SASS6 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	SASS6
Entrez Gene ID	163786
Full Name	SAS-6 centriolar assembly protein
Synonyms	MCPH14,SAS-6,SAS6
General protein information	Preferred Names SAS-6 centriolar assembly protein Names spindle assembly abnormal protein 6 homolog
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 1 Map Location: 1p21.2
Summary	The protein encoded by this gene is a central component of centrioles and is necessary for their duplication and function. Centrioles adopt a cartwheel-shaped structure, with the encoded protein forming the hub and spokes inside a microtubule cylinder. Defects in this gene are a cause of autosomal recessive primary microcephaly. [provided by RefSeq, Oct 2016].
Disorder MIM:	609321
Disorder Html:	?Microcephaly 14, primary, autosomal recessive, 616402 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_001304829.2	NP_001291758.1	spindle assembly abnormal protein 6 homolog isoform 2
XM_017000486.1	XP_016855975.1	spindle assembly abnormal protein 6 homolog isoform X1
NM_194292.3	NP_919268.1	spindle assembly abnormal protein 6 homolog isoform 1
NM_194292.2	NP_919268.1	spindle assembly abnormal protein 6 homolog isoform 1
NM_001304829.1	NP_001291758.1	spindle assembly abnormal protein 6 homolog isoform 2

Pathways from BioSystems

Homologies

Bos taurus (cattle)	SASS6	NP_001178955.1
Xenopus tropicalis (tropical clawed frog)	sass6	NP_001039141.1
Homo sapiens (human)	SASS6	NP_919268.1
Pan troglodytes (chimpanzee)	SASS6	XP_513588.2
Mus musculus (house mouse)	Sass6	NP_082625.2
Danio rerio (zebrafish)	sass6	NP_998603.1
	SASS6	XP_001106791.2
Canis lupus familiaris (dog)	SASS6	XP_547263.4
Rattus norvegicus (Norway rat)	Sass6	NP_001101189.1
Gallus gallus (chicken)	SASS6	NP_001026444.1

Gene Ontology
Bibliography

Related articles in PubMed

The PLK4-STIL-SAS-6 module at the core of centriole duplication.
Arquint C, Nigg EA
Biochemical Society transactions44(5)1253-1263(2016 10)

SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Hilbert M, Noga A, Frey D, Hamel V, Guichard P, Kraatz SH, Pfreundschuh M, Hosner S, Fl?ckiger I, Jaussi R, Wieser MM, Thieltges KM, Deupi X, M?ller DJ, Kammerer RA, G?nczy P, Hirono M, Steinmetz MO
Nature cell biology18(4)393-403(2016 Apr)

Human SAS-6 C-Terminus Nucleates and Promotes Microtubule Assembly in Vitro by Binding to Microtubules.
Gupta H, Badarudeen B, George A, Thomas GE, Gireesh KK, Manna TK
Biochemistry54(41)6413-22(2015 Oct)

SASS6 overexpression is associated with mitotic chromosomal abnormalities and a poor prognosis in patients with colorectal cancer.
Shinmura K, Kato H, Kawanishi Y, Nagura K, Kamo T, Okubo Y, Inoue Y, Kurabe N, Du C, Iwaizumi M, Kurachi K, Nakamura T, Sugimura H
Oncology reports34(2)727-38(2015 Aug)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Studies indicate that depletion of any one of the protein kinase polo-like kinase 4 (PLK4) and the two proteins STIL and SAS-6 blocks centriole duplication, and, conversely, overexpression causes centriole amplification.
Title: The PLK4-STIL-SAS-6 module at the core of centriole duplication.

expression of wild-type centriolar assembly protein SAS-6 in a SAS-6-depleted background resulted in centriole sizes that are similar to wild type.
Title: SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.

SAS6 possesses an intrinsic microtubule assembly promoting activity and its outer exposed C-terminal tail may play critical roles in microtubule assembly and stabilizing microtubule attachment with the centriolar cartwheel.
Title: Human SAS-6 C-Terminus Nucleates and Promotes Microtubule Assembly in Vitro by Binding to Microtubules.

Our present findings revealed that the upregulation of SASS6 expression is involved in the pathogenesis of CRC and is associated with a poor prognosis among patients with colon cancer.
Title: SASS6 overexpression is associated with mitotic chromosomal abnormalities and a poor prognosis in patients with colorectal cancer.

A homozygous c.185T>C missense mutation in the HsSAS-6 gene is associated with the cause of autosomal recessive primary microcephaly.
Title: A missense mutation in the PISA domain of HsSAS-6 causes autosomal recessive primary microcephaly in a large consanguineous Pakistani family.

The following SASS6 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the SASS6 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu24071	NM_194292.3 Latest version!	Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
OHu77228	NM_001304829.2 Latest version!	Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
OHu83246	XM_017000486.1 Latest version!	Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	10-12	$307.30 $439.00
View Old Accession Versions >>
OHu24071	NM_194292.2	Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant 1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	in pcDNA3.1-C-(k)DYK	$274.50-$384.30 $549.00
OHu77228	NM_001304829.1	Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant 2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	7-9	$223.30 $319.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

SASS6 ( NM_194292.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_919268.1 Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24071
Clone ID Related Accession (Same CDS sequence)	NM_194292.3 , NM_194292.2
Accession Version	NM_194292.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1974bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-08-21
Organism	Homo sapiens(human)
Product	spindle assembly abnormal protein 6 homolog isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY359522.1. This sequence is a reference standard in the RefSeqGene project. On Nov 23, 2018 this sequence version replaced NM_194292.2. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY359522.1, BX648406.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## MANE Ensembl match :: ENST00000287482.6/ ENSP00000287482.5 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: full length.

