NAGS cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	NAGS
Entrez Gene ID	162417
Full Name	N-acetylglutamate synthase
Synonyms	AGAS,ARGA
General protein information	Preferred Names N-acetylglutamate synthase Names N-acetylglutamate synthase, mitochondrial amino-acid acetyltransferase
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: 17 Map Location: 17q21.31
Summary	The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia. [provided by RefSeq, Jul 2008].
Disorder MIM:	608300
Disorder Html:	N-acetylglutamate synthase deficiency, 237310 (3)

mRNA and Protein(s)

mRNA	Protein	Name
NM_153006.2	NP_694551.1	N-acetylglutamate synthase, mitochondrial
XM_011524438.1	XP_011522740.1	N-acetylglutamate synthase, mitochondrial isoform X1
NM_153006.3	NP_694551.1	N-acetylglutamate synthase, mitochondrial
XM_011524439.2	XP_011522741.1	N-acetylglutamate synthase, mitochondrial isoform X2

Pathways from BioSystems

Homologies

	NAGS	XP_001114030.1
Eremothecium gossypii	AGOS_ADL062W	NP_984034.2
Xenopus tropicalis (tropical clawed frog)	nags	XP_002935592.1
Canis lupus familiaris (dog)	NAGS	XP_548066.2
Rattus norvegicus (Norway rat)	Nags	NP_001100523.1
Pan troglodytes (chimpanzee)	NAGS	XP_001152548.1
Bos taurus (cattle)	NAGS	XP_002696085.1
Mus musculus (house mouse)	Nags	NP_665828.1
Danio rerio (zebrafish)	LOC557716	XP_685919.3
Homo sapiens (human)	NAGS	NP_694551.1

Gene Ontology
Bibliography

Related articles in PubMed

A novel UPLC-MS/MS based method to determine the activity of N-acetylglutamate synthase in liver tissue.
Dercksen M, Duran M, IJlst L, Kulik W, Ruiter JP, van Cruchten A, Tuchman M, Wanders RJ
Molecular genetics and metabolism119(4)307-310(2016 12)

Understanding N-Acetyl-L-Glutamate Synthase Deficiency: Mutational Spectrum, Impact of Clinical Mutations on Enzyme Functionality, and Structural Considerations.
Sancho-Vaello E, Marco-Mar?n C, Gougeard N, Fern?ndez-Murga L, R?fenacht V, Mustedanagic M, Rubio V, H?berle J
Human mutation37(7)679-94(2016 07)

Inhibition of N-acetylglutamate synthase by various monocarboxylic and dicarboxylic short-chain coenzyme A esters and the production of alternative glutamate esters.
Dercksen M, IJlst L, Duran M, Mienie LJ, van Cruchten A, van der Westhuizen FH, Wanders RJ
Biochimica et biophysica acta1842(12 Pt A)2510-6(2014 Dec)

Crystal structure of the N-acetyltransferase domain of human N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate provides insights into its catalytic and regulatory mechanisms.
Zhao G, Jin Z, Allewell NM, Tuchman M, Shi D
PloS one8(7)e70369(2013)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

The specificity of the assay was validated by demonstrating a complete deficiency of NAGS in liver homogenates from Nags -/- mice. CONCLUSION: The novel NAGS enzyme assay reported herein can be used for the diagnosis of inherited NAGS deficiency and may also be of value in the study of secondary hyperammonemia present in various inborn errors of metabolism as well as drug treatment.
Title: A novel UPLC-MS/MS based method to determine the activity of N-acetylglutamate synthase in liver tissue.

Results identified 36 NAGS mutations in NAGSD patients; 61% of which are missense mutations. Phenotypes associated with these mutations in the GNAT domain are more severe than phenotypes of that of amino acid kinase domain. Enzyme activity and stability assays with 12 mutations, together with in silico structural analysis, support the pathogenic role of most NAGSD-associated mutations found.
Title: Understanding N-Acetyl-L-Glutamate Synthase Deficiency: Mutational Spectrum, Impact of Clinical Mutations on Enzyme Functionality, and Structural Considerations.

Data indicate the formation of alternative N-acylglutamates by N-acetylglutamate synthase (NAGS).
Title: Inhibition of N-acetylglutamate synthase by various monocarboxylic and dicarboxylic short-chain coenzyme A esters and the production of alternative glutamate esters.

Sp1, CREB, HNF-1, and NF-Y, known to be responsive to hormones and diet, regulate NAGS transcription
Title: Transcriptional regulation of N-acetylglutamate synthase.

Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.

The following NAGS gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the NAGS cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu77174	XM_011524439.2 Latest version!	Homo sapiens N-acetylglutamate synthase (NAGS), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	5-7	$223.30 $319.00
OHu24956	NM_153006.3 Latest version!	Homo sapiens N-acetylglutamate synthase (NAGS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$314.30 $449.00
OHu77173	XM_011524438.1 Latest version!	Homo sapiens N-acetylglutamate synthase (NAGS), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$223.30 $319.00
View Old Accession Versions >>
OHu24956	NM_153006.2	Homo sapiens N-acetylglutamate synthase (NAGS), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$314.30 $449.00
Hide Old Accession Versions >>

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

NAGS ( XM_011524439.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011522741.1 Homo sapiens N-acetylglutamate synthase (NAGS), transcript variant X2, mRNA.

