OXER1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	OXER1
Entrez Gene ID	165140
Full Name	oxoeicosanoid receptor 1
Synonyms	GPCR,GPR170,TG1019
General protein information	Preferred Names oxoeicosanoid receptor 1 Names oxoeicosanoid receptor 1 5-oxo-ETE G-protein coupled receptor 5-oxo-ETE acid G-protein-coupled receptor 1 G-protein coupled receptor 170 G-protein coupled receptor R527 G-protein coupled receptor TG1019 OXE receptor oxoeicosanoid (OXE) receptor 1
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 2 Map Location: 2p21

mRNA and Protein(s)

mRNA	Protein	Name
NM_148962.4	NP_683765.1	oxoeicosanoid receptor 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	OXER1	NP_683765.1
Canis lupus familiaris (dog)	OXER1	XP_005626292.1
Pan troglodytes (chimpanzee)	OXER1	XP_001139923.1
	OXER1	XP_001110986.1
Bos taurus (cattle)	OXER1	XP_005212767.1

Gene Ontology
Bibliography

Related articles in PubMed

Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer.
Kalyvianaki K, Gebhart V, Peroulis N, Panagiotopoulou C, Kiagiadaki F, Pediaditakis I, Aivaliotis M, Moustou E, Tzardi M, Notas G, Castanas E, Kampa M
Scientific reports744418(2017 Mar)

OxeR1 regulates angiotensin II and cAMP-stimulated steroid production in human H295R adrenocortical cells.
Dattilo M, Neuman I, Mu?oz M, Maloberti P, Cornejo Maciel F
Molecular and cellular endocrinology40838-44(2015 Jun)

A biased non-G?i OXE-R antagonist demonstrates that G?i protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE.
Konya V, Bl?ttermann S, Jandl K, Platzer W, Ottersbach PA, Marsche G, G?tschow M, Kostenis E, Heinemann A
Journal of immunology (Baltimore, Md. : 1950)192(10)4774-82(2014 May)

OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells.
Sarveswaran S, Ghosh J
Cancer letters336(1)185-95(2013 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

membrane receptor OxeR1 is involved in StAR protein induction and activation of steroidogenesis triggered by cAMP or angiotensin II, acting, at least in part, through ERK1/2 activation.
Title: OxeR1 regulates angiotensin II and cAMP-stimulated steroid production in human H295R adrenocortical cells.

Gue1654 as a non-Galphai-biased antagonist of OXE-R that provides a new basis for therapeutic intervention in inflammatory diseases that involve activation of eosinophils, neutrophils, and monocytes.
Title: A biased non-G?i OXE-R antagonist demonstrates that G?i protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE.

OXER1 has a role in regulating the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells
Title: OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells.

5-oxoER is critical for prostate cancer cell survival.
Title: Expression of 5-oxoETE receptor in prostate cancer cells: critical role in survival.

identification and cloning of a novel GPCR, R527; 5-oxo-ETE was identified as the ligand for R527; very high level of mRNA expression in eosinophils with high expression also detected in neutrophils and lung macrophages
Title: Expression and characterization of a 5-oxo-6E,8Z,11Z,14Z-eicosatetraenoic acid receptor highly expressed on human eosinophils and neutrophils.

The following OXER1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the OXER1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)	Select
OHu30938	NM_148962.4 Latest version!	Homo sapiens oxoeicosanoid receptor 1 (OXER1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$159.50-$223.30 $319.00

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** You may select a custom vector to replace pcDNA3.1+/C-(K)DYK after clone is added to cart.

** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

OXER1 ( NM_148962.4 ) cDNA ORF clone, Homo sapiens(human) -> NP_683765.1 Homo sapiens oxoeicosanoid receptor 1 (OXER1), mRNA.

Price & Availability↑

CloneID	OHu30938
Clone ID Related Accession (Same CDS sequence)	NM_148962.4
Accession Version	NM_148962.4 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1272bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-25
Organism	Homo sapiens(human)
Product	oxoeicosanoid receptor 1
Comment	Comment: VALIDATED REFSEQ: This record has undergone validation or preliminary review. The reference sequence was derived from BC063549.1. On Oct 13, 2006 this sequence version replaced NM_148962.3. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript is intronless :: BC063549.1 [ECO:0000345] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END##

