AKR1C1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	AKR1C1
Entrez Gene ID	1645
Full Name	aldo-keto reductase family 1 member C1
Synonyms	2-ALPHA-HSD,20-ALPHA-HSD,C9,DD1,DD1/DD2,DDH,DDH1,H-37,HAKRC,HBAB,MBAB
General protein information	Preferred Names aldo-keto reductase family 1 member C1 Names aldo-keto reductase family 1 member C1 20 alpha-hydroxysteroid dehydrogenase aldo-keto reductase C chlordecone reductase homolog HAKRC dihydrodiol dehydrogenase 1 dihydrodiol dehydrogenase 1/2 dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase dihydrodiol dehydrogenase isoform DD1 hepatic dihydrodiol dehydrogenase high-affinity hepatic bile acid-binding protein indanol dehydrogenase trans-1,2-dihydrobenzene-1,2-diol dehydrogenase type II 3-alpha-hydroxysteroid dehydrogenase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 10 Map Location: 10p15.1
Summary	This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008].
Disorder MIM:	600449

mRNA and Protein(s)

mRNA	Protein	Name
XM_017015791.2	XP_016871280.1	aldo-keto reductase family 1 member C1 isoform X1
NM_001353.6	NP_001344.2	aldo-keto reductase family 1 member C1
NM_001353.5	NP_001344.2	aldo-keto reductase family 1 member C1
XM_017015791.1	XP_016871280.1	aldo-keto reductase family 1 member C1 isoform X1

Pathways from BioSystems

Homologies

Homo sapiens (human)	AKR1C1	NP_001344.2
Arabidopsis thaliana (thale cress)	AT1G59950	NP_176203.1
Rattus norvegicus (Norway rat)	Akr1c2	NP_001013075.1
Arabidopsis thaliana (thale cress)	AT1G59960	NP_176204.1
Homo sapiens (human)	AKR1C2	NP_995317.1
Mus musculus (house mouse)	Akr1c21	NP_084177.2
	AKR1C4	XP_001104300.1
Pan troglodytes (chimpanzee)	AKR1C1	XP_003951630.1

Gene Ontology
Bibliography

Related articles in PubMed

AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer.
Zhu H, Chang LL, Yan FJ, Hu Y, Zeng CM, Zhou TY, Yuan T, Ying MD, Cao J, He QJ, Yang B
Theranostics8(3)676-692(2018)

Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.
Shiiba M, Yamagami H, Yamamoto A, Minakawa Y, Okamoto A, Kasamatsu A, Sakamoto Y, Uzawa K, Takiguchi Y, Tanzawa H
Oncology reports37(4)2025-2032(2017 Apr)

Aldo-keto reductase 1C1 induced by interleukin-1? mediates the invasive potential and drug resistance of metastatic bladder cancer cells.
Matsumoto R, Tsuda M, Yoshida K, Tanino M, Kimura T, Nishihara H, Abe T, Shinohara N, Nonomura K, Tanaka S
Scientific reports634625(2016 Oct)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

the present study suggests that AKR1C1, AKR1C2, AKR1C3, and AKR1C4 are closely associated with drug resistance to both CDDP and 5FU, and that mefenamic acid, an inhibitor of AKR1C, restores sensitivity through inhibition of drug-resistance in human cancer cells.
Title: Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.

Data show that increased levels of AKR1C1/C2 enhanced the sensitivity of esophageal squamous cell carcinoma (ESCC) cells to ethyl-3,4-dihydroxybenzoate (EDHB).
Title: The roles of AKR1C1 and AKR1C2 in ethyl-3,4-dihydroxybenzoate induced esophageal squamous cell carcinoma cell death.

Activation of AKR1C1/ERbeta induces apoptosis by downregulation of c-FLIP in prostate cancer cells.
Title: Activation of AKR1C1/ER? induces apoptosis by downregulation of c-FLIP in prostate cancer cells: A prospective therapeutic opportunity.

results suggest a gender-specific modulatory effect of AKR1C1 on anxiety levels, most likely through changes in progesterone and allopregnanolone levels within and outside the brain
Title: Gender-specific association of variants in the AKR1C1 gene with dimensional anxiety in patients with panic disorder: additional evidence for the importance of neurosteroids in anxiety?