Price & Availability↑

CloneID	OHu77174
Clone ID Related Accession (Same CDS sequence)	XM_011524439.2
Accession Version	XM_011524439.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1107bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	N-acetylglutamate synthase, mitochondrial isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011524439.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGACATGA AGCCGCTGGT GGTCCTGGGG CTGCCGGCCC CTACGGCTCC CTCGGGCTGT 
CTTTCCTTCT GGGAGGCCAA GGCGCAGCTG GCCAAGAGCT GCAAGGTGCT GGTAGACGCG 
CTTCGACACA ACGCCGCCGC TGCTGTGCCA TTTTTTGGCG GCGGGTCTGT GCTACGCGCT 
GCCGAGCCGG CTCCCCATGC CAGCTACGGC GGCATCGTCT CGGTGGAGAC AGACCTGCTG 
CAGTGGTGCC TGGAGTCGGG CAGCATCCCC ATCCTGTGCC CCATCGGGGA GACGGCCGCG 
CGCCGCTCCG TGCTTCTCGA CTCCCTGGAG GTGACCGCGT CGCTGGCCAA GGCGCTGCGG 
CCCACCAAAA TCATCTTCCT CAATAACACA GGCGGCCTGC GCGACAGCAG TCATAAGGTC 
CTGAGTAACG TGAACCTGCC CGCCGACCTG GACCTGGTGT GCAACGCCGA GTGGGTGAGC 
ACAAAAGAAC GGCAGCAGAT GCGGCTCATC GTGGACGTGC TCAGCCGCCT GCCCCACCAC 
TCCTCGGCCG TCATCACCGC CGCTAGCACG CTGCTCACTG AGCTCTTTAG CAACAAGGGG 
TCCGGGACCC TGTTCAAGAA CGCCGAGCGA ATGCTACGGG TGCGCAGCCT GGACAAGCTG 
GACCAGGGCC GTCTAGTGGA CCTGGTCAAC GCCAGCTTCG GCAAGAAGCT CAGGGACGAC 
TACCTGGCCT CGCTGCGCCC GCGGCTGCAC TCCATCTACG TCTCCGAGGG GTACAACGCC 
GCCGCCATTC TGACCATGGA GCCCGTCCTG GGGGGCACCC CGTACCTGGA CAAATTTGTG 
GTGAGCTCCA GCCGCCAGGG CCAAGGCTCC GGCCAGATGC TGTGGGAGTG CCTGCGGCGG 
GACCTTCAGA CACTTTTCTG GCGCTCCCGG GTCACCAACC CCATCAATCC CTGGTACTTC 
AAACACAGTG ATGGCAGCTT CTCCAACAAG CAGTGGATCT TCTTCTGGTT TGGCCTGGCT 
GATATCCGGG ACTCCTATGA GTTGGTCAAC CACGCCAAGG GACTGCCAGA CTCCTTTCAC 
AAGCCAGCTT CTGACCCAGG CAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011522741.1
CDS	389..1495
Translation	MDMKPLVVLGLPAPTAPSGCLSFWEAKAQLAKSCKVLVDALRHNAAAAVPFFGGGSVLRAAEPAPHASYGGIVSVETDLLQWCLESGSIPILCPIGETAARRSVLLDSLEVTASLAKALRPTKIIFLNNTGGLRDSSHKVLSNVNLPADLDLVCNAEWVSTKERQQMRLIVDVLSRLPHHSSAVITAASTLLTELFSNKGSGTLFKNAERMLRVRSLDKLDQGRLVDLVNASFGKKLRDDYLASLRPRLHSIYVSEGYNAAAILTMEPVLGGTPYLDKFVVSSSRQGQGSGQMLWECLRRDLQTLFWRSRVTNPINPWYFKHSDGSFSNKQWIFFWFGLADIRDSYELVNHAKGLPDSFHKPASDPGS

Target ORF information:

RefSeq Version	XM_011524439.2
Organism	Homo sapiens(human)
Definition	Homo sapiens N-acetylglutamate synthase (NAGS), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011524439.2

ORF Insert Sequence:

ATGGACATGA AGCCGCTGGT GGTCCTGGGG CTGCCGGCCC CTACGGCTCC CTCGGGCTGT 
CTTTCCTTCT GGGAGGCCAA GGCGCAGCTG GCCAAGAGCT GCAAGGTGCT GGTAGACGCG 
CTTCGACACA ACGCCGCCGC TGCTGTGCCA TTTTTTGGCG GCGGGTCTGT GCTACGCGCT 
GCCGAGCCGG CTCCCCATGC CAGCTACGGC GGCATCGTCT CGGTGGAGAC AGACCTGCTG 
CAGTGGTGCC TGGAGTCGGG CAGCATCCCC ATCCTGTGCC CCATCGGGGA GACGGCCGCG 
CGCCGCTCCG TGCTTCTCGA CTCCCTGGAG GTGACCGCGT CGCTGGCCAA GGCGCTGCGG 
CCCACCAAAA TCATCTTCCT CAATAACACA GGCGGCCTGC GCGACAGCAG TCATAAGGTC 
CTGAGTAACG TGAACCTGCC CGCCGACCTG GACCTGGTGT GCAACGCCGA GTGGGTGAGC 
ACAAAAGAAC GGCAGCAGAT GCGGCTCATC GTGGACGTGC TCAGCCGCCT GCCCCACCAC 
TCCTCGGCCG TCATCACCGC CGCTAGCACG CTGCTCACTG AGCTCTTTAG CAACAAGGGG 
TCCGGGACCC TGTTCAAGAA CGCCGAGCGA ATGCTACGGG TGCGCAGCCT GGACAAGCTG 
GACCAGGGCC GTCTAGTGGA CCTGGTCAAC GCCAGCTTCG GCAAGAAGCT CAGGGACGAC 
TACCTGGCCT CGCTGCGCCC GCGGCTGCAC TCCATCTACG TCTCCGAGGG GTACAACGCC 
GCCGCCATTC TGACCATGGA GCCCGTCCTG GGGGGCACCC CGTACCTGGA CAAATTTGTG 
GTGAGCTCCA GCCGCCAGGG CCAAGGCTCC GGCCAGATGC TGTGGGAGTG CCTGCGGCGG 
GACCTTCAGA CACTTTTCTG GCGCTCCCGG GTCACCAACC CCATCAATCC CTGGTACTTC 
AAACACAGTG ATGGCAGCTT CTCCAACAAG CAGTGGATCT TCTTCTGGTT TGGCCTGGCT 
GATATCCGGG ACTCCTATGA GTTGGTCAAC CACGCCAAGG GACTGCCAGA CTCCTTTCAC 
AAGCCAGCTT CTGACCCAGG CAGCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NAGS ( NM_153006.2 ) cDNA ORF clone, Homo sapiens(human) -> NP_694551.1 Homo sapiens N-acetylglutamate synthase (NAGS), mRNA.

Price & Availability↑

CloneID	OHu24956
Clone ID Related Accession (Same CDS sequence)	NM_153006.2 , NM_153006.3
Accession Version	NM_153006.2	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-02-16
Organism	Homo sapiens(human)
Product	N-acetylglutamate synthase, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AY116538.1, BF589712.1 and AI241153.1. This sequence is a reference standard in the RefSeqGene project. On May 19, 2005 this sequence version replaced NM_153006.1. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: AY116538.1, AK314432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGACGG CGCTGATGGC TGTGGTTCTG CGGGCAGCTG CTGTAGCCCC GAGGCTGAGA 
GGCCGGGGAG GCACTGGGGG CGCCCGAAGG CTGAGCTGTG GCGCGCGGCG GCGGGCGGCG 
AGGGGCACCA GCCCGGGGCG CCGGCTCAGC ACCGCCTGGT CGCAGCCCCA GCCCCCGCCC 
GAGGAGTACG CGGGCGCGGA CGACGTCTCC CAGTCGCCCG TCGCCGAGGA GCCGTCGTGG 
GTGCCGAGTC CCAGGCCCCC GGTGCCCCAC GAGTCCCCAG AGCCTCCTTC GGGCCGCTCG 
CTGGTGCAGC GGGACATCCA GGCCTTCCTG AACCAGTGCG GGGCCAGCCC TGGGGAGGCG 
CGCCACTGGC TCACGCAGTT CCAGACCTGC CATCACTCCG CGGACAAGCC CTTCGCCGTC 
ATCGAGGTGG ACGAGGAGGT GCTCAAGTGC CAGCAGGGCG TATCCAGTCT GGCCTTTGCC 
CTGGCCTTCT TGCAGCGCAT GGACATGAAG CCGCTGGTGG TCCTGGGGCT GCCGGCCCCT 
ACGGCTCCCT CGGGCTGTCT TTCCTTCTGG GAGGCCAAGG CGCAGCTGGC CAAGAGCTGC 
AAGGTGCTGG TAGACGCGCT TCGACACAAC GCCGCCGCTG CTGTGCCATT TTTTGGCGGC 
GGGTCTGTGC TACGCGCTGC CGAGCCGGCT CCCCATGCCA GCTACGGCGG CATCGTCTCG 
GTGGAGACAG ACCTGCTGCA GTGGTGCCTG GAGTCGGGCA GCATCCCCAT CCTGTGCCCC 
ATCGGGGAGA CGGCCGCGCG CCGCTCCGTG CTTCTCGACT CCCTGGAGGT GACCGCGTCG 
CTGGCCAAGG CGCTGCGGCC CACCAAAATC ATCTTCCTCA ATAACACAGG CGGCCTGCGC 
GACAGCAGTC ATAAGGTCCT GAGTAACGTG AACCTGCCCG CCGACCTGGA CCTGGTGTGC 
AACGCCGAGT GGGTGAGCAC AAAAGAACGG CAGCAGATGC GGCTCATCGT GGACGTGCTC 
AGCCGCCTGC CCCACCACTC CTCGGCCGTC ATCACCGCCG CTAGCACGCT GCTCACTGAG 
CTCTTTAGCA ACAAGGGGTC CGGGACCCTG TTCAAGAACG CCGAGCGAAT GCTACGGGTG 
CGCAGCCTGG ACAAGCTGGA CCAGGGCCGT CTAGTGGACC TGGTCAACGC CAGCTTCGGC 
AAGAAGCTCA GGGACGACTA CCTGGCCTCG CTGCGCCCGC GGCTGCACTC CATCTACGTC 
TCCGAGGGGT ACAACGCCGC CGCCATTCTG ACCATGGAGC CCGTCCTGGG GGGCACCCCG 
TACCTGGACA AATTTGTGGT GAGCTCCAGC CGCCAGGGCC AAGGCTCCGG CCAGATGCTG 
TGGGAGTGCC TGCGGCGGGA CCTTCAGACA CTTTTCTGGC GCTCCCGGGT CACCAACCCC 
ATCAATCCCT GGTACTTCAA ACACAGTGAT GGCAGCTTCT CCAACAAGCA GTGGATCTTC 
TTCTGGTTTG GCCTGGCTGA TATCCGGGAC TCCTATGAGT TGGTCAACCA CGCCAAGGGA 
CTGCCAGACT CCTTTCACAA GCCAGCTTCT GACCCAGGCA GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694551.1
CDS	1..1605
Translation	MATALMAVVLRAAAVAPRLRGRGGTGGARRLSCGARRRAARGTSPGRRLSTAWSQPQPPPEEYAGADDVSQSPVAEEPSWVPSPRPPVPHESPEPPSGRSLVQRDIQAFLNQCGASPGEARHWLTQFQTCHHSADKPFAVIEVDEEVLKCQQGVSSLAFALAFLQRMDMKPLVVLGLPAPTAPSGCLSFWEAKAQLAKSCKVLVDALRHNAAAAVPFFGGGSVLRAAEPAPHASYGGIVSVETDLLQWCLESGSIPILCPIGETAARRSVLLDSLEVTASLAKALRPTKIIFLNNTGGLRDSSHKVLSNVNLPADLDLVCNAEWVSTKERQQMRLIVDVLSRLPHHSSAVITAASTLLTELFSNKGSGTLFKNAERMLRVRSLDKLDQGRLVDLVNASFGKKLRDDYLASLRPRLHSIYVSEGYNAAAILTMEPVLGGTPYLDKFVVSSSRQGQGSGQMLWECLRRDLQTLFWRSRVTNPINPWYFKHSDGSFSNKQWIFFWFGLADIRDSYELVNHAKGLPDSFHKPASDPGS

