DAZ1 cDNA ORF clone, Homo sapiens(human)

Gene
Clones
gRNAs

Summary

Gene Symbol	DAZ1
Entrez Gene ID	1617
Full Name	deleted in azoospermia 1
Synonyms	DAZ,SPGY
General protein information	Preferred Names deleted in azoospermia 1 Names deleted in azoospermia protein 1 testicular tissue protein Li 49
Gene Type	protein-coding
Organism	Homo sapiens(human)
Genome	Chromosome: Y Map Location: Yq11.223
Summary	This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts containing three copies of the RRM domain have been described; thus the RefSeq for this gene contains only two RRM domains. [provided by RefSeq, Jul 2008].
Disorder MIM:	400003
Disorder Html:	?Sertoli-cell-only syndrome (1)

mRNA and Protein(s)

mRNA	Protein	Name
XM_011531482.2	XP_011529784.1	deleted in azoospermia protein 1 isoform X1
XM_011531483.1	XP_011529785.1	deleted in azoospermia protein 1 isoform X2
NM_004081.5	NP_004072.3	deleted in azoospermia protein 1

Pathways from BioSystems

Homologies

Homo sapiens (human)	DAZ4	NP_001005375.1
Homo sapiens (human)	DAZ1	NP_004072.3
Pan troglodytes (chimpanzee)	DAZ1	XP_003319020.2

Gene Ontology
Bibliography

Related articles in PubMed

High frequency of de novo DAZ microdeletion in sperm nuclei of subfertile men: possible involvement of genome instability in idiopathic male infertility.
Mozdarani H, Ghoraeian P, Mozdarani S, Fallahi P, Mohseni-Meybodi A
Human fertility (Cambridge, England)1-9(2017 May)

Analysis of partial azoospermia factor c deletion and DAZ copy number in azoospermia and severe oligozoospermia.
Alimardanian L, Saliminejad K, Razi S, Ahani A
Andrologia48(9)890-894(2016 Nov)

Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.
Zhang Y, Li M, Xiao F, Teng R, Zhang C, Lan A, Gu K, Li J, Wang D, Li H, Jiang L, Zeng S, He M, Huang Y, Guo P, Zhang X, Yang X
Gene571(1)9-16(2015 Oct)

Isoform-Level Gene Expression Profiles of Human Y Chromosome Azoospermia Factor Genes and Their X Chromosome Paralogs in the Testicular Tissue of Non-Obstructive Azoospermia Patients.
Ahmadi Rastegar D, Sharifi Tabar M, Alikhani M, Parsamatin P, Sahraneshin Samani F, Sabbaghian M, Sadighi Gilani MA, Mohammad Ahadi A, Mohseni Meybodi A, Piryaei A, Ansari-Pour N, Gourabi H, Baharvand H, Salekdeh GH
Journal of proteome research14(9)3595-605(2015 Sep)

Susceptibility of gr/gr rearrangements to azoospermia or oligozoospermia is dependent on DAZ and CDY1 gene copy deletions.
Sen S, Ambulkar P, Hinduja I, Zaveri K, Gokral J, Pal A, Modi D
Journal of assisted reproduction and genetics32(9)1333-41(2015 Sep)

GeneRIFs: Gene References Into Functions What's a GeneRIF?

We investigated partial deletion of AZFc region and DAZ copy number in a population of ian infertile men and normozoospermic controls.
Title: Analysis of partial azoospermia factor c deletion and DAZ copy number in azoospermia and severe oligozoospermia.

Studies indicate that partial RNA-binding proteins DAZ1/2 deletion was associated wih male infertility, but partial RNA-binding proteins DAZ3/4 deletion was not associated with male infertility.
Title: Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.

Overexpression of DAZ1 is associated with breast tumors.
Title: Transcriptome analysis of the cancer/testis genes, DAZ1, AURKC, and TEX101, in breast tumors and six breast cancer cell lines.

Susceptibility of gr/gr rearrangements to azoospermia or oligozoospermia is dependent on DAZ and CDY1 gene copy deletions.
Title: Susceptibility of gr/gr rearrangements to azoospermia or oligozoospermia is dependent on DAZ and CDY1 gene copy deletions.

We did not found any statistically significant genetic association between DAZ alleles and idiopathic male infertility
Title: [The association between DAZ T > C polymorphism and idiopathic male infertility risk in north of ].

The following DAZ1 gene cDNA ORF clone sequences were retrieved from the NCBI Reference Sequence Database (RefSeq). These sequences represent the protein coding region of the DAZ1 cDNA ORF which is encoded by the open reading frame (ORF) sequence. ORF sequences can be delivered in our standard vector, pcDNA3.1⁺/C-(K)DYK or the vector of your choice as an expression/transfection-ready ORF clone. Not the clone you want? Click here to find your clone.

