGGGGAC 
CTCCAAGCAA TGATATCCAA GGAATTCCAT CTGGCAGCCA CCCAGGATGA CTGCAGAAAA 
GGAAGGACAC AGGAGGATAT CCTGGTTCCC TCTTCCCACC CAGAGCTGTT TGCATCAGTC 
CTGCCAATGG CTCCGGAAGA AGCTGCCAGG CTCCAGCAAC CTCAGCCCCT TCCTCCTCCC 
TCAGGAATCC ACCTATCCGC CTCTAGGACC TTGGCTCCAA CTCTATTGTA CTCGTCTCCT 
CCCTCCCATT CTCCTTTTGG TCTCAGCTCC TTGATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_054787.2
CDS	321..779
Translation	MTCTDQKSHSQRALGTQTPALQGPQLLNTDPSSEETRPPHVNPDRLCHMEPANHFWHAGDLQAMISKEFHLAATQDDCRKGRTQEDILVPSSHPELFASVLPMAPEEAARLQQPQPLPPPSGIHLSASRTLAPTLLYSSPPSHSPFGLSSLI

Target ORF information:

RefSeq Version	NM_014068.3
Organism	Homo sapiens(human)
Definition	Homo sapiens psoriasis susceptibility 1 candidate 1 (PSORS1C1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_014068.3

ORF Insert Sequence:

ATGACTTGCA CAGACCAAAA AAGTCACTCT CAAAGAGCTC TCGGCACACA GACCCCAGCT 
TTACAAGGAC CCCAGCTCCT TAACACAGAT CCCAGCTCCG AGGAAACTCG TCCCCCCCAC 
GTTAATCCTG ACCGACTTTG CCACATGGAG CCAGCAAACC ATTTCTGGCA TGCAGGGGAC 
CTCCAAGCAA TGATATCCAA GGAATTCCAT CTGGCAGCCA CCCAGGATGA CTGCAGAAAA 
GGAAGGACAC AGGAGGATAT CCTGGTTCCC TCTTCCCACC CAGAGCTGTT TGCATCAGTC 
CTGCCAATGG CTCCGGAAGA AGCTGCCAGG CTCCAGCAAC CTCAGCCCCT TCCTCCTCCC 
TCAGGAATCC ACCTATCCGC CTCTAGGACC TTGGCTCCAA CTCTATTGTA CTCGTCTCCT 
CCCTCCCATT CTCCTTTTGG TCTCAGCTCC TTGATCTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The minor allele HCP5 rs3099844 A, PSORS1C1 rs3131003 G are associated with allopurinol-induced severe cutaneous adverse reactions in Han Chinese: a multicentre retrospective case-control clinical study.
The British journal of dermatology(2017 Nov)
Cheng L,Sun B,Xiong Y,Hu L,Gao L,Lv Q,Zhou M,Li J,Chen X,Zhang W,Zhou HH

Polymorphisms in STAT4, PTPN2, PSORS1C1 and TRAF3IP2 Genes Are Associated with the Response to TNF Inhibitors in Patients with Rheumatoid Arthritis.
PloS one12(1)e0169956(2017)
Conigliaro P,Ciccacci C,Politi C,Triggianese P,Rufini S,Kroegler B,Perricone C,Latini A,Novelli G,Borgiani P,Perricone R

Polymorphisms in STAT-4, IL-10, PSORS1C1, PTPN2 and MIR146A genes are associated differently with prognostic factors in Italian patients affected by rheumatoid arthritis.
Clinical and experimental immunology186(2)157-163(2016 Nov)
Ciccacci C,Conigliaro P,Perricone C,Rufini S,Triggianese P,Politi C,Novelli G,Perricone R,Borgiani P

Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
Human molecular genetics24(6)1791-800(2015 Mar)
He M,Xu M,Zhang B,Liang J,Chen P,Lee JY,Johnson TA,Li H,Yang X,Dai J,Liang L,Gui L,Qi Q,Huang J,Li Y,Adair LS,Aung T,Cai Q,Cheng CY,Cho MC,Cho YS,Chu M,Cui B,Gao YT,Go MJ,Gu D,Gu W,Guo H,Hao Y,Hong J,Hu Z,Hu Y,Huang J,Hwang JY,Ikram MK,Jin G,Kang DH,Khor CC,Kim BJ,Kim HT,Kubo M,Lee J,Lee J,Lee NR,Li R,Li J,Liu J,Longe J,Lu W,Lu X,Miao X,Okada Y,Ong RT,Qiu G,Seielstad M,Sim X,Song H,Takeuchi F,Tanaka T,Taylor PR,Wang L,Wang W,Wang Y,Wu C,Wu Y,Xiang YB,Yamamoto K,Yang H,Liao M,Yokota M,Young T,Zhang X,Kato N,Wang QK,Zheng W,Hu FB,Lin D,Shen H,Teo YY,Mo Z,Wong TY,Lin X,Mohlke KL,Ning G,Tsunoda T,Han BG,Shu XO,Tai ES,Wu T,Qi L

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PSORS1C1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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