ATGAGCCAAG TGCTGTTCCA CCAACTAGTC CCGTTGCAGG TGAAATGCAA AGACTGTGAG 
GAGAGGAGAG TAAGTATAAG AATGAGCATT GAACTACAAT CAGTTTCTAA TCCAGTTCAC 
AGAAAGGACT TAGTTATTCG TCTGACTGAT GACACGGATC CATTTTTTTT ATATAACCTT 
GTTATATCTG AGGAAGATTT TCAAAGTTTA AAATTCCAGC AAGGTCTTCT GGTAGACTTC 
TTAGCTTTCC CACAAAAATT TATAGATCTC CTTCAGCAAT GTACTCAAGA ACATGCCAAA 
GAAATTCCAA GGTTTTTGCT ACAGTTAGTT TCTCCAGCAG CTATTTTGGA TAACTCACCT 
GCATTTTTAA ATGTGGTAGA GACAAATCCT TTTAAGCATC TTACACACCT CTCACTAAAA 
CTTTTACCTG GAAATGATGT GGAGATAAAG AAATTTCTCG CAGGCTGTTT GAAATGTAGC 
AAGGAAGAAA AATTATCATT GATGCAATCA CTAGATGATG CTACTAAGCA ACTGGACTTT 
ACACGAAAGA CATTAGCAGA AAAAAAACAA GAATTAGATA AGTTACGGAA TGAATGGGCG 
TCACATACAG CAGCCTTGAC AAACAAGCAT TCTCAGGAAC TGACAAATGA AAAGGAAAAA 
GCCTTGCAGG CACAGGTTCA ATATCAACAG CAGCATGAAC AACAGAAAAA AGATTTAGAA 
ATCCTCCATC AACAAAACAT CCACCAGCTA CAAAACAGAC TGTCTGAGTT AGAAGCGGCT 
AATAAAGACT TAACCGAAAG AAAATATAAA GGAGACTCCA CTATTAGAGA ACTTAAAGCA 
AAACTTTCTG GTGTTGAAGA GGAGCTACAG CGGACTAAGC AAGAAGTCCT CTCTTTGCGA 
AGAGAGAATT CTACACTAGA TGTTGAATGC CACGAGAAAG AAAAGCACGT TAATCAGCTA 
CAAACAAAAG TGGCAGTTTT AGAACAGGAA ATCAAGGATA AGGACCAGCT TGTTTTAAGA 
ACAAAAGAGG CATTTGATAC AATCCAGGAA CAAAAGGTGG TTTTAGAAGA AAATGGTGAG 
AAAAATCAAG TACAACTAGG AAAGCTTGAA GCTACAATAA AATCATTATC TGCAGAACTT 
CTGAAGGCAA ATGAAATTAT CAAGAAGTTA CAAGGGGATC TGAAAACTTT AATGGGTAAG 
TTGAAATTGA AGAATACAGT TACTATTCAG CAAGAAAAAC TCTTGGCTGA GAAGGAGGAA 
AAATTACAAA AGGAACAAAA GGAATTACAA GATGTTGGAC AGTCTCTTCG AATTAAAGAG 
CAAGAGGTAT GCAAATTACA AGAACAATTA GAAGCTACAG TTAAAAAACT TGAAGAAAGC 
AAACAACTTC TAAAAAATAA TGAAAAGTTA ATCACGTGGT TAAATAAAGA ACTAAATGAA 
AATCAGCTAG TGAGAAAGCA AGATGTATTG GGACCTTCTA CTACTCCGCC TGCACATTCC 
AGCAGCAACA CAATCAGAAG TGGAATTTCT CCTAACCTGA ATGTGGTTGA TGGTAGACTG 
ACTTACCCAA CCTGTGGGAT TGGTTATCCT GTCTCCTCTG CATTTGCATT CCAGAATACC 
TTCCCTCATT CGATATCTGC CAAAAATACC AGCCACCCTG GTTCAGGAAC AAAGGTTCAG 
TTTAATTTGC AGTTTACAAA ACCAAATGCA TCACTAGGAG ATGTTCAGTC AGGAGCAACT 
ATTAGTATGC CTTGCTCAAC TGATAAGGAA AATGGTGAAA ATGTAGGGTT GGAATCCAAA 
TACCTGAAGA AAAGGGAAGA TAGCATTCCT TTACGCGGAC TCAGCCAGAA CCTATTTAGT 
AATTCAGACC ATCAGAGAGA TGGCACTTTA GGAGCATTAC ATACATCTTC CAAACCCACA 
GCGCTCCCCT CTGCGTCTTC AGCCTATTTC CCTGGGCAGT TACCAAACAG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_919268.1
CDS	117..2090
Translation	MSQVLFHQLVPLQVKCKDCEERRVSIRMSIELQSVSNPVHRKDLVIRLTDDTDPFFLYNLVISEEDFQSLKFQQGLLVDFLAFPQKFIDLLQQCTQEHAKEIPRFLLQLVSPAAILDNSPAFLNVVETNPFKHLTHLSLKLLPGNDVEIKKFLAGCLKCSKEEKLSLMQSLDDATKQLDFTRKTLAEKKQELDKLRNEWASHTAALTNKHSQELTNEKEKALQAQVQYQQQHEQQKKDLEILHQQNIHQLQNRLSELEAANKDLTERKYKGDSTIRELKAKLSGVEEELQRTKQEVLSLRRENSTLDVECHEKEKHVNQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVVLEENGEKNQVQLGKLEATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEKLQKEQKELQDVGQSLRIKEQEVCKLQEQLEATVKKLEESKQLLKNNEKLITWLNKELNENQLVRKQDVLGPSTTPPAHSSSNTIRSGISPNLNVVDGRLTYPTCGIGYPVSSAFAFQNTFPHSISAKNTSHPGSGTKVQFNLQFTKPNASLGDVQSGATISMPCSTDKENGENVGLESKYLKKREDSIPLRGLSQNLFSNSDHQRDGTLGALHTSSKPTALPSASSAYFPGQLPNS

Target ORF information:

RefSeq Version	NM_194292.3
Organism	Homo sapiens(human)
Definition	Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_194292.3

ORF Insert Sequence:

ATGAGCCAAG TGCTGTTCCA CCAACTAGTC CCGTTGCAGG TGAAATGCAA AGACTGTGAG 
GAGAGGAGAG TAAGTATAAG AATGAGCATT GAACTACAAT CAGTTTCTAA TCCAGTTCAC 
AGAAAGGACT TAGTTATTCG TCTGACTGAT GACACGGATC CATTTTTTTT ATATAACCTT 
GTTATATCTG AGGAAGATTT TCAAAGTTTA AAATTCCAGC AAGGTCTTCT GGTAGACTTC 
TTAGCTTTCC CACAAAAATT TATAGATCTC CTTCAGCAAT GTACTCAAGA ACATGCCAAA 
GAAATTCCAA GGTTTTTGCT ACAGTTAGTT TCTCCAGCAG CTATTTTGGA TAACTCACCT 
GCATTTTTAA ATGTGGTAGA GACAAATCCT TTTAAGCATC TTACACACCT CTCACTAAAA 
CTTTTACCTG GAAATGATGT GGAGATAAAG AAATTTCTCG CAGGCTGTTT GAAATGTAGC 
AAGGAAGAAA AATTATCATT GATGCAATCA CTAGATGATG CTACTAAGCA ACTGGACTTT 
ACACGAAAGA CATTAGCAGA AAAAAAACAA GAATTAGATA AGTTACGGAA TGAATGGGCG 
TCACATACAG CAGCCTTGAC AAACAAGCAT TCTCAGGAAC TGACAAATGA AAAGGAAAAA 
GCCTTGCAGG CACAGGTTCA ATATCAACAG CAGCATGAAC AACAGAAAAA AGATTTAGAA 
ATCCTCCATC AACAAAACAT CCACCAGCTA CAAAACAGAC TGTCTGAGTT AGAAGCGGCT 
AATAAAGACT TAACCGAAAG AAAATATAAA GGAGACTCCA CTATTAGAGA ACTTAAAGCA 
AAACTTTCTG GTGTTGAAGA GGAGCTACAG CGGACTAAGC AAGAAGTCCT CTCTTTGCGA 
AGAGAGAATT CTACACTAGA TGTTGAATGC CACGAGAAAG AAAAGCACGT TAATCAGCTA 
CAAACAAAAG TGGCAGTTTT AGAACAGGAA ATCAAGGATA AGGACCAGCT TGTTTTAAGA 
ACAAAAGAGG CATTTGATAC AATCCAGGAA CAAAAGGTGG TTTTAGAAGA AAATGGTGAG 
AAAAATCAAG TACAACTAGG AAAGCTTGAA GCTACAATAA AATCATTATC TGCAGAACTT 
CTGAAGGCAA ATGAAATTAT CAAGAAGTTA CAAGGGGATC TGAAAACTTT AATGGGTAAG 
TTGAAATTGA AGAATACAGT TACTATTCAG CAAGAAAAAC TCTTGGCTGA GAAGGAGGAA 
AAATTACAAA AGGAACAAAA GGAATTACAA GATGTTGGAC AGTCTCTTCG AATTAAAGAG 
CAAGAGGTAT GCAAATTACA AGAACAATTA GAAGCTACAG TTAAAAAACT TGAAGAAAGC 
AAACAACTTC TAAAAAATAA TGAAAAGTTA ATCACGTGGT TAAATAAAGA ACTAAATGAA 
AATCAGCTAG TGAGAAAGCA AGATGTATTG GGACCTTCTA CTACTCCGCC TGCACATTCC 
AGCAGCAACA CAATCAGAAG TGGAATTTCT CCTAACCTGA ATGTGGTTGA TGGTAGACTG 
ACTTACCCAA CCTGTGGGAT TGGTTATCCT GTCTCCTCTG CATTTGCATT CCAGAATACC 
TTCCCTCATT CGATATCTGC CAAAAATACC AGCCACCCTG GTTCAGGAAC AAAGGTTCAG 
TTTAATTTGC AGTTTACAAA ACCAAATGCA TCACTAGGAG ATGTTCAGTC AGGAGCAACT 
ATTAGTATGC CTTGCTCAAC TGATAAGGAA AATGGTGAAA ATGTAGGGTT GGAATCCAAA 
TACCTGAAGA AAAGGGAAGA TAGCATTCCT TTACGCGGAC TCAGCCAGAA CCTATTTAGT 
AATTCAGACC ATCAGAGAGA TGGCACTTTA GGAGCATTAC ATACATCTTC CAAACCCACA 
GCGCTCCCCT CTGCGTCTTC AGCCTATTTC CCTGGGCAGT TACCAAACAG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SASS6 ( NM_194292.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_919268.1 Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant 1, mRNA.

