DEFA6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFA6
Entrez Gene ID	1671
Full Name	defensin alpha 6
Synonyms	DEF6,HD-6
General protein information	Preferred Names defensin alpha 6 Names defensin-6 defensin, alpha 6, Paneth cell-specific
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p23.1
Summary	Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes appear to be clustered on chromosome 8. The protein encoded by this gene, defensin, alpha 6, is highly expressed in the secretory granules of Paneth cells of the small intestine, and likely plays a role in host defense of human bowel. [provided by RefSeq, Oct 2014].
Disorder MIM:	600471

mRNA and Protein(s)

mRNA	Protein	Name
NM_001926.4	NP_001917.1	defensin-6 preproprotein
NM_001926.3	NP_001917.1	defensin-6 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	DEFA6	NP_001917.1
	DEFA6	XP_001098733.1

Gene Ontology
Bibliography

Related articles in PubMed

Human ?-Defensin 6 Self-Assembly Prevents Adhesion and Suppresses Virulence Traits of Candida albicans.
Chairatana P, Chiang IL, Nolan EM
Biochemistry56(8)1033-1041(2017 02)

Disentangling Nanonets: Human ?-Defensin 6 Targets Candida albicans Virulence.
Cegelski L
Biochemistry56(8)1027-1028(2017 02)

Reduced Human ?-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease.
Hayashi R, Tsuchiya K, Fukushima K, Horita N, Hibiya S, Kitagaki K, Negi M, Itoh E, Akashi T, Eishi Y, Okada E, Araki A, Ohtsuka K, Fukuda S, Ohno H, Okamoto R, Nakamura T, Tanaka S, Chayama K, Watanabe M
Inflammatory bowel diseases22(5)1119-28(2016 May)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

alpha-Defensin 6 Self-Assembly Prevents Adhesion and Suppresses Virulence Traits of Candida albicans
Title: Human ?-Defensin 6 Self-Assembly Prevents Adhesion and Suppresses Virulence Traits of Candida albicans.

HD6 assembled into nanonets can prevent key steps in C. albicans pathogenesis
Title: Disentangling Nanonets: Human ?-Defensin 6 Targets Candida albicans Virulence.

Downregulation of HD6 in noninflamed mucosa may contribute to mucosal barrier dysfunction of patients with Crohn's Disease.
Title: Reduced Human ?-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease.

Paneth cell alpha-defensin 6 is an antimicrobial peptide.
Title: Paneth cell ?-defensin 6 (HD-6) is an antimicrobial peptide.

Authors show that although NOD2 by itself can slightly up-regulate expression of HD5 and HD6, it can strongly down-regulates their expression during differentiation of the Paneth cell lineage mainly by inhibiting activation of the MAPK pathway.
Title: Regulation of human enteric ?-defensins by NOD2 in the Paneth cell lineage.

The following DEFA6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFA6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu09409	NM_001926.4 Latest version!	Homo sapiens defensin alpha 6 (DEFA6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
View Old Accession Versions >>
OHu09409	NM_001926.3	Homo sapiens defensin alpha 6 (DEFA6), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$49.50-$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFA6 ( NM_001926.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_001917.1 Homo sapiens defensin alpha 6 (DEFA6), mRNA.

Price & Availability↑

CloneID	OHu09409
Clone ID Related Accession (Same CDS sequence)	NM_001926.4 , NM_001926.3
Accession Version	NM_001926.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-26
Organism	Homo sapiens(human)
Product	defensin-6 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069667.1 and BM855691.1. On Nov 23, 2018 this sequence version replaced NM_001926.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HY306549.1, HY151424.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000297436.3/ ENSP00000297436.2 Protein has antimicrobial activity :: PMID: 22722251 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGAACCC TCACCATCCT CACTGCTGTT CTCCTCGTGG CCCTCCAGGC CAAGGCTGAG 
CCACTCCAAG CTGAGGATGA TCCACTGCAG GCAAAAGCTT ATGAGGCTGA TGCCCAGGAG 
CAGCGTGGGG CAAATGACCA GGACTTTGCC GTCTCCTTTG CAGAGGATGC AAGCTCAAGT 
CTTAGAGCTT TGGGCTCAAC AAGGGCTTTC ACTTGCCATT GCAGAAGGTC CTGTTATTCA 
ACAGAATATT CCTATGGGAC CTGCACTGTC ATGGGTATTA ACCACAGATT CTGCTGCCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001917.1
CDS	42..344
Translation	MRTLTILTAVLLVALQAKAEPLQAEDDPLQAKAYEADAQEQRGANDQDFAVSFAEDASSSLRALGSTRAFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL

Target ORF information:

RefSeq Version	NM_001926.4
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin alpha 6 (DEFA6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001926.4

ORF Insert Sequence:

ATGAGAACCC TCACCATCCT CACTGCTGTT CTCCTCGTGG CCCTCCAGGC CAAGGCTGAG 
CCACTCCAAG CTGAGGATGA TCCACTGCAG GCAAAAGCTT ATGAGGCTGA TGCCCAGGAG 
CAGCGTGGGG CAAATGACCA GGACTTTGCC GTCTCCTTTG CAGAGGATGC AAGCTCAAGT 
CTTAGAGCTT TGGGCTCAAC AAGGGCTTTC ACTTGCCATT GCAGAAGGTC CTGTTATTCA 
ACAGAATATT CCTATGGGAC CTGCACTGTC ATGGGTATTA ACCACAGATT CTGCTGCCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEFA6 ( NM_001926.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001917.1 Homo sapiens defensin alpha 6 (DEFA6), mRNA.

Price & Availability↑

CloneID	OHu09409
Clone ID Related Accession (Same CDS sequence)	NM_001926.4 , NM_001926.3
Accession Version	NM_001926.3	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 303bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-17
Organism	Homo sapiens(human)
Product	defensin-6 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC069667.1 and BM855691.1. On Dec 23, 2010 this sequence version replaced NM_001926.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: ERR279829.9706.1, HY306549.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968189, SAMEA1968540 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 22722251 ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGAACCC TCACCATCCT CACTGCTGTT CTCCTCGTGG CCCTCCAGGC CAAGGCTGAG 
CCACTCCAAG CTGAGGATGA TCCACTGCAG GCAAAAGCTT ATGAGGCTGA TGCCCAGGAG 
CAGCGTGGGG CAAATGACCA GGACTTTGCC GTCTCCTTTG CAGAGGATGC AAGCTCAAGT 
CTTAGAGCTT TGGGCTCAAC AAGGGCTTTC ACTTGCCATT GCAGAAGGTC CTGTTATTCA 
ACAGAATATT CCTATGGGAC CTGCACTGTC ATGGGTATTA ACCACAGATT CTGCTGCCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001917.1
CDS	42..344
Translation	MRTLTILTAVLLVALQAKAEPLQAEDDPLQAKAYEADAQEQRGANDQDFAVSFAEDASSSLRALGSTRAFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL

Target ORF information:

RefSeq Version	NM_001926.3
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin alpha 6 (DEFA6), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001926.3

ORF Insert Sequence:

ATGAGAACCC TCACCATCCT CACTGCTGTT CTCCTCGTGG CCCTCCAGGC CAAGGCTGAG 
CCACTCCAAG CTGAGGATGA TCCACTGCAG GCAAAAGCTT ATGAGGCTGA TGCCCAGGAG 
CAGCGTGGGG CAAATGACCA GGACTTTGCC GTCTCCTTTG CAGAGGATGC AAGCTCAAGT 
CTTAGAGCTT TGGGCTCAAC AAGGGCTTTC ACTTGCCATT GCAGAAGGTC CTGTTATTCA 
ACAGAATATT CCTATGGGAC CTGCACTGTC ATGGGTATTA ACCACAGATT CTGCTGCCTC 
TGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human ?-Defensin 6 Self-Assembly Prevents Adhesion and Suppresses Virulence Traits of Candida albicans.
Biochemistry56(8)1033-1041(2017 02)
Chairatana P,Chiang IL,Nolan EM

Disentangling Nanonets: Human ?-Defensin 6 Targets Candida albicans Virulence.
Biochemistry56(8)1027-1028(2017 02)
Cegelski L

Reduced Human ?-defensin 6 in Noninflamed Jejunal Tissue of Patients with Crohn's Disease.
Inflammatory bowel diseases22(5)1119-28(2016 May)
Hayashi R,Tsuchiya K,Fukushima K,Horita N,Hibiya S,Kitagaki K,Negi M,Itoh E,Akashi T,Eishi Y,Okada E,Araki A,Ohtsuka K,Fukuda S,Ohno H,Okamoto R,Nakamura T,Tanaka S,Chayama K,Watanabe M

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DEFA6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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