Target ORF information:

RefSeq Version	NM_153006.2
Organism	Homo sapiens(human)
Definition	Homo sapiens N-acetylglutamate synthase (NAGS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153006.2

ORF Insert Sequence:

ATGGCGACGG CGCTGATGGC TGTGGTTCTG CGGGCAGCTG CTGTAGCCCC GAGGCTGAGA 
GGCCGGGGAG GCACTGGGGG CGCCCGAAGG CTGAGCTGTG GCGCGCGGCG GCGGGCGGCG 
AGGGGCACCA GCCCGGGGCG CCGGCTCAGC ACCGCCTGGT CGCAGCCCCA GCCCCCGCCC 
GAGGAGTACG CGGGCGCGGA CGACGTCTCC CAGTCGCCCG TCGCCGAGGA GCCGTCGTGG 
GTGCCGAGTC CCAGGCCCCC GGTGCCCCAC GAGTCCCCAG AGCCTCCTTC GGGCCGCTCG 
CTGGTGCAGC GGGACATCCA GGCCTTCCTG AACCAGTGCG GGGCCAGCCC TGGGGAGGCG 
CGCCACTGGC TCACGCAGTT CCAGACCTGC CATCACTCCG CGGACAAGCC CTTCGCCGTC 
ATCGAGGTGG ACGAGGAGGT GCTCAAGTGC CAGCAGGGCG TATCCAGTCT GGCCTTTGCC 
CTGGCCTTCT TGCAGCGCAT GGACATGAAG CCGCTGGTGG TCCTGGGGCT GCCGGCCCCT 
ACGGCTCCCT CGGGCTGTCT TTCCTTCTGG GAGGCCAAGG CGCAGCTGGC CAAGAGCTGC 
AAGGTGCTGG TAGACGCGCT TCGACACAAC GCCGCCGCTG CTGTGCCATT TTTTGGCGGC 
GGGTCTGTGC TACGCGCTGC CGAGCCGGCT CCCCATGCCA GCTACGGCGG CATCGTCTCG 
GTGGAGACAG ACCTGCTGCA GTGGTGCCTG GAGTCGGGCA GCATCCCCAT CCTGTGCCCC 
ATCGGGGAGA CGGCCGCGCG CCGCTCCGTG CTTCTCGACT CCCTGGAGGT GACCGCGTCG 
CTGGCCAAGG CGCTGCGGCC CACCAAAATC ATCTTCCTCA ATAACACAGG CGGCCTGCGC 
GACAGCAGTC ATAAGGTCCT GAGTAACGTG AACCTGCCCG CCGACCTGGA CCTGGTGTGC 
AACGCCGAGT GGGTGAGCAC AAAAGAACGG CAGCAGATGC GGCTCATCGT GGACGTGCTC 
AGCCGCCTGC CCCACCACTC CTCGGCCGTC ATCACCGCCG CTAGCACGCT GCTCACTGAG 
CTCTTTAGCA ACAAGGGGTC CGGGACCCTG TTCAAGAACG CCGAGCGAAT GCTACGGGTG 
CGCAGCCTGG ACAAGCTGGA CCAGGGCCGT CTAGTGGACC TGGTCAACGC CAGCTTCGGC 
AAGAAGCTCA GGGACGACTA CCTGGCCTCG CTGCGCCCGC GGCTGCACTC CATCTACGTC 
TCCGAGGGGT ACAACGCCGC CGCCATTCTG ACCATGGAGC CCGTCCTGGG GGGCACCCCG 
TACCTGGACA AATTTGTGGT GAGCTCCAGC CGCCAGGGCC AAGGCTCCGG CCAGATGCTG 
TGGGAGTGCC TGCGGCGGGA CCTTCAGACA CTTTTCTGGC GCTCCCGGGT CACCAACCCC 
ATCAATCCCT GGTACTTCAA ACACAGTGAT GGCAGCTTCT CCAACAAGCA GTGGATCTTC 
TTCTGGTTTG GCCTGGCTGA TATCCGGGAC TCCTATGAGT TGGTCAACCA CGCCAAGGGA 
CTGCCAGACT CCTTTCACAA GCCAGCTTCT GACCCAGGCA GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NAGS ( NM_153006.3 ) cDNA ORF clone, Homo sapiens(human) -> NP_694551.1 Homo sapiens N-acetylglutamate synthase (NAGS), mRNA.