ATGTTGTGTC ACCGTGGTGG CCAGCTGATA GTGCCAATCA TCCCACTTTG CCCTGAGCAC 
TCCTGCAGGG GTAGAAGACT CCAGAACCTT CTCTCAGGCC CATGGCCCAA GCAGCCCATG 
GAACTTCATA ACCTGAGCTC TCCATCTCCC TCTCTCTCCT CCTCTGTTCT CCCTCCCTCC 
TTCTCTCCCT CACCCTCCTC TGCTCCCTCT GCCTTTACCA CTGTGGGGGG GTCCTCTGGA 
GGGCCCTGCC ACCCCACCTC TTCCTCGCTG GTGTCTGCCT TCCTGGCACC AATCCTGGCC 
CTGGAGTTTG TCCTGGGCCT GGTGGGGAAC AGTTTGGCCC TCTTCATCTT CTGCATCCAC 
ACGCGGCCCT GGACCTCCAA CACGGTGTTC CTGGTCAGCC TGGTGGCCGC TGACTTCCTC 
CTGATCAGCA ACCTGCCCCT CCGCGTGGAC TACTACCTCC TCCATGAGAC CTGGCGCTTT 
GGGGCTGCTG CCTGCAAAGT CAACCTCTTC ATGCTGTCCA CCAACCGCAC GGCCAGCGTT 
GTCTTCCTCA CAGCCATCGC ACTCAACCGC TACCTGAAGG TGGTGCAGCC CCACCACGTG 
CTGAGCCGTG CTTCCGTGGG GGCAGCTGCC CGGGTGGCCG GGGGACTCTG GGTGGGCATC 
CTGCTCCTCA ACGGGCACCT GCTCCTGAGC ACCTTCTCCG GCCCCTCCTG CCTCAGCTAC 
AGGGTGGGCA CGAAGCCCTC GGCCTCGCTC CGCTGGCACC AGGCACTGTA CCTGCTGGAG 
TTCTTCCTGC CACTGGCGCT CATCCTCTTT GCTATTGTGA GCATTGGGCT CACCATCCGG 
AACCGTGGTC TGGGCGGGCA GGCAGGCCCG CAGAGGGCCA TGCGTGTGCT GGCCATGGTG 
GTGGCCGTCT ACACCATCTG CTTCTTGCCC AGCATCATCT TTGGCATGGC TTCCATGGTG 
GCTTTCTGGC TGTCCGCCTG CCGATCCCTG GACCTCTGCA CACAGCTCTT CCATGGCTCC 
CTGGCCTTCA CCTACCTCAA CAGTGTCCTG GACCCCGTGC TCTACTGCTT CTCTAGCCCC 
AACTTCCTCC ACCAGAGCCG GGCCTTGCTG GGCCTCACGC GGGGCCGGCA GGGCCCAGTG 
AGCGACGAGA GCTCCTACCA ACCCTCCAGG CAGTGGCGCT ACCGGGAGGC CTCTAGGAAG 
GCGGAGGCCA TAGGGAAGCT GAAAGTGCAG GGCGAGGTCT CTCTGGAAAA GGAAGGCTCC 
TCCCAGGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_683765.1
CDS	83..1354
Translation	MLCHRGGQLIVPIIPLCPEHSCRGRRLQNLLSGPWPKQPMELHNLSSPSPSLSSSVLPPSFSPSPSSAPSAFTTVGGSSGGPCHPTSSSLVSAFLAPILALEFVLGLVGNSLALFIFCIHTRPWTSNTVFLVSLVAADFLLISNLPLRVDYYLLHETWRFGAAACKVNLFMLSTNRTASVVFLTAIALNRYLKVVQPHHVLSRASVGAAARVAGGLWVGILLLNGHLLLSTFSGPSCLSYRVGTKPSASLRWHQALYLLEFFLPLALILFAIVSIGLTIRNRGLGGQAGPQRAMRVLAMVVAVYTICFLPSIIFGMASMVAFWLSACRSLDLCTQLFHGSLAFTYLNSVLDPVLYCFSSPNFLHQSRALLGLTRGRQGPVSDESSYQPSRQWRYREASRKAEAIGKLKVQGEVSLEKEGSSQG

Target ORF information:

RefSeq Version	NM_148962.4
Organism	Homo sapiens(human)
Definition	Homo sapiens oxoeicosanoid receptor 1 (OXER1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_148962.4

ORF Insert Sequence:

ATGTTGTGTC ACCGTGGTGG CCAGCTGATA GTGCCAATCA TCCCACTTTG CCCTGAGCAC 
TCCTGCAGGG GTAGAAGACT CCAGAACCTT CTCTCAGGCC CATGGCCCAA GCAGCCCATG 
GAACTTCATA ACCTGAGCTC TCCATCTCCC TCTCTCTCCT CCTCTGTTCT CCCTCCCTCC 
TTCTCTCCCT CACCCTCCTC TGCTCCCTCT GCCTTTACCA CTGTGGGGGG GTCCTCTGGA 
GGGCCCTGCC ACCCCACCTC TTCCTCGCTG GTGTCTGCCT TCCTGGCACC AATCCTGGCC 
CTGGAGTTTG TCCTGGGCCT GGTGGGGAAC AGTTTGGCCC TCTTCATCTT CTGCATCCAC 
ACGCGGCCCT GGACCTCCAA CACGGTGTTC CTGGTCAGCC TGGTGGCCGC TGACTTCCTC 
CTGATCAGCA ACCTGCCCCT CCGCGTGGAC TACTACCTCC TCCATGAGAC CTGGCGCTTT 
GGGGCTGCTG CCTGCAAAGT CAACCTCTTC ATGCTGTCCA CCAACCGCAC GGCCAGCGTT 
GTCTTCCTCA CAGCCATCGC ACTCAACCGC TACCTGAAGG TGGTGCAGCC CCACCACGTG 
CTGAGCCGTG CTTCCGTGGG GGCAGCTGCC CGGGTGGCCG GGGGACTCTG GGTGGGCATC 
CTGCTCCTCA ACGGGCACCT GCTCCTGAGC ACCTTCTCCG GCCCCTCCTG CCTCAGCTAC 
AGGGTGGGCA CGAAGCCCTC GGCCTCGCTC CGCTGGCACC AGGCACTGTA CCTGCTGGAG 
TTCTTCCTGC CACTGGCGCT CATCCTCTTT GCTATTGTGA GCATTGGGCT CACCATCCGG 
AACCGTGGTC TGGGCGGGCA GGCAGGCCCG CAGAGGGCCA TGCGTGTGCT GGCCATGGTG 
GTGGCCGTCT ACACCATCTG CTTCTTGCCC AGCATCATCT TTGGCATGGC TTCCATGGTG 
GCTTTCTGGC TGTCCGCCTG CCGATCCCTG GACCTCTGCA CACAGCTCTT CCATGGCTCC 
CTGGCCTTCA CCTACCTCAA CAGTGTCCTG GACCCCGTGC TCTACTGCTT CTCTAGCCCC 
AACTTCCTCC ACCAGAGCCG GGCCTTGCTG GGCCTCACGC GGGGCCGGCA GGGCCCAGTG 
AGCGACGAGA GCTCCTACCA ACCCTCCAGG CAGTGGCGCT ACCGGGAGGC CTCTAGGAAG 
GCGGAGGCCA TAGGGAAGCT GAAAGTGCAG GGCGAGGTCT CTCTGGAAAA GGAAGGCTCC 
TCCCAGGGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

Antagonizing effects of membrane-acting androgens on the eicosanoid receptor OXER1 in prostate cancer.
Scientific reports744418(2017 Mar)
Kalyvianaki K,Gebhart V,Peroulis N,Panagiotopoulou C,Kiagiadaki F,Pediaditakis I,Aivaliotis M,Moustou E,Tzardi M,Notas G,Castanas E,Kampa M

OxeR1 regulates angiotensin II and cAMP-stimulated steroid production in human H295R adrenocortical cells.
Molecular and cellular endocrinology40838-44(2015 Jun)
Dattilo M,Neuman I,Mu?oz M,Maloberti P,Cornejo Maciel F

A biased non-G?i OXE-R antagonist demonstrates that G?i protein subunit is not directly involved in neutrophil, eosinophil, and monocyte activation by 5-oxo-ETE.
Journal of immunology (Baltimore, Md. : 1950)192(10)4774-82(2014 May)
Konya V,Bl?ttermann S,Jandl K,Platzer W,Ottersbach PA,Marsche G,G?tschow M,Kostenis E,Heinemann A

OXER1, a G protein-coupled oxoeicosatetraenoid receptor, mediates the survival-promoting effects of arachidonate 5-lipoxygenase in prostate cancer cells.
Cancer letters336(1)185-95(2013 Aug)
Sarveswaran S,Ghosh J

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OXER1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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