***CloneID	Accession No.	Definition	**Vector	*Turnaround time	Price (USD)
OHu18741	NM_004081.5 Latest version!	Homo sapiens deleted in azoospermia 1 (DAZ1), mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$524.30 $749.00
OHu57199	XM_011531482.2 Latest version!	Homo sapiens deleted in azoospermia 1 (DAZ1), transcript variant X1, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$391.30 $559.00
OHu57200	XM_011531483.1 Latest version!	Homo sapiens deleted in azoospermia 1 (DAZ1), transcript variant X2, mRNA.	pcDNA3.1-C-(k)DYK or customized vector	TBD	$307.30 $439.00

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** GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories. In addition, please pay attention to the signal peptide, propeptide and transit peptide in target ORF, which may affect the choice of vector (N/C terminal tag vector).

***One clone ID might be correlated to multiple accession numbers, which share the same CDS sequence.

Reference Sequences (Refseq)

DAZ1 ( NM_004081.5 ) cDNA ORF clone, Homo sapiens(human) -> NP_004072.3 Homo sapiens deleted in azoospermia 1 (DAZ1), mRNA.

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CloneID	OHu18741
Clone ID Related Accession (Same CDS sequence)	NM_004081.5
Accession Version	NM_004081.5 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2235bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-11-09
Organism	Homo sapiens(human)
Product	deleted in azoospermia protein 1
Comment	Comment: REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from DB461291.1, BC114927.1, AF271088.1 and AC010088.4. This sequence is a reference standard in the RefSeqGene project. On May 30, 2008 this sequence version replaced NM_004081.4. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: HM005362.1 [ECO:0000332] RNAseq introns :: mixed/partial sample support SAMEA1968968, SAMEA2142586 [ECO:0000350] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on conservation, expression, longest protein ##RefSeq-Attributes-END## COMPLETENESS: complete on the 3' end.

ATGTCTGCTG CAAATCCTGA GACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCTTCATCAG CTGCAGCTAG CCAAGGCTGG GTGTTACCAG AAGGCAAAAT CGTGCCAAAC 
ACTGTTTTTG TTGGTGGAAT TGATGCTAGG ATGGATGAAA CTGAGATTGG AAGCTGCTTT 
GGTAGATACG GTTCAGTGAA AGAAGTGAAG ATAATCACGA ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCGTT TGTTAATGAC GTGGATGTCC AGAAGATAGT AGGATCACAG 
ATACATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAAGTTATGT 
GCTCGTCATG TGCAGCCACG TCCTTTGGTA GTTAATCCTC CTCCTCCACC ACAGTTTCAG 
AACGTCTGGC GGAATCCAAA CACTGAAACC TACCTGCAGC CCCAAATCAC GCCGAATCCT 
GTAACTCAGC ACGTTCAGTC TGCTGCAAAT CCTGAGACTC CAAACTCAAC CATCTCCAGA 
GAGGCCAGCA CCCAGTCTTC ATCAGCTGCA GCTAGCCAAG GCTGGGTGTT ACCAGAAGGC 
AAAATCGTGC CAAACACTGT TTTTGTTGGT GGAATTGATG CTAGGATGGA TGAAACTGAG 
ATTGGAAGCT GCTTTGGTAG ATACGGTTCA GTGAAAGAAG TGAAGATAAT CACGAATCGA 
ACTGGTGTGT CCAAAGGCTA TGGATTTGTT TCGTTTGTTA ATGACGTGGA TGTCCAGAAG 
ATAGTAGGAT CACAGATACA TTTCCATGGT AAAAAGCTGA AGCTGGGCCC TGCAATCAGG 
AAACAAAAGT TATGTGCTCG TCATGTGCAG CCACGTCCTT TGGTAGTTAA TCCTCCTCCT 
CCACCACAGT TTCAGAACGT CTGGCGGAAT CCAAACACTG AAACCTACCT GCAGCCCCAA 
ATCACGCCGA ATCCTGTAAC TCAGCACGTT CAGTCTGCTG CAAATCCTGA GACTCCAAAC 
TCAACCATCT CCAGAGAGGC CAGCACCCAG TCTTCATCAG CTGCAGCTAG CCAAGGCTGG 
GTGTTACCAG AAGGCAAAAT CGTGCCAAAC ACTGTTTTTG TTGGTGGAAT TGATGCTAGG 
ATGGATGAAA CTGAGATTGG AAGCTGCTTT GGTAGATACG GTTCAGTGAA AGAAGTGAAG 
ATAATCACGA ATCGAACTGG TGTGTCCAAA GGCTATGGAT TTGTTTCGTT TGTTAATGAC 
GTGGATGTCC AGAAGATAGT AGGATCACAG ATACATTTCC ATGGTAAAAA GCTGAAGCTG 
GGCCCTGCAA TCAGGAAACA AAAGTTATGT GCTCGTCATG TGCAGCCACG TCCTTTGGTA 
GTTAATCCTC CTCCTCCACC ACAGTTTCAG AACGTCTGGC GGAATCCAAA CACTGAAACC 
TACCTGCAGC CCCAAATCAC GCCGAATCCT GTAACTCAGC ACGTTCAGGC TTACTCTGCT 
TATCCACATT CACCAGGTCA GGTCATCACT GGATGTCAGT TGCTTGTATA TAATTATCAG 
GAATATCCTA CTTATCCCGA TTCAGCATTT CAGGTCACCA CTGGATATCA GTTGCCTGTA 
TATAATTATC AGCCATTTCC TGCTTATCCA AGATCACCAT TTCAGGTCAC TGCTGGATAT 
CAGTTGCCTG TATATAATTA TCAGGCATTT CCTGCTTATC CAAATTCACC ATTTCAAGTC 
GCCACTGGAT ATCAGTTCCC TGTATACAAT TATCAGCCAT TTCCTGCTTA TCCAAGTTCA 
CCATTTCAGG TCACTGCTGG ATATCAGTTG CCTGTATATA ATTATCAGGC ATTTCCTGCT 
TATCCAAATT CACCATTTCA AGTCGCCACT GGATATCAGT TCCCTGTATA CAATTATCAG 
GCATTTCCTG CTTATCCAAA TTCACCAGTT CAGGTCACCA CTGGATATCA GTTGCCTGTA 
TACAATTATC AGGCATTTCC TGCTTATCCA AGTTCACCAT TTCAGGTCAC CACTGGATAT 
CAGTTGCCTG TATATAATTA TCAGGCATTT CCTGCTTATC CAAATTCAGC AGTTCAGGTC 
ACCACTGGAT ATCAGTTCCA TGTATACAAT TACCAGATGC CACCGCAGTG CCCTGTTGGG 
GAGCAAAGGA GAAATCTGTG GACCGAAGCA TACAAATGGT GGTATCTTGT CTGTTTAATC 
CAGAGAAGAG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	NP_004072.3
CDS	293..2527
Translation	MSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQPFPAYPSSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQAFPAYPNSPVQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPNSAVQVTTGYQFHVYNYQMPPQCPVGEQRRNLWTEAYKWWYLVCLIQRRD