Studies indicate that mutations in aldo-keto reductase family 1 (AKR1) enzymes AKR1C1 and AKR1C4 are responsible for sexual development dysgenesis and mutations in AKR1D1 are causative in bile-acid deficiency.
Title: Role of aldo-keto reductase family 1 (AKR1) enzymes in human steroid metabolism.

The following AKR1C1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the AKR1C1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu31117	NM_001353.6 Latest version!	Homo sapiens aldo-keto reductase family 1 member C1 (AKR1C1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu91157	XM_017015791.2 Latest version!	Homo sapiens aldo-keto reductase family 1 member C1 (AKR1C1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
View Old Accession Versions >>
OHu31117	NM_001353.5	Homo sapiens aldo-keto reductase family 1 member C1 (AKR1C1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$99.50-$139.30 $199.00
OHu91157	XM_017015791.1	Homo sapiens aldo-keto reductase family 1, member C1 (AKR1C1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	9-11	$139.30 $199.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

AKR1C1 ( NM_001353.6 ) cDNA ORF clone, Homo sapiens(human) -> NP_001344.2 Homo sapiens aldo-keto reductase family 1 member C1 (AKR1C1), mRNA.

Price & Availability↑

CloneID	OHu31117
Clone ID Related Accession (Same CDS sequence)	NM_001353.6 , NM_001353.5
Accession Version	NM_001353.6 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-30
Organism	Homo sapiens(human)
Product	aldo-keto reductase family 1 member C1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC040210.1, CB119749.1, M86609.1 and AL713867.6. On Nov 22, 2018 this sequence version replaced NM_001353.5. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1660805.26350.1, SRR1660805.179145.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000380872.9/ ENSP00000370254.4 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGGATTCGA AATATCAGTG TGTGAAGCTG AATGATGGTC ACTTCATGCC TGTCCTGGGA 
TTTGGCACCT ATGCGCCTGC AGAGGTTCCT AAAAGTAAAG CTTTAGAGGC CACCAAATTG 
GCAATTGAAG CTGGCTTCCG CCATATTGAT TCTGCTCATT TATACAATAA TGAGGAGCAG 
GTTGGACTGG CCATCCGAAG CAAGATTGCA GATGGCAGTG TGAAGAGAGA AGACATATTC 
TACACTTCAA AGCTTTGGTG CAATTCCCAT CGACCAGAGT TGGTCCGACC AGCCTTGGAA 
AGGTCACTGA AAAATCTTCA ATTGGATTAT GTTGACCTCT ACCTTATTCA TTTTCCAGTG 
TCTGTAAAGC CAGGTGAGGA AGTGATCCCA AAAGATGAAA ATGGAAAAAT ACTATTTGAC 
ACAGTGGATC TCTGTGCCAC ATGGGAGGCC GTGGAGAAGT GTAAAGATGC AGGATTGGCC 
AAGTCCATCG GGGTGTCCAA CTTCAACCGC AGGCAGCTGG AGATGATCCT CAACAAGCCA 
GGGCTCAAGT ACAAGCCTGT CTGCAACCAG GTGGAATGTC ATCCTTACTT CAACCAGAGA 
AAACTGCTGG ATTTCTGCAA GTCAAAAGAC ATTGTTCTGG TTGCCTATAG TGCTCTGGGA 
TCCCACCGAG AAGAACCATG GGTGGACCCG AACTCCCCGG TGCTCTTGGA GGACCCAGTC 
CTTTGTGCCT TGGCAAAAAA GCACAAGCGA ACCCCAGCCC TGATTGCCCT GCGCTACCAG 
CTACAGCGTG GGGTTGTGGT CCTGGCCAAG AGCTACAATG AGCAGCGCAT CAGACAGAAC 
GTGCAGGTGT TTGAATTCCA GTTGACTTCA GAGGAGATGA AAGCCATAGA TGGCCTAAAC 
AGAAATGTGC GATATTTGAC CCTTGATATT TTTGCTGGCC CCCCTAATTA TCCATTTTCT 
GATGAATATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001344.2
CDS	31..1002
Translation	MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY

Target ORF information:

RefSeq Version	NM_001353.6
Organism	Homo sapiens(human)
Definition	Homo sapiens aldo-keto reductase family 1 member C1 (AKR1C1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001353.6

ORF Insert Sequence:

ATGGATTCGA AATATCAGTG TGTGAAGCTG AATGATGGTC ACTTCATGCC TGTCCTGGGA 
TTTGGCACCT ATGCGCCTGC AGAGGTTCCT AAAAGTAAAG CTTTAGAGGC CACCAAATTG 
GCAATTGAAG CTGGCTTCCG CCATATTGAT TCTGCTCATT TATACAATAA TGAGGAGCAG 
GTTGGACTGG CCATCCGAAG CAAGATTGCA GATGGCAGTG TGAAGAGAGA AGACATATTC 
TACACTTCAA AGCTTTGGTG CAATTCCCAT CGACCAGAGT TGGTCCGACC AGCCTTGGAA 
AGGTCACTGA AAAATCTTCA ATTGGATTAT GTTGACCTCT ACCTTATTCA TTTTCCAGTG 
TCTGTAAAGC CAGGTGAGGA AGTGATCCCA AAAGATGAAA ATGGAAAAAT ACTATTTGAC 
ACAGTGGATC TCTGTGCCAC ATGGGAGGCC GTGGAGAAGT GTAAAGATGC AGGATTGGCC 
AAGTCCATCG GGGTGTCCAA CTTCAACCGC AGGCAGCTGG AGATGATCCT CAACAAGCCA 
GGGCTCAAGT ACAAGCCTGT CTGCAACCAG GTGGAATGTC ATCCTTACTT CAACCAGAGA 
AAACTGCTGG ATTTCTGCAA GTCAAAAGAC ATTGTTCTGG TTGCCTATAG TGCTCTGGGA 
TCCCACCGAG AAGAACCATG GGTGGACCCG AACTCCCCGG TGCTCTTGGA GGACCCAGTC 
CTTTGTGCCT TGGCAAAAAA GCACAAGCGA ACCCCAGCCC TGATTGCCCT GCGCTACCAG 
CTACAGCGTG GGGTTGTGGT CCTGGCCAAG AGCTACAATG AGCAGCGCAT CAGACAGAAC 
GTGCAGGTGT TTGAATTCCA GTTGACTTCA GAGGAGATGA AAGCCATAGA TGGCCTAAAC 
AGAAATGTGC GATATTTGAC CCTTGATATT TTTGCTGGCC CCCCTAATTA TCCATTTTCT 
GATGAATATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AKR1C1 ( NM_001353.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_001344.2 Homo sapiens aldo-keto reductase family 1 member C1 (AKR1C1), mRNA.

