KCNV2 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	KCNV2
Entrez Gene ID	169522
Full Name	potassium voltage-gated channel modifier subfamily V member 2
Synonyms	KV11.1,Kv8.2,RCD3B
General protein information	Preferred Names potassium voltage-gated channel modifier subfamily V member 2 Names potassium voltage-gated channel subfamily V member 2 potassium channel, subfamily V, member 2 potassium channel, voltage gated modifier subfamily V, member 2 voltage-gated potassium channel subunit Kv8.2
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 9 Map Location: 9p24.2
Summary	Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium voltage-gated channel subfamily V. This member is identified as a 'silent subunit', and it does not form homomultimers, but forms heteromultimers with several other subfamily members. Through obligatory heteromerization, it exerts a function-altering effect on other potassium channel subunits. This protein is strongly expressed in pancreas and has a weaker expression in several other tissues. [provided by RefSeq, Jul 2008].
Disorder MIM:	607604
Disorder Html:	Retinal cone dystrophy 3B, 610356 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_133497.3	NP_598004.1	potassium voltage-gated channel subfamily V member 2
NM_133497.4	NP_598004.1	potassium voltage-gated channel subfamily V member 2

Pathways from BioSystems

Homologies

Canis lupus familiaris (dog)	KCNV2	XP_851793.2
Rattus norvegicus (Norway rat)	Kcnv2	NP_001099840.1
Gallus gallus (chicken)	KCNV2	XP_429194.3
Xenopus tropicalis (tropical clawed frog)	kcnv2	XP_002934230.1
Pan troglodytes (chimpanzee)	KCNV2	XP_528530.2
Homo sapiens (human)	KCNV2	NP_598004.1
	KCNV2	XP_001086960.1
Bos taurus (cattle)	KCNV2	XP_002689669.2
Mus musculus (house mouse)	Kcnv2	NP_899002.1
Danio rerio (zebrafish)	kcnv2a	XP_695650.4

Gene Ontology
Bibliography

Related articles in PubMed

Pharmacogenetic and case-control study on potassium channel related gene variants and genetic generalized epilepsy.
Qu J, Lu SH, Lu ZL, Xu P, Xiang DX, Qu Q
Medicine96(26)e7321(2017 Jun)

Novel compound heterozygous mutations resulting in cone dystrophy with supernormal rod response.
Lenis TL, Dhrami-Gavazi E, Lee W, Mukkamala SK, Tabacaru MR, Yannuzzi L, Gouras P, Tsang SH
JAMA ophthalmology131(11)1482-5(2013 Nov)

Cone dystrophy with supernormal rod response: novel KCNV2 mutations in an underdiagnosed phenotype.
Zelinger L, Wissinger B, Eli D, Kohl S, Sharon D, Banin E
Ophthalmology120(11)2338-43(2013 Nov)

Molecular characteristics of four Japanese cases with KCNV2 retinopathy: report of novel disease-causing variants.
Fujinami K, Tsunoda K, Nakamura N, Kato Y, Noda T, Shinoda K, Tomita K, Hatase T, Usui T, Akahori M, Itabashi T, Iwata T, Ozawa Y, Tsubota K, Miyake Y
Molecular vision191580-90(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Pharmacogenetic and case-control study evaluated the role of the variants of KCNA1, KCNA2, and KCNV2 in the susceptibility and drug resistance of genetic generalized epilepsies and revealed no significant association between 8 variants of KCNA1, KCNA2, and KCNV2 genes and risk or drug resistance of genetic generalized epilepsies after a Bonferroni correction for multiple comparisons.
Title: Pharmacogenetic and case-control study on potassium channel related gene variants and genetic generalized epilepsy.

The 2 mutations identified are novel and thus expand the current knowledge of Retinal Cone Dystrophy 3B genotype-phenotype descriptions in the literature.
Title: Novel compound heterozygous mutations resulting in cone dystrophy with supernormal rod response.

This is the first report of genetic and clinical analysis of cone dystrophy with supernormal rod response in the Israeli population leading to the identification of 4 novel KCNV2 mutations.
Title: Cone dystrophy with supernormal rod response: novel KCNV2 mutations in an underdiagnosed phenotype.

Central vision parameters progressively worsen in KCNV2 cone dystrophy, structural retinal and lipofuscin accumulation abnormalities are commonly present and macular cone photoreceptor mosaic is markedly disrupted early in the disease.
Title: Phenotypic characteristics including in vivo cone photoreceptor mosaic in KCNV2-related "cone dystrophy with supernormal rod electroretinogram".