Price & Availability↑

CloneID	OHu24956
Clone ID Related Accession (Same CDS sequence)	NM_153006.2 , NM_153006.3
Accession Version	NM_153006.3 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1605bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2020-01-01
Organism	Homo sapiens(human)
Product	N-acetylglutamate synthase, mitochondrial
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC023855.15, AY116538.1, BF589712.1 and AI241153.1. This sequence is a reference standard in the RefSeqGene project. On May 17, 2019 this sequence version replaced NM_153006.2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: SRR6380199.94103.17, AK314432.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMEA1968540, SAMEA1970526 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## gene product(s) localized to mito. :: reported by MitoCarta MANE Ensembl match :: ENST00000293404.8/ ENSP00000293404.2 RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGGCGACGG CGCTGATGGC TGTGGTTCTG CGGGCAGCTG CTGTAGCCCC GAGGCTGAGA 
GGCCGGGGAG GCACTGGGGG CGCCCGAAGG CTGAGCTGTG GCGCGCGGCG GCGGGCGGCG 
AGGGGCACCA GCCCGGGGCG CCGGCTCAGC ACCGCCTGGT CGCAGCCCCA GCCCCCGCCC 
GAGGAGTACG CGGGCGCGGA CGACGTCTCC CAGTCGCCCG TCGCCGAGGA GCCGTCGTGG 
GTGCCGAGTC CCAGGCCCCC GGTGCCCCAC GAGTCCCCAG AGCCTCCTTC GGGCCGCTCG 
CTGGTGCAGC GGGACATCCA GGCCTTCCTG AACCAGTGCG GGGCCAGCCC TGGGGAGGCG 
CGCCACTGGC TCACGCAGTT CCAGACCTGC CATCACTCCG CGGACAAGCC CTTCGCCGTC 
ATCGAGGTGG ACGAGGAGGT GCTCAAGTGC CAGCAGGGCG TATCCAGTCT GGCCTTTGCC 
CTGGCCTTCT TGCAGCGCAT GGACATGAAG CCGCTGGTGG TCCTGGGGCT GCCGGCCCCT 
ACGGCTCCCT CGGGCTGTCT TTCCTTCTGG GAGGCCAAGG CGCAGCTGGC CAAGAGCTGC 
AAGGTGCTGG TAGACGCGCT TCGACACAAC GCCGCCGCTG CTGTGCCATT TTTTGGCGGC 
GGGTCTGTGC TACGCGCTGC CGAGCCGGCT CCCCATGCCA GCTACGGCGG CATCGTCTCG 
GTGGAGACAG ACCTGCTGCA GTGGTGCCTG GAGTCGGGCA GCATCCCCAT CCTGTGCCCC 
ATCGGGGAGA CGGCCGCGCG CCGCTCCGTG CTTCTCGACT CCCTGGAGGT GACCGCGTCG 
CTGGCCAAGG CGCTGCGGCC CACCAAAATC ATCTTCCTCA ATAACACAGG CGGCCTGCGC 
GACAGCAGTC ATAAGGTCCT GAGTAACGTG AACCTGCCCG CCGACCTGGA CCTGGTGTGC 
AACGCCGAGT GGGTGAGCAC AAAAGAACGG CAGCAGATGC GGCTCATCGT GGACGTGCTC 
AGCCGCCTGC CCCACCACTC CTCGGCCGTC ATCACCGCCG CTAGCACGCT GCTCACTGAG 
CTCTTTAGCA ACAAGGGGTC CGGGACCCTG TTCAAGAACG CCGAGCGAAT GCTACGGGTG 
CGCAGCCTGG ACAAGCTGGA CCAGGGCCGT CTAGTGGACC TGGTCAACGC CAGCTTCGGC 
AAGAAGCTCA GGGACGACTA CCTGGCCTCG CTGCGCCCGC GGCTGCACTC CATCTACGTC 
TCCGAGGGGT ACAACGCCGC CGCCATTCTG ACCATGGAGC CCGTCCTGGG GGGCACCCCG 
TACCTGGACA AATTTGTGGT GAGCTCCAGC CGCCAGGGCC AAGGCTCCGG CCAGATGCTG 
TGGGAGTGCC TGCGGCGGGA CCTTCAGACA CTTTTCTGGC GCTCCCGGGT CACCAACCCC 
ATCAATCCCT GGTACTTCAA ACACAGTGAT GGCAGCTTCT CCAACAAGCA GTGGATCTTC 
TTCTGGTTTG GCCTGGCTGA TATCCGGGAC TCCTATGAGT TGGTCAACCA CGCCAAGGGA 
CTGCCAGACT CCTTTCACAA GCCAGCTTCT GACCCAGGCA GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_694551.1
CDS	43..1647
Translation	MATALMAVVLRAAAVAPRLRGRGGTGGARRLSCGARRRAARGTSPGRRLSTAWSQPQPPPEEYAGADDVSQSPVAEEPSWVPSPRPPVPHESPEPPSGRSLVQRDIQAFLNQCGASPGEARHWLTQFQTCHHSADKPFAVIEVDEEVLKCQQGVSSLAFALAFLQRMDMKPLVVLGLPAPTAPSGCLSFWEAKAQLAKSCKVLVDALRHNAAAAVPFFGGGSVLRAAEPAPHASYGGIVSVETDLLQWCLESGSIPILCPIGETAARRSVLLDSLEVTASLAKALRPTKIIFLNNTGGLRDSSHKVLSNVNLPADLDLVCNAEWVSTKERQQMRLIVDVLSRLPHHSSAVITAASTLLTELFSNKGSGTLFKNAERMLRVRSLDKLDQGRLVDLVNASFGKKLRDDYLASLRPRLHSIYVSEGYNAAAILTMEPVLGGTPYLDKFVVSSSRQGQGSGQMLWECLRRDLQTLFWRSRVTNPINPWYFKHSDGSFSNKQWIFFWFGLADIRDSYELVNHAKGLPDSFHKPASDPGS