Price & Availability↑

CloneID	OHu24071
Clone ID Related Accession (Same CDS sequence)	NM_194292.3 , NM_194292.2
Accession Version	NM_194292.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1974bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2017-10-02
Organism	Homo sapiens(human)
Product	spindle assembly abnormal protein 6 homolog isoform 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC400869.1, AY359522.1 and BX113339.1. This sequence is a reference standard in the RefSeqGene project. On Feb 11, 2015 this sequence version replaced NM_194292.1. Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY359522.1, BX648406.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGAGCCAAG TGCTGTTCCA CCAACTAGTC CCGTTGCAGG TGAAATGCAA AGACTGTGAG 
GAGAGGAGAG TAAGTATAAG AATGAGCATT GAACTACAAT CAGTTTCTAA TCCAGTTCAC 
AGAAAGGACT TAGTTATTCG TCTGACTGAT GACACGGATC CATTTTTTTT ATATAACCTT 
GTTATATCTG AGGAAGATTT TCAAAGTTTA AAATTCCAGC AAGGTCTTCT GGTAGACTTC 
TTAGCTTTCC CACAAAAATT TATAGATCTC CTTCAGCAAT GTACTCAAGA ACATGCCAAA 
GAAATTCCAA GGTTTTTGCT ACAGTTAGTT TCTCCAGCAG CTATTTTGGA TAACTCACCT 
GCATTTTTAA ATGTGGTAGA GACAAATCCT TTTAAGCATC TTACACACCT CTCACTAAAA 
CTTTTACCTG GAAATGATGT GGAGATAAAG AAATTTCTCG CAGGCTGTTT GAAATGTAGC 
AAGGAAGAAA AATTATCATT GATGCAATCA CTAGATGATG CTACTAAGCA ACTGGACTTT 
ACACGAAAGA CATTAGCAGA AAAAAAACAA GAATTAGATA AGTTACGGAA TGAATGGGCG 
TCACATACAG CAGCCTTGAC AAACAAGCAT TCTCAGGAAC TGACAAATGA AAAGGAAAAA 
GCCTTGCAGG CACAGGTTCA ATATCAACAG CAGCATGAAC AACAGAAAAA AGATTTAGAA 
ATCCTCCATC AACAAAACAT CCACCAGCTA CAAAACAGAC TGTCTGAGTT AGAAGCGGCT 
AATAAAGACT TAACCGAAAG AAAATATAAA GGAGACTCCA CTATTAGAGA ACTTAAAGCA 
AAACTTTCTG GTGTTGAAGA GGAGCTACAG CGGACTAAGC AAGAAGTCCT CTCTTTGCGA 
AGAGAGAATT CTACACTAGA TGTTGAATGC CACGAGAAAG AAAAGCACGT TAATCAGCTA 
CAAACAAAAG TGGCAGTTTT AGAACAGGAA ATCAAGGATA AGGACCAGCT TGTTTTAAGA 
ACAAAAGAGG CATTTGATAC AATCCAGGAA CAAAAGGTGG TTTTAGAAGA AAATGGTGAG 
AAAAATCAAG TACAACTAGG AAAGCTTGAA GCTACAATAA AATCATTATC TGCAGAACTT 
CTGAAGGCAA ATGAAATTAT CAAGAAGTTA CAAGGGGATC TGAAAACTTT AATGGGTAAG 
TTGAAATTGA AGAATACAGT TACTATTCAG CAAGAAAAAC TCTTGGCTGA GAAGGAGGAA 
AAATTACAAA AGGAACAAAA GGAATTACAA GATGTTGGAC AGTCTCTTCG AATTAAAGAG 
CAAGAGGTAT GCAAATTACA AGAACAATTA GAAGCTACAG TTAAAAAACT TGAAGAAAGC 
AAACAACTTC TAAAAAATAA TGAAAAGTTA ATCACGTGGT TAAATAAAGA ACTAAATGAA 
AATCAGCTAG TGAGAAAGCA AGATGTATTG GGACCTTCTA CTACTCCGCC TGCACATTCC 
AGCAGCAACA CAATCAGAAG TGGAATTTCT CCTAACCTGA ATGTGGTTGA TGGTAGACTG 
ACTTACCCAA CCTGTGGGAT TGGTTATCCT GTCTCCTCTG CATTTGCATT CCAGAATACC 
TTCCCTCATT CGATATCTGC CAAAAATACC AGCCACCCTG GTTCAGGAAC AAAGGTTCAG 
TTTAATTTGC AGTTTACAAA ACCAAATGCA TCACTAGGAG ATGTTCAGTC AGGAGCAACT 
ATTAGTATGC CTTGCTCAAC TGATAAGGAA AATGGTGAAA ATGTAGGGTT GGAATCCAAA 
TACCTGAAGA AAAGGGAAGA TAGCATTCCT TTACGCGGAC TCAGCCAGAA CCTATTTAGT 
AATTCAGACC ATCAGAGAGA TGGCACTTTA GGAGCATTAC ATACATCTTC CAAACCCACA 
GCGCTCCCCT CTGCGTCTTC AGCCTATTTC CCTGGGCAGT TACCAAACAG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_919268.1
CDS	282..2255
Translation	MSQVLFHQLVPLQVKCKDCEERRVSIRMSIELQSVSNPVHRKDLVIRLTDDTDPFFLYNLVISEEDFQSLKFQQGLLVDFLAFPQKFIDLLQQCTQEHAKEIPRFLLQLVSPAAILDNSPAFLNVVETNPFKHLTHLSLKLLPGNDVEIKKFLAGCLKCSKEEKLSLMQSLDDATKQLDFTRKTLAEKKQELDKLRNEWASHTAALTNKHSQELTNEKEKALQAQVQYQQQHEQQKKDLEILHQQNIHQLQNRLSELEAANKDLTERKYKGDSTIRELKAKLSGVEEELQRTKQEVLSLRRENSTLDVECHEKEKHVNQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVVLEENGEKNQVQLGKLEATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEKLQKEQKELQDVGQSLRIKEQEVCKLQEQLEATVKKLEESKQLLKNNEKLITWLNKELNENQLVRKQDVLGPSTTPPAHSSSNTIRSGISPNLNVVDGRLTYPTCGIGYPVSSAFAFQNTFPHSISAKNTSHPGSGTKVQFNLQFTKPNASLGDVQSGATISMPCSTDKENGENVGLESKYLKKREDSIPLRGLSQNLFSNSDHQRDGTLGALHTSSKPTALPSASSAYFPGQLPNS

