CFD cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	CFD
Entrez Gene ID	1675
Full Name	complement factor D
Synonyms	ADIPSIN,ADN,DF,PFD
General protein information	Preferred Names complement factor D Names complement factor D C3 convertase activator D component of complement (adipsin) complement factor D preproprotein properdin factor D
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 19 Map Location: 19p13.3
Summary	This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015].
Disorder MIM:	134350
Disorder Html:	Complement factor D deficiency, 613912 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001317335.2	NP_001304264.1	complement factor D isoform 2 precursor
NM_001928.2	NP_001919.2	complement factor D preproprotein
NM_001928.3	NP_001919.2	complement factor D isoform 1 preproprotein
NM_001317335.1	NP_001304264.1	complement factor D isoform 2 precursor
NM_001928.4	NP_001919.2	complement factor D isoform 1 preproprotein

Pathways from BioSystems

Homologies

Pan troglodytes (chimpanzee)	CFD	XP_003953351.1
Mus musculus (house mouse)	Cfd	NP_038487.1
Rattus norvegicus (Norway rat)	Cfd	NP_001071110.1
	LOC721138	XP_001117186.2
Gallus gallus (chicken)	CFD	XP_003642908.2
Homo sapiens (human)	CFD	NP_001919.2
Danio rerio (zebrafish)	cfd	NP_001018368.1
Canis lupus familiaris (dog)	CFD	XP_005633220.1
Bos taurus (cattle)	CFD	NP_001029427.1
Xenopus tropicalis (tropical clawed frog)	cfd	NP_989320.1

Gene Ontology
Bibliography

Related articles in PubMed

Associations between Th17-related inflammatory cytokines and asthma in adults: A Case-Control Study.
Zhou T, Huang X, Zhou Y, Ma J, Zhou M, Liu Y, Xiao L, Yuan J, Xie J, Chen W
Scientific reports7(1)15502(2017 Nov)

The role of production of adipsin and leptin in the development of insulin resistance in patients with abdominal obesity.
Vasilenko MA, Kirienkova EV, Skuratovskaia DA, Zatolokin PA, Mironyuk NI, Litvinova LS
Doklady. Biochemistry and biophysics475(1)271-276(2017 Jul)

Thiazolidinediones abrogate cervical cancer growth.
Wuertz BR, Darrah L, Wudel J, Ondrey FG
Experimental cell research353(2)63-71(2017 04)

Associating genetic variation at Perilipin 1, Complement Factor D and Adiponectin loci to the bone health status in North Indian population.
Sandhu HS, Puri S, Sharma R, Sokhi J, Singh G, Matharoo K, Bhanwer A
Gene61080-89(2017 Apr)

MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked.
Dob? J, Szak?cs D, Oroszl?n G, Kortvely E, Kiss B, Boros E, Sz?sz R, Z?vodszky P, G?l P, P?l G
Scientific reports631877(2016 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

disturbance of reciprocal relationships between adipsin and leptin in obesity is associated with the development of insulin resistance
Title: The role of production of adipsin and leptin in the development of insulin resistance in patients with abdominal obesity.

TZDs (pioglitazone, rosiglitazone, and ciglitazone) slow tumor cell growth in vitro and in vivo with decreases in cell proliferation and increases in PPARg and adipsin
Title: Thiazolidinediones abrogate cervical cancer growth.

The strong association of PLIN1, CFD and ADIPOQ genes with adipogenesis prompted authors to study the influence the bone health status as evaluated by quantitative ultrasound (QUS) bone densitometer in a North Indian cohort. Overall, ADIPOQ (rs1501299 and rs3774261) and combined cluster of PLIN1 rs2304796 and rs2304795) and CFD (rs1683563) demonstrated correlation.
Title: Associating genetic variation at Perilipin 1, Complement Factor D and Adiponectin loci to the bone health status in North Indian population.

our findings set up a novel mechanism for FABP4, adipsin and adiponectin through gut microbiota mediating expression in gut Paneth cells.
Title: Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus.

Overall adipsin levels among male asbestos industry workers were significantly higher than among control subjects.
Title: Plasma adipokine levels in Thais.