Compound heterozygosity for the two alleles of KCNV2, p.C177R and p.G461R, in three patients, and homozygosity for complex alleles, p.R27H and p.R206P, in one patient from the consanguineous family, is reported.
Title: Molecular characteristics of four Japanese cases with KCNV2 retinopathy: report of novel disease-causing variants.

The following KCNV2 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the KCNV2 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu19525	NM_133497.4 Latest version!	Homo sapiens potassium voltage-gated channel modifier subfamily V member 2 (KCNV2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
View Old Accession Versions >>
OHu19525	NM_133497.3	Homo sapiens potassium voltage-gated channel modifier subfamily V member 2 (KCNV2), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$219.50-$307.30 $439.00
Hide Old Accession Versions >>

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***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

KCNV2 ( NM_133497.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_598004.1 Homo sapiens potassium voltage-gated channel modifier subfamily V member 2 (KCNV2), mRNA.

Price & Availability↑

CloneID	OHu19525
Clone ID Related Accession (Same CDS sequence)	NM_133497.3 , NM_133497.4
Accession Version	NM_133497.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1638bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-27
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily V member 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC101352.1, BC101353.2, AF348983.1 and EL952823.1. This sequence is a reference standard in the RefSeqGene project. On Feb 25, 2011 this sequence version replaced NM_133497.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC101352.1, AF348983.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END##

ATGCTCAAAC AGAGTGAGAG GAGACGGTCC TGGAGCTACA GGCCCTGGAA CACGACGGAG 
AATGAGGGCA GCCAACACCG CAGGAGCATT TGCTCCCTGG GTGCCCGTTC CGGCTCCCAG 
GCCAGCATCC ACGGCTGGAC AGAGGGCAAC TATAACTACT ACATCGAGGA AGACGAAGAC 
GGCGAGGAGG AGGACCAGTG GAAGGACGAC CTGGCAGAAG AGGACCAGCA GGCAGGGGAG 
GTCACCACCG CCAAGCCCGA GGGCCCCAGC GACCCTCCGG CCCTGCTGTC CACGCTGAAT 