Target ORF information:

RefSeq Version	NM_004081.5
Organism	Homo sapiens(human)
Definition	Homo sapiens deleted in azoospermia 1 (DAZ1), mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

NM_004081.5

ORF Insert Sequence:

ATGTCTGCTG CAAATCCTGA GACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCTTCATCAG CTGCAGCTAG CCAAGGCTGG GTGTTACCAG AAGGCAAAAT CGTGCCAAAC 
ACTGTTTTTG TTGGTGGAAT TGATGCTAGG ATGGATGAAA CTGAGATTGG AAGCTGCTTT 
GGTAGATACG GTTCAGTGAA AGAAGTGAAG ATAATCACGA ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCGTT TGTTAATGAC GTGGATGTCC AGAAGATAGT AGGATCACAG 
ATACATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAAGTTATGT 
GCTCGTCATG TGCAGCCACG TCCTTTGGTA GTTAATCCTC CTCCTCCACC ACAGTTTCAG 
AACGTCTGGC GGAATCCAAA CACTGAAACC TACCTGCAGC CCCAAATCAC GCCGAATCCT 
GTAACTCAGC ACGTTCAGTC TGCTGCAAAT CCTGAGACTC CAAACTCAAC CATCTCCAGA 
GAGGCCAGCA CCCAGTCTTC ATCAGCTGCA GCTAGCCAAG GCTGGGTGTT ACCAGAAGGC 
AAAATCGTGC CAAACACTGT TTTTGTTGGT GGAATTGATG CTAGGATGGA TGAAACTGAG 
ATTGGAAGCT GCTTTGGTAG ATACGGTTCA GTGAAAGAAG TGAAGATAAT CACGAATCGA 
ACTGGTGTGT CCAAAGGCTA TGGATTTGTT TCGTTTGTTA ATGACGTGGA TGTCCAGAAG 
ATAGTAGGAT CACAGATACA TTTCCATGGT AAAAAGCTGA AGCTGGGCCC TGCAATCAGG 
AAACAAAAGT TATGTGCTCG TCATGTGCAG CCACGTCCTT TGGTAGTTAA TCCTCCTCCT 
CCACCACAGT TTCAGAACGT CTGGCGGAAT CCAAACACTG AAACCTACCT GCAGCCCCAA 
ATCACGCCGA ATCCTGTAAC TCAGCACGTT CAGTCTGCTG CAAATCCTGA GACTCCAAAC 
TCAACCATCT CCAGAGAGGC CAGCACCCAG TCTTCATCAG CTGCAGCTAG CCAAGGCTGG 
GTGTTACCAG AAGGCAAAAT CGTGCCAAAC ACTGTTTTTG TTGGTGGAAT TGATGCTAGG 
ATGGATGAAA CTGAGATTGG AAGCTGCTTT GGTAGATACG GTTCAGTGAA AGAAGTGAAG 
ATAATCACGA ATCGAACTGG TGTGTCCAAA GGCTATGGAT TTGTTTCGTT TGTTAATGAC 
GTGGATGTCC AGAAGATAGT AGGATCACAG ATACATTTCC ATGGTAAAAA GCTGAAGCTG 
GGCCCTGCAA TCAGGAAACA AAAGTTATGT GCTCGTCATG TGCAGCCACG TCCTTTGGTA 
GTTAATCCTC CTCCTCCACC ACAGTTTCAG AACGTCTGGC GGAATCCAAA CACTGAAACC 
TACCTGCAGC CCCAAATCAC GCCGAATCCT GTAACTCAGC ACGTTCAGGC TTACTCTGCT 
TATCCACATT CACCAGGTCA GGTCATCACT GGATGTCAGT TGCTTGTATA TAATTATCAG 
GAATATCCTA CTTATCCCGA TTCAGCATTT CAGGTCACCA CTGGATATCA GTTGCCTGTA 
TATAATTATC AGCCATTTCC TGCTTATCCA AGATCACCAT TTCAGGTCAC TGCTGGATAT 
CAGTTGCCTG TATATAATTA TCAGGCATTT CCTGCTTATC CAAATTCACC ATTTCAAGTC 
GCCACTGGAT ATCAGTTCCC TGTATACAAT TATCAGCCAT TTCCTGCTTA TCCAAGTTCA 
CCATTTCAGG TCACTGCTGG ATATCAGTTG CCTGTATATA ATTATCAGGC ATTTCCTGCT 
TATCCAAATT CACCATTTCA AGTCGCCACT GGATATCAGT TCCCTGTATA CAATTATCAG 
GCATTTCCTG CTTATCCAAA TTCACCAGTT CAGGTCACCA CTGGATATCA GTTGCCTGTA 
TACAATTATC AGGCATTTCC TGCTTATCCA AGTTCACCAT TTCAGGTCAC CACTGGATAT 
CAGTTGCCTG TATATAATTA TCAGGCATTT CCTGCTTATC CAAATTCAGC AGTTCAGGTC 
ACCACTGGAT ATCAGTTCCA TGTATACAAT TACCAGATGC CACCGCAGTG CCCTGTTGGG 
GAGCAAAGGA GAAATCTGTG GACCGAAGCA TACAAATGGT GGTATCTTGT CTGTTTAATC 
CAGAGAAGAG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DAZ1 ( XM_011531482.2 ) cDNA ORF clone, Homo sapiens(human) -> XP_011529784.1 Homo sapiens deleted in azoospermia 1 (DAZ1), transcript variant X1, mRNA.

