DEFA4 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DEFA4
Entrez Gene ID	1669
Full Name	defensin alpha 4
Synonyms	DEF4,HNP-4,HP-4,HP4
General protein information	Preferred Names defensin alpha 4 Names neutrophil defensin 4 corticostatin defensin, alpha 4, corticostatin defensin, alpha 4, preproprotein
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 8 Map Location: 8p23.1
Summary	Defensins are a family of antimicrobial and cytotoxic peptides thought to be involved in host defense. They are abundant in the granules of neutrophils and also found in the epithelia of mucosal surfaces such as those of the intestine, respiratory tract, urinary tract, and vagina. Members of the defensin family are highly similar in protein sequence and distinguished by a conserved cysteine motif. Several alpha defensin genes are clustered on chromosome 8. This gene differs from other genes of this family by an extra 83-base segment that is apparently the result of a recent duplication within the coding region. The protein encoded by this gene, defensin, alpha 4, is found in the neutrophils; it exhibits corticostatic activity and inhibits corticotropin stimulated corticosterone production. [provided by RefSeq, Oct 2014].
Disorder MIM:	601157

mRNA and Protein(s)

mRNA	Protein	Name
NM_001925.3	NP_001916.1	neutrophil defensin 4 preproprotein
NM_001925.2	NP_001916.1	neutrophil defensin 4 preproprotein

Pathways from BioSystems

Homologies

Homo sapiens (human)	DEFA4	NP_001916.1
Pan troglodytes (chimpanzee)	DEFA4	NP_001029078.1

Gene Ontology
Bibliography

Related articles in PubMed

Human ?-defensin (DEFA) gene expression helps to characterise benign and malignant salivary gland tumours.
Winter J, Pantelis A, Kraus D, Reckenbeil J, Reich R, Jepsen S, Fischer HP, Allam JP, Novak N, Wenghoefer M
BMC cancer12465(2012 Oct)

?-defensin 1-3 and ?-defensin 4 as predictive markers of imatinib resistance and relapse in CML patients.
Etienne G, Dupouy M, Costaglioli P, Chollet C, Lagarde V, Pasquet JM, Reiffers J, Garbay B, Mahon FX, Turcq B
Disease markers30(5)221-7(2011)

Gene expression of oncogenes, antimicrobial peptides, and cytokines in the development of oral leukoplakia.
Wenghoefer M, Pantelis A, Najafi T, Deschner J, Allam JP, Novak N, Reich R, Martini M, Berg? S, Fischer HP, Jepsen S, Winter J
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics110(3)351-6(2010 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Results indicate that the gene expression of DEFA 1/3 and 4 was significantly increased in all tumours - except for a significant decrease of DEFA 4 gene expression in pleomorphic adenomas.
Title: Human ?-defensin (DEFA) gene expression helps to characterise benign and malignant salivary gland tumours.

DEFA1-3 and DEFA4 mRNA level in peripheral blood cells can be used to identify chronic myeloid leukaemia patients who are at risk of being imatinib-resistant, before initiation of the therapy.
Title: ?-defensin 1-3 and ?-defensin 4 as predictive markers of imatinib resistance and relapse in CML patients.

The combination of an increased expression of the antimicrobial peptide DEFA-4, the oncogene S100-A7, epidermal growth factor, and tenascin-c, and a decreased Doc-1 expression in oral leukoplakia might characterize its potency of malignant transformation.
Title: Gene expression of oncogenes, antimicrobial peptides, and cytokines in the development of oral leukoplakia.

Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Polymorphisms in innate immunity genes and risk of childhood leukemia.

Observational study of gene-disease association. (HuGE Navigator)
Title: Risk of meningioma and common variation in genes related to innate immunity.

The following DEFA4 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DEFA4 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu02131	NM_001925.3 Latest version!	Homo sapiens defensin alpha 4 (DEFA4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
View Old Accession Versions >>
OHu02131	NM_001925.2	Homo sapiens defensin alpha 4 (DEFA4), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$69.30 $99.00
Hide Old Accession Versions >>

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DEFA4 ( NM_001925.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_001916.1 Homo sapiens defensin alpha 4 (DEFA4), mRNA.

Price & Availability↑

CloneID	OHu02131
Clone ID Related Accession (Same CDS sequence)	NM_001925.3 , NM_001925.2
Accession Version	NM_001925.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-03
Organism	Homo sapiens(human)
Product	neutrophil defensin 4 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU616655.1, X65977.1 and DN998607.1. On May 17, 2019 this sequence version replaced NM_001925.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HY078510.1, DN998607.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000297435.3/ ENSP00000297435.2 Protein has antimicrobial activity :: PMID: 2500436 RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGATTA TCGCCCTCCT CGCTGCTATT CTCTTGGTAG CCCTCCAGGT CCGGGCAGGC 
CCACTCCAGG CAAGAGGTGA TGAGGCTCCA GGCCAGGAGC AGCGTGGGCC AGAAGACCAG 
GACATATCTA TTTCCTTTGC ATGGGATAAA AGCTCTGCTC TTCAGGTTTC AGGCTCAACA 
AGGGGCATGG TCTGCTCTTG CAGATTAGTA TTCTGCCGGC GAACAGAACT TCGTGTTGGG 
AACTGCCTCA TTGGTGGTGT GAGTTTCACA TACTGCTGCA CGCGTGTCGA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001916.1
CDS	94..387
Translation	MRIIALLAAILLVALQVRAGPLQARGDEAPGQEQRGPEDQDISISFAWDKSSALQVSGSTRGMVCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD

Target ORF information:

RefSeq Version	NM_001925.3
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin alpha 4 (DEFA4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001925.3

ORF Insert Sequence:

ATGAGGATTA TCGCCCTCCT CGCTGCTATT CTCTTGGTAG CCCTCCAGGT CCGGGCAGGC 
CCACTCCAGG CAAGAGGTGA TGAGGCTCCA GGCCAGGAGC AGCGTGGGCC AGAAGACCAG 
GACATATCTA TTTCCTTTGC ATGGGATAAA AGCTCTGCTC TTCAGGTTTC AGGCTCAACA 
AGGGGCATGG TCTGCTCTTG CAGATTAGTA TTCTGCCGGC GAACAGAACT TCGTGTTGGG 
AACTGCCTCA TTGGTGGTGT GAGTTTCACA TACTGCTGCA CGCGTGTCGA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DEFA4 ( NM_001925.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001916.1 Homo sapiens defensin alpha 4 (DEFA4), mRNA.

Price & Availability↑

CloneID	OHu02131
Clone ID Related Accession (Same CDS sequence)	NM_001925.3 , NM_001925.2
Accession Version	NM_001925.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 294bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-23
Organism	Homo sapiens(human)
Product	neutrophil defensin 4 preproprotein
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BU616655.1, X65977.1 and DN998607.1. On Oct 10, 2014 this sequence version replaced NM_001925.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BU616655.1, X65977.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA2142853 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## Protein has antimicrobial activity :: PMID: 2500436 ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGAGGATTA TCGCCCTCCT CGCTGCTATT CTCTTGGTAG CCCTCCAGGT CCGGGCAGGC 
CCACTCCAGG CAAGAGGTGA TGAGGCTCCA GGCCAGGAGC AGCGTGGGCC AGAAGACCAG 
GACATATCTA TTTCCTTTGC ATGGGATAAA AGCTCTGCTC TTCAGGTTTC AGGCTCAACA 
AGGGGCATGG TCTGCTCTTG CAGATTAGTA TTCTGCCGGC GAACAGAACT TCGTGTTGGG 
AACTGCCTCA TTGGTGGTGT GAGTTTCACA TACTGCTGCA CGCGTGTCGA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001916.1
CDS	126..419
Translation	MRIIALLAAILLVALQVRAGPLQARGDEAPGQEQRGPEDQDISISFAWDKSSALQVSGSTRGMVCSCRLVFCRRTELRVGNCLIGGVSFTYCCTRVD

Target ORF information:

RefSeq Version	NM_001925.2
Organism	Homo sapiens(human)
Definition	Homo sapiens defensin alpha 4 (DEFA4), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001925.2

ORF Insert Sequence:

ATGAGGATTA TCGCCCTCCT CGCTGCTATT CTCTTGGTAG CCCTCCAGGT CCGGGCAGGC 
CCACTCCAGG CAAGAGGTGA TGAGGCTCCA GGCCAGGAGC AGCGTGGGCC AGAAGACCAG 
GACATATCTA TTTCCTTTGC ATGGGATAAA AGCTCTGCTC TTCAGGTTTC AGGCTCAACA 
AGGGGCATGG TCTGCTCTTG CAGATTAGTA TTCTGCCGGC GAACAGAACT TCGTGTTGGG 
AACTGCCTCA TTGGTGGTGT GAGTTTCACA TACTGCTGCA CGCGTGTCGA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Human ?-defensin (DEFA) gene expression helps to characterise benign and malignant salivary gland tumours.
BMC cancer12465(2012 Oct)
Winter J,Pantelis A,Kraus D,Reckenbeil J,Reich R,Jepsen S,Fischer HP,Allam JP,Novak N,Wenghoefer M

?-defensin 1-3 and ?-defensin 4 as predictive markers of imatinib resistance and relapse in CML patients.
Disease markers30(5)221-7(2011)
Etienne G,Dupouy M,Costaglioli P,Chollet C,Lagarde V,Pasquet JM,Reiffers J,Garbay B,Mahon FX,Turcq B

Gene expression of oncogenes, antimicrobial peptides, and cytokines in the development of oral leukoplakia.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics110(3)351-6(2010 Sep)
Wenghoefer M,Pantelis A,Najafi T,Deschner J,Allam JP,Novak N,Reich R,Martini M,Berg? S,Fischer HP,Jepsen S,Winter J

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DEFA4 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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