GIMAP1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	GIMAP1
Entrez Gene ID	170575
Full Name	GTPase, IMAP family member 1
Synonyms	HIMAP1,IAN2,IMAP1,IMAP38
General protein information	Preferred Names GTPase, IMAP family member 1 Names GTPase IMAP family member 1 immune-associated nucleotide-binding protein 2 immunity associated protein 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q36.1
Summary	This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. This gene is thought to be involved in the differentiation of T helper (Th) cells of the Th1 lineage, and the related mouse gene has been shown to be critical for the development of mature B and T lymphocytes. Read-through transcription exists between this gene and the downstream GIMAP5 (GTPase, IMAP family member 5) gene. [provided by RefSeq, Dec 2010].
Disorder MIM:	608084

mRNA and Protein(s)

mRNA	Protein	Name
NM_130759.3	NP_570115.1	GTPase IMAP family member 1
NM_130759.4	NP_570115.1	GTPase IMAP family member 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	GIMAP1	NP_570115.1
Mus musculus (house mouse)	Gimap1	NP_787056.1
	LOC100424486	XP_002803576.1
Rattus norvegicus (Norway rat)	Gimap1	NP_001030021.1
Bos taurus (cattle)	LOC512867	NP_001077146.1
Bos taurus (cattle)	GIMAP1	XP_005206003.1
Canis lupus familiaris (dog)	GIMAP1	XP_003432106.1

Gene Ontology
Bibliography

Related articles in PubMed

Genome-wide association study identified copy number variants important for appendicular lean mass.
Ran S, Liu YJ, Zhang L, Pei Y, Yang TL, Hai R, Han YY, Lin Y, Tian Q, Deng HW
PloS one9(3)e89776(2014)

Putative GTPase GIMAP1 is critical for the development of mature B and T lymphocytes.
Saunders A, Webb LM, Janas ML, Hutchings A, Pascall J, Carter C, Pugh N, Morgan G, Turner M, Butcher GW
Blood115(16)3249-57(2010 Apr)

Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation.
Fil?n JJ, Fil?n S, Moulder R, Tuomela S, Ahlfors H, West A, Kouvonen P, Kantola S, Bj?rkman M, Katajamaa M, Rasool O, Nyman TA, Lahesmaa R
Molecular & cellular proteomics : MCP8(1)32-44(2009 Jan)

Comparative analysis of the human gimap gene cluster encoding a novel GTPase family.
Kr?cken J, Schroetel RM, M?ller IU, Sa?dani N, Marinovski P, Benten WP, Stamm O, Wunderlich F
Gene341291-304(2004 Oct)

Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36.
Stamm O, Kr?cken J, Schmitt-Wrede HP, Benten WP, Wunderlich F
Gene282(1-2)159-67(2002 Jan)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

GIMAP1 and SERHL variants may be important for appendicular lean mass
Title: Genome-wide association study identified copy number variants important for appendicular lean mass.

Shows a critical role for the related mouse gene in mature lymphocyte development and survival.
Title: Putative GTPase GIMAP1 is critical for the development of mature B and T lymphocytes.

GIMAP1 and GIMAP4 genes are up-regulated by IL-12 and other Th1 differentiation-inducing cytokines in cells induced to differentiate toward Th1 lineage and down-regulated by IL-4 in cells induced to Th2.
Title: Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation.

The himap1 gene belongs to a gene family clustered on chromosome 7q32-36 within a region highly syntenic to the mouse imap38 locus on chromosome 6B.
Title: Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36.

The following GIMAP1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the GIMAP1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu15491	NM_130759.4 Latest version!	Homo sapiens GTPase, IMAP family member 1 (GIMAP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
View Old Accession Versions >>
OHu15491	NM_130759.3	Homo sapiens GTPase, IMAP family member 1 (GIMAP1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

GIMAP1 ( NM_130759.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_570115.1 Homo sapiens GTPase, IMAP family member 1 (GIMAP1), mRNA.