Target ORF information:

RefSeq Version	NM_194292.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant 1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_194292.2

ORF Insert Sequence:

ATGAGCCAAG TGCTGTTCCA CCAACTAGTC CCGTTGCAGG TGAAATGCAA AGACTGTGAG 
GAGAGGAGAG TAAGTATAAG AATGAGCATT GAACTACAAT CAGTTTCTAA TCCAGTTCAC 
AGAAAGGACT TAGTTATTCG TCTGACTGAT GACACGGATC CATTTTTTTT ATATAACCTT 
GTTATATCTG AGGAAGATTT TCAAAGTTTA AAATTCCAGC AAGGTCTTCT GGTAGACTTC 
TTAGCTTTCC CACAAAAATT TATAGATCTC CTTCAGCAAT GTACTCAAGA ACATGCCAAA 
GAAATTCCAA GGTTTTTGCT ACAGTTAGTT TCTCCAGCAG CTATTTTGGA TAACTCACCT 
GCATTTTTAA ATGTGGTAGA GACAAATCCT TTTAAGCATC TTACACACCT CTCACTAAAA 
CTTTTACCTG GAAATGATGT GGAGATAAAG AAATTTCTCG CAGGCTGTTT GAAATGTAGC 
AAGGAAGAAA AATTATCATT GATGCAATCA CTAGATGATG CTACTAAGCA ACTGGACTTT 
ACACGAAAGA CATTAGCAGA AAAAAAACAA GAATTAGATA AGTTACGGAA TGAATGGGCG 
TCACATACAG CAGCCTTGAC AAACAAGCAT TCTCAGGAAC TGACAAATGA AAAGGAAAAA 
GCCTTGCAGG CACAGGTTCA ATATCAACAG CAGCATGAAC AACAGAAAAA AGATTTAGAA 
ATCCTCCATC AACAAAACAT CCACCAGCTA CAAAACAGAC TGTCTGAGTT AGAAGCGGCT 
AATAAAGACT TAACCGAAAG AAAATATAAA GGAGACTCCA CTATTAGAGA ACTTAAAGCA 
AAACTTTCTG GTGTTGAAGA GGAGCTACAG CGGACTAAGC AAGAAGTCCT CTCTTTGCGA 
AGAGAGAATT CTACACTAGA TGTTGAATGC CACGAGAAAG AAAAGCACGT TAATCAGCTA 
CAAACAAAAG TGGCAGTTTT AGAACAGGAA ATCAAGGATA AGGACCAGCT TGTTTTAAGA 
ACAAAAGAGG CATTTGATAC AATCCAGGAA CAAAAGGTGG TTTTAGAAGA AAATGGTGAG 
AAAAATCAAG TACAACTAGG AAAGCTTGAA GCTACAATAA AATCATTATC TGCAGAACTT 
CTGAAGGCAA ATGAAATTAT CAAGAAGTTA CAAGGGGATC TGAAAACTTT AATGGGTAAG 
TTGAAATTGA AGAATACAGT TACTATTCAG CAAGAAAAAC TCTTGGCTGA GAAGGAGGAA 
AAATTACAAA AGGAACAAAA GGAATTACAA GATGTTGGAC AGTCTCTTCG AATTAAAGAG 
CAAGAGGTAT GCAAATTACA AGAACAATTA GAAGCTACAG TTAAAAAACT TGAAGAAAGC 
AAACAACTTC TAAAAAATAA TGAAAAGTTA ATCACGTGGT TAAATAAAGA ACTAAATGAA 
AATCAGCTAG TGAGAAAGCA AGATGTATTG GGACCTTCTA CTACTCCGCC TGCACATTCC 
AGCAGCAACA CAATCAGAAG TGGAATTTCT CCTAACCTGA ATGTGGTTGA TGGTAGACTG 
ACTTACCCAA CCTGTGGGAT TGGTTATCCT GTCTCCTCTG CATTTGCATT CCAGAATACC 
TTCCCTCATT CGATATCTGC CAAAAATACC AGCCACCCTG GTTCAGGAAC AAAGGTTCAG 
TTTAATTTGC AGTTTACAAA ACCAAATGCA TCACTAGGAG ATGTTCAGTC AGGAGCAACT 
ATTAGTATGC CTTGCTCAAC TGATAAGGAA AATGGTGAAA ATGTAGGGTT GGAATCCAAA 
TACCTGAAGA AAAGGGAAGA TAGCATTCCT TTACGCGGAC TCAGCCAGAA CCTATTTAGT 
AATTCAGACC ATCAGAGAGA TGGCACTTTA GGAGCATTAC ATACATCTTC CAAACCCACA 
GCGCTCCCCT CTGCGTCTTC AGCCTATTTC CCTGGGCAGT TACCAAACAG TTAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SASS6 ( NM_001304829.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291758.1 Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant 2, mRNA.

