BHLHA15 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	BHLHA15
Entrez Gene ID	168620
Full Name	basic helix-loop-helix family member a15
Synonyms	BHLHB8,MIST1
General protein information	Preferred Names basic helix-loop-helix family member a15 Names class A basic helix-loop-helix protein 15 MIST-1 basic helix-loop-helix domain containing, class B, 8 class B basic helix-loop-helix protein 8 class II bHLH protein MIST1 muscle, intestine and stomach expression 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 7 Map Location: 7q21.3
Disorder MIM:	608606

mRNA and Protein(s)

mRNA	Protein	Name
NM_177455.3	NP_803238.1	class A basic helix-loop-helix protein 15

Pathways from BioSystems

Homologies

Homo sapiens (human)	BHLHA15	NP_803238.1
Canis lupus familiaris (dog)	BHLHA15	XP_005621166.1
Rattus norvegicus (Norway rat)	Bhlha15	NP_036995.1
Pan troglodytes (chimpanzee)	BHLHA15	XP_527829.1
Bos taurus (cattle)	BHLHA15	XP_005225330.1
Mus musculus (house mouse)	Bhlha15	NP_034930.1

Gene Ontology
Bibliography

Related articles in PubMed

MIST1-a novel marker of plasmacytic differentiation.
Yeung CC, Mills JC, Hassan A, Kreisel FH, Nguyen TT, Frater JL
Applied immunohistochemistry & molecular morphology : AIMM20(6)561-5(2012 Dec)

Activation of protein kinase C? leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1.
Johnson CL, Peat JM, Volante SN, Wang R, McLean CA, Pin CL
The Journal of pathology228(3)351-65(2012 Nov)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

noted a higher mean value of microvascular density in CK5/6 and Ep-CAM-immunopositive tumors, carcinomas with aberrant CK8/18 expression, and carcinomas with no or strong expression of MMP-2 in stromal fibroblast-like cells
Title: MIST1-a novel marker of plasmacytic differentiation.

Activation of protein kinase Cdelta leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1.
Title: Activation of protein kinase C? leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1.

Chief cells emerge from the Mist.
Title: The origin of pre-neoplastic metaplasia in the stomach: chief cells emerge from the Mist.

MIST1 is enriched upon plasma cell differentiation.
Title: Transcription factor MIST1 in terminal differentiation of mouse and human plasma cells.

Our findings implicate MIST1 as a reliable marker of mature, healthy chief cells, and we provide the first evidence that metaplasia in humans arises at least in part from the chief cell lineage.
Title: The transcription factor MIST1 is a novel human gastric chief cell marker whose expression is lost in metaplasia, dysplasia, and carcinoma.

The following BHLHA15 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the BHLHA15 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu31215	NM_177455.3 Latest version!	Homo sapiens basic helix-loop-helix family member a15 (BHLHA15), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

BHLHA15 ( NM_177455.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_803238.1 Homo sapiens basic helix-loop-helix family member a15 (BHLHA15), mRNA.

Price & Availability↑

CloneID	OHu31215
Clone ID Related Accession (Same CDS sequence)	NM_177455.3
Accession Version	NM_177455.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 570bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-23
Organism	Homo sapiens(human)
Product	class A basic helix-loop-helix protein 15
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC113396.1. On Oct 25, 2006 this sequence version replaced NM_177455.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC113396.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGAAGACCA AGAACCGGCC CCCACGGCGC CGGGCCCCGG TGCAGGACAC AGAGGCCACC 
CCCGGGGAGG GGACGCCCGA CGGGTCCCTG CCGAACCCGG GGCCAGAGCC GGCCAAGGGT 
CTGCGGAGCC GGCCGGCCCG GGCCGCAGCA AGGGCTCCGG GCGAGGGCAG GCGCAGGCGG 
CCAGGACCCT CCGGGCCCGG TGGCCGTCGT GACAGCAGCA TCCAGCGGCG GCTGGAGAGC 
AACGAGAGGG AGCGGCAGCG GATGCACAAG CTAAATAACG CCTTCCAGGC CCTGCGTGAA 
GTCATCCCCC ACGTGCGCGC GGACAAGAAG CTCTCCAAGA TCGAGACGCT CACGCTGGCC 
AAGAACTACA TCAAATCGCT GACGGCCACC ATCCTGACCA TGTCCAGCAG CCGCCTCCCA 
GGCCTGGAGG GGCCGGGCCC CAAGCTCTAC CAGCACTACC AGCAGCAGCA GCAGGTGGCT 
GGGGGTGCGT TGGGGGCCAC GGAGGCCCAG CCCCAGGGCC ACCTGCAGAG GTACTCCACG 
CAGATCCACA GCTTCCGAGA GGGCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_803238.1
CDS	57..626
Translation	MKTKNRPPRRRAPVQDTEATPGEGTPDGSLPNPGPEPAKGLRSRPARAAARAPGEGRRRRPGPSGPGGRRDSSIQRRLESNERERQRMHKLNNAFQALREVIPHVRADKKLSKIETLTLAKNYIKSLTATILTMSSSRLPGLEGPGPKLYQHYQQQQQVAGGALGATEAQPQGHLQRYSTQIHSFREGT

Target ORF information:

RefSeq Version	NM_177455.3
Organism	Homo sapiens(human)
Definition	Homo sapiens basic helix-loop-helix family member a15 (BHLHA15), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_177455.3

ORF Insert Sequence:

ATGAAGACCA AGAACCGGCC CCCACGGCGC CGGGCCCCGG TGCAGGACAC AGAGGCCACC 
CCCGGGGAGG GGACGCCCGA CGGGTCCCTG CCGAACCCGG GGCCAGAGCC GGCCAAGGGT 
CTGCGGAGCC GGCCGGCCCG GGCCGCAGCA AGGGCTCCGG GCGAGGGCAG GCGCAGGCGG 
CCAGGACCCT CCGGGCCCGG TGGCCGTCGT GACAGCAGCA TCCAGCGGCG GCTGGAGAGC 
AACGAGAGGG AGCGGCAGCG GATGCACAAG CTAAATAACG CCTTCCAGGC CCTGCGTGAA 
GTCATCCCCC ACGTGCGCGC GGACAAGAAG CTCTCCAAGA TCGAGACGCT CACGCTGGCC 
AAGAACTACA TCAAATCGCT GACGGCCACC ATCCTGACCA TGTCCAGCAG CCGCCTCCCA 
GGCCTGGAGG GGCCGGGCCC CAAGCTCTAC CAGCACTACC AGCAGCAGCA GCAGGTGGCT 
GGGGGTGCGT TGGGGGCCAC GGAGGCCCAG CCCCAGGGCC ACCTGCAGAG GTACTCCACG 
CAGATCCACA GCTTCCGAGA GGGCACCTAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

MIST1-a novel marker of plasmacytic differentiation.
Applied immunohistochemistry & molecular morphology : AIMM20(6)561-5(2012 Dec)
Yeung CC,Mills JC,Hassan A,Kreisel FH,Nguyen TT,Frater JL

Activation of protein kinase C? leads to increased pancreatic acinar cell dedifferentiation in the absence of MIST1.
The Journal of pathology228(3)351-65(2012 Nov)
Johnson CL,Peat JM,Volante SN,Wang R,McLean CA,Pin CL