The following CFD gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the CFD cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu101748	NM_001317335.2 Latest version!	Homo sapiens complement factor D (CFD), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu18206	NM_001928.4 Latest version!	Homo sapiens complement factor D (CFD), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu18206	NM_001928.2	Homo sapiens complement factor D (adipsin) (CFD), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
OHu101748	NM_001317335.1	Homo sapiens complement factor D (CFD), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu18206	NM_001928.3	Homo sapiens complement factor D (CFD), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

CFD ( NM_001317335.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304264.1 Homo sapiens complement factor D (CFD), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu101748
Clone ID Related Accession (Same CDS sequence)	NM_001317335.2 , NM_001317335.1
Accession Version	NM_001317335.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-03
Organism	Homo sapiens(human)
Product	complement factor D isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DA008405.1, DQ884409.1, HY281047.1, M84526.1 and AC112706.2. On May 31, 2019 this sequence version replaced NM_001317335.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter and contains a distinct predicted signal peptide compared to isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DRR138524.1262486.1, DRR138525.146469.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCACAGCT GGGAGCGCCT GGCAGTTCTG GTCCTCCTAG GAGCGGCCGC CTGCGGTGAG 
GAGGCCTGGG CCTGGGCGGC GCCGCCCCGT GGTCGGATCC TGGGCGGCAG AGAGGCCGAG 
GCGCACGCGC GGCCCTACAT GGCGTCGGTG CAGCTGAACG GCGCGCACCT GTGCGGCGGC 
GTCCTGGTGG CGGAGCAGTG GGTGCTGAGC GCGGCGCACT GCCTGGAGGA CGCGGCCGAC 
GGGAAGGTGC AGGTTCTCCT GGGCGCGCAC TCCCTGTCGC AGCCGGAGCC CTCCAAGCGC 
CTGTACGACG TGCTCCGCGC AGTGCCCCAC CCGGACAGCC AGCCCGACAC CATCGACCAC 
GACCTCCTGC TGCTACAGCT GTCGGAGAAG GCCACACTGG GCCCTGCTGT GCGCCCCCTG 
CCCTGGCAGC GCGTGGACCG CGACGTGGCA CCGGGAACTC TCTGCGACGT GGCCGGCTGG 
GGCATAGTCA ACCACGCGGG CCGCCGCCCG GACAGCCTGC AGCACGTGCT CTTGCCAGTG 
CTGGACCGCG CCACCTGCAA CCGGCGCACG CACCACGACG GCGCCATCAC CGAGCGCTTG 
ATGTGCGCGG AGAGCAATCG CCGGGACAGC TGCAAGGGTG ACTCCGGGGG CCCGCTGGTG 
TGCGGGGGCG TGCTCGAGGG CGTGGTCACC TCGGGCTCGC GCGTTTGCGG CAACCGCAAG 
AAGCCCGGGA TCTACACCCG CGTGGCGAGC TATGCGGCCT GGATCGACAG CGTCCTGGCC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304264.1
CDS	27..809
Translation	MHSWERLAVLVLLGAAACGEEAWAWAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

Target ORF information:

RefSeq Version	NM_001317335.2
Organism	Homo sapiens(human)
Definition	Homo sapiens complement factor D (CFD), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317335.2

ORF Insert Sequence:

ATGCACAGCT GGGAGCGCCT GGCAGTTCTG GTCCTCCTAG GAGCGGCCGC CTGCGGTGAG 
GAGGCCTGGG CCTGGGCGGC GCCGCCCCGT GGTCGGATCC TGGGCGGCAG AGAGGCCGAG 
GCGCACGCGC GGCCCTACAT GGCGTCGGTG CAGCTGAACG GCGCGCACCT GTGCGGCGGC 
GTCCTGGTGG CGGAGCAGTG GGTGCTGAGC GCGGCGCACT GCCTGGAGGA CGCGGCCGAC 
GGGAAGGTGC AGGTTCTCCT GGGCGCGCAC TCCCTGTCGC AGCCGGAGCC CTCCAAGCGC 
CTGTACGACG TGCTCCGCGC AGTGCCCCAC CCGGACAGCC AGCCCGACAC CATCGACCAC 
GACCTCCTGC TGCTACAGCT GTCGGAGAAG GCCACACTGG GCCCTGCTGT GCGCCCCCTG 
CCCTGGCAGC GCGTGGACCG CGACGTGGCA CCGGGAACTC TCTGCGACGT GGCCGGCTGG 
GGCATAGTCA ACCACGCGGG CCGCCGCCCG GACAGCCTGC AGCACGTGCT CTTGCCAGTG 
CTGGACCGCG CCACCTGCAA CCGGCGCACG CACCACGACG GCGCCATCAC CGAGCGCTTG 
ATGTGCGCGG AGAGCAATCG CCGGGACAGC TGCAAGGGTG ACTCCGGGGG CCCGCTGGTG 
TGCGGGGGCG TGCTCGAGGG CGTGGTCACC TCGGGCTCGC GCGTTTGCGG CAACCGCAAG 
AAGCCCGGGA TCTACACCCG CGTGGCGAGC TATGCGGCCT GGATCGACAG CGTCCTGGCC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CFD ( NM_001317335.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001304264.1 Homo sapiens complement factor D (CFD), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu101748
Clone ID Related Accession (Same CDS sequence)	NM_001317335.2 , NM_001317335.1
Accession Version	NM_001317335.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 783bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	complement factor D isoform 2 precursor
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY087483.1, DA008405.1, DQ884409.1, HY281047.1 and M84526.1. Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter and contains a distinct predicted signal peptide compared to isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: DQ884409.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA2142348 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCACAGCT GGGAGCGCCT GGCAGTTCTG GTCCTCCTAG GAGCGGCCGC CTGCGGTGAG 
GAGGCCTGGG CCTGGGCGGC GCCGCCCCGT GGTCGGATCC TGGGCGGCAG AGAGGCCGAG 
GCGCACGCGC GGCCCTACAT GGCGTCGGTG CAGCTGAACG GCGCGCACCT GTGCGGCGGC 
GTCCTGGTGG CGGAGCAGTG GGTGCTGAGC GCGGCGCACT GCCTGGAGGA CGCGGCCGAC 
GGGAAGGTGC AGGTTCTCCT GGGCGCGCAC TCCCTGTCGC AGCCGGAGCC CTCCAAGCGC 
CTGTACGACG TGCTCCGCGC AGTGCCCCAC CCGGACAGCC AGCCCGACAC CATCGACCAC 
GACCTCCTGC TGCTACAGCT GTCGGAGAAG GCCACACTGG GCCCTGCTGT GCGCCCCCTG 
CCCTGGCAGC GCGTGGACCG CGACGTGGCA CCGGGAACTC TCTGCGACGT GGCCGGCTGG 
GGCATAGTCA ACCACGCGGG CCGCCGCCCG GACAGCCTGC AGCACGTGCT CTTGCCAGTG 
CTGGACCGCG CCACCTGCAA CCGGCGCACG CACCACGACG GCGCCATCAC CGAGCGCTTG 
ATGTGCGCGG AGAGCAATCG CCGGGACAGC TGCAAGGGTG ACTCCGGGGG CCCGCTGGTG 
TGCGGGGGCG TGCTCGAGGG CGTGGTCACC TCGGGCTCGC GCGTTTGCGG CAACCGCAAG 
AAGCCCGGGA TCTACACCCG CGTGGCGAGC TATGCGGCCT GGATCGACAG CGTCCTGGCC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001304264.1
CDS	32..814
Translation	MHSWERLAVLVLLGAAACGEEAWAWAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

Target ORF information:

RefSeq Version	NM_001317335.1
Organism	Homo sapiens(human)
Definition	Homo sapiens complement factor D (CFD), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001317335.1

ORF Insert Sequence:

ATGCACAGCT GGGAGCGCCT GGCAGTTCTG GTCCTCCTAG GAGCGGCCGC CTGCGGTGAG 
GAGGCCTGGG CCTGGGCGGC GCCGCCCCGT GGTCGGATCC TGGGCGGCAG AGAGGCCGAG 
GCGCACGCGC GGCCCTACAT GGCGTCGGTG CAGCTGAACG GCGCGCACCT GTGCGGCGGC 
GTCCTGGTGG CGGAGCAGTG GGTGCTGAGC GCGGCGCACT GCCTGGAGGA CGCGGCCGAC 
GGGAAGGTGC AGGTTCTCCT GGGCGCGCAC TCCCTGTCGC AGCCGGAGCC CTCCAAGCGC 
CTGTACGACG TGCTCCGCGC AGTGCCCCAC CCGGACAGCC AGCCCGACAC CATCGACCAC 
GACCTCCTGC TGCTACAGCT GTCGGAGAAG GCCACACTGG GCCCTGCTGT GCGCCCCCTG 
CCCTGGCAGC GCGTGGACCG CGACGTGGCA CCGGGAACTC TCTGCGACGT GGCCGGCTGG 
GGCATAGTCA ACCACGCGGG CCGCCGCCCG GACAGCCTGC AGCACGTGCT CTTGCCAGTG 
CTGGACCGCG CCACCTGCAA CCGGCGCACG CACCACGACG GCGCCATCAC CGAGCGCTTG 
ATGTGCGCGG AGAGCAATCG CCGGGACAGC TGCAAGGGTG ACTCCGGGGG CCCGCTGGTG 
TGCGGGGGCG TGCTCGAGGG CGTGGTCACC TCGGGCTCGC GCGTTTGCGG CAACCGCAAG 
AAGCCCGGGA TCTACACCCG CGTGGCGAGC TATGCGGCCT GGATCGACAG CGTCCTGGCC 
TAG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CFD ( NM_001928.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001919.2 Homo sapiens complement factor D (adipsin) (CFD), mRNA.

Price & Availability↑

CloneID	OHu18206
Clone ID Related Accession (Same CDS sequence)	NM_001928.2 , NM_001928.3 , NM_001928.4
Accession Version	NM_001928.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 762bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2015-03-14
Organism	Homo sapiens(Human)
Product	complement factor D preproprotein
Comment

ATGCACAGCT GGGAGCGCCT GGCAGTTCTG GTCCTCCTAG GAGCGGCCGC CTGCGCGGCG 
CCGCCCCGTG GTCGGATCCT GGGCGGCAGA GAGGCCGAGG CGCACGCGCG GCCCTACATG 
GCGTCGGTGC AGCTGAACGG CGCGCACCTG TGCGGCGGCG TCCTGGTGGC GGAGCAGTGG 
GTGCTGAGCG CGGCGCACTG CCTGGAGGAC GCGGCCGACG GGAAGGTGCA GGTTCTCCTG 
GGCGCGCACT CCCTGTCGCA GCCGGAGCCC TCCAAGCGCC TGTACGACGT GCTCCGCGCA 
GTGCCCCACC CGGACAGCCA GCCCGACACC ATCGACCACG ACCTCCTGCT GCTACAGCTG 
TCGGAGAAGG CCACACTGGG CCCTGCTGTG CGCCCCCTGC CCTGGCAGCG CGTGGACCGC 
GACGTGGCAC CGGGAACTCT CTGCGACGTG GCCGGCTGGG GCATAGTCAA CCACGCGGGC 
CGCCGCCCGG ACAGCCTGCA GCACGTGCTC TTGCCAGTGC TGGACCGCGC CACCTGCAAC 
CGGCGCACGC ACCACGACGG CGCCATCACC GAGCGCTTGA TGTGCGCGGA GAGCAATCGC 
CGGGACAGCT GCAAGGGTGA CTCCGGGGGC CCGCTGGTGT GCGGGGGCGT GCTCGAGGGC 
GTGGTCACCT CGGGCTCGCG CGTTTGCGGC AACCGCAAGA AGCCCGGGAT CTACACCCGC 
GTGGCGAGCT ATGCGGCCTG GATCGACAGC GTCCTGGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001919.2
Translation	MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

Target ORF information:

RefSeq Version	NM_001928.2
Organism	Homo sapiens(Human)
Definition	Homo sapiens complement factor D (adipsin) (CFD), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001928.2