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CloneID	OHu77228
Clone ID Related Accession (Same CDS sequence)	NM_001304829.2 , NM_001304829.1
Accession Version	NM_001304829.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1473bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-05-31
Organism	Homo sapiens(human)
Product	spindle assembly abnormal protein 6 homolog isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC400869.1, BC101026.3 and AY359522.1. On Jun 1, 2019 this sequence version replaced NM_001304829.1. Transcript Variant: This variant (2) lacks an alternate exon at the 5' end compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.186616.1, SRR1803612.102535.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAATCAC TAGATGATGC TACTAAGCAA CTGGACTTTA CACGAAAGAC ATTAGCAGAA 
AAAAAACAAG AATTAGATAA GTTACGGAAT GAATGGGCGT CACATACAGC AGCCTTGACA 
AACAAGCATT CTCAGGAACT GACAAATGAA AAGGAAAAAG CCTTGCAGGC ACAGGTTCAA 
TATCAACAGC AGCATGAACA ACAGAAAAAA GATTTAGAAA TCCTCCATCA ACAAAACATC 
CACCAGCTAC AAAACAGACT GTCTGAGTTA GAAGCGGCTA ATAAAGACTT AACCGAAAGA 
AAATATAAAG GAGACTCCAC TATTAGAGAA CTTAAAGCAA AACTTTCTGG TGTTGAAGAG 
GAGCTACAGC GGACTAAGCA AGAAGTCCTC TCTTTGCGAA GAGAGAATTC TACACTAGAT 
GTTGAATGCC ACGAGAAAGA AAAGCACGTT AATCAGCTAC AAACAAAAGT GGCAGTTTTA 
GAACAGGAAA TCAAGGATAA GGACCAGCTT GTTTTAAGAA CAAAAGAGGC ATTTGATACA 
ATCCAGGAAC AAAAGGTGGT TTTAGAAGAA AATGGTGAGA AAAATCAAGT ACAACTAGGA 
AAGCTTGAAG CTACAATAAA ATCATTATCT GCAGAACTTC TGAAGGCAAA TGAAATTATC 
AAGAAGTTAC AAGGGGATCT GAAAACTTTA ATGGGTAAGT TGAAATTGAA GAATACAGTT 
ACTATTCAGC AAGAAAAACT CTTGGCTGAG AAGGAGGAAA AATTACAAAA GGAACAAAAG 
GAATTACAAG ATGTTGGACA GTCTCTTCGA ATTAAAGAGC AAGAGGTATG CAAATTACAA 
GAACAATTAG AAGCTACAGT TAAAAAACTT GAAGAAAGCA AACAACTTCT AAAAAATAAT 
GAAAAGTTAA TCACGTGGTT AAATAAAGAA CTAAATGAAA ATCAGCTAGT GAGAAAGCAA 
GATGTATTGG GACCTTCTAC TACTCCGCCT GCACATTCCA GCAGCAACAC AATCAGAAGT 
GGAATTTCTC CTAACCTGAA TGTGGTTGAT GGTAGACTGA CTTACCCAAC CTGTGGGATT 
GGTTATCCTG TCTCCTCTGC ATTTGCATTC CAGAATACCT TCCCTCATTC GATATCTGCC 
AAAAATACCA GCCACCCTGG TTCAGGAACA AAGGTTCAGT TTAATTTGCA GTTTACAAAA 
CCAAATGCAT CACTAGGAGA TGTTCAGTCA GGAGCAACTA TTAGTATGCC TTGCTCAACT 
GATAAGGAAA ATGGTGAAAA TGTAGGGTTG GAATCCAAAT ACCTGAAGAA AAGGGAAGAT 
AGCATTCCTT TACGCGGACT CAGCCAGAAC CTATTTAGTA ATTCAGACCA TCAGAGAGAT 
GGCACTTTAG GAGCATTACA TACATCTTCC AAACCCACAG CGCTCCCCTC TGCGTCTTCA 
GCCTATTTCC CTGGGCAGTT ACCAAACAGT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291758.1
CDS	538..2010
Translation	MQSLDDATKQLDFTRKTLAEKKQELDKLRNEWASHTAALTNKHSQELTNEKEKALQAQVQYQQQHEQQKKDLEILHQQNIHQLQNRLSELEAANKDLTERKYKGDSTIRELKAKLSGVEEELQRTKQEVLSLRRENSTLDVECHEKEKHVNQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVVLEENGEKNQVQLGKLEATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEKLQKEQKELQDVGQSLRIKEQEVCKLQEQLEATVKKLEESKQLLKNNEKLITWLNKELNENQLVRKQDVLGPSTTPPAHSSSNTIRSGISPNLNVVDGRLTYPTCGIGYPVSSAFAFQNTFPHSISAKNTSHPGSGTKVQFNLQFTKPNASLGDVQSGATISMPCSTDKENGENVGLESKYLKKREDSIPLRGLSQNLFSNSDHQRDGTLGALHTSSKPTALPSASSAYFPGQLPNS

Target ORF information:

RefSeq Version	NM_001304829.2
Organism	Homo sapiens(human)
Definition	Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304829.2

ORF Insert Sequence:

ATGCAATCAC TAGATGATGC TACTAAGCAA CTGGACTTTA CACGAAAGAC ATTAGCAGAA 
AAAAAACAAG AATTAGATAA GTTACGGAAT GAATGGGCGT CACATACAGC AGCCTTGACA 
AACAAGCATT CTCAGGAACT GACAAATGAA AAGGAAAAAG CCTTGCAGGC ACAGGTTCAA 
TATCAACAGC AGCATGAACA ACAGAAAAAA GATTTAGAAA TCCTCCATCA ACAAAACATC 
CACCAGCTAC AAAACAGACT GTCTGAGTTA GAAGCGGCTA ATAAAGACTT AACCGAAAGA 
AAATATAAAG GAGACTCCAC TATTAGAGAA CTTAAAGCAA AACTTTCTGG TGTTGAAGAG 
GAGCTACAGC GGACTAAGCA AGAAGTCCTC TCTTTGCGAA GAGAGAATTC TACACTAGAT 
GTTGAATGCC ACGAGAAAGA AAAGCACGTT AATCAGCTAC AAACAAAAGT GGCAGTTTTA 
GAACAGGAAA TCAAGGATAA GGACCAGCTT GTTTTAAGAA CAAAAGAGGC ATTTGATACA 
ATCCAGGAAC AAAAGGTGGT TTTAGAAGAA AATGGTGAGA AAAATCAAGT ACAACTAGGA 
AAGCTTGAAG CTACAATAAA ATCATTATCT GCAGAACTTC TGAAGGCAAA TGAAATTATC 
AAGAAGTTAC AAGGGGATCT GAAAACTTTA ATGGGTAAGT TGAAATTGAA GAATACAGTT 
ACTATTCAGC AAGAAAAACT CTTGGCTGAG AAGGAGGAAA AATTACAAAA GGAACAAAAG 
GAATTACAAG ATGTTGGACA GTCTCTTCGA ATTAAAGAGC AAGAGGTATG CAAATTACAA 
GAACAATTAG AAGCTACAGT TAAAAAACTT GAAGAAAGCA AACAACTTCT AAAAAATAAT 
GAAAAGTTAA TCACGTGGTT AAATAAAGAA CTAAATGAAA ATCAGCTAGT GAGAAAGCAA 
GATGTATTGG GACCTTCTAC TACTCCGCCT GCACATTCCA GCAGCAACAC AATCAGAAGT 
GGAATTTCTC CTAACCTGAA TGTGGTTGAT GGTAGACTGA CTTACCCAAC CTGTGGGATT 
GGTTATCCTG TCTCCTCTGC ATTTGCATTC CAGAATACCT TCCCTCATTC GATATCTGCC 
AAAAATACCA GCCACCCTGG TTCAGGAACA AAGGTTCAGT TTAATTTGCA GTTTACAAAA 
CCAAATGCAT CACTAGGAGA TGTTCAGTCA GGAGCAACTA TTAGTATGCC TTGCTCAACT 
GATAAGGAAA ATGGTGAAAA TGTAGGGTTG GAATCCAAAT ACCTGAAGAA AAGGGAAGAT 
AGCATTCCTT TACGCGGACT CAGCCAGAAC CTATTTAGTA ATTCAGACCA TCAGAGAGAT 
GGCACTTTAG GAGCATTACA TACATCTTCC AAACCCACAG CGCTCCCCTC TGCGTCTTCA 
GCCTATTTCC CTGGGCAGTT ACCAAACAGT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SASS6 ( NM_001304829.1 ) cDNA ORF clone, Homo sapiens(human) -> NP_001291758.1 Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant 2, mRNA.