Price & Availability↑

CloneID	OHu57199
Clone ID Related Accession (Same CDS sequence)	XM_011531482.2
Accession Version	XM_011531482.2 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 2085bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	deleted in azoospermia protein 1 isoform X1
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000024.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process On Jun 6, 2016 this sequence version replaced XM_011531482.1. ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGAAA CTGAGATTGG AAGCTGCTTT GGTAGATACG GTTCAGTGAA AGAAGTGAAG 
ATAATCACGA ATCGAACTGG TGTGTCCAAA GGCTATGGAT TTGTTTCGTT TGTTAATGAC 
GTGGATGTCC AGAAGATAGT AGGATCACAG ATACATTTCC ATGGTAAAAA GCTGAAGCTG 
GGCCCTGCAA TCAGGAAACA AAAGTTATGT GCTCGTCATG TGCAGCCACG TCCTTTGGTA 
GTTAATCCTC CTCCTCCACC ACAGTTTCAG AACGTCTGGC GGAATCCAAA CACTGAAACC 
TACCTGCAGC CCCAAATCAC GCCGAATCCT GTAACTCAGC ACGTTCAGTC TGCTGCAAAT 
CCTGAGACTC CAAACTCAAC CATCTCCAGA GAGGCCAGCA CCCAGTCTTC ATCAGCTGCA 
GCTAGCCAAG GCTGGGTGTT ACCAGAAGGC AAAATCGTGC CAAACACTGT TTTTGTTGGT 
GGAATTGATG CTAGGATGGA TGAAACTGAG ATTGGAAGCT GCTTTGGTAG ATACGGTTCA 
GTGAAAGAAG TGAAGATAAT CACGAATCGA ACTGGTGTGT CCAAAGGCTA TGGATTTGTT 
TCGTTTGTTA ATGACGTGGA TGTCCAGAAG ATAGTAGGAT CACAGATACA TTTCCATGGT 
AAAAAGCTGA AGCTGGGCCC TGCAATCAGG AAACAAAAGT TATGTGCTCG TCATGTGCAG 
CCACGTCCTT TGGTAGTTAA TCCTCCTCCT CCACCACAGT TTCAGAACGT CTGGCGGAAT 
CCAAACACTG AAACCTACCT GCAGCCCCAA ATCACGCCGA ATCCTGTAAC TCAGCACGTT 
CAGTCTGCTG CAAATCCTGA GACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCTTCATCAG CTGCAGCTAG CCAAGGCTGG GTGTTACCAG AAGGCAAAAT CGTGCCAAAC 
ACTGTTTTTG TTGGTGGAAT TGATGCTAGG ATGGATGAAA CTGAGATTGG AAGCTGCTTT 
GGTAGATACG GTTCAGTGAA AGAAGTGAAG ATAATCACGA ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCGTT TGTTAATGAC GTGGATGTCC AGAAGATAGT AGGATCACAG 
ATACATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAAGTTATGT 
GCTCGTCATG TGCAGCCACG TCCTTTGGTA GTTAATCCTC CTCCTCCACC ACAGTTTCAG 
AACGTCTGGC GGAATCCAAA CACTGAAACC TACCTGCAGC CCCAAATCAC GCCGAATCCT 
GTAACTCAGC ACGTTCAGGC TTACTCTGCT TATCCACATT CACCAGGTCA GGTCATCACT 
GGATGTCAGT TGCTTGTATA TAATTATCAG GAATATCCTA CTTATCCCGA TTCAGCATTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TATAATTATC AGCCATTTCC TGCTTATCCA 
AGATCACCAT TTCAGGTCAC TGCTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAATTCACC ATTTCAAGTC GCCACTGGAT ATCAGTTCCC TGTATACAAT 
TATCAGCCAT TTCCTGCTTA TCCAAGTTCA CCATTTCAGG TCACTGCTGG ATATCAGTTG 
CCTGTATATA ATTATCAGGC ATTTCCTGCT TATCCAAATT CACCATTTCA AGTCGCCACT 
GGATATCAGT TCCCTGTATA CAATTATCAG GCATTTCCTG CTTATCCAAA TTCACCAGTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TACAATTATC AGGCATTTCC TGCTTATCCA 
AGTTCACCAT TTCAGGTCAC CACTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAATTCAGC AGTTCAGGTC ACCACTGGAT ATCAGTTCCA TGTATACAAT 
TACCAGATGC CACCGCAGTG CCCTGTTGGG GAGCAAAGGA GAAATCTGTG GACCGAAGCA 
TACAAATGGT GGTATCTTGT CTGTTTAATC CAGAGAAGAG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011529784.1
CDS	481..2565
Translation	MDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQPFPAYPSSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQAFPAYPNSPVQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPNSAVQVTTGYQFHVYNYQMPPQCPVGEQRRNLWTEAYKWWYLVCLIQRRD