ORF Insert Sequence:

ATGCACAGCT GGGAGCGCCT GGCAGTTCTG GTCCTCCTAG GAGCGGCCGC CTGCGCGGCG 
CCGCCCCGTG GTCGGATCCT GGGCGGCAGA GAGGCCGAGG CGCACGCGCG GCCCTACATG 
GCGTCGGTGC AGCTGAACGG CGCGCACCTG TGCGGCGGCG TCCTGGTGGC GGAGCAGTGG 
GTGCTGAGCG CGGCGCACTG CCTGGAGGAC GCGGCCGACG GGAAGGTGCA GGTTCTCCTG 
GGCGCGCACT CCCTGTCGCA GCCGGAGCCC TCCAAGCGCC TGTACGACGT GCTCCGCGCA 
GTGCCCCACC CGGACAGCCA GCCCGACACC ATCGACCACG ACCTCCTGCT GCTACAGCTG 
TCGGAGAAGG CCACACTGGG CCCTGCTGTG CGCCCCCTGC CCTGGCAGCG CGTGGACCGC 
GACGTGGCAC CGGGAACTCT CTGCGACGTG GCCGGCTGGG GCATAGTCAA CCACGCGGGC 
CGCCGCCCGG ACAGCCTGCA GCACGTGCTC TTGCCAGTGC TGGACCGCGC CACCTGCAAC 
CGGCGCACGC ACCACGACGG CGCCATCACC GAGCGCTTGA TGTGCGCGGA GAGCAATCGC 
CGGGACAGCT GCAAGGGTGA CTCCGGGGGC CCGCTGGTGT GCGGGGGCGT GCTCGAGGGC 
GTGGTCACCT CGGGCTCGCG CGTTTGCGGC AACCGCAAGA AGCCCGGGAT CTACACCCGC 
GTGGCGAGCT ATGCGGCCTG GATCGACAGC GTCCTGGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CFD ( NM_001928.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001919.2 Homo sapiens complement factor D (CFD), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu18206
Clone ID Related Accession (Same CDS sequence)	NM_001928.2 , NM_001928.3 , NM_001928.4
Accession Version	NM_001928.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 762bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-24
Organism	Homo sapiens(human)
Product	complement factor D isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY087483.1, BC057807.1, HY281047.1 and M84526.1. On Nov 28, 2015 this sequence version replaced NM_001928.2. Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M84526.1, ERR279845.2182.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCACAGCT GGGAGCGCCT GGCAGTTCTG GTCCTCCTAG GAGCGGCCGC CTGCGCGGCG 
CCGCCCCGTG GTCGGATCCT GGGCGGCAGA GAGGCCGAGG CGCACGCGCG GCCCTACATG 
GCGTCGGTGC AGCTGAACGG CGCGCACCTG TGCGGCGGCG TCCTGGTGGC GGAGCAGTGG 
GTGCTGAGCG CGGCGCACTG CCTGGAGGAC GCGGCCGACG GGAAGGTGCA GGTTCTCCTG 
GGCGCGCACT CCCTGTCGCA GCCGGAGCCC TCCAAGCGCC TGTACGACGT GCTCCGCGCA 
GTGCCCCACC CGGACAGCCA GCCCGACACC ATCGACCACG ACCTCCTGCT GCTACAGCTG 
TCGGAGAAGG CCACACTGGG CCCTGCTGTG CGCCCCCTGC CCTGGCAGCG CGTGGACCGC 
GACGTGGCAC CGGGAACTCT CTGCGACGTG GCCGGCTGGG GCATAGTCAA CCACGCGGGC 
CGCCGCCCGG ACAGCCTGCA GCACGTGCTC TTGCCAGTGC TGGACCGCGC CACCTGCAAC 
CGGCGCACGC ACCACGACGG CGCCATCACC GAGCGCTTGA TGTGCGCGGA GAGCAATCGC 
CGGGACAGCT GCAAGGGTGA CTCCGGGGGC CCGCTGGTGT GCGGGGGCGT GCTCGAGGGC 
GTGGTCACCT CGGGCTCGCG CGTTTGCGGC AACCGCAAGA AGCCCGGGAT CTACACCCGC 
GTGGCGAGCT ATGCGGCCTG GATCGACAGC GTCCTGGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001919.2
CDS	32..793
Translation	MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