GTGAACGTGG GTGGCCACAG CTACCAGCTG GACTACTGCG AGCTGGCCGG CTTCCCCAAG 
ACGCGCCTAG GTCGCCTGGC CACCTCCACC AGCCGCAGCC GCCAGCTAAG CCTGTGCGAC 
GACTACGAGG AGCAGACAGA CGAATACTTC TTCGACCGCG ACCCGGCCGT CTTCCAGCTG 
GTCTACAATT TCTACCTGTC CGGGGTGCTG CTGGTGCTCG ACGGGCTGTG TCCGCGCCGC 
TTCCTGGAGG AGCTGGGCTA CTGGGGCGTG CGGCTCAAGT ACACGCCACG CTGCTGCCGC 
ATCTGCTTCG AGGAGCGGCG CGACGAGCTG AGCGAACGGC TCAAGATCCA GCACGAGCTG 
CGCGCGCAGG CGCAGGTCGA GGAGGCGGAG GAACTCTTCC GCGACATGCG CTTCTACGGC 
CCGCAGCGGC GCCGCCTCTG GAACCTCATG GAGAAGCCAT TCTCCTCGGT GGCCGCCAAG 
GCCATCGGGG TGGCCTCCAG CACCTTCGTG CTCGTCTCCG TGGTGGCGCT GGCGCTCAAC 
ACCGTGGAGG AGATGCAGCA GCACTCGGGG CAGGGCGAGG GCGGCCCAGA CCTGCGGCCC 
ATCCTGGAGC ACGTGGAGAT GCTGTGCATG GGCTTCTTCA CGCTCGAGTA CCTGCTGCGC 
CTAGCCTCCA CGCCCGACCT GAGGCGCTTC GCGCGCAGCG CCCTCAACCT GGTGGACCTG 
GTGGCCATCC TGCCGCTCTA CCTTCAGCTG CTGCTCGAGT GCTTCACGGG CGAGGGCCAC 
CAACGCGGCC AGACGGTGGG CAGCGTGGGT AAGGTGGGTC AGGTGTTGCG CGTCATGCGC 
CTCATGCGCA TCTTCCGCAT CCTCAAGCTG GCGCGCCACT CCACCGGACT GCGTGCCTTC 
GGCTTCACGC TGCGCCAGTG CTACCAGCAG GTGGGCTGCC TGCTGCTCTT CATCGCCATG 
GGCATCTTCA CTTTCTCTGC GGCTGTCTAC TCTGTGGAGC ACGATGTGCC CAGCACCAAC 
TTCACTACCA TCCCCCACTC CTGGTGGTGG GCCGCGGTGA GCATCTCCAC CGTGGGCTAC 
GGAGACATGT ACCCAGAGAC CCACCTGGGC AGGTTTTTTG CCTTCCTCTG CATTGCTTTT 
GGGATCATTC TCAACGGGAT GCCCATTTCC ATCCTCTACA ACAAGTTTTC TGATTACTAC 
AGCAAGCTGA AGGCTTATGA GTATACCACC ATACGCAGGG AGAGGGGAGA GGTGAACTTC 
ATGCAGAGAG CCAGAAAGAA GATAGCTGAG TGTTTGCTTG GAAGCAACCC ACAGCTCACC 
CCAAGACAAG AGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598004.1
CDS	215..1852
Translation	MLKQSERRRSWSYRPWNTTENEGSQHRRSICSLGARSGSQASIHGWTEGNYNYYIEEDEDGEEEDQWKDDLAEEDQQAGEVTTAKPEGPSDPPALLSTLNVNVGGHSYQLDYCELAGFPKTRLGRLATSTSRSRQLSLCDDYEEQTDEYFFDRDPAVFQLVYNFYLSGVLLVLDGLCPRRFLEELGYWGVRLKYTPRCCRICFEERRDELSERLKIQHELRAQAQVEEAEELFRDMRFYGPQRRRLWNLMEKPFSSVAAKAIGVASSTFVLVSVVALALNTVEEMQQHSGQGEGGPDLRPILEHVEMLCMGFFTLEYLLRLASTPDLRRFARSALNLVDLVAILPLYLQLLLECFTGEGHQRGQTVGSVGKVGQVLRVMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLLLFIAMGIFTFSAAVYSVEHDVPSTNFTTIPHSWWWAAVSISTVGYGDMYPETHLGRFFAFLCIAFGIILNGMPISILYNKFSDYYSKLKAYEYTTIRRERGEVNFMQRARKKIAECLLGSNPQLTPRQEN