Target ORF information:

RefSeq Version	XM_011531482.2
Organism	Homo sapiens(human)
Definition	Homo sapiens deleted in azoospermia 1 (DAZ1), transcript variant X1, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011531482.2

ORF Insert Sequence:

ATGGATGAAA CTGAGATTGG AAGCTGCTTT GGTAGATACG GTTCAGTGAA AGAAGTGAAG 
ATAATCACGA ATCGAACTGG TGTGTCCAAA GGCTATGGAT TTGTTTCGTT TGTTAATGAC 
GTGGATGTCC AGAAGATAGT AGGATCACAG ATACATTTCC ATGGTAAAAA GCTGAAGCTG 
GGCCCTGCAA TCAGGAAACA AAAGTTATGT GCTCGTCATG TGCAGCCACG TCCTTTGGTA 
GTTAATCCTC CTCCTCCACC ACAGTTTCAG AACGTCTGGC GGAATCCAAA CACTGAAACC 
TACCTGCAGC CCCAAATCAC GCCGAATCCT GTAACTCAGC ACGTTCAGTC TGCTGCAAAT 
CCTGAGACTC CAAACTCAAC CATCTCCAGA GAGGCCAGCA CCCAGTCTTC ATCAGCTGCA 
GCTAGCCAAG GCTGGGTGTT ACCAGAAGGC AAAATCGTGC CAAACACTGT TTTTGTTGGT 
GGAATTGATG CTAGGATGGA TGAAACTGAG ATTGGAAGCT GCTTTGGTAG ATACGGTTCA 
GTGAAAGAAG TGAAGATAAT CACGAATCGA ACTGGTGTGT CCAAAGGCTA TGGATTTGTT 
TCGTTTGTTA ATGACGTGGA TGTCCAGAAG ATAGTAGGAT CACAGATACA TTTCCATGGT 
AAAAAGCTGA AGCTGGGCCC TGCAATCAGG AAACAAAAGT TATGTGCTCG TCATGTGCAG 
CCACGTCCTT TGGTAGTTAA TCCTCCTCCT CCACCACAGT TTCAGAACGT CTGGCGGAAT 
CCAAACACTG AAACCTACCT GCAGCCCCAA ATCACGCCGA ATCCTGTAAC TCAGCACGTT 
CAGTCTGCTG CAAATCCTGA GACTCCAAAC TCAACCATCT CCAGAGAGGC CAGCACCCAG 
TCTTCATCAG CTGCAGCTAG CCAAGGCTGG GTGTTACCAG AAGGCAAAAT CGTGCCAAAC 
ACTGTTTTTG TTGGTGGAAT TGATGCTAGG ATGGATGAAA CTGAGATTGG AAGCTGCTTT 
GGTAGATACG GTTCAGTGAA AGAAGTGAAG ATAATCACGA ATCGAACTGG TGTGTCCAAA 
GGCTATGGAT TTGTTTCGTT TGTTAATGAC GTGGATGTCC AGAAGATAGT AGGATCACAG 
ATACATTTCC ATGGTAAAAA GCTGAAGCTG GGCCCTGCAA TCAGGAAACA AAAGTTATGT 
GCTCGTCATG TGCAGCCACG TCCTTTGGTA GTTAATCCTC CTCCTCCACC ACAGTTTCAG 
AACGTCTGGC GGAATCCAAA CACTGAAACC TACCTGCAGC CCCAAATCAC GCCGAATCCT 
GTAACTCAGC ACGTTCAGGC TTACTCTGCT TATCCACATT CACCAGGTCA GGTCATCACT 
GGATGTCAGT TGCTTGTATA TAATTATCAG GAATATCCTA CTTATCCCGA TTCAGCATTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TATAATTATC AGCCATTTCC TGCTTATCCA 
AGATCACCAT TTCAGGTCAC TGCTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAATTCACC ATTTCAAGTC GCCACTGGAT ATCAGTTCCC TGTATACAAT 
TATCAGCCAT TTCCTGCTTA TCCAAGTTCA CCATTTCAGG TCACTGCTGG ATATCAGTTG 
CCTGTATATA ATTATCAGGC ATTTCCTGCT TATCCAAATT CACCATTTCA AGTCGCCACT 
GGATATCAGT TCCCTGTATA CAATTATCAG GCATTTCCTG CTTATCCAAA TTCACCAGTT 
CAGGTCACCA CTGGATATCA GTTGCCTGTA TACAATTATC AGGCATTTCC TGCTTATCCA 
AGTTCACCAT TTCAGGTCAC CACTGGATAT CAGTTGCCTG TATATAATTA TCAGGCATTT 
CCTGCTTATC CAAATTCAGC AGTTCAGGTC ACCACTGGAT ATCAGTTCCA TGTATACAAT 
TACCAGATGC CACCGCAGTG CCCTGTTGGG GAGCAAAGGA GAAATCTGTG GACCGAAGCA 
TACAAATGGT GGTATCTTGT CTGTTTAATC CAGAGAAGAG ACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