Target ORF information:

RefSeq Version	NM_153006.3
Organism	Homo sapiens(human)
Definition	Homo sapiens N-acetylglutamate synthase (NAGS), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_153006.3

ORF Insert Sequence:

ATGGCGACGG CGCTGATGGC TGTGGTTCTG CGGGCAGCTG CTGTAGCCCC GAGGCTGAGA 
GGCCGGGGAG GCACTGGGGG CGCCCGAAGG CTGAGCTGTG GCGCGCGGCG GCGGGCGGCG 
AGGGGCACCA GCCCGGGGCG CCGGCTCAGC ACCGCCTGGT CGCAGCCCCA GCCCCCGCCC 
GAGGAGTACG CGGGCGCGGA CGACGTCTCC CAGTCGCCCG TCGCCGAGGA GCCGTCGTGG 
GTGCCGAGTC CCAGGCCCCC GGTGCCCCAC GAGTCCCCAG AGCCTCCTTC GGGCCGCTCG 
CTGGTGCAGC GGGACATCCA GGCCTTCCTG AACCAGTGCG GGGCCAGCCC TGGGGAGGCG 
CGCCACTGGC TCACGCAGTT CCAGACCTGC CATCACTCCG CGGACAAGCC CTTCGCCGTC 
ATCGAGGTGG ACGAGGAGGT GCTCAAGTGC CAGCAGGGCG TATCCAGTCT GGCCTTTGCC 
CTGGCCTTCT TGCAGCGCAT GGACATGAAG CCGCTGGTGG TCCTGGGGCT GCCGGCCCCT 
ACGGCTCCCT CGGGCTGTCT TTCCTTCTGG GAGGCCAAGG CGCAGCTGGC CAAGAGCTGC 
AAGGTGCTGG TAGACGCGCT TCGACACAAC GCCGCCGCTG CTGTGCCATT TTTTGGCGGC 
GGGTCTGTGC TACGCGCTGC CGAGCCGGCT CCCCATGCCA GCTACGGCGG CATCGTCTCG 
GTGGAGACAG ACCTGCTGCA GTGGTGCCTG GAGTCGGGCA GCATCCCCAT CCTGTGCCCC 
ATCGGGGAGA CGGCCGCGCG CCGCTCCGTG CTTCTCGACT CCCTGGAGGT GACCGCGTCG 
CTGGCCAAGG CGCTGCGGCC CACCAAAATC ATCTTCCTCA ATAACACAGG CGGCCTGCGC 
GACAGCAGTC ATAAGGTCCT GAGTAACGTG AACCTGCCCG CCGACCTGGA CCTGGTGTGC 
AACGCCGAGT GGGTGAGCAC AAAAGAACGG CAGCAGATGC GGCTCATCGT GGACGTGCTC 
AGCCGCCTGC CCCACCACTC CTCGGCCGTC ATCACCGCCG CTAGCACGCT GCTCACTGAG 
CTCTTTAGCA ACAAGGGGTC CGGGACCCTG TTCAAGAACG CCGAGCGAAT GCTACGGGTG 
CGCAGCCTGG ACAAGCTGGA CCAGGGCCGT CTAGTGGACC TGGTCAACGC CAGCTTCGGC 
AAGAAGCTCA GGGACGACTA CCTGGCCTCG CTGCGCCCGC GGCTGCACTC CATCTACGTC 
TCCGAGGGGT ACAACGCCGC CGCCATTCTG ACCATGGAGC CCGTCCTGGG GGGCACCCCG 
TACCTGGACA AATTTGTGGT GAGCTCCAGC CGCCAGGGCC AAGGCTCCGG CCAGATGCTG 
TGGGAGTGCC TGCGGCGGGA CCTTCAGACA CTTTTCTGGC GCTCCCGGGT CACCAACCCC 
ATCAATCCCT GGTACTTCAA ACACAGTGAT GGCAGCTTCT CCAACAAGCA GTGGATCTTC 
TTCTGGTTTG GCCTGGCTGA TATCCGGGAC TCCTATGAGT TGGTCAACCA CGCCAAGGGA 
CTGCCAGACT CCTTTCACAA GCCAGCTTCT GACCCAGGCA GCTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

NAGS ( XM_011524438.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011522740.1 Homo sapiens N-acetylglutamate synthase (NAGS), transcript variant X1, mRNA.