Price & Availability↑

CloneID	OHu15491
Clone ID Related Accession (Same CDS sequence)	NM_130759.3 , NM_130759.4
Accession Version	NM_130759.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-01
Organism	Homo sapiens(human)
Product	GTPase IMAP family member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA817535.1, BC040736.1, AC006479.2 and AW029312.1. On Dec 9, 2010 this sequence version replaced NM_130759.2. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: DA817535.1, AK091818.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGGAGGAA GGAAGATGGC GACAGATGAA GAAAATGTCT ATGGTTTAGA AGAGAACGCT 
CAGTCCCGGC AGGAGTCCAC GCGGAGGCTC ATCCTTGTTG GGAGAACAGG GGCCGGGAAG 
AGCGCCACTG GGAACAGCAT CCTGGGCCAG AGACGGTTCT TCTCCAGGCT GGGGGCCACG 
TCTGTGACCA GGGCCTGCAC CACGGGCAGC CGCAGGTGGG ACAAGTGCCA CGTGGAAGTC 
GTGGACACTC CGGACATTTT CAGCTCCCAA GTGTCCAAGA CAGATCCTGG CTGTGAGGAG 
AGAGGTCACT GCTACCTGCT CTCGGCCCCC GGACCCCACG CGCTGCTCCT GGTGACCCAG 
TTGGGTCGGT TCACCGCCCA GGACCAGCAG GCGGTGAGGC AGGTGAGGGA CATGTTCGGG 
GAGGACGTCC TAAAATGGAT GGTCATCGTC TTCACCAGGA AGGAGGACCT GGCCGGGGGC 
TCCCTGCACG ATTACGTGAG CAACACAGAG AACCGGGCCT TGCGCGAGCT GGTGGCCGAG 
TGCGGGGGCC GGGTCTGTGC CTTTGATAAC CGGGCCACCG GCCGGGAGCA GGAAGCCCAG 
GTGGAGCAGC TGCTGGGGAT GGTCGAGGGC TTGGTGCTGG AGCACAAGGG CGCCCATTAC 
TCCAACGAGG TGTATGAGCT GGCGCAGGTG CTGCGCTGGG CAGGCCCTGA GGAGCGGCTC 
CGGCGGGTGG CGGAGCGCGT GGCAGCCAGG GTGCAGAGGA GGCCATGGGG CGCCTGGCTG 
TCGGCCCGGC TGTGGAAGTG GCTGAAGTCC CCCAGGAGCT GGAGGCTGGG CCTGGCCCTG 
CTGCTGGGGG GCGCGCTCCT GTTCTGGGTG CTGCTCCACA GGCGGTGGTC GGAGGCCGTT 
GCGGAGGTCG GGCCTGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570115.1
CDS	141..1061
Translation	MGGRKMATDEENVYGLEENAQSRQESTRRLILVGRTGAGKSATGNSILGQRRFFSRLGATSVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSKTDPGCEERGHCYLLSAPGPHALLLVTQLGRFTAQDQQAVRQVRDMFGEDVLKWMVIVFTRKEDLAGGSLHDYVSNTENRALRELVAECGGRVCAFDNRATGREQEAQVEQLLGMVEGLVLEHKGAHYSNEVYELAQVLRWAGPEERLRRVAERVAARVQRRPWGAWLSARLWKWLKSPRSWRLGLALLLGGALLFWVLLHRRWSEAVAEVGPD

Target ORF information:

RefSeq Version	NM_130759.3
Organism	Homo sapiens(human)
Definition	Homo sapiens GTPase, IMAP family member 1 (GIMAP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130759.3

ORF Insert Sequence:

ATGGGAGGAA GGAAGATGGC GACAGATGAA GAAAATGTCT ATGGTTTAGA AGAGAACGCT 
CAGTCCCGGC AGGAGTCCAC GCGGAGGCTC ATCCTTGTTG GGAGAACAGG GGCCGGGAAG 
AGCGCCACTG GGAACAGCAT CCTGGGCCAG AGACGGTTCT TCTCCAGGCT GGGGGCCACG 
TCTGTGACCA GGGCCTGCAC CACGGGCAGC CGCAGGTGGG ACAAGTGCCA CGTGGAAGTC 
GTGGACACTC CGGACATTTT CAGCTCCCAA GTGTCCAAGA CAGATCCTGG CTGTGAGGAG 
AGAGGTCACT GCTACCTGCT CTCGGCCCCC GGACCCCACG CGCTGCTCCT GGTGACCCAG 
TTGGGTCGGT TCACCGCCCA GGACCAGCAG GCGGTGAGGC AGGTGAGGGA CATGTTCGGG 
GAGGACGTCC TAAAATGGAT GGTCATCGTC TTCACCAGGA AGGAGGACCT GGCCGGGGGC 
TCCCTGCACG ATTACGTGAG CAACACAGAG AACCGGGCCT TGCGCGAGCT GGTGGCCGAG 
TGCGGGGGCC GGGTCTGTGC CTTTGATAAC CGGGCCACCG GCCGGGAGCA GGAAGCCCAG 
GTGGAGCAGC TGCTGGGGAT GGTCGAGGGC TTGGTGCTGG AGCACAAGGG CGCCCATTAC 
TCCAACGAGG TGTATGAGCT GGCGCAGGTG CTGCGCTGGG CAGGCCCTGA GGAGCGGCTC 
CGGCGGGTGG CGGAGCGCGT GGCAGCCAGG GTGCAGAGGA GGCCATGGGG CGCCTGGCTG 
TCGGCCCGGC TGTGGAAGTG GCTGAAGTCC CCCAGGAGCT GGAGGCTGGG CCTGGCCCTG 
CTGCTGGGGG GCGCGCTCCT GTTCTGGGTG CTGCTCCACA GGCGGTGGTC GGAGGCCGTT 
GCGGAGGTCG GGCCTGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