DAZ1 ( XM_011531483.1 ) cDNA ORF clone, Homo sapiens(human) -> XP_011529785.1 Homo sapiens deleted in azoospermia 1 (DAZ1), transcript variant X2, mRNA.

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CloneID	OHu57200
Clone ID Related Accession (Same CDS sequence)	XM_011531483.1
Accession Version	XM_011531483.1 Latest version!	Documents for ORF clone product in default vector
Sequence Information	ORF Nucleotide Sequence (Length: 1590bp) Protein sequence SNP
Vector	pcDNA3.1-C-(k)DYK or customized vector	User Manual
Clone information	Clone Map	MSDS
Tag on pcDNA3.1⁺/C-(K)DYK	C terminal DYKDDDDK tags
ORF Insert Method	CloneEZ™ Seamless cloning technology
Insert Structure	linear
Update Date	2019-12-05
Organism	Homo sapiens(human)
Product	deleted in azoospermia protein 1 isoform X2
Comment	Comment: MODEL REFSEQ: This record is predicted by automated computational analysis. This record is derived from a genomic sequence (NC_000024.10) annotated using gene prediction method: Gnomon, supported by mRNA and EST evidence. Also see: Documentation of NCBI's Annotation Process ##Genome-Annotation-Data-START## Annotation Provider :: NCBI Annotation Status :: Updated annotation Annotation Name :: Homo sapiens Updated Annotation Release 109.20191205 Annotation Version :: 109.20191205 Annotation Pipeline :: NCBI eukaryotic genome annotation pipeline Annotation Software Version :: 8.3 Annotation Method :: Best-placed RefSeq; propagated RefSeq model Features Annotated :: Gene; mRNA; CDS; ncRNA ##Genome-Annotation-Data-END##