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CloneID	OHu77173
Clone ID Related Accession (Same CDS sequence)	XM_011524438.1
Accession Version	XM_011524438.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1422bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	N-acetylglutamate synthase, mitochondrial isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000017.11) annotated using gene prediction method: Gnomon, supported by EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGCGACGG CGCTGATGGC TGTGGTTCTG CGGGCAGCTG CTGTAGCCCC GAGGCTGAGA 
GGCCGGGGAG GCACTGGGGG CGCCCGAAGG CTGAGCTGTG GCGCGCGGCG GCGGGCGGCG 
AGGGGCACCA GCCCGGGGCG CCGGCTCAGC ACCGCCTGGT CGCAGCCCCA GCCCCCGCCC 
GAGGAGTACG CGGGCGCGGA CGACGTCTCC CAGTCGCCCG TCGCCGAGGA GCCGTCGTGG 
GTGCCGAGTC CCAGGCCCCC GGTGCCCCAC GAGTCCCCAG AGCCTCCTTC GGGCCGCTCG 
CTGGTGCAGC GGGACATCCA GGCCTTCCTG AACCAGTGCG GGGCCAGCCC TGGGGAGGCG 
CGCCACTGGC TCACGCAGTT CCAGACCTGC CATCACTCCG CGGACAAGCC CTTCGCCGTC 
ATCGAGGTGG ACGAGGAGGT GCTCAAGTGC CAGCAGGGCG TATCCAGTCT GGCCTTTGCC 
CTGGCCTTCT TGCAGCGCAT GGACATGAAG CCGCTGGTGG TCCTGGGGCT GCCGGCCCCT 
ACGGCTCCCT CGGGCTGTCT TTCCTTCTGG GAGGCCAAGG CGCAGCTGGC CAAGAGCTGC 
AAGGTGCTGG TAGACGCGCT TCGACACAAC GCCGCCGCTG CTGTGCCATT TTTTGGCGGC 
GGGTCTGTGC TACGCGCTGC CGAGCCGGCT CCCCATGCCA GCTACGGCGG CATCGTCTCG 
GTGGAGACAG ACCTGCTGCA GTGGTGCCTG GAGTCGGGCA GCATCCCCAT CCTGTGCCCC 
ATCGGGGAGA CGGCCGCGCG CCGCTCCGTG CTTCTCGACT CCCTGGAGGT GACCGCGTCG 
CTGGCCAAGG CGCTGCGGCC CACCAAAATC ATCTTCCTCA ATAACACAGG CGGCCTGCGC 
GACAGCAGTC ATAAGGTCCT GAGTAACGTG AACCTGCCCG CCGACCTGGA CCTGGTGTGC 
AACGCCGAGT GGGTGAGCAC AAAAGAACGG CAGCAGATGC GGCTCATCGT GGACGTGCTC 
AGCCGCCTGC CCCACCACTC CTCGGCCGTC ATCACCGCCG CTAGCACGCT GCTCACTGAG 
CTCTTTAGCA ACAAGGGGTC CGGGACCCTG TTCAAGAACG CCGAGCGAAT GCTACGGGTG 
CGCAGCCTGG ACAAGCTGGA CCAGGGCCGT CTAGTGGACC TGGTCAACGC CAGCTTCGGC 
AAGAAGCTCA GGGACGACTA CCTGGCCTCG CTGCGCCCGC GGCTGCACTC CATCTACGTC 
TCCGAGGGGT ACTTCAAACA CAGTGATGGC AGCTTCTCCA ACAAGCAGTG GATCTTCTTC 
TGGTTTGGCC TGGCTGATAT CCGGGACTCC TATGAGTTGG TCAACCACGC CAAGGGACTG 
CCAGACTCCT TTCACAAGCC AGCTTCTGAC CCAGGCAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011522740.1
CDS	119..1540
Translation	MATALMAVVLRAAAVAPRLRGRGGTGGARRLSCGARRRAARGTSPGRRLSTAWSQPQPPPEEYAGADDVSQSPVAEEPSWVPSPRPPVPHESPEPPSGRSLVQRDIQAFLNQCGASPGEARHWLTQFQTCHHSADKPFAVIEVDEEVLKCQQGVSSLAFALAFLQRMDMKPLVVLGLPAPTAPSGCLSFWEAKAQLAKSCKVLVDALRHNAAAAVPFFGGGSVLRAAEPAPHASYGGIVSVETDLLQWCLESGSIPILCPIGETAARRSVLLDSLEVTASLAKALRPTKIIFLNNTGGLRDSSHKVLSNVNLPADLDLVCNAEWVSTKERQQMRLIVDVLSRLPHHSSAVITAASTLLTELFSNKGSGTLFKNAERMLRVRSLDKLDQGRLVDLVNASFGKKLRDDYLASLRPRLHSIYVSEGYFKHSDGSFSNKQWIFFWFGLADIRDSYELVNHAKGLPDSFHKPASDPGS