Price & Availability↑

CloneID	OHu77228
Clone ID Related Accession (Same CDS sequence)	NM_001304829.2 , NM_001304829.1
Accession Version	NM_001304829.1	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1473bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2018-06-30
Organism	Homo sapiens(human)
Product	spindle assembly abnormal protein 6 homolog isoform 2
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DC400869.1, BC101026.3, AY359522.1 and BX113339.1. Transcript Variant: This variant (2) lacks an alternate exon at the 5' end compared to variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR1803611.186616.1, SRR1803612.102535.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1965299, SAMEA1966682 [ECO:0000350] ##Evidence-Data-END## COMPLETENESS: complete on the 3' end.

ATGCAATCAC TAGATGATGC TACTAAGCAA CTGGACTTTA CACGAAAGAC ATTAGCAGAA 
AAAAAACAAG AATTAGATAA GTTACGGAAT GAATGGGCGT CACATACAGC AGCCTTGACA 
AACAAGCATT CTCAGGAACT GACAAATGAA AAGGAAAAAG CCTTGCAGGC ACAGGTTCAA 
TATCAACAGC AGCATGAACA ACAGAAAAAA GATTTAGAAA TCCTCCATCA ACAAAACATC 
CACCAGCTAC AAAACAGACT GTCTGAGTTA GAAGCGGCTA ATAAAGACTT AACCGAAAGA 
AAATATAAAG GAGACTCCAC TATTAGAGAA CTTAAAGCAA AACTTTCTGG TGTTGAAGAG 
GAGCTACAGC GGACTAAGCA AGAAGTCCTC TCTTTGCGAA GAGAGAATTC TACACTAGAT 
GTTGAATGCC ACGAGAAAGA AAAGCACGTT AATCAGCTAC AAACAAAAGT GGCAGTTTTA 
GAACAGGAAA TCAAGGATAA GGACCAGCTT GTTTTAAGAA CAAAAGAGGC ATTTGATACA 
ATCCAGGAAC AAAAGGTGGT TTTAGAAGAA AATGGTGAGA AAAATCAAGT ACAACTAGGA 
AAGCTTGAAG CTACAATAAA ATCATTATCT GCAGAACTTC TGAAGGCAAA TGAAATTATC 
AAGAAGTTAC AAGGGGATCT GAAAACTTTA ATGGGTAAGT TGAAATTGAA GAATACAGTT 
ACTATTCAGC AAGAAAAACT CTTGGCTGAG AAGGAGGAAA AATTACAAAA GGAACAAAAG 
GAATTACAAG ATGTTGGACA GTCTCTTCGA ATTAAAGAGC AAGAGGTATG CAAATTACAA 
GAACAATTAG AAGCTACAGT TAAAAAACTT GAAGAAAGCA AACAACTTCT AAAAAATAAT 
GAAAAGTTAA TCACGTGGTT AAATAAAGAA CTAAATGAAA ATCAGCTAGT GAGAAAGCAA 
GATGTATTGG GACCTTCTAC TACTCCGCCT GCACATTCCA GCAGCAACAC AATCAGAAGT 
GGAATTTCTC CTAACCTGAA TGTGGTTGAT GGTAGACTGA CTTACCCAAC CTGTGGGATT 
GGTTATCCTG TCTCCTCTGC ATTTGCATTC CAGAATACCT TCCCTCATTC GATATCTGCC 
AAAAATACCA GCCACCCTGG TTCAGGAACA AAGGTTCAGT TTAATTTGCA GTTTACAAAA 
CCAAATGCAT CACTAGGAGA TGTTCAGTCA GGAGCAACTA TTAGTATGCC TTGCTCAACT 
GATAAGGAAA ATGGTGAAAA TGTAGGGTTG GAATCCAAAT ACCTGAAGAA AAGGGAAGAT 
AGCATTCCTT TACGCGGACT CAGCCAGAAC CTATTTAGTA ATTCAGACCA TCAGAGAGAT 
GGCACTTTAG GAGCATTACA TACATCTTCC AAACCCACAG CGCTCCCCTC TGCGTCTTCA 
GCCTATTTCC CTGGGCAGTT ACCAAACAGT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_001291758.1
CDS	703..2175
Translation	MQSLDDATKQLDFTRKTLAEKKQELDKLRNEWASHTAALTNKHSQELTNEKEKALQAQVQYQQQHEQQKKDLEILHQQNIHQLQNRLSELEAANKDLTERKYKGDSTIRELKAKLSGVEEELQRTKQEVLSLRRENSTLDVECHEKEKHVNQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVVLEENGEKNQVQLGKLEATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEKLQKEQKELQDVGQSLRIKEQEVCKLQEQLEATVKKLEESKQLLKNNEKLITWLNKELNENQLVRKQDVLGPSTTPPAHSSSNTIRSGISPNLNVVDGRLTYPTCGIGYPVSSAFAFQNTFPHSISAKNTSHPGSGTKVQFNLQFTKPNASLGDVQSGATISMPCSTDKENGENVGLESKYLKKREDSIPLRGLSQNLFSNSDHQRDGTLGALHTSSKPTALPSASSAYFPGQLPNS

Target ORF information:

RefSeq Version	NM_001304829.1
Organism	Homo sapiens(human)
Definition	Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant 2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_001304829.1

ORF Insert Sequence:

ATGCAATCAC TAGATGATGC TACTAAGCAA CTGGACTTTA CACGAAAGAC ATTAGCAGAA 
AAAAAACAAG AATTAGATAA GTTACGGAAT GAATGGGCGT CACATACAGC AGCCTTGACA 
AACAAGCATT CTCAGGAACT GACAAATGAA AAGGAAAAAG CCTTGCAGGC ACAGGTTCAA 
TATCAACAGC AGCATGAACA ACAGAAAAAA GATTTAGAAA TCCTCCATCA ACAAAACATC 
CACCAGCTAC AAAACAGACT GTCTGAGTTA GAAGCGGCTA ATAAAGACTT AACCGAAAGA 
AAATATAAAG GAGACTCCAC TATTAGAGAA CTTAAAGCAA AACTTTCTGG TGTTGAAGAG 
GAGCTACAGC GGACTAAGCA AGAAGTCCTC TCTTTGCGAA GAGAGAATTC TACACTAGAT 
GTTGAATGCC ACGAGAAAGA AAAGCACGTT AATCAGCTAC AAACAAAAGT GGCAGTTTTA 
GAACAGGAAA TCAAGGATAA GGACCAGCTT GTTTTAAGAA CAAAAGAGGC ATTTGATACA 
ATCCAGGAAC AAAAGGTGGT TTTAGAAGAA AATGGTGAGA AAAATCAAGT ACAACTAGGA 
AAGCTTGAAG CTACAATAAA ATCATTATCT GCAGAACTTC TGAAGGCAAA TGAAATTATC 
AAGAAGTTAC AAGGGGATCT GAAAACTTTA ATGGGTAAGT TGAAATTGAA GAATACAGTT 
ACTATTCAGC AAGAAAAACT CTTGGCTGAG AAGGAGGAAA AATTACAAAA GGAACAAAAG 
GAATTACAAG ATGTTGGACA GTCTCTTCGA ATTAAAGAGC AAGAGGTATG CAAATTACAA 
GAACAATTAG AAGCTACAGT TAAAAAACTT GAAGAAAGCA AACAACTTCT AAAAAATAAT 
GAAAAGTTAA TCACGTGGTT AAATAAAGAA CTAAATGAAA ATCAGCTAGT GAGAAAGCAA 
GATGTATTGG GACCTTCTAC TACTCCGCCT GCACATTCCA GCAGCAACAC AATCAGAAGT 
GGAATTTCTC CTAACCTGAA TGTGGTTGAT GGTAGACTGA CTTACCCAAC CTGTGGGATT 
GGTTATCCTG TCTCCTCTGC ATTTGCATTC CAGAATACCT TCCCTCATTC GATATCTGCC 
AAAAATACCA GCCACCCTGG TTCAGGAACA AAGGTTCAGT TTAATTTGCA GTTTACAAAA 
CCAAATGCAT CACTAGGAGA TGTTCAGTCA GGAGCAACTA TTAGTATGCC TTGCTCAACT 
GATAAGGAAA ATGGTGAAAA TGTAGGGTTG GAATCCAAAT ACCTGAAGAA AAGGGAAGAT 
AGCATTCCTT TACGCGGACT CAGCCAGAAC CTATTTAGTA ATTCAGACCA TCAGAGAGAT 
GGCACTTTAG GAGCATTACA TACATCTTCC AAACCCACAG CGCTCCCCTC TGCGTCTTCA 
GCCTATTTCC CTGGGCAGTT ACCAAACAGT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

SASS6 ( XM_017000486.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_016855975.1 Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu83246
Clone ID Related Accession (Same CDS sequence)	XM_017000486.1
Accession Version	XM_017000486.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1893bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	spindle assembly abnormal protein 6 homolog isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000001.11) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGAGCATTG AACTACAATC AGTTTCTAAT CCAGTTCACA GAAAGGACTT AGTTATTCGT 
CTGACTGATG ACACGGATCC ATTTTTTTTA TATAACCTTG TTATATCTGA GGAAGATTTT 
CAAAGTTTAA AATTCCAGCA AGGTCTTCTG GTAGACTTCT TAGCTTTCCC ACAAAAATTT 
ATAGATCTCC TTCAGCAATG TACTCAAGAA CATGCCAAAG AAATTCCAAG GTTTTTGCTA 
CAGTTAGTTT CTCCAGCAGC TATTTTGGAT AACTCACCTG CATTTTTAAA TGTGGTAGAG 
ACAAATCCTT TTAAGCATCT TACACACCTC TCACTAAAAC TTTTACCTGG AAATGATGTG 
GAGATAAAGA AATTTCTCGC AGGCTGTTTG AAATGTAGCA AGGAAGAAAA ATTATCATTG 
ATGCAATCAC TAGATGATGC TACTAAGCAA CTGGACTTTA CACGAAAGAC ATTAGCAGAA 
AAAAAACAAG AATTAGATAA GTTACGGAAT GAATGGGCGT CACATACAGC AGCCTTGACA 
AACAAGCATT CTCAGGAACT GACAAATGAA AAGGAAAAAG CCTTGCAGGC ACAGGTTCAA 
TATCAACAGC AGCATGAACA ACAGAAAAAA GATTTAGAAA TCCTCCATCA ACAAAACATC 
CACCAGCTAC AAAACAGACT GTCTGAGTTA GAAGCGGCTA ATAAAGACTT AACCGAAAGA 
AAATATAAAG GAGACTCCAC TATTAGAGAA CTTAAAGCAA AACTTTCTGG TGTTGAAGAG 
GAGCTACAGC GGACTAAGCA AGAAGTCCTC TCTTTGCGAA GAGAGAATTC TACACTAGAT 
GTTGAATGCC ACGAGAAAGA AAAGCACGTT AATCAGCTAC AAACAAAAGT GGCAGTTTTA 
GAACAGGAAA TCAAGGATAA GGACCAGCTT GTTTTAAGAA CAAAAGAGGC ATTTGATACA 
ATCCAGGAAC AAAAGGTGGT TTTAGAAGAA AATGGTGAGA AAAATCAAGT ACAACTAGGA 
AAGCTTGAAG CTACAATAAA ATCATTATCT GCAGAACTTC TGAAGGCAAA TGAAATTATC 
AAGAAGTTAC AAGGGGATCT GAAAACTTTA ATGGGTAAGT TGAAATTGAA GAATACAGTT 
ACTATTCAGC AAGAAAAACT CTTGGCTGAG AAGGAGGAAA AATTACAAAA GGAACAAAAG 
GAATTACAAG ATGTTGGACA GTCTCTTCGA ATTAAAGAGC AAGAGGTATG CAAATTACAA 
GAACAATTAG AAGCTACAGT TAAAAAACTT GAAGAAAGCA AACAACTTCT AAAAAATAAT 
GAAAAGTTAA TCACGTGGTT AAATAAAGAA CTAAATGAAA ATCAGCTAGT GAGAAAGCAA 
GATGTATTGG GACCTTCTAC TACTCCGCCT GCACATTCCA GCAGCAACAC AATCAGAAGT 
GGAATTTCTC CTAACCTGAA TGTGGTTGAT GGTAGACTGA CTTACCCAAC CTGTGGGATT 
GGTTATCCTG TCTCCTCTGC ATTTGCATTC CAGAATACCT TCCCTCATTC GATATCTGCC 
AAAAATACCA GCCACCCTGG TTCAGGAACA AAGGTTCAGT TTAATTTGCA GTTTACAAAA 
CCAAATGCAT CACTAGGAGA TGTTCAGTCA GGAGCAACTA TTAGTATGCC TTGCTCAACT 
GATAAGGAAA ATGGTGAAAA TGTAGGGTTG GAATCCAAAT ACCTGAAGAA AAGGGAAGAT 
AGCATTCCTT TACGCGGACT CAGCCAGAAC CTATTTAGTA ATTCAGACCA TCAGAGAGAT 
GGCACTTTAG GAGCATTACA TACATCTTCC AAACCCACAG CGCTCCCCTC TGCGTCTTCA 
GCCTATTTCC CTGGGCAGTT ACCAAACAGT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_016855975.1
CDS	129..2021
Translation	MSIELQSVSNPVHRKDLVIRLTDDTDPFFLYNLVISEEDFQSLKFQQGLLVDFLAFPQKFIDLLQQCTQEHAKEIPRFLLQLVSPAAILDNSPAFLNVVETNPFKHLTHLSLKLLPGNDVEIKKFLAGCLKCSKEEKLSLMQSLDDATKQLDFTRKTLAEKKQELDKLRNEWASHTAALTNKHSQELTNEKEKALQAQVQYQQQHEQQKKDLEILHQQNIHQLQNRLSELEAANKDLTERKYKGDSTIRELKAKLSGVEEELQRTKQEVLSLRRENSTLDVECHEKEKHVNQLQTKVAVLEQEIKDKDQLVLRTKEAFDTIQEQKVVLEENGEKNQVQLGKLEATIKSLSAELLKANEIIKKLQGDLKTLMGKLKLKNTVTIQQEKLLAEKEEKLQKEQKELQDVGQSLRIKEQEVCKLQEQLEATVKKLEESKQLLKNNEKLITWLNKELNENQLVRKQDVLGPSTTPPAHSSSNTIRSGISPNLNVVDGRLTYPTCGIGYPVSSAFAFQNTFPHSISAKNTSHPGSGTKVQFNLQFTKPNASLGDVQSGATISMPCSTDKENGENVGLESKYLKKREDSIPLRGLSQNLFSNSDHQRDGTLGALHTSSKPTALPSASSAYFPGQLPNS

Target ORF information:

RefSeq Version	XM_017000486.1
Organism	Homo sapiens(human)
Definition	Homo sapiens SAS-6 centriolar assembly protein (SASS6), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_017000486.1

ORF Insert Sequence:

ATGAGCATTG AACTACAATC AGTTTCTAAT CCAGTTCACA GAAAGGACTT AGTTATTCGT 
CTGACTGATG ACACGGATCC ATTTTTTTTA TATAACCTTG TTATATCTGA GGAAGATTTT 
CAAAGTTTAA AATTCCAGCA AGGTCTTCTG GTAGACTTCT TAGCTTTCCC ACAAAAATTT 
ATAGATCTCC TTCAGCAATG TACTCAAGAA CATGCCAAAG AAATTCCAAG GTTTTTGCTA 
CAGTTAGTTT CTCCAGCAGC TATTTTGGAT AACTCACCTG CATTTTTAAA TGTGGTAGAG 
ACAAATCCTT TTAAGCATCT TACACACCTC TCACTAAAAC TTTTACCTGG AAATGATGTG 
GAGATAAAGA AATTTCTCGC AGGCTGTTTG AAATGTAGCA AGGAAGAAAA ATTATCATTG 
ATGCAATCAC TAGATGATGC TACTAAGCAA CTGGACTTTA CACGAAAGAC ATTAGCAGAA 
AAAAAACAAG AATTAGATAA GTTACGGAAT GAATGGGCGT CACATACAGC AGCCTTGACA 
AACAAGCATT CTCAGGAACT GACAAATGAA AAGGAAAAAG CCTTGCAGGC ACAGGTTCAA 
TATCAACAGC AGCATGAACA ACAGAAAAAA GATTTAGAAA TCCTCCATCA ACAAAACATC 
CACCAGCTAC AAAACAGACT GTCTGAGTTA GAAGCGGCTA ATAAAGACTT AACCGAAAGA 
AAATATAAAG GAGACTCCAC TATTAGAGAA CTTAAAGCAA AACTTTCTGG TGTTGAAGAG 
GAGCTACAGC GGACTAAGCA AGAAGTCCTC TCTTTGCGAA GAGAGAATTC TACACTAGAT 
GTTGAATGCC ACGAGAAAGA AAAGCACGTT AATCAGCTAC AAACAAAAGT GGCAGTTTTA 
GAACAGGAAA TCAAGGATAA GGACCAGCTT GTTTTAAGAA CAAAAGAGGC ATTTGATACA 
ATCCAGGAAC AAAAGGTGGT TTTAGAAGAA AATGGTGAGA AAAATCAAGT ACAACTAGGA 
AAGCTTGAAG CTACAATAAA ATCATTATCT GCAGAACTTC TGAAGGCAAA TGAAATTATC 
AAGAAGTTAC AAGGGGATCT GAAAACTTTA ATGGGTAAGT TGAAATTGAA GAATACAGTT 
ACTATTCAGC AAGAAAAACT CTTGGCTGAG AAGGAGGAAA AATTACAAAA GGAACAAAAG 
GAATTACAAG ATGTTGGACA GTCTCTTCGA ATTAAAGAGC AAGAGGTATG CAAATTACAA 
GAACAATTAG AAGCTACAGT TAAAAAACTT GAAGAAAGCA AACAACTTCT AAAAAATAAT 
GAAAAGTTAA TCACGTGGTT AAATAAAGAA CTAAATGAAA ATCAGCTAGT GAGAAAGCAA 
GATGTATTGG GACCTTCTAC TACTCCGCCT GCACATTCCA GCAGCAACAC AATCAGAAGT 
GGAATTTCTC CTAACCTGAA TGTGGTTGAT GGTAGACTGA CTTACCCAAC CTGTGGGATT 
GGTTATCCTG TCTCCTCTGC ATTTGCATTC CAGAATACCT TCCCTCATTC GATATCTGCC 
AAAAATACCA GCCACCCTGG TTCAGGAACA AAGGTTCAGT TTAATTTGCA GTTTACAAAA 
CCAAATGCAT CACTAGGAGA TGTTCAGTCA GGAGCAACTA TTAGTATGCC TTGCTCAACT 
GATAAGGAAA ATGGTGAAAA TGTAGGGTTG GAATCCAAAT ACCTGAAGAA AAGGGAAGAT 
AGCATTCCTT TACGCGGACT CAGCCAGAAC CTATTTAGTA ATTCAGACCA TCAGAGAGAT 
GGCACTTTAG GAGCATTACA TACATCTTCC AAACCCACAG CGCTCCCCTC TGCGTCTTCA 
GCCTATTTCC CTGGGCAGTT ACCAAACAGT TAA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

The PLK4-STIL-SAS-6 module at the core of centriole duplication.
Biochemical Society transactions44(5)1253-1263(2016 10)
Arquint C,Nigg EA

SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nature cell biology18(4)393-403(2016 Apr)
Hilbert M,Noga A,Frey D,Hamel V,Guichard P,Kraatz SH,Pfreundschuh M,Hosner S,Fl?ckiger I,Jaussi R,Wieser MM,Thieltges KM,Deupi X,M?ller DJ,Kammerer RA,G?nczy P,Hirono M,Steinmetz MO

Human SAS-6 C-Terminus Nucleates and Promotes Microtubule Assembly in Vitro by Binding to Microtubules.
Biochemistry54(41)6413-22(2015 Oct)
Gupta H,Badarudeen B,George A,Thomas GE,Gireesh KK,Manna TK

SASS6 overexpression is associated with mitotic chromosomal abnormalities and a poor prognosis in patients with colorectal cancer.
Oncology reports34(2)727-38(2015 Aug)
Shinmura K,Kato H,Kawanishi Y,Nagura K,Kamo T,Okubo Y,Inoue Y,Kurabe N,Du C,Iwaizumi M,Kurachi K,Nakamura T,Sugimura H

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SASS6 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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