ATGGATGAAA CTGAGATTGG AAGCTGCTTT GGTAGATACG GTTCAGTGAA AGAAGTGAAG 
ATAATCACGA ATCGAACTGG TGTGTCCAAA GGCTATGGAT TTGTTTCGTT TGTTAATGAC 
GTGGATGTCC AGAAGATAGT AGGATCACAG ATACATTTCC ATGGTAAAAA GCTGAAGCTG 
GGCCCTGCAA TCAGGAAACA AAAGTTATGT GCTCGTCATG TGCAGCCACG TCCTTTGGTA 
GTTAATCCTC CTCCTCCACC ACAGTTTCAG AACGTCTGGC GGAATCCAAA CACTGAAACC 
TACCTGCAGC CCCAAATCAC GCCGAATCCT GTAACTCAGC ACGTTCAGTC TGCTGCAAAT 
CCTGAGACTC CAAACTCAAC CATCTCCAGA GAGGCCAGCA CCCAGTCTTC ATCAGCTGCA 
GCTAGCCAAG GCTGGGTGTT ACCAGAAGGC AAAATCGTGC CAAACACTGT TTTTGTTGGT 
GGAATTGATG CTAGGATGGA TGAAACTGAG ATTGGAAGCT GCTTTGGTAG ATACGGTTCA 
GTGAAAGAAG TGAAGATAAT CACGAATCGA ACTGGTGTGT CCAAAGGCTA TGGATTTGTT 
TCGTTTGTTA ATGACGTGGA TGTCCAGAAG ATAGTAGGAT CACAGATACA TTTCCATGGT 
AAAAAGCTGA AGCTGGGCCC TGCAATCAGG AAACAAAAGT TATGTGCTCG TCATGTGCAG 
CCACGTCCTT TGGTAGTTAA TCCTCCTCCT CCACCACAGT TTCAGAACGT CTGGCGGAAT 
CCAAACACTG AAACCTACCT GCAGCCCCAA ATCACGCCGA ATCCTGTAAC TCAGCACGTT 
CAGGCTTACT CTGCTTATCC ACATTCACCA GGTCAGGTCA TCACTGGATG TCAGTTGCTT 
GTATATAATT ATCAGGAATA TCCTACTTAT CCCGATTCAG CATTTCAGGT CACCACTGGA 
TATCAGTTGC CTGTATATAA TTATCAGCCA TTTCCTGCTT ATCCAAGATC ACCATTTCAG 
GTCACTGCTG GATATCAGTT GCCTGTATAT AATTATCAGG CATTTCCTGC TTATCCAAAT 
TCACCATTTC AAGTCGCCAC TGGATATCAG TTCCCTGTAT ACAATTATCA GCCATTTCCT 
GCTTATCCAA GTTCACCATT TCAGGTCACT GCTGGATATC AGTTGCCTGT ATATAATTAT 
CAGGCATTTC CTGCTTATCC AAATTCACCA TTTCAAGTCG CCACTGGATA TCAGTTCCCT 
GTATACAATT ATCAGGCATT TCCTGCTTAT CCAAATTCAC CAGTTCAGGT CACCACTGGA 
TATCAGTTGC CTGTATACAA TTATCAGGCA TTTCCTGCTT ATCCAAGTTC ACCATTTCAG 
GTCACCACTG GATATCAGTT GCCTGTATAT AATTATCAGG CATTTCCTGC TTATCCAAAT 
TCAGCAGTTC AGGTCACCAC TGGATATCAG TTCCATGTAT ACAATTACCA GATGCCACCG 
CAGTGCCCTG TTGGGGAGCA AAGGAGAAAT CTGTGGACCG AAGCATACAA ATGGTGGTAT 
CTTGTCTGTT TAATCCAGAG AAGAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

RefSeq	XP_011529785.1
CDS	103..1692
Translation	MDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQSAANPETPNSTISREASTQSSSAAASQGWVLPEGKIVPNTVFVGGIDARMDETEIGSCFGRYGSVKEVKIITNRTGVSKGYGFVSFVNDVDVQKIVGSQIHFHGKKLKLGPAIRKQKLCARHVQPRPLVVNPPPPPQFQNVWRNPNTETYLQPQITPNPVTQHVQAYSAYPHSPGQVITGCQLLVYNYQEYPTYPDSAFQVTTGYQLPVYNYQPFPAYPRSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQPFPAYPSSPFQVTAGYQLPVYNYQAFPAYPNSPFQVATGYQFPVYNYQAFPAYPNSPVQVTTGYQLPVYNYQAFPAYPSSPFQVTTGYQLPVYNYQAFPAYPNSAVQVTTGYQFHVYNYQMPPQCPVGEQRRNLWTEAYKWWYLVCLIQRRD

Target ORF information:

RefSeq Version	XM_011531483.1
Organism	Homo sapiens(human)
Definition	Homo sapiens deleted in azoospermia 1 (DAZ1), transcript variant X2, mRNA.

Target ORF information:

Epitope	DYKDDDDK
Bacterial selection	AMP^R
Mammalian selection	Neo^R
Vector	pcDNA3.1⁺/C-(K)DYK

XM_011531483.1

ORF Insert Sequence:

ATGGATGAAA CTGAGATTGG AAGCTGCTTT GGTAGATACG GTTCAGTGAA AGAAGTGAAG 
ATAATCACGA ATCGAACTGG TGTGTCCAAA GGCTATGGAT TTGTTTCGTT TGTTAATGAC 
GTGGATGTCC AGAAGATAGT AGGATCACAG ATACATTTCC ATGGTAAAAA GCTGAAGCTG 
GGCCCTGCAA TCAGGAAACA AAAGTTATGT GCTCGTCATG TGCAGCCACG TCCTTTGGTA 
GTTAATCCTC CTCCTCCACC ACAGTTTCAG AACGTCTGGC GGAATCCAAA CACTGAAACC 
TACCTGCAGC CCCAAATCAC GCCGAATCCT GTAACTCAGC ACGTTCAGTC TGCTGCAAAT 
CCTGAGACTC CAAACTCAAC CATCTCCAGA GAGGCCAGCA CCCAGTCTTC ATCAGCTGCA 
GCTAGCCAAG GCTGGGTGTT ACCAGAAGGC AAAATCGTGC CAAACACTGT TTTTGTTGGT 
GGAATTGATG CTAGGATGGA TGAAACTGAG ATTGGAAGCT GCTTTGGTAG ATACGGTTCA 
GTGAAAGAAG TGAAGATAAT CACGAATCGA ACTGGTGTGT CCAAAGGCTA TGGATTTGTT 
TCGTTTGTTA ATGACGTGGA TGTCCAGAAG ATAGTAGGAT CACAGATACA TTTCCATGGT 
AAAAAGCTGA AGCTGGGCCC TGCAATCAGG AAACAAAAGT TATGTGCTCG TCATGTGCAG 
CCACGTCCTT TGGTAGTTAA TCCTCCTCCT CCACCACAGT TTCAGAACGT CTGGCGGAAT 
CCAAACACTG AAACCTACCT GCAGCCCCAA ATCACGCCGA ATCCTGTAAC TCAGCACGTT 
CAGGCTTACT CTGCTTATCC ACATTCACCA GGTCAGGTCA TCACTGGATG TCAGTTGCTT 
GTATATAATT ATCAGGAATA TCCTACTTAT CCCGATTCAG CATTTCAGGT CACCACTGGA 
TATCAGTTGC CTGTATATAA TTATCAGCCA TTTCCTGCTT ATCCAAGATC ACCATTTCAG 
GTCACTGCTG GATATCAGTT GCCTGTATAT AATTATCAGG CATTTCCTGC TTATCCAAAT 
TCACCATTTC AAGTCGCCAC TGGATATCAG TTCCCTGTAT ACAATTATCA GCCATTTCCT 
GCTTATCCAA GTTCACCATT TCAGGTCACT GCTGGATATC AGTTGCCTGT ATATAATTAT 
CAGGCATTTC CTGCTTATCC AAATTCACCA TTTCAAGTCG CCACTGGATA TCAGTTCCCT 
GTATACAATT ATCAGGCATT TCCTGCTTAT CCAAATTCAC CAGTTCAGGT CACCACTGGA 
TATCAGTTGC CTGTATACAA TTATCAGGCA TTTCCTGCTT ATCCAAGTTC ACCATTTCAG 
GTCACCACTG GATATCAGTT GCCTGTATAT AATTATCAGG CATTTCCTGC TTATCCAAAT 
TCAGCAGTTC AGGTCACCAC TGGATATCAG TTCCATGTAT ACAATTACCA GATGCCACCG 
CAGTGCCCTG TTGGGGAGCA AAGGAGAAAT CTGTGGACCG AAGCATACAA ATGGTGGTAT 
CTTGTCTGTT TAATCCAGAG AAGAGACTGA

The stop codons will be deleted if pcDNA3.1⁺/C-(K)DYK vector is selected.

PubMed

High frequency of de novo DAZ microdeletion in sperm nuclei of subfertile men: possible involvement of genome instability in idiopathic male infertility.
Human fertility (Cambridge, England)1-9(2017 May)
Mozdarani H,Ghoraeian P,Mozdarani S,Fallahi P,Mohseni-Meybodi A

Analysis of partial azoospermia factor c deletion and DAZ copy number in azoospermia and severe oligozoospermia.
Andrologia48(9)890-894(2016 Nov)
Alimardanian L,Saliminejad K,Razi S,Ahani A

Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.
Gene571(1)9-16(2015 Oct)
Zhang Y,Li M,Xiao F,Teng R,Zhang C,Lan A,Gu K,Li J,Wang D,Li H,Jiang L,Zeng S,He M,Huang Y,Guo P,Zhang X,Yang X

Isoform-Level Gene Expression Profiles of Human Y Chromosome Azoospermia Factor Genes and Their X Chromosome Paralogs in the Testicular Tissue of Non-Obstructive Azoospermia Patients.
Journal of proteome research14(9)3595-605(2015 Sep)
Ahmadi Rastegar D,Sharifi Tabar M,Alikhani M,Parsamatin P,Sahraneshin Samani F,Sabbaghian M,Sadighi Gilani MA,Mohammad Ahadi A,Mohseni Meybodi A,Piryaei A,Ansari-Pour N,Gourabi H,Baharvand H,Salekdeh GH

Susceptibility of gr/gr rearrangements to azoospermia or oligozoospermia is dependent on DAZ and CDY1 gene copy deletions.
Journal of assisted reproduction and genetics32(9)1333-41(2015 Sep)
Sen S,Ambulkar P,Hinduja I,Zaveri K,Gokral J,Pal A,Modi D

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DAZ1 cDNA ORF clone, Homo sapiens(human)

Gene

Clones

gRNAs

Related articles in PubMed

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

Target ORF information:

Target ORF information:

ORF Insert Sequence:

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