Target ORF information:

RefSeq Version	NM_001928.3
Organism	Homo sapiens(human)
Definition	Homo sapiens complement factor D (CFD), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001928.3

ORF Insert Sequence:

ATGCACAGCT GGGAGCGCCT GGCAGTTCTG GTCCTCCTAG GAGCGGCCGC CTGCGCGGCG 
CCGCCCCGTG GTCGGATCCT GGGCGGCAGA GAGGCCGAGG CGCACGCGCG GCCCTACATG 
GCGTCGGTGC AGCTGAACGG CGCGCACCTG TGCGGCGGCG TCCTGGTGGC GGAGCAGTGG 
GTGCTGAGCG CGGCGCACTG CCTGGAGGAC GCGGCCGACG GGAAGGTGCA GGTTCTCCTG 
GGCGCGCACT CCCTGTCGCA GCCGGAGCCC TCCAAGCGCC TGTACGACGT GCTCCGCGCA 
GTGCCCCACC CGGACAGCCA GCCCGACACC ATCGACCACG ACCTCCTGCT GCTACAGCTG 
TCGGAGAAGG CCACACTGGG CCCTGCTGTG CGCCCCCTGC CCTGGCAGCG CGTGGACCGC 
GACGTGGCAC CGGGAACTCT CTGCGACGTG GCCGGCTGGG GCATAGTCAA CCACGCGGGC 
CGCCGCCCGG ACAGCCTGCA GCACGTGCTC TTGCCAGTGC TGGACCGCGC CACCTGCAAC 
CGGCGCACGC ACCACGACGG CGCCATCACC GAGCGCTTGA TGTGCGCGGA GAGCAATCGC 
CGGGACAGCT GCAAGGGTGA CTCCGGGGGC CCGCTGGTGT GCGGGGGCGT GCTCGAGGGC 
GTGGTCACCT CGGGCTCGCG CGTTTGCGGC AACCGCAAGA AGCCCGGGAT CTACACCCGC 
GTGGCGAGCT ATGCGGCCTG GATCGACAGC GTCCTGGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

CFD ( NM_001928.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001919.2 Homo sapiens complement factor D (CFD), transcript variant 1, mRNA.

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CloneID	OHu18206
Clone ID Related Accession (Same CDS sequence)	NM_001928.2 , NM_001928.3 , NM_001928.4
Accession Version	NM_001928.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 762bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	complement factor D isoform 1 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from HY087483.1, BC057807.1, HY281047.1, M84526.1 and AC112706.2. On May 17, 2019 this sequence version replaced NM_001928.3. Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AK300963.1, DRR138524.963562.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1966682, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000327726.11/ ENSP00000332139.4 RefSeq Select criteria :: based on conservation, expression ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGCACAGCT GGGAGCGCCT GGCAGTTCTG GTCCTCCTAG GAGCGGCCGC CTGCGCGGCG 
CCGCCCCGTG GTCGGATCCT GGGCGGCAGA GAGGCCGAGG CGCACGCGCG GCCCTACATG 
GCGTCGGTGC AGCTGAACGG CGCGCACCTG TGCGGCGGCG TCCTGGTGGC GGAGCAGTGG 
GTGCTGAGCG CGGCGCACTG CCTGGAGGAC GCGGCCGACG GGAAGGTGCA GGTTCTCCTG 
GGCGCGCACT CCCTGTCGCA GCCGGAGCCC TCCAAGCGCC TGTACGACGT GCTCCGCGCA 
GTGCCCCACC CGGACAGCCA GCCCGACACC ATCGACCACG ACCTCCTGCT GCTACAGCTG 
TCGGAGAAGG CCACACTGGG CCCTGCTGTG CGCCCCCTGC CCTGGCAGCG CGTGGACCGC 
GACGTGGCAC CGGGAACTCT CTGCGACGTG GCCGGCTGGG GCATAGTCAA CCACGCGGGC 
CGCCGCCCGG ACAGCCTGCA GCACGTGCTC TTGCCAGTGC TGGACCGCGC CACCTGCAAC 
CGGCGCACGC ACCACGACGG CGCCATCACC GAGCGCTTGA TGTGCGCGGA GAGCAATCGC 
CGGGACAGCT GCAAGGGTGA CTCCGGGGGC CCGCTGGTGT GCGGGGGCGT GCTCGAGGGC 
GTGGTCACCT CGGGCTCGCG CGTTTGCGGC AACCGCAAGA AGCCCGGGAT CTACACCCGC 
GTGGCGAGCT ATGCGGCCTG GATCGACAGC GTCCTGGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001919.2
CDS	27..788
Translation	MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA

Target ORF information:

RefSeq Version	NM_001928.4
Organism	Homo sapiens(human)
Definition	Homo sapiens complement factor D (CFD), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001928.4

ORF Insert Sequence:

ATGCACAGCT GGGAGCGCCT GGCAGTTCTG GTCCTCCTAG GAGCGGCCGC CTGCGCGGCG 
CCGCCCCGTG GTCGGATCCT GGGCGGCAGA GAGGCCGAGG CGCACGCGCG GCCCTACATG 
GCGTCGGTGC AGCTGAACGG CGCGCACCTG TGCGGCGGCG TCCTGGTGGC GGAGCAGTGG 
GTGCTGAGCG CGGCGCACTG CCTGGAGGAC GCGGCCGACG GGAAGGTGCA GGTTCTCCTG 
GGCGCGCACT CCCTGTCGCA GCCGGAGCCC TCCAAGCGCC TGTACGACGT GCTCCGCGCA 
GTGCCCCACC CGGACAGCCA GCCCGACACC ATCGACCACG ACCTCCTGCT GCTACAGCTG 
TCGGAGAAGG CCACACTGGG CCCTGCTGTG CGCCCCCTGC CCTGGCAGCG CGTGGACCGC 
GACGTGGCAC CGGGAACTCT CTGCGACGTG GCCGGCTGGG GCATAGTCAA CCACGCGGGC 
CGCCGCCCGG ACAGCCTGCA GCACGTGCTC TTGCCAGTGC TGGACCGCGC CACCTGCAAC 
CGGCGCACGC ACCACGACGG CGCCATCACC GAGCGCTTGA TGTGCGCGGA GAGCAATCGC 
CGGGACAGCT GCAAGGGTGA CTCCGGGGGC CCGCTGGTGT GCGGGGGCGT GCTCGAGGGC 
GTGGTCACCT CGGGCTCGCG CGTTTGCGGC AACCGCAAGA AGCCCGGGAT CTACACCCGC 
GTGGCGAGCT ATGCGGCCTG GATCGACAGC GTCCTGGCCT AG

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Associations between Th17-related inflammatory cytokines and asthma in adults: A Case-Control Study.
Scientific reports7(1)15502(2017 Nov)
Zhou T,Huang X,Zhou Y,Ma J,Zhou M,Liu Y,Xiao L,Yuan J,Xie J,Chen W

The role of production of adipsin and leptin in the development of insulin resistance in patients with abdominal obesity.
Doklady. Biochemistry and biophysics475(1)271-276(2017 Jul)
Vasilenko MA,Kirienkova EV,Skuratovskaia DA,Zatolokin PA,Mironyuk NI,Litvinova LS

Thiazolidinediones abrogate cervical cancer growth.
Experimental cell research353(2)63-71(2017 04)
Wuertz BR,Darrah L,Wudel J,Ondrey FG

Associating genetic variation at Perilipin 1, Complement Factor D and Adiponectin loci to the bone health status in North Indian population.
Gene61080-89(2017 Apr)
Sandhu HS,Puri S,Sharma R,Sokhi J,Singh G,Matharoo K,Bhanwer A

MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked.
Scientific reports631877(2016 Aug)
Dob? J,Szak?cs D,Oroszl?n G,Kortvely E,Kiss B,Boros E,Sz?sz R,Z?vodszky P,G?l P,P?l G

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CFD cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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