Target ORF information:

RefSeq Version	NM_133497.3
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel modifier subfamily V member 2 (KCNV2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133497.3

ORF Insert Sequence:

ATGCTCAAAC AGAGTGAGAG GAGACGGTCC TGGAGCTACA GGCCCTGGAA CACGACGGAG 
AATGAGGGCA GCCAACACCG CAGGAGCATT TGCTCCCTGG GTGCCCGTTC CGGCTCCCAG 
GCCAGCATCC ACGGCTGGAC AGAGGGCAAC TATAACTACT ACATCGAGGA AGACGAAGAC 
GGCGAGGAGG AGGACCAGTG GAAGGACGAC CTGGCAGAAG AGGACCAGCA GGCAGGGGAG 
GTCACCACCG CCAAGCCCGA GGGCCCCAGC GACCCTCCGG CCCTGCTGTC CACGCTGAAT 
GTGAACGTGG GTGGCCACAG CTACCAGCTG GACTACTGCG AGCTGGCCGG CTTCCCCAAG 
ACGCGCCTAG GTCGCCTGGC CACCTCCACC AGCCGCAGCC GCCAGCTAAG CCTGTGCGAC 
GACTACGAGG AGCAGACAGA CGAATACTTC TTCGACCGCG ACCCGGCCGT CTTCCAGCTG 
GTCTACAATT TCTACCTGTC CGGGGTGCTG CTGGTGCTCG ACGGGCTGTG TCCGCGCCGC 
TTCCTGGAGG AGCTGGGCTA CTGGGGCGTG CGGCTCAAGT ACACGCCACG CTGCTGCCGC 
ATCTGCTTCG AGGAGCGGCG CGACGAGCTG AGCGAACGGC TCAAGATCCA GCACGAGCTG 
CGCGCGCAGG CGCAGGTCGA GGAGGCGGAG GAACTCTTCC GCGACATGCG CTTCTACGGC 
CCGCAGCGGC GCCGCCTCTG GAACCTCATG GAGAAGCCAT TCTCCTCGGT GGCCGCCAAG 
GCCATCGGGG TGGCCTCCAG CACCTTCGTG CTCGTCTCCG TGGTGGCGCT GGCGCTCAAC 
ACCGTGGAGG AGATGCAGCA GCACTCGGGG CAGGGCGAGG GCGGCCCAGA CCTGCGGCCC 
ATCCTGGAGC ACGTGGAGAT GCTGTGCATG GGCTTCTTCA CGCTCGAGTA CCTGCTGCGC 
CTAGCCTCCA CGCCCGACCT GAGGCGCTTC GCGCGCAGCG CCCTCAACCT GGTGGACCTG 
GTGGCCATCC TGCCGCTCTA CCTTCAGCTG CTGCTCGAGT GCTTCACGGG CGAGGGCCAC 
CAACGCGGCC AGACGGTGGG CAGCGTGGGT AAGGTGGGTC AGGTGTTGCG CGTCATGCGC 
CTCATGCGCA TCTTCCGCAT CCTCAAGCTG GCGCGCCACT CCACCGGACT GCGTGCCTTC 
GGCTTCACGC TGCGCCAGTG CTACCAGCAG GTGGGCTGCC TGCTGCTCTT CATCGCCATG 
GGCATCTTCA CTTTCTCTGC GGCTGTCTAC TCTGTGGAGC ACGATGTGCC CAGCACCAAC 
TTCACTACCA TCCCCCACTC CTGGTGGTGG GCCGCGGTGA GCATCTCCAC CGTGGGCTAC 
GGAGACATGT ACCCAGAGAC CCACCTGGGC AGGTTTTTTG CCTTCCTCTG CATTGCTTTT 
GGGATCATTC TCAACGGGAT GCCCATTTCC ATCCTCTACA ACAAGTTTTC TGATTACTAC 
AGCAAGCTGA AGGCTTATGA GTATACCACC ATACGCAGGG AGAGGGGAGA GGTGAACTTC 
ATGCAGAGAG CCAGAAAGAA GATAGCTGAG TGTTTGCTTG GAAGCAACCC ACAGCTCACC 
CCAAGACAAG AGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