GIMAP1 ( NM_130759.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_570115.1 Homo sapiens GTPase, IMAP family member 1 (GIMAP1), mRNA.

Price & Availability↑

CloneID	OHu15491
Clone ID Related Accession (Same CDS sequence)	NM_130759.3 , NM_130759.4
Accession Version	NM_130759.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 921bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	GTPase IMAP family member 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA817535.1, BC040736.1, AC006479.2 and AW029312.1. On Nov 22, 2018 this sequence version replaced NM_130759.3. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. ##Evidence-Data-START## Transcript exon combination :: AK315127.1, SRR3476690.166481.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000307194.6/ ENSP00000302833.5 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGGAGGAA GGAAGATGGC GACAGATGAA GAAAATGTCT ATGGTTTAGA AGAGAACGCT 
CAGTCCCGGC AGGAGTCCAC GCGGAGGCTC ATCCTTGTTG GGAGAACAGG GGCCGGGAAG 
AGCGCCACTG GGAACAGCAT CCTGGGCCAG AGACGGTTCT TCTCCAGGCT GGGGGCCACG 
TCTGTGACCA GGGCCTGCAC CACGGGCAGC CGCAGGTGGG ACAAGTGCCA CGTGGAAGTC 
GTGGACACTC CGGACATTTT CAGCTCCCAA GTGTCCAAGA CAGATCCTGG CTGTGAGGAG 
AGAGGTCACT GCTACCTGCT CTCGGCCCCC GGACCCCACG CGCTGCTCCT GGTGACCCAG 
TTGGGTCGGT TCACCGCCCA GGACCAGCAG GCGGTGAGGC AGGTGAGGGA CATGTTCGGG 
GAGGACGTCC TAAAATGGAT GGTCATCGTC TTCACCAGGA AGGAGGACCT GGCCGGGGGC 
TCCCTGCACG ATTACGTGAG CAACACAGAG AACCGGGCCT TGCGCGAGCT GGTGGCCGAG 
TGCGGGGGCC GGGTCTGTGC CTTTGATAAC CGGGCCACCG GCCGGGAGCA GGAAGCCCAG 
GTGGAGCAGC TGCTGGGGAT GGTCGAGGGC TTGGTGCTGG AGCACAAGGG CGCCCATTAC 
TCCAACGAGG TGTATGAGCT GGCGCAGGTG CTGCGCTGGG CAGGCCCTGA GGAGCGGCTC 
CGGCGGGTGG CGGAGCGCGT GGCAGCCAGG GTGCAGAGGA GGCCATGGGG CGCCTGGCTG 
TCGGCCCGGC TGTGGAAGTG GCTGAAGTCC CCCAGGAGCT GGAGGCTGGG CCTGGCCCTG 
CTGCTGGGGG GCGCGCTCCT GTTCTGGGTG CTGCTCCACA GGCGGTGGTC GGAGGCCGTT 
GCGGAGGTCG GGCCTGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_570115.1
CDS	85..1005
Translation	MGGRKMATDEENVYGLEENAQSRQESTRRLILVGRTGAGKSATGNSILGQRRFFSRLGATSVTRACTTGSRRWDKCHVEVVDTPDIFSSQVSKTDPGCEERGHCYLLSAPGPHALLLVTQLGRFTAQDQQAVRQVRDMFGEDVLKWMVIVFTRKEDLAGGSLHDYVSNTENRALRELVAECGGRVCAFDNRATGREQEAQVEQLLGMVEGLVLEHKGAHYSNEVYELAQVLRWAGPEERLRRVAERVAARVQRRPWGAWLSARLWKWLKSPRSWRLGLALLLGGALLFWVLLHRRWSEAVAEVGPD