Price & Availability↑

CloneID	OHu31117
Clone ID Related Accession (Same CDS sequence)	NM_001353.6 , NM_001353.5
Accession Version	NM_001353.5	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 972bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-12-10
Organism	Homo sapiens(human)
Product	aldo-keto reductase family 1 member C1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from BC040210.1, CB119749.1 and M86609.1. On or before Mar 29, 2008 this sequence version replaced XM_001724839.1, NM_001353.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: M86609.1, SRR1660805.43469.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1965299, SAMEA1966682 [ECO:0000348] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGGATTCGA AATATCAGTG TGTGAAGCTG AATGATGGTC ACTTCATGCC TGTCCTGGGA 
TTTGGCACCT ATGCGCCTGC AGAGGTTCCT AAAAGTAAAG CTTTAGAGGC CACCAAATTG 
GCAATTGAAG CTGGCTTCCG CCATATTGAT TCTGCTCATT TATACAATAA TGAGGAGCAG 
GTTGGACTGG CCATCCGAAG CAAGATTGCA GATGGCAGTG TGAAGAGAGA AGACATATTC 
TACACTTCAA AGCTTTGGTG CAATTCCCAT CGACCAGAGT TGGTCCGACC AGCCTTGGAA 
AGGTCACTGA AAAATCTTCA ATTGGATTAT GTTGACCTCT ACCTTATTCA TTTTCCAGTG 
TCTGTAAAGC CAGGTGAGGA AGTGATCCCA AAAGATGAAA ATGGAAAAAT ACTATTTGAC 
ACAGTGGATC TCTGTGCCAC ATGGGAGGCC GTGGAGAAGT GTAAAGATGC AGGATTGGCC 
AAGTCCATCG GGGTGTCCAA CTTCAACCGC AGGCAGCTGG AGATGATCCT CAACAAGCCA 
GGGCTCAAGT ACAAGCCTGT CTGCAACCAG GTGGAATGTC ATCCTTACTT CAACCAGAGA 
AAACTGCTGG ATTTCTGCAA GTCAAAAGAC ATTGTTCTGG TTGCCTATAG TGCTCTGGGA 
TCCCACCGAG AAGAACCATG GGTGGACCCG AACTCCCCGG TGCTCTTGGA GGACCCAGTC 
CTTTGTGCCT TGGCAAAAAA GCACAAGCGA ACCCCAGCCC TGATTGCCCT GCGCTACCAG 
CTACAGCGTG GGGTTGTGGT CCTGGCCAAG AGCTACAATG AGCAGCGCAT CAGACAGAAC 
GTGCAGGTGT TTGAATTCCA GTTGACTTCA GAGGAGATGA AAGCCATAGA TGGCCTAAAC 
AGAAATGTGC GATATTTGAC CCTTGATATT TTTGCTGGCC CCCCTAATTA TCCATTTTCT 
GATGAATATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001344.2
CDS	184..1155
Translation	MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY

Target ORF information:

RefSeq Version	NM_001353.5
Organism	Homo sapiens(human)
Definition	Homo sapiens aldo-keto reductase family 1 member C1 (AKR1C1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001353.5

ORF Insert Sequence:

ATGGATTCGA AATATCAGTG TGTGAAGCTG AATGATGGTC ACTTCATGCC TGTCCTGGGA 
TTTGGCACCT ATGCGCCTGC AGAGGTTCCT AAAAGTAAAG CTTTAGAGGC CACCAAATTG 
GCAATTGAAG CTGGCTTCCG CCATATTGAT TCTGCTCATT TATACAATAA TGAGGAGCAG 
GTTGGACTGG CCATCCGAAG CAAGATTGCA GATGGCAGTG TGAAGAGAGA AGACATATTC 
TACACTTCAA AGCTTTGGTG CAATTCCCAT CGACCAGAGT TGGTCCGACC AGCCTTGGAA 
AGGTCACTGA AAAATCTTCA ATTGGATTAT GTTGACCTCT ACCTTATTCA TTTTCCAGTG 
TCTGTAAAGC CAGGTGAGGA AGTGATCCCA AAAGATGAAA ATGGAAAAAT ACTATTTGAC 
ACAGTGGATC TCTGTGCCAC ATGGGAGGCC GTGGAGAAGT GTAAAGATGC AGGATTGGCC 
AAGTCCATCG GGGTGTCCAA CTTCAACCGC AGGCAGCTGG AGATGATCCT CAACAAGCCA 
GGGCTCAAGT ACAAGCCTGT CTGCAACCAG GTGGAATGTC ATCCTTACTT CAACCAGAGA 
AAACTGCTGG ATTTCTGCAA GTCAAAAGAC ATTGTTCTGG TTGCCTATAG TGCTCTGGGA 
TCCCACCGAG AAGAACCATG GGTGGACCCG AACTCCCCGG TGCTCTTGGA GGACCCAGTC 
CTTTGTGCCT TGGCAAAAAA GCACAAGCGA ACCCCAGCCC TGATTGCCCT GCGCTACCAG 
CTACAGCGTG GGGTTGTGGT CCTGGCCAAG AGCTACAATG AGCAGCGCAT CAGACAGAAC 
GTGCAGGTGT TTGAATTCCA GTTGACTTCA GAGGAGATGA AAGCCATAGA TGGCCTAAAC 
AGAAATGTGC GATATTTGAC CCTTGATATT TTTGCTGGCC CCCCTAATTA TCCATTTTCT 
GATGAATATT AA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AKR1C1 ( XM_017015791.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_016871280.1 Homo sapiens aldo-keto reductase family 1 member C1 (AKR1C1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu91157
Clone ID Related Accession (Same CDS sequence)	XM_017015791.2 , XM_017015791.1
Accession Version	XM_017015791.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	aldo-keto reductase family 1 member C1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Mar 26, 2018 this sequence version replaced XM_017015791.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATTCGA AATATCAGTG TGTGAAGCTG AATGATGGTC ACTTCATGCC TGTCCTGGGA 
TTTGGCACCT ATGCGCCTGC AGAGGTTCCT AAAAGTAAAG CTTTAGAGGC CACCAAATTG 
GCAATTGAAG CTGGCTTCCG CCATATTGAT TCTGCTCATT TATACAATAA TGAGGAGCAG 
GTTGGACTGG CCATCCGAAG CAAGATTGCA GATGGCAGTG TGAAGAGAGA AGACATATTC 
TACACTTCAA AGCTTTGGTG CAATTCCCAT CGACCAGAGT TGGTCCGACC AGCCTTGGAA 
AGGTCACTGA AAAATCTTCA ATTGGATTAT GTTGACCTCT ACCTTATTCA TTTTCCAGTG 
TCTGTAAAGG CCGTGGAGAA GTGTAAAGAT GCAGGATTGG CCAAGTCCAT CGGGGTGTCC 
AACTTCAACC GCAGGCAGCT GGAGATGATC CTCAACAAGC CAGGGCTCAA GTACAAGCCT 
GTCTGCAACC AGGTGGAATG TCATCCTTAC TTCAACCAGA GAAAACTGCT GGATTTCTGC 
AAGTCAAAAG ACATTGTTCT GGTTGCCTAT AGTGCTCTGG GATCCCACCG AGAAGAACCA 
TGGGTGGACC CGAACTCCCC GGTGCTCTTG GAGGACCCAG TCCTTTGTGC CTTGGCAAAA 
AAGCACAAGC GAACCCCAGC CCTGATTGCC CTGCGCTACC AGCTACAGCG TGGGGTTGTG 
GTCCTGGCCA AGAGCTACAA TGAGCAGCGC ATCAGACAGA ACGTGCAGGT GTTTGAATTC 
CAGTTGACTT CAGAGGAGAT GAAAGCCATA GATGGCCTAA ACAGAAATGT GCGATATTTG 
ACCCTTGATA TTTTTGCTGG CCCCCCTAAT TATCCATTTT CTGATGAATA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016871280.1
CDS	31..924
Translation	MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY

Target ORF information:

RefSeq Version	XM_017015791.2
Organism	Homo sapiens(human)
Definition	Homo sapiens aldo-keto reductase family 1 member C1 (AKR1C1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017015791.2

ORF Insert Sequence:

ATGGATTCGA AATATCAGTG TGTGAAGCTG AATGATGGTC ACTTCATGCC TGTCCTGGGA 
TTTGGCACCT ATGCGCCTGC AGAGGTTCCT AAAAGTAAAG CTTTAGAGGC CACCAAATTG 
GCAATTGAAG CTGGCTTCCG CCATATTGAT TCTGCTCATT TATACAATAA TGAGGAGCAG 
GTTGGACTGG CCATCCGAAG CAAGATTGCA GATGGCAGTG TGAAGAGAGA AGACATATTC 
TACACTTCAA AGCTTTGGTG CAATTCCCAT CGACCAGAGT TGGTCCGACC AGCCTTGGAA 
AGGTCACTGA AAAATCTTCA ATTGGATTAT GTTGACCTCT ACCTTATTCA TTTTCCAGTG 
TCTGTAAAGG CCGTGGAGAA GTGTAAAGAT GCAGGATTGG CCAAGTCCAT CGGGGTGTCC 
AACTTCAACC GCAGGCAGCT GGAGATGATC CTCAACAAGC CAGGGCTCAA GTACAAGCCT 
GTCTGCAACC AGGTGGAATG TCATCCTTAC TTCAACCAGA GAAAACTGCT GGATTTCTGC 
AAGTCAAAAG ACATTGTTCT GGTTGCCTAT AGTGCTCTGG GATCCCACCG AGAAGAACCA 
TGGGTGGACC CGAACTCCCC GGTGCTCTTG GAGGACCCAG TCCTTTGTGC CTTGGCAAAA 
AAGCACAAGC GAACCCCAGC CCTGATTGCC CTGCGCTACC AGCTACAGCG TGGGGTTGTG 
GTCCTGGCCA AGAGCTACAA TGAGCAGCGC ATCAGACAGA ACGTGCAGGT GTTTGAATTC 
CAGTTGACTT CAGAGGAGAT GAAAGCCATA GATGGCCTAA ACAGAAATGT GCGATATTTG 
ACCCTTGATA TTTTTGCTGG CCCCCCTAAT TATCCATTTT CTGATGAATA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

AKR1C1 ( XM_017015791.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016871280.1 Homo sapiens aldo-keto reductase family 1, member C1 (AKR1C1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu91157
Clone ID Related Accession (Same CDS sequence)	XM_017015791.2 , XM_017015791.1
Accession Version	XM_017015791.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 894bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2016-06-05
Organism	Homo sapiens(human)
Product	aldo-keto reductase family 1 member C1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000010.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Full annotation Annotation Version :: Homo sapiens Annotation Release 108 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 7.0 Annotation Method :: Best-placed RefSeq; Gnomon Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATTCGA AATATCAGTG TGTGAAGCTG AATGATGGTC ACTTCATGCC TGTCCTGGGA 
TTTGGCACCT ATGCGCCTGC AGAGGTTCCT AAAAGTAAAG CTTTAGAGGC CACCAAATTG 
GCAATTGAAG CTGGCTTCCG CCATATTGAT TCTGCTCATT TATACAATAA TGAGGAGCAG 
GTTGGACTGG CCATCCGAAG CAAGATTGCA GATGGCAGTG TGAAGAGAGA AGACATATTC 
TACACTTCAA AGCTTTGGTG CAATTCCCAT CGACCAGAGT TGGTCCGACC AGCCTTGGAA 
AGGTCACTGA AAAATCTTCA ATTGGATTAT GTTGACCTCT ACCTTATTCA TTTTCCAGTG 
TCTGTAAAGG CCGTGGAGAA GTGTAAAGAT GCAGGATTGG CCAAGTCCAT CGGGGTGTCC 
AACTTCAACC GCAGGCAGCT GGAGATGATC CTCAACAAGC CAGGGCTCAA GTACAAGCCT 
GTCTGCAACC AGGTGGAATG TCATCCTTAC TTCAACCAGA GAAAACTGCT GGATTTCTGC 
AAGTCAAAAG ACATTGTTCT GGTTGCCTAT AGTGCTCTGG GATCCCACCG AGAAGAACCA 
TGGGTGGACC CGAACTCCCC GGTGCTCTTG GAGGACCCAG TCCTTTGTGC CTTGGCAAAA 
AAGCACAAGC GAACCCCAGC CCTGATTGCC CTGCGCTACC AGCTACAGCG TGGGGTTGTG 
GTCCTGGCCA AGAGCTACAA TGAGCAGCGC ATCAGACAGA ACGTGCAGGT GTTTGAATTC 
CAGTTGACTT CAGAGGAGAT GAAAGCCATA GATGGCCTAA ACAGAAATGT GCGATATTTG 
ACCCTTGATA TTTTTGCTGG CCCCCCTAAT TATCCATTTT CTGATGAATA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016871280.1
CDS	54..947
Translation	MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEATKLAIEAGFRHIDSAHLYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWCNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKAVEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY

Target ORF information:

RefSeq Version	XM_017015791.1
Organism	Homo sapiens(human)
Definition	Homo sapiens aldo-keto reductase family 1, member C1 (AKR1C1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017015791.1

ORF Insert Sequence:

ATGGATTCGA AATATCAGTG TGTGAAGCTG AATGATGGTC ACTTCATGCC TGTCCTGGGA 
TTTGGCACCT ATGCGCCTGC AGAGGTTCCT AAAAGTAAAG CTTTAGAGGC CACCAAATTG 
GCAATTGAAG CTGGCTTCCG CCATATTGAT TCTGCTCATT TATACAATAA TGAGGAGCAG 
GTTGGACTGG CCATCCGAAG CAAGATTGCA GATGGCAGTG TGAAGAGAGA AGACATATTC 
TACACTTCAA AGCTTTGGTG CAATTCCCAT CGACCAGAGT TGGTCCGACC AGCCTTGGAA 
AGGTCACTGA AAAATCTTCA ATTGGATTAT GTTGACCTCT ACCTTATTCA TTTTCCAGTG 
TCTGTAAAGG CCGTGGAGAA GTGTAAAGAT GCAGGATTGG CCAAGTCCAT CGGGGTGTCC 
AACTTCAACC GCAGGCAGCT GGAGATGATC CTCAACAAGC CAGGGCTCAA GTACAAGCCT 
GTCTGCAACC AGGTGGAATG TCATCCTTAC TTCAACCAGA GAAAACTGCT GGATTTCTGC 
AAGTCAAAAG ACATTGTTCT GGTTGCCTAT AGTGCTCTGG GATCCCACCG AGAAGAACCA 
TGGGTGGACC CGAACTCCCC GGTGCTCTTG GAGGACCCAG TCCTTTGTGC CTTGGCAAAA 
AAGCACAAGC GAACCCCAGC CCTGATTGCC CTGCGCTACC AGCTACAGCG TGGGGTTGTG 
GTCCTGGCCA AGAGCTACAA TGAGCAGCGC ATCAGACAGA ACGTGCAGGT GTTTGAATTC 
CAGTTGACTT CAGAGGAGAT GAAAGCCATA GATGGCCTAA ACAGAAATGT GCGATATTTG 
ACCCTTGATA TTTTTGCTGG CCCCCCTAAT TATCCATTTT CTGATGAATA TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

AKR1C1 Activates STAT3 to Promote the Metastasis of Non-Small Cell Lung Cancer.
Theranostics8(3)676-692(2018)
Zhu H,Chang LL,Yan FJ,Hu Y,Zeng CM,Zhou TY,Yuan T,Ying MD,Cao J,He QJ,Yang B

Mefenamic acid enhances anticancer drug sensitivity via inhibition of aldo-keto reductase 1C enzyme activity.
Oncology reports37(4)2025-2032(2017 Apr)
Shiiba M,Yamagami H,Yamamoto A,Minakawa Y,Okamoto A,Kasamatsu A,Sakamoto Y,Uzawa K,Takiguchi Y,Tanzawa H

Aldo-keto reductase 1C1 induced by interleukin-1? mediates the invasive potential and drug resistance of metastatic bladder cancer cells.
Scientific reports634625(2016 Oct)
Matsumoto R,Tsuda M,Yoshida K,Tanino M,Kimura T,Nishihara H,Abe T,Shinohara N,Nonomura K,Tanaka S

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AKR1C1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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