KCNV2 ( NM_133497.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_598004.1 Homo sapiens potassium voltage-gated channel modifier subfamily V member 2 (KCNV2), mRNA.

Price & Availability↑

CloneID	OHu19525
Clone ID Related Accession (Same CDS sequence)	NM_133497.3 , NM_133497.4
Accession Version	NM_133497.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1638bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	potassium voltage-gated channel subfamily V member 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AL354723.17, BC101352.1, BC101353.2, AF348983.1 and EL952823.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_133497.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BC101352.1, AF348983.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968968, SAMEA2148093 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000382082.4/ ENSP00000371514.3 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGCTCAAAC AGAGTGAGAG GAGACGGTCC TGGAGCTACA GGCCCTGGAA CACGACGGAG 
AATGAGGGCA GCCAACACCG CAGGAGCATT TGCTCCCTGG GTGCCCGTTC CGGCTCCCAG 
GCCAGCATCC ACGGCTGGAC AGAGGGCAAC TATAACTACT ACATCGAGGA AGACGAAGAC 
GGCGAGGAGG AGGACCAGTG GAAGGACGAC CTGGCAGAAG AGGACCAGCA GGCAGGGGAG 
GTCACCACCG CCAAGCCCGA GGGCCCCAGC GACCCTCCGG CCCTGCTGTC CACGCTGAAT 
GTGAACGTGG GTGGCCACAG CTACCAGCTG GACTACTGCG AGCTGGCCGG CTTCCCCAAG 
ACGCGCCTAG GTCGCCTGGC CACCTCCACC AGCCGCAGCC GCCAGCTAAG CCTGTGCGAC 
GACTACGAGG AGCAGACAGA CGAATACTTC TTCGACCGCG ACCCGGCCGT CTTCCAGCTG 
GTCTACAATT TCTACCTGTC CGGGGTGCTG CTGGTGCTCG ACGGGCTGTG TCCGCGCCGC 
TTCCTGGAGG AGCTGGGCTA CTGGGGCGTG CGGCTCAAGT ACACGCCACG CTGCTGCCGC 
ATCTGCTTCG AGGAGCGGCG CGACGAGCTG AGCGAACGGC TCAAGATCCA GCACGAGCTG 
CGCGCGCAGG CGCAGGTCGA GGAGGCGGAG GAACTCTTCC GCGACATGCG CTTCTACGGC 
CCGCAGCGGC GCCGCCTCTG GAACCTCATG GAGAAGCCAT TCTCCTCGGT GGCCGCCAAG 
GCCATCGGGG TGGCCTCCAG CACCTTCGTG CTCGTCTCCG TGGTGGCGCT GGCGCTCAAC 
ACCGTGGAGG AGATGCAGCA GCACTCGGGG CAGGGCGAGG GCGGCCCAGA CCTGCGGCCC 
ATCCTGGAGC ACGTGGAGAT GCTGTGCATG GGCTTCTTCA CGCTCGAGTA CCTGCTGCGC 
CTAGCCTCCA CGCCCGACCT GAGGCGCTTC GCGCGCAGCG CCCTCAACCT GGTGGACCTG 
GTGGCCATCC TGCCGCTCTA CCTTCAGCTG CTGCTCGAGT GCTTCACGGG CGAGGGCCAC 
CAACGCGGCC AGACGGTGGG CAGCGTGGGT AAGGTGGGTC AGGTGTTGCG CGTCATGCGC 
CTCATGCGCA TCTTCCGCAT CCTCAAGCTG GCGCGCCACT CCACCGGACT GCGTGCCTTC 
GGCTTCACGC TGCGCCAGTG CTACCAGCAG GTGGGCTGCC TGCTGCTCTT CATCGCCATG 
GGCATCTTCA CTTTCTCTGC GGCTGTCTAC TCTGTGGAGC ACGATGTGCC CAGCACCAAC 
TTCACTACCA TCCCCCACTC CTGGTGGTGG GCCGCGGTGA GCATCTCCAC CGTGGGCTAC 
GGAGACATGT ACCCAGAGAC CCACCTGGGC AGGTTTTTTG CCTTCCTCTG CATTGCTTTT 
GGGATCATTC TCAACGGGAT GCCCATTTCC ATCCTCTACA ACAAGTTTTC TGATTACTAC 
AGCAAGCTGA AGGCTTATGA GTATACCACC ATACGCAGGG AGAGGGGAGA GGTGAACTTC 
ATGCAGAGAG CCAGAAAGAA GATAGCTGAG TGTTTGCTTG GAAGCAACCC ACAGCTCACC 
CCAAGACAAG AGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_598004.1
CDS	231..1868
Translation	MLKQSERRRSWSYRPWNTTENEGSQHRRSICSLGARSGSQASIHGWTEGNYNYYIEEDEDGEEEDQWKDDLAEEDQQAGEVTTAKPEGPSDPPALLSTLNVNVGGHSYQLDYCELAGFPKTRLGRLATSTSRSRQLSLCDDYEEQTDEYFFDRDPAVFQLVYNFYLSGVLLVLDGLCPRRFLEELGYWGVRLKYTPRCCRICFEERRDELSERLKIQHELRAQAQVEEAEELFRDMRFYGPQRRRLWNLMEKPFSSVAAKAIGVASSTFVLVSVVALALNTVEEMQQHSGQGEGGPDLRPILEHVEMLCMGFFTLEYLLRLASTPDLRRFARSALNLVDLVAILPLYLQLLLECFTGEGHQRGQTVGSVGKVGQVLRVMRLMRIFRILKLARHSTGLRAFGFTLRQCYQQVGCLLLFIAMGIFTFSAAVYSVEHDVPSTNFTTIPHSWWWAAVSISTVGYGDMYPETHLGRFFAFLCIAFGIILNGMPISILYNKFSDYYSKLKAYEYTTIRRERGEVNFMQRARKKIAECLLGSNPQLTPRQEN

Target ORF information:

RefSeq Version	NM_133497.4
Organism	Homo sapiens(human)
Definition	Homo sapiens potassium voltage-gated channel modifier subfamily V member 2 (KCNV2), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_133497.4

ORF Insert Sequence:

ATGCTCAAAC AGAGTGAGAG GAGACGGTCC TGGAGCTACA GGCCCTGGAA CACGACGGAG 
AATGAGGGCA GCCAACACCG CAGGAGCATT TGCTCCCTGG GTGCCCGTTC CGGCTCCCAG 
GCCAGCATCC ACGGCTGGAC AGAGGGCAAC TATAACTACT ACATCGAGGA AGACGAAGAC 
GGCGAGGAGG AGGACCAGTG GAAGGACGAC CTGGCAGAAG AGGACCAGCA GGCAGGGGAG 
GTCACCACCG CCAAGCCCGA GGGCCCCAGC GACCCTCCGG CCCTGCTGTC CACGCTGAAT 
GTGAACGTGG GTGGCCACAG CTACCAGCTG GACTACTGCG AGCTGGCCGG CTTCCCCAAG 
ACGCGCCTAG GTCGCCTGGC CACCTCCACC AGCCGCAGCC GCCAGCTAAG CCTGTGCGAC 
GACTACGAGG AGCAGACAGA CGAATACTTC TTCGACCGCG ACCCGGCCGT CTTCCAGCTG 
GTCTACAATT TCTACCTGTC CGGGGTGCTG CTGGTGCTCG ACGGGCTGTG TCCGCGCCGC 
TTCCTGGAGG AGCTGGGCTA CTGGGGCGTG CGGCTCAAGT ACACGCCACG CTGCTGCCGC 
ATCTGCTTCG AGGAGCGGCG CGACGAGCTG AGCGAACGGC TCAAGATCCA GCACGAGCTG 
CGCGCGCAGG CGCAGGTCGA GGAGGCGGAG GAACTCTTCC GCGACATGCG CTTCTACGGC 
CCGCAGCGGC GCCGCCTCTG GAACCTCATG GAGAAGCCAT TCTCCTCGGT GGCCGCCAAG 
GCCATCGGGG TGGCCTCCAG CACCTTCGTG CTCGTCTCCG TGGTGGCGCT GGCGCTCAAC 
ACCGTGGAGG AGATGCAGCA GCACTCGGGG CAGGGCGAGG GCGGCCCAGA CCTGCGGCCC 
ATCCTGGAGC ACGTGGAGAT GCTGTGCATG GGCTTCTTCA CGCTCGAGTA CCTGCTGCGC 
CTAGCCTCCA CGCCCGACCT GAGGCGCTTC GCGCGCAGCG CCCTCAACCT GGTGGACCTG 
GTGGCCATCC TGCCGCTCTA CCTTCAGCTG CTGCTCGAGT GCTTCACGGG CGAGGGCCAC 
CAACGCGGCC AGACGGTGGG CAGCGTGGGT AAGGTGGGTC AGGTGTTGCG CGTCATGCGC 
CTCATGCGCA TCTTCCGCAT CCTCAAGCTG GCGCGCCACT CCACCGGACT GCGTGCCTTC 
GGCTTCACGC TGCGCCAGTG CTACCAGCAG GTGGGCTGCC TGCTGCTCTT CATCGCCATG 
GGCATCTTCA CTTTCTCTGC GGCTGTCTAC TCTGTGGAGC ACGATGTGCC CAGCACCAAC 
TTCACTACCA TCCCCCACTC CTGGTGGTGG GCCGCGGTGA GCATCTCCAC CGTGGGCTAC 
GGAGACATGT ACCCAGAGAC CCACCTGGGC AGGTTTTTTG CCTTCCTCTG CATTGCTTTT 
GGGATCATTC TCAACGGGAT GCCCATTTCC ATCCTCTACA ACAAGTTTTC TGATTACTAC 
AGCAAGCTGA AGGCTTATGA GTATACCACC ATACGCAGGG AGAGGGGAGA GGTGAACTTC 
ATGCAGAGAG CCAGAAAGAA GATAGCTGAG TGTTTGCTTG GAAGCAACCC ACAGCTCACC 
CCAAGACAAG AGAATTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Pharmacogenetic and case-control study on potassium channel related gene variants and genetic generalized epilepsy.
Medicine96(26)e7321(2017 Jun)
Qu J,Lu SH,Lu ZL,Xu P,Xiang DX,Qu Q

Novel compound heterozygous mutations resulting in cone dystrophy with supernormal rod response.
JAMA ophthalmology131(11)1482-5(2013 Nov)
Lenis TL,Dhrami-Gavazi E,Lee W,Mukkamala SK,Tabacaru MR,Yannuzzi L,Gouras P,Tsang SH

Cone dystrophy with supernormal rod response: novel KCNV2 mutations in an underdiagnosed phenotype.
Ophthalmology120(11)2338-43(2013 Nov)
Zelinger L,Wissinger B,Eli D,Kohl S,Sharon D,Banin E

Molecular characteristics of four Japanese cases with KCNV2 retinopathy: report of novel disease-causing variants.
Molecular vision191580-90(2013)
Fujinami K,Tsunoda K,Nakamura N,Kato Y,Noda T,Shinoda K,Tomita K,Hatase T,Usui T,Akahori M,Itabashi T,Iwata T,Ozawa Y,Tsubota K,Miyake Y

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KCNV2 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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