Target ORF information:

RefSeq Version	NM_130759.4
Organism	Homo sapiens(human)
Definition	Homo sapiens GTPase, IMAP family member 1 (GIMAP1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_130759.4

ORF Insert Sequence:

ATGGGAGGAA GGAAGATGGC GACAGATGAA GAAAATGTCT ATGGTTTAGA AGAGAACGCT 
CAGTCCCGGC AGGAGTCCAC GCGGAGGCTC ATCCTTGTTG GGAGAACAGG GGCCGGGAAG 
AGCGCCACTG GGAACAGCAT CCTGGGCCAG AGACGGTTCT TCTCCAGGCT GGGGGCCACG 
TCTGTGACCA GGGCCTGCAC CACGGGCAGC CGCAGGTGGG ACAAGTGCCA CGTGGAAGTC 
GTGGACACTC CGGACATTTT CAGCTCCCAA GTGTCCAAGA CAGATCCTGG CTGTGAGGAG 
AGAGGTCACT GCTACCTGCT CTCGGCCCCC GGACCCCACG CGCTGCTCCT GGTGACCCAG 
TTGGGTCGGT TCACCGCCCA GGACCAGCAG GCGGTGAGGC AGGTGAGGGA CATGTTCGGG 
GAGGACGTCC TAAAATGGAT GGTCATCGTC TTCACCAGGA AGGAGGACCT GGCCGGGGGC 
TCCCTGCACG ATTACGTGAG CAACACAGAG AACCGGGCCT TGCGCGAGCT GGTGGCCGAG 
TGCGGGGGCC GGGTCTGTGC CTTTGATAAC CGGGCCACCG GCCGGGAGCA GGAAGCCCAG 
GTGGAGCAGC TGCTGGGGAT GGTCGAGGGC TTGGTGCTGG AGCACAAGGG CGCCCATTAC 
TCCAACGAGG TGTATGAGCT GGCGCAGGTG CTGCGCTGGG CAGGCCCTGA GGAGCGGCTC 
CGGCGGGTGG CGGAGCGCGT GGCAGCCAGG GTGCAGAGGA GGCCATGGGG CGCCTGGCTG 
TCGGCCCGGC TGTGGAAGTG GCTGAAGTCC CCCAGGAGCT GGAGGCTGGG CCTGGCCCTG 
CTGCTGGGGG GCGCGCTCCT GTTCTGGGTG CTGCTCCACA GGCGGTGGTC GGAGGCCGTT 
GCGGAGGTCG GGCCTGACTG A

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Genome-wide association study identified copy number variants important for appendicular lean mass.
PloS one9(3)e89776(2014)
Ran S,Liu YJ,Zhang L,Pei Y,Yang TL,Hai R,Han YY,Lin Y,Tian Q,Deng HW

Putative GTPase GIMAP1 is critical for the development of mature B and T lymphocytes.
Blood115(16)3249-57(2010 Apr)
Saunders A,Webb LM,Janas ML,Hutchings A,Pascall J,Carter C,Pugh N,Morgan G,Turner M,Butcher GW

Quantitative proteomics reveals GIMAP family proteins 1 and 4 to be differentially regulated during human T helper cell differentiation.
Molecular & cellular proteomics : MCP8(1)32-44(2009 Jan)
Fil?n JJ,Fil?n S,Moulder R,Tuomela S,Ahlfors H,West A,Kouvonen P,Kantola S,Bj?rkman M,Katajamaa M,Rasool O,Nyman TA,Lahesmaa R

Comparative analysis of the human gimap gene cluster encoding a novel GTPase family.
Gene341291-304(2004 Oct)
Kr?cken J,Schroetel RM,M?ller IU,Sa?dani N,Marinovski P,Benten WP,Stamm O,Wunderlich F

Human ortholog to mouse gene imap38 encoding an ER-localizable G-protein belongs to a gene family clustered on chromosome 7q32-36.
Gene282(1-2)159-67(2002 Jan)
Stamm O,Kr?cken J,Schmitt-Wrede HP,Benten WP,Wunderlich F

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GIMAP1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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