Target ORF information:

RefSeq Version	XM_011524438.1
Organism	Homo sapiens(human)
Definition	Homo sapiens N-acetylglutamate synthase (NAGS), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011524438.1

ORF Insert Sequence:

ATGGCGACGG CGCTGATGGC TGTGGTTCTG CGGGCAGCTG CTGTAGCCCC GAGGCTGAGA 
GGCCGGGGAG GCACTGGGGG CGCCCGAAGG CTGAGCTGTG GCGCGCGGCG GCGGGCGGCG 
AGGGGCACCA GCCCGGGGCG CCGGCTCAGC ACCGCCTGGT CGCAGCCCCA GCCCCCGCCC 
GAGGAGTACG CGGGCGCGGA CGACGTCTCC CAGTCGCCCG TCGCCGAGGA GCCGTCGTGG 
GTGCCGAGTC CCAGGCCCCC GGTGCCCCAC GAGTCCCCAG AGCCTCCTTC GGGCCGCTCG 
CTGGTGCAGC GGGACATCCA GGCCTTCCTG AACCAGTGCG GGGCCAGCCC TGGGGAGGCG 
CGCCACTGGC TCACGCAGTT CCAGACCTGC CATCACTCCG CGGACAAGCC CTTCGCCGTC 
ATCGAGGTGG ACGAGGAGGT GCTCAAGTGC CAGCAGGGCG TATCCAGTCT GGCCTTTGCC 
CTGGCCTTCT TGCAGCGCAT GGACATGAAG CCGCTGGTGG TCCTGGGGCT GCCGGCCCCT 
ACGGCTCCCT CGGGCTGTCT TTCCTTCTGG GAGGCCAAGG CGCAGCTGGC CAAGAGCTGC 
AAGGTGCTGG TAGACGCGCT TCGACACAAC GCCGCCGCTG CTGTGCCATT TTTTGGCGGC 
GGGTCTGTGC TACGCGCTGC CGAGCCGGCT CCCCATGCCA GCTACGGCGG CATCGTCTCG 
GTGGAGACAG ACCTGCTGCA GTGGTGCCTG GAGTCGGGCA GCATCCCCAT CCTGTGCCCC 
ATCGGGGAGA CGGCCGCGCG CCGCTCCGTG CTTCTCGACT CCCTGGAGGT GACCGCGTCG 
CTGGCCAAGG CGCTGCGGCC CACCAAAATC ATCTTCCTCA ATAACACAGG CGGCCTGCGC 
GACAGCAGTC ATAAGGTCCT GAGTAACGTG AACCTGCCCG CCGACCTGGA CCTGGTGTGC 
AACGCCGAGT GGGTGAGCAC AAAAGAACGG CAGCAGATGC GGCTCATCGT GGACGTGCTC 
AGCCGCCTGC CCCACCACTC CTCGGCCGTC ATCACCGCCG CTAGCACGCT GCTCACTGAG 
CTCTTTAGCA ACAAGGGGTC CGGGACCCTG TTCAAGAACG CCGAGCGAAT GCTACGGGTG 
CGCAGCCTGG ACAAGCTGGA CCAGGGCCGT CTAGTGGACC TGGTCAACGC CAGCTTCGGC 
AAGAAGCTCA GGGACGACTA CCTGGCCTCG CTGCGCCCGC GGCTGCACTC CATCTACGTC 
TCCGAGGGGT ACTTCAAACA CAGTGATGGC AGCTTCTCCA ACAAGCAGTG GATCTTCTTC 
TGGTTTGGCC TGGCTGATAT CCGGGACTCC TATGAGTTGG TCAACCACGC CAAGGGACTG 
CCAGACTCCT TTCACAAGCC AGCTTCTGAC CCAGGCAGCT GA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

A novel UPLC-MS/MS based method to determine the activity of N-acetylglutamate synthase in liver tissue.
Molecular genetics and metabolism119(4)307-310(2016 12)
Dercksen M,Duran M,IJlst L,Kulik W,Ruiter JP,van Cruchten A,Tuchman M,Wanders RJ

Understanding N-Acetyl-L-Glutamate Synthase Deficiency: Mutational Spectrum, Impact of Clinical Mutations on Enzyme Functionality, and Structural Considerations.
Human mutation37(7)679-94(2016 07)
Sancho-Vaello E,Marco-Mar?n C,Gougeard N,Fern?ndez-Murga L,R?fenacht V,Mustedanagic M,Rubio V,H?berle J

Inhibition of N-acetylglutamate synthase by various monocarboxylic and dicarboxylic short-chain coenzyme A esters and the production of alternative glutamate esters.
Biochimica et biophysica acta1842(12 Pt A)2510-6(2014 Dec)
Dercksen M,IJlst L,Duran M,Mienie LJ,van Cruchten A,van der Westhuizen FH,Wanders RJ

Crystal structure of the N-acetyltransferase domain of human N-acetyl-L-glutamate synthase in complex with N-acetyl-L-glutamate provides insights into its catalytic and regulatory mechanisms.
PloS one8(7)e70369(2013)
Zhao G,Jin Z,Allewell NM,Tuchman M,Shi D

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NAGS cDNA ORF clone, Homo sapiens(human)

Gene

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